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Angioedema

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https://www.readbyqxmd.com/read/29776559/angioedema-in-heart-failure-patients-treated-with-sacubitril-valsartan-lcz696-or-enalapril-in-the-paradigm-hf-study
#1
Victor Shi, Michele Senni, Hendrik Streefkerk, Vikas Modgill, Wenchun Zhou, Allen Kaplan
BACKGROUND: PARADIGM-HF demonstrated significant clinical benefits for sacubitril/valsartan (LCZ696, an angiotensin receptor neprilysin inhibitor) versus the angiotensin-converting enzyme inhibitor (ACEI) enalapril in patients with heart failure with reduced ejection fraction. As inhibition of ACE, and co-inhibition of ACE and neprilysin, may increase the risk of angioedema, this was an adverse event of special interest. METHODS: Following sequential enalapril and sacubitril/valsartan run-ins, patients were randomized to twice-daily sacubitril/valsartan 200 mg or enalapril 10 mg...
August 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29772036/chronic-urticaria-following-practice-guidelines
#2
E P Westby, C Lynde, G Sussman
Histamine is a key inflammatory player in the pathogenesis of urticaria, a mast-cell-driven disease characterized clinically by the development of wheals, angioedema, or both. Changes to the management of chronic spontaneous urticaria have recently been adopted due to increasing literature surrounding the efficacy and safety of up-dosing modern second-generation H1 -antihistamines and the use of omalizamub, a biologic agent, as a third-line treatment. Given the prevalence of chronic urticaria and its impact on quality of life, this editorial aims to provide a summary of the proposed updated guidelines for the management of chronic urticaria as agreed upon at the 5th Consensus Conference on the Update and Revision of the EAACI/GA2 LEN/EDF/WAO Guideline for Urticaria in Berlin in December 2016...
May 2018: Skin Therapy Letter
https://www.readbyqxmd.com/read/29757016/icatibant-for-the-treatment-of-hereditary-angioedema-with-c1-inhibitor-deficiency-in-adolescents-and-in-children-aged-over-2-years
#3
Henriette Farkas, Kinga Viktória Kőhalmi
Hereditary angioedema (HAE) due to C1-inhibitor deficiency (C1-INH-HAE) is a rare disorder with life-threatening complications if untreated. It begins during childhood, and reduces the patient's quality of life. Therefore, the availability of an easily administered agent to relieve unpredictable HAE episodes is indispensable for this age group. Areas covered: Randomized, double-blind, placebo-controlled, open-label extensions and prospective observational studies have proven the safety and efficacy of the subcutaneously administered bradykinin B2 receptor antagonist, icatibant, in the acute treatment of HAE episodes in adult C1-INH-HAE patients...
May 14, 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29753808/targeted-next-generation-sequencing-for-the-molecular-diagnosis-of-hereditary-angioedema-due-to-c1-inhibitor-deficiency
#4
Gedeon Loules, Maria Zamanakou, Faidra Parsopoulou, Sofia Vatsiou, Fotis Psarros, Dorottya Csuka, Grzegorz Porebski, Krystyna Obtulowicz, Anna Valerieva, Maria Staevska, Alberto López-Lera, Margarita López-Trascasa, Dumitru Moldovan, Markus Magerl, Marcus Maurer, Matthaios Speletas, Henriette Farkas, Anastasios E Germenis
SERPING1 genotyping of subjects suspicious for hereditary angioedema due to C1-INH deficiency (C1-INH-HAE) is important for clinical practice as well as for research reasons. Conventional approaches towards the detection of C1-INH-HAE-associated SERPING1 variants are cumbersome and time-demanding with many pitfalls. To take advantage of the benefits of next-generation sequencing (NGS) technology, we developed and validated a custom NGS platform that, by targeting the entire SERPING1 gene, facilitates genetic testing of C1-INH-HAE patients in clinical practice...
May 10, 2018: Gene
https://www.readbyqxmd.com/read/29742892/epidemiology-of-urticaria-including-physical-urticaria-and-angioedema-in-korea
#5
Jeong-Hun Seo, Jae-Woo Kwon
Background/Aims: Despite the high burden and frequency of urticaria, its epidemiology is not well known. We investigated the epidemiology of various type of urticaria in Korea and changes in its annual prevalence over 5 years. Methods: We used data from the 2010 to 2014 Health Insurance Review and Assessment database, which covers the claims of 97.0% of the South Korean population. Patients aged > 10 years old were included in this study. The presence of urticaria was identified on physician-certified diagnoses using the International Classification of Diseases 10th Revision (ICD-10) codes that include various type of urticaria (L500-L509) and angioedema (T783)...
May 11, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29737365/-anaphylactic-reaction-to-camomile-tea
#6
S Wahl, P-G Sator
The case of a man with type I allergy after the intake of camomile tea is presented. About 30 min after consumption he was hospitalised with palmar pruritus, swelling of the eyelids, upper lip and nasal mucosa as well as narrowness of the throat. Hereditary angioedema was excluded. The skin prick test confirmed the diagnosis of a type I allergy due to camomile tea.
May 8, 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29735174/-tranexamic-acid-as-first-line-emergency-treatment-for-episodes-of-bradykinin-mediated-angioedema-induced-by-ace-inhibitors
#7
C Beauchêne, J Martins-Héricher, D Denis, L Martin, H Maillard
INTRODUCTION: Episodes of acquired bradykinin-mediated angioedema due to angiotensin-converting enzyme (ACE) inhibitors may result in fatal outcomes. There is no consensus regarding emergency pharmacological management of these episodes. Treatment options include icatibant and C1INH concentrate. Tranexamic acid is administered for moderate episodes. Its efficacy in the treatment of ACE inhibitor-induced episodes of angioedema is not established. The aim of this retrospective study is to assess the benefits of emergency tranexamic acid administration in the management of ACE inhibitor-induced episodes of angioedema...
May 4, 2018: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29733981/montelukast-reduces-symptom-severity-and-frequency-in-patients-with-angioedema-predominant-chronic-spontaneous-urticaria
#8
Ayobami T Akenroye, Conor McEwan, Sarbjit S Saini
No abstract text is available yet for this article.
May 4, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29732294/shellfish-crustacean-oral-allergy-syndrome-among-national-service-pre-enlistees-in-singapore
#9
Bernard Yu-Hor Thong, Shalini Arulanandam, Sze-Chin Tan, Teck-Choon Tan, Grace Yin-Lai Chan, Justina Wei-Lyn Tan, Mark Chong-Wei Yeow, Chwee-Ying Tang, Jinfeng Hou, Khai-Pang Leong
Background: All Singaporean males undergo medical screening prior to compulsory military service. A history of possible food allergy may require referral to a specialist Allergy clinic to ensure that special dietary needs can be taken into account during field training and deployment. Objective: To study the pattern of food allergy among pre-enlistees who were referred to a specialist allergy clinic to work up suspected food allergy. Methods: Retrospective study of all pre-enlistees registered in the Clinical Immunology/Allergy New Case Registry referred to the Allergy Clinic from 1 August 2015 to 31 May 2016 for suspected food allergy...
April 2018: Asia Pacific Allergy
https://www.readbyqxmd.com/read/29730014/angioedema-systemic-activation-process-during-prodromes
#10
Samuel Luyasu, Delphine Charignon, Denise Ponard, Christian Drouet, Arije Ghannam
No abstract text is available yet for this article.
May 3, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29729940/a-transcriptomic-study-of-hereditary-angioedema-attacks
#11
Giuseppe Castellano, Chiara Divella, Fabio Sallustio, Vincenzo Montinaro, Claudia Curci, Andrea Zanichelli, Erika Bonanni, Chiara Suffritti, Sonia Caccia, Fleur Bossi, Anna Gallone, Francesco Paolo Schena, Loreto Gesualdo, Marco Cicardi
BACKGROUND: Hereditary Angioedema (HAE) due to C1-inhibitor deficiency is a lifelong illness characterized by recurrent acute attacks of localized skin or mucosal edema. An activation of the kallikrein/bradykinin pathway at endothelial cell level has a relevant pathogenetic role in acute HAE attacks. Moreover, other pathways are involved, given the variable clinical expression of the disease in different patients. OBJECTIVE: To explore the involvement of other putative genes in the edema formation...
May 3, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29729442/recurrent-retroperitoneal-angioedema
#12
Maddalena Alessandra Wu, Sonia Ippolito, Andrea Zanichelli, Francesca Perego, Marco Cicardi
No abstract text is available yet for this article.
May 2, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29729138/quantification-of-human-complement-c2-protein-using-an-automated-turbidimetric-immunoassay
#13
Clare Elizabeth Tange, Bridget Johnson-Brett, Alex Cook, Patrick Stordeur, Fabian Brohet, Stephen Jolles, Rachel Steven, Mark Ponsford, Andrew Roberts, Tariq El-Shanawany, Stephen Harding, Gregg Wallis, Antony Richard Parker
BACKGROUND: The measurement of complement components is clinically useful where a deficiency is suspected, or where excessive activation and consumption are present in disease. C2 deficiency carries an increased risk of developing systemic lupus erythematosus, recurrent infections and atherosclerosis. In this study, we have evaluated The Binding Site's Human Complement C2 SPAPLUS® assay. METHODS: Linearity was tested using 13 sample dilutions covering the standard measuring range...
May 5, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29729103/effectiveness-of-omalizumab-in-chronic-spontaneous-urticaria-assessed-with-patient-reported-outcomes-a-prospective-study
#14
Misbah Noshela Ghazanfar, Jesper Grønlund Holm, Simon Francis Thomsen
AIM: To examine the effectiveness of omalizumab (anti-IgE) on symptoms and disease-related quality of life in chronic spontaneous urticaria (CSU), and to identify possible patient specific factors associated with response to omalizumab in patients with antihistamine refractory CSU. METHODS: Six months prospective trial of omalizumab 300 mg every four weeks among patients with CSU from a dermatological university department. The primary outcome was the urticaria activity score in the past week (UAS7) at three months...
May 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29728439/angioedema-of-the-small-bowel-caused-by-lisinopril
#15
Mark Terence P Mujer, Manoj P Rai, Divyesh Reddy Nemakayala, Julie L Yam
No abstract text is available yet for this article.
May 4, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29728119/epidemiology-of-bradykinin-mediated-angioedema-a-systematic-investigation-of-epidemiological-studies
#16
Emel Aygören-Pürsün, Markus Magerl, Andreas Maetzel, Marcus Maurer
BACKGROUND: Bradykinin-mediated angioedema (Bk-AE) can be life-threatening and requires specific targeted therapies. Knowledge of its epidemiology may help optimize its management. METHODS: We systematically searched the medical literature to identify abstracts of interest indexed between 1948 and March, 2016. We used published national survey data on the proportion of the population treated with angiotensin-converting enzyme inhibitors (ACEI) to derive estimates of the population prevalence of ACEI-AE in the USA, Germany and France...
May 4, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29723946/-plantago-psyllium-secondary-anaphylaxis-case-report
#17
Rodrigo Collado-Chagoya, Javier Hernández-Romero, Gumaro Alejandro Eliosa-Alvarado, Ana Carmen García-González, Rosa Isela Campos-Gutiérrez, Andrea Velasco-Medina, Guillermo Velázquez-Sámano
BACKGROUND: Psyllium is a derivative of Plantago ovata ground seed and husk that is used as bulk-forming laxatives owing to its hydrocolloid properties. CASE REPORT: 43-year-old female nurse with previous diagnosis of drug allergy and allergic rhinitis who, after the preparation and administration of a laxative, developed rhinoconjunctivitis symptoms, urticarial syndrome, angioedema and bronchospasm, which led to conclude that she had an anaphylactic reaction. She was treated with adrenaline, corticosteroids and antihistamines...
January 2018: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/29723945/-are-natural-analgesic-products-safe-in-patients-with-allergy-to-non-steroidal-anti-inflammatory-drugs
#18
Iván Chérrez-Ojeda, Juan Carlos Calderón, Erick Calero, César Terán, Annia Chérrez
BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAID)-induced hypersensitivity reactions can be clinically apparent with asthma, rhinosinusitis, anaphylaxis or rash. Although natural anti-inflammatory products can have similar components, they are not subjected to rigorous quality control standards. CASE REPORT: The case is presented of a 22-year-old female with NSAID allergy who attended with facial and laryngeal angioedema associated with pruritus in eyelids and pharynx...
January 2018: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/29723938/-prevalence-of-sensitization-and-allergy-to-kiwi-fruit-actinidia-deliciosa-in-adults-with-allergic-diseases
#19
Tonatiuh Ramses Bedolla-Pulido, Silvia Araceli Álvarez-Corona, Tonantzin Isis Bedolla-Pulido, Benjamín Uribe-Cota, Tania González-Mendoza, Martín Bedolla-Barajas
BACKGROUND: The kiwi fruit (Actinidia deliciosa) is a food that has been recognized for its allergenic capability for more than 30 years. In general, kiwi allergy is characterized by local discomfort, but systemic reactions such as rash, angioedema, rhinitis, conjunctivitis or anaphylaxis can be triggered. OBJECTIVE: To determine the prevalence of sensitization and allergy to kiwi in adults with allergic diseases. METHODS: By means of a cross-sectional, retrolective study, data corresponding to 370 patients aged ≥16 years were analyzed...
January 2018: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/29723372/suppression-of-wheal-and-flare-in-histamine-test-by-the-main-h1-antihistamines-commercialized-in-brazil
#20
Helena Maciel-Guerra, Mariana Álvares Penha, Marília Formentini Scotton Jorge, Ricardo da Silva Libório, Ana Cláudia Nazareno Dos Anjos Carrijo, Maria Rita Parise-Fortes, Hélio Amante Miot
BACKGROUND: Several dermatoses are mediated by histamine, such as urticaria, angioedema, and papular urticaria. There are no Brazilian studies comparing the potency of antihistamines. OBJECTIVES: To evaluate the tolerability and efficacy of the main commercial brand and generic H1 antihistamines, regarding the suppression of the wheal and flare to the histamine test. METHODS: A quasi-experimental, open study with 10 healthy adults submitted to the histamine test on the ventral aspect of the forearms...
March 2018: Anais Brasileiros de Dermatologia
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