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https://www.readbyqxmd.com/read/29166668/interleukin-36%C3%AE-and-il-36-receptor-signaling-mediate-impaired-host-immunity-and-lung-injury-in-cytotoxic-pseudomonas-aeruginosa-pulmonary-infection-role-of-prostaglandin-e2
#1
Tetsuji Aoyagi, Michael W Newstead, Xianying Zeng, Yuta Nanjo, Marc Peters-Golden, Mitsuo Kaku, Theodore J Standiford
Pseudomonas aeruginosa is a Gram-negative pathogen that can lead to severe infection associated with lung injury and high mortality. The interleukin (IL)-36 cytokines (IL-36α, IL-36β and IL-36γ) are newly described IL-1 like family cytokines that promote inflammatory response via binding to the IL-36 receptor (IL-36R). Here we investigated the functional role of IL-36 cytokines in the modulating of innate immune response against P. aeruginosa pulmonary infection. The intratracheal administration of flagellated cytotoxic P...
November 22, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29166257/raoultella-planticola-a-rare-cause-of-wound-infection
#2
Shana S Kalaria, Kristina Elliott, Neal Combs, Linda G Phillips
Raoultella planticola is a gram-negative, aerobic, rod bacterium commonly found in the environment, particularly in water, soil, and fish. This organism has been found to cause a variety of infections, such as necrotizing fasciitis, cystitis, cholecystitis, pancreatitis, hepatic disease, and soft tissue infections. The authors report the case of a 73-year-old-woman who presented with a R planticola wound infection of her left lower extremity after a dog scratch. She was treated successfully with local wound care using dehydrated human amnion/chorion and oral levofloxacin...
November 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29165508/-test-evaluation-and-strategy-proposal-to-detect-and-to-characterize-carbapenemase-producing-gram-negative-bacilli
#3
Constanza Muñoz, Cecilia Zumarán, Tamara González, Aniela Wozniak, Claudia Castillo, Patricia García
INTRODUCTION: The detection of carbapenemase-producing gram negative bacilli is complicated, because there are available multiple options of test. The confirmation of the enzyme by molecular characterization is not available in all laboratories in our country. OBJECTIVE: To propose a fast, efficient and simple strategy to detect and confirm CPB. MATERIALS AND METHODS: 39 CPB isolates and 8 non-producing were used to evaluate the phenotypic test Carba NP, CarbAcineto NP and Blue-Carba, validating the test Xpert® Carba-R, to be used directly with bacterial colonies with conventional PCR...
August 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29164489/antimicrobial-stewardship-opportunities-in-critically-ill-patients-with-gram-negative-lower-respiratory-tract-infections-a-multicenter-cross-sectional-analysis
#4
Kimberly C Claeys, Evan J Zasowski, Trang D Trinh, Abdalhamid M Lagnf, Susan L Davis, Michael J Rybak
INTRODUCTION: Lower respiratory tract infections (LRTIs) are a major cause of morbidity and death. Because of changes in how LRTIs are defined coupled with the increasing prevalence of drug resistance, there is a gap in knowledge regarding the current burden of antimicrobial use for Centers for Disease Control and Prevention (CDC)-defined LRTIs. We describe the infection characteristics, antibiotic consumption, and clinical and economic outcomes of patients with Gram-negative (GN) LRTIs treated in intensive care units (ICUs)...
November 21, 2017: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/29164118/infections-caused-by-antimicrobial-drug-resistant-saprophytic-gram-negative-bacteria-in-the-environment
#5
Eva Raphael, Lee W Riley
Background: Drug-resistance genes found in human bacterial pathogens are increasingly recognized in saprophytic Gram-negative bacteria (GNB) from environmental sources. The clinical implication of such environmental GNBs is unknown. Objectives: We conducted a systematic review to determine how often such saprophytic GNBs cause human infections. Methods: We queried PubMed for articles published in English, Spanish, and French between January 2006 and July 2014 for 20 common environmental saprophytic GNB species, using search terms "infections," "human infections," "hospital infection...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29163644/evaluation-of-amprolium-and-toltrazuril-efficacy-in-controlling-natural-intestinal-rabbit-coccidiosis
#6
A El-Ghoneimy, I El-Shahawy
This trial was undertaken with the objective to evaluate the efficacy of amprolium, toltrazuril and their combination in rabbits naturally infected with Eimeria species (32 × 10(3) ± 4.63 oocysts per gram (OPG) of faeces). Thirty-six rabbits (11 weeks old with average body weight (BW) 2000 ± 75 g), were randomly allocated into six groups (six kits each), namely, negative untreated and was retained as negative control (group 1), infected and kept untreated (group 2), treated with single oral dose of amprolium at 50 mg/kg BW for 5 days (group 3), received toltrazuril at 5 mg/kg BW for 2 days (group 4), treated orally with toltrazuril at 2...
2017: Iranian journal of veterinary research
https://www.readbyqxmd.com/read/29162982/future-directions-and-molecular-basis-of-ventilator-associated-pneumonia
#7
REVIEW
Kubra Aykac, Yasemin Ozsurekci, Sevgen Tanir Basaranoglu
Mechanical ventilation is a lifesaving treatment and has complications such as ventilator associated pneumonia (VAP) that lead to high morbidity and mortality. Moreover VAP is the second most common hospital-acquired infection in pediatric intensive care units. Although it is still not well understood, understanding molecular pathogenesis is essential for preventing and treating pneumonia. A lot of microbes are detected as a causative agent of VAP. The most common isolated VAP pathogens in pediatric patients are Staphylococcus aureus, Pseudomonas aeruginosa, and other gram negative bacteria...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29162546/evaluation-of-probiotic-bacillus-aerius-b81e-isolated-from-healthy-hybrid-catfish-on-growth-disease-resistance-and-innate-immunity-of-pla-mong-pangasius-bocourti
#8
Ratchanu Meidong, Kulwadee Khotchanalekha, Sompong Doolgindachbaporn, Takahiro Nagasawa, Miki Nakao, Kenji Sakai, Saowanit Tongpim
Infectious diseases have been found to be a major cause of mortality in fish hatcheries. Probiotics have been introduced to replace antibiotics commonly used for treatment of bacterial infection in aquaculture. This study was conducted to isolate, screen, and evaluate the probiotic Bacillus spp. for potential use as a feed supplement to enhance fish growth, disease resistance and innate immunity of Pla-mong Pangasius bocourti. Bacillus aerius strain B81e was selectively isolated from the intestine of healthy catfish and chosen based on its probiotic properties both in vitro and in vivo...
November 18, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29162543/identification-expression-analysis-and-antibacterial-activity-of-nk-lysin-from-common-carp-cyprinus-carpio
#9
Gai Ling Wang, Ming Cheng Wang, Ying Li Liu, Qian Zhang, Chuan Feng Li, Pan Ting Liu, En Zhong Li, Pin Nie, Hai Xia Xie
Natural killer lysin (NK-lysin), produced by cytotoxic T lymphocytes and natural killer cells, is a cationic antimicrobial peptide that has a broad antimicrobial spectrum, including bacteria, viruses, and parasites. Nevertheless, the implication of NK-lysin in the protection against bacterial infection is not aware in common carp. In this study, six different NK-lysin genes (nkl1, nkl2, nkl3, nkl4, nkl5 and nkl6) were identified in the common carp genome. Each of the mature peptides of common carp NK-lysin has six well-conserved cysteine residues, and shares a Saposin B domain, characteristic of saposin-like protein (SALIP) family...
November 18, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29162541/a-mini-review-on-immune-role-of-chemokines-and-its-receptors-in-snakehead-murrel-channa-striatus
#10
REVIEW
Prasanth Bhatt, Venkatesh Kumaresan, Rajesh Palanisamy, Gayathri Ravichandran, Kanchana Mala, S M Nurul Amin, Aziz Arshad, Fatimah Md Yusoff, Jesu Arockiaraj
Chemokines are ubiquitous cytokine molecules involved in migration of cells during inflammation and normal physiological processes. Though the study on chemokines in mammalian species like humans have been extensively studied, characterization of chemokines in teleost fishes is still in the early stage. The present review provides an overview of chemokines and its receptors in a teleost fish, Channa striatus. C. striatus is an air breathing freshwater carnivore, which has enormous economic importance. This species is affected by an oomycete fungus, Aphanomyces invadans and a Gram negative bacteria Aeromonas hydrophila is known to cause secondary infection...
November 18, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29161992/stenotrophomonas-maltophilia-causing-blood-stream-infection-in-neonates-and-infants-a-cause-for-concern
#11
Rinku Sah, Shraddha Siwakoti, Ratna Baral, Rupa S Rajbhandari, Basuda Khanal
Stenotrophomonas maltophilia ( S. maltophilia) is an important Gram-negative, non-fermentative, multidrug resistant (MDR) nosocomial organism. We evaluated the isolation of S. maltophilia from the seven blood culture specimens received from the Paediatric Emergency Department (PED) of BP Koirala Institute of Health Sciences (BPKIHS) over the duration of two weeks. The suspicion of a possible outbreak was raised and the hospital infection control team investigated the source and found the hand of one healthcare provider harbouring a similar organism...
January 1, 2017: Tropical Doctor
https://www.readbyqxmd.com/read/29161657/effects-of-local-lipopolysaccharide-administration-on-the-expression-of-toll-like-receptor-4-and-pro-inflammatory-cytokines-in-uterus-and-oviduct-of-rabbit-does
#12
Laura Menchetti, Olimpia Barbato, Iulia Elena Filipescu, Giovanna Traina, Leonardo Leonardi, Angela Polisca, Alessandro Troisi, Gabriella Guelfi, Federica Piro, Gabriele Brecchia
Inflammation of the uterus and oviduct is associated with reduced reproductive performance in humans and domestic animals. Toll-like receptors are expressed in various immune and non-immune cells and play a crucial role in innate immunity. Toll-like receptor - 4 (TLR4) can detect lipopolysaccharide (LPS) from Gram-negative bacteria leading to the secretion of pro-inflammatory cytokines, chemokines, antimicrobial peptides and other inflammatory mediators. To investigate the effects of a local inflammation on the expression levels of TLR4 and pro-inflammatory cytokines, 12 female rabbits received an intracervical infusion with either saline solution endotoxin-free (carrier, 2 mL; n = 6) or LPS (500 μg diluted in 2 mL of saline solution; n = 6)...
November 5, 2017: Theriogenology
https://www.readbyqxmd.com/read/29161306/comparison-of-methods-for-determining-the-effectiveness-of-antibacterial-functionalized-textiles
#13
Hajo Haase, Lisa Jordan, Laura Keitel, Claudia Keil, Boris Mahltig
Antimicrobial functionalization of textiles is important for various applications, such as protection of textile materials from decomposition, generation of more effective wound dressings, and the prevention of infections or malodors resulting from bacterial growth. In order to test the efficacy of new products, their antibacterial activity needs to be evaluated. At present, several different procedures are being used for this purpose, hindering comparisons among different studies. The present paper compares five of these assays using a sample panel of different textiles functionalized with copper (Cu) and silver (Ag) as antibacterial agents, and discusses the suitability of these methods for different analytical requirements...
2017: PloS One
https://www.readbyqxmd.com/read/29159897/identification-and-characterization-of-two-variants-of-the-hfq-srna-chaperone-in-the-fish-pathogen-piscirickettsia-salmonis
#14
S H Marshall, P Flores-Herrera, F A Henríquez, F A Gómez
Small RNA and chaperone proteins form synergistic duos that play pivotal roles in controlling gene expression in bacteria. This is the case for Hfq, a highly pleiotropic pretranslational modulator of general protein expression, which responds to harsh environmental conditions and influences fitness and virulence in a wide range of pathogenic Enterobacteria. Given this relevancy, we evaluated the presence and potential role of Hfq in the fish pathogen Piscirickettsia salmonis, a Gram-negative bacterium that threatens the sustainability of Chilean salmon production...
November 21, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/29159071/first-case-report-of-infection-caused-by-cupriavidus-gilardii-in-a-non-immunocompromised-chinese-patient
#15
Zhen Zhang, Wanyan Deng, Shuling Wang, Lanlan Xu, Ling Yan, Pu Liao
Cupriavidus gilardii was first identified as an aerobic, gram-negative, glucose-nonfermenting rod. C. gilardii has been characterized as an organism with low pathogenicity that causes opportunistic infections and few case reports of infection caused by this organism previously. We encountered the first case of bloodstream infection caused in China by C. gilardii in a 87-year old man without obvious immunodeficiency. The isolate were identified as C. gilardii by 16S rRNA sequencing. The infected patient was treated according to the laboratory's antibiogram of this strain...
2017: IDCases
https://www.readbyqxmd.com/read/29158999/recurrent-primary-suprahepatic-abscess-due-to-providencia-stuartii-a-rare-phenomenon
#16
Kyawzaw Lin, Aung Naing Lin, Sandar Linn, Madhavi Reddy, Anjali Bakshi
Gram-negative urease-producing bacilli, Providencia stuartii (P. stuartii), is reported in urinary tract infections, gastroenteritis, and bacteremia in humans but they rarely present with a hepatic abscess. We present a rare case of a recurrent suprahepatic cyst due to P. stuartii in a 45-year-old female, intravenous ( IV) heroin abuser with chronic hepatitis B and C. A 45-year-old female with 10 days status post right suprahepatic abscess drainage presented with recurrent, right, upper quadrant abdominal pain for one day...
September 16, 2017: Curēus
https://www.readbyqxmd.com/read/29158431/salmonella-typhimurium-alters-the-extracellular-proteome-of-macrophages-and-leads-to-the-production-of-pro-inflammatory-exosomes
#17
Winnie W Hui, Kamil Hercik, Sayali Belsare, Navatha Alugubelly, Beata Clapp, Carlos Rinaldi, Mariola J Edelmann
Salmonella enterica serovar Typhimurium is a Gram-negative bacterium, which can invade and survive within macrophages. Pathogenic Salmonellae induce the secretion of specific cytokines from these phagocytic cells and interfere with the host secretory pathways. In this study, we describe the extracellular proteome of human macrophages infected with S. Typhimurium, followed by analysis of canonical pathways of proteins isolated from the extracellular milieu. We demonstrate that some of the proteins secreted by macrophages upon S...
November 20, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/29158205/a-molting-inhibiting-hormone-like-protein-from-pacific-white-shrimp-litopenaeus-vannamei-is-involved-in-immune-responses
#18
Hongliang Zuo, Jia Yuan, Shengwen Niu, Linwei Yang, Shaoping Weng, Jianguo He, Xiaopeng Xu
The molting-inhibiting hormones (MIHs) from the crustacean hyperglycemic hormone (CHH) family are a group of neuropeptides that are implicated in regulation of molting and reproduction in crustaceans. In this study, a novel protein containing a typical crustacean neuropeptide domain was identified from Litopenaeus vannamei. The protein showed high homology with other shrimp MIHs and was then designated as a MIH-like protein (MIHL). Among the detected tissues, the heart expressed the highest level of MIHL. The expression of MIHL could be significantly up-regulated after infection with white spot syndrome virus (WSSV), gram-negative bacterium Vibro parahaemolyticus and gram-positive bacterium Staphylococcus aureus, indicating that MIHL could be involved in immune responses...
November 17, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29157899/epidemiology-of-diabetic-foot-infections-in-a-reference-tertiary-hospital-in-india
#19
Sanjith Saseedharan, Manisa Sahu, Roonam Chaddha, Edwin Pathrose, Arun Bal, Pallavi Bhalekar, Priyadharshini Sekar, Padma Krishnan
INTRODUCTION: The present study attempts to examine the microbial profile and antibiotic susceptibility of diabetic foot infections in the intensive care unit of a tertiary referral centre for diabetic foot. As part of the study, we also attempted to find the prevalence of blaNDM-like gene among carbapenem-resistant gram negative infections. METHODOLOGY: A prospective study of 261 patients with diabetic foot infections was performed during the period between January 2014 and June 2014...
November 1, 2017: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/29157323/prevalence-and-factors-associated-with-multidrug-resistant-gram-negative-organisms-in-patients-with-spinal-cord-injury
#20
Charlesnika T Evans, Margaret A Fitzpatrick, Makoto M Jones, Stephen P Burns, Linda Poggensee, Swetha Ramanathan, Sherri L LaVela, Nasia Safdar, Katie J Suda
OBJECTIVE Infections caused by multidrug-resistant gram-negative organisms (MDRGNOs) have been increasing every year. The objective of this study was to describe the prevalence of MDRGNOs and factors associated with MDRGNOs in patients with spinal cord injury or disorder (SCI/D). DESIGN Retrospective cohort study. METHODS Department of Veterans Affairs (VA) electronic health record data from 142 VA facilities were evaluated for 19,642 patients with SCI/D. Multivariable cluster-adjusted models were fit to identify factors associated with MDRGNO...
November 21, 2017: Infection Control and Hospital Epidemiology
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