keyword
https://read.qxmd.com/read/38484344/mortality-in-patients-with-hematological-malignancies-febrile-neutropenia-and-septic-shock
#21
JOURNAL ARTICLE
Beda Islas-Muñoz, Patricia Volkow-Fernández, Jorge Silva-Zamora, Ana Ramírez-Ibarguen, Patricia Cornejo-Juárez
INTRODUCTION: Patients with severe neutropenia who develop septic shock (SS) have high mortality. This study aimed to evaluate the risk factors and mortality of SS in patients with HM and febrile neutropenia. METHODOLOGY: We included all patients with hematological malignancies (HM) who presented fever and severe neutropenia, admitted to an oncological tertiary care center in Mexico City for one year. RESULTS: Two hundred ninety-two episodes of fever and severe neutropenia were documented; 68 patients (23...
February 29, 2024: Journal of Infection in Developing Countries
https://read.qxmd.com/read/38483783/pseudomembranous-colitis-and-parabacteroides-distasonis-bacteraemia-a-rare-clinical-presentation
#22
JOURNAL ARTICLE
Catherine Hsu, Claudia Moore-Gillon, Mathew Vithayathil, Shwan Karim
We present the case of a male with end-stage diabetic nephropathy on haemodialysis who initially presented with acute-on-chronic digital ulceration. While awaiting vascular intervention, he became septic with abdominal pain and diarrhoea. Flexible sigmoidoscopy confirmed pseudomembranous colitis secondary to Clostridium difficile. Blood cultures grew Parabacteroides distasonis, a Gram-negative gut anaerobe. Enterobacter cloacae, another Gram-negative anaerobic gut bacilli, was grown in colonic cultures and swabs of the digital ulcers...
March 14, 2024: Clinical Journal of Gastroenterology
https://read.qxmd.com/read/38483683/characterization-and-genome-informatic-analysis-of-a-novel-lytic-mendocina-phage-vb_pmes_stp12-suitable-for-phage-therapy-pseudomonas-or-biocontrol
#23
JOURNAL ARTICLE
Sani Sharif Usman, Evangeline Christina
BACKGROUND: A novel lytic bacteriophage (phage) was isolated with Pseudomonas mendocina strain STP12 (P. mendocina) from the untreated site of Sewage Treatment Plant of Lovely Professional University, India. P. mendocina is a Gram-negative, rod-shaped, aerobic bacterium belonging to the family Pseudomonadaceae and has been reported in fifteen (15) cases of economically important diseases worldwide. METHODS AND RESULTS: Here, a novel phage specifically infecting and killing P...
March 14, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38483625/challenges-and-mitigation-strategies-associated-with-burkholderia-cepacia-complex-contamination-in-pharmaceutical-manufacturing
#24
REVIEW
Sethuraman Prem Kumar, Karupanagounder Thangaraj Uthra, Vellapandian Chitra, Narayanasamy Damodharan, Gururaja Perumal Pazhani
Burkholderia cepacia complex (BCC) is a Gram-negative, non-spore-forming bacterium with more than 20 opportunistic pathogenic species, most commonly found in soil and water. Due to their rapid mutation rates, these organisms are adaptable and possess high genomic plasticity. BCC can cause life-threatening infections in immunocompromised individuals, such as those with cystic fibrosis, chronic granulomatous disease, and neonates. BCC contamination is a significant concern in pharmaceutical manufacturing, frequently causing non-sterile product recalls...
March 14, 2024: Archives of Microbiology
https://read.qxmd.com/read/38483476/complete-sequence-of-carbapenem-resistant-ralstonia-mannitolilytica-clinical-isolate-co-producing-novel-class-d-%C3%AE-lactamase-oxa-1176-and-oxa-1177-in-japan
#25
JOURNAL ARTICLE
Wataru Hayashi, Hiroyuki Kaiju, Shizuo Kayama, Liansheng Yu, Hui Zuo, Yo Sugawara, Kaoru Azuma, Akemi Takahashi, Yuka Hata, Motoyuki Sugai
In 2020, the Ralstonia mannitolilytica strain JARB-RN-0044 was isolated from a midstream urine sample of an elderly hospitalized patient in Japan and was highly resistant to carbapenem (i.e., imipenem, meropenem, and doripenem). Whole-genome sequencing revealed that the complete genome consists of two replicons, a 3.5-Mb chromosome and a 1.5-Mb large non-chromosomal replicon which has not been reported in R. mannitolilytica, and referred to as the "megaplasmid" in this study based on Cluster of Orthologous Group of proteins functional analysis...
March 14, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38483177/exploring-the-antibacterial-activity-and-cellular-fates-of-enterobactin-drug-conjugates-that-target-gram-negative-bacterial-pathogens
#26
JOURNAL ARTICLE
Chuchu Guo, Elizabeth M Nolan
ConspectusSiderophores are secondary metabolites utilized by bacteria to acquire iron (Fe), an essential transition metal nutrient. Fe levels in the host environment are tightly regulated and can be further restricted to starve invading bacterial pathogens in a host-defense process known as nutritional immunity. To survive and colonize the Fe-limited host environment, bacteria produce siderophores and express cognate siderophore transport machinery. These active transport pathways present an opportunity for selective and efficient drug delivery into bacterial cells, motivating decades of research on synthetic siderophore-antibiotic conjugates (SACs) as a Trojan-horse strategy for the development of targeted antibiotics...
March 14, 2024: Accounts of Chemical Research
https://read.qxmd.com/read/38483164/-in-vitro-activity-of-cefiderocol-against-european-pseudomonas-aeruginosa-and-acinetobacter-spp-including-isolates-resistant-to-meropenem-and-recent-%C3%AE-lactam-%C3%AE-lactamase-inhibitor-combinations
#27
JOURNAL ARTICLE
Anne Santerre Henriksen, Katy Jeannot, Antonio Oliver, John D Perry, Mathias W Pletz, Stefania Stefani, Ian Morrissey, Christopher Longshaw
UNLABELLED: Carbapenem-resistant Pseudomonas aeruginosa and Acinetobacter spp. represent major threats and have few approved therapeutic options. Non-‍fermenting Gram-negative isolates were collected from hospitalized inpatients from 49 sites in 6 European countries between 01 January 2020 and 31 December 2020 and underwent susceptibility testing against cefiderocol and β-lactam/β-lactamase inhibitor combinations. Meropenem-resistant (MIC >8 mg/L), cefiderocol-susceptible isolates were analyzed by PCR, and cefiderocol-resistant isolates were analyzed by whole-genome sequencing to identify resistance mechanisms...
March 14, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38483146/-porphyromonas-gingivalis-induced-hematogenous-disseminated-severe-pneumonia-a-case-report
#28
JOURNAL ARTICLE
Zhou Yuanjun, Cai Yan, Zhang Qingyan, Xiong Feng
Porphyromonas gingivalis , a gram-negative oral anaerobe among more than more than 500 bacterial species that colonizing the oral cavity, is involved in the pathogenesis and prototypic polybacterial consortium of periodontitis. It is mainly found in oral infections and rarely present in other organ diseases. Here, we describe a 43-year-old man with underlying diabetes who developed hematogenous disseminated severe pneumonia after P. gingivalis had invaded the blood. Next-generation sequencing of early alveolar lavage fluid and blood samples confirmed the diagnosis...
March 2024: Journal of International Medical Research
https://read.qxmd.com/read/38482364/genotypic-characterization-of-bacterial-isolates-causing-urinary-tract-infections-among-adults-at-kiambu-level-5-hospital-kenya-selected-extended-spectrum-%C3%AE-lactamase-genes-and-biofilm-formation
#29
JOURNAL ARTICLE
Fredrick K Wanja, Eric O Omwenga, Caroline W Ngugi, John N Maina, John N Kiiru
The menace of antimicrobial resistance affecting public health is rising globally. Many pathogenic bacteria use mechanisms such as mutations and biofilm formation, significantly reducing the efficacy of antimicrobial agents. In this cross-sectional study, we aimed to determine the prevalence of selected extended-spectrum β-lactamase (ESβL) genes and analyse the biofilm formation abilities of the isolated bacteria causing urinary tract infection among adult patients seeking Medicare at Kiambu Level 5 Hospital, Kenya...
2024: Access microbiology
https://read.qxmd.com/read/38482272/spectrum-of-pathogens-and-their-antimicrobial-susceptibility-pattern-isolated-from-bronchoalveolar-lavage-specimens-at-a-hilly-area-in-uttarakhand
#30
JOURNAL ARTICLE
Nidhi Negi, Pankaj Rawat, Iva Chandola, Uneza Husain, Ketan Priyadarshi
BACKGROUND: Lower respiratory tract infections (LRTIs) are associated with significant morbidity and mortality in all age groups, especially young children and the elderly population. Various gram-positive and gram-negative organisms such as Streptococcus spp., Pseudomonas spp., and Klebsiella spp. have been implicated as a pathogen in bronchoalveolar lavage (BAL) specimens collected from such patients. AIMS AND RATIONALE OF THE STUDY: The present study is aimed at assessing the spectrum of the bacterial isolates and determining the antimicrobial resistance obtained from the BAL fluid from admitted patients at various wards and intensive care units (ICUs) of a tertiary care hospital in Dehradun...
January 2024: Journal of Family Medicine and Primary Care
https://read.qxmd.com/read/38481174/gram-negative-bacterial-colonizations-before-bilateral-lung-transplant-the-impact-of-targeted-versus-standard-surgical-prophylaxis
#31
JOURNAL ARTICLE
Sabrina Congedi, Arianna Peralta, Luisa Muraro, Martina Biscaro, Tommaso Pettenuzzo, Nicolò Sella, Silvia Crociani, Arméla Anne-Sabine Tagne, Ida Caregnato, Francesco Monteleone, Elisa Rossi, Gabriella Roca, Silvia Manfrin, Serena Marinello, Maria Mazzitelli, Andrea Dell'Amore, Annamaria Cattelan, Federico Rea, Paolo Navalesi, Annalisa Boscolo
BACKGROUND: Infections are one of the most common causes of death after lung transplant (LT). However, the benefit of 'targeted' prophylaxis in LT recipients pre-colonized by Gram-negative (GN) bacteria is still unclear. METHODS: All consecutive bilateral LT recipients admitted to the Intensive Care Unit of the University Hospital of Padua (February 2016-2023) were retrospectively screened. Only patients with pre-existing GN bacterial isolations were enrolled and analyzed according to the antimicrobial surgical prophylaxis ('standard' vs...
March 13, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/38481054/scalable-and-versatile-metal-ion-solidificated-alginate-hydrogel-for-skin-wound-infection-therapy
#32
JOURNAL ARTICLE
By Haomiao Zhang, Ye Lu, Lei Huang, Ping Liu, Jun Ni, Tianqi Yang, Yihong Li, Yu Zhong, Xinping He, Xinhui Xia, Jiancang Zhou
Bacterial infections in wounds continue to be a major challenge in clinical settings worldwide and represent a significant threat to human health. In this work, we have proposed novel expandable and versatile methods for solidifying sodium alginate (SA) with metal ions (such as Fe3+ , Co2+ , Ni2+ , Cu2+ , and Zn2+ ) to create Metal-Alginate (M-Alg) hydrogel with adjustable morphology, composition, and microstructure. It conforms to the wound site, protects against second infection, reduces inflammation, and promotes the healing of infected wounds...
March 13, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38479922/a-case-report-of-lactobacillus-bacteremia-in-a-patient-on-chronic-parenteral-nutrition
#33
JOURNAL ARTICLE
Hannah W Fiske, Breton Roussel, Marion Winkler, Benjamin Hall
BACKGROUND AND AIMS: Short bowel syndrome is a malabsorption disorder typically caused by the physical loss of a portion of the intestine, whereafter the body is unable to adequately absorb nutrients, fluids, and electrolytes. Many patients with short bowel syndrome are reliant on home parenteral nutrition through a tunneled or peripherally inserted central catheter to ensure sufficient hydration and nutrition. Central venous catheters are a nidus for bacteria, and patients are at risk for infections associated with high levels of morbidity and mortality...
April 2024: Clinical Nutrition ESPEN
https://read.qxmd.com/read/38478274/in-vivo-disulfide-bond-crosslinking-to-study-%C3%AE-barrel-membrane-protein-interactions-dynamicity-and-folding-intermediates
#34
JOURNAL ARTICLE
Matthew Thomas Doyle
Membrane-embedded β-barrels are the major building blocks of the Gram-negative outer membrane and are involved in antibiotic resistance, virulence, and the maintenance of bacterial cell physiology. The increased frequency of multidrug resistant Gram-negative infections warrants the sharing of accessible methods for the study of β-barrels. One such method is "in vivo disulfide-bond crosslinking" which is a highly informative and cost-effective approach to study the structure, topology, dynamicity, and function of β-barrels in situ...
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38477004/study-of-colistin-resistant-gram-negative-organism-in-hospitalized-patients-a-retrospective-study
#35
JOURNAL ARTICLE
Dnyaneshwar Diwane, Prasad A Rajhans, Sameer A Jog, Mousami Dalvi
BACKGROUND: Intensive care units have become hotspots for antimicrobial resistance, particularly concerning colistin resistance, posing a threat of untreatable infections. AIM: This study aims to analyze the epidemiological and clinical aspects of patients carrying colistin-resistant organisms. It focuses on identifying risk factors, the microbiological profile, susceptibility patterns, and treatment outcomes. MATERIALS AND METHODS: Isolates with colistin MIC >2 µg/mL, identified via BD PHOENIX, were subjected to colistin broth disc elution testing (as per CLSI guidelines) in our Microbiology Department between January and December 2022...
March 2024: Indian Journal of Critical Care Medicine
https://read.qxmd.com/read/38476774/defining-the-pharmacokinetic-pharmacodynamic-index-of-piperacillin-tazobactam-within-a-hollow-fibre-infection-model-to-determine-target-attainment-in-intensive-care-patients
#36
JOURNAL ARTICLE
Suzanne A M Wenker, Najla Alabdulkarim, John B Readman, Elise M A Slob, Giovanni Satta, Shanom Ali, Nishma Gadher, Rob Shulman, Joseph F Standing
BACKGROUND: It is important to optimize dosing schemes of antibiotics to maximize the probability of therapeutic success. The recommended pharmacokinetic/pharmacodynamic (PK/PD) index for piperacillin/tazobactam therapy in clinical studies ranges widely (50%-100% fT >1-4×MIC ). Dosing schemes failing to achieve PK/PD targets may lead to negative treatment outcomes. OBJECTIVES: The first aim of this study was to define the optimal PK/PD index of piperacillin/tazobactam with a hollow-fibre infection model (HFIM)...
April 2024: JAC-antimicrobial resistance
https://read.qxmd.com/read/38476736/infective-endocarditis-due-to-citrobacter-koseri-following-testicular-trauma-case-report-and-literature-review
#37
Julian Orlando Casallas-Barrera, Claudia Marcela Poveda-Henao, Karen Andrea Mantilla-Viviescas, Edwin Silva-Monsalve
Infective endocarditis (IE) is a condition with low prevalence but high mortality rates within intensive care units. Microbiologically, most cases are attributed to Gram-positive cocci, while Gram-negative bacilli are less commonly involved. This case report describes a patient with IE caused by Citrobacter koseri (C. koseri) with secondary bacteremia due to blunt testicular trauma and epididymitis. We conducted a review of the literature to assess the clinical and associated risk factors of this underreported condition...
2024: Therapeutic Advances in Infectious Disease
https://read.qxmd.com/read/38474038/bactericidal-efficacy-of-the-combination-of-maresin-like-proresolving-mediators-and-carbenicillin-action-on-biofilm-forming-burn-trauma-infection-related-bacteria
#38
JOURNAL ARTICLE
Anbu Mozhi Thamizhchelvan, Abdul-Razak Masoud, Shanchun Su, Yan Lu, Hongying Peng, Yuichi Kobayashi, Yu Wang, Nathan K Archer, Song Hong
Biofilm-associated bacterial infections are the major reason for treatment failure in many diseases including burn trauma infections. Uncontrolled inflammation induced by bacteria leads to materiality, tissue damage, and chronic diseases. Specialized proresolving mediators (SPMs), including maresin-like lipid mediators (MarLs), are enzymatically biosynthesized from omega-3 essential long-chain polyunsaturated fatty acids, especially docosahexaenoic acid (DHA), by macrophages and other leukocytes. SPMs exhibit strong inflammation-resolving activities, especially inflammation provoked by bacterial infection...
February 28, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38474006/deciphering-the-interrelationship-of-arnt-involved-in-lipid-a-alteration-with-the-virulence-of-salmonella-typhimurium
#39
JOURNAL ARTICLE
Chandran Sivasankar, Khristine Kaith Sison Lloren, John Hwa Lee
The lipopolysaccharide (LPS) that resides on the outermost surface and protects Gram-negative bacteria from host defenses is one of the key components leading to Salmonella infection, particularly the endotoxic lipid A domain of LPS. Lipid A modifications have been associated with several genes such as the arnT that encodes 4-amino-4-deoxy-L-arabinose transferase, which can be critical for bacteria to resist cationic antimicrobial peptides and interfere with host immune recognition. However, the association of arnT with virulence is not completely understood...
February 27, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38471985/application-of-a-multiplex-molecular-pneumonia-panel-and-real-world-impact-on-antimicrobial-stewardship-among-patients-with-hospital-acquired-and-ventilator-associated-pneumonia-in-intensive-care-units
#40
JOURNAL ARTICLE
Chieh-Lung Chen, How-Yang Tseng, Wei-Cheng Chen, Shinn-Jye Liang, Chih-Yen Tu, Yu-Chao Lin, Po-Ren Hsueh
BACKGROUND: The optimal timing for applying the BioFire FilmArray Pneumonia Panel (FAPP) in intensive care unit (ICU) patients with hospital-acquired pneumonia (HAP) or ventilator-associated pneumonia (VAP) remains undefined, and there are limited data on its impact on antimicrobial stewardship. METHODS: This retrospective study was conducted at a referral hospital in Taiwan from November 2019 to October 2022. Adult ICU patients with HAP/VAP who underwent FAPP testing were enrolled...
March 6, 2024: Journal of Microbiology Immunology and Infection
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