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Nifedipine raynaud

C Matucci-Cerinic, V Nagaraja, F Prignano, B Kahaleh, S Bellando-Randone
Raynaud's phenomenon (RP) is a functional vascular disorder involving extremities. In his practice, the dermatologist may frequently encounter RP which affects mainly women and is categorized into a primary benign form and a secondary form associated with different diseases (infections, drugs, autoimmune and vascular conditions, haematologic, rheumatologic and endocrinologic disorders). Still today, the differential diagnosis is a clinical challenge. Therefore, a careful history and a physical examination, together with laboratory tests and nailfold capillaroscopy, is mandatory...
March 6, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
S Bellando-Randone, C Bruni, G Lepri, G Fiori, F Bartoli, M L Conforti, A Moggi-Pignone, S Guiducci, D Giuggioli, M Colaci, A Spinella, C Ferri, M Matucci-Cerinic
Iloprost (ILO) is employed intravenously for the treatment of severe Raynaud phenomenon (RP) and digital ulcers (DU) in systemic sclerosis (SSc). The aim of this study was to evaluate the safety and tolerability of the intravenous treatment with ILO in different phases of SSc. Eighty-one consecutive non-selected SSc patients, all on nifedipine, with moderate RP, treated with ILO infusion, were retrospectively evaluated. Patients were sub classified according to the edematous or fibrotic/atrophic cutaneous phase of the disease...
May 2018: Clinical Rheumatology
Ximena Wortsman, Pablo Del Barrio-Díaz, Rodrigo Meza-Romero, Christine Poehls-Risco, Cristián Vera-Kellet
No abstract text is available yet for this article.
January 2018: Journal of the American Academy of Dermatology
Fadumo Rirash, Paul C Tingey, Sarah E Harding, Lara J Maxwell, Elizabeth Tanjong Ghogomu, George A Wells, Peter Tugwell, Janet Pope
BACKGROUND: Raynaud's phenomenon is a vasospastic disease characterized by digital pallor, cyanosis, and extremity pain. Primary Raynaud's phenomenon is not associated with underlying disease, but secondary Raynaud's phenomenon is associated with connective tissue disorders such as systemic sclerosis, systemic lupus erythematosus, and mixed connective tissue disease. Calcium channel blockers promote vasodilation and are commonly used when drug treatment for Raynaud's phenomenon is required...
December 13, 2017: Cochrane Database of Systematic Reviews
Lu Wang, Qi-Song Lei, Yu-Ying Liu, Guan-Jie Song, Chun-Ling Song
OBJECTIVE: Raynaud phenomenon is a vasospastic disorder affecting the hands and feet, and the efficacies of traditional treatments, such as pharmacological therapies and sympathectomy, are not uniform. Patients with paraneoplastic Raynaud phenomenon do not benefit from the traditional treatments. The use of botulinum toxin type A (BTX-A) for Raynaud phenomenon has been reported for several years; however, there are few reports regarding botulinum toxin type A in the treatment of paraneoplastic Raynaud phenomenon...
October 2016: Medicine (Baltimore)
Carolin Zwadlo, Jürgen Borlak
Calcium channel blockers (CCB) differ in their effects on the cardiovascular system with diltiazem being less negatively ionotrop as compared to verapamil. Diltiazem is mainly used to treat supraventricular tachycardia, vasospastic angina and the Raynaud's syndrome. Little is known about the molecular effects of benzothiazepins on cardiac gene expression. We therefore investigated the effects of diltiazem on cardiac gene expression in normotensive and hypertensive rats with left ventricular hypertrophy and compared the results with our previous findings on verapamil and nifedipine...
December 2016: Vascular Pharmacology
Jyotiranjan Mallick, Lily Devi, Pradeep K Malik, Jogamaya Mallick
Normal tension glaucoma (NTG) is labelled when typical glaucomatous disc changes, visual field defects and open anterior chamber angles are associated with intraocular pressure (IOP) constantly below 21 mmHg. Chronic low vascular perfusion, Raynaud's phenomenon, migraine, nocturnal systemic hypotension and over-treated systemic hypertension are the main causes of normal tension glaucoma. Goldmann applanation tonometry, gonioscopy, slit lamp biomicroscopy, optical coherence tomography and visual field analysis are the main tools of investigation for the diagnosis of NTG...
April 2016: Journal of Ophthalmic & Vision Research
Léonard Golbin, Thibault Dolley-Hitze, Nolwenn Lorcy, Nathalie Rioux-Leclercq, Cécile Vigneau
Background. Acute interstitial nephritis (AIN) is a frequent cause of Acute Kidney Injury (AKI). Drug hypersensitivity is the most common etiology and the list of drugs that can induce AIN is not exhaustive yet. Case Report. Here, we describe the case of a 43-year-old man who was treated with nifedipine (Adalate®) for Raynaud's syndrome. After nifedipine introduction, serum creatininemia progressively increased from 91 to 188 μmol/L in a few months and AKI was diagnosed. Laboratory work-up results indicated the presence of tubular proteinuria and nonspecific inflammatory syndrome...
2016: Case Reports in Nephrology
Holly Ennis, Michael Hughes, Marina E Anderson, Jack Wilkinson, Ariane L Herrick
BACKGROUND: Calcium channel blockers are the most commonly prescribed drugs for people with primary Raynaud's phenomenon. Primary Raynaud's phenomenon is a common condition characterised by an exaggerated vasospastic response to cold or emotion: classically the digits (fingers and toes) turn white, then blue, then red. This is an update of the review first published in 2014. OBJECTIVES: To assess the effects of different calcium channel blockers for primary Raynaud's phenomenon as determined by attack rates, severity scores, participant-preference scores and physiological measurements...
February 25, 2016: Cochrane Database of Systematic Reviews
Paloma García de la Peña Lefebvre, María Betina Nishishinya, Claudia Alejandra Pereda, Estíbaliz Loza, Walter Alberto Sifuentes Giraldo, José Andrés Román Ivorra, Patricia Carreira, Iñigo Rúa-Figueroa, Jose María Pego-Reigosa, Santiago Muñoz-Fernández
To evaluate the efficacy of current treatments for the Raynaud phenomenon (RP) in patients with systemic sclerosis (SSc), a systematic literature search was performed using Medline, EMBASE, and Cochrane Central Register of Controlled Trials (from 1961 to October 2011). We included meta-analyses, systematic reviews, clinical trials, and high-quality cohort studies published in English or Spanish. Patient populations had to include adults diagnosed with limited cutaneous or diffuse SSc who had associated RP and/or digital ulcers under pharmacological treatment...
September 2015: Rheumatology International
O Levy, I Maslakov, S Vosco, A Markov, M Amit-Vazina, M Tishler
A 35-year-old female with long standing aPL-positive lupus without history of thromboembolic events, who has developed critical peripheral ischemia (CPI) is described. An episode of severe Raynaud's phenomenon rapidly progressed to an extensive digit-threatening ischemia, involving bilateral hands and feet. She was successfully treated with corticosteroids, anticoagulation, iloprost, sildenafil, and nifedipine. Her serological studies were remarkable for the emergence of high titer anti-RNP seroconversion and an increase in aPL titer, suggesting that these autoantibodies played a role in the pathogenesis of CPI...
March 2015: Lupus
Jung-Chul Seo, Hyun-jong Lee, Min-Ah Kwak, Sung-Hoon Park, ImHee Shin, Woo-Sung Yun, Kihyuk Park
BACKGROUND: Cold hands sensation is a common disorder within the Korean population. Many Korean family physicians believe that it is a mild early manifestation of Raynaud's phenomenon (RP), or may be related to RP. RP is characterized by reversible digital vasospasm provoked by cold temperatures and/or emotional stress, and doctors often prescribe medications that are used in treatment of RP for subjects with cold hands. However, this has not shown a clear benefit, and these medications can cause unwanted side effects...
September 4, 2014: Trials
Jacob M Rosenberg, Ralph Rosenberg
A 69-year-old woman presented with bilateral digital necrosis, which had developed over a period of 2 months (Panels A and B). One year earlier, new-onset Sjögren's syndrome and painful Raynaud's phenomenon had developed. Nifedipine and topical nitroglycerin failed to improve symptoms. The patient..
March 20, 2014: New England Journal of Medicine
Holly Ennis, Marina E Anderson, Jack Wilkinson, Ariane L Herrick
BACKGROUND: Calcium channel blockers are the most commonly prescribed drugs for people with primary Raynaud's phenomenon. Primary Raynaud's phenomenon is a common condition characterised by an exaggerated vasospastic response to cold or emotion: classically the digits (fingers and toes) turn white, then blue, then red. OBJECTIVES: To assess the effects of different calcium channel blockers for primary Raynaud's phenomenon as determined by attack rates, severity scores, participant-preference scores and physiological measurements...
January 30, 2014: Cochrane Database of Systematic Reviews
Ronald R Butendieck, Peter M Murray
No abstract text is available yet for this article.
January 2014: Journal of Hand Surgery
Janet Pope
INTRODUCTION: Raynaud's phenomenon is an episodic, reversible vasospasm of the peripheral arteries (usually digital). It causes pallor, followed by cyanosis and/or redness, often with pain and, at times, paraesthesia. On rare occasions, it can lead to ulceration of the fingers and toes (and, in some cases, of the ears or nose). This review focuses on primary (idiopathic) Raynaud's phenomenon, occurring in the absence of an underlying disease. The prevalence of primary Raynaud's phenomenon varies by sex, country, and exposure to workplace vibration...
October 10, 2013: Clinical Evidence
Meagan E Barrett, Misha M Heller, Honor Fullerton Stone, Jenny E Murase
OBJECTIVE: To elucidate the diagnostic criteria of Raynaud phenomenon of the nipple that will aid in recognizing and treating Raynaud phenomenon in breast feeding mothers with chronic deep nipple pain during lactation. DESIGN: Retrospective review of a patient database composed of 22 cases of breastfeeding mothers who fit the diagnostic criteria for Raynaud phenomenon of the nipple. SETTING: Menlo Dermatology Medical Group in Menlo Park, California, an academic-affiliated, private dermatologic referral center...
March 2013: JAMA Dermatology
Shin-Seok Yang, Keun-Myoung Park, Young-Wook Kim, Dong-Ik Kim
We assessed the utility of a 3-grade classification of photoplethysmography (PPG) with cold water provocation test in Raynaud phenomenon (RP). A total of 35 patients with RP and 38 healthy volunteers were recruited. In healthy volunteers, PPG was measured twice at intervals of 30 minutes for evaluating reproducibility of test. Percentage variation of the PPG amplitude in post- versus precold provocation was expressed on a 3-grade scale at 1, 3, and 5 minutes (reflection index: RI) in patients with RP. The improvement pattern of the PPG (IPPPG) was evaluated by summing the score differences from RI1 min to RI3 min and RI5 min...
November 2013: Angiology
Rebeca Iglesias Barreira, Belén Bardán García, Mónica Granero López, Iria Rodríguez Legazpi, Hortensia Álvarez Díaz, Isaura Rodríguez Penín
OBJECTIVE: To report a paradoxical reaction of Raynaud phenomenon following the repeated administration of iloprost in a patient with diffuse cutaneous systemic sclerosis with vascular involvement. CASE SUMMARY: In January 2006, a 40-year-old male was diagnosed with diffuse cutaneous systemic sclerosis with pulmonary, esophageal, cutaneous, and vascular involvement (Raynaud phenomenon, with digital ulcers on his hands). In December 2008, treatment with iloprost was started due to worsening disease...
October 2012: Annals of Pharmacotherapy
Charalampos Seretis, Fotios Seretis, George Gemenetzis, Nikolaos Liakos, Apostolos Pappas, Stavros Gourgiotis, Emmanuel Lagoudianakis, Dimitrios Keramidaris, Nikolaos Salemis
Esophageal sclerosis is the most common visceral manifestation of systemic sclerosis, resulting in impaired esophageal clearance and retention of ingested food; in addition, co-existence of lung fibrosis with esophageal scleroderma is not uncommon. Both the progression of generalized connective tissue disorders and the damaging effect of chronic aspiration due to esophageal dysmotility appear to be involved in this procedure of interstitial fibrosis. Nifedipine is a widely prescribed calcium antagonist in a significant percentage of rheumatologic patients suffering from Raynaud syndrome, in order to inhibit peripheral vasospasm...
January 2012: Case Reports in Gastroenterology
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