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https://www.readbyqxmd.com/read/28809988/methods-for-imputing-missing-efficacy-data-in-clinical-trials-of-biologic-psoriasis-therapies-implications-for-interpretations-of-trial-results
#1
Richard G B Langley, Kristian Reich, Charis Papavassilis, Todd Fox, Yankun Gong, Achim Gu Ttner
<p>BACKGROUND: An issue in long-term clinical trials of biologics in psoriasis is how to handle missing efficacy data. This methodological challenge may not be understood by clinicians, yet can have a significant effect on the interpretation of clinical trials.</p> <p>OBJECTIVE Evaluate the effects of different data imputation methods on apparent secukinumab response rates.</p> <p>METHODS: Post hoc analyses were conducted on efficacy data from 2 phase III, multicenter, randomized, double-blind trials (FIXTURE and ERASURE) of secukinumab in moderate to severe plaque psoriasis...
August 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28795586/fixture-congestion-modulates-post-match-recovery-kinetics-in-professional-soccer-players
#2
Tommy R Lundberg, Kristoffer Weckström
This study examined the influence of fixture congestion on physical performance and biochemical variables in professional male footballers. After 3 competitive matches within a week (3M cycle), 16 players underwent blood sampling and field testing 72 h after the last match. The same tests were performed after a regular 1 match-week cycle (1M cycle). The 1M vs. 3M change scores were compared between Congested (high match exposure) and non-selected Control players. The change score in muscle soreness was greater (effect size 1...
August 10, 2017: Research in Sports Medicine
https://www.readbyqxmd.com/read/28791307/atlantoaxial-misalignment-causes-high-blood-pressure-in-rats-a-novel-hypertension-model
#3
Zong-Bao He, You-Kui Lv, Hui Li, Qiong Yao, Ke-Ming Wang, Xiao-Ge Song, Zi-Jian Wu, Ximing Qin
Atlantoaxial disorders are often correlated with hypertension in practice. In order to study the relationship between atlantoaxial disorder and hypertension, we attempted to construct an animal model. In this work, we presented an animal model where their atlantoaxial joints were misaligned. We investigated the changes of blood pressure before and after treatments of the modeled rats. We had the following results. (1) SBP and DBP of each surgery group were significantly higher than those of control and sham groups...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28758035/selectable-implant-removal-methods-due-to-mechanical-and-biological-failures
#4
Jong-Bin Lee
Dental implant has been restoring the function and esthetics lost from missing tooth. However, biomechanical implant complications are the major cause of failing implants. Therefore, implant removal is one of the indispensable dental treatments. The 70-year-old male and 66-year-old female who had discomfort on posterior implants region came to Department of Periodontology. Conventional method using trephine bur and the new, nontraumatic method using a fixture removal kit were used for implant removal, respectively...
2017: Case Reports in Dentistry
https://www.readbyqxmd.com/read/28757930/efficacy-of-a-new-coating-of-implant-abutment-connections-in-reducing-bacterial-loading-an-in-vitro-study
#5
D Lauritano, C A Bignozzi, D Pazzi, F Cura, F Carinci
BACKGROUND: Titanium is the gold standard for dental implants, since it has demonstrated excellent biocompatibility and osseointegration properties. The rate of osseointegration is however affected by the surface morphology and peri-implant infections may affect fixture and the long-term osseointegration outcome. Thus chemical composition of a coating at the implant-abutment junction (IAJ) surface is expected to play a key role in preventing bacterial infection. PURPOSE: In the present study a new antimicrobial polysiloxane coating functionalized with chlorexidine digluconate (PXT) has been tested in an in vitro model...
January 2017: Oral & Implantology
https://www.readbyqxmd.com/read/28721107/bite-force-and-dental-implant-treatment-a-short-review
#6
REVIEW
Dennis Flanagan
Dental implants are placed endosseously, and the bone is the ultimate bearer of the occlusal load. Patients are not uniform in the maximum bite force they can generate. The occlusal biting load in the posterior jaw is usually about three times of that found in the anterior. It is possible for supporting implants to be overloaded by the patients' biting force, resulting in bone loss and failure of the fixture. Bite force measurement may be an important parameter when planning dental implant treatment. Some patients can generate extreme biting loads that may cause a luxation of the fixture and subsequent loss of osseointegration...
2017: Medical Devices: Evidence and Research
https://www.readbyqxmd.com/read/28718315/ulnar-styloid-base-fractures-cause-distal-radioulnar-joint-instability-in-a-cadaveric-model
#7
Tyler S Pidgeon, Joseph J Crisco, Gregory R Waryasz, Douglas C Moore, Manuel F DaSilva
BACKGROUND: The deep portion of the distal radioulnar ligaments (DRUL) inserts on the ulnar fovea and is the most important stabilizer of the distal radioulnar joint (DRUJ). Ulnar styloid base fractures that include the ulnar fovea may cause DRUJ instability. METHODS: DRUJ stability in pronosupination was evaluated in 12 fresh-frozen upper extremities (4 female) aged 52 to 68 years (mean: 58.8 years) using a custom fixture, which allowed free rotation of the radius around the fixed ulna...
January 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28696831/preliminary-testing-by-adults-of-a-haptics-assisted-robot-platform-designed-for-children-with-physical-impairments-to-access-play
#8
Isao Sakamaki, Kim Adams, Maria Fernanda Gomez Medina, Javier Leonardo Castellanos Cruz, Nooshin Jafari, Mahdi Tavakoli, Heidi Janz
Development of children's cognitive and perceptual skills depends heavily on object exploration and experience in their physical world. For children who have severe physical impairments, one of the biggest concerns is the loss of opportunities for meaningful play with objects, including physical contact and manipulation. Assistive robots can enable children to perform object manipulation through the control of simple interfaces. Touch sensations conveyed through haptic interfaces in the form of force reflection or force assistance can help a child to sense the environment and to control a robot...
July 11, 2017: Assistive Technology: the Official Journal of RESNA
https://www.readbyqxmd.com/read/28695184/the-stability-of-dual-taper-modular-hip-implants-a-biomechanical-analysis-examining-the-effect-of-impact-location-on-component-stability
#9
Nicholas B Frisch, Jonathan R Lynch, Richard F Banglmaier, Craig D Silverton
BACKGROUND: The purpose of this study was to investigate the stability of dual-taper modular implants following impaction forces delivered at varying locations as measured by the distraction forces required to disassemble the components. METHODS: Distraction of the head-neck and neck-stem (NS) tapers of dual-taper modular implants with 0°, 8°, and 15° neck angles were measured utilizing a custom-made distraction fixture attached to a servohydraulic materials test machine...
June 2017: Arthroplasty Today
https://www.readbyqxmd.com/read/28692851/a-simple-device-to-convert-a-small-animal-pet-scanner-into-a-multi-sample-tissue-and-injection-syringe-counter
#10
Michael V Green, Jurgen Seidel, Peter L Choyke, Elaine M Jagoda
INTRODUCTION: We describe a simple fixture that can be added to the imaging bed of a small-animal PET scanner that allows for automated counting of multiple organ or tissue samples from mouse-sized animals and counting of injection syringes prior to administration of the radiotracer. The combination of imaging and counting capabilities in the same machine offers advantages in certain experimental settings. METHODS: A polyethylene block of plastic, sculpted to mate with the animal imaging bed of a small-animal PET scanner, is machined to receive twelve 5-ml containers, each capable of holding an entire organ from a mouse-sized animal...
June 3, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28691586/low-cost-volumetric-ultrasound-by-augmentation-of-2d-systems-design-and-prototype
#11
Carl D Herickhoff, Matthew R Morgan, Joshua S Broder, Jeremy J Dahl
Conventional two-dimensional (2D) ultrasound imaging is a powerful diagnostic tool in the hands of an experienced user, yet 2D ultrasound remains clinically underutilized and inherently incomplete, with output being very operator dependent. Volumetric ultrasound systems can more fully capture a three-dimensional (3D) region of interest, but current 3D systems require specialized transducers, are prohibitively expensive for many clinical departments, and do not register image orientation with respect to the patient; these systems are designed to provide improved workflow rather than operator independence...
July 1, 2017: Ultrasonic Imaging
https://www.readbyqxmd.com/read/28684153/application-of-computer-assisted-three-dimensional-simulation-operation-and-biomechanics-analysis-in-the-treatment-of-sagittal-craniosynostosis
#12
Xiang Li, Wanchun Zhu, Jintao He, Fei Di, Lei Wang, Xin Li, Wei Liu, Chunde Li, Jian Gong
As a surgical method to treat children with sagittal craniosynostosis, calvarial vault reconstruction is subjected to some limitations. In traditional surgical method to treat children with sagittal craniosynostosis, surgical resection and fixation are performed all by the experience of surgical doctor, which is likely to cause individual differences, insecure fixation, configurational asymmetry, and waste of unnecessary fixtures materials. This study aims to provide surgical doctor with objective indicators via 3D simulation combined with biomechanical calculation, so as to improve the surgical efficiency...
July 3, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28668619/internal-training-load-and-its-longitudinal-relationship-with-seasonal-player-wellness-in-elite-professional-soccer
#13
Filipe Manuel Clemente, Bruno Mendes, Pantelis Theodoros Nikolaidis, Francisco Calvete, Sandro Carriço, Adam Lee Owen
Monitoring internal training load has been extensively used and described within team sport environments, however when compared to internal physiological measures such as heart rate (HR) and rating of perceived exertion (RPE), the literature is sparse. The primary aim of this investigation study was to assess differences of playing position on ITL, session-RPE and wellness across two different training microcycles (1 vs. 2 competitive games), in addition with examining the relationship between ITL and Hooper's Index across an entire season...
June 28, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28655434/immediate-full-arch-rehabilitation-of-the-severely-atrophic-maxilla-supported-by-zygomatic-implants-a-prospective-clinical-study-with-minimum-follow-up-of-6-years
#14
E L Agliardi, D Romeo, S Panigatti, M de Araújo Nobre, P Maló
The aim of this study was to evaluate the outcomes of immediate full-arch prostheses supported by zygomatic implants alone or in combination with standard fixtures after a minimum of 6 years of loading. From October 2008 to April 2010, 15 patients with severely atrophic maxillae were treated using four zygomatic implants or two zygomatic implants in conjunction with two conventional fixtures. All subjects received a fixed screw-retained prosthesis within 3hours of surgery, while the final restoration was delivered after 6 months...
June 24, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28651855/assessment-of-pose-repeatability-and-specimen-repositioning-of-a-robotic-joint-testing-platform
#15
H El Daou, B Lord, A Amis, F Rodriguez Y Baena
This paper describes the quantitative assessment of a robotic testing platform, consisting of an industrial robot and a universal force-moment sensor, via the design of fixtures used to hold the tibia and femur of cadaveric knees. This platform was used to study the contributions of different soft tissues and the ability of implants and reconstruction surgeries to restore normal joint functions, in previously published literature. To compare different conditions of human joints, it is essential to reposition specimens with high precision after they have been removed for a surgical procedure...
June 23, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28639032/case-study-microbial-ecology-and-forensics-of-chinese-drywall-elemental-sulfur-disproportionation-as-primary-generator-of-hydrogen-sulfide
#16
Francisco A Tomei Torres
Drywall manufactured in China released foul odors attributed to volatile sulfur compounds. These included hydrogen sulfide, methyl mercaptan, and sulfur dioxide. Given that calcium sulfate is the main component of drywall, one would suspect bacterial reduction of sulfate to sulfide as the primary culprit. However, when the forensics, i.e., the microbial and chemical signatures left in the drywall, are studied, the evidence suggests that, rather than dissimilatory sulfate reduction, disproportionation of elemental sulfur to hydrogen sulfide and sulfate was actually the primary cause of the malodors...
June 21, 2017: Microbial Ecology
https://www.readbyqxmd.com/read/28634495/choking-hazards-are-current-product-testing-methods-for-small-parts-adequate
#17
Athena Neofotistos, Nancy Cowles, Ragini Sharma
Choking on small parts remains one of the leading causes of death and injury in infants and toddlers. The current method of testing for small parts, created by the Consumer Product Safety Commission (CPSC), has become outdated and has yet to be changed despite the many deaths and injuries of children. The method uses a device called the small parts test fixture (SPTF) that is supposed to mimic the size of a fully expanded throat of a toddler. If a product does not fit inside the cavity of the SPTF, then it is deemed safe to play with because it "will not fit" in the esophagus of a child...
2017: International Journal of Pediatrics
https://www.readbyqxmd.com/read/28626763/implant-stability-in-the-posterior-maxilla-a-controlled-clinical-trial
#18
Raquel Zita Gomes, Mario Ramalho de Vasconcelos, Isabel Maria Lopes Guerra, Rute Alexandra Borges de Almeida, Antonio Cabral de Campos Felino
AIM: To evaluate the primary and secondary stability of implants in the posterior maxilla. METHODS: Patients were allocated into three groups: (A) native bone, (B) partially regenerated bone, and (C) nearly totally regenerated bone. Insertion torque (IT) and implant stability quotient (ISQ) were measured at placement, to evaluate whether satisfactory high primary stability (IT ≥ 45 N/cm; ISQ ≥ 60) was achieved; ISQ was measured 15, 30, 45, and 60 days after placement, to investigate the evolution to secondary stability...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28623680/what-are-the-incidence-and-factors-associated-with-implant-fracture
#19
Reza Tabrizi, Hossein Behnia, Shahram Taherian, Nima Hesami
PURPOSE: Implant fracture is a serious complication, which leads to treatment failure. The purpose of this study is to estimate the incidence of implant fractures and identify factors associated with them. MATERIALS AND METHODS: In this retrospective cohort study, the sample was derived from 2 implant centers. The predictors were grouped into the following categories: demographic, location of implant, physical characteristic of implant, implant-abutment connection, type of prosthesis, type of retention, and outcome variable (time to implant fracture)...
May 24, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28600383/validation-of-static-and-dynamic-radiostereometric-analysis-of-the-knee-joint-using-bone-models-from-ct-data
#20
K Stentz-Olesen, E T Nielsen, S De Raedt, P B Jørgensen, O G Sørensen, B L Kaptein, M S Andersen, M Stilling
OBJECTIVES: Static radiostereometric analysis (RSA) using implanted markers is considered the most accurate system for the evaluation of prosthesis migration. By using CT bone models instead of markers, combined with a dynamic RSA system, a non-invasive measurement of joint movement is enabled. This method is more accurate than current 3D skin marker-based tracking systems. The purpose of this study was to evaluate the accuracy of the CT model method for measuring knee joint kinematics in static and dynamic RSA using the marker method as the benchmark...
June 2017: Bone & Joint Research
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