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Multidrug resistant gram negative bacteria

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https://www.readbyqxmd.com/read/28453272/bacterial-iron-uptake-pathways-gates-for-the-import-of-bactericide-compounds
#1
Isabelle J Schalk, Gaëtan L A Mislin
Bacterial resistance to most antibiotics in clinical use has reached alarming proportions. A challenge for modern medicine will be to discover new antibiotics or strategies to combat multidrug resistant bacteria, especially Gram-negative bacteria for which the situation is particularly critical. Vectorization of bactericide compounds by siderophores (iron chelators produced by bacteria) is a promising strategy able to considerably increase the efficacy of drugs. Such a Trojan horse strategy can also extend activity of specific Gram-positive antibiotics to Gram-negative bacteria...
April 28, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28447330/seawater-drowning-associated-pneumonia-a-10-year-descriptive-cohort-in-intensive-care-unit
#2
Alexandre Robert, Pierre-Éric Danin, Hervé Quintard, Nicolas Degand, Nihal Martis, Denis Doyen, Céline Pulcini, Raymond Ruimy, Carole Ichai, Gilles Bernardin, Jean Dellamonica
BACKGROUND: Pneumonia is one of the major complications of drowning, but the optimal empirical antibiotic treatment is not clearly defined. Multidrug-resistant (MDR) bacteria and fungi have been identified in a recent series of freshwater drowning-associated pneumonia. However, microbial data in seawater drowning are scarce. The objective of the study is to describe the microorganisms isolated in early respiratory specimens obtained from seawater drowning-associated pneumonia and to provide their antibiotic susceptibility pattern...
December 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28444620/environmental-pollution-with-antimicrobial-agents-from-bulk-drug-manufacturing-industries-in-hyderabad-south-india-is-associated-with-dissemination-of-extended-spectrum-beta-lactamase-and-carbapenemase-producing-pathogens
#3
Christoph Lübbert, Christian Baars, Anil Dayakar, Norman Lippmann, Arne C Rodloff, Martina Kinzig, Fritz Sörgel
PURPOSE: High antibiotic and antifungal concentrations in wastewater from anti-infective drug production may exert selection pressure for multidrug-resistant (MDR) pathogens. We investigated the environmental presence of active pharmaceutical ingredients and their association with MDR Gram-negative bacteria in Hyderabad, South India, a major production area for the global bulk drug market. METHODS: From Nov 19 to 28, 2016, water samples were collected from the direct environment of bulk drug manufacturing facilities, the vicinity of two sewage treatment plants, the Musi River, and habitats in Hyderabad and nearby villages...
April 26, 2017: Infection
https://www.readbyqxmd.com/read/28443385/pseudomonas-aeruginosa-prevalence-antibiotic-resistance-and-antimicrobial-use-in-chinese-burn-wards-from-2007-to-2014
#4
Yi Dou, Jingning Huan, Feng Guo, Zengding Zhou, Yan Shi
Objective To assess the application of antibacterial agents, alongside pathogen prevalence and Pseudomonas aeruginosa drug resistance, with the aim of understanding the impact of inappropriate antibacterial use. Methods This retrospective study assessed bacteria from wounds, catheters, blood, faeces, urine and sputum of hospitalized patients in burn wards between 2007 and 2014. The intensity of use of antibacterial agents and resistance of P. aeruginosa to common anti-Gram-negative antibiotics were measured...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28437232/epidemiological-physiological-and-molecular-characteristics-of-a-brazilian-collection-of-carbapenem-resistant-acinetobacter-baumannii-and-pseudomonas-aeruginosa
#5
Vanessa Cordeiro Dias, Juliana Alves Resende, André Netto Bastos, Lucas Quinet De Andrade Bastos, Victor Quinet De Andrade Bastos, Ricardo Villela Bastos, Cláudio Galuppo Diniz, Vânia Lúcia Da Silva
Nonfermenting Gram-negative bacteria such as Pseudomonas aeruginosa and Acinetobacter baumannii are widespread in the environment and are increasingly associated with nosocomial infections, often associated with multidrug-resistance phenotypes. This study aimed to evaluate epidemiological, physiological, and molecular characteristics of carbapenem resistance in P. aeruginosa and A. baumannii. In total, 63 nonreplicated strains (44 A. baumannii and 19 P. aeruginosa) were isolated from hospitalized patients. Antimicrobial resistance patterns, biocide tolerance, oxidative stress, hemolytic activity, and biofilm formation were assessed...
February 24, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28426936/cholesterol-assisted-bacterial-cell-surface-engineering-for-photodynamic-inactivation-of-gram-positive-and-gram-negative-bacteria
#6
Hao-Ran Jia, Ya-Xuan Zhu, Zhan Chen, Fu-Gen Wu
Antibacterial photodynamic therapy (PDT) which enables effective killing of regular and multidrug-resistant (MDR) bacteria is a promising treatment modality for bacterial infection. However, because most photosensitizer (PS) molecules fail to strongly interact with the surface of Gram-negative bacteria, this technique is only suitable for treating Gram-positive bacterial infection, which largely hampers its practical applications. Herein, we revealed for the first time that cholesterol could significantly facilitate the hydrophobic binding of PSs to the bacterial surface, achieving the hydrophobic interaction-based bacterial cell surface engineering that could effectively photo-inactivate both Gram-negative and Gram-positive bacteria...
April 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28418298/esbl-and-carbapenemase-producing-enterobacteriaceae-in-patients-with-bacteremia-yangon-myanmar-2014
#7
Tin O Myat, Rachel F Hannaway, Khwar N Zin, Wah W Htike, Kyu K Win, John A Crump, David R Murdoch, James E Ussher
Among 42 gram-negative bloodstream isolates from inpatients in 3 hospitals in Yangon, Myanmar, admitted during July-December 2014, 16 (38%) were extended-spectrum β-lactamase-producing Enterobacteriaceae and 6 (14%) produced carbapenemase. The high prevalence of multidrug-resistant gram-negative bacteria raises concerns about the empiric treatment of patients with sepsis in Yangon.
May 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28411476/trimethyl-chitosan-capped-silver-nanoparticles-with-positive-surface-charge-their-catalytic-activity-and-antibacterial-spectrum-including-multidrug-resistant-strains-of-acinetobacter-baumannii
#8
T Y Chang, C C Chen, K M Cheng, C Y Chin, Y H Chen, X A Chen, J R Sun, J J Young, T S Chiueh
We report a facile route for the green synthesis of trimethyl chitosan nitrate-capped silver nanoparticles (TMCN-AgNPs) with positive surface charge. In this synthesis, silver nitrate, glucose, and trimethyl chitosan nitrate (TMCN) were used as silver precursor, reducing agent, and stabilizer, respectively. The reaction was carried out in a stirred basic aqueous medium at room temperature without the use of energy-consuming or expensive equipment. We investigated the effects of the concentrations of NaOH, glucose, and TMCN on the particle size, zeta potential, and formation yield...
April 1, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28410932/outcome-analysis-of-colistin-treated-burn-center-patients
#9
Rachel E Wilkinson, David M Hill, William L Hickerson
OBJECTIVES: Intravenous colistimethate sodium (CMS) use in burn center patients is increasing due to the emergence of multidrug-resistant gram-negative bacteria. However, optimal dosing strategies and factors that may contribute to treatment failure are limited. The purpose of this study was to determine factors that may contribute to treatment failure in colistin-treated burn center patients. METHODS: This retrospective, observational study included burn center patients that received ≥48h of intravenous CMS between June 1, 2009 and June 30, 2014...
April 11, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28409644/amphiphilic-tobramycin-lysine-conjugates-sensitize-multidrug-resistant-gram-negative-bacteria-to-rifampicin-and-minocycline
#10
Yinfeng Lyu, Xuan Yang, Sudeep Goswami, Bala Kishan Gorityala, Temilolu Idowu, Ronald Domalaon, George G Zhanel, Anshan Shan, Frank Schweizer
Chromosomally encoded low membrane permeability and highly efficient efflux systems are major mechanisms by which Pseudomonas aeruginosa evades antibiotic actions. Our previous reports have shown that amphiphilic tobramycin-fluoroquinolone hybrids can enhance efficacy of fluoroquinolone antibiotics against multidrug-resistant (MDR) P. aeruginosa isolates. Herein, we report on a novel class of tobramycin-lysine conjugates containing an optimized amphiphilic tobramycin-C12 tether that sensitize Gram-negative bacteria to legacy antibiotics...
April 24, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28406949/antimicrobial-resistant-infections-among-postpartum-women-at-a-ugandan-referral-hospital
#11
Lisa M Bebell, Joseph Ngonzi, Joel Bazira, Yarine Fajardo, Adeline A Boatin, Mark J Siedner, Ingrid V Bassett, Dan Nyehangane, Deborah Nanjebe, Yves Jacquemyn, Jean-Pierre van Geertruyden, Juliet Mwanga-Amumpaire, David R Bangsberg, Laura E Riley, Yap Boum
INTRODUCTION: Puerperal sepsis causes 10% of maternal deaths in Africa, but prospective studies on incidence, microbiology and antimicrobial resistance are lacking. METHODS: We performed a prospective cohort study of 4,231 Ugandan women presenting to a regional referral hospital for delivery or postpartum care, measured vital signs after delivery, performed structured physical exam, symptom questionnaire, and microbiologic evaluation of febrile and hypothermic women...
2017: PloS One
https://www.readbyqxmd.com/read/28403894/antibiotic-resistant-airborne-bacteria-and-their-multidrug-resistance-pattern-at-university-teaching-referral-hospital-in-south-ethiopia
#12
Fithamlak Bisetegen Solomon, Fiseha Wada Wadilo, Amsalu Amache Arota, Yishak Leka Abraham
BACKGROUND: Hospitals provide a reservoir of microorganisms, many of which are multi-resistant to antibiotics. Emergence of multi-drug resistant strains in a hospital environment, particularly in developing countries is an increasing problem to infection treatment. This study aims at assessing antibiotic resistant airborne bacterial isolates. METHODS: A cross-sectional study was conducted at Wolaita Sodo university teaching and referral Hospital. Indoor air samples were collected by using passive air sampling method...
April 12, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28399372/a-tobramycin-vector-enhances-synergy-and-efficacy-of-efflux-pump-inhibitors-against-multidrug-resistant-gram-negative-bacteria
#13
Xuan Yang, Sudeep Goswami, Bala Kishan Gorityala, Ronald Domalaon, Yinfeng Lyu, Ayush Kumar, George G Zhanel, Frank Schweizer
Drug efflux mechanisms interact synergistically with the outer membrane permeability barrier of Gram-negative bacteria, leading to intrinsic resistance that presents a major challenge for antibiotic drug development. Efflux pump inhibitors (EPIs) which block the efflux of antibiotics synergize antibiotics, but the clinical development of EPI/antibiotic combination therapy to treat multidrug-resistant (MDR) Gram-negative infections has been challenging. This is in part caused by the inefficiency of current EPIs to penetrate the outer membrane and resist efflux...
April 24, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28396656/prescription-patterns-for-tigecycline-in-severely-ill-patients-for-non-fda-approved-indications-in-a-developing-country-a-compromised-outcome
#14
Rima A Moghnieh, Dania I Abdallah, Ismail A Fawaz, Tarek Hamandi, Mohammad Kassem, Nabila El-Rajab, Tamima Jisr, Anas Mugharbil, Nabila Droubi, Samaa Al Tabah, Loubna Sinno, Fouad Ziade, Ziad Daoud, Ahmad Ibrahim
Introduction: With the rise in antibiotic resistance, tigecycline has been used frequently in off-label indications, based on its in-vitro activity against multidrug-resistant organisms. In this study, our aim was to assess its use in approved and unapproved indications. Materials and Methods: This is a retrospective chart review evaluating a 2-year experience of tigecycline use for > 72 h in 153 adult patients inside and outside critical care unit from January 2012 to December 2013 in a Lebanese tertiary-care hospital...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28393523/nanotransformation-of-vancomycin-overcomes-the-intrinsic-resistance-of-gram-negative-bacteria
#15
Margarida M Fernandes, Kristina Ivanova, Javier Hoyo, Sílvia Pérez-Rafael, Antonio Francesko, Tzanko Tzanov
The increased emergence of antibiotic-resistant bacteria is a growing public health concern, and although new drugs are constantly being sought, the pace of development is slow compared with the evolution and spread of multidrug-resistant species. In this study, we developed a novel broad-spectrum antimicrobial agent by simply transforming vancomycin into nanoform using sonochemistry. Vancomycin is a glycopeptide antibiotic largely used for the treatment of infections caused by Gram-positive bacteria but inefficient against Gram-negative species...
April 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28390975/natural-isothiocyanates-express-antimicrobial-activity-against-developing-and-mature-biofilms-of-pseudomonas-aeruginosa
#16
Stefan J Kaiser, Nico T Mutters, Brigitte Blessing, Frank Günther
BACKGROUND: The antimicrobial properties of natural isothiocyanates (ITCs) found in plants such as nasturtium (Tropaeolum majus) and horseradish (Armoracia rusticana), and the need of new chemotherapeutic options for treatment of infections caused by multidrug-resistant and biofilm-forming Gram-negative bacteria such as Pseudomonas aeruginosa (Pa), led us to evaluate the effects of three major ITCs, allylisothiocyanate (AITC), benzylisothiocyanate (BITC), and phenylethyl-isothiocyanate (PEITC), and a mixture (ITCM) adapted to the ITC composition after release of active components out of natural sources...
April 5, 2017: Fitoterapia
https://www.readbyqxmd.com/read/28390963/targeting-biofilms-of-multidrug-resistant-bacteria-with-silver-oxynitrate
#17
Lindsay R Kalan, Deanna M Pepin, Imran Ul-Haq, Steve B Miller, Michelle E Hay, Rod Precht
A topical antimicrobial, silver oxynitrate (Ag7NO11), has recently become available that exploits the antimicrobial activity of ionic silver but has enhanced activity because highly oxidised silver atoms are stabilised with oxygen in a unique chemical formulation. The objective of this study was to use a multifaceted approach to characterise the spectrum of antimicrobial and antibiofilm activity of a wound dressing coated with Ag7NO11 at a concentration of 0.4 mg Ag/cm(2). Physiochemical properties that influence efficacy were also evaluated, and Ag7NO11 was found to release a high level of Ag ions, including Ag(2+) and Ag(3+), without influencing the pH of the medium...
April 5, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28386474/finding-novel-antibiotic-substances-from-medicinal-plants-antimicrobial-properties-of-nigella-sativa-directed-against-multidrug-resistant-bacteria
#18
Seher Nancy Bakal, Stefan Bereswill, Markus M Heimesaat
The progressive rise in multidrug-resistant (MDR) bacterial strains poses serious problems in the treatment of infectious diseases. While the number of newly developed antimicrobial compounds has greatly fallen, the resistance of pathogens against commonly prescribed drugs is further increasing. This rise in resistance illustrates the need for developing novel therapeutic and preventive antimicrobial options. The medicinal herb Nigella sativa and its derivatives constitute promising candidates. In a comprehensive literature survey (using the PubMed data base), we searched for publications on the antimicrobial effects of N...
March 2017: European Journal of Microbiology & Immunology
https://www.readbyqxmd.com/read/28385464/microbiology-of-surgical-site-infections-in-patients-with-cancer-a-7-year-review
#19
Juan Carlos Hernaiz-Leonardo, Maria Fernanda Golzarri, Patricia Cornejo-Juárez, Patricia Volkow, Consuelo Velázquez, Mauricio Ostrosky-Frid, Diana Vilar-Compte
BACKGROUND: Health care-associated infections (HAIs) have arisen as major sources of multidrug-resistant bacteria. Surgical site infections (SSIs) are the most frequent HAIs in many countries, with high antimicrobial-resistant prevalence. METHODS: A 7-year retrospective review (2008-2014) of microbiologic data within a prospective surveillance program on patients with SSI at a cancer hospital in Mexico. RESULTS: There were 23,421 surgeries performed during the study period...
April 3, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28374901/the-impact-of-carbapenem-resistance-on-clinical-deterioration-and-mortality-in-patients-with-liver-disease
#20
Philip G Ferstl, Natalie Filmann, Christian Brandt, Stefan Zeuzem, Michael Hogardt, Volkhard A J Kempf, Mona Müller, Oliver Waidmann, Claudia Reinheimer
BACKGROUND & AIMS: Infections with multidrug-resistant gram-negative bacteria are significantly impairing the prognosis of patients with liver disease. In particular, carbapenem resistance further narrows therapeutic options. This study investigates the impact of carbapenem-resistant gram-negative bacteria on the outcome of patients with liver disease and cirrhosis. METHODS: Between January 2011 and July 2015, 132 patients treated at the tertiary liver transplant center at University Hospital Frankfurt, Germany, were tested positive for carbapenem-resistant gram-negative bacteria and retrospectively analyzed in this study...
April 4, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
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