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https://www.readbyqxmd.com/read/28102887/clinical-trial-of-nintedanib-in-patients-with-recurrent-or-metastatic-salivary-gland-cancer-of-the-head-and-neck-a-multicenter-phase-2-study-korean-cancer-study-group-hn14-01
#1
Youjin Kim, Su Jin Lee, Ji Yun Lee, Se-Hoon Lee, Jong-Mu Sun, Keunchil Park, Ho Jung An, Jae Yong Cho, Eun Joo Kang, Ha-Young Lee, Jinsoo Kim, Bhumsuk Keam, Hye Ryun Kim, Kyoung Eun Lee, Moon Young Choi, Ki Hyeong Lee, Myung-Ju Ahn
BACKGROUND: Salivary gland cancers (SGCs) are uncommon and account for less than 5% of all head and neck cancers, but they are histologically heterogeneous. No specific therapy, including targeted agents, has consistently improved clinical outcomes in recurrent/metastatic SGC. Recent studies suggest that vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR) play important roles in SGC. Nintedanib is a potent small-molecule, triple-receptor tyrosine kinase inhibitor (VEGFR1, VEGFR2, and VEGFR3; fibroblast growth factor receptor 1 [FGFR1], FGFR2, and FGFR3; and PDGFRα and PDGFRß)...
January 19, 2017: Cancer
https://www.readbyqxmd.com/read/28102720/do-racial-differences-exist-in-the-association-between-pregnancy-induced-hypertension-and-breast-cancer-risk
#2
Li-Te Lin, Li-Yu Hu, Pei-Ling Tang, Kuan-Hao Tsui, Jiin-Tsuey Cheng, Wei-Chun Huang, Hong-Tai Chang
BACKGROUND: Previous studies investigating the relationship between pregnancy-induced hypertension (PIH) and breast cancer risk have yielded inconsistent results. Unlike numerous Western studies, studies have reported that PIH may be a risk factor for breast cancer in Western Asian women. To confirm these results, we designed a retrospective population-based cohort study to assess the relationship between PIH and subsequent risk for breast cancer in Taiwan. METHODS: Patients with newly diagnosed PIH were selected from the Taiwan National Health Insurance Research Database (NHIRD), and a 1:4 matched cohort of women without PIH based on age and the year of delivery was randomly selected from the same database as the comparison group...
January 19, 2017: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/28102560/the-epidemiology-of-inflammatory-bowel-diseases-from-west-to-east
#3
Zsuzsanna Vegh, Zsuzsanna Kurti, Peter Lakatos
The incidence and prevalence of inflammatory bowel disease (IBD) show considerable variation over time and across geographic regions. The first studies on the epidemiology of IBD were available mainly from traditionally high-incidence areas, as North America and Northern and Western Europe. In the last two decades, more and more data have been reported from Eastern European and Asian counties with increasing incidence rates from some regions. According to recent studies, the high incidence and prevalence of IBD in some Western countries is plateauing and in some Eastern countries increasing incidence rates have been reported...
January 19, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28102505/maternal-characteristics-and-incidence-of-overweight-obesity-in-children-a-13-year-follow-up-study-in-an-eastern-mediterranean-population
#4
Sara Jalali-Farahani, Parisa Amiri, Behnood Abbasi, Mehrdad Karimi, Leila Cheraghi, Maryam Sadat Daneshpour, Fereidoun Azizi
Objectives To investigate clustering of parental sociobehavioral factors and their relationship with the incidence of overweight and obesity in Iranian children. Methods Demographics, body weight, and certain medical characteristics of the parents of 2999 children were used to categorize parents by cluster; children's weights were assessed for each cluster. Specifically, survival analysis and Cox regression models were used to test the effect of parental clustering on the incidence of childhood overweight and obesity...
January 19, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28102290/wells-provide-a-distorted-view-of-life-in-the-aquifer-implications-for-sampling-monitoring-and-assessment-of-groundwater-ecosystems
#5
Kathryn Korbel, Anthony Chariton, Sarah Stephenson, Paul Greenfield, Grant C Hose
When compared to surface ecosystems, groundwater sampling has unique constraints, including limited access to ecosystems through wells. In order to monitor groundwater, a detailed understanding of groundwater biota and what biological sampling of wells truly reflects, is paramount. This study aims to address this uncertainty, comparing the composition of biota in groundwater wells prior to and after purging, with samples collected prior to purging reflecting a potentially artificial environment and samples collected after purging representing the surrounding aquifer...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28102073/estimates-of-health-impacts-and-radiative-forcing-in-winter-haze-in-eastern-china-through-constraints-of-surface-pm2-5-predictions
#6
Meng Gao, Pablo E Saide, Jinyuan Xin, Yuesi Wang, Zirui Liu, Yuxuan Wang, Zifa Wang, Mariusz Pagowski, Sarath K Guttikunda, Gregory R Carmichael
The Gridpoint Statistical Interpolation (GSI) Three-Dimensional Variational (3DVAR) data assimilation system is extended to treat the MOSAIC aerosol model in WRF-Chem, and to be capable of assimilating surface PM2.5 concentrations. The coupled GSI-WRF-Chem system is applied to reproduce aerosol levels over China during an extremely polluted winter month, January 2013. After assimilating surface PM2.5 concentrations, the correlation coefficients between observations and model results averaged over the assimilated sites are improved from 0...
January 19, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28101353/clinical-characteristics-and-treatment-of-69-patients-with-extranodal-natural-killer-t-cell-lymphoma
#7
Yuyan Guo, Enxiao Li, Liping Song, Yinying Wu
This study was conducted to retrospectively analyze the clinical characteristics and survival of patients with extranodal natural killer-T cell lymphoma (ENKL) and compare different treatment regimens. The univariate analysis demonstrated that survival was worse for patients with extranasal primary tumors, Eastern Cooperative Oncology Group performance status (ECOG PS) scores of ≥2, International Prognostic Index (IPI) scores of 3-5, Ann Arbor stage III and IV disease, B symptoms, lymph node involvement and absence of radiotherapy...
December 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28101270/using-online-active-learning-techniques-to-convey-time-compensated-sun-compass-orientation-in-the-eastern-north-american-monarch
#8
Noah H Green, Douglas G McMahon, Cynthia Brame
A common tool that animals use to navigate in a constant direction is known as "time compensated sun compass orientation." This is a process by which animals use the position of the sun along with information from their internal circadian clocks to determine and maintain a directional heading. Many circadian scientists and educators use this process as an example of how the internal circadian clock can directly influence animal behavior. However, many students have difficulty grasping this biological process due to its multivariable nature...
December 2016: Journal of Microbiology & Biology Education: JMBE
https://www.readbyqxmd.com/read/28101218/bevacizumab-pemetrexed-and-carboplatin-in-first-line-treatment-of-non-small-cell-lung-cancer-patients-focus-on-patients-with-brain-metastases
#9
Dimitra Stefanou, Sofia Stamatopoulou, Antigoni Sakellaropoulou, Gavriil Akakios, Marina Gkiaouraki, Despina Gkeka, Maria Prevezanou, Alexandros Ardavanis
Data concerning bevacizumab plus pemetrexed plus carboplatin as first-line treatment for patients with non-squamous non-small cell lung cancer (NSCLC) with or without brain metastases (BM) are lacking. The present study analyzed the efficacy and safety of this combination as induction therapy, followed by maintenance therapy with bevacizumab plus pemetrexed in non-squamous NSCLC patients with or without BM. Treatment-naïve patients with advanced non-squamous NSCLC and an Eastern Cooperative Oncology Group performance status score of 0-2 were eligible...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28100790/genome-wide-analysis-in-brazilians-reveals-highly-differentiated-native-american-genome-regions
#10
Josyf C Mychaleckyj, Alexandre Havt, Uma Nayak, Relana Pinkerton, Emily Farber, Patrick Concannon, Aldo A Lima, Richard L Guerrant
Despite its population, geographic size, and emerging economic importance, disproportionately little genome-scale research exists into genetic factors that predispose Brazilians to disease, or the population genetics of risk. After identification of suitable proxy populations and careful analysis of tri-continental admixture in 1,538 North-Eastern Brazilians to estimate individual ancestry and ancestral allele frequencies, we computed 400,000 genome-wide locus-specific branch length (LSBL) Fst statistics of Brazilian Amerindian ancestry compared to European and African; and a similar set of differentiation statistics for their Amerindian component compared to the closest Asian 1000 Genomes population (surprisingly, Bengalis in Bangladesh)...
January 18, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28100602/find-tuberculosis-strain-bank-a-resource-for-researchers-and-developers-working-on-tests-to-detect-mycobacterium-tuberculosis-and-related-drug-resistance
#11
Belay Tessema, Pamela Nabeta, Eloise Valli, Audrey Albertini, Jimena Collantes, Nguyen Huu Lan, Elena Romancenco, Nestani Tukavdze, Claudia M Denkinger, David L Dolinger
BACKGROUND: The spread of multidrug-resistant tuberculosis and extensively drug-resistant TB hampers the global efforts in the fight against tuberculosis. To enhance the development and evaluation of diagnostic tests quickly and efficiently, well characterized strains and samples from drug resistant tuberculosis patients are necessary. In this project, FIND has focused on the collection, characterization and storage of such well-characterized reference materials and to make them available to researchers and developers...
January 18, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28100557/dual-sensory-impairment-in-special-schools-in-south-eastern-nigeria
#12
Ada E Aghaji, Richard Bowman, Vincent C Ofoegbu, Andrew Smith
In a cross-sectional study to determine the magnitude of dual sensory impairment (DSI-combined hearing and vision loss) in children in single-disability special education schools, children in schools for the blind and schools for the deaf in four states in South-East Nigeria were examined by an ophthalmologist and otorhinolaryngologist to determine the level of their disability and to identify other disabilities if any. Participants were all students with childhood blindness or childhood deafness. The magnitude and causes of DSI and the burden of undetected DSI were the main outcome measures...
February 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28100378/-analysis-on-mortality-of-cervical-cancer-and-its-temporal-trend-in-women-in-china-2006-2012
#13
H L Bao, Y N Liu, L J Wang, L W Fang, S Cong, M G Zhou, L H Wang
Objective: To analyze the mortality of cervical cancer and its temporal trend in women in China between 2006 and 2012. Methods: The cause-of-death data about cervical cancer, which was abstracted from National Disease Surveillance Points and adjusted by special survey for underreporting, was used to analyze the age and area specific crude mortality rates of cervical cancer in China during 2006-2012. The age-standardized mortality rate was calculated by using world standardized population (Segi's). The Joinpoint regression model was used to obtain annual percentage change and 95%CI for assessing the time trend of mortality rate of cervical cancer from 2006 to 2012...
January 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28100373/-epidemiological-characteristics-of-children-aged-1-4-years-without-timely-birth-dose-of-hepatitis-b-vaccine-vaccination-in-china-2014
#14
F Z Wang, G M Zhang, L P Shen, J H Liu, H Zheng, F Wang, N Miao, X J Sun, X F Liang, F Q Cui
Objective: To evaluate the epidemiological characteristics of the children aged 1-4 years without timely birth dose of hepatitis B vaccine (HepB(1)) vaccination. Methods: Based on the data from 160 disease surveillance points in 31 provinces of China, two-stage cluster random sampling was used to select the target population aged 1-4 years. A standard questionnaire was used to collect the information about the birth date, gender, ethnic group, place of birth, HepB immunization history of the children selected...
January 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28100175/do-experiences-with-pregnancy-birth-and-postnatal-care-in-norway-vary-by-the-women-s-geographic-origin-a-comparison-of-cross-sectional-survey-results
#15
Ingeborg S Sjetne, Hilde H Iversen
BACKGROUND: A national survey was conducted to measure and benchmark women's experiences with pregnancy, birth and postnatal care in Norway. The purpose of this secondary analysis is to explore potential variation in these experiences with regard to the survey respondents' geographic origin. METHODS: Data were collected in a national observational cross-sectional study, by a self-administered questionnaire and from registries. The questionnaire collects patient reported experience measures (PREMS) of mainly nontechnical aspects of the health-care services...
January 18, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28100168/effects-of-pleistocene-sea-level-fluctuations-on-mangrove-population-dynamics-a-lesson-from-sonneratia-alba
#16
Yuchen Yang, Jianfang Li, Shuhuan Yang, Xinnian Li, Lu Fang, Cairong Zhong, Norman C Duke, Renchao Zhou, Suhua Shi
BACKGROUND: A large-scale systematical investigation of the influence of Pleistocene climate oscillation on mangrove population dynamics could enrich our knowledge about the evolutionary history during times of historical climate change, which in turn may provide important information for their conservation. RESULTS: In this study, phylogeography of a mangrove tree Sonneratia alba was studied by sequencing three chloroplast fragments and seven nuclear genes. A low level of genetic diversity at the population level was detected across its range, especially at the range margins, which was mainly attributed to the steep sea-level drop and associated climate fluctuations during the Pleistocene glacial periods...
January 18, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28100025/sex-biased-transcriptome-divergence-along-a-latitudinal-gradient
#17
Scott L Allen, Russell Bonduriansky, Carla Sgro, Stephen F Chenoweth
Although not all sex-dependent gene expression is adaptive, it is likely an important genomic mechanism that allows each sex to independently adapt to environmental changes. Among Drosophila species, sex-biased genes display remarkably consistent evolutionary patterns; male-biased genes evolve faster than unbiased genes in both coding sequence and expression level, suggesting sex-differences in selection through time. However, comparatively little is known of the evolutionary process shaping sex-biased expression within species...
January 18, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28099948/mdm4-genetic-variants-and-risk-of-gastric-cancer-in-an-eastern-chinese-population
#18
Meng-Yun Wang, Ming Jia, Jing He, Fei Zhou, Li-Xin Qiu, Meng-Hong Sun, Ya-Jun Yang, Jiu-Cun Wang, Li Jin, Ya-Nong Wang, Qing-Yi Wei
MDM4 is a p53-interacting protein and plays an important role in carcinogenesis. In this study of 1,077 gastric cancer (GCa) cases and 1,173 matched cancer-free controls, we investigated associations between three tagging single nucleotide polymorphisms (SNPs) (rs11801299 G>A, rs1380576 C>G and rs10900598 G>T) in MDM4 and gastric cancer risk in an Eastern Chinese Population. In logistic regression analysis, a significantly decreased GCa risk was associated with the rs1380576 GG variant genotype (adjusted odds ratio [OR] =0...
January 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28099254/everolimus-in-pancreatic-neuroendocrine-carcinomas-g3
#19
Francesco Panzuto, Maria Rinzivillo, Francesca Spada, Lorenzo Antonuzzo, Toni Ibrahim, Davide Campana, Nicola Fazio, Gianfranco Delle Fave
OBJECTIVE: The aim of this study was to investigate everolimus efficacy in well-moderately differentiated pancreatic NEC (pNEC) G3. METHODS: This was a retrospective analysis of patients with pNEC G3 and Ki67 20% to 55% treated with everolimus. RESULTS: Fifteen patients with median Ki67 30% and Eastern Cooperative Oncology Group performance status 0 to 1 were evaluated. Of these, 4 patients received everolimus as first-line treatment, whereas 11 had been pretreated with chemotherapy or peptide receptor radionuclide therapy...
January 18, 2017: Pancreas
https://www.readbyqxmd.com/read/28099078/prevalence-of-terrapene-herpesvirus-1-in-free-ranging-eastern-box-turtles-terrapene-carolina-carolina-in-tennessee-and-illinois
#20
Lauren P Kane, Matthew C Allender, Grace Archer, Elena Dzhaman, John Pauley, A Russell Moore, Marilyn O Ruiz, Rebecca L Smith, John Byrd, Christopher A Phillips
Diseases affecting the upper respiratory tract, such as herpesviruses, are well described in captive chelonians worldwide, but their importance in free-ranging populations is less well known. To characterize the disease epidemiology of terrapene herpesvirus 1 (TerHV1), 409 free-ranging eastern box turtles ( Terrapene carolina carolina) in Tennessee and Illinois were tested for TerHV1 in 2013 and 2014 using TaqMan quantitative PCR. Whole blood and swabs of the oral mucosa were collected from 365 adults (154 females, 195 males, 16 unknown sex) and 44 juveniles...
January 18, 2017: Journal of Wildlife Diseases
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