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Angioedema

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https://www.readbyqxmd.com/read/28928989/an-unusual-case-of-recurrent-hypersensitivity-reaction-associated-with-kounis-like-acute-coronary-syndrome
#1
Shanker Kundumadam, Vivek Reddy, Sagar Mallikethi Reddy, Pradeep Kathi, Aiden Abidov
There have been multiple reports of allergic reactions associated with acute coronary syndromes. This has been classically described as Kounis syndrome. We present an unusual case of 70-year-old male with multiple prior hypersensitivity reactions and history of coronary artery bypass grafting who presented recurrent episode of severe angioedema and anaphylaxis. He responded to epinephrine but subsequently developed a non-ST elevation myocardial infarction with worsening heart failure. Our case is unique in that, unlike classic Kounis syndrome, the acute coronary event in this case did not present concurrently with the allergic reaction; rather it took nearly 48 hours to present...
2017: Case Reports in Cardiology
https://www.readbyqxmd.com/read/28905884/clinical-utility-gene-card-for-hereditary-angioedema-with-normal-c1-inhibitor-haenc1
#2
Christiane Stieber, Sven Cichon, Markus Magerl, Markus M Nöthen
No abstract text is available yet for this article.
October 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28903805/recombinant-human-c1-esterase-inhibitor-for-acute-hereditary-angioedema-attacks-with-upper-airway-involvement
#3
M A M A Riedl, H H Li, M M Cicardi, J R J R Harper, A A Relan
BACKGROUND: Recombinant human C1 esterase inhibitor (rhC1-INH) is approved for treatment of hereditary angioedema (HAE)in adolescents and adults. HAE attacks that involve the upper airway can be life threatening, and data on the administration of rhC1-INH for these types of attacks are currently limited. OBJECTIVE: To evaluate the efficacy and safety of rhC1-INH for treatment of acute HAE attacks with upper airway involvement. METHODS: A pooled analysis of data from three clinical trials with open-label extensions examined rhC1-INH for treatmentof acute HAE attacks with upper airway involvement...
September 13, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28888847/hereditary-angioedema-in-2-sisters-due-to-paternal-gonadal-mosaicism
#4
Didier G Ebo, Athina L Van Gasse, Vito Sabato, Esther Bartholomeus, Edwin Reyniers, Jean-François Vanbellinghen, Hélène A Poirel, Geert Mortier
No abstract text is available yet for this article.
September 6, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28885312/angioedema-stomatitis-and-urticaria-caused-by-contact-allergy-to-invisalign
#5
Olabola Awosika, Stephanie Kao, Monica Rengifo-Pardo, Alison Ehrlich
No abstract text is available yet for this article.
September 2017: Dermatitis
https://www.readbyqxmd.com/read/28874235/efficacy-of-recombinant-human-c1-esterase-inhibitor-for-the-treatment-of-severe-hereditary-angioedema-attacks
#6
H H Li, A Reshef, J W Baker, J R Harper, A Relan
BACKGROUND: Severe attacks of hereditary angioedema (HAE) are debilitating and potentially life threatening, and can increase anxiety and the use of medical resources. OBJECTIVE: This post hoc assessment evaluated recombinant human C1 esterase inhibitor (rhC1-INH) used to treat acute severe HAE attacks. METHODS: In a double-blind, randomized-controlled trial (RCT), patients with an HAE attack (baseline visual analog scalescore of greater than or equal to 50 mm, with severe attacks defined as greater than or equal to 75 mm) were randomly assigned to receive rhC1-INH (50 IU/kg for patients who weighed <84 kg; 4200 IU for patients who weighed more than or equal to 84 kg) or placebo...
September 5, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28861213/idiopathic-non-histaminergic-acquired-angioedema-a-case-series-and-discussion-of-published-clinical-trials
#7
Martin Christian Bucher, Tatjana Petkovic, Arthur Helbling, Urs Christian Steiner
BACKGROUND: Idiopathic non-histaminergic acquired angioedema (InH-AAE) is a rare disease for which there are no available laboratory parameters to clearly define the disorder. Therapy is often difficult and various treatment options have been proposed. In this paper, we have evaluated the most effective therapies for InH-AAE on the basis of current literature and report the therapeutic effect of omalizumab in three patients with InH-AAE. METHODS: Literature was searched with a combination of MeSH/EMTREE terms and freetext search for angioedema and therapy/omalizumab in the databases Medline (Ovid), PubMed/Premedline, Embase, Cochrane library and Scopus with no time or language restrictions...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28856389/structural-and-metabolic-changes-in-the-traumatically-injured-rat-brain-high-resolution-in-vivo-proton-magnetic-resonance-spectroscopy-at-7%C3%A2-t
#8
Jing Li, Can Zhao, Jia-Sheng Rao, Fei-Xiang Yang, Zhan-Jing Wang, Jian-Feng Lei, Zhao-Yang Yang, Xiao-Guang Li
PURPOSE: The understanding of microstructural and metabolic changes in the post-traumatic brain injury is the key to brain damage suppression and repair in clinics. METHODS: Ten female Wistar rats were traumatically injured in the brain CA1 region and above the cortex. Next, diffusion tensor magnetic resonance imaging (DTI) and proton magnetic resonance spectroscopy ((1)H MRS) were used to analyze the microstructural and metabolic changes in the brain within the following 2 weeks...
August 31, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28855002/health-related-quality-of-life-in-relation-to-disease-activity-in-adults-with-hereditary-angioedema-in-sweden
#9
undefinedP Nordenfelt, undefinedM Nilsson, undefinedA Lindfors, undefinedC-F Wahlgren, undefinedJ Bjorkander
BACKGROUND: Health-related quality of life (HR-QoL) is impaired in patients with hereditary angioedema (HAE) but has notyet been satisfactorily described. OBJECTIVE: To study HR-QoL in patients with HAE by combining different HR-QoL instruments with disease activity assessment. METHODS: All adults in the Swedish HAE registry were invited to take part in this questionnaire study, which used the generic HR-QoL instruments, EuroQol 5 Dimensions 5 Level (EQ-5D-5L) and the RAND Corporation Short Form 36 (RAND-36), the disease-specific Angioedema Quality of Life instrument (AE-QoL), the recently introduced Angioedema Activity Score (AAS) form, and questionnaires on sick leave and prophylactic medication...
August 30, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28825570/treatment-of-hereditary-angioedema-due-to-c1-inhibitor-deficiency-in-argentina
#10
Eloisa Malbrán, Alejandra Menéndez, Alejandro Malbrán
The benefits of the worldwide approval of new drugs for the treatment of acute C1-INH-HAE attacks may still not reach all patients. Identifying the current barriers in the access to medication, as well as conducting a detailed assessment of the progress in this area, is essential to achieve universal treatment. Two hundred and twenty five patients registered in the Argentina Hereditary Angioedema Patient Association (AHAEPA) were randomly selected and invited to participate in a web based questionnaire on accessibility to icatibant and pdC1-INH, self-treatment, delay to treatment, and coverage...
2017: Medicina
https://www.readbyqxmd.com/read/28818177/angioedema
#11
Janina Hahn, Thomas K Hoffmann, Bastian Bock, Melanie Nordmann-Kleiner, Susanne Trainotti, Jens Greve
BACKGROUND: Acute angioedema of the upper airways can be life-threatening. An important distinction is drawn between mast-cell-mediated angioedema and bradykinin-mediated angioedema; the treatment of these two entities is fundamentally different. METHODS: This review is based on pertinent articles retrieved by a selective search in PubMed and on guidelines concerning the treatment of angioedema. The authors draw on their own clinical experience in their assessment of the literature...
July 24, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28800865/anaphylaxis
#12
REVIEW
Daniel LoVerde, Onyinye I Iweala, Ariana Eginli, Guha Krishnaswamy
Anaphylaxis is a systemic, life-threatening disorder triggered by mediators released by mast cells and basophils activated via allergic (IgE-mediated) or nonallergic (non-IgE-mediated) mechanisms. It is a rapidly evolving, multisystem process involving the integumentary, pulmonary, gastrointestinal, and cardiovascular systems. Anaphylaxis and angioedema are serious disorders that can lead to fatal airway obstruction and culminate in cardiorespiratory arrest, resulting in hypoxemia and/or shock. Often, these disorders can be appropriately managed in an outpatient setting; however, these conditions can be severe enough to warrant evaluation of the patient in the ED and in some cases, hospitalization, and management in an ICU...
August 8, 2017: Chest
https://www.readbyqxmd.com/read/28798744/the-mast-cell-contact-and-coagulation-system-connection-in-anaphylaxis
#13
REVIEW
Mar Guilarte, Anna Sala-Cunill, Olga Luengo, Moisés Labrador-Horrillo, Victoria Cardona
Anaphylaxis is the most severe form of allergic reaction, resulting from the effect of mediators and chemotactic substances released by activated cells. Mast cells and basophils are considered key players in IgE-mediated human anaphylaxis. Beyond IgE-mediated activation of mast cells/basophils, further mechanisms are involved in the occurrence of anaphylaxis. New insights into the potential relevance of pathways other than mast cell and basophil degranulation have been unraveled, such as the activation of the contact and the coagulation systems...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28795768/hereditary-angioedema-with-a-mutation-in-the-plasminogen-gene
#14
K Bork, K Wulff, L Steinmüller-Magin, I Braenne, P Staubach-Renz, G Witzke, J Hardt
BACKGROUND: Hereditary angioedema (HAE) with normal C1-INH (HAEnCI) may be linked to specific mutations in the coagulation factor 12 (FXII) gene (HAE-FXII) or functional mutations in other genes that are still unknown. We sought to identify and characterize a hitherto unknown type of HAE with normal C1-INH and without mutation in the F12 gene. METHODS: The study comprised analysis of whole exome sequencing, Sanger sequencing, and clinical data of patients. RESULTS: We detected a mutation in the plasminogen gene in patients with HAEnCI...
August 10, 2017: Allergy
https://www.readbyqxmd.com/read/28791569/pediatric-angioedema
#15
REVIEW
Debendra Pattanaik, Jay Adam Lieberman
PURPOSE OF REVIEW: The aims of this study are to update the clinician on current understanding of angioedema as it presents in the pediatric population and to review proper diagnostic techniques and treatment modalities for various types of angioedema. RECENT FINDINGS: Angioedema is still best classified by whether it is likely histaminergic or kinin-mediated. New guidelines have been published around the world to help diagnose and treat both forms (urticaria/angioedema and hereditary angioedema)...
August 8, 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28782632/cleaved-kininogen-as-a-biomarker-for-bradykinin-release-in-hereditary-angioedema
#16
Zonne L M Hofman, Steven de Maat, Chiara Suffritti, Andrea Zanichelli, Cassandra van Doorn, Silvie A E Sebastian, Nora Veszeli, Dorottya Csuka, Thomas Renné, Gerard Pasterkamp, Marco Cicardi, Henriette Farkas, C Erik Hack, Coen Maas
No abstract text is available yet for this article.
August 4, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28781749/pediatric-hereditary-angioedema-an-update
#17
REVIEW
Geetika Sabharwal, Timothy Craig
Hereditary angioedema (HAE) with C1-inhibitor (C1-Inh) deficiency (C1-Inh-HAE) is a rare, life-threatening, and disabling genetic disorder characterized by self-limited tissue swelling caused by deficiency or dysfunction of C1-Inh. Our aim in this update is to discuss new advances in HAE therapy, focusing mainly on the various treatment options that have become available recently and also drugs that are under trial for prophylaxis to prevent attacks. There is a paradigm shift to where the treatment of HAE is headed, focusing now on prophylactic treatment rather than abortive management...
2017: F1000Research
https://www.readbyqxmd.com/read/28780879/-effect-of-danazol-treatment-on-growth-in-pediatric-patients-with-hereditary-angioedema-due-to-c1-inhibitor-deficiency
#18
Kinga Viktória Kőhalmi, Nóra Veszeli, Andrea Luczay, Lilian Varga, Henriette Farkas
INTRODUCTION: Attenuated androgens are used for the prevention of angioedema attacks of hereditary angioedema with C1-inhibitor deficiency. After prepuberty, their use can lead to growth retardation. AIM: We assessed the effect of danazol on the growth of pediatric patients with hereditary angioedema. METHOD: In the retrospective study on 42 patients diagnosed with hereditary angioedema, we calculated the deviation from the mid-parental target height, and analyzed it against the gender, the dose and duration of danazol treatment administered before the age of 21 years and before the age of 16 years...
August 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28780207/hereditary-angioedema-an-overlooked-cause-of-recurrent-abdominal-pain-and-free-peritoneal-fluid
#19
Piotr Eder, Maciej Adler, Liliana Lykowska-Szuber
No abstract text is available yet for this article.
August 2, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28772029/ace-inhibitor-associated-intestinal-angioedema-in-orthotopic-heart-transplantation
#20
Dushyanth Srinivasan, Garth W Strohbehn, Thomas Cascino
Angiotensin-converting enzyme inhibitor induced angioedema commonly involves the head and neck area. We report a case of angiotensin-converting enzyme inhibitor induced intestinal angioedema in a heart transplant recipient on mTOR immunosuppression. A 36-year-old Caucasian woman with history of heart transplantation on sirolimus, tacrolimus and prednisone presented to the Emergency Department with abdominal pain, one day following lisinopril initiation. A computer tomography scan demonstrated diffuse bowel wall thickening consistent with pancolitis and edema...
August 2017: ESC Heart Failure
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