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https://www.readbyqxmd.com/read/29352714/effect-of-single-agent-daily-prednisone-on-outcomes-and-toxicities-in-metastatic-castration-resistant-prostate-cancer-pooled-analysis-of-prospective-studies
#1
REVIEW
Pooja Ghatalia, Gregory R Pond, Arnoud J Templeton, Guru Sonpavde
The clinical effect of prednisone in metastatic castration-resistant prostate cancer (mCRPC) is unknown. We performed a pooled analysis of control arms of randomized controlled trials that had or had not administered single-agent prednisone. Randomized controlled trials with a control arm that included single-agent placebo (or no anticancer therapy) or single-agent prednisone (with or without placebo) were eligible for analysis. Patients receiving prednisone combined with other agents in the control arm were excluded...
December 27, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29352713/clinical-variables-associated-with-overall-survival-in-metastatic-castration-resistant-prostate-cancer-patients-treated-with-sipuleucel-t-immunotherapy
#2
Xiao X Wei, Jaselle Perry, Emily Chang, Li Zhang, Robert A Hiatt, Charles J Ryan, Eric J Small, Lawrence Fong
BACKGROUND: Sipuleucel-T is an autologous cell-based cancer immunotherapy for men with asymptomatic or minimally symptomatic metastatic castration-resistant prostate cancer (mCRPC). Its approval by the Food and Drug Administration was based on demonstration of an overall survival (OS) benefit in randomized placebo-controlled phase III trials. However, treatment was associated with a prostate-specific antigen (PSA) decline in only a small minority of patients. Understanding the clinical factors that are associated with OS could help guide treatment decisions, including patient selection and the timing of sipuleucel-T relative to other therapies...
December 27, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29352703/inotuzumab-ozogamicin-in-combination-with-low-intensity-chemotherapy-for-older-patients-with-philadelphia-chromosome-negative-acute-lymphoblastic-leukaemia-a-single-arm-phase-2-study
#3
Hagop Kantarjian, Farhad Ravandi, Nicholas J Short, Xuelin Huang, Nitin Jain, Koji Sasaki, Naval Daver, Naveen Pemmaraju, Joseph D Khoury, Jeffrey Jorgensen, Yesid Alvarado, Marina Konopleva, Guillermo Garcia-Manero, Tapan Kadia, Musa Yilmaz, Gautam Bortakhur, Jan Burger, Steven Kornblau, William Wierda, Courtney DiNardo, Alessandra Ferrajoli, Jovitta Jacob, Rebecca Garris, Susan O'Brien, Elias Jabbour
BACKGROUND: Inotuzumab ozogamicin, an anti-CD22 monoclonal antibody bound to a toxin, calicheamicin, has shown single-agent activity in relapsed or refractory acute lymphoblastic leukaemia. We aimed to assess the activity and safety of inotuzumab ozogamicin in combination with low-intensity chemotherapy in older patients with acute lymphoblastic leukaemia. METHODS: We did a single-arm, phase 2 study at the MD Anderson Cancer Center (Houston, TX, USA). Eligible patients were aged 60 years or older and had newly diagnosed, Philadelphia chromosome-negative, acute lymphoblastic leukaemia, and an Eastern Cooperative Oncology Group performance status of 3 or lower...
January 15, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29352356/assessment-of-noise-level-and-noise-propagation-generated-by-light-lift-helicopters-in-mountain-natural-environments
#4
Stefano Grigolato, Omar Mologni, Andrea Rosario Proto, Giuseppe Zimbalatti, Raffaele Cavalli
The use of helicopter rises discussion about environmental noise propagation especially when it operates in proximity of environmentally sensitive areas (ESAs) for an extended period because of its potential implications in wildlife behaviours. In order to support decisions on helicopter logging operation management in proximity of ESAs, this study focused on (i) analysing the noise spectrum of a light-lift helicopter during logging operations and on (ii) assessing the noise propagation in the surrounding environments...
January 20, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29352350/groundwater-quality-assessment-in-semi-arid-regions-using-integrated-approaches-the-case-of-grombalia-aquifer-ne-tunisia
#5
Siwar Kammoun, Rim Trabelsi, Viviana Re, Kamel Zouari, Jihed Henchiri
As many arid and semi-arid regions in the Mediterranean Basin, the Grombalia coastal aquifer (NE Tunisia) is affected by severe groundwater exploitation and contamination. Therefore, quality assessments are becoming increasingly important as the long-term protection of water resources is at stake. Multidisciplinary investigations, like the one presented in this paper, are particularly effective in identifying the different origins of mineralization within an aquifer and investigating the impact of anthropogenic activities on groundwater quality...
January 19, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29352197/phylogenetic-and-functional-structure-of-wintering-waterbird-communities-associated-with-ecological-differences
#6
Xianli Che, Min Zhang, Yanyan Zhao, Qiang Zhang, Qing Quan, Anders Møller, Fasheng Zou
Ecological differences may be related to community component divisions between Oriental (west) and Sino-Japanese (east) realms, and such differences may result in weak geographical breaks in migratory species that are highly mobile. Here, we conducted comparative phylogenetic and functional structure analyses of wintering waterbird communities in southern China across two realms and subsequently examined possible climate drivers of the observed patterns. An analysis based on such highly migratory species is particularly telling because migration is bound to reduce or completely eliminate any divergence between communities...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29351786/factors-associated-with-intended-use-of-a-maternity-waiting-home-in-southern-ethiopia-a-community-based-cross-sectional-study
#7
Tienke Vermeiden, Floris Braat, Girmay Medhin, Asheber Gaym, Thomas van den Akker, Jelle Stekelenburg
BACKGROUND: Although Ethiopia is scaling up Maternity Waiting Homes (MWHs) to reduce maternal and perinatal mortality, women's use of MWHs varies markedly between facilities. To maximize MWH utilization, it is essential that policymakers are aware of supportive and inhibitory factors. This study had the objective to describe factors and perceived barriers associated with potential utilization of an MWH among recently delivered and pregnant women in Southern Ethiopia. METHODS: A community-based cross-sectional study was conducted between March and November 2014 among 428 recently delivered and pregnant women in the Eastern Gurage Zone, Southern Ethiopia, where an MWH was established for high-risk pregnant women to await onset of labour...
January 19, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29351314/species-richness-of-eurasian-zephyrus-hairstreaks-lepidoptera-lycaenidae-theclini-with-implications-on-historical-biogeography-an-ndm-vndm-approach
#8
Hailing Zhuang, Masaya Yago, Josef Settele, Xiushan Li, Rei Ueshima, Nick V Grishin, Min Wang
AIM: A database based on distributional records of Eurasian Zephyrus hairstreaks (Lepidoptera: Lycaenidae: Theclini) was compiled to analyse their areas of endemism (AoEs), species richness and distribution patterns, to explore their locations of past glacial refugia and dispersal routes. METHODS: Over 2000 Zephyrus hairstreaks occurrences are analysed using the NDM/VNDM algorithm, for the recognition of AoEs. Species richness was calculated by using the option 'Number of different classes' to count the different classes of a variable presented in each 3...
2018: PloS One
https://www.readbyqxmd.com/read/29351205/influence-of-grapevine-cultivar-on-the-second-generations-of-lobesia-botrana-and-eupoecilia-ambiguella
#9
Francesco Pavan, Giorgio Stefanelli, Alberto Villani, Elena Cargnus
Grapevine cultivar can affect susceptibility to Lobesia botrana and Eupoecilia ambiguella with important implications on control strategies. A four-year study was carried out in north-eastern Italy on 10 cultivars (Cabernet Sauvignon, Carménère, Chardonnay, Merlot, Refosco dal Peduncolo Rosso, Rhine Riesling, Sauvignon Blanc, Terrano, Tocai Friulano and Verduzzo Friulano) grown in the same vineyard to assess whether the cultivar affects second-generation population levels of the two vine moths and L. botrana larval age composition...
January 19, 2018: Insects
https://www.readbyqxmd.com/read/29351059/nematode-thelazia-callipaeda-is-spreading-across-europe-the-first-survey-of-red-foxes-from-slovakia
#10
Viktória Čabanová, Martina Miterpáková, Martin Oravec, Zuzana Hurníková, Slavomír Jerg, Gabriela Nemčíková, Michaela Brincko Červenská
Canine thalaziosis caused by the spirurid nematode Thelazia callipaeda has started to spread across Western and Central Europe during the last decade. In Slovakia, the first autochthonous cases of this infection were recorded in 2016 in four dogs from the south-eastern part of the country. In August 2017 other autochthonous case, again from the same locality, was reported. Seeing that red foxes are considered the main reservoir hosts for T. callipaeda, their examination could provide an integrated view of the real parasite distribution...
March 26, 2018: Acta Parasitologica
https://www.readbyqxmd.com/read/29351020/a-dynamic-state-model-of-migratory-behavior-and-physiology-to-assess-the-consequences-of-environmental-variation-and-anthropogenic-disturbance-on-marine-vertebrates
#11
Enrico Pirotta, Marc Mangel, Daniel P Costa, Bruce Mate, Jeremy A Goldbogen, Daniel M Palacios, Luis A Hückstädt, Elizabeth A McHuron, Lisa Schwarz, Leslie New
Integrating behavior and physiology is critical to formulating new hypotheses on the evolution of animal life-history strategies. Migratory capital breeders acquire most of the energy they need to sustain migration, gestation, and lactation before parturition. Therefore, when predicting the impact of environmental variation on such species, a mechanistic understanding of the physiology of their migratory behavior is required. Using baleen whales as a model system, we developed a dynamic state variable model that captures the interplay among behavioral decisions, energy, reproductive needs, and the environment...
February 2018: American Naturalist
https://www.readbyqxmd.com/read/29350378/eq-5d-studies-in-cardiovascular-diseases-in-eight-central-and-eastern-european-countries-a-systematic-review-of-the-literature
#12
Paulina Batóg, Fanni Rencz, Márta Péntek, László Gulácsi, Krzysztof J Filipiak, Valentina Prevolnik Rupel, Judit Simon, Valentin Brodszky, Petra Baji, Jakub Závada, Guenka Petrova, Alexandru Rotar, Dominik Golicki
BACKGROUND: The measurement of health-related quality of life (HRQOL) by validated generic instruments, such as EQ-5D, becomes an increasingly important tool for the assessment of health care in a wide range of different diagnoses. AIM: To systematically review EQ-5D literature generated in cardiovascular diseases in eight selected Central and Eastern Europe (CEE) countries. METHODS: A structured literature search was conducted in MEDLINE, EMBASE, Web of Science, CINAHL, PsycINFO, the Cochrane Library and the EuroQol website up to November 2016...
January 19, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29350149/cysticercosis-in-shandong-province-eastern-china
#13
Gongzhen Liu, Yanshen Li, Yong Cui, Bingcheng Huang, Hongfa Wang, Yanping Chen, Jingxuan Kou, Fuyong Wang, Chongxing Zhang, Yong Huang, Yin Li, Meng Wang, Qingkuan Wei, Jin Li, Hui Sun, Kun Yin, Guihua Zhao, Yan Jiang, Xin Mao, Zhenhua Yu, Xin Liu
We analyzed demographic and clinical data and estimated the incidence of cysticercosis in Shandong Province, China, during 1975-2014. Our analyses showed that a cysticercosis-endemic area is present in Shandong Province, especially in its western regions. Improved surveillance and control are needed to address the elevated risk for cysticercosis in this region.
February 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29349727/lifestyles-of-patients-with-functional-psychosis-compared-to-those-of-a-sample-of-the-regional-general-population-findings-from-a-study-in-a-community-mental-health-service-of-the-veneto-region-italy
#14
Loretta Berti, Elena Bonfioli, Linda Chioffi, Susanna Morgante, Maria Angela Mazzi, Lorenzo Burti
Unhealthy lifestyles contribute, with other risk factors, to the high prevalence of mortality and physical comorbidity among mental patients compared to the general population. We collected data on the lifestyles of 193 subjects with psychosis in contact with a Community Mental Health Service in north-eastern Italy and compared them with a representative sample (total: 3219 subjects) of the general population of the same region. Diet, exercise, smoking and alcohol consumption were worse in mental patients. A higher percentage of patients was overweight or obese...
January 18, 2018: Community Mental Health Journal
https://www.readbyqxmd.com/read/29349487/lay-first-responder-training-in-eastern-uganda-leveraging-transportation-infrastructure-to-build-an-effective-prehospital-emergency-care-training-program
#15
Peter G Delaney, Richard Bamuleke, Yang Jae Lee
BACKGROUND: Though road traffic injuries (RTIs) are a major cause of mortality in East Africa, few countries have emergency medical services. The aim was to create a sustainable and efficient prehospital lay first responder program, creating a system with lay first responders spread through the 53 motorcycle taxi stages of Iganga Municipality. METHODS: One hundred and fifty-four motorcycle taxi riders were taught a first aid curriculum in partnership with a local Red Cross first aid trainer and provided with a first aid kit following WHO guidelines for basic first aid...
January 18, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29349294/changes-in-seasonal-snow-water-equivalent-distribution-in-high-mountain-asia-1987-to-2009
#16
Taylor Smith, Bodo Bookhagen
Snow meltwaters account for most of the yearly water budgets of many catchments in High Mountain Asia (HMA). We examine trends in snow water equivalent (SWE) using passive microwave data (1987 to 2009). We find an overall decrease in SWE in HMA, despite regions of increased SWE in the Pamir, Kunlun Shan, Eastern Himalaya, and Eastern Tien Shan. Although the average decline in annual SWE across HMA (contributing area, 2641 × 103 km2) is low (average, -0.3%), annual SWE losses conceal distinct seasonal and spatial heterogeneities across the study region...
January 2018: Science Advances
https://www.readbyqxmd.com/read/29348921/genetic-characteristics-of-vana-type-vancomycin-resistant-enterococcus-faecalis-and-enterococcus-faecium-in-cuba
#17
D Quiñones, M S Aung, J P Sousa Martins, N Urushibara, N Kobayashi
VanA-type vancomycin-resistant enterococci isolates from bloodstream infections in Cuba were genetically characterized. Enterococcus faecalis isolates were assigned to sequence type (ST) 28, closely related to Eastern Europe, while Enterococcus faecium belonged to ST262, ST656 and ST1349, and showed different genetic profiles.
January 2018: New Microbes and New Infections
https://www.readbyqxmd.com/read/29348710/the-protein-tyrosine-phosphatase-nonreceptor-22-ptpn22-r620w-functional-polymorphism-in-psoriasis
#18
Ghaleb Bin Huraib, Fahad Al Harthi, Misbahul Arfin, Sadaf Rizvi, Abdulrahaman Al-Asmari
Background: Psoriasis is a complex autoimmune disease caused by the interaction of genetic and environmental factors. PTPN22 gene polymorphism has been reported to affect psoriasis susceptibility; however, no data are available for Middle Eastern populations. Objective: The aim of this study was to investigate the association of PTPN22 (1858C/T) R620W polymorphism with psoriasis in a Saudi cohort. Methods: Saudi subjects (n = 306) including patients with psoriasis (n = 106) and matched controls (n = 200) were studied for PTPN22 variants using tetra-primer amplification refractory mutation system-polymerase chain reaction method...
2018: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29348642/the-success-of-failed-homo-sapiens-dispersals-out-of-africa-and-into-asia
#19
REVIEW
Ryan J Rabett
The evidence for an early dispersal of Homo sapiens from Africa into the Levant during Marine Isotope Stage 5 (MIS-5) 126-74 ka (thousand years ago) was characterized for many years as an 'abortive' expansion: a precursor to a sustained dispersal from which all extant human populations can be traced. Recent archaeological and genetic data from both western and eastern parts of Eurasia and from Australia are starting to challenge that interpretation. This Perspective reviews the current evidence for a scenario where the MIS-5 dispersal encompassed a much greater geographic distribution and temporal duration...
January 18, 2018: Nature Ecology & Evolution
https://www.readbyqxmd.com/read/29348581/identifying-metabolic-pathways-for-production-of-extracellular-polymeric-substances-by-the-diatom-fragilariopsis-cylindrus-inhabiting-sea-ice
#20
Shazia N Aslam, Jan Strauss, David N Thomas, Thomas Mock, Graham J C Underwood
Diatoms are significant primary producers in sea ice, an ephemeral habitat with steep vertical gradients of temperature and salinity characterizing the ice matrix environment. To cope with the variable and challenging conditions, sea ice diatoms produce polysaccharide-rich extracellular polymeric substances (EPS) that play important roles in adhesion, cell protection, ligand binding and as organic carbon sources. Significant differences in EPS concentrations and chemical composition corresponding to temperature and salinity gradients were present in sea ice from the Weddell Sea and Eastern Antarctic regions of the Southern Ocean...
January 18, 2018: ISME Journal
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