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https://www.readbyqxmd.com/read/27856432/efficacy-and-safety-of-sarilumab-monotherapy-versus-adalimumab-monotherapy-for-the-treatment-of-patients-with-active-rheumatoid-arthritis-monarch-a-randomised-double-blind-parallel-group-phase-iii-trial
#1
Gerd R Burmester, Yong Lin, Rahul Patel, Janet van Adelsberg, Erin K Mangan, Neil M H Graham, Hubert van Hoogstraten, Deborah Bauer, Juan Ignacio Vargas, Eun Bong Lee
OBJECTIVES: To compare efficacy and safety of sarilumab monotherapy with adalimumab monotherapy in patients with active rheumatoid arthritis (RA) who should not continue treatment with methotrexate (MTX) due to intolerance or inadequate response. METHODS: MONARCH was a randomised, active-controlled, double-blind, double-dummy, phase III superiority trial. Patients received sarilumab (200 mg every 2 weeks (q2w)) or adalimumab (40 mg q2w) monotherapy for 24 weeks...
November 17, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27855478/interventions-for-treating-burning-mouth-syndrome
#2
REVIEW
Roddy McMillan, Heli Forssell, John Ag Buchanan, Anne-Marie Glenny, Jo C Weldon, Joanna M Zakrzewska
BACKGROUND: Burning mouth syndrome (BMS) is a term used for oral mucosal pain (burning pain or discomfort in the tongue, lips or entire oral cavity) without identifiable cause. General population prevalence varies from 0.1% to 3.9%. Many BMS patients indicate anxiety, depression, personality disorders and impaired quality of life (QoL). This review updates the previous versions published in 2000 and 2005. OBJECTIVES: To determine the effectiveness and safety of any intervention versus placebo for symptom relief and changes in QoL, taste, and feeling of dryness in people with BMS...
November 18, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27819409/interventions-for-chronic-kidney-disease-associated-restless-legs-syndrome
#3
REVIEW
Seerapani Gopaluni, Mohamed Sherif, Naim A Ahmadouk
BACKGROUND: Restless legs syndrome (RLS) is defined as the spontaneous movement of the limbs (mainly legs) associated with unpleasant, sometimes painful sensation which is relieved by moving the affected limb. Prevalence of RLS among people on dialysis has been estimated between 6.6% and 80%. RLS symptoms contribute to impaired quality of life and people with RLS are shown to have increased cardiovascular morbidity and mortality.Various pharmacological and non-pharmacological interventions have been used to treat primary RLS...
November 7, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27813685/physical-activity-and-intermittent-postconcussion-symptoms-after-a-period-of-symptom-limited-physical-and-cognitive-rest
#4
Quinton Sawyer, Brian Vesci, Tamara C Valovich McLeod
: Reference: Schneider KJ, Iverson GL, Emery CA, McCrory P, Herring SA, Meeuwisse WH. The effects of rest and treatment following sport-related concussion: a systematic review of the literature. Br J Sports Med. 2013;47(5):304-307. Clinical Question After concussion and a period of symptom-limited physical and cognitive rest, do athletes who experience intermittent symptoms return to asymptomatic condition more quickly with physical activity than with prolonged physical rest? DATA SOURCES: One investigator performed an individual search for each research question using the following databases: CINAHL, Cochrane Controlled Trials Registers, EMBASE, HealthSTAR, ProQuest, PsychInfo, PubMed, SPORTDiscus, and Web of Science...
November 4, 2016: Journal of Athletic Training
https://www.readbyqxmd.com/read/27807690/inpatient-treatment-effect-and-minnesota-multiphasic-personality-inventory-characteristics-of-motor-vehicle-collision-injuries-in-a-traditional-korean-medicine-hospital-retrospective-chart-review
#5
Min-Yeong Song, Hee-Guen Jo, Jae-Uk Sul, Seong-Tae Kim, Kil-Joon Bae, Tae-Gwang Kim, Jae-Hong Kim, Jin-Bong Choi
OBJECTIVES: To examine the changes in pain, disability, and quality of life in motor vehicle collision injury (MVCI) patients after treatment with traditional Korean medicine (TKM), and to investigate the psychological characteristics of these patients. METHODS: Forty-one patients with MVCI were treated with TKM including acupuncture, pharmacopuncture, moxibustion, cupping, herbal medication, chuna manual therapy, and physical therapy. Numeric Rating Scale (NRS), Medical Outcomes Study 36-Item Short Form Health Survey (SF-36), Neck Disability Index (NDI), Oswestry Disability Index (ODI), and Lysholm Knee Scoring Scale were assessed at admission and discharge...
November 3, 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27774361/application-of-the-harms-technique-to-treat-undiagnosed-intractable-c1-c2-unilateral-neck-pain-a-case-report
#6
Adnan Bashir Bhatti, Sunny Kim
A 79-year-old female presented with incapacitating chronic neck pain. The patient's pain which was greatest on the left side persisted for 18 months and was described as stabbing in nature (10/10 intensity). In addition to her neck pain, the patient described having frequent headaches. After six weeks of physical therapy and undergoing a rhizotomy procedure, she showed no prolonged improvement. An epidural steroid injection provided only temporary pain relief and was followed by a successful posterior fusion using the Harms technique with iliac crest autogenous bone grafting and placement of polyaxial screws in the C1 lateral masses and C2 pedicles...
September 21, 2016: Curēus
https://www.readbyqxmd.com/read/27760084/effect-of-gua-sha-therapy-on-perimenopausal-syndrome-a-randomized-controlled-trial
#7
Fang Meng, Pei-Bei Duan, Junya Zhu, Qing-Qing Lou, Zhao-Hui Fang, Hong-Li An, Lan-Ying Liu, Yue Hu, Qian Hu
OBJECTIVE: This study aims to evaluate the effectiveness and safety of Gua sha therapy on perimenopausal symptoms, quality of life, and serum female hormones in participants with perimenopausal syndrome. METHODS: A prospective, randomized, controlled clinical trial was conducted at the First Affiliated Hospital of Nanjing University of Chinese Medicine in China. Eighty women with perimenopausal syndrome were recruited and randomized into an intervention group or a control group...
October 10, 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27754180/ed-08-4-diagnosis-and-treatment-of-hypertensive-emergency-in-children
#8
Lin Shi
According to the seventh report of Joint National Committee (JNC 7), hypertensive emergency (HE), a kind of hypertensive crisis, is defined as a sudden and abrupt elevation in blood pressure so as to cause acute target organ dysfunctions, including central nervous system, cardiovascular system or kidneys. Patients with HE require immediate reduction in markedly elevated blood pressure. Currently, there are no international guidelines for children HE, so the JNC definition is commonly used. Hypertensive emergency in children is rare but a life-threatening emergency...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27747518/secukinumab-a-new-treatment-option-for-psoriatic-arthritis
#9
Philip Mease, Iain B McInnes
INTRODUCTION: Psoriatic arthritis (PsA) is an immune-mediated chronic inflammatory arthropathy associated with impaired physical function and reduced quality of life. Biologic therapies that target tumor necrosis factor (anti-TNF) have significantly improved clinical outcomes. Partial, non- and transient responses remain common comprising significant unmet clinical need. New therapies with novel modes of action are urgently required. OBJECTIVES: The interleukin (IL)-17 pathway has recently been attributed a critical role in the pathogenesis of spondyloarthritides...
June 2016: Rheumatology and Therapy
https://www.readbyqxmd.com/read/27741995/diagnosis-and-treatment-of-central-nervous-system-infections-in-the-emergency-department
#10
Maia Dorsett, Stephen Y Liang
Central nervous system (CNS) infections, including meningitis, encephalitis, and brain abscess, are rare but time-sensitive emergency department (ED) diagnoses. Patients with CNS infection can present to the ED with nonspecific signs and symptoms, including headache, fever, altered mental status, and behavioral changes. Neuroimaging and CSF fluid analysis can appear benign early in the course of disease. Delaying therapy negatively impacts outcomes, particularly with bacterial meningitis and herpes simplex virus encephalitis...
November 2016: Emergency Medicine Clinics of North America
https://www.readbyqxmd.com/read/27730651/management-of-mal-de-debarquement-syndrome-as-vestibular-migraines
#11
Yaser Ghavami, Yarah M Haidar, Kasra N Ziai, Omid Moshtaghi, Jay Bhatt, Harrison W Lin, Hamid R Djalilian
OBJECTIVE: Mal de debarquement syndrome (MdDS) is a balance disorder that typically starts after an extended exposure to passive motion, such as a boat or plane ride. Management is typically supportive (e.g. physical therapy), and symptoms that persist beyond 6 months have been described as unlikely to remit. This study was conducted to evaluate the response of patients with MdDS to management with migraine prophylaxis, including lifestyle changes and medical therapy. STUDY DESIGN: Prospective review...
October 12, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27695246/meningitis-with-polymerase-chain-reaction-for-varicella-zoster-positivity-in-cerebrospinal-flid-of-a-young-immunocompetent-adult
#12
Pooja Gupta, Rajeev Ranjan, C S Agrawal, K Muralikrishnan, Nikhil Dave, Davinder Singh Rana
Meningitis caused by varicella zoster virus (VZV) is quite rare among young immunocompetent adults though immunocompromised patients are often seen to be affected by reactivation of VZV presenting with primary clinical features of dermatomal rashes and neurological sequelae. Here, we report the clinical scenario of a young, healthy male who had presented with fever, headache, and onset of dermatomal rashes later than the fever and was eventually diagnosed to be a case of VZV meningitis. We would like to highlight the fact that even young immunocompetent patients though rarely, might contract VZV meningitis and clinicians should have a high index of suspicion and keen eyes to catch the more obvious features of VZV infection on complete physical examination and must not harbor any reservations in ordering polymerase chain reaction for VZV DNA or initiating aggressive antiviral therapy...
October 2016: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/27687372/transnasal-sphenopalatine-ganglion-block-for-the-treatment-of-postdural-puncture-headache-in-obstetric-patients
#13
Sheffield Kent, Gregory Mehaffey
STUDY OBJECTIVE: To demonstrate a possible alternative treatment for postdural puncture headache (PDPH). DESIGN: Postdural puncture headache is a common complication associated with neuraxial anesthesia and unintentional dural puncture. Epidural blood patch (EBP) is the standard therapy for PDPH but has risks including pain, dural puncture, and infection. Transnasal sphenopalatine ganglion block (SPGB) has been successfully used to treat migraine, cluster headache, and trigeminal neuralgia...
November 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27676320/headache-disorders-may-be-a-risk-factor-for-the-development-of-new-onset-hypothyroidism
#14
Andrew T Martin, Susan M Pinney, Changchun Xie, Robert L Herrick, Yun Bai, Jeanette Buckholz, Vincent T Martin
OBJECTIVE: To determine whether headache disorders are a risk factor for the development of new onset hypothyroidism. BACKGROUND: Past studies have reported associations between headache disorders and hypothyroidism, but the directionality of the association is unknown. METHODS: This was a longitudinal retrospective cohort study using data from the Fernald Medical Monitoring Program (FMMP). Residents received physical examinations and thyroid function testing every 3 years during the 20 year program...
September 27, 2016: Headache
https://www.readbyqxmd.com/read/27668944/factors-related-to-the-changes-in-quality-of-life-for-patients-with-depression-after-an-acute-course-of-electroconvulsive-therapy
#15
Chun-Jen Huang, Yu-Hui Huang, Ching-Hua Lin
OBJECTIVE: The aim of this study was to examine the effect of electroconvulsive therapy (ECT) on quality of life (QOL), depressive symptoms, and functioning for patients with depression, and to explore the variables related to QOL changes. METHODS: Ninety-five inpatients with depression receiving at least 6 ECT sessions and completed all measures were included. Quality of life, symptom severity, and functioning were assessed using Short Form 36 (SF-36), the 17-item Hamilton Rating Scale for Depression (HAMD-17), and the Modified Work and Social Adjustment Scale (MWSAS), before and after ECT...
September 23, 2016: Journal of ECT
https://www.readbyqxmd.com/read/27643137/ed-08-4-diagnosis-and-treatment-of-hypertensive-emergency-in-children
#16
Lin Shi
According to the seventh report of Joint National Committee (JNC 7), hypertensive emergency (HE), a kind of hypertensive crisis, is defined as a sudden and abrupt elevation in blood pressure so as to cause acute target organ dysfunctions, including central nervous system, cardiovascular system or kidneys. Patients with HE require immediate reduction in markedly elevated blood pressure. Currently, there are no international guidelines for children HE, so the JNC definition is commonly used. Hypertensive emergency in children is rare but a life-threatening emergency...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27638079/posttraumatic-dizziness-and-vertigo
#17
M Szczupak, M E Hoffer, S Murphy, C D Balaban
Traumatic brain injury is an increasingly common public health issue, with the mild variant most clinically relevant for this chapter. Common causes of mild traumatic brain injury (mTBI) include motor vehicle accidents, athletics, and military training/deployment. Despite a range of clinically available testing platforms, diagnosis of mTBI remains challenging. Symptoms are primarily neurosensory, and include dizziness, hearing problems, headaches, cognitive, and sleep disturbances. Dizziness is nearly universally present in all mTBI patients, and is the easiest symptom to objectify for diagnosis...
2016: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/27620871/graded-aerobic-treadmill-testing-in-pediatric-sports-related-concussion-safety-clinical-use-and-patient-outcomes
#18
Dean Cordingley, Richard Girardin, Karen Reimer, Lesley Ritchie, Jeff Leiter, Kelly Russell, Michael J Ellis
OBJECTIVE The objectives of this study were 2-fold: 1) to evaluate the safety, tolerability, and clinical use of graded aerobic treadmill testing in pediatric patients with sports-related concussion (SRC), and 2) to evaluate the clinical outcomes of treatment with a submaximal aerobic exercise program in patients with physiological post-concussion disorder (PCD). METHODS The authors conducted a retrospective chart review of pediatric patients (age < 20 years) with SRC who were referred to a multidisciplinary pediatric concussion program and underwent graded aerobic treadmill testing between October 9, 2014, and February 11, 2016...
December 2016: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/27605479/-a-case-of-spontaneous-cerebrospinal-fluid-leak-associated-with-cervical-spondylosis
#19
Atsushi Arai, Hirohito Miyamoto, Ryoji Shiomi, Shotaro Tatsumi, Eiji Kohmura
Spontaneous cerebrospinal fluid leak and intracranial hypotension associated with cervical spondylosis have rarely been observed, and only a few cases are reported. A 69-year-old woman, previously treated for rectal and thyroid cancer, complained of a non-postural persistent headache. The patient regularly practiced aerobic exercise, but a month earlier she had started experiencing headache and neck pain while exercising. Computed tomography(CT)showed bilateral chronic subdural hematomas, and magnetic resonance imaging(MRI)revealed diffuse dural enhancement and tonsillar herniation...
September 2016: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/27582619/cervico-cephalalgiaphobia-a-subtype-of-phobia-in-patients-with-cervicogenic-headache-and-neck-pain-a-pilot-study
#20
Rob A B Oostendorp, Hans Elvers, Emilia Mikolajewska, Nathalie Roussel, Emiel van Trijffel, Han Samwel, Jo Nijs, William Duquet
OBJECTIVES: The term 'cephalalgiaphobia' was introduced in the mid-1980s and defined as fear of migraine (attacks). We hypothesized that a specific subtype of cephalalgiaphobia affects patients with cervicogenic headache (CEH). This study aimed to: (1) define the term 'cervico-cephalalgiaphobia'; (2) develop a set of indicators for phobia relevant to patients with CEH; and (3) apply this set to a practice test in order to estimate the frequency of cervico-cephalalgiaphobia in the Dutch primary care practice of manual physical therapy...
September 2016: Journal of Manual & Manipulative Therapy
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