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https://www.readbyqxmd.com/read/27933429/establishing-the-values-for-patient-engagement-pe-in-health-related-quality-of-life-hrqol-research-an-international-multiple-stakeholder-perspective
#1
Kirstie Haywood, Anne Lyddiatt, Samantha J Brace-McDonnell, Sophie Staniszewska, Sam Salek
PURPOSE: Active patient engagement is increasingly viewed as essential to ensuring that patient-driven perspectives are considered throughout the research process. However, guidance for patient engagement (PE) in HRQoL research does not exist, the evidence-base for practice is limited, and we know relatively little about underpinning values that can impact on PE practice. This is the first study to explore the values that should underpin PE in contemporary HRQoL research to help inform future good practice guidance...
December 8, 2016: Quality of Life Research
https://www.readbyqxmd.com/read/27932553/normalization-matters-tracking-the-best-strategy-for-sperm-mirna-quantification
#2
Celia Corral-Vazquez, Joan Blanco, Albert Salas-Huetos, Francesca Vidal, Ester Anton
STUDY QUESTION: What is the most reliable normalization strategy for sperm microRNA (miRNA) quantitative Reverse Transcription Polymerase Chain Reactions (qRT-PCR) using singleplex assays? SUMMARY ANSWER: The use of the average expression of hsa-miR-100-5p and hsa-miR-30a-5p as sperm miRNA qRT-PCR data normalizer is suggested as an optimal strategy. WHAT IS KNOWN ALREADY: Mean-centering methods are the most reliable normalization strategies for miRNA high-throughput expression analyses...
December 8, 2016: Molecular Human Reproduction
https://www.readbyqxmd.com/read/27931252/the-impact-of-advertising-patient-and-public-involvement-on-trial-recruitment-embedded-cluster-randomised-recruitment-trial
#3
Adwoa Hughes-Morley, Mark Hann, Claire Fraser, Oonagh Meade, Karina Lovell, Bridget Young, Chris Roberts, Lindsey Cree, Donna More, Neil O'Leary, Patrick Callaghan, Waquas Waheed, Peter Bower
BACKGROUND: Patient and public involvement in research (PPIR) may improve trial recruitment rates, but it is unclear how. Where trials use PPIR to improve design and conduct, many do not communicate this clearly to potential participants. Better communication of PPIR might encourage patient enrolment, as trials may be perceived as more socially valid, relevant and trustworthy. We aimed to evaluate the impact on recruitment of directly advertising PPIR to potential trial participants. METHODS: This is a cluster trial, embedded within a host trial ('EQUIP') recruiting service users diagnosed with severe mental illness...
December 8, 2016: Trials
https://www.readbyqxmd.com/read/27929424/a-height-estimation-approach-for-terrain-following-flights-from-monocular-vision
#4
Igor S G Campos, Erickson R Nascimento, Gustavo M Freitas, Luiz Chaimowicz
In this paper, we present a monocular vision-based height estimation algorithm for terrain following flights. The impressive growth of Unmanned Aerial Vehicle (UAV) usage, notably in mapping applications, will soon require the creation of new technologies to enable these systems to better perceive their surroundings. Specifically, we chose to tackle the terrain following problem, as it is still unresolved for consumer available systems. Virtually every mapping aircraft carries a camera; therefore, we chose to exploit this in order to use presently available hardware to extract the height information toward performing terrain following flights...
December 6, 2016: Sensors
https://www.readbyqxmd.com/read/27928642/the-importance-of-evidence-based-supportive-care-practice-guidelines-in-childhood-cancer-a-plea-for-their-development-and-implementation
#5
E A H Loeffen, L C M Kremer, R L Mulder, A Font-Gonzalez, L L Dupuis, L Sung, P D Robinson, M D van de Wetering, W J E Tissing
As cure rates in pediatric oncology have improved substantially over the last decades, supportive care has become increasingly important to reduce morbidity and mortality and improve quality of life in children with cancer. Currently, large variations exist in pediatric oncology supportive care practice, which might negatively influence care. This plea underlines the importance of development and implementation of trustworthy supportive care clinical practice guidelines, which we believe is the essential next step towards better supportive care practice, and thus a higher quality of care...
December 8, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27928442/creating-the-ideal-patient-experience
#6
Purcărea Th V
Healthcare industry continues to evolve under conditions of intense competition in approaching health prevention, protection, and promotion. Therefore, healthcare providers are challenged to always ensure better patient experience, winning patients' satisfaction, and loyalty and remain competitive on today's healthcare market. Healthcare markets bring together professionals and their patients into real collaborative relationships, which empower patients to contribute to the healthcare improvement. Within this competitive landscape, which is also characterized by digital health tools boosting patients' awareness and controlling their own health, medical providers need to be perceived as skilled and trustworthy in relying on patients' needs, expectations, and sacrifices are required in order to obtain the promised benefits...
October 2016: Journal of Medicine and Life
https://www.readbyqxmd.com/read/27920357/use-of-a-bogus-pipeline-to-detect-men-s-underreporting-of-sexually-aggressive-behavior
#7
Emily Strang, Zoë D Peterson
Researchers rely on men's self-reports of sexually aggressive behavior to identify the prevalence and correlates of men's perpetration (i.e., their use of verbal or physical coercion to obtain sex from a nonconsenting partner). However, results from research based on men's self-reported sexual perpetration are suspect because men may intentionally conceal their sexually aggressive behavior. The current study used a Bogus Pipeline (BPL) methodology to determine whether young, community men (N = 93) intentionally underreport their use of sexually aggressive strategies on two self-report measures of perpetration...
December 4, 2016: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/27919393/business-analysis-for-a-sustainable-multi-stakeholder-ecosystem-for-leveraging-the-electronic-health-records-for-clinical-research-ehr4cr-platform-in-europe
#8
Danielle Dupont, Ariel Beresniak, Mats Sundgren, Andreas Schmidt, John Ainsworth, Pascal Coorevits, Dipak Kalra, Marc Dewispelaere, Georges De Moor
INTRODUCTION: The Electronic Health Records for Clinical Research (EHR4CR) technological platform has been developed to enable the trustworthy reuse of hospital electronic health records data for clinical research. The EHR4CR platform can enhance and speed up clinical research scenarios: protocol feasibility assessment, patient identification for recruitment in clinical trials, and clinical data exchange, including for reporting serious adverse events. Our objective was to seed a multi-stakeholder ecosystem to enable the scalable exploitation of the EHR4CR platform in Europe, and to assess its economic sustainability...
January 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/27910997/service-user-satisfaction-with-cognitive-behavioural-therapy-for-psychosis-associations-with-therapy-outcomes-and-perceptions-of-the-therapist
#9
Caroline Lawlor, Bina Sharma, Mizanur Khondoker, Emmanuelle Peters, Elizabeth Kuipers, Louise Johns
OBJECTIVES: Few studies have investigated service user satisfaction with cognitive behavioural therapy for psychosis (CBTp). This study explored its associations with clinical presentation and outcomes, retrospective expectations of progress, perceptions of the therapist, and demographic variables. DESIGN AND METHODS: One hundred and sixty-five service users completed self-report questionnaires pre- and post-CBTp in relation to the constructs of interest. Regression analyses explored associations with (1) overall satisfaction with therapy and (2) perceived progress, skills, and knowledge gained...
December 2, 2016: British Journal of Clinical Psychology
https://www.readbyqxmd.com/read/27907958/critical-care-management-after-cardiac-arrest
#10
Hans Friberg, Tobias Cronberg
Sudden cardiac arrest is a devastating event with high mortality and substantial morbidity among survivors. Early recognition and intervention to restore circulation is the primary goal; once that is achieved, the path toward a meaningful recovery starts. Initial in-hospital care is focused on emergency cardiac care, but soon there is a change to a more brain-oriented critical care including targeted temperature management, brain monitoring, sedation, and repeated neurologic assessments. In patients who show early signs of awakening from coma once sedation has been stopped, the prognosis is generally good...
December 2016: Seminars in Neurology
https://www.readbyqxmd.com/read/27906996/reach-the-person-behind-the-dementia-physical-therapists-reflections-and-strategies-when-composing-physical-training
#11
Anncristine Fjellman-Wiklund, Ellinor Nordin, Dawn A Skelton, Lillemor Lundin-Olsson
Dementia is a disease characterized by cognitive impairment and physical decline that worsens over time. Exercise is one lifestyle factor that has been identified as a potential means of reducing or delaying progression of the symptoms of dementia, maximizing function and independence. The purpose of this study was to explore physical therapists' (PTs) experiences and reflections on facilitating high-intensity functional exercise with older people living with dementia, in residential care home settings. The study used a qualitative design based on interviews, individually or in small groups, with seven PTs engaged as leaders in the training of older people with dementia...
2016: PloS One
https://www.readbyqxmd.com/read/27901595/conflict-of-interest-policies-and-industry-relationships-of-guideline-development-group-members-a-cross-sectional-study-of-clinical-practice-guidelines-for-depression
#12
Lisa Cosgrove, Sheldon Krimsky, Emily E Wheeler, Shannon M Peters, Madeline Brodt, Allen F Shaughnessy
Because of increased attention to the issue of trustworthiness of clinical practice guidelines, it may be that both transparency and management of industry associations of guideline development groups (GDGs) have improved. The purpose of the present study was to assess a) the disclosure requirements of GDGs in a cross-section of guidelines for major depression; and, b) the extent and type of conflicts of panel members. Treatment guidelines for major depression were identified and searched for conflict of interest policies and disclosure statements...
October 24, 2016: Accountability in Research
https://www.readbyqxmd.com/read/27899230/experimental-zika-virus-infection-induces-spinal-cord-injury-and-encephalitis-in-newborn-swiss-mice
#13
Natália C C A Fernandes, Juliana S Nogueira, Rodrigo A Réssio, Cinthya S Cirqueira, Lidia M Kimura, Karolina R Fernandes, Mariana S Cunha, Renato P Souza, Juliana M Guerra
A widespread epidemic of Zika virus (ZIKV) infection was reported in 2015 in South and Central America, with neurological symptons including meningoencephalitis and Guillain-Barré syndrome in adults, besides an apparent increased incidence of microcephaly in infants born to infected mothers. It is becoming a necessity to have a trustworthy animal model to better understand ZIKV infection. In this study we used newborn white Swiss mice as a model to investigate the ZIKV strain recently isolated in Brazil. ZIKV was inoculated via intracerebral and subcutaneous routes and analysed through gross histopathology and immunohistochemistry...
November 26, 2016: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/27898705/the-role-of-the-amygdala-in-facial-trustworthiness-processing-a-systematic-review-and-meta-analyses-of-fmri-studies
#14
Sara Santos, Inês Almeida, Bárbara Oliveiros, Miguel Castelo-Branco
BACKGROUND: Faces play a key role in signaling social cues such as signals of trustworthiness. Although several studies identify the amygdala as a core brain region in social cognition, quantitative approaches evaluating its role are scarce. OBJECTIVES: This review aimed to assess the role of the amygdala in the processing of facial trustworthiness, by analyzing its amplitude BOLD response polarity to untrustworthy versus trustworthy facial signals under fMRI tasks through a Meta-analysis of effect sizes (MA)...
2016: PloS One
https://www.readbyqxmd.com/read/27893823/shared-decision-making-at-the-limit-of-viability-a-blueprint-for-physician-action
#15
Thierry Daboval, Sarah Shidler, Daniel Thomas
OBJECTIVE: To document interactions during the antenatal consultation between parents and neonatologist that parents linked to their satisfaction with their participation in shared decision making for their infant at risk of being born at the limit of viability. METHODS: This multiple-case ethnomethodological qualitative research study, included mothers admitted for a threatened premature delivery between 200/7 and 266/7 weeks gestation, the father, and the staff neonatologist conducting the clinical antenatal consultation...
2016: PloS One
https://www.readbyqxmd.com/read/27891336/mycobacterium-tuberculosis-beijing-genotype-in-western-iran-distribution-and-drug-resistance
#16
Parviz Mohajeri, Sakineh Moradi, Sara Atashi, Abbas Farahani
INTRODUCTION: Mycobacterium tuberculosis Beijing genotype is gaining importance all over the world because this genotype is highly prevalent in several areas and is also frequently associated with drug resistance. AIM: To identify and determine the frequency of Beijing genotype and mix infection with Beijing and non-Beijing in west of Iran and analyse the association between Beijing genotype and drug resistance. MATERIALS AND METHODS: This cross-sectional study was conducted on 146 Tuberculosis (TB) samples collected at the TB reference laboratory in Kermanshah west of Iran from January 2014 to February 2015, Mycobacterium tuberculosis isolates from sputum samples, detected by microcopy, biochemical tests and solid culture were included and then the confirmed samples with Cepheid Xpert MTB/RIF assay were subjected to drug susceptibility tests for rifampicin, isoniazid, ethambutol using proportional method...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27890120/influence-of-lane-departure-warnings-onset-and-reliability-on-car-drivers-behaviors
#17
J Navarro, J Deniel, E Yousfi, C Jallais, M Bueno, A Fort
Lane departures represent an important cause of road crashes. The objective of the present study was to assess the effects of an auditory Lane Departure Warning System (LDWS) for partial and full lane departures (onset manipulation) combined with missed warnings (reliability manipulation: 100% reliable, 83% reliable and 66% reliable) on drivers' performances and acceptance. Several studies indicate that LDWS improves drivers' performances during lane departure episodes. However, little is known about the effects of the warning onset and reliability of LDWS...
March 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/27887861/bias-in-the-reporting-of-harms-in-clinical-trials-of-second-generation-antidepressants-the-tip-of-the-iceberg
#18
Alain Braillon, Florian Naudet
Serious adverse events are poorly reported in clinical trials of second-generation antidepressants. Moreover some key opinion leaders (eg. in France) deliberately failed to warn against them. The gross distortions of antidepressants' benefit:harm ratio in adolescents showed evidence that open science (ie access to de-identified individual patient data for re-analyses) is a mandatory prerequisite for a trustworthy science.
November 22, 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27883329/how-to-recognize-and-avoid-potential-possible-or-probable-predatory-open-access-publishers-standalone-and-hijacked-journals
#19
Lenche Danevska, Mirko Spiroski, Doncho Donev, Nada Pop-Jordanova, Momir Polenakovic
INTRODUCTION AND AIM: The Internet has enabled an easy method to search through the vast majority of publications and has improved the impact of scholarly journals. However, it can also pose threats to the quality of published articles. New publishers and journals have emerged so-called open-access potential, possible, or probable predatory publishers and journals, and so-called hijacked journals. It was our aim to increase the awareness and warn scholars, especially young researchers, how to recognize these journals and how to avoid submission of their papers to these journals...
November 1, 2016: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/27881105/open-trusting-relationships-underpin-safety-in-rural-maternity-a-hermeneutic-phenomenology-study
#20
Susan Crowther, Elizabeth Smythe
BACKGROUND: There are interwoven personal, professional and organisational relationships to be navigated in maternity in all regions. In rural regions relationships are integral to safe maternity care. Yet there is a paucity of research on how relationships influence safety and nurture satisfying experiences for rural maternity care providers and mothers and families in these regions. This paper draws attention to how these relationships matter. METHODS: This research is informed by hermeneutic phenomenology drawing on Heidegger and Gadamer...
November 24, 2016: BMC Pregnancy and Childbirth
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