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https://www.readbyqxmd.com/read/28190657/cross-sectional-analysis-of-biobank-japan-clinical-data-a-large-cohort-of-200-000-patients-with-47-common-diseases
#1
Makoto Hirata, Yoichiro Kamatani, Akiko Nagai, Yutaka Kiyohara, Toshiharu Ninomiya, Akiko Tamakoshi, Zentaro Yamagata, Michiaki Kubo, Kaori Muto, Taisei Mushiroda, Yoshinori Murakami, Koichiro Yuji, Yoichi Furukawa, Hitoshi Zembutsu, Toshihiro Tanaka, Yozo Ohnishi, Yusuke Nakamura, Koichi Matsuda
BACKGROUND: To implement personalized medicine, we established a large-scale patient cohort, BioBank Japan, in 2003. BioBank Japan contains DNA, serum, and clinical information derived from approximately 200,000 patients with 47 diseases. Serum and clinical information were collected annually until 2012. METHODS: We analyzed clinical information of participants at enrollment, including age, sex, body mass index, hypertension, and smoking and drinking status, across 47 diseases, and compared the results with the Japanese database on Patient Survey and National Health and Nutrition Survey...
February 9, 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/28144052/evaluation-of-plasma-leptin-tumor-necrosis-factor-%C3%AE-and-prealbumin-as-prognostic-biomarkers-during-clinical-recovery-from-acute-exacerbations-of-chronic-obstructive-pulmonary-disease
#2
Anant Mohan, Sneh Arora, Arvind Uniyal, Rosemary Poulose, Kalpana Luthra, R M Pandey, Randeep Guleria
BACKGROUND: Inflammatory and nutritional biomarkers have an important bearing on outcomes of acute exacerbations of chronic obstructive pulmonary disease (AECOPD), but the temporal profile of these compounds during an acute episode is unclear. PATIENTS AND METHODS: Plasma leptin, prealbumin, and tumor necrosis factor-alpha (TNF-α) were estimated at baseline and before hospital discharge in patients with AECOPD. RESULTS: A total of 82 patients were evaluated (66 males; mean (standard deviation) age, 61...
January 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28143855/-nutraceuticals-in-relation-to-human-skeletal-muscle-and-exercise
#3
Colleen Siobhan Deane, Daniel J Wilkinson, Bethan E Phillips, Kenneth Smith, Timothy Etheridge, Philip J Atherton
Skeletal muscles have a fundamental role in locomotion and whole body metabolism, with muscle mass and quality being linked to improved health and even lifespan. Optimising nutrition in combination with exercise is considered an established, effective ergogenic practice for athletic performance. Importantly, exercise and nutritional approaches also remain arguably the most effective countermeasure for muscle dysfunction associated with ageing and numerous clinical conditions e.g. cancer cachexia, COPD and organ failure, via engendering favourable adaptations such as increased muscle mass and oxidative capacity...
January 31, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28100824/asthma-copd-overlap-syndrome-showed-more-exacerbations-however-lower-mortality-than-copd
#4
J-W Bai, B Mao, W-L Yang, S Liang, H-W Lu, J-F Xu
BACKGROUND: Asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) is a new determinate syndrome whose exact characteristics remain unclear. AIM: The objective of this study is to find more difference between ACOS and COPD. DESIGN: A retrospective study of ACOS and COPD in Chinese. METHODS: Data from 65 patients with ACOS and 65 patients with COPD were retrospectively collected and analyzed. The basis of this study was to compare the two groups while ruling out differences in age, sex and smoking history...
January 18, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28100361/-the-relationship-between-nutritional-status-and-oxidative-stress-markers-pulmonary-function-in-patients-with-stable-chronic-obstructive-pulmonary-disease
#5
X L Jiang, P Zhong, C L Huang, F He, X M Fan, X R Chen
Objective: To investigate the association between the nutritional status of patients with chronic obstructive pulmonary disease (COPD) and the levels of serum oxidative stress markers protein carbonyls (PC), malondialdehyde (MDA), 8-hydroxy-2'-deoxyguanosine (8-OHdG), total antioxidant capacity (TAC) and pulmonary function. Methods: 200 patients with stable COPD (the COPD group) and 100 healthy individuals (the control group) who visited during June 2014 and August 2014 were enrolled in our study. The levels of PC, MDA, 8-OHdG and TAC in serum were detected...
January 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28066619/clinical-management-of-chronic-obstructive-pulmonary-disease-patients-with-muscle-dysfunction
#6
REVIEW
Joaquim Gea, Carme Casadevall, Sergi Pascual, Mauricio Orozco-Levi, Esther Barreiro
Muscle dysfunction is frequently observed in chronic obstructive pulmonary disease (COPD) patients, contributing to their exercise limitation and a worsening prognosis. The main factor leading to limb muscle dysfunction is deconditioning, whereas respiratory muscle dysfunction is mostly the result of pulmonary hyperinflation. However, both limb and respiratory muscles are also influenced by other negative factors, including smoking, systemic inflammation, nutritional abnormalities, exacerbations and some drugs...
November 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28065635/meals-enhancing-nutrition-after-discharge-findings-from-a-pilot-randomized-controlled%C3%A2-trial
#7
David R Buys, Anthony D Campbell, Alice Godfryd, Kellie Flood, Elizabeth Kitchin, Meredith L Kilgore, Sally Allocca, Julie L Locher
BACKGROUND: After older adults experience episodes of poor health or are hospitalized, they may not return to premorbid or prehospitalization eating behaviors. Furthermore, poor nutrition increases hospital readmission risk, but evidence-based interventions addressing these risks are limited. OBJECTIVE: This pilot study's objective was to evaluate the feasibility of conducting a randomized controlled trial assessing a post-discharge home-delivered meal program's impact on older adults' nutritional intake and hospital readmissions and to assess patient acceptability and satisfaction with the program...
January 5, 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28054402/demographic-health-behavioral-and-self-management-abilities-associated-with-disease-severity-among-patients-with-chronic-obstructive-pulmonary-disease-an-exploratory-study
#8
Lan Wang, Yan-Xia Tao, Xiao-Yan Dong, Qing Zhang, Hong Zheng, Ya-Shu Zheng, Xing-Yue Tang, Jing-Rui Xu, Yue Zhao
This study aimed to identify the association between demographic characteristics, health behaviors, self-management abilities, and disease severity among patients with chronic obstructive pulmonary disease (COPD). The study was conducted from January to December 2015 in 4 hospitals in China. The DOSE index was assessed by grade of dyspnea (D), airflow obstruction (O), current smoking status (S), and frequency of exacerbation in the last year (E). Self-management abilities were assessed by the COPD self-management scale...
January 4, 2017: International Journal of Nursing Practice
https://www.readbyqxmd.com/read/28053845/prevalence-and-risk-factors-of-chronic-obstructive-pulmonary-disease-among-nonsmokers-fifth-korea-national-health-and-nutrition-examination-survey-2010-2012
#9
Heeyoung Oh, Ye-Eun Lee
OBJECTIVES: The purpose of this study was to determine the prevalence of COPD among non-smoking adults, and to investigate the risk factors that affect disease occurrence. METHODS: The data from the 5th Korea national health and nutrition examination survey (KNHNES) has been used, and 5,489 non-smoking adults aged between 40 to 79 years with diagnosable FEV1/FVC were selected therefrom as the subjects of this study. RESULTS: The prevalence of COPD in non-smokers was observed to be 6...
December 2016: Osong Public Health and Research Perspectives
https://www.readbyqxmd.com/read/28012805/clinical-implications-of-sarcopenia-on-decreased-bone-density-in-men-with-chronic-obstructive-pulmonary-disease
#10
Ji An Hwang, Young Sam Kim, Ah Young Leem, Moo Suk Park, Se Kyu Kim, Joon Chang, Ji Ye Jung
BACKGROUND: Sarcopenia and osteoporosis are systemic features of chronic obstructive pulmonary disease (COPD). The present study investigated the association between sarcopenia and osteopenia/osteoporosis, and the factors associated with low bone mineral density (BMD) in men with COPD. METHODS: Data of 777 men with COPD who underwent both pulmonary function test and dual energy X-ray absorptiometry were extracted from the Korean National Health and Nutritional Examination Survey database between 2008 and 2011...
December 21, 2016: Chest
https://www.readbyqxmd.com/read/27965941/health-related-quality-of-life-in-accordance-with-fracture-history-and-comorbidities-in-korean-patients-with-osteoporosis
#11
Hye-Young Kwon, Yong-Chan Ha, Jun-Il Yoo
BACKGROUND: The purpose of this study was to explore health-related quality of life (HRQOL) among Korean patients with osteoporosis and to measure the impact of fractures and comorbidity on their quality of life (QOL) using the Korean National Health and Nutrition Examination Survey (KNHANES) data with a nationwide representativeness. METHODS: This study was based on 4-year-data obtained from the KNHANES 2008 to 2011. Osteoporosis was diagnosed in 2,078 survey participants according to their bone mineral density measurements using dual energy X-ray absorptiometry...
November 2016: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/27942209/association-of-serum-ferritin-levels-with-smoking-and-lung-function-in-the-korean-adult-population-analysis-of-the-fourth-and-fifth-korean-national-health-and-nutrition-examination-survey
#12
Chan Ho Lee, Eun Kyung Goag, Su Hwan Lee, Kyung Soo Chung, Ji Ye Jung, Moo Suk Park, Young Sam Kim, Se Kyu Kim, Joon Chang, Joo Han Song
BACKGROUND: Iron-catalyzed oxidative stress contributes to lung injury after exposure to various toxins, including cigarette smoke. An oxidant/antioxidant imbalance is considered to play a critical role in the pathogenesis of COPD. Ferritin is a key protein in iron homeostasis, and its capacity to oxidize and sequester the metal preventing iron prooxidant activity implicates its possible role in the alteration of antioxidant imbalance. We investigated the relationship among cigarette smoking, lung function, and serum ferritin concentration in a large cohort representative of the Korean adult population...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27923983/sex-differences-in-function-and-structure-of-the-quadriceps-muscle-in-chronic-obstructive-pulmonary-disease-patients
#13
Pilar Ausín, Juana Martínez-Llorens, Marina Sabaté-Bresco, Carme Casadevall, Esther Barreiro, Joaquim Gea
Chronic obstructive pulmonary disease (COPD) is a complex disorder with extrapulmonary manifestations. Even though there is some knowledge regarding sex differences in the lung disease, little is known about extrapulmonary manifestations. Our aim was to analyze the specific profile of muscle dysfunction, structure, and biology in COPD women. Twenty-one women and 19 men with stable COPD as well as 15 controls were included. Nutritional status, physical activity, lung and muscle function, exercise capacity, and quality of life were assessed...
December 6, 2016: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/27900930/availability-of-pulmonary-rehabilitation-in-primary-care-for-patients-with-copd-a-cross-sectional-study-in-sweden
#14
Mats Arne, Margareta Emtner, Karin Lisspers, Karin Wadell, Björn Ställberg
BACKGROUND: Pulmonary rehabilitation (PR) is an important, evidence-based component for the management of individuals with chronic obstructive pulmonary disease (COPD). In daily practice, the majority of COPD patients are treated in primary care. However, information about the availability of PR in primary care in Sweden is lacking. The aim was to investigate the availability of rehabilitation resources in primary care settings for patients with COPD in Sweden. METHODS: A cross-sectional descriptive design was applied, using web-based questionnaires sent to all primary care centres in four regions, comprising more than half of the 9...
2016: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/27898452/chronic-obstructive-pulmonary-disease-and-malnutrition-in-developing-countries
#15
Inderpaul S Sehgal, Sahajal Dhooria, Ritesh Agarwal
PURPOSE OF REVIEW: Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disorder characterized by progressive, poorly reversible airflow limitation. In addition to its pulmonary manifestations, COPD is also associated with several systemic expressions including anemia, osteoporosis, coronary artery disease, and malnutrition. In COPD, malnutrition is a consequence of reduced nutritional intake and muscle loss, further compounded by systemic inflammation. In the developing world, malnutrition is a significant problem by itself, even without any systemic illness...
March 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/27890988/variability-in-proteinase-antiproteinase-balance-nutritional-status-and-quality-of-life-in-stable-chronic-obstructive-pulmonary-disease-due-to-tobacco-and-nontobacco-etiology
#16
Anant Mohan, Mini Sharma, Arvind Uniyal, Rajlaxmi Borah, Kalpana Luthra, R M Pandey, Karan Madan, Vijay Hadda, Randeep Guleria
CONTEXT: Although the role of proteinase/antiproteinase imbalance in chronic obstructive pulmonary disease (COPD) due to tobacco is well established, information in COPD due to nontobacco etiology is sparse. AIMS: To assess the variability in metalloproteinase activity in COPD related to tobacco and nontobacco causes. SETTINGS AND DESIGN: This is a hospital-based, prospective, observational study. SUBJECTS AND METHODS: Serum matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinases-1 (TIMP-1) were estimated in 200 subjects divided equally into four groups, i...
November 2016: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/27866758/the-influence-of-deprivation-on-malnutrition-risk-in-outpatients-with-chronic-obstructive-pulmonary-disease-copd
#17
P F Collins, M Elia, R J Kurukulaaratchy, R J Stratton
BACKGROUND & AIMS: The social gradient in chronic obstructive pulmonary disease (COPD) is considerable, but the influence of deprivation on common clinical risk factors such as malnutrition is unclear. This study aimed to explore the relationship between COPD disease-severity, deprivation and malnutrition. METHODS: 424 outpatients with a confirmed diagnosis of COPD were routinely screened for malnutrition risk using the 'Malnutrition Universal Screening Tool' ('MUST') while attending respiratory clinics across two hospitals; a large city hospital (site A) and a smaller community hospital (site B)...
November 11, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27843308/dietary-vitamin-c-intake-protects-against-copd-the-korea-national-health-and-nutrition-examination-survey-in-2012
#18
Hye Jung Park, Min Kwang Byun, Hyung Jung Kim, Jae Yeol Kim, Yu-Il Kim, Kwang-Ha Yoo, Eun Mi Chun, Ji Ye Jung, Sang Haak Lee, Chul Min Ahn
BACKGROUND: Vitamin C, as an antioxidant, has recently been suggested to provide protection against COPD; however, only few national cohort studies have investigated these effects. We aimed to confirm the protective effects of vitamin C against COPD in Korean patients. PATIENTS AND METHODS: We analyzed the data of 3,283 adults aged ≥40 years (representing 23,541,704 subjects) who underwent pulmonary function tests and responded to questionnaires on smoking history and vitamin C intake, with stratification variables and sampling weight designated by the Korea 2012 National Health and Nutrition Examination Survey...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27843307/the-effect-of-conjugated-linoleic-acid-supplementation-on-the-nutritional-status-of-copd-patients
#19
Hassan Ghobadi, Somaieh Matin, Ali Nemati, Abbas Naghizadeh-Baghi
BACKGROUND: COPD patients are susceptible to anorexia, reduction of caloric intake, weight loss, and malnutrition. One of the possible mechanisms is the increase of inflammatory markers such as interleukin 1β (IL1β), is highly correlated with anorexia. Considering the anti-inflammatory role of conjugated linoleic acid (CLA), this study aimed to investigate the effect of CLA supplementation on the nutritional status of COPD patients. PATIENTS AND METHODS: In a double-blind clinical trial, 93 COPD patients who volunteered to participate in the study and who filled out a written consent form, were randomly assigned to control or supplementation groups...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27837039/low-risk-for-local-and-systemic-complications-after-primary-repair-of-1626-achilles-tendon-ruptures
#20
Nicholas Rensing, Brian R Waterman, Rachel M Frank, Kenneth A Heida, Justin D Orr
INTRODUCTION: Historically, Achilles tendon repairs and other surgeries about the hindfoot have demonstrated a significantly higher rate of wound healing complications and surgical site morbidity. The purpose of this study was to evaluate the comprehensive complication profile and risk factors for adverse short-term, clinical outcomes after primary repair of Achilles tendon ruptures. METHODS: Between the years 2005 and 2014, all cases of primary Achilles tendon repair (Current Procedural Terminology code 27650) entered into the National Surgical Quality Improvement Project (NSQIP) database were extracted for analysis...
November 10, 2016: Foot & Ankle Specialist
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