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Xanthones

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https://www.readbyqxmd.com/read/28895799/protective-effects-of-bellidifolin-in-hypoxia-induced-in-pheochromocytoma-cells-pc12-and-underlying-mechanisms
#1
Zhi-Ying Zhao, Yang-Yang Gao, Li Gao, Ming Zhang, He Wang, Chun-Hong Zhang
Bellidifolin, a xanthone compound derived from plants of Gentiana species, is known to exert a variety of pharmacological activities including anti-oxidation, anti-inflammatory and antitumor actions as well as a protective effect on cerebral ischemic nerve injury. The aim of this study was to examine the protective effects of bellidifolin on nerve injury produced by hypoxia and possible underlying mechanisms using pheochromocytoma cells (PC12). Data showed that the viability of PC12 cells subjected to hypoxia resulted in a significant decrease; however; pretreatment with certain concentrations of bellidifolin (20 or 40 μmol/L) prior to hypoxia significantly increased the survival rate...
September 12, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28878295/garcinone-e-induces-apoptosis-and-inhibits-migration-and-invasion-in-ovarian-cancer-cells
#2
Xiao-Huang Xu, Qian-Yu Liu, Ting Li, Jian-Lin Liu, Xin Chen, Li Huang, Wen-An Qiang, Xiuping Chen, Yitao Wang, Li-Gen Lin, Jin-Jian Lu
Ovarian cancer remains the most lethal gynecological malignant tumor. In this study, 24 xanthones were isolated and identified from the pericarps of mangosteen (Garcinia mangostana), and their anti-proliferative activities were tested in ovarian cancer cells. Garcinone E (GE) was found to exhibit excellent anti-proliferative effects among the tested xanthones. It significantly inhibited the proliferation in HEY, A2780, and A2780/Taxol cells as evidenced by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, lactate dehydrogenase (LDH) release assay, Hoechst 33342 staining, annexin V/PI staining, and JC-1 staining...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28868928/xanthones-isolated-from-gentianella-acuta-and-their-protective-effects-against-h2o2-induced-myocardial-cell-injury
#3
Zhibin Wang, Gaosong Wu, Ying Yu, Hua Liu, Bingyou Yang, Haixue Kuang, Qiuhong Wang
In the present study, two new xanthones, (5'S,8'S)-1,3,5,8-tetrahydroxyxanthone(7→2')-1,3,5,8-tetrahydroxy-5',6',7',8'-tetrahydroxanthone (1), 5-hydroxy-3,4,6-trimethoxyxanthone-1-O-β-D-glucopyranoside (2), and eight known xanthones (3-10) were isolated from the whole plants of Gentianella acuta. Their structures were identified by the spectroscopic analyses (HR-ESI-MS, and 1D and 2D NMR). Meanwhile, cell-protective effects against H2O2-induced H9c2 cardiomyocyte injury and cytotoxic activities of compounds 1-10 were also determined...
September 4, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28861624/docking-assisted-3d-qsar-studies-on-xanthones-as-%C3%AE-glucosidase-inhibitors
#4
Xuehua Zheng, Siyuan Zhou, Chen Zhang, Deyan Wu, Hai-Bin Luo, Yinuo Wu
Recently, a series of xanthone analogues has been identified as α-glucosidase inhibitors. To provide deeper insight into the three-dimensional (3D) structural requirements for the activities of these molecules, CoMFA and CoMSIA approaches were employed on 54 xanthones to construct 3D-QSAR models. Their bioactive conformations were first investigated by docking studies and optimized by subsequent molecular dynamics (MD) simulations using the homology modeled structure of the target protein. Based on the docking/MD-determined conformers, 3D-QSAR studies generated several significant models in terms of 47 molecules as the training set...
August 31, 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28842267/medicinal-properties-of-mangosteen-garcinia-mangostana-l-a-comprehensive-update
#5
REVIEW
Berenice Ovalle-Magallanes, Dianelena Eugenio-Pérez, José Pedraza-Chaverri
Garcinia mangostana L. (Clusiaceae) is a tropical tree native to Southeast Asia known as mangosteen which fruits possess a distinctive and pleasant taste that has granted them the epithet of "queen of the fruits". The seeds and pericarps of the fruit have a long history of use in the traditional medicinal practices of the region, and beverages containing mangosteen pulp and pericarps are sold worldwide as nutritional supplements. The main phytochemicals present in the species are isoprenylated xanthones, a class of secondary metabolites with multiple reports of biological effects, such as antioxidant, pro-apoptotic, anti-proliferative, antinociceptive, anti-inflammatory, neuroprotective, hypoglycemic and anti-obesity...
August 24, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28832188/dual-multitargeted-xanthone-derivatives-for-alzheimer-s-disease-where-do-we-stand
#6
Maria I Cruz, Honorina Cidade, Madalena Pinto
To date, the current therapy for Alzheimer's disease (AD) based on acetylcholinesterase inhibitors is only symptomatic, being its efficacy limited. Hence, the recent research has been focused in the development of different pharmacological approaches. Here we discuss the potential of xanthone derivatives as new anti-Alzheimer agents. The interference of xanthone derivatives with acetylcholinesterase and other molecular targets and cellular mechanisms associated with AD have been recently systematically reported...
August 23, 2017: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/28826239/isolation-and-structural-modifications-of-ananixanthone-from-calophyllum-teysmannii-and-their-cytotoxic-activities
#7
Lee Kar Wei, Nor Hisam Zamakshshari, Gwendoline Cheng Lian Ee, Siau Hui Mah, Siti Mariam Mohd Nor
Two naturally occurring xanthones, ananixanthone (1) and β-mangostin (2), were isolated using column chromatographic method from the n-hexane and methanol extracts of Calophyllum teysmannii, respectively. The major constituent, ananixanthone (1), was subjected to structural modifications via acetylation, methylation and benzylation yielding four new xanthone derivatives, ananixanthone monoacetate (3), ananixanthone diacetate (4), 5-methoxyananixanthone (5) and 5-O-benzylananixanthone (6). Compound 1 together with its four new derivatives were subjected to MTT assay against three cancer cell lines; SNU-1, K562 and LS174T...
August 22, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28797884/drifting-of-heme-coordinating-group-in-imidazolylmethylxanthones-leading-to-improved-selective-inhibition-of-cyp11b1
#8
Silvia Gobbi, Qingzhong Hu, Christina Zimmer, Federica Belluti, Angela Rampa, Rolf W Hartmann, Alessandra Bisi
An abnormal increase in glucocorticoid levels is responsible for pathological disorders affecting different organs and systems, and the selective inhibition of appropriate steroidogenic enzymes represents a validated strategy to restore their physiological levels. In continuing our studies on CYP11B inhibitors, in this paper a small series of 6-substituted 3-imidazolylmethylxanthones was designed and synthesized, according to the data acquired from previously reported series of derivatives and from a purposely-performed docking study...
August 2, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28747567/modulation-of-the-nur77-bcl-2-apoptotic-pathway-by-p38%C3%AE-mapk
#9
Jie Liu, Guang-Hui Wang, Ying-Hui Duan, Yi Dai, Yuzhou Bao, Mengjie Hu, Yu-Qi Zhou, Mingyu Li, Fuquan Jiang, Hu Zhou, Xin-Sheng Yao, Xiao-Kun Zhang
Orphan nuclear receptor Nur77 promotes apoptosis by targeting mitochondria through interaction with Bcl-2, an event that converts Bcl-2 from a survival to killer. However, how the Nur77-Bcl-2 apoptotic pathway is regulated remains largely unknown. In this study, we examined the regulation of the Nur77-Bcl-2 pathway by CCE9, a xanthone compound. Our results demonstrated that the apoptotic effect of CCE9 depended on its induction of Nur77 expression, cytoplasmic localization, and mitochondrial targeting. The activation of the Nur77-Bcl-2 pathway by CCE9 was associated with its activation of p38α MAPK...
July 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28741279/identification-of-lead-molecules-in-garcinia-mangostana-l-against-pancreatic-cholesterol-esterase-activity-an-in-silico-approach
#10
George Kadakasseril Varghese, Rini Abraham, Nisha N Chandran, Solomon Habtemariam
Hypercholesterolemia is one of the major risk factors for the development and progression of atherosclerosis. Hence, inhibitors of cholesterol absorption have been investigated for decades as a strategy to prevent and treat cardiovascular diseases associated with hypercholesterolemia. Cholesterol esterase (CEase) in pancreatic juice plays a vital role in the hydrolysis of dietary cholesterol esters to cholesterol and fatty acids. Since inhibition of CEase might lead to a reduction of cholesterol absorption, an attempt is made in this study to identify lead molecules of Garcinia mangostana by the in silico approach...
July 24, 2017: Interdisciplinary Sciences, Computational Life Sciences
https://www.readbyqxmd.com/read/28729053/bioactive-polyprenylated-benzophenone-derivatives-from-the-fruits-extracts-of-garcinia-xanthochymus
#11
Ui Joung Youn, Tawanun Sripisut, Gabriella Miklossy, James Turkson, Surat Laphookhieo, Leng Chee Chang
Two new polycyclic prenylated xanthones (1 and 2) and a new phenylpropanoid glycoside (3), along with seven known compounds (4-10) were isolated from the fruits of Garcinia xanthochymus. The structures were elucidated by 1D- and 2D-NMR, and HRMS experiments. The isolates were evaluated for their inhibitory effects against the viability of U251MG glioblastoma and MDA-MB-231 breast cancer cells that harbor an aberrantly active signal transducer and exhibit activation of transcription 3 (STAT3), and compared to normal NIH3T3 mouse fibroblasts...
August 15, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28722351/%C3%AE-mangostin-suppresses-human-hepatocellular-carcinoma-cell-invasion-through-inhibition-of-mmp-2-and-mmp-9-expression-and-activating-the-erk-and-jnk-pathways
#12
Chien-Feng Huang, Ying-Hock Teng, Fung-Jou Lu, Wen-Hung Hsu, Chia-Liang Lin, Chia-Chen Hung, Jai-Nien Tung, Yi-Hsien Hsieh, Chung-Jung Liu
β-mangostin is a dietary xanthone that has been reported to have the anticancer properties in some human cancer cell types. However, the antimetastatic effect and molecular mechanism of β-mangostin action in human hepatocellular carcinoma (HCC) cells remain unknown. In this study, we found that β-mangostin did not induce cytotoxicity in human HCC cells (SK-Hep-1, Huh-7 and HA22T/VGH cells). β-mangostin could inhibit migration and invasion of human HCC cells. Meanwhile, β-mangostin significantly decreased the protein activities and expression of matrix metalloproteinase (MMP)-2 and MMP-9 via increasing the activation of MEK1/2, ERK1/2, MEK4 and JNK1/2 signaling pathways...
July 19, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28716572/dpph-hplc-ms-assisted-rapid-identification-of-endothelial-protective-substances-from-xiao-ke-an
#13
Zhenzhong Yang, Zhenhao Li, Zheng Li
ETHNOPHARMACOLOGICAL RELEVANCE: Xiao-Ke-An formula (XKA) is a Chinese medicine widely used for treating diabetes and associated complications. Endothelial protection is thought to be one of its therapeutic mechanisms. However, the protective effect of XKA on endothelial cells remains unclear, especially in oxidative injury induced endothelial dysfunction. MATERIALS AND METHODS: A novel strategy to rapidly screen and identify potential endothelial protective substances from XKA was established by combining the 2,2'-diphenyl-1-picrylhydrazyl high performance liquid chromatography coupled with mass spectrometry (DPPH-HPLC-MS) approach with cell-based verification...
July 14, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28716025/beta-mangostin-demonstrates-apoptogenesis-in-murine-leukaemia-wehi-3-cells-in-vitro-and-in-vivo
#14
Fatima Abdelmutaal Ahmed Omer, Najihah Mohd Hashim, Mohamed Yousif Ibrahim, Abdulmannan F Aldoubi, Pouya Hassandarvish, Firouzeh Dehghan, Noraziah Nordin, Hamed Karimian, Landa Zeenelabdin Ali Salim, Mahmood Ameen Abdulla, Karim Al-Jashamy, Syam Mohan
BACKGROUND: Beta-mangostin (BM) is a xanthone-type of natural compound isolated from Cratoxylum arborescens. This study aimed to examine the apoptosis mechanisms induced by BM in a murine monomyelocytic cell line (WEHI-3) in vitro and in vivo. METHODS: A WEHI-3 cell line was used to evaluate the cytotoxicity of BM by MTT. AO/PI and Hoechst 33342 dyes, Annexin V, multiparametric cytotoxicity 3 by high content screening (HCS); cell cycle tests were used to estimate the features of apoptosis and BM effects...
July 17, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28700682/circumscription-of-the-genus-lepra-a-recently-resurrected-genus-to-accommodate-the-variolaria-group-of-pertusaria-sensu-lato-pertusariales-ascomycota
#15
Xinli Wei, Imke Schmitt, Brendan Hodkinson, Adam Flakus, Martin Kukwa, Pradeep K Divakar, Paul M Kirika, Jürgen Otte, Anjuli Meiser, H Thorsten Lumbsch
Pertusarialean lichens include more than 300 species belonging to several independent phylogenetic lineages. Only some of these phylogenetic clades have been comprehensively sampled for molecular data, and formally described as genera. Here we present a taxonomic treatment of a group of pertusarialean lichens formerly known as "Pertusaria amara-group", "Monomurata-group", or "Variolaria-group", which includes widespread and well-known taxa such as P. amara, P. albescens, or P. ophthalmiza. We generated a 6-locus data set with 79 OTUs representing 75 species...
2017: PloS One
https://www.readbyqxmd.com/read/28686977/cardioprotective-effect-of-the-xanthones-from-gentianella-acuta-against-myocardial-ischemia-reperfusion-injury-in-isolated-rat-heart
#16
Zhibin Wang, Gaosong Wu, Hua Liu, Na Xing, Yanping Sun, Yadong Zhai, Bingyou Yang, Ah-Ng Tony Kong, Haixue Kuang, Qiuhong Wang
Gentianella acuta (Michx.) Hulten is widely used for the treatment of arrhythmia and coronary heart disease in Ewenki Folk Medicinal Plants and Mongolian Medicine, popularly known as "Wenxincao" in China. To investigate the potential protective role of the xanthones from G. acuta against myocardial I/R injury in isolated rat heart and its possible related mechanism. The protective role of xanthones on myocardial I/R injury was studied on Langendorff apparatus. The hemodynamic parameters including the left ventricular developed pressure (LVDP), the maximum rate of up/down left intraventricular pressure (±dp/dtmax), coronary flow (CF) and heart rate (HR) were recorded during the perfusion...
September 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28677899/validated-lc-ms-ms-method-for-quantitation-of-demethylbellidifolin-in-rat-plasma-and-its-application-to-pharmacokinetic-and-bioavailability-studies
#17
Jie Zhang, Huiyu Yan, Xiaoyu Qu, Wei Zhou
Demethylbellidifolin, a major xanthone compound of Swertia davidi Franch, showed many beneficial pharmacological effects including antioxidation, anti-inflammation, anti-fibrosis, and cardiovascular protection effects. In this research, a rapid and sensitive LC-MS/MS method for the quantitative analysis of demethylbellidifolin in rat plasma was developed. The demethylbellidifolin and internal standard of aurantio-obtusin were extracted from 50 μL of rat plasma samples with ethyl acetate, then the dried residue was reconstituted and injected in an HPLC system with ZORBAX SB-C18 analytical column (2...
July 5, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28674220/isolation-and-characterization-of-microsatellite-markers-in-garcinia-gummi-gutta-by-next-generation-sequencing-and-cross-species-amplification
#18
K V Ravishankar, R Vasudeva, Byatroy Hemanth, B S Sandya, B R Sthapit, V A Parthasarathy, V Ramanatha Rao
Garcinia gummi-gutta (L.) Roxb. (Clusiaceae) is an endemic, semidomesticated, fruit-yielding tree species distributed in the Western Ghats of India and Sri Lanka. Various bioactive phytochemicals, such as garcinol, benzophenones and xanthones are isolated from G. gummi-gutta and have shown antibacterial, antiviral and antioxidant activities. We sequenced the total genomic DNA using Illumina Hiseq 2000 platform and examined 241,141,804 bp high quality data, assembled into 773,889 contigs. In these contigs, 27,313 simple-sequence repeats (SSRs) were identified, among which mononucleotide repeats were predominant (44...
June 2017: Journal of Genetics
https://www.readbyqxmd.com/read/28666227/comprehensive-profiling-and-characterization-of-chemical-constituents-of-rhizome-of-anemarrhena-asphodeloides-bge
#19
De Ji, Zi-Yan Huang, Cheng-Hao Fei, Wei-Wei Xue, Tu-Lin Lu
The rhizome of Anemarrhena asphodeloides Bge. is commonly used as an herbal medicine in China. In this study, ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS) was used, in both negative and positive ion modes, to comprehensively analyze the chemical constituents of A. asphodeloides. From the intact precursor ions, MS/MS fragmentation information, and previous reports, we identified 89 compounds. These compounds included 8 cyclic peptides, 11 flavones (9 xanthones), 45 steroidal saponins, 15 fatty acids, 3 lignans, and 7 other compounds...
August 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28665538/%C3%AE-glucosidase-inhibitory-xanthones-from-the-roots-of-garcinia-fusca
#20
Nam K Nguyen, Xuyen A Truong, Thai Q Bui, Dzung N Bui, Hai X Nguyen, Phuong T Tran, Lien-Hoa D Nguyen
An ethyl acetate extract of the roots of Garcinia fusca produced two new compounds, fuscaxanthones J (1) and K (2), together with eight known xanthones (3-10). Their structures were determined using spectroscopic methods, mainly 1-D and 2-D NMR. α-Glucosidase inhibitory activity of the isolated compounds was evaluated and fuscaxanthone J (1) showed the most significant effect with IC50 value of 8.3 ± 1.8 μM (compared with acarbose, IC50 = 214.5 ± 2.3 μM). This article is protected by copyright. All rights reserved...
June 30, 2017: Chemistry & Biodiversity
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