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https://www.readbyqxmd.com/read/29349620/fatal-talaromyces-marneffei-infection-in-a-patient-with-autoimmune-hepatitis
#1
Sally C Y Wong, Siddharth Sridhar, Antonio H Y Ngan, Jonathan H K Chen, Rosana W S Poon, Susanna K P Lau, Patrick C Y Woo
Talaromyces marneffei, previously known as Penicillium marneffei, is the most important pathogenic thermally dimorphic fungus causing systemic mycosis in Southeast Asia. Traditionally, T. marneffei infection in human was mainly associated with acquired immunodeficiency syndrome caused by HIV infection. In recent years, there has been an increasing number of T. marneffei infections reported in non-HIV-infected patients with other immunocompromised conditions, including autoantibodies against interferon-gamma, systemic lupus erythematosis, solid organ transplantation, Job's syndrome, hematological malignancies, and use of novel targeted therapies...
January 18, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29348388/disseminated-histoplasmosis-in-an-indonesian-hiv-positive-patient-a-case-diagnosed-by-fine-needle-aspiration-cytology
#2
Nungki Anggorowati, Rita C Sulistyaningsih, Ahmad Ghozali, Yanri W Subronto
A 30-year-old Javanese-Indonesian man was admitted with complaints of 3 months persistent fever, weight loss, and fatigue. He had never known his past history of unprotected HIV until the admission. His only risk factor is unsafe sex. The patient seemed well nourished. Physical examination revealed blood pressure 100/60 mmHg, pulse 100 beats per minute, respiratory rate 20 times per minute, and temperature 38.8°C. Multiple cervical and inguinal lymphadenopathies were also found. Electrocardiogram showed anterolateral ischemic finding, whereas chest X-ray were normal...
October 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/29347903/child-caregiver-and-health-care-provider-perspectives-and-experiences-regarding-disclosure-of-hiv-status-to-perinatally-infected-children-in-lima-peru
#3
Amira Noori Baker, Angela Marie Bayer, Lenka Kolevic, Lizzete Najarro, Rolando Mario Viani, Jaime Gerardo Deville
BACKGROUND: Despite recommendations for disclosure of HIV status to children living with HIV (CLHIV), fewer than half of CLHIV at the Instituto Nacional de Salud del Niño (INSN) in Lima, Peru, have had disclosure. How and when the disclosure process for CLHIV should take place in Peru has not been studied. METHODS: We conducted a qualitative study at INSN to explore perceptions and experiences of 6 health care providers (HCPs), 14 disclosed and nondisclosed CLHIV (8-17 years), and their 14 caregivers regarding knowledge of illness, disclosure of HIV status, and appropriate disclosure approaches...
January 2018: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/29346632/diagnostic-and-prognostic-value-of-jc-virus-dna-in-plasma-in-progressive-multifocal-leukoencephalopathy
#4
Francesca Ferretti, Arabella Bestetti, Constantin T Yiannoutsos, Beverly S Musick, Simonetta Gerevini, Laura Passeri, Simona Bossolasco, Antonio Boschini, Diego Franciotta, Adriano Lazzarin, Paola Cinque
Background: Progressive multifocal leukoencephalopathy (PML) is a severe demyelinating disease caused by the polyomavirus JC (JCV) affecting subjects with impaired immune system. While JCV-DNA detection in cerebrospinal fluid (CSF) is diagnostic of PML, the clinical significance of plasma JCV-DNA is still uncertain. Methods: We retrospectively analyzed plasma samples drawn from patients with PML close to disease onset, and controls without PML. In PML patients, we compared plasma JCV DNA detection and levels to: JCV DNA in the other biological samples, clinical and laboratory parameters and patients' survival...
January 15, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29346384/histoplasmosis-in-africa-an-emerging-or-a-neglected-disease
#5
REVIEW
Rita O Oladele, Olusola O Ayanlowo, Malcolm D Richardson, David W Denning
Histoplasmosis in Africa has markedly increased since the advent of the HIV/AIDS epidemic but is under-recognised. Pulmonary histoplasmosis may be misdiagnosed as tuberculosis (TB). In the last six decades (1952-2017), 470 cases of histoplasmosis have been reported. HIV-infected patients accounted for 38% (178) of the cases. West Africa had the highest number of recorded cases with 179; the majority (162 cases) were caused by Histoplasma capsulatum var. dubuosii (Hcd). From the Southern African region, 150 cases have been reported, and the majority (119) were caused by H...
January 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29346184/synergistic-impact-of-training-followed-by-on-site-support-on-hiv-clinical-practice-a-mixed-design-study-in-uganda-with-pre-post-and-cluster-randomized-trial-components
#6
Sarah Burnett, Norbert Mubiru, Peace Imani, Martin K Mbonye, Leigh Fisher, Robert Colebunders, Yukari C Manabe, Marcia R Weaver
BACKGROUND: Task-shifting can expand antiretroviral therapy access, but little is known about effective approaches to improve clinical practice among mid-level practitioners' (MLP) such as clinical officers, nurses, and midwives. The Integrated Infectious Diseases Capacity-Building Evaluation compared training alone to training combined with on-site support (OSS). METHODS: Two MLP each from 36 health facilities attended the five-week Integrated Management of Infectious Disease training...
January 16, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29344502/orbital-epstein-barr-virus-positive-polymorphic-b-cell-lymphoproliferative-disorder-in-an-apparently-immunocompetent-woman
#7
Michael D Abendroth, Michael G Bayerl, Michael J Wilkinson, David F Claxton, Charles S Specht
We report a rare case of Epstein-Barr virus (EBV)-positive polymorphic B-cell lymphoproliferative disorder (LPD) involving the lacrimal gland of a 28-year-old, apparently immunocompetent woman. She presented with a chief complaint of orbital swelling and tenderness and was found to have a lesion involving the right lacrimal gland and distal superior and lateral rectus muscles. Histology of the lesion revealed histiocytes with pleomorphic nuclei, reactive lymphocytes, and scattered cells that resembled the Reed-Sternberg (R-S) cells of classical Hodgkin lymphoma...
December 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29343948/types-and-delivery-of-emotional-support-to-promote-linkage-and-engagement-in-hiv-care
#8
Christa L Cook, Shantrel Canidate, Nicole Ennis, Robert L Cook
Purpose: Despite recommendations for early entry into human immunodeficiency virus (HIV) care, many people diagnosed with HIV delay seeking care. Multiple types of social support (ie, cognitive, emotional, and tangible) are often needed for someone to transition into HIV care, but a lack of emotional support at diagnosis may be the reason why some people fail to stay engaged in care. Thus, the purpose of this study was to identify how people living with HIV conceptualized emotional support needs and delivery at diagnosis...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29343423/request-for-hiv-serology-in-primary-care-a-survey-of-medical-and-nursing-professionals
#9
Myrian Pichiule-Castañeda, M Felicitas Domínguez-Berjón, María D Esteban-Vasallo, Carmen García-Riolobos, M Carmen Álvarez-Castillo, Jenaro Astray-Mochales
INTRODUCTION: In the Community of Madrid there is 42.7% late HIV diagnosis. Primary care is the gateway to the health system and the frequency of serological tests requested by these professionals is unknown. The objectives were to establish the frequency of requests for HIV serology by medical and nursing primary care professionals in the Community of Madrid and the factors associated with these requests. METHOD: An 'on-line' survey was conducted, asking professionals who participated in the evaluation study of strategies to promote early diagnosis of HIV in primary care in the Community of Madrid (ESTVIH) about the number of HIV-serology tests requested in the last 12 months...
January 15, 2018: Enfermería Clínica
https://www.readbyqxmd.com/read/29342259/false-starts-in-test-and-start-a-qualitative-study-of-reasons-for-delayed-antiretroviral-therapy-in-swaziland
#10
Christopher Pell, Eva Vernooij, Nelisiwe Masilela, Njabulo Simelane, Fortunate Shabalala, Ria Reis
Background: Test and start, antiretroviral therapy (ART) for all HIV-positive individuals, is a WHO-recommended treatment guideline. In Swaziland, test and start has been evaluated through the MaxART implementation study. This article examines why, in MaxART, some newly diagnosed HIV-positive clients delayed initiating ART. Methods: Thirteen HIV-positive clients who delayed ART for ≥90 d after testing were identified from the MaxART study database and interviewed...
January 12, 2018: International Health
https://www.readbyqxmd.com/read/29342172/driving-factors-of-retention-in-care-among-hiv-positive-msm-and-transwomen-in-indonesia-a-cross-sectional-study
#11
Adi Nugroho, Vicki Erasmus, Robert W S Coulter, Sushil Koirala, Oranuch Nampaisan, Wirastra Pamungkas, Jan Hendrik Richardus
Little is known about the prevalence of and factors that influence retention in HIV-related care among Indonesian men who have sex with men (MSM) and transgender women (transwomen, or waria in Indonesian term). Therefore, we explored the driving factors of retention in care among HIV-positive MSM and waria in Indonesia. This cross-sectional study involved 298 self-reported HIV-positive MSM (n = 165) and waria (n = 133). Participants were recruited using targeted sampling and interviewed using a structured questionnaire...
2018: PloS One
https://www.readbyqxmd.com/read/29342162/comparison-of-diagnostic-methods-to-detect-histoplasma-capsulatum-in-serum-and-blood-samples-from-aids-patients
#12
Katia Cristina Dantas, Roseli Santos de Freitas, Marcos Vinicius da Silva, Paulo Ricardo Criado, Olinda do Carmo Luiz, Adriana Pardini Vicentini
BACKGROUND: Although early and rapid detection of histoplasmosis is essential to prevent morbidity and mortality, few diagnostic tools are available in resource-limited areas, especially where it is endemic and HIV/AIDS is also epidemic. Thus, we compared conventional and molecular methods to detect Histoplasma capsulatum in sera and blood from HIV/AIDS patients. METHODOLOGY: We collected a total of 40 samples from control volunteers and patients suspected of histoplasmosis, some of whom were also infected with other pathogens...
2018: PloS One
https://www.readbyqxmd.com/read/29341953/lethality-among-patients-with-hiv-aids-monitored-in-the-clinic-of-infectious-diseases-in-st-george-university-hospital-plovdiv-2010-2014
#13
Mariyana V Stoycheva, Nikolay T Vatev, Vania B Georgieva, Antonina P Dineva, Maria V Atanasova, Tatiana A Popova
BACKGROUND: The introduction of complex antiretroviral therapy has resulted in signifi cant decrease in the mortality rate of HIV positive patients, but it still remains unacceptably high, especially in some groups of patients. AIM: To investigate the death rate in patients with HIV/AIDS, lethality and mortality in co-infection, and the most common causes and predictors of fatal outcome, focused on early diagnosis and appropriate therapy. MATERIALS AND METHODS: The study included 53 deceased patients with HIV/AIDS, monitored at the Clinic of Infectious Diseases in St George University Hospital, Plovdiv between 01...
December 20, 2017: Folia Medica
https://www.readbyqxmd.com/read/29340329/a-salivary-urea-nitrogen-dipstick-to-detect%C3%A2-obstetric-related-acute-kidney-disease-in-malawi
#14
Rhys D R Evans, William Cooke, Ulla Hemmila, Viviane Calice-Silva, Jochen Raimann, Alison Craik, Chimwemwe Mandula, Priscilla Mvula, Ausbert Msusa, Gavin Dreyer, Nathan W Levin, Roberto Pecoits-Filho
Introduction: Obstetric-related acute kidney injury (AKI) is associated with adverse outcomes for mother and fetus, particularly in low-income countries. However, laboratory-independent tools to facilitate diagnosis are lacking. We assessed the diagnostic performance of a salivary urea nitrogen (SUN) dipstick to detect obstetric-related acute kidney disease in Malawi. Methods: Women at high risk for AKI admitted to an obstetric unit in Blantyre, Malawi, were recruited between 21 September and 11 December 2015...
January 2018: KI Reports
https://www.readbyqxmd.com/read/29338717/risk-factors-for-acute-respiratory-infections-in%C3%A2-children-under-five-years-attending-the-bamenda-regional-hospital-in-cameroon
#15
Alexis A Tazinya, Gregory E Halle-Ekane, Lawrence T Mbuagbaw, Martin Abanda, Julius Atashili, Marie Therese Obama
BACKGROUND: Acute respiratory infections (ARI) are a leading cause of morbidity and mortality in under-five children worldwide. About 6.6 million children less than 5 years of age die every year in the world; 95% of them in low-income countries and one third of the total deaths is due to ARI. This study aimed at determining the proportion of acute respiratory infections and the associated risk factors in children under 5 years visiting the Bamenda Regional Hospital in Cameroon. METHODS: A cross-sectional analytic study involving 512 children under 5 years was carried out from December 2014 to February 2015...
January 16, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29338331/the-impact-of-hiv-diagnosis-on-length-of-hospital-stay-in-new%C3%A2-york-city-ny-usa
#16
Tawandra L Rowell-Cunsolo, Jianfang Liu, Yanhan Shen, Amber Britton, Elaine Larson
While hospitalizations among people living with human immunodeficiency virus (PLWH) have been elevated in the past compared to their uninfected counterparts, the introduction of antiretroviral therapy (ART) has resulted in great strides in controlling symptomatic infection. However, research largely overlooks important differences among HIV-infected individuals, primarily PLWH who are symptomatic versus those who are asymptomatic. We conducted a retrospective study assessing the length of hospital stay among 717,237 admissions from three hospitals in the New York City area...
January 17, 2018: AIDS Care
https://www.readbyqxmd.com/read/29336695/-ghosts-from-the-past-the-re-emergence-of-internalised-religious-stigma-following-diagnosis-of-hiv-among-northern-irish-gay-men
#17
Keith Kerrigan, Gill Green
This paper explores how previous exposure to religious homo-negativity features in the sense making process following HIV diagnosis in a homogenous sample of six gay men living in Northern Ireland. Interpretive Phenomenological Analysis was used to identify two key overarching themes: 'Negotiating authenticity in unsafe space' which relates to the experience of negotiating same sex attraction within religious environments and 'Re-emergence of religious shame in diagnosis' which relates to the way in which the men made sense of diagnosis from the position of having been exposed to religious homo-negativity earlier in their lives...
January 16, 2018: Journal of Homosexuality
https://www.readbyqxmd.com/read/29336508/national-audit-of-perinatal-hiv-infections-in-the-uk-2006-2013-what-lessons-can-be-learnt
#18
H Peters, C Thorne, P A Tookey, L Byrne
OBJECTIVES: The aim of the study was to investigate circumstances surrounding perinatal transmissions of HIV (PHIVs) in the UK. METHODS: The National Study of HIV in Pregnancy and Childhood conducts comprehensive surveillance of all pregnancies in women diagnosed with HIV infection and their infants in the UK; reports of all HIV-diagnosed children are also sought, regardless of country of birth. Children with PHIV born in 2006-2013 and reported by 2014 were included in an audit, with additional data collection via telephone interviews with clinicians involved in each case...
January 16, 2018: HIV Medicine
https://www.readbyqxmd.com/read/29336111/beyond-mere-pill-taking-sms-reminders-for-hiv-treatment-adherence-delivered-to-mobile-phones-of-clients-in-a-community-support-network-in-australia
#19
Limin Mao, Andrew Buchanan, Horas Tze Hoo Wong, Asha Persson
SMS reminders sent to personal mobiles are increasingly used by clinical services to promote patient engagement, including adherence to antiretroviral treatment (ART) for HIV. From August to September 2015, a 6-week, randomised SMS reminder for ART adherence intervention was implemented among 98 HIV-positive clients of Australian's largest HIV charitable organisation located in Sydney. This was followed by a mixed-method evaluation, comprising a self-completed online survey and a one-to-one interview. Of the 62 survey participants, all being men, the majority were gay (85...
January 15, 2018: Health & Social Care in the Community
https://www.readbyqxmd.com/read/29335843/study-on-the-clinical-features-and-prognosis-of-penicilliosis-marneffei-without-human-immunodeficiency-virus-infection
#20
Ying-Ge Wang, Jin-Mei Cheng, Hai-Bo Ding, Xi Lin, Guo-Hao Chen, Mei Zhou, Sheng-Nan Ye
OBJECTIVE: To improve the diagnosis and treatment of Penicilliosis marneffei without human immunodeficiency virus infection. METHODS: Analyze and review the clinical features, diagnosis and treatment of six cases of P. marneffei without human immunodeficiency virus infection at The First Affiliated Hospital of Fujian Medical University. RESULTS: Two cases were diagnosed in the ENT Department, three cases in the respiratory department and one case in the dermatological department...
January 15, 2018: Mycopathologia
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