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Lymphedema

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https://www.readbyqxmd.com/read/28101567/influence-of-arm-crank-ergometry-on-development-of-lymphedema-in-breast-cancer-patients-after-axillary-dissection-a-randomized-controlled-trail
#1
Thorsten Schmidt, Jette Berner, Walter Jonat, Burkhard Weisser, Christioph Röcken, Marion van Mackelenbergh, Christoph Mundhenke
OBJECTIVE: To investigate the safety and efficacy of arm crank ergometry in breast cancer patients after axillary lymph node dissection, with regard to changes in bioelectrical impedance analysis, arm circumference, muscular strength, quality of life and fatigue. DESIGN: Randomized controlled clinical intervention trial. SUBJECTS: Forty-nine patients with breast cancer after axillary lymph node dissection. METHODS: Arm crank ergometer training twice-weekly was compared with usual care over 12 weeks...
January 19, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28099357/bilayered-negative-pressure-wound-therapy-preventing-leg-incision-morbidity-in-coronary-artery-bypass-graft-patients-a-randomized-controlled-trial
#2
Yongchao Yu, Zhigang Song, Zhiyun Xu, Xiaofei Ye, Chunyu Xue, Junhui Li, Hongda Bi
BACKGROUNDS: The harvesting of great saphenous veins for coronary artery bypass graft (CABG) patients may result in significant complications, including lymphorrhagia, lymphoedema, incision infection, wound dehiscence, and skin flap necrosis. We investigated the function of a self-designed bilayered negative pressure wound therapy (b-NPWT) for reducing the above-mentioned complications using a clinical randomized controlled trial. METHODS: A single-center, pilot randomized controlled trial was conducted...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28097676/morbihan-disease-complicated-by-dermatosis-neglecta-a-unique-presentation
#3
Ariel E Eber, Stephanie Mlacker, Sebastian Verne, Robert Griffith, Jennifer Ledon, Marina Perper, Keyvan Nouri, Jeong Hee Cho-Vega
Morbihan disease (MD), also referred to as solid facial edema, or rosacea lymphedema, is a rare disorder that involves chronic erythema and solid edema of the cheeks, eyelids, forehead and glabella and may arise as a complication of acne vulgaris or rosacea. Of note, it may be the only initial presenting symptom of these associated diseases.1,2 Few cases have been described in the literature, since its first description by Robert Degos in 1957. The condition is characterized by its chronicity, a typical clinical appearance, and the lack of specific histopathologic or laboratory findings...
January 18, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28094037/identifying-risk-factors-for-occult-lower-extremity-lymphedema-using-computed-tomography-in-patients-undergoing-lymphadenectomy-for-gynecologic-cancers
#4
Miseon Kim, Dong Hoon Suh, Eun Joo Yang, Myong Cheol Lim, Jin Young Choi, Kidong Kim, Jae Hong No, Yong-Beom Kim
OBJECTIVE: To identify risk factors for lower extremity lymphedema (LEL) using computed tomographic (CT) scan in patients undergoing lymphadenectomy for gynecologic cancers. METHODS: We retrospectively reviewed 511 consecutive gynecologic cancer patients undergoing lymphadenectomy. Mean difference (3.77±3.14mm) of subcutaneous layer thicknesses between preoperative and postoperative 1-year CT scans of 106 patients with clinical LEL was used as an objective criterion for regrouping all the patients into those with mean difference >3...
January 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28092183/therapeutic-effects-of-hyaluronidase-on-acquired-lymphedema-using-a-newly-developed-mouse-limb-model
#5
Kangsan Roh, Sungrae Cho, Jae-Hyun Park, Byong Chul Yoo, Won-Ki Kim, Seok-Ki Kim, Kyewon Park, Hee Kang, Jin-Mo Ku, Chang-Hwan Yeom, Kyunghoon Lee, Sukchan Lee
Acquired lymphedema is one of the most dreaded side effects of cancer treatment, such as surgical treatment or irradiation. However, due to the lack of appropriate animal models, there is no effective therapeutic method to cure acquired lymphedema. To develop a reproducible acquired lymphedema animal model, we devised a mouse hind limb model by removing a superficial inguinal lymph node, a popliteal lymph node, a deep inguinal lymph node, and the femoral lymphatic vessel. We measured the volume of lymphedematous leg and observed the change in level of hyaluronic acid (HA) and lymphangiogenic factors after injecting hyaluronidase...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28073151/ccbe1-mutation-causing-sclerosing-cholangitis-expanding-the-spectrum-of-lymphedema-cholestasis-syndrome
#6
André Viveiros, Marion Reiterer, Benedikt Schaefer, Armin Finkenstedt, Stefan Schneeberger, Hubert Schwaighofer, Patrizia Moser, Rudolf Sprenger, Bernhard Glodny, Wolfgang Vogel, Andreas R Janecke, Heinz Zoller
No abstract text is available yet for this article.
January 10, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28070472/utilizing-the-veraflo%C3%A2-instillation-negative-pressure-wound-therapy-system-with-advanced-care-for-a-case-study
#7
Rita K Driver
BACKGROUND:  Mankind has always suffered wounds throughout time due to trauma, disease, and lifestyles. Many wounds are non-healing and have continued to be challenging. However, utilizing advanced wound care treatments, such as negative pressure wound treatment with instillation and dwell time (NPWTi-d), has proven beneficial. NPWTi-d is indicated in a variety of wounds, such as trauma, surgical, acute, pressure injuries, diabetic foot ulcers, and venous leg ulcers. Bacteria and bioburden interrupts wound healing by increasing the metabolic needs, ingesting, and robbing the necessary nutrients and oxygen...
November 30, 2016: Curēus
https://www.readbyqxmd.com/read/28058777/platysma-sparing-vascularized-submental-lymph-node-flap-transfer-for-extremity-lymphedema
#8
Igor Poccia, Chia-Yu Lin, Ming-Huei Cheng
BACKGROUND AND OBJECTIVES: Due to its consistent vascular and lymphatic anatomy, the vascularized submental lymph node flap is a reliable option for lymphedema treatment. Despite these advantages, flap harvest requires resection of platysma, which may cause a marginal mandibular nerve pseudo-paralysis. The aim of this study was to investigate the donor site morbidity of an innovative platysma-sparing vascularized submental lymph node flap transfer for treating extremity lymphedema. METHODS: Ten patients undergoing platysma sparing submental lymph-node flap harvest were prospectively enrolled in the study and compared with a control group of 10 patients who underwent standard submental lymph-node flap harvest...
January 6, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28055225/overexpression-of-prox1-induces-the-differentiation-of-human-adipose-derived-stem-cells-into-lymphatic-endothelial-like-cells-in-vitro
#9
Jingcheng Deng, Tingting Dai, Yiyu Sun, Qi Zhang, Zhaohua Jiang, Shengli Li, Weigang Cao
Constant levels of homeobox transcription factor Prox1 expression are required throughout the life of lymphatic endothelial cells (LECs) to maintain their differentiated identity. Recent studies have demonstrated that using human LECs for cell transplantation therapy may improve secondary lymphedema in a nude rat model. However, the application is currently limited by the low yield of LECs. In this study, Prox1 was overexpressed in human adipose tissue-derived stem cells (hADSCs) by using the transfection of lentiviral vectors to induce the differentiation of hADSCs to LECs...
January 5, 2017: Cellular Reprogramming
https://www.readbyqxmd.com/read/28054496/tailoring-exercise-interventions-to-comorbidities-and-treatment-induced-adverse-effects-in-patients-with-early-stage-breast-cancer-undergoing-chemotherapy-a-framework-to-support-clinical-decisions
#10
Marike van der Leeden, Rosalie J Huijsmans, Edwin Geleijn, Mariëtte de Rooij, Inge R Konings, Laurien M Buffart, Joost Dekker, Martijn M Stuiver
PURPOSE: Delivery of exercise interventions to patients with early-stage breast cancer undergoing chemotherapy requires complex clinical decisions. The purpose of this study was to develop a framework to support clinical decisions for tailoring exercise interventions to common comorbidities and cancer treatment-induced adverse effects. METHOD: Tailored exercise prescriptions were developed in four steps, following the i3-S strategy. All steps were based on current best available evidence, complemented with expert opinions...
January 5, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28052649/prognostic-impact-of-elective-supraclavicular-nodal-irradiation-for-patients-with-n1-breast-cancer-after-lumpectomy-and-anthracycline-plus-taxane-based-chemotherapy-krog-1418-a-multicenter-case-controlled-study
#11
Haeyoung Kim, Won Park, Jeong Il Yu, Doo Ho Choi, Seung Jae Huh, Yeon-Joo Kim, Eun Sook Lee, Keun Seok Lee, Han-Sung Kang, In Hae Park, Kyung Hwan Shin, Chan Woo Wee, Kyubo Kim, Kyung Ran Park, Yong Bae Kim, Sung Ja Ahn, Jong Hoon Lee, Jin Hee Kim, Mison Chun, Hyung-Sik Lee, Jung Soo Kim, Jihye Cha
Purpose: This study was conducted to evaluate the impact of supraclavicular lymph node radiotherapy (SCNRT) on N1 breast cancer patients receiving post-lumpectomy whole-breast irradiation (WBI) and anthracycline plus taxane-based (AT) chemotherapy. Materials and Methods: We performed a case-control analysis to compare the outcomes of WBI and WBI plus SCNRT (WBI+SCNRT). Among 1,147 patients with N1 breast cancer who received post-lumpectomy radiotherapy and AT-based chemotherapy in 12 hospitals, 542 were selected after propensity score matching...
January 4, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28052379/supermicrosurgical-lymphaticovenous-anastomosis-for-a-patient-with-breast-lymphedema-secondary-to-breast-cancer-treatment
#12
Guido Giacalone, Takumi Yamamoto
Breast lymphedema (BLE) has been reported as a complication following breast cancer treatment. As for extremity lymphedema treatment, supermicrosurgical lymphaticovenous anastomosis (LVA) is considered an option for the treatment of progressive BLE refractory to conservative treatments, but no case has been reported so far. We report the first case of BLE successfully treated with supermicrosurgical LVA. A 55-year-old female presented with left BLE after breast conserving surgery and axillary lymph node dissection and adjuvant radiotherapy...
January 3, 2017: Microsurgery
https://www.readbyqxmd.com/read/28033224/skeletal-scintigraphy-in-radiation-induced-fibrosis-with-lymphedema
#13
Jieqi Wang, Arya M Iranmanesh, M Elizabeth Oates
Despite increasing reliance on CT, MRI, and FDG PET/CT for oncological imaging, whole-body skeletal scintigraphy remains a frontline modality for staging and surveillance of osseous metastatic disease. We present a 54-year-old woman with metastatic breast cancer who received palliative external-beam radiation to the left ilium. Serial follow-up Tc-MDP bone scans demonstrated progressive soft-tissue uptake in her left lower extremity, extending from thigh to leg, with associated enlargement and skin thickening, consistent with lymphedema related to radiation-induced fibrosis...
December 28, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28028991/computed-tomography-based-quantitative-assessment-of-lower-extremity-lymphedema-following-treatment-for-gynecologic-cancer
#14
Ji Sung Yoo, Seung Hyun Chung, Myong Cheol Lim, Young Jae Kim, Kwang Gi Kim, Ji Hye Hwang, Yun Hee Kim
OBJECTIVE: To develop an algorithmic quantitative skin and subcutaneous tissue volume measurement protocol for lower extremity lymphedema (LEL) patients using computed tomography (CT), to verify the usefulness of the measurement techniques in LEL patients, and to observe the structural characteristics of subcutaneous tissue according to the progression of LEL in gynecologic cancer. METHODS: A program for algorithmic quantitative analysis of lower extremity CT scans has been developed to measure the skin and subcutaneous volume, muscle compartment volume, and the extent of the peculiar trabecular area with a honeycombed pattern...
December 7, 2016: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28027235/establishment-of-an-acquired-lymphedema-model-in-the-mouse-hindlimb-technical-refinement-and-molecular-characteristics
#15
Daisuke Iwasaki, Yuhei Yamamoto, Naoki Murao, Akihiko Oyama, Emi Funayama, Hiroshi Furukawa
BACKGROUND: The pathophysiology of secondary lymphedema remains poorly understood. This study aimed to establish a consistent mouse hindlimb lymphedema model for further investigation of the mechanism and treatment of lymphedema. METHODS: The authors developed a novel postsurgical lymphedema model in the mouse hindlimb by modifying previously described methods. Lymphedema in the hindlimb was created by removing both the inguinal and popliteal lymph nodes together with the surrounding fat pads, followed by silicone splint placement in the inguinal region...
January 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28025009/peri-operative-care-for-patients-undergoing-lymphaticovenular-anastomosis-a-systematic-review
#16
REVIEW
Harm Winters, Hanneke J P Tielemans, Philippe N Sprangers, Dietmar J O Ulrich
BACKGROUND: Lymphaticovenular anastomosis (LVA) is a supermicrosurgical procedure that involves the anastomosis of a functional lymphatic channel to a venule. Although peri-operative care might be an important contributor to the success of this technique, evidence about optimal peri-operative care seems limited. This review aims to summarize the peri-operative methods used by authors reporting on LVA. METHODS: A systematic search of the literature was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines...
November 27, 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28018504/skin-and-subcutaneous-tissue-ultrasonography-features-in-breast-cancer-related-lymphedema
#17
Kotaro Suehiro, Noriyasu Morikage, Osamu Yamashita, Takasuke Harada, Makoto Samura, Yuriko Takeuchi, Takahiro Mizoguchi, Kaori Nakamura, Kimikazu Hamano
Objective: To investigate skin, subepidermal low echogenic band (SELEB), and subcutaneous tissue (SCT) thickness as well as the degree of increase in subcutaneous echogenicity (SEG) and subcutaneous echo-free space (SEFS) in arms with lymphedema (LE). Materials and Methods: The skin and SCT of both arms of 30 patients with unilateral stage II breast cancer-related LE were scanned at five points (medial/lateral upper arm/forearm and dorsum of the hand). SEG and SEFS grades were determined according to severity (range: 0-2)...
2016: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/28012086/radiation-therapy-targets-and-the-risk-of-breast-cancer-related-lymphedema-a-systematic-review-and-network-meta-analysis
#18
REVIEW
Simona F Shaitelman
PURPOSE: New indications have been found for regional nodal irradiation (RNI) in breast cancer treatment, yet the relationship of RNI and lymphedema risk is uncertain. We sought to determine the association of RNI and lymphedema. METHODS: We searched MEDLINE, EMBASE, and Scopus for articles in English on humans published from 1995 to 2015, using search terms breast neoplasm, treatment, and morbidity. Two investigators independently selected articles and extracted information, including manuscripts reporting incidence of lymphedema by radiation targets...
December 23, 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28009597/a-review-of-treatment-for-breast-cancer-related-lymphedema-paradigms-for-clinical-practice
#19
Timothy D Smile, Rahul Tendulkar, Graham Schwarz, Douglas Arthur, Stephen Grobmyer, Stephanie Valente, Frank Vicini, Chirag Shah
OBJECTIVES: Breast cancer-related lymphedema (BCRL) represents a major complication of breast cancer treatment, impacting the quality of life for breast cancer survivors that develop it. The purpose of this review is to evaluate the literature surrounding BCRL treatment modalities to guide clinicians regarding risk-stratified treatment options. METHODS: A review of studies over a 10-year period (January 2006 to February 2016) was performed. Noninvasive strategies evaluated included compression therapy, manual lymphatic drainage, and complex decongestive therapy (CDT)...
December 22, 2016: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28008557/the-effects-of-complex-exercise-on-shoulder-range-of-motion-and-pain-for-women-with-breast-cancer-related-lymphedema-a-single-blind-randomized-controlled-trial
#20
Jin-Hyuck Park
BACKGROUND: This study was to investigate the effects of complex exercise on shoulder range of motion and pain for women with breast cancer-related lymphedema. METHODS: 69 women participated in this study and then they were randomly allocated to complex exercise group (n = 35) or the conventional decongestive therapy group (n = 34). All subjects received 8 sessions for 4 weeks. To identify the effects on shoulder range of motion and pain, goniometer and visual analog scale were used, respectively...
December 23, 2016: Breast Cancer: the Journal of the Japanese Breast Cancer Society
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