keyword
https://read.qxmd.com/read/38493003/clinical-impact-of-vancomycin-mic-on-outcomes-in-patients-with-coagulase-negative-staphylococcal-bacteremia
#1
JOURNAL ARTICLE
Wade Wheat, Brenda Simiyu, Gabriela Andonie, Lillian Bellfi
PURPOSE: Coagulase-negative staphylococci (CoNS) are Gram-positive organisms that are a known component of normal skin flora and the most common cause of nosocomial bacteremia. For CoNS species, the vancomycin MIC breakpoint for susceptibility set by the Clinical and Laboratory Standards Institute is ≤4 µg/mL. There has been published reports of vancomycin heteroresistance in CoNS with vancomycin MICs of 2 to 4 µg/mL. The aim of this retrospective cohort analysis was to assess the clinical impact of vancomycin MICs <2 µg/mL versus ≥2 µg/mL in adult patients with CoNS bloodstream infections...
March 15, 2024: Clinical Therapeutics
https://read.qxmd.com/read/38492739/evaluation-of-two-commercial-broth-microdilution-systems-for-dalbavancin-susceptibility-testing-of-mrsa-and-other-resistant-gram-positive-cocci
#2
JOURNAL ARTICLE
Ilaria Baccani, Alberto Antonelli, Sara Cuffari, Caterina Ferretti, Tommaso Giani, Gian Maria Rossolini
OBJECTIVES: This study aims to evaluate two commercial broth microdilution (BMD) systems, E1-185-100 (Merlin) and FDANDPF (ThermoFisher) for dalbavancin susceptibility testing in comparison with reference broth microdilution assay. METHODS: Study collection was composed of 200 nonreplicate multidrug-resistant Gram-positive cocci of clinical origin, including 180 methicillin-resistant Staphylococcus aureus, 10 vancomycin resistant enterococci, 7 linezolid resistant Staphylococcus epidermidis, and 3 methicillin-resistant coagulase negative staphylococci...
March 14, 2024: Clinical Microbiology and Infection
https://read.qxmd.com/read/38491938/synthesis-stereochemical-resolution-and-analogue-synthesis-of-variabiline-an-aporphine-alkaloid-that-sensitizes-acinetobacter-baumannii-and-klebsiella-pneumoniae-to-colistin
#3
JOURNAL ARTICLE
Haoting Li, Ansley M Nemeth, Roberta J Melander, Christian Melander
Increasing antimicrobial resistance, coupled with the absence of new antibiotics, has led physicians to rely on colistin, a polymyxin with known nephrotoxicity, as the antibiotic of last resort for the treatment of infections caused by Gram-negative bacteria. One approach to increasing antibiotic efficacy and thereby reducing dosage is the use of small-molecule potentiators that augment antibiotic activity. We recently identified the aporphine alkaloid (±)-variabiline, which lowers the minimum inhibitory concentration of colistin in Acinetobacter baumannii and Klebsiella pneumoniae ...
March 16, 2024: ACS Infectious Diseases
https://read.qxmd.com/read/38490892/bordetella-holmesii-causative-agent-of-pertussis
#4
JOURNAL ARTICLE
Meryem Elgarini, Zakaria Mennane, Mohammed Sobh, Abdearrahmane Hammoumi
Bordetella holmesii is a bacterium recently recognized in 1995. It is a gram-negative coccobacillus that can cause pertussis-like symptoms in humans as well as invasive infections. It is often confused with Bordetella pertussis because routine diagnostic tests for whooping cough are not species-specific. The prevalence of B. holmesii as a cause of pertussis has increased in several countries. Therefore, B. holmesii assays are important for determining the epidemiology of pertussis, for the choice of an effective treatment, and for detecting vaccination failures...
March 14, 2024: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://read.qxmd.com/read/38490574/establishment-and-application-of-recombinase-polymerase-amplification-combined-with-lateral-flow-dipstick-for-detection-of-mcr-1-in-unculture-clinical-samples
#5
JOURNAL ARTICLE
Jun Feng, Zhen Xu, Yuan Zhuang, Jiayuan Luo, Yong Chen, Yitong Wu, Jiayi Fei, Mingxiang Liu, Jiahui Xia, Jing Zhang, Meihua Liu, Xiaohong Xie, Zhengan Yuan, Min Chen
OBJECTIVES: The rapid dissemination of the mcr-1 gene via plasmid-mediated transfer has raised concerns regarding the efficacy of colistin as a last-resort treatment for multidrug-resistant Gram-negative bacterial infections. Current mcr-1 gene detection methods mainly focus on cultured bacterial which suffer from complexity, time-consuming process, and skilled personnel requirements, making them unsuitable for field analysis. METHODS: A rapid detection technique combining recombinase polymerase amplification (RPA) with lateral flow dipstick (LFD) targeting on uncultured clinical samples was developed...
March 13, 2024: International Journal of Antimicrobial Agents
https://read.qxmd.com/read/38489813/the-identification-of-risk-factors-and-outcomes-of-cerebrospinal-fluid-shunt-infections-caused-by-carbapenem-resistant-gram-negative-bacteria-in-children-a-retrospective-cohort
#6
JOURNAL ARTICLE
Gizem Guner Ozenen, Zumrut Sahbudak Bal, Elif Bolat, Zuhal Umit, Nimet M Bilen, Sema Yildirim Arslan, Tuncer Turhan, Feriha Cilli, Zafer Kurugol
OBJECTIVE: Cerebrospinal fluid (CSF) shunt infections caused by gram-negative bacteria are difficult to treat given the limited treatment options and the emergence of carbapenem-resistant (CR) strains. This study aimed to evaluate the demographic and clinical characteristics of children with CSF shunt and external ventricular drain (EVD) infections caused by gram-negative bacteria, to identify the risk factors for acquiring CR CSF shunt infections, and to report on the clinical outcomes of these infections...
March 15, 2024: Journal of Neurosurgery. Pediatrics
https://read.qxmd.com/read/38489475/a-comparative-analysis-of-the-antibacterial-spectrum-of-ultrasmall-manganese-ferrite-nanozymes-with-varied-surface-modifications
#7
JOURNAL ARTICLE
Junhua Han, Yingxian Chen, Xin Xiang, Tingting Wang, Jianzhong Shen, Nan Zhang, Chen Liang, Xiaoli Liu, Xiaowei Ma
Bacterial infectious diseases pose a significant global challenge. However, conventional antibacterial agents exhibit limited therapeutic effectiveness due to the emergence of drug resistance, necessitating the exploration of novel antibacterial strategies. Nanozymes have emerged as a highly promising alternative to antibiotics, owing to their particular catalytic activities against pathogens. Herein, we synthesized ultrasmall-sized MnFe2 O4 nanozymes with different charges (MnFe2 O4 -COOH, MnFe2 O4 -PEG, MnFe2 O4 -NH2 ) and assessed their antibacterial capabilities...
March 15, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38489393/the-bioburden-associated-with-severe-open-tibial-fracture-wounds-at-the-time-of-definitive-closure-or-coverage-the-bioburden-study
#8
JOURNAL ARTICLE
(no author information available yet)
BACKGROUND: Infection is common following high-energy open tibial fractures. Understanding the wound bioburden may be critical to infection risk reduction strategies. This study was designed to identify the bioburden profile of high-energy open tibial fractures at the time of definitive wound closure or coverage and determine the relationship to subsequent deep infection. METHODS: This multicenter prospective study enrolled 646 patients with high-energy open tibial fractures requiring a second debridement surgery and delayed wound closure or coverage...
March 15, 2024: Journal of Bone and Joint Surgery. American Volume
https://read.qxmd.com/read/38489085/streptococcus-taonis-sp-nov-a-novel-bacterial-species-isolated-from-a-blood-culture-of-a-patient
#9
JOURNAL ARTICLE
Chien-Yu Lee, Chin-Kan Chan, Momoko Chida, Mika Miyashita, Yun-Shien Lee, Hui-Chung Wu, Yu-Chung Chang, Wen-Ting Lin, Yi-Sheng Chen
One Gram stain-positive, catalase-negative, α-hemolytic, chain-forming or paired cocci, designated ST22-14T , was isolated from a blood culture of a child with suspected infection. The results of 16S rRNA gene sequences analyses showed that the most closely related species to strain ST22-14T were "Streptococcus vulneris" DM3B3T (99.2%), Streptococcus mitis NCTC 12261T (99.0%), "Streptococcus gwangjuense" ChDC B345T , (99.0%), Streptococcus oralis subsp. dentisani 7747T (99.0%), Streptococcus downii CECT 9732T (99...
March 15, 2024: Archives of Microbiology
https://read.qxmd.com/read/38487907/-intrauterin-infection-during-the-first-trimester-and-on-going-pregnancy
#10
Valérie Knapen, Éliane Saliba, Anne Jacmin
An intrauterine infection during the first trimester of pregnancy can rapidly lead to bacteremia, with severe consequences for the patient. While these infections are mainly found after a miscarriage or an abortion, the diagnosis is sometimes made while the pregnancy is still in progress. The clinical history and symptoms reported by the patient lead to the suspicion of such a complication. Treatment must be rapid and based on a broad-spectrum antibiotic regimen covering Gram-negative, Gram-positive, aerobic and anaerobic bacteria...
March 2024: Revue Médicale de Liège
https://read.qxmd.com/read/38487146/ventilator-associated-lower-respiratory-tract-infections-and-their-association-with-covid-19-a-retrospective-cohort-study-in-a-portuguese-intensive-treatment-unit
#11
JOURNAL ARTICLE
André Fernandes, Joao Nuno Patricio, Rita Jorge, Raquel Nazareth, Carlos S Pereira
Introduction Ventilator-associated pneumonia (VAP) is the most common infectious complication related to admission to an Intensive Treatment Unit (ITU). Ventilator-associated lower respiratory tract infection (VA-LRTI) is a broader diagnosis than VAP. By disregarding radiological criteria, it will include both VAP and ventilator-associated tracheobronchitis. This study, conducted in the setting of a Portuguese ITU, aims to study the incidence, microbiology and clinical outcome of VA-LRTI and its association with COVID-19...
February 2024: Curēus
https://read.qxmd.com/read/38487138/unveiling-gram-ghost-cells-a-crucial-aspect-of-gram-staining-in-the-covid-19-era
#12
Yoshiro Hadano
The term "Gram-ghost appearance" refers to mycobacteria's unique Gram staining characteristics. Recognizing Mycobacterium tuberculosis as a potential pathogen in respiratory infections, especially in the elderly during the COVID-19 pandemic, is critical. This case highlights the pivotal role of Gram staining in diagnosis, particularly when COVID-19 tests consistently show negative results. Recognition of Gram-ghost bacilli facilitated prompt tuberculosis diagnosis, emphasizing the enduring diagnostic value of Gram staining, especially in the COVID-19 era...
February 2024: Curēus
https://read.qxmd.com/read/38486799/light-sensitive-peg-hydrogel-with-antibacterial-performance-for-pacemaker-pocket-infection-prevention
#13
JOURNAL ARTICLE
Yurong Xiong, Qingyun Zhang, Juan Li, Nan Zhang, Xiaoshu Cheng, Quanbin Dong, Huihui Bao
Prevention of cardiovascular implantable electronic devices (CIED) infection is crucial for successful outcomes. In this study, we report an adhesive and antibacterial hydrogel coating for CIED infection treatment, by immobilizing polyethylene glycol (PEG) and 2'- O -hydroxypropyl trimethyl ammonium chloride chitosan (HAC) on Ti surface. Initial alkali and APTES treatment caused the formation of -NH2 to enhance the adhesion of the hydrogel coating to Ti implants, followed by immobilizing a photo-cross-linkable PEG/2'- O -HTACCS hydrogel on Ti/OH/NH2 surface...
April 2024: Materials today. Bio
https://read.qxmd.com/read/38486459/-in-silico-strategies-for-identifying-therapeutic-candidates-against-acinetobacter-baumannii-spotlight-on-the-udp-n-acetylmuramoyl-l-alanine-d-glutamate-meso-diaminopimelate-ligase-mure
#14
JOURNAL ARTICLE
Ankit Kumar, Pratyaksha Singh, Ekampreet Singh, Monika Jain, Jayaraman Muthukumaran, Amit Kumar Singh
The opportunistic bacterium Acinetobacter baumannii , which belongs to ESKAPE group of pathogenic bacteria, is leading cause of infections associated with gram-negative bacteria. Acinetobacter baumannii causes severe diseases, such as VAP (ventilator-associated pneumonia), meningitis, and UTI (urinary tract infections) among the nosocomial infections contracted in hospitals. The high infection rate and growing resistance to the vast array of antibiotics makes it paramount to look for new therapeutic strategies against this pathogen...
March 14, 2024: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/38486152/isolation-and-characterization-of-lytic-bacteriophages-from-various-sources-in-addis-ababa-against-antimicrobial-resistant-diarrheagenic-escherichia-coli-strains-and-evaluation-of-their-therapeutic-potential
#15
JOURNAL ARTICLE
Tamirat Salile Sada, Tesfaye Sisay Tessema
BACKGROUND: Escherichia coli is a common fecal coliform, facultative aerobic, gram-negative bacterium. Pathogenic strains of such microbes have evolved to cause diarrhea, urinary tract infections, and septicemias. The emergence of antibiotic resistance urged the identification of an alternative strategy. The use of lytic bacteriophages against the control of pathogenic E. coli in clinics and different environmental setups (waste and drink water management) has become an alternative therapy to antibiotic therapy...
March 14, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/38486043/enterobacter-asburiae-st229-an-emerging-carbapenemases-producer
#16
JOURNAL ARTICLE
Mattioni Marchetti Vittoria, Kuka Angela, Piazza Aurora, Gaiarsa Stefano, Merla Cristina, Sottasanti Mariangela, Cambieri Patrizia, Migliavacca Roberta, Baldanti Fausto
Enterobacter asburiae, member of the Enterobacter cloacae complex (ECC) group, shows an increasing clinical relevance being responsible for infections like pneumonia, urinary tract infections and septicemia. The aim of the present study was the investigation of the genomic features of two XDR E. asburiae ST229 clinical strains co-carrying blaNDM-1 and blaVIM-1 determinants, collected in October 2021 and in June 2022, respectively. Two E. asburiae strains were collected from rectal swabs of as many patients admitted to the cardiopulmonary intensive care unit of Fondazione I...
March 14, 2024: Scientific Reports
https://read.qxmd.com/read/38485529/catheter-associated-urinary-tract-infections-in-africa-systematic-review-and-meta-analysis
#17
REVIEW
Zelalem Asmare, Mulat Erkihun, Wagaw Abebe, Agenagnew Ashagre, Tadesse Misganaw, Sefineh Fenta Feleke
BACKGROUND: Catheter-associated urinary tract infections (CAUTIs) account for the majority of device-associated healthcare-acquired infections with significant morbidity and mortality worldwide. In developing countries with limited resources, the burden of CAUTI have substantial burden owing to the lack of well-organized infection prevention and control. Although there are studies in African countries, the magnitude of CAUTI is inconsistent. Therefore this systematic review and meta-analysis aimed to determine the pooled prevalence of CAUTI in Africa and identify the pathogens involved...
March 13, 2024: Infection, Disease & Health
https://read.qxmd.com/read/38484958/phenotypic-and-molecular-characterization-of-multi-drug-resistant-klebsiella-spp-isolates-recovered-from-clinical-settings
#18
JOURNAL ARTICLE
Hassan Diab, Kelven Rahy, Tamima Jisr, Mira El Chaar, Edmond Abboud, Sima Tokajian
Klebsiella pneumoniae is a Gram-negative bacterium that colonizes the gastrointestinal tract and nasopharynx with many being linked to nosocomial infections. Extended-spectrum β-lactamases (ESBL)-producing and carbapenem-resistant K. pneumoniae is recognized by the World Health Organization (WHO) as a critical public health concern. In this study, whole-genome sequencing (WGS) - based analysis was performed to understand the molecular epidemiology of multi-drug resistant Klebsiella spp. clinical isolates...
March 12, 2024: Infection, Genetics and Evolution
https://read.qxmd.com/read/38484602/effectiveness-of-vancomycin-powder-for-preventing-postoperative-spinal-infection
#19
JOURNAL ARTICLE
Sung-Woo Choi, Jin Yeong Hwang, Min Jung Baek, Jae Chul Lee, Hae-Dong Jang, Jae-Hyun Kim, Byung Joon Shin
OBJECTIVE: This study aimed to assess the effectiveness of Vancomycin Power (VP) and the occurrence of resistant organisms after four-year of routine VP use. METHODS: The study included 1063 patients who underwent posterior lumbar interbody fusion (PLIF) and transforaminal lumbar interbody fusion (TLIF) between January 2010 and February 2020. Intrawound VP was applied to all instrumented fusions starting in January 2016. The patients were divided into two groups: those who did not apply VP (non-VP) (n = 605) between 2010 and 2015, and those who did apply VP (VP) (n = 458) between 2016 and 2020...
March 2, 2024: Clinical Neurology and Neurosurgery
https://read.qxmd.com/read/38484349/molecular-analysis-of-multidrug-resistant-e-coli-in-pediatric-utis-findings-from-a-nigerian-hospital
#20
JOURNAL ARTICLE
Eunice Damilola Wilkie, Chidinma Vivian Ezeani, Deborah Oluwasola Olasehinde, Omolanke Temitope Oyedemi, Jude Oluwapelumi Alao, Anthonia Olufunke Oluduro, Oluwapelumi Breakthrough Oyetunde
INTRODUCTION: This study aimed to isolate and characterize antibiotic-resistant Escherichia coli from urine samples of children at the Mother and Child Hospital in Ondo State, Nigeria, assessing antibiogram profiling and resistance genes. METHODOLOGY: Three hundred urine samples (158 females, 142 males), aged 3-5 years, were collected, transported on ice, and analyzed bacteriologically. E. coli and Gram-negative bacteria were isolated using Eosin Methylene Blue agar and identified through colony morphology and biochemical tests...
February 29, 2024: Journal of Infection in Developing Countries
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