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https://www.readbyqxmd.com/read/28163970/garcinia-subelliptica-merr-fukugi-a-multipurpose-coastal-tree-with-promising-medicinal-properties
#1
REVIEW
Tomomi Inoue, Mami Kainuma, Karin Baba, Nozomi Oshiro, Norimi Kimura, Eric Wei Chiang Chan
In this short review, the current knowledge on the botany, ecology, uses, and medicinal properties of the multipurpose Garcinia subelliptica (Fukugi) is updated. As yet, there are no reviews on this indigenous and heritage coastal tree species of the Ryukyu Islands in Japan, which has ethnocultural, ecological, and pharmacological significance. Planted by the Okinawan people some 300 years ago, Fukugi trees serve as windbreaks and accord protection against the destructive typhoons. The species has become a popular ornamental tree, and its bark has been used for dyeing fabrics...
January 2017: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/28108382/new-xanthones-and-cytotoxic-constituents-from-garcinia-mangostana-fruit-hulls-against-human-hepatocellular-breast-and-colorectal-cancer-cell-lines
#2
Gamal A Mohamed, Ahmed M Al-Abd, Ali M El-Halawany, Hossam M Abdallah, Sabrin R M Ibrahim
ETHNOPHARMACOLOGICAL RELEVANCE: Cancer has proceeded to surpass one of the most chronic illnesses to be the major cause of mortality in both the developing and developed world. Garcinia mangostana L. (mangosteen, family Guttiferae) known as the queen of fruits, is one of the most popular tropical fruits. It is cultivated in Southeast Asian countries: Malaysia, Indonesia, Sri Lanka, Burma, Thailand, and Philippines. Traditionally, numerous parts of G. mangostana have been utilized to treat various ailments such as abdominal pain, haemorrhoids, food allergies, arthritis, leucorrhoea, gonorrhea, diarrhea, dysentery, wound infection, suppuration, and chronic ulcer...
January 17, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28017996/extraction-of-anthocyanins-from-pericarp-and-lipids-from-seeds-of-mangosteen-garcinia-mangostana-l-by-ultrasound-assisted-extraction-uae-and-evaluation-of-pericarp-extract-enriched-functional-ice-cream
#3
Lawan Hiranrangsee, Kishore K Kumaree, Muhammad Bilal Sadiq, Anil K Anal
Ultrasound-assisted extraction (UAE) was used to extract the anthocyanins from pericarp and lipids from the seeds of mangosteen. The optimum time for extraction of anthocyanin by maceration method and shaking water bath was 6 and 4 h, respectively, whereas, it was 5 min only for ultrasonic assisted extraction method. The anthocyanin content, extracted by UAE, was 23.54 mg Cyn-3-Glu/100 g. The regression equation derived by response surface methodology (RSM), was used to predict the anthocyanin content extracted by using UAE...
October 2016: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/27933873/amelioration-of-experimental-autoimmune-encephalomyelitis-by-isogarcinol-extracted-from-garcinia-mangostana-l-mangosteen
#4
Mengqi Wang, Yufei Xie, Youxiu Zhong, Juren Cen, Lei Wang, Yuanyuan Liu, Ying Zhu, Li Tong, Qun Wei
Isogarcinol is a new natural immunosuppressant that was extracted from Garcinia mangostana L. in our laboratory. Knowledge of its effects on treatable diseases and its mechanism of action is still very limited. In this study, we explored the therapeutic effect of isogarcinol in experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS). Treatment with oral 100 mg/kg isogarcinol markedly ameliorated clinical scores, alleviated inflammation and demyelination of the spinal cord, and reduced intracranial lesions in EAE mice...
November 30, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27824406/anticarcinogenic-effects-of-%C3%AE-mangostin-a-review
#5
Kuo-Jun Zhang, Qin-Lan Gu, Kan Yang, Xian-Jun Ming, Jin-Xin Wang
Cancer chemoprevention is a promising strategy taken to block, reverse, or retard carcinogenesis. α-Mangostin, a natural xanthone isolated from the pericarps of mangosteen, represents one of the most studied chemopreventive agents. This compound has been reported to interfere with all the major stages of carcinogenesis: initiation, promotion, and progression. A number of mechanisms have been proposed for its anticarcinogenic activities. This review summarizes the current knowledge on the mechanisms that contribute to the observed activity of α-mangostin related to (i) modulation of carcinogenic biotransformation and mitigation of oxidative damage, (ii) induction of growth arrest and apoptosis, (iii) suppression of angiogenesis and metastasis, and (iv) combination with clinical chemotherapy drugs enhancing their efficacy and decreasing the toxic side effects...
February 2017: Planta Medica
https://www.readbyqxmd.com/read/27748172/herb-drug-interactions-an-insight-into-cardiovascular-diseases-based-on-case-reports
#6
Maria Campos, C Batista, N R Jesus, C M Silva, T P Silva
Cardiovascular patients frequently use herbal medicinal products, in order to contribute to the improvement of their chronic condition without medical intervention. However, they are likely to suffer from adverse effects from natural products and herb-drug interactions. This work aimed to alert cardiovascular patients and healthcare providers of the potential of occurrence of herb-drug interactions with cardiovascular therapy. Information obtained from the campaign "Aprender Saúde Entre as Plantas e os Medicamentos", carried out by the Observatory of Herb-Drug Interactions (www...
October 7, 2016: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/27703599/antioxidant-enhancing-property-of-the-polar-fraction-of-mangosteen-pericarp-extract-and-evaluation-of-its-safety-in-humans
#7
Wichit Suthammarak, Pornpayom Numpraphrut, Ratiya Charoensakdi, Neelobol Neungton, Vachara Tunrungruangtavee, Nattapon Jaisupa, Suwit Charoensak, Primchanien Moongkarndi, Weerasak Muangpaisan
Crude extract from the pericarp of the mangosteen (mangosteen extract [ME]) has exhibited several medicinal properties in both animal models and human cell lines. Interestingly, the cytotoxic activities were always observed in nonpolar fraction of the extract whereas the potent antioxidant was often found in polar fraction. Although it has been demonstrated that the polar fraction of ME exhibited the antioxidant activity, the safety of the polar fraction of ME has never been thoroughly investigated in humans...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27673663/neuroprotective-and-memory-enhancing-effects-of-the-water-extract-from-pericarp-of-mangosteen-fruit
#8
J Cho, Y-W Chin
No abstract text is available yet for this article.
October 6, 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/27668185/de-novo-transcriptome-assembly-of-mangosteen-garcinia-mangostana-l-fruit
#9
Deden Derajat Matra, Toshinori Kozaki, Kazuo Ishii, Roedhy Poerwanto, Eiichi Inoue
Garcinia mangostana L. (Mangosteen), of the family Clusiaceae, is one of the economically important tropical fruits in Indonesia. In the present study, we performed de novo transcriptomic analysis of Garcinia mangostana L. through RNA-Seq technology. We obtained the raw data from 12 libraries through Ion Proton System. Clean reads of 191,735,809 were obtained from 307,634,890 raw reads. The raw data obtained in this study can be accessible in DDBJ database with accession number of DRA005014 with bioproject accession number of PRJDB5091...
December 2016: Genomics Data
https://www.readbyqxmd.com/read/27584012/%C3%AE-mangostin-extraction-from-the-native-mangosteen-garcinia-mangostana-l-and-the-binding-mechanisms-of-%C3%AE-mangostin-to-hsa-or-trf
#10
Ming Guo, Xiaomeng Wang, Xiaowang Lu, Hongzheng Wang, Peter E Brodelius
In order to obtain the biological active compound, α-mangostin, from the traditional native mangosteen (Garcinia mangostana L.), an extraction method for industrial application was explored. A high yield of α-mangostin (5.2%) was obtained by extraction from dried mangosteen pericarps with subsequent purification on macroporous resin HPD-400. The chemical structure of α-mangostin was verified mass spectrometry (MS), nuclear magnetic resonance (1H NMR and 13C NMR), infrared spectroscopy (IR) and UV-Vis spectroscopy...
2016: PloS One
https://www.readbyqxmd.com/read/27566110/synergism-and-the-mechanism-of-action-of-the-combination-of-%C3%AE-mangostin-isolated-from-garcinia-mangostana-l-and-oxacillin-against-an-oxacillin-resistant-staphylococcus-saprophyticus
#11
Sineewan Phitaktim, Mullika Chomnawang, Kittipot Sirichaiwetchakoon, Benjawan Dunkhunthod, Glyn Hobbs, Griangsak Eumkeb
BACKGROUND: Globally, staphylococci have developed resistance to many antibiotics. New approaches to chemotherapy are needed and one such approach could be to use plant derived actives with conventional antibiotics in a synergestic way. The purpose of this study was to isolate α-mangostin from the mangosteen (Garcinia mangostana L.; GML) and investigate antibacterial activity and mechanisms of action when used singly and when combined with oxacillin against oxacillin-resistant Staphylococcus saprophyticus (ORSS) strains...
2016: BMC Microbiology
https://www.readbyqxmd.com/read/27561254/nitric-oxide-inhibitory-xanthones-from-the-pericarps-of-garcinia-mangostana
#12
Qianyu Liu, Dan Li, Anqi Wang, Zhen Dong, Sheng Yin, Qingwen Zhang, Yang Ye, Liangchun Li, Ligen Lin
Mangosteen (Garcinia mangostana, Clusiaceae) is called "queen of fruit" in Southeast Asia. In the current study, three dimeric xanthones, garcinoxanthones A-C, and four monomeric xanthones, garcinoxanthones D-G, together with 18 known xanthones, were isolated from the pericarps of G. mangostana, collected in Thailand. The structures of garcinoxanthones A-G were elucidated by analysis of their 1D and 2D NMR and other spectroscopic data, and their absolute configurations were determined by the CD spectra. All seven compounds were tested for nitric oxide (NO) inhibitory activity on lipopolysaccharide (LPS)-stimulated RAW264...
November 2016: Phytochemistry
https://www.readbyqxmd.com/read/27491646/gartanin-induces-cell-cycle-arrest-and-autophagy-and-suppresses-migration-involving-pi3k-akt-mtor-and-mapk-signalling-pathway-in-human-glioma-cells
#13
Ming Luo, Qingyu Liu, Mingliang He, Zhiling Yu, Rongbiao Pi, Min Li, Xiaohong Yang, Shengnan Wang, Anmin Liu
In central nervous system, glioma is the most common primary brain tumour. The diffuse migration and rapid proliferation are main obstacles for successful treatment. Gartanin, a natural xanthone of mangosteen, suppressed proliferation, migration and colony formation in a time- and concentration-dependent manner in T98G glioma cells but not in mouse normal neuronal HT22 cells. Gartanin, at low micromole, led to cell cycle arrest in G1 phase accompanied by inhibited expression level of G1 cell cycle regulatory proteins cyclin D1, while increased expression level of cyclin-dependent kinase inhibitor p27Kip1...
January 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27478478/%C3%AE-mangostin-induces-apoptosis-and-cell-cycle-arrest-in-oral-squamous-cell-carcinoma-cell
#14
Hyun-Ho Kwak, In-Ryoung Kim, Hye-Jin Kim, Bong-Soo Park, Su-Bin Yu
Mangosteen has long been used as a traditional medicine and is known to have antibacterial, antioxidant, and anticancer effects. Although the effects of α-mangostin, a natural compound extracted from the pericarp of mangosteen, have been investigated in many studies, there is limited data on the effects of the compound in human oral squamous cell carcinoma (OSCC). In this study, α-mangostin was assessed as a potential anticancer agent against human OSCC cells. α-Mangostin inhibited cell proliferation and induced cell death in OSCC cells in a dose- and time-dependent manner with little to no effect on normal human PDLF cells...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27276843/xanthones-isolated-from-the-pericarp-of-mangosteen-inhibit-neurotransmitter-receptors-expressed-in-xenopus-oocytes
#15
Pathama Leewanich, Sunit Suksamram
OBJECTIVE: This study aimed to evaluate inhibitory effects of 7 xanthones and 3 extracts obtained from the pericarp of mangosteen on serotonin (5-HT), N-methyl-D-aspartate (NMDA) and glycine receptors expressed in Xenopus oocytes. MATERIAL AND METHOD: Xenopus oocytes were injected with RNA of either 5-HT NMDA or glycine receptor and inhibitory effects of the xanthones and extracts were investigated using the two-electrode voltage clamp technique. RESULTS: Xanthones from the pericarp of mangosteen affected 5-HT NMDA and glycine receptor functions with different degree of inhibition...
November 2015: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
https://www.readbyqxmd.com/read/27276829/effects-of-long-term-alpha-mangostin-supplementation-on-hyperglycemia-and-insulin-resistance-in-type-2-diabetic-rats-induced-by-high-fat-diet-and-low-dose-streptozotocin
#16
Chantana Mekseepralard, Chonticha Areebambud, Sunit Suksamrarn, Amporn Jariyapongskul
OBJECTIVE: The present study investigated the effects of long-term supplementation of alpha-mangostin (MG; a xanthone isolated from mangosteen fruit) on hyperglycemia, and insulin resistance in type 2 diabetic rats. MATERIAL AND METHOD: Type 2 diabetes (DM2) was induced in male Sprague-Dawley rats by feeding high fat diet for three weeks followed by an IP injection of low dose streptozotocin. The rats were divided into four groups: control and diabetes without or with alpha-MG supplementation (CON, DM2, CON-MG and DM2-MG group, respectively)...
November 2015: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
https://www.readbyqxmd.com/read/27246698/current-trends-of-tropical-fruit-waste-utilization
#17
Choon Yoong Cheok, Noranizan Mohd Adzahan, Russly Abdul Rahman, Nur Hanani Zainal Abedin, Norhayati Hussain, Rabiha Sulaiman, Gun Hean Chong
Recent rapid growth of the world's population has increased food demands. This phenomenon poses a great challenge for food manufacturers in maximizing the existing food or plant resources. Nowadays, the recovery of health benefit bioactive compounds from fruit wastes is a research trend not only to help minimize the waste burden, but also to meet the intensive demand from the public for phenolic compounds which are believed to have protective effects against chronic diseases. This review is focused on polyphenolic compounds recovery from tropical fruit wastes and its current trend of utilization...
May 31, 2016: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/27185538/food-safety-in-thailand-3-pesticide-residues-detected-in-mangosteen-garcinia-mangostana-l-queen-of-fruits
#18
Kamonrat Phopin, Sompon Wanwimolruk, Virapong Prachayasittikul
BACKGROUND: For developing countries like Thailand, regulation of pesticide usage exists, but it is not fully enforced. Therefore, pesticide residues in vegetables and fruits have not been well monitored. This study aimed to determine the pesticide residues in mangosteen fruits sold in Thailand. The mangosteen samples (n = 111) were purchased and the contents of 28 pesticides were analysed by GC-MS/MS method. RESULTS: Of the pesticides tested, eight were found in 100% of the mangosteen samples...
February 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27177723/garcinone-d-a-natural-xanthone-promotes-c17-2-neural-stem-cell-proliferation-possible-involvement-of-stat3-cyclin-d1-pathway-and-nrf2-ho-1-pathway
#19
Xiaohong Yang, Shengnan Wang, Ying Ouyang, Yaling Tu, Anmin Liu, Yinghong Tian, Mingliang He, Rongbiao Pi
Garcinia mangostana L. (Mangosteen) has been used to treat various pathological conditions, including inflammation and urinary tract infections. Here, we observed that garcinone D, a natural xanthone from mangosteen, promoted the proliferation of C17.2 neural progenitor cells and also resulted in a larger percentage of cells in S phase compared with the control group. Moreover, garcinone D increased the protein levels of phosphorylated signal transducer and activator of transcription 3 (p-STAT3) and Cyclin D1 in concentration- and time- dependent manners...
July 28, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27161377/gartanin-protects-neurons-against-glutamate-induced-cell-death-in-ht22-cells-independence-of-nrf-2-but-involvement-of-ho-1-and-ampk
#20
Xiao-Yun Gao, Sheng-Nan Wang, Xiao-Hong Yang, Wen-Jian Lan, Zi-Wei Chen, Jing-Kao Chen, Jian-Hui Xie, Yi-Fan Han, Rong-Biao Pi, Xiao-Bo Yang
Oxidative stress mediates the pathogenesis of neurodegenerative disorders. Gartanin, a natural xanthone of mangosteen, possesses multipharmacological activities. Herein, the neuroprotection capacity of gartanin against glutamate-induced damage in HT22 cells and its possible mechanism(s) were investigated for the first time. Glutamate resulted in cell death in a dose-dependent manner and supplementation of 1-10 µM gartanin prevented the detrimental effects of glutamate on cell survival. Additional investigations on the underlying mechanisms suggested that gartanin could effectively reduce glutamate-induced intracellular ROS generation and mitochondrial depolarization...
September 2016: Neurochemical Research
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