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https://www.readbyqxmd.com/read/29218457/phenotypical-change-of-tumor-associated-macrophages-in-metastatic-lesions-of-clear-cell-renal-cell-carcinoma
#1
Takanobu Motoshima, Yuji Miura, Nanako Wakigami, Natsuki Kusada, Toshimi Takano, Naoko Inoshita, Toshikazu Okaneya, Yutaka Sugiyama, Tomomi Kamba, Motohiro Takeya, Yoshihiro Komohara
Macrophages are the main immune cells of the tumor microenvironment in clear cell renal cell carcinoma (ccRCC). A high density of CD163+ or CD204+ tumor-associated macrophages (TAMs), rather than the density of total TAMs, is known to be linked to poor clinical outcome. In the present study, we investigated the phenotypical differences between the paired primary and metastatic lesions in ccRCC cases. Using immunostaining, the densities of CD163+ and CD204+ TAMs in metastatic lesions were found to be significantly lower compared to primary lesions, although the total number of TAMs was increased in metastatic lesions...
December 7, 2017: Medical Molecular Morphology
https://www.readbyqxmd.com/read/29218250/evaluation-of-the-role-of-downregulation-of-snf5-ini1-core-subunit-of-swi-snf-complex-in-clear-cell-renal-cell-carcinoma-development
#2
Elzbieta Sarnowska, Michal Szymanski, Nataliia Rusetska, Marcin Ligaj, Iga Jancewicz, Pawel Cwiek, Marta Skrodzka, Marcin Leszczynski, Joanna Szarkowska, Alicja Chrzan, Malgorzata Stachowiak, Jaroslaw Steciuk, Anna Maassen, Lech Galek, Tomasz Demkow, Janusz A Siedlecki, Tomasz J Sarnowski
Clear cell renal cell carcinoma (ccRCC) is characterized by stabilization of hypoxia-inducible factor (HIF1), and mutations in von Hippel-Lindau (VHL) gene. Additionally, in about 40% of ccRCC cases the mutation in PBRM1 (POLYBROMO1) gene coding for a non-core subunit of SWI/SNF chromatin remodeling complex was found suggesting potential impairment of this complex function in ccRCC. In this study we assessed the extent to which the core SWI/SNF complex subunit - INI1 (hSNF5/SMARCB1) is affected in ccRCC and whether it has any consequences on the development of this type of cancer...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29215721/the-biological-roles-and-clinical-implications-of-micrornas-in-clear-cell-renal-cell-carcinoma
#3
REVIEW
Ying-Hua He, Chen Chen, Zheng Shi
Clear cell renal cell carcinoma (ccRCC) accounts for about 3% of tumors in adults as well as 85% of all primary renal carcinoma. And it is the third most predominant urological carcinoma, but it has the maximum mortality rate. Early diagnosis and proper follow-up of ccRCC patients may improve the prognosis of the illness. Thus, it is imperative to understand the new biomarkers of ccRCC and study new method for the modern therapy of this deadly disease. Furthermore, a large number of microRNAs (miRNAs), small non-coding RNAs, have been relevant to tumor type, stage, or survival and miRNAs might be progressed as the markers of diagnosis or prognosis in ccRCC...
December 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29215599/systematic-analysis-of-transcriptomic-profile-of-renal-cell-carcinoma-under-long-term-hypoxia-using-next-generation-sequencing-and-bioinformatics
#4
Szu-Chia Chen, Feng-Wei Chen, Ya-Ling Hsu, Po-Lin Kuo
Patients with clear cell renal cell carcinoma (ccRCC) are often diagnosed with both von Hippel-Lindau (VHL) mutations and the constitutive activation of hypoxia-inducible factor-dependent signaling. In this study, we investigated the effects of long-term hypoxia in 786-O, a VHL-defective renal cell carcinoma cell line, to identify potential genes and microRNAs associated with tumor malignancy. The transcriptomic profiles of 786-O under normoxia, short-term hypoxia and long-term hypoxia were analyzed using next-generation sequencing...
December 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29214011/long-non-coding-rna-h19-regulates-e2f1-expression-by-competitively-sponging-endogenous-mir-29a-3p-in-clear-cell-renal-cell-carcinoma
#5
Haowei He, Nana Wang, Xiaoming Yi, Chaopeng Tang, Dong Wang
Background: Numerous recent studies indicate that the long non-coding RNAs (lncRNAs) are frequently abnormal expressed and take critical roles in many cancers. Renal cell carcinoma is the secondary malignant tumors in the urinary system and has high mortality and morbidity. Around 80% of RCCs is clear cell renal cell carcinoma (ccRCC) and is characterized by high metastasis and relapse rate. However, the clinical significances of lncRNAs in ccRCC are still unknown. Methods: The human cancer lncRNA PCR array (Yingbio) was performed to detect the differentially expressed lncRNAs in human ccRCC samples...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/29212269/low-neighbor-of-brca1-gene-expression-predicts-poor-clinical-outcome-and-resistance-of-sunitinib-in-clear-cell-renal-cell-carcinoma
#6
Wen Xiao, Zhiyong Xiong, Changfei Yuan, Lin Bao, Di Liu, Xiong Yang, Wencheng Li, Junwei Tong, Yan Qu, Lei Liu, Haibing Xiao, Hongmei Yang, Xiaoping Zhang, Ke Chen
Objective: To study the expression of Neighbor of Brca1 gene (NBR1) in clear cell renal cell carcinoma (ccRCC), renal cancer cells and the chemoresistance cells and to elucidate its clinical prognostic and chemoresistance value. Materials and Methods: We screened the NBR1 mRNA in ccRCC from The Cancer Genome Atlas (TCGA) database and examined expression levels of NBR1 mRNA in 48 cases of ccRCC tissues, renal cancer cell lines and chemoresistance cells by qRT-PCR...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29209141/co-expression-network-analysis-identified-fcer1g-in-association-with-progression-and-prognosis-in-human-clear-cell-renal-cell-carcinoma
#7
Liang Chen, Lushun Yuan, Yongzhi Wang, Gang Wang, Yuan Zhu, Rui Cao, Guofeng Qian, Conghua Xie, Xuefeng Liu, Yu Xiao, Xinghuan Wang
Clear cell renal cell carcinoma (ccRCC) is the most common solid lesion within kidney, and its prognostic is influenced by the progression covering a complex network of gene interactions. In current study, the microarray data GSE66272 containing ccRCC and adjacent normal tissues was analyzed to identify 4042 differentially expressed genes, on which weighted gene co-expression network analysis was performed. Then 12 co-expressed gene modules were identified. The highest association was found between blue module and pathological stage (r = -0...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29207627/orellanine-specifically-targets-renal-clear-cell-carcinoma
#8
Lisa Buvall, Heidi Hedman, Alina Khramova, Deman Najar, Lovisa Bergwall, Kerstin Ebefors, Carina Sihlbom, Sven Lundstam, Anders Herrmann, Hanna Wallentin, Emelie Roos, Ulf A Nilsson, Martin Johansson, Jan Törnell, Börje Haraldsson, Jenny Nyström
Renal cell carcinoma (RCC), arising from the proximal tubule in the kidney, accounts for approximately 85% of kidney cancers and causes over 140,000 annual deaths worldwide. In the last decade, several new therapies have been identified for treatment of metastatic RCC. Although these therapies increase survival time compared to standard care, none of them has curative properties. The nephrotoxin orellanine specifically targets proximal tubular epithelial cells, leaving other organs unaffected. We therefore hypothesized that the selective toxicity of orellanine extends to clear cell RCC (ccRCC) cells since they emanate from proximal tubular cells...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29207195/a-novel-correlation-between-atp5a1-gene-expression-and-progression-of-human-clear-cell-renal-cell-carcinoma-identified-by-co%C3%A2-expression-analysis
#9
Lushun Yuan, Liang Chen, Kaiyu Qian, Gang Wang, Mengxin Lu, Guofeng Qian, Xinyue Cao, Wei Jiang, Yu Xiao, Xinghuan Wang
Clear cell renal cell carcinoma (ccRCC) is the most common solid lesion within kidneys, and its prognostic is influenced by the progression covering a complex network of gene interactions. In our study, a weighted gene co‑expression network was constructed to identify gene modules associated with the progression of ccRCC (n=35). In the significant module (R2 = -0.53), a total of 13 network hub genes were identified, and 2 of them were hub nodes in the protein-protein interaction network as well. In validation, ATP5A1 showed a higher correlation with the disease progression than any other hub gene in the hub module (P=0...
December 4, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29204790/cytoplasmic-expression-of-twist1-an-emt-related-transcription-factor-is-associated-with-higher-grades-renal-cell-carcinomas-and-worse-progression-free-survival-in-clear-cell-renal-cell-carcinoma
#10
Arezoo Rasti, Zahra Madjd, Maryam Abolhasani, Mitra Mehrazma, Leila Janani, Leili Saeednejad Zanjani, Mojgan Asgari
Twist1 is a key transcription factor, which confers tumor cells with cancer stem cell (CSC)-like characteristics and enhances epithelial-mesenchymal transition in pathological conditions including tumor malignancy and metastasis. This study aimed to evaluate the expression patterns and clinical significance of Twist1 in renal cell carcinoma (RCC). The cytoplasmic and nuclear expression of Twist1 were examined in 252 well-defined renal tumor tissues, including 173 (68.7%) clear cell renal cell carcinomas (ccRCC), 45 (17...
December 4, 2017: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/29202733/expression-of-micro-rnas-and-genes-related-to-angiogenesis-in-ccrcc-and-associations-with-tumor-characteristics
#11
Rita de Cássia Oliveira, Renato Fidelis Ivanovic, Katia Ramos Moreira Leite, Nayara Izabel Viana, Ruan César Aparecido Pimenta, José Pontes Junior, Vanessa Ribeiro Guimarães, Denis Reis Morais, Daniel Kanda Abe, Adriano João Nesrallah, Miguel Srougi, William Nahas, Sabrina Thalita Reis
BACKGROUND: Clear cell renal cell carcinoma (ccRCC) is the third most common urological cancer in adults. Our aim is to evaluate genes and miRNAs expression profiles involved with angiogenesis and tumor characteristics in ccRCC. METHODS: The expression levels of miRNAs miR-99a, 99b, 100; 199a; 106a; 106b; 29a; 29b; 29c; 126; 200a, 200b and their respective target genes: mTOR, HIF1-α, VHL, PDGF, VEGF, VEGFR1 and VEGFR2 were analyzed using qRT-PCR in tumor tissue samples from 56 patients with ccRCC...
December 4, 2017: BMC Urology
https://www.readbyqxmd.com/read/29198944/the-study-of-clear-cell-renal-cell-carcinoma-with-mr-diffusion-kurtosis-tensor-imaging-and-its-histopathologic-correlation
#12
Guangyu Wu, Zizhou Zhao, Qiuying Yao, Wen Kong, Jianrong Xu, Jin Zhang, Guiqin Liu, Yongming Dai
RATIONALE AND OBJECTIVES: The objective of this study was to compare the performance of diffusion kurtosis tensor imaging and diffusion-weighted imaging in the characterization of clear cell renal cell carcinoma (ccRCC) and their correlations with tumor histopathology. MATERIALS AND METHODS: Ninety-one patients diagnosed with ccRCC who underwent diffusion kurtosis tensor imaging were included in this study. Fractional anisotropy, mean diffusivity, radial diffusivity, axial diffusivity, mean kurtosis (MK), radial kurtosis (Krad), and axial kurtosis (Kax) data were produced...
November 29, 2017: Academic Radiology
https://www.readbyqxmd.com/read/29198924/sinomenine-hydrochloride-attenuates-the-proliferation-migration-invasiveness-angiogenesis-and-epithelial-mesenchymal-transition-of-clear-cell-renal-cell-carcinoma-cells-via-targeting-smad-in-vitro
#13
Bin Zhao, Lei Liu, Jun Mao, Kun Liu, Weiwang Fan, Jiheng Liu, Zhiwei Zhang, Quanlin Li
New strategies for the treatment of clear-cell renal cell carcinoma (ccRCC) are urgently needed. Recently, accumulating evidence has demonstrated that sinomenine hydrochloride (SH), extracted from the plant sinomenium acutum, has potent anti-cancer activity in multiple human malignant solid tumors. However, the underlying molecular mechanism by which SH treatment exerts its antagonizing tumorigenic effects has not been clearly elucidated. In this study, we showed that SH treatment exerted profound effects on cell growth in ccRCC in a dose- and time-dependent manner in vitro...
November 29, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29194709/low-grade-spindle-cell-proliferation-in-clear-cell-renal-cell-carcinoma-is-unlikely-to-be-an-initial-step-in-sarcomatoid-differentiation
#14
Ozlem Tanas Isikci, Huying He, Petr Grossmann, Reza Alaghehbandan, Monika Ulamec, Kvetoslava Michalova, Kristyna Pivovarcikova, Delia Perez Montiel, Ondrej Ondic, Ondrej Daum, Kristyna Prochazkova, Milan Hora, Michal Michal, Ondrej Hes
Spindle cell proliferation within clear cell renal cell carcinoma (ccRCC) is usually considered as sarcomatoid differentiation. Low-grade spindle cell proliferation (LG-SCP) in ccRCC was first described in 2001. This phenomenon is not common and can pose diagnostic challenges particularly in core biopsies. The aim of this study was to describe morphologic, immunohistochemical and molecular characteristics of ccRCCs with LG-SCP. 11 cases of ccRCC with LG-SCP were retrieved from approximately 21,000 renal tumors in our registry...
December 1, 2017: Histopathology
https://www.readbyqxmd.com/read/29192325/downregulation-of-microrna-1274a-induces-cell-apoptosis-through-regulation-of-bmpr1b-in-clear-cell-renal-cell-carcinoma
#15
Hirofumi Yoshino, Tomokazu Yonezawa, Masaya Yonemori, Kazutaka Miyamoto, Takashi Sakaguchi, Satoru Sugita, Youichi Osako, Shuichi Tatarano, Masayuki Nakagawa, Hideki Enokida
Our previous studies of the microRNA (miRNA) expression signature in clear cell renal cell carcinoma (ccRCC) indicated that miRNA-1274a (miR-1274a) was significantly upregulated in clinical specimens, suggesting that miR-1274a may act as an oncogenic miRNA in ccRCC. The aim of this study was to investigate the functional roles of miR-1274a and identify downstream tumor-suppressive targets regulated by miR‑1274a in ccRCC cells. Functional studies of miR-1274a were carried out by anti-miRNA to investigate cell proliferation and apoptosis using the A498, ACHN and Caki1 ccRCC cell lines...
January 2018: Oncology Reports
https://www.readbyqxmd.com/read/29187877/overexpression-of-ckap4-is-associated-with-poor-prognosis-in-clear-cell-renal-cell-carcinoma-and-functions-via-cyclin-b-signaling
#16
Chen-Min Sun, Jiang Geng, Yang Yan, Xudong Yao, Min Liu
Aim: We aimed to study the role of CKAP4 in clear cell renal cell carcinoma (ccRCC), which is not reported previously. Method: In silico exploration and validation using immunohistochemistry in ccRCC samples were used to identify the impact of CKAP4 expression on clinicopathological parameters. In vitro and in vivo studies were carried out to recapitulate the role of CKAP4 in ccRCC cell lines and animal models. Results: Overexpression of CKAP4 occurred in 5% of ccRCC patients, who had significantly worsened prognosis...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29183723/srebp1-driven-lipid-desaturation-supports-clear-cell-renal-cell-carcinoma-growth-through-regulation-of-nf-%C3%AE%C2%BAb-signaling
#17
Hao Yang, Xiao Zhang, Fang Liu, Jirong Fan, Bolin Wang, Chuanjiang Dong
Clear cell renal cell carcinoma (ccRCC), the most common type of kidney cancers, is an incurable and lethal disease. Although great progresses have been made in understanding the mechanism of ccRCC, metabolic reprogramming in ccRCC remains largely unclear. Here, we showed that lipid desatutation might be a metabolic hallmark of ccRCC. We demonstrated sterol regulatory element-binding protein 1 (SREBP1) is overexpressed in ccRCC cell lines and positively correlated with NF-κB activation. Further, SREBP1 is required for lipid desaturation and cell growth in ccRCC...
November 25, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29180874/expression-and-significance-of-b7-h3-and-tie-2-in-the-tumor-vasculature-of-clear-cell-renal-carcinoma
#18
Xianyun Zhang, Jindong Ji, Guangbo Zhang, Chuntao Fang, Fujin Jiang, Song Ma, Jianquan Hou
Tumor angiogenesis is required for tumor growth and metastasis, and the Ang/Tie-2 axis plays a pivotal role in angiogenesis. B7-H3, a new member of the B7 family of costimulatory molecules, has a critical function in the T-cell-mediated antitumor immune response, and abnormal tumor B7-H3 expression is frequently associated with a poor prognosis. However, the relationship between B7-H3 and angiogenesis in clear cell renal carcinoma (ccRCC) remains unclear. In this study, we used immunohistochemical methods to detect tumor vascular expression of B7-H3 and Tie-2 in tissue microarrays of 82 ccRCC patient samples...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29180334/-quantitative-and-comparative-proteomics-analysis-in-clear-cell-renal-cell-carcinoma-and-adjacent-noncancerous-tissues-by-2-d-dige
#19
Zhuang-Fei Chen, Yao-Jun Xiao, Ze-Hai Huang, Tong Chen, Shan-Chao Zhao, Yao-Dong Jiang, Peng Wu, Shao-Bin Zheng
OBJECTIVE: To identify specific protein markers for renal cell carcinoma detection and diagnosis, as well as develop new potential therapeutic targets of the disease. METHODS: We used two-dimensional difference in-gel electrophoresis (2-D DIGE) technique conjunction with mass spectrometry (MS) for the identification of significant differentially expressed proteins between 15cases of paired clear cell renal cell carcinoma (ccRCC) and adjacent normal renal tissues...
November 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/29179496/prognostic-role-of-myoferlin-expression-in-patients-with-clear-cell-renal-cell-carcinoma
#20
Dae Hyun Song, Gyung Hyuck Ko, Jeong Hee Lee, Jong Sil Lee, Jung Wook Yang, Min Hye Kim, Hyo Jung An, Myoung Hee Kang, Kyung Nyeo Jeon, Dong Chul Kim
Objectives: In patients with cancer, myoferlin protein hyperexpression has been correlated with poor patient prognosis. Here, we evaluated myoferlin expression in patients with clear cell renal cell carcinoma (ccRCC) and investigated the prognostic significance of myoferlin expression in these patients. Materials and Methods: One hundred and fifty-two patients with ccRCC who underwent treatment at Gyeongsang National University Hospital, Korea, between January 2000 and December 2009 were enrolled...
October 24, 2017: Oncotarget
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