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https://www.readbyqxmd.com/read/28748726/natural-products-for-human-health-an-historical-overview-of-the-drug-discovery-approaches
#1
S Bernardini, A Tiezzi, V Laghezza Masci, E Ovidi
Natural products (NPs) are secondary metabolites produced and used by organisms for defending or adapting purposes. These molecules were naturally selected during thousands of years to improve the specificity and cover a very wide range of functions, depending on the origin, the habitat and the specific activity carried out in the organism of origin. Due to these intrinsic features, NPs have been used as healing agents since thousands of years and still today continue to be the most important source of new potential therapeutic preparations...
July 27, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28747024/clinical-profile-and-outcomes-in-octogenarians-with-atrial-fibrillation-a-community-based-study-in-a-specific-european-health-care-area
#2
Moisés Rodríguez-Mañero, Estrella López-Pardo, Alberto Cordero, Omar Kredieh, María Pereira-Vazquez, Jose-Luis Martínez-Sande, Alvaro Martínez-Gomez, Carlos Peña-Gil, José Novo-Platas, Javier García-Seara, Pilar Mazón, Ricardo Laje, Isabel Moscoso, Alfonso Varela-Román, Jose María García-Acuña, José Ramón González-Juanatey
BACKGROUND: Age increases risk of stroke and bleeding. Clinical trial data have had relatively low proportions of elderly subjects. We sought to study a Spanish population of octogenarians with atrial fibrillation (AF) by combining different sources of electronic clinical records from an area where all medical centres utilized electronic health record systems. METHODS: Data was derived from the Galician Healthcare Service information system. RESULTS: From 383,000 subjects, AF was coded in 7990 (2...
September 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28745934/spinal-cord-injury-clinical-registries-improving-care-across-the-sci-care-continuum-by-identifying-knowledge-gaps
#3
Marcel F Dvorak, Christiana L Cheng, Nader Fallah, Argelio Santos, Derek Atkins, Suzanne Humphreys, Carly S Rivers, Barry A B White, Chester Ho, Henry Ahn, Brian K Kwon, Sean Christie, Vanessa K Noonan
Timely access and ongoing delivery of care and therapeutic interventions is needed to maximize recovery and function after traumatic spinal cord injury (tSCI). To ensure these decisions are evidence-based, access to consistent, reliable, and valid sources of clinical data is required. The Access to Care and Timing Model used data from the Rick Hansen SCI Registry (RHSCIR) to generate a simulation of healthcare delivery for persons after tSCI and to test scenarios aimed at improving outcomes and reducing the economic burden of SCI...
July 26, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28742870/factors-contributing-to-food-insecurity-among-women-living-with-hiv-in-the-dominican-republic-a-qualitative-study
#4
Kathryn P Derose, Denise D Payán, María Altagracia Fulcar, Sergio Terrero, Ramón Acevedo, Hugo Farías, Kartika Palar
BACKGROUND: Food insecurity contributes to poor health outcomes among people living with HIV. In Latin America and the Caribbean, structural factors such as poverty, stigma, and inequality disproportionately affect women and may fuel both the HIV epidemic and food insecurity. METHODS: We examined factors contributing to food insecurity among women living with HIV (WLHIV) in the Dominican Republic (DR). Data collection included in-depth, semi-structured interviews in 2013 with 30 WLHIV with indications of food insecurity who resided in urban or peri-urban areas and were recruited from local HIV clinics...
2017: PloS One
https://www.readbyqxmd.com/read/28739777/establishment-of-a-comprehensive-drug-overdose-fatality-surveillance-system-in-kentucky-to-inform-drug-overdose-prevention-policies-interventions-and-best-practices
#5
Sarah L Hargrove, Terry L Bunn, Svetla Slavova, Dana Quesinberry, Tracey Corey, William Ralston, Michael D Singleton, Van Ingram
BACKGROUND: According to the National Center for Health Statistics, Kentucky had the third highest drug overdose fatality rate in the nation in 2015 at 29.9 drug overdose fatalities per 100 000 population. OBJECTIVE: The elevated drug overdose fatality rate necessitated the development and implementation of a comprehensive multisource drug overdose fatality surveillance system (DOFSS). METHODS: DOFSS stakeholder work group members and data sources were identified, and memorandums of understanding were established...
July 24, 2017: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/28738890/an-examination-of-australian-newspaper-coverage-of-the-link-between-alcohol-and-cancer-2005-to-2013
#6
Jaklin Eliott, Andrew John Forster, Joshua McDonough, Kathryn Bowd, Shona Crabb
BACKGROUND: Alcohol is a Class-1 carcinogen but public awareness of the link between alcohol and cancer is low. The news media is a popular, readily-accessible source of health information and plays a key role in shaping public opinion and influencing policy-makers. Examination of how the link between alcohol and cancer is presented in Australian print media could inform public health advocacy efforts to raise awareness of this modifiable cancer risk factor. METHOD: This study provides a summative qualitative content analysis of 1502 articles that included information about a link between alcohol and cancer, as reported within Australian newspaper media (2005-2013)...
July 24, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28735983/factors-influencing-the-willingness-of-allied-health-students-to-donate-organs-or-tissues
#7
S H Elsafi, M M Al-Adwani, K M Al-Jubran, M M Abu Hassan, E M Al Zahrani
BACKGROUND: There has been an increase in the number of patients waiting for organ transplantation. METHODS: A questionnaire on knowledge and attitude toward organ donation was completed by 434 allied health students. RESULTS: Overall knowledge about the various aspects of organ donation was adequate and was higher among women and clinical students. Although the majority were willing to be living donors for their families, very few students supported deceased organ donation, and even fewer of them had thought about an organ donation card...
July 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28735905/awareness-and-knowledge-of-obstructive-sleep-apnea-among-the%C3%A2-general-population
#8
Ching-Hui Sia, Yueheng Hong, Linda W L Tan, Rob M van Dam, Chi-Hang Lee, Adeline Tan
BACKGROUND: Obstructive sleep apnea (OSA) is an increasingly prevalent condition that remains largely undiagnosed. We aimed to assess the level of awareness and knowledge of OSA among the general population. METHODS: The Singapore Health 2 was a population-based study that comprised interview and health screening components. Out of 2720 subjects who completed the interview component, 2080 subjects gave consent for further health surveys. We contacted these subjects and conducted a structured telephone interview...
August 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28735777/heroin-and-fentanyl-overdoses-in-kentucky-epidemiology-and-surveillance
#9
Svetla Slavova, Julia F Costich, Terry L Bunn, Huong Luu, Michael Singleton, Sarah L Hargrove, Jeremy S Triplett, Dana Quesinberry, William Ralston, Van Ingram
BACKGROUND: The study aims to describe recent changes in Kentucky's drug overdose trends related to increased heroin and fentanyl involvement, and to discuss future directions for improved drug overdose surveillance. METHODS: The study used multiple data sources (death certificates, postmortem toxicology results, emergency department [ED] records, law enforcement drug submissions, and prescription drug monitoring records) to describe temporal, geographic, and demographic changes in drug overdoses in Kentucky...
June 27, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28734682/how-have-systematic-priority-setting-approaches-influenced-policy-making-a-synthesis-of-the-current-literature
#10
REVIEW
Lydia Kapiriri, Donya Razavi
BACKGROUND: There is a growing body of literature on systematic approaches to healthcare priority setting from various countries and different levels of decision making. This paper synthesizes the current literature in order to assess the extent to which program budgeting and marginal analysis (PBMA), burden of disease & cost-effectiveness analysis (BOD/CEA), multi-criteria decision analysis (MCDA), and accountability for reasonableness (A4R), are reported to have been institutionalized and influenced policy making and practice...
July 12, 2017: Health Policy
https://www.readbyqxmd.com/read/28732513/competing-for-space-in-an-already-crowded-market-a-mixed-methods-study-of-why-an-online-community-of-practice-cop-for-alcohol-harm-reduction-failed-to-generate-interest-amongst-the-group-of-public-health-professionals-at-which-it-was-aimed
#11
Ruth Ponsford, Jennifer Ford, Helena Korjonen, Emma Hughes, Asha Keswani, Triantafyllos Pliakas, Matt Egan
BACKGROUND: Improving mechanisms for knowledge translation (KT) and connecting decision-makers to each other and the information and evidence they consider relevant to their work remains a priority for public health. Virtual communities of practices (CoPs) potentially offer an affordable and flexible means of encouraging connection and sharing of evidence, information and learning among the public health community in ways that transgress traditional geographical, professional, institutional and time boundaries...
July 21, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28732321/aggregating-exposures-cumulating-risk-for-semivolatile-organic-compounds-a-review
#12
REVIEW
Maud Pelletier, Nathalie Bonvallot, Philippe Glorennec
Increasingly, health risk assessment is addressing multiple pathway exposures to multiple contaminants. We reviewed aggregated exposure and cumulative risk approaches for contemporary and ubiquitous semivolatile organic compounds (SVOC). We identified 22 studies aggregating exposure pathways, and 31 cumulating risk. Exposure aggregation is based on the addition of pathway-specific doses, using kinetic modeling where it exists, and classic external dose equations otherwise. In most cases, exposure is dominated by a single route or source of exposure - mainly the oral pathway - via dietary or non-dietary exposure...
July 18, 2017: Environmental Research
https://www.readbyqxmd.com/read/28728212/men-s-information-seeking-behaviour-regarding-cancer-risk-and-screening-a-meta-narrative-systematic-review
#13
REVIEW
Mohamad M Saab, Mary Reidy, Josephine Hegarty, Mairin O'Mahony, Mike Murphy, Christian Von Wagner, Frances J Drummond
OBJECTIVE: Preventive strategies are known to reduce cancer risk and incidence and improve prognosis. Men seldom seek medical information about cancer prevention and risk reduction. The aim of this meta-narrative systematic review was to critically appraise evidence from qualitative, quantitative, and mixed-methods studies that explored men's information-seeking behaviours in relation to cancer prevention and risk reduction. METHODS: MEDLINE, CINAHL Plus with Full Text, PsycINFO, PsycARTICLES, Psychology and Behavioral Sciences Collection, Education Full Text, and ERIC were systematically searched for studies published in English between January 1(st) 2006 and May 30(th) 2016...
July 20, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28727007/best-management-practices-for-newly-weaned-calves-for-improved-health-and-well-being
#14
B K Wilson, C J Richards, D L Step, C R Krehbiel
Morbidity and mortality in newly weaned calves resulting from bovine respiratory disease (BRD) continue to be the most significant problems facing the beef industry. Morbidity attributed to BRD accounts for approximately 75% of total feedlot morbidity. Several experiments have documented the economic impacts of BRD. Direct costs attributable to BRD include death loss, treatment and labor costs, and prevention costs, while indirect costs associated with BRD include decreased growth performance and feed efficiency, increased days on feed, and decreased carcass merit and market value...
May 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28725842/understanding-patients-process-to-use-medical-marijuana-a-southern-new-jersey-community-engagement-project
#15
Tara L Crowell
Given the necessity to better understand the process patients need to go through in order to seek treatment via medical marijuana, this study investigates this process to better understand this phenomenon. Specifically, Compassion Care Foundation (CCF) and Stockton University worked together to identify a solution to this problem. Specifically, 240 new patients at CCF were asked to complete a 1-page survey regarding various aspects associated with their experience prior to their use of medicinal marijuana-diagnosis, what prompted them to seek treatment, level of satisfaction with specific stages in the process, total length of time the process took, and patient's level of pain...
September 2016: Journal of patient experience
https://www.readbyqxmd.com/read/28725217/metagenomics-the-next-culture-independent-game-changer
#16
REVIEW
Jessica D Forbes, Natalie C Knox, Jennifer Ronholm, Franco Pagotto, Aleisha Reimer
A trend towards the abandonment of obtaining pure culture isolates in frontline laboratories is at a crossroads with the ability of public health agencies to perform their basic mandate of foodborne disease surveillance and response. The implementation of culture-independent diagnostic tests (CIDTs) including nucleic acid and antigen-based assays for acute gastroenteritis is leaving public health agencies without laboratory evidence to link clinical cases to each other and to food or environmental substances...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28724000/differences-and-inequalities-in-relation-to-access-to-renal-replacement-therapy-in-the-brics-countries
#17
Fábio Humberto Ribeiro Paes Ferraz, Cibele Isaac Saad Rodrigues, Giuseppe Cesare Gatto, Natan Monsores de Sá
End-stage renal disease (ESRD) is an important public health problem, especially in developing countries due to the high level of economic resources needed to maintain patients in the different programs that make up renal replacement therapy (RRT). To analyze the differences and inequalities involved in access to RRT in the BRICS countries (Brazil, Russian Federation, India, China and South Africa). This is an applied, descriptive, cross-sectional, quantitative and qualitative study, with documentary analysis and a literature review...
July 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28722771/navigating-and-negotiating-information-and-support-experiences-of-first-time-mothers
#18
Megan Aston, Sheri Price, Joelle Monaghan, Meaghan Sim, Andrea Hunter, Victoria Little
AIM: To examine how first time mothers in Nova Scotia (NS) identified and prioritized their own postpartum needs and where they went for information and support, inclusive of informal or formal programs and services, social media, family and friends. BACKGROUND: The early postpartum period is an exciting, yet stressful life experience for first time mothers. Mothers have often turned to families, friends and health care professionals for support and information; however, these social networks look differently today due to changes in institutional policies and postpartum health care practices, as well as the emergence of online resources and networks...
July 19, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28721954/out-of-pocket-health-expenditure-and-sources-of-financing-for-delivery-postpartum-and-neonatal-health-in-urban-slums-of-bhubaneswar-odisha-india
#19
Kirti Sundar Sahu, Bhavna Bharati
BACKGROUND: Out-of-pocket expenditure (OOPE) is an obstacle in the path of getting universal health coverage in India. OBJECTIVE: This study aimed to explore the OOPE, sources of funding, and experience of catastrophic expenditure (CE) for healthcare related to delivery, postpartum, and neonatal morbidity. METHODS: A community-based, cross-sectional survey was conducted among a sample of 240 recently delivered women from the slums of Bhubaneswar, Odisha...
April 2017: Indian Journal of Public Health
https://www.readbyqxmd.com/read/28721645/is-cancer-information-exchanged-on-social-media-scientifically-accurate
#20
Elizabeth A Gage-Bouchard, Susan LaValley, Molli Warunek, Lynda Kwon Beaupin, Michelle Mollica
Cancer patients and their caregivers are increasingly using social media as a platform to share cancer experiences, connect with support, and exchange cancer-related information. Yet, little is known about the nature and scientific accuracy of cancer-related information exchanged on social media. We conducted a content analysis of 12 months of data from 18 publically available Facebook Pages hosted by parents of children with acute lymphoblastic leukemia (N = 15,852 posts) and extracted all exchanges of medically-oriented cancer information...
July 19, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
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