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https://www.readbyqxmd.com/read/29147593/rapidly-progressive-disseminated-sporotrichosis-as-the-first-presentation-of-hiv-infection-in-a-patient-with-a-very-low-cd4-cell-count
#1
Isis Cristine Morávia Ribeiro de Oliveira-Esteves, Guilherme Almeida Rosa da Silva, Walter de Araujo Eyer-Silva, Rodrigo Panno Basílio-de-Oliveira, Luciana Ferreira de Araujo, Carlos José Martins, Rogério Neves-Motta, Marcelo Costa Velho Mendes de Azevedo, Dario José Hart Pontes Signorini, Jorge Francisco da Cunha Pinto, Lívia Machado Moura, Rafael Jacyntho Laterça, Diogo Raphael Garcia de Oliveira Pereira, Isabela Vieira do Lago, Fernando Raphael de Almeida Ferry
Sporotrichosis is a human and animal disease caused by species of the Sporothrix schenckii complex. It is classically acquired through traumatic inoculation of fungal elements. Most frequently, sporotrichosis presents as a fixed cutaneous or as a lymphocutaneous form. A much smaller number of cases occur as cutaneous disseminated and disseminated forms. These cases require immediate diagnosis and management to reduce morbidity and mortality. We present the case of a 34-year-old male patient in whom the first presentation of HIV infection was a rapidly progressive sporotrichosis with multiple cutaneous lesions, a high fungal burden in tissues, and pulmonary involvement...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/29146286/-genital-herpes-and-pregnancy-epidemiology-clinical-manifestations-prevention-and-screening-guidelines-for-clinical-practice-from-the-french-college-of-gynecologists-and-obstetrician-cngof
#2
O Picone
OBJECTIVES: To analyze the consequences of genital herpes infections in pregnant women. METHODS: The PubMed database and the recommendations from the French and foreign obstetrical societies or colleges have been consulted. RESULTS: The symptomatology of herpes genital rash is often atypical (NP2) and not different during pregnancy (Professional consensus). It is most often due to HSV2 (NP2). Seventy percent of pregnant patients have a history of infection with Herpes simplex virus, without reference to genital or labial localization, and this is in most cases type 1 (NP2)...
November 13, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29143681/economic-evaluation-of-hcv-testing-approaches-in-low-and-middle-income-countries
#3
REVIEW
Jake R Morgan, Maria Servidone, Philippa Easterbrook, Benjamin P Linas
BACKGROUND: Hepatitis C virus (HCV) infection represents a major public health burden with diverse epidemics worldwide, but at present, only a minority of infected persons have been tested and are aware of their diagnosis. The advent of highly effective direct acting antiviral (DAA) therapy, which is becoming available at increasingly lower costs in low and middle income countries (LMICs), represents a major opportunity to expand access to testing and treatment. However, there is uncertainty as to the optimal testing approaches and who to prioritize for testing...
November 1, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29143620/optimising-diagnosis-of-viraemic-hepatitis-c-infection-the-development-of-a-target-product-profile
#4
Elena Ivanova Reipold, Philippa Easterbrook, Alessandra Trianni, Nivedha Panneer, Douglas Krakower, Stefano Ongarello, Teri Roberts, Veronica Miller, Claudia Denkinger
BACKGROUND: The current low access to virological testing to confirm chronic viraemic HCV infection in low- and middle-income countries (LMIC) is limiting the rollout of hepatitis C (HCV) care. Existing tests are complex, costly and require sophisticated laboratory infrastructure. Diagnostic manufacturers need guidance on the optimal characteristics a virological test needs to have to ensure the greatest impact on HCV diagnosis and treatment in LMIC. Our objective was to develop a target product profile (TPP) for diagnosis of HCV viraemia using a global stakeholder consensus-based approach...
November 1, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29143619/diagnostic-accuracy-of-tests-to-detect-hepatitis-b-surface-antigen-a-systematic-review-of-the-literature-and-meta-analysis
#5
Ali Amini, Olivia Varsaneux, Helen Kelly, Weiming Tang, Wen Chen, Debrah I Boeras, Jane Falconer, Joseph D Tucker, Roger Chou, Azumi Ishizaki, Philippa Easterbrook, Rosanna W Peeling
BACKGROUND: Chronic Hepatitis B Virus (HBV) infection is characterised by the persistence of hepatitis B surface antigen (HBsAg). Expanding HBV diagnosis and treatment programmes into low resource settings will require high quality but inexpensive rapid diagnostic tests (RDTs) in addition to laboratory-based enzyme immunoassays (EIAs) to detect HBsAg. The purpose of this review is to assess the clinical accuracy of available diagnostic tests to detect HBsAg to inform recommendations on testing strategies in 2017 WHO hepatitis testing guidelines...
November 1, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29143609/survey-of-programmatic-experiences-and-challenges-in-delivery-of-hepatitis-b-and-c-testing-in-low-and-middle-income-countries
#6
Azumi Ishizaki, Julie Bouscaillou, Niklas Luhmann, Stephanie Liu, Raissa Chua, Nick Walsh, Sarah Hess, Elena Ivanova, Teri Roberts, Philippa Easterbrook
BACKGROUND: There have been few reports on programmatic experience of viral hepatitis testing and treatment in resource-limited settings. To inform the development of the 2017 World Health Organization (WHO) viral hepatitis testing guidance and in particular the feasibility of proposed recommendations, we undertook a survey across a range of organisations engaged with hepatitis testing in low- and middle-income countries (LMICs). Our objective was to describe current hepatitis B and C testing practices across a range of settings in different countries, as well as key barriers or challenges encountered and proposed solutions to promote testing scale-up...
November 1, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29143162/anti-retroviral-status-and-hiv-transmission-risk-behaviors-are-associated-with-age-time-since-diagnosis-and-psychosocial-factors-among-women-living-with-hiv-aids-enrolling-in-the-willow-intervention-at-community-based-organizations
#7
Weston O Williams, Tanesha Griffin, Gary Uhl
Safe sexual behaviors and anti-retroviral use help prevent HIV transmission. In this cross-sectional study, we assessed correlates of anti-retroviral (ART) status and transmission risk (a constructed variable) among a convenience sample of n = 1041 HIV-positive women (pre-intervention) enrolled in an evidence-based intervention at four CBOs. Multinomial logistic regression models were used. Younger women and those diagnosed with HIV in the last 5 years more often reported that they had not been prescribed ART...
November 15, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29141790/cerebral-toxoplasmosis-in-an-ms-patient-receiving-fingolimod
#8
Alejandro Enriquez-Marulanda, Jaime Valderrama-Chaparro, Laura Parrado, Juan Diego Vélez, Ana Maria Granados, Jorge Luis Orozco, Jairo Quiñones
Multiple Sclerosis (MS) is an autoimmune disease in which lymphocytes target putative myelin antigens in the CNS, causing inflammation and neurodegeneration. Fingolimod (FTY720) is an immunosuppressive drug used as a second line therapy for relapsing forms of MS due to its safety profile and good response to treatment. Despite its safety, there are still concerns about the possibility of Fingolimod being linked to the development of opportunistic infections like disseminated varicella zoster infections and herpes simplex encephalitis...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29141709/rapid-diagnostic-testing-of-hospitalized-malawian-children-reveals-opportunities-for-improved-hiv-diagnosis-and-treatment
#9
Theresa F Madaline, Sarah E Hochman, Karl B Seydel, Alice Liomba, Alex Saidi, Grace Matebule, Wenzhu B Mowrey, Bernadette O'Hare, Danny A Milner, Kami Kim
Recent World Health Organization (WHO) guidelines recommend antiretroviral therapy (ART) for all HIV-infected people; previously CD4+ T lymphocyte quantification (CD4 count) or clinical staging determined eligibility for children ≥ 5 years old in low- and middle-income countries. We examined positive predictive value (PPV) of a rapid diagnostic test (RDT) algorithm and ART eligibility for hospitalized children with newly diagnosed HIV infection. We enrolled 363 hospitalized Malawian children age 2 months to 16 years with two serial positive HIV RDT from 2013 to 2015...
October 16, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29141339/-survival-time-of-hiv-aids-cases-and-related-factors-in-beijing-1995-2015
#10
Y Li, J Wang, S F He, J Chen, H Y Lu
Objective: To analyze the survival time of HIV/AIDS cases and related factors in Beijing from 1995 to 2015. Methods: A retrospective cohort study was conducted to analyze the data of 12 874 HIV/AIDS cases. The data were collected from Chinese HIV/AIDS Comprehensive Information Management System. Life table method was applied to calculate the survival proportion, and Cox proportion hazard regression model were used to identify the factors related with survival time. Results: Among 12 874 HIV/AIDS cases, 303 (2...
November 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29140946/comparison-of-the-quantiferon-tb-gold-in-tube-assay-with-tuberculin-skin-test-for-the-diagnosis-of-latent-tuberculosis-infection-among-hiv-infected-and-uninfected-children
#11
Walter Dehority, Rolando M Viani, Maria Rosario G Araneta, Graciano Lopez, Stephen A Spector
BACKGROUND: Diagnosis of latent tuberculosis infection (LTBI) is facilitated by tuberculin skin testing (TST) or interferon-gamma release assays such as the QuantiFERON TB Gold In-Tube (QTF-GIT) assays. Limited data exist on the utility of interferon-gamma release assays in HIV-infected children, which may be falsely negative due to immunosuppression. METHODS: A cross-sectional study comparing TST to QTF-GIT for the diagnosis of suspected LTBI was performed in children in Tijuana, Mexico, and in San Diego, California...
December 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29140432/long-term-immune-response-to-yellow-fever-vaccination-in-hiv-infected-individuals-depends-on-hiv-rna-suppression-status-implications-for-vaccination-schedule
#12
Olivia Veit, Cristina Domingo, Matthias Niedrig, Cornelia Staehelin, Beat Sonderegger, Héquet Delphine, Marcel Stoeckle, Alexandra Calmy, Veronique Schiffer, Enos Bernasconi, Domenica Flury, Christoph Hatz, Marcel Zwahlen, Hansjakob Furrer
Background: In HIV-infected individuals the immune response over time to yellow fever vaccination (YFV) and the necessity for booster vaccination are not well understood. Methods: We studied 247 participants of the Swiss HIV Cohort Study (SHCS) with a first YFV after HIV diagnosis and determined their immune responses at one, five, and ten years postvaccination (p.v.) by yellow fever plaque reduction neutralisation titres (PRNT) in stored blood samples. A PRNT of 1:≥10 was regarded as reactive and protective...
November 11, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29136117/cost-effectiveness-of-community-based-hiv-self-testing-in-blantyre-malawi
#13
Hendramoorthy Maheswaran, Aileen Clarke, Peter MacPherson, Felistas Kumwenda, David G Lalloo, Elizabeth L Corbett, Stavros Petrou
Background: HIV self-testing (HIVST) is effective, with scale-up underway in sub-Saharan Africa. We assessed cost-effectiveness of adding HIVST to existing facility-based HIV testing and counselling (HTC) services. Both 2010 (initiate at CD4<350 cells/μl) and 2015 (initiate all) WHO guidelines for antiretroviral treatment (ART) were considered. Methods: A microsimulation model was developed that evaluated cost-effectiveness, from both health provider and societal perspectives, of an HIVST service implemented in a cluster-randomised trial (CRT) (ISRCTN02004005) in Malawi...
November 9, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29136011/ten-year-experience-with-antiretroviral-treatment-in-cambodia-trends-in-patient-characteristics-and-treatment-outcomes
#14
Phirum Lay, Sokkab An, Sunpiseth Soeung, Pich Sovannary Srey, Sopheak Thai, Lutgarde Lynen, Johan van Griensven
BACKGROUND: Although HIV disease stage at ART initiation critically determines ART outcomes, few reports have longitudinally monitored this within Asia. Using prospectively collected data from a large ART program at Sihanouk Hospital Center of Hope in Cambodia, we report on the change in patient characteristics and outcomes over a ten-year period. METHODS: We conducted a retrospective analysis including all adults (≥ 18 years old) starting ART from March 2003-March 2013 in a non-governmental hospital in Phnom Penh, Cambodia...
2017: PloS One
https://www.readbyqxmd.com/read/29136001/a-combination-intervention-strategy-to-improve-linkage-to-and-retention-in-hiv-care-following-diagnosis-in-mozambique-a-cluster-randomized-study
#15
Batya Elul, Matthew R Lamb, Maria Lahuerta, Fatima Abacassamo, Laurence Ahoua, Stephanie A Kujawski, Maria Tomo, Ilesh Jani
BACKGROUND: Concerning gaps in the HIV care continuum compromise individual and population health. We evaluated a combination intervention strategy (CIS) targeting prevalent barriers to timely linkage and sustained retention in HIV care in Mozambique. METHODS AND FINDINGS: In this cluster-randomized trial, 10 primary health facilities in the city of Maputo and Inhambane Province were randomly assigned to provide the CIS or the standard of care (SOC). The CIS included point-of-care CD4 testing at the time of diagnosis, accelerated ART initiation, and short message service (SMS) health messages and appointment reminders...
November 2017: PLoS Medicine
https://www.readbyqxmd.com/read/29135773/tree-based-claims-algorithm-for-measuring-pretreatment-quality-of-care-in-medicare-disabled-hepatitis-c-patients
#16
Viktor V Chirikov, Fadia T Shaya, Ebere Onukwugha, C Daniel Mullins, Susan dosReis, Charles D Howell
BACKGROUND: To help broaden the use of machine-learning approaches in health services research, we provide an easy-to-follow framework on the implementation of random forests and apply it to identify quality of care (QC) patterns correlated with treatment receipt among Medicare disabled patients with hepatitis C virus (HCV). METHODS: Using Medicare claims 2006-2009, we identified 1936 patients with 6 months continuous enrollment before HCV diagnosis. We ran a random forest on 14 pretreatment QC indicators, extracted the forest's representative tree, and aggregated its terminal nodes into 4 QC groups predictive of treatment...
December 2017: Medical Care
https://www.readbyqxmd.com/read/29135652/are-hiv-seroconversions-among-young-men-who-have-sex-with-men-associated-with-social-network-proximity-to-recently-or-long-term-hiv-infected-individuals
#17
Ethan Morgan, Britt Skaathun, Rebeccah Duvoisin, Stuart Michaels, John A Schneider
Debate remains as to the relative HIV transmission contributions from individuals who are recently HIV infected and individuals who have long-term infections. In this study, we examine the relationship between new HIV seroconversions occurring among young Black men who have sex with men (YBMSM) and network proximity to recently or long-term HIV infected individuals. A cohort of YBMSM (N = 618) was generated through respondent driven sampling across three waves. A recent HIV infection was defined as either: 1) a confirmed seroconversion ≤9 months prior to interview date or 2) a laboratory confirmed acute infection; long-term HIV infected individuals were defined as a diagnosis date ≥9 months prior to interview date...
November 8, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29135582/hiv-is-associated-with-airway-obstruction-a-matched-controlled-study
#18
Alain Makinson, Maurice Hayot, Sabrina Eymard-Duvernay, Céline Ribet, François Raffi, Gilles Pialoux, David Zucman, Isabelle Poizot-Martin, Fabrice Bonnet, Sophie Abgrall, Pierre Tattevin, Antoine Cheret, Tristan Ferry, Jean-Marc Mauboussin, Lucie Marchand, Claire Rouzaud, Jacques Reynes, Marie Zins, Vincent Le Moing
OBJECTIVE: to explore whether airway obstruction (AO) is associated with HIV in a cohort of HIV-infected and uninfected smokers. METHODS: People living with HIV (PLWHIV) participated in the ANRS EP48 HIV CHEST study, an early lung cancer diagnosis study with low dose Chest Tomography. HIV-uninfected subjects were from the CONSTANCES cohort. Inclusion criteria were an age > 40 years, a smoking history ≥20 pack-years, and for PLWHIV, a CD4 T-lymphocyte nadir < 350/μl and last CD4 cell count > 100 cells/μl...
November 10, 2017: AIDS
https://www.readbyqxmd.com/read/29135578/when-prevention-of-mother-to-child-hiv-transmission-fails-preventing-pretreatment-drug-resistance-in-african-children
#19
Seth C Inzaule, Raph L Hamers, Job Calis, Ragna Boerma, Kim Sigaloff, Clement Zeh, Peter Mugyenyi, Sulaimon Akanmu, Tobias F Rinke de Wit
: The scale-up of antiretroviral prophylaxis to prevent mother-to-child transmission of HIV has significantly reduced new pediatric infections in sub-Saharan Africa. However, among infants who become HIV-infected despite prevent mother-to-child transmission, more than 50% have drug-resistant HIV. Given high levels of resistance, WHO recommends the use of protease inhibitors as part of first-line pediatric antiretroviral therapy (ART) to optimize treatment response, but costs and logistic challenges restrict access...
November 10, 2017: AIDS
https://www.readbyqxmd.com/read/29135386/timing-of-diagnosis-understanding-resilience-narratives-of-hiv-positive-older-adults-diagnosed-pre-and-post-haart
#20
Lesley M Harris, Charles A Emlet, Christina Pierpaoli Parker, Charles Furlotte
BACKGROUND: Despite the growing population of older adults living with HIV/AIDS, few studies have examined this population in terms of timing of HIV diagnosis. This study explores resilience and protective factors among HIV-positive older adults, 17 of whom were diagnosed prior to the development of highly active antiretroviral therapy (HAART), and 13 of whom were diagnosed after the development HAART. METHODS: We explored the concepts of resilience and protective factors in 30 older adults living with HIV in Ontario, Canada...
November 14, 2017: Journal of Gerontological Social Work
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