keyword
MENU ▼
Read by QxMD icon Read
search

B cells

keyword
https://www.readbyqxmd.com/read/29783206/-experimental-evaluation-of-the-therapeutic-potential-of-liposome-mediated-apoe3-gene-transfection-for-cerebral-atherosclerosis
#1
Vadym V Biloshytskyi, Alisa V Pachevska, Alina V Biloshytska, Valerii M Istoshyn, Maryna V Biloshytska, Olha B Shevnia
OBJECTIVE: Introduction: In recent years, a stroke has been the cause of high lethality, long-term and sustained disability, the problem of which is still far from being resolved. The root cause of stroke is atherosclerosis. The aim: Study of neurotrophic and neuroprotective functions of apoE in rat brain tissue in experimental atherosclerosis. PATIENTS AND METHODS: Materials and methods: The study included 60 sexually mature rats. The model of experimental atherosclerosis was created by Anichkov method...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783204/chondron-curvature-mapping-in-growth-plate-cartilage-under-compressive-loading
#2
Bhavya B Vendra, Esra Roan, John L Williams
The physis, or growth plate, is a layer of cartilage responsible for long bone growth. It is organized into reserve, proliferative and hypertrophic zones. Unlike the reserve zone where chondrocytes are randomly arranged, either singly or in pairs, the proliferative and hypertrophic chondrocytes are arranged within tubular structures called chondrons. In previous studies, the strain patterns within the compressed growth plate have been reported to be nonuniform and inhomogeneous, with an apparent random pattern in compressive strains and a localized appearance of tensile strains...
May 18, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29783188/%C3%AE-pyrone-compounds-flavonoids-and-maltol-glucoside-derivatives-from-herniaria-glabra-l-collected-in-the-ternopil-region-of-the-ukraine
#3
Solomiia Kozachok, Łukasz Pecio, Joanna Kolodziejczyk-Czepas, Svitlana Marchyshyn, Pawel Nowak, Jarosław Mołdoch, Wiesław Oleszek
The phytochemical investigation of the whole plant extracts of Herniaria glabra L. (Caryophyllaceae) led to the identification and isolation of four known flavonoids, one known and three undescribed maltol derivatives, and benzyl β-gentiobioside. The structures were established by extensive 1D and 2D NMR spectroscopic analyses, as well as HRESIMS data. For the first time in Herniaria genus, as well as in Caryophylaceae family the presence of apiorutin {quercetin 3-O-[(D-apio-β-d-furanosyl-(1 → 2)-O-[-α-l-rhamnopyranosyl-(1 → 6)]-β-d-glucopyranoside]} and licoagroside B {maltol 3-O-[6-O-(3-hydroxy-3-methylglutaroyl)]-β-d-glucopyranoside} were revealed...
May 18, 2018: Phytochemistry
https://www.readbyqxmd.com/read/29783099/leveraging-the-cruzain-s3-subsite-to-increase-affinity-for-reversible-covalent-inhibitors
#4
Lorenzo Cianni, Geraldo Sartori, Fabiana Rosini, Daniela De Vita, Gabriel Pires, Bianca Rebelo Lopes, Andrei Leitão, Antonio C B Burtoloso, Carlos A Montanari
Cruzain is the major cysteine protease of Trypanosoma cruzi, the etiological agent of Chagas disease. Reversible covalent cruzain inhibitors can block the steps of cell differentiation in the parasite and kill the organism. To this end, the description of how inhibitors modified at the P2/P3 positions lead to analogs with greater cruzain affinity to the S2/S3 subsites is of fundamental importance. Albeit many efforts are being employed in the characterization of the interaction processes with S2 subsite, little is known about the cruzain S3 subsite...
April 26, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29783078/delayed-bipolar-and-ganglion-cells-neuroretinal-processing-in-regular-cannabis-users-the-retina-as-a-relevant-site-to-investigate-brain-synaptic-transmission-dysfunctions
#5
Thomas Schwitzer, Raymund Schwan, Karine Angioi-Duprez, Anne Giersch, Laurence Lalanne, Eliane Albuisson, Vincent Laprevote
Cannabis use is widespread worldwide, but the impact of smoking cannabis regularly on brain synaptic transmission has only been partially elucidated. The retina is considered as an easy means of determining dysfunction in brain synaptic transmission. The endocannabinoid system is involved in regulating retinal synaptic transmission, which might also be affected by tobacco. Previous preliminary results have shown impairments in retinal ganglion cell response in cannabis users. Here, we test the extent to which earlier retinal levels-bipolar cells and photoreceptors-are affected in cannabis users, i...
May 1, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29783056/treatment-of-winery-wastewater-by-anodic-oxidation-using-bdd-electrode
#6
Christian Candia-Onfray, Nicole Espinoza, Evanimek B Sabino da Silva, Carla Toledo-Neira, L Carolina Espinoza, Rocío Santander, Verónica García, Ricardo Salazar
The effective removal of organics from winery wastewater was obtained in real residual effluents from the wine industry using anodic oxidation (AO). The effluent had an initial organic load of [COD]0 of 3490 mg L-1 equal to [TOC]0 of 1320 mg L-1 . In addition, more than 40 organic compounds were identified by means of GC-MS. Different density currents as well as the addition of electrolytes were tested during electrolysis. The results show the decay of [COD]t by 63.6% when no support electrolyte was added, whereas almost total mineralization and disinfection was reached after adding of 50 mM of sodium sulfate and sodium chloride and applying higher density currents...
May 4, 2018: Chemosphere
https://www.readbyqxmd.com/read/29783053/biomineralization-mechanism-of-u-vi-induced-by-bacillus-cereus-12-2-the-role-of-functional-groups-and-enzymes
#7
Jian Zhang, Han Song, Zhi Chen, Shasha Liu, Yali Wei, Jingyi Huang, Chuling Guo, Zhi Dang, Zhang Lin
Current studies reveal that the biomineralization of U(VI) by anaerobes normally produces nano-sized U(IV) minerals that can easily re-migrate/re-oxidize, while the biomineralization of U(VI) by aerobes has been constrained because the general mechanism has not yet been fully characterized. The biomineralization of U(VI) by Bacillus cereus 12-2 was investigated in this work. The maximum biosorption capability of intact cells was 448.68 mg U/g biomass (dry weight) at pH 5, while a decrease over 60% was induced when phosphate, amino, and especially carboxyl groups were shielded...
May 10, 2018: Chemosphere
https://www.readbyqxmd.com/read/29783052/the-effect-of-the-supporting-electrolyte-on-the-electrooxidation-of-enrofloxacin-using-a-flow-cell-with-a-bdd-anode-kinetics-and-follow-up-of-oxidation-intermediates-and-antimicrobial-activity
#8
Jussara F Carneiro, José M Aquino, Adilson J Silva, Juliana C Barreiro, Quezia B Cass, Romeu C Rocha-Filho
The role of the supporting electrolyte - SE (Na2 SO4 ; NaCl; Na2 CO3 ; NaNO3 ; Na3 PO4 - 0.1 M ionic strength) in the galvanostatic (10 mA cm-2 ) electrochemical degradation of the fluoroquinolone antibiotic enrofloxacin (ENRO; 100 mg L-1 ) using a filter-press flow cell with a boron-doped diamond anode was investigated (flow rate, solution volume, and temperature were kept fixed at 420 L h-1 , 1.0 L, and 25 °C, respectively). The electrochemical degradation performance with the different SEs was assessed by following up [ENRO], total organic carbon concentration (TOC), oxidation intermediates (detected by LC and LC-QqTOF), and antimicrobial activity towards Escherichia coli as the electrolyses progressed...
May 10, 2018: Chemosphere
https://www.readbyqxmd.com/read/29782985/facile-preparation-of-recombinant-spider-eggcase-silk-spheres-via-an-hfip-on-oil-approach
#9
Jianming Chen, Jinlian Hu, Peijun Zuo, Jingyu Shi, Mo Yang
Versatile spider silk proteins have been prepared by various methods in morphology of spheres for functional applications. Inspired from natural spinning process, a facile approach for the fabrication of silk spheres is described. Distinct from the traditional emulsification method, silk spheres were assembled as rapidly as 10 s by using the HFIP-on-Oil method without any surfactants and agitation used. Notably, a series of factors, such as evaporation rate of HFIP, polarity and molecular weight of oils play central roles on the final silk morphologies...
May 18, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29782945/advances-in-the-slow-freezing-cryopreservation-of-microencapsulated-cells
#10
REVIEW
H Gurruchaga, L Saenz Del Burgo, R M Hernandez, G Orive, C Selden, B Fuller, J Ciriza, J L Pedraz
Over the past few decades, the use of cell microencapsulation technology has been promoted for a wide range of applications as sustained drug delivery systems or as cells containing biosystems for regenerative medicine. However, difficulty in their preservation and storage has limited their availability to healthcare centers. Because the preservation in cryogenic temperatures poses many biological and biophysical challenges and that the technology has not been well understood, the slow cooling cryopreservation, which is the most used technique worldwide, has not given full measure of its full potential application yet...
May 18, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29782911/estrogen-deficiency-exacerbates-a%C3%AE-induced-memory-impairment-through-enhancement-of-neuroinflammation-amylodogenesis-and-nf-%C3%A4-b-activation-in-ovariectomized-mice
#11
Jaesuk Yun, In Jun Yeo, Chul Ju Hwang, Dong-Young Choi, Hyung-Sik Im, Ji Youg Kim, Won Rak Choi, Myung Hee Jung, Sang-Bae Han, Jin Tae Hong
Estrogen is well known to have a preventative effect in Alzheimer's disease (AD) pathology. Several studies have demonstrated that nuclear factor kappa-B (NF-ĸB) can contribute to the effects of estrogen on the development of AD. We investigated whether NF-ĸB affects amyloid-beta (Aβ)-induced memory impairment in an estrogen-lacking condition. In the present study, nine-week-old Institute cancer research (ICR) mice were ovariectomized to block estrogen stimulation. Ten weeks after the ovariectomization, mice were administered with Aβ (300 pmol) via intracerebroventricular (ICV) infusion for 2 weeks...
May 18, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29782826/sheets-of-human-retinal-progenitor-transplants-improve-vision-in-rats-with-severe-retinal-degeneration
#12
Bin Lin, Bryce T McLelland, Anuradha Mathur, Robert B Aramant, Magdalene J Seiler
Loss of photoreceptors and other retinal cells is a common endpoint in retinal degenerate (RD) diseases that cause blindness. Retinal transplantation is a potential therapy to replace damaged retinal cells and improve vision. In this study, we examined the development of human fetal retinal sheets with or without their retinal pigment epithelium (RPE) transplanted to immunodeficient retinal degenerate rho S334ter-3 rats. Sheets were dissected from fetal human eyes (11-15.7 weeks gestation) and then transplanted to the subretinal space of 24-31 d old RD nude rats...
May 18, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29782821/licoricidin-enhances-gemcitabine-induced-cytotoxicity-in-osteosarcoma-cells-by-suppressing-the-akt-and-nf-%C3%AE%C2%BAb-signal-pathways
#13
Yifei Wang, Shengli Wang, Jianhua Liu, Yanxiao Lu, Donghui Li
Osteosarcoma (OS) is the most common bone malignancy in children and adolescents. Combined treatments of anti-cancer drugs can remarkably improve chemotherapeutic outcomes. Gemcitabine and licoricidin both have potential anti-tumor activity in several cancers. However, the combined therapeutic efficiency of gemcitabine and licoricidin for OS has not been explored. Here, we found that licoricidin or gemcitabine inhibited OS cell viability in a dose-dependent manner. Cotreatment with licoricidin and gemcitabine enhanced gemcitabine-induced cytotoxicity in OS cells...
May 18, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29782809/the-effects-of-normal-aging-on-regional-accumulation-of-hyaluronan-and-chondroitin-sulfate-proteoglycans-in-the-mouse-brain
#14
May J Reed, Mamatha Damodarasamy, Jasmine L Pathan, Michelle A Erickson, William A Banks, Robert B Vernon
The brain changes in volume and composition with normal aging. Cellular components of the brain are supported by an extracellular matrix (ECM) comprised largely of hyaluronan (HA) and HA-associated members of the lectican family of chondroitin sulfate proteoglycans (CSPGs). We examined regional differences in microvascular density, neuronal and glial markers, and accumulation of HA and CSPGs in mouse brains during normal aging. The cortex, hippocampus, dentate gyrus, and cerebellum of young (4 months), middle-aged (14 months), and aged (24-26 months) brains were analyzed...
May 1, 2018: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/29782791/a-method-for-preparation-of-an-internal-layer-of-artificial-vascular-graft-co-modified-with-salvianolic-acid-b-and-heparin
#15
Haizhu Kuang, Yao Wang, Junfeng Hu, Chunsheng Wang, Shuyang Lu, Xiumei Mo
Studies have shown that traditional Chinese medicine Salvianolic acid B (SAB) can promote the proliferation and migration of endothelial cells. Heparin has a good anticoagulant effect. The inner layer of artificial vascular graft is fabricated by coaxial electrospinning method, and loaded with heparin and SAB. The release of heparin and SAB was sustained for almost 30 days, and SAB without initial burst release. Furthermore, the combined effect of SAB and heparin contributed to promoted Human Umbilical Vein Endothelial Cells (HUVECs) growth and improved blood compatibility of graft...
May 21, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29782698/morphology-regulation-in-redox-destructible-amphiphilic-block-copolymers-and-impact-on-intracellular-drug-delivery
#16
Raju Bej, Jayita Sarkar, Debes Ray, Vinod K Aswal, Suhrit Ghosh
In two ABA type amphiphilic block copolymers (P1, P2), the hydrophobic B block consists of a bioreducible segmented poly(disulfide) (PDS), while poly-N-isopropylacrylamide (PNIPAM) or poly(triethyleneglycol)methylether-methacrylate (PTEGMA) serve as the hydrophilic A blocks in P1 and P2, respectively, leading to the formation of polymersome and micelle, owing to the difference in the packing parameters. Both exhibit comparable doxorubicin (Dox) encapsulation efficiency, but glutathione (GSH) triggered release appears much faster from the polymersome than micelle owing to the complete degradation of the PDS segment in polymersome morphology unlike in micelle...
May 21, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29782681/highly-efficient-nonfullerene-polymer-solar-cells-enabled-by-a-copper-i-coordination-strategy-employing-an-1-3-4-oxadiazole-containing-wide-bandgap-copolymer-donor
#17
Xiaopeng Xu, Zuojia Li, Zhaozhao Bi, Ting Yu, Wei Ma, Kui Feng, Ying Li, Qiang Peng
A novel wide-bandgap copolymer of PBDT-ODZ based on benzo[1,2-b:4,5-b' ]dithiophene (BDT) and 1,3,4-oxadiazole (ODZ) blocks is developed for efficient nonfullerene polymer solar cells (NF-PSCs). PBDT-ODZ exhibits a wide bandgap of 2.12 eV and a low-lying highest occupied molecular orbital (HOMO) level of -5.68 eV, which could match well with the low-bandgap acceptor of 3,9-bis(2-methylene-(3-(1,1-dicyanomethylene)-indanone)-5,5,11,11-tetrakis(4-hexylthienyl)-dithieno[2,3-d:2',3'-d']-s-indaceno[1,2-b:5,6-b']-dithiophene (ITIC-Th), inducing a good complementary absorption from 300 to 800 nm and a minimal HOMO level offset (0...
May 21, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29782668/high-efficiency-all-small-molecule-organic-solar-cells-based-on-an-organic-molecule-donor-with-alkylsilyl-thienyl-conjugated-side-chains
#18
Haijun Bin, Jia Yao, Yankang Yang, Indunil Angunawela, Chenkai Sun, Liang Gao, Long Ye, Beibei Qiu, Lingwei Xue, Chenhui Zhu, Chunhe Yang, Zhi-Guo Zhang, Harald Ade, Yongfang Li
Two medium-bandgap p-type organic small molecules H21 and H22 with an alkylsily-thienyl conjugated side chain on benzo[1,2-b:4,5-b']dithiophene central units are synthesized and used as donors in all-small-molecule organic solar cells (SM-OSCs) with a narrow-bandgap n-type small molecule 2,2'-((2Z,2'Z)-((4,4,9,9-tetrahexyl-4,9-dihydro-s-indaceno[1,2-b:5,6-b']dithiophene-2,7-diyl)bis(methanylylidene))bis(3-oxo-2,3-dihydro-1H-indene-2,1-diylidene))dimalononitrile (IDIC) as the acceptor. In comparison to H21 with 3-ethyl rhodanine as the terminal group, H22 with cyanoacetic acid esters as the terminal group shows blueshifted absorption, higher charge-carrier mobility and better 3D charge pathway in blend films...
May 21, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29782621/darpp-32-and-t-darpp-promote-non-small-cell-lung-cancer-growth-through-regulation-of-ikk%C3%AE-dependent-cell-migration
#19
Sk Kayum Alam, Matteo Astone, Ping Liu, Stephanie R Hall, Abbygail M Coyle, Erin N Dankert, Dane K Hoffman, Wei Zhang, Rui Kuang, Anja C Roden, Aaron S Mansfield, Luke H Hoeppner
Lung cancer is the leading cause of cancer-related death worldwide. Here we demonstrate that elevated expression of dopamine and cyclic adenosine monophosphate-regulated phosphoprotein, Mr 32000 (DARPP-32) and its truncated splice variant t-DARPP promote lung tumor growth, while abrogation of DARPP-32 expression in human non-small cell lung cancer (NSCLC) cells reduces tumor growth in orthotopic mouse models. We observe a novel physical interaction between DARPP-32 and inhibitory kappa B kinase-α (IKKα) that promotes NSCLC cell migration through non-canonical nuclear factor kappa-light-chain-enhancer of activated B cells 2 (NF-κB2) signaling...
2018: Commun Biol
https://www.readbyqxmd.com/read/29782552/role-of-kinesins-in-directed-adenovirus-transport-and-cytoplasmic-exploration
#20
Jie Zhou, Julian Scherer, Julie Yi, Richard B Vallee
Many viruses, including adenovirus, exhibit bidirectional transport along microtubules following cell entry. Cytoplasmic dynein is responsible for microtubule minus end transport of adenovirus capsids after endosomal escape. However, the identity and roles of the opposing plus end-directed motor(s) remain unknown. We performed an RNAi screen of 38 kinesins, which implicated Kif5B (kinesin-1 family) and additional minor kinesins in adenovirus 5 (Ad5) capsid translocation. Kif5B RNAi markedly increased centrosome accumulation of incoming Ad5 capsids in human A549 pulmonary epithelial cells within the first 30 min post infection, an effect dramatically enhanced by blocking Ad5 nuclear pore targeting using leptomycin B...
May 21, 2018: PLoS Pathogens
keyword
keyword
42602
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"