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https://www.readbyqxmd.com/read/28936043/the-potential-of-mangosteen-garcinia-mangostana-peel-extract-combined-with-demineralized-freeze-dried-bovine-bone-xenograft-to-reduce-ridge-resorption-and-alveolar-bone-regeneration-in-preserving-the-tooth-extraction-socket
#1
Utari Kresnoadi, Maretaningtias Dwi Ariani, Eha Djulaeha, Nike Hendrijantini
BACKGROUND: Following the extraction of a tooth, bone resorption can cause significant problems for a subsequent denture implant and restorative dentistry. Thus, the tooth extraction socket needs to be maintained to reduce the chance of any alveolar ridge bone resorption. OBJECTIVE: The objective of this study is to determine whether the administration of mangosteen peel extracts (MPEs), combined with demineralized freeze-dried bovine bone xenograft (DFBBX) materials for tooth extraction socket preservation, could potentially reduce inflammation by decreased the expression of nuclear factor κβ (NfKb) and receptor activator of nuclear factor-κβ ligand (RANKL), to inhibit alveolar bone resorption, and increased of bone morphogenetic protein-2 (BMP2) expressions to accelerate alveolar bone regeneration...
July 2017: Journal of Indian Prosthodontic Society
https://www.readbyqxmd.com/read/28924329/a-computational-tool-for-accelerated-analysis-of-oligomeric-proanthocyanidins-in-plants
#2
Mengliang Zhang, Jianghao Sun, Pei Chen
A computational tool was developed to facilitate proanthocyanidin analysis using data collected by ultra-high-performance liquid chromatography-diode array detection-high resolution accurate mass-mass spectrometry (UHPLC-DAD-HRAM-MS). Both identification and semi-quantitation of proanthocyanidins can be achieved by the developed computational tool. It can extract proanthocyanidin chromatographic peaks, deconvolute the isotopic patterns of A-type, B-type, and multi-charged proanthocyanidins ions, and predict proanthocyanidin structures...
March 2017: Journal of Food Composition and Analysis
https://www.readbyqxmd.com/read/28915439/alpha-mangostin-suppresses-interleukin-1%C3%AE-induced-apoptosis-in-rat-chondrocytes-by-inhibiting-the-nf-%C3%AE%C2%BAb-signaling-pathway-and-delays-the-progression-of-osteoarthritis-in-a-rat-model
#3
Tianlong Pan, Rong Chen, Dengying Wu, Ningyu Cai, Xuchao Shi, Bin Li, Jun Pan
Osteoarthritis (OA) is a chronic degenerative joint disease that is characterized by progressive joint dysfunction and pain. Apoptosis and catabolism in chondrocytes play critical roles in the development of OA. Alpha-Mangostin (α-MG), one of the main components of the mangosteen, has been reported to have anti-apoptotic, anti-inflammatory and antioxidant effects. We investigated the therapeutic effects of α-MG on OA through experiments on rat chondrocytes in vitro and in a rat model of OA induced by destabilization of the medial meniscus (DMM)...
September 12, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28878295/garcinone-e-induces-apoptosis-and-inhibits-migration-and-invasion-in-ovarian-cancer-cells
#4
Xiao-Huang Xu, Qian-Yu Liu, Ting Li, Jian-Lin Liu, Xin Chen, Li Huang, Wen-An Qiang, Xiuping Chen, Yitao Wang, Li-Gen Lin, Jin-Jian Lu
Ovarian cancer remains the most lethal gynecological malignant tumor. In this study, 24 xanthones were isolated and identified from the pericarps of mangosteen (Garcinia mangostana), and their anti-proliferative activities were tested in ovarian cancer cells. Garcinone E (GE) was found to exhibit excellent anti-proliferative effects among the tested xanthones. It significantly inhibited the proliferation in HEY, A2780, and A2780/Taxol cells as evidenced by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, lactate dehydrogenase (LDH) release assay, Hoechst 33342 staining, annexin V/PI staining, and JC-1 staining...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28864423/alpha-mangostin-inhibits-both-dengue-virus-production-and-cytokine-chemokine-expression
#5
Mayuri Tarasuk, Pucharee Songprakhon, Pattamawan Chimma, Panudda Sratongno, Kesara Na-Bangchang, Pa-Thai Yenchitsomanus
Since severe dengue virus (DENV) infection in humans associates with both high viral load and massive cytokine production - referred to as "cytokine storm", an ideal drug for treatment of DENV infection should efficiently inhibit both virus production and cytokine expression. In searching for such an ideal drug, we discovered that α-mangostin (α-MG), a major bioactive compound purified from the pericarp of the mangosteen fruit (Garcinia mangostana Linn), which has been used in traditional medicine for several conditions including trauma, diarrhea, wound infection, pain, fever, and convulsion, inhibits both DENV production in cultured hepatocellular carcinoma HepG2 and Huh-7 cells, and cytokine/chemokine expression in HepG2 cells...
August 31, 2017: Virus Research
https://www.readbyqxmd.com/read/28842267/medicinal-properties-of-mangosteen-garcinia-mangostana-l-a-comprehensive-update
#6
REVIEW
Berenice Ovalle-Magallanes, Dianelena Eugenio-Pérez, José Pedraza-Chaverri
Garcinia mangostana L. (Clusiaceae) is a tropical tree native to Southeast Asia known as mangosteen which fruits possess a distinctive and pleasant taste that has granted them the epithet of "queen of the fruits". The seeds and pericarps of the fruit have a long history of use in the traditional medicinal practices of the region, and beverages containing mangosteen pulp and pericarps are sold worldwide as nutritional supplements. The main phytochemicals present in the species are isoprenylated xanthones, a class of secondary metabolites with multiple reports of biological effects, such as antioxidant, pro-apoptotic, anti-proliferative, antinociceptive, anti-inflammatory, neuroprotective, hypoglycemic and anti-obesity...
August 24, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28757558/the-bionomics-of-the-cocoa-mealybug-exallomochlus-hispidus-morrison-hemiptera-pseudococcidae-on-mangosteen-fruit-and-three-alternative-hosts
#7
Murni Indarwatmi, Dadang Dadang, Sobir Ridwani, Endang Sri Ratna
The cocoa mealybug, Exallomochlus hispidus Morrison (Hemiptera: Pseudococcidae) is known to attack mangosteen, an important fruit export commodity for Indonesia. The mealybug is polyphagous, so alternative host plants can serve as a source of nourishment. This study aimed to record the bionomics of E. hispidus on mangosteen (Garcinia mangostana L.) and three alternative hosts, kabocha squash (Cucurbita maxima L.), soursop (Annona muricata, L.), and guava (Psidium guajava L.). First-instar nymphs of the E. hispidus were reared at room temperature on mangosteen, kabocha, soursop, and guava fruits until they developed into adults and produced nymphs...
July 25, 2017: Insects
https://www.readbyqxmd.com/read/28698459/dietary-natural-products-for-prevention-and-treatment-of-breast-cancer
#8
REVIEW
Ya Li, Sha Li, Xiao Meng, Ren-You Gan, Jiao-Jiao Zhang, Hua-Bin Li
Breast cancer is the most common cancer among females worldwide. Several epidemiological studies suggested the inverse correlation between the intake of vegetables and fruits and the incidence of breast cancer. Substantial experimental studies indicated that many dietary natural products could affect the development and progression of breast cancer, such as soy, pomegranate, mangosteen, citrus fruits, apple, grape, mango, cruciferous vegetables, ginger, garlic, black cumin, edible macro-fungi, and cereals. Their anti-breast cancer effects involve various mechanisms of action, such as downregulating ER-α expression and activity, inhibiting proliferation, migration, metastasis and angiogenesis of breast tumor cells, inducing apoptosis and cell cycle arrest, and sensitizing breast tumor cells to radiotherapy and chemotherapy...
July 8, 2017: Nutrients
https://www.readbyqxmd.com/read/28656594/review-of-garcinia-mangostana-and-its-xanthones-in-metabolic-syndrome-and-related-complications
#9
REVIEW
Hourieh Tousian Shandiz, Bibi Marjan Razavi, Hossein Hosseinzadeh
Metabolic syndrome is coexistence of abdominal obesity, hyperglycemia, hyperlipidemia and hypertension that causes cardiovascular diseases, diabetes and their complications, low quality and short lifespan. Garcinia mangostana and its xanthones such as α-mangostin have been shown desirable effects such as anti-obesity, anti-hyperglycemic, anti-dyslipidemia, anti-diabetic and antiinflammatory effects in experimental studies. Various databases such as PubMed, Scopus and Web of Science with keywords of 'Garcinia mangostana', 'mangosteen', 'α-mangostin', 'metabolic syndrome', 'hypoglycemic', 'antihyperglicemic', 'antidiabetic', 'hypotensive', 'antihypertensive', 'atherosclerosis', 'arteriosclerosis' and 'hyperlipidemia' have been investigated in this search without publication time limitation...
August 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28654307/mangosteen-extract-prevents-dextran-sulfate-sodium-induced-colitis-in-mice-by-suppressing-nf-%C3%AE%C2%BAb-activation-and-inflammation
#10
Hee-Sung Chae, Byoung Hoon You, Jieun Song, Hyuk Wan Ko, Young Hee Choi, Young-Won Chin
In this study, the anti-inflammatory effects of mangosteen extract (MGE) on dextran sulfate sodium (DSS)-induced colitis in mice and nuclear factor (NF)-κB pathway modulation were investigated. Acute colitis was induced by administering 3% DSS in drinking water for 7 days, and three groups of Institute of Cancer Research mice were treated with 30 and 120 mg/kg MGE or 5-aminosalicylic acid for 7 days; an additional two groups of mice served as healthy and disease controls. The results indicated that MGE significantly prevented weight loss, reduced disease activity index scores, and preserved colon length compared with the findings in the untreated colitis group...
August 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28641010/alpha-mangostin-reverses-multidrug-resistance-by-attenuating-the-function-of-the-multidrug-resistance-linked-abcg2-transporter
#11
Chung-Pu Wu, Sung-Han Hsiao, Megumi Murakami, Yu-Jen Lu, Yan-Qing Li, Yang-Hui Huang, Tai-Ho Hung, Suresh V Ambudkar, Yu-Shan Wu
The ATP-binding cassette (ABC) drug transporter ABCG2 can actively efflux a wide variety of chemotherapeutic agents out of cancer cells and subsequently reduce the intracellular accumulation of these drugs. Therefore, the overexpression of ABCG2 often contributes to the development of multidrug resistance (MDR) in cancer cells, which is one of the major obstacles to successful cancer chemotherapy. Moreover, ABCG2 is highly expressed in various tissues including the intestine and blood-brain barrier (BBB), limiting the absorption and bioavailability of many therapeutic agents...
August 7, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28582759/%C3%AE-mangostin-inhibits-dmba-tpa-induced-skin-cancer-through-inhibiting-inflammation-and-promoting-autophagy-and-apoptosis-by-regulating-pi3k-akt-mtor-signaling-pathway-in-mice
#12
Fei Wang, Hongxia Ma, Zhaoguo Liu, Wei Huang, Xiaojing Xu, Xuemei Zhang
Skin cancer is the most common form of cancer responsible for considerable morbidity and mortality, the treatment progress of which remains slow though. Therefore, studies identifying anti-skin cancer agents that are innocuous are urgently needed. α-Mangostin, a natural product isolated from the pericarp of mangosteen fruit, has potent anti-cancer activity. However, its role in skin cancer remains unclear. The aim of this study was to evaluate the treatment effect of α-mangostin on skin tumorigenesis induced by 9,10-dimethylbenz[a]anthracene (DMBA)/TPA in mice and the potential mechanism...
August 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28573253/in-vivo-carbon-tetrachloride-induced-hepatoprotective-and-in-vitro-cytotoxic-activities-of-garcinia-hombroniana-seashore-mangosteen
#13
Nargis Jamila, Naeem Khan, Amir Atlas Khan, Imran Khan, Sadiq Noor Khan, Zainal Amiruddin Zakaria, Melati Khairuddean, Hasnah Osman, Kyong Su Kim
BACKGROUND: Garcinia hombroniana, known as "manggis hutan" (jungle mangosteen) in Malaysia, is distributed in tropical Asia, Borneo, Thailand, Andaman, Nicobar Islands, Vietnam and India. In Malaysia, its ripened crimson sour fruit rind is used as a seasoning agent in curries and culinary dishes. Its roots and leaves decoction is used against skin infections and after child birth. This study aimed to evaluate in vivo hepatoprotective and in vitro cytotoxic activities of 20% methanolic ethyl acetate (MEA) G...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28560167/rna-seq-analysis-of-mangosteen-garcinia-mangostana-l-fruit-ripening
#14
Azhani Abdul-Rahman, Hoe-Han Goh, Kok-Keong Loke, Normah Mohd Noor, Wan Mohd Aizat
Mangosteen (Garcinia mangostana L.) is known for its delectable taste and contains high amount of xanthones which have been reported to possess anti-cancer, anti-inflammatory and other bioactive properties. However, stage-specific regulation of mangosteen fruit ripening has never been studied in detail. We have performed a comparative transcriptomic analysis of three ripening stages (Stage 0, 2 and 6) of mangosteen. We have obtained a raw data from six libraries through Illumina HiSeq 4000. A total of ~ 40 Gb of raw data were generated...
June 2017: Genomics Data
https://www.readbyqxmd.com/read/28529883/smrt-sequencing-data-for-garcinia-mangostana-l-variety-mesta
#15
Mohd Razik Midin, Kok-Keong Loke, Maria Madon, Mohd Shukor Nordin, Hoe-Han Goh, Normah Mohd Noor
The "Queen of Fruits" mangosteen (Garcinia mangostana L.) produces commercially important fruits with desirable taste of flesh and pericarp rich in xanthones with medicinal properties. To date, only limited knowledge is available on the cytogenetics and genome sequences of a common variety of mangosteen (Abu Bakar et al., 2016 [1]). Here, we report the first single-molecule real-time (SMRT) sequencing data from whole genome sequencing of mangosteen of Mesta variety. Raw reads of the SMRT sequencing project can be obtained from SRA database with the accession numbers SRX2718652 until SRX2718659...
June 2017: Genomics Data
https://www.readbyqxmd.com/read/28516035/dna-shotgun-sequencing-analysis-of-garcinia-mangostana-l-variety-mesta
#16
Syuhaidah Abu Bakar, Suresh Kumar, Kok-Keong Loke, Hoe-Han Goh, Normah Mohd Noor
Mangosteen (Garcinia mangostana Linn.) is an ultra-tropical tree characterized by its unique dark purple fruits with white flesh. The xanthone-rich purple pericarp tissue contains valuable compounds with medicinal properties. Following previously reported genome sequencing of a common variety of mangosteen [1], we performed another whole genome sequencing of a commercially popular variety of this fruit species (var. Mesta) for comparative analysis of its genome composition. Raw reads of the DNA sequencing project were deposited to SRA database with the accession number SRX2709728...
June 2017: Genomics Data
https://www.readbyqxmd.com/read/28441346/xanthones-from-the-pericarp-of-garcinia-mangostana
#17
Renyue Yang, Ping Li, Nana Li, Qian Zhang, Xue Bai, Lishuo Wang, Yiying Xiao, Lirong Sun, Quan Yang, Jian Yan
Mangosteen (Garcinia mangostana L.) is one of the most popular tropical fruits (called the "Queen of Fruits"), and is a rich source of oxygenated and prenylated xanthone derivatives. In the present work, phytochemical investigation has resulted in one new prenylated xanthone and 13 known xanthones isolated from the pericarp of G. mangostana. Their structures were established by spectroscopic data analysis, including X-ray diffraction. The new one was further tested for cytotoxic activity against seven cancer cell lines (CNE-1, CNE-2, A549, H490, PC-3, SGC-7901, U87), displaying the half maximal inhibitory concentration (IC₅0) values 3...
April 25, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28284429/pharmacology-of-mangostins-and-their-derivatives-a-comprehensive-review
#18
REVIEW
Ming-Hui Wang, Kuo-Jun Zhang, Qin-Lan Gu, Xiao-Ling Bi, Jin-Xin Wang
Mangosteen (Garcinia mangostana Linn.) is a well-known tropical tree indigenous to Southeast Asia. Its fruit's pericarp abounds with a class of isoprenylated xanthones which are referred as mangostins. Numerous in vitro and in vivo studies have shown that mangostins and their derivatives possess diverse pharmacological activities, such as antibacterial, antifungal, antimalarial, anticarcinogenic, antiatherogenic activities as well as neuroprotective properties in Alzheimer's disease (AD). This review article provides a comprehensive review of the pharmacological activities of mangostins and their derivatives to reveal their promising utilities in the treatment of certain important diseases, mainly focusing on the discussions of the underlying molecular targets/pathways, modes of action, and relevant structure-activity relationships (SARs)...
February 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28274037/antimicrobial-effects-of-garcinia-mangostana-on-cariogenic-microorganisms
#19
Sunitha Janardhanan, Jaideep Mahendra, A S Smiline Girija, Little Mahendra, Vijayashree Priyadharsini
INTRODUCTION: Garcinia mangostana commonly called as Mangosteen fruit has been used as an antibacterial agent since age old times. The mangosteen pericarp has proven to have antibacterial effect, but the effect of the same on cariogenic organisms has not been explored. The present study was an attempt to gain a better understanding of the antibacterial effect of mangosteen pericarp on the cariogenic bacteria, to unravel the therapeutic potential for the same. AIM: The aim of the study was to assess the antibacterial efficacy of the crude chloroform extract of mangosteen pericarp against cariogenic bacteria...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28254113/development-and-in%C3%A2-vivo-evaluation-of-self-microemulsion-as-delivery-system-for-%C3%AE-mangostin
#20
Wen-Ke Xu, Hui Jiang, Kui Yang, Ya-Qin Wang, Qian Zhang, Jian Zuo
α-Mangostin (MG) is a versatile bioactive compound isolated from mangosteen and possesses significant pharmacokinetic shortages. To augment the potential clinical efficacy, MG-loaded self-microemulsion (MG-SME) was designed and prepared in this study, and its potential as a drug loading system was evaluated based on the pharmacokinetic performance and tissue distribution feature. The formula of MG-SME was optimized by an orthogonal test under the guidance of ternary phase diagram, and the prepared MG-SME was characterized by encapsulation efficiency, size distribution, and morphology...
March 2017: Kaohsiung Journal of Medical Sciences
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