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https://www.readbyqxmd.com/read/28639011/guselkumab-for-the-treatment-of-psoriasis-a-review-of-phase-iii-trials
#1
REVIEW
Mio Nakamura, Katherine Lee, Caleb Jeon, Sahil Sekhon, Ladan Afifi, Di Yan, Kristina Lee, Tina Bhutani
INTRODUCTION: Interleukin (IL)-23 inhibitors are a new class of biologics currently undergoing clinical trials for the treatment of moderate-to-severe psoriasis. Phase III studies of guselkumab, an IL-23 receptor monoclonal antibody, are currently underway. METHODS: We summarize the available phase III results to date, establishing the efficacy and safety of guselkumab in patients with moderate-to-severe plaque psoriasis. RESULTS: Currently, there are available data of up to 48 weeks from two Phase III, multicenter, randomized, double-blind, placebo- and comparator-controlled clinical trials, VOYAGE 1 and VOYAGE 2...
June 21, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28636184/pharmacokinetics-pharmacodynamics-of-bococizumab-a-monoclonal-antibody-to-pcsk9-after-single-subcutaneous-injection-at-3-sites-nct-02043301
#2
Ellen Q Wang, Anna Plotka, Joanne Salageanu, Catherine Sattler, Carla Yunis
AIM: To characterize the single-dose pharmacokinetics (PK) and pharmacodynamics (PD) of bococizumab, a monoclonal antibody inhibiting proprotein convertase subtilisin/kexin type 9 (PCSK9), administered subcutaneously (s.c.) to the abdomen, thigh, or upper arm (NCT02043301). METHODS: Seventy-five adults with low-density lipoprotein cholesterol (LDL-C) ≥130 mg/dL and not on background lipid-lowering therapy were randomized (1:1:1) to a single 150-mg s.c. dose of bococizumab administered to the abdomen, thigh, or upper arm...
June 21, 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28616054/an-investigation-on-non-invasive-fungal-sinusitis-molecular-identification-of-etiologic-agents
#3
Abdolrasoul Mohammadi, Seyed Mostafa Hashemi, Sayed Hamidreza Abtahi, Seyed Mohammad Lajevardi, Sahar Kianipour, Rasoul Mohammadi
BACKGROUND: Fungal sinusitis is increasing worldwide in the past two decades. It is divided into two types including invasive and noninvasive. Noninvasive types contain allergic fungal sinusitis (AFS) and fungus ball. AFS is a hypersensitivity reaction to fungal allergens in the mucosa of the sinonasal tract in atopic individuals. The fungus ball is a different type of noninvasive fungal rhinosinusitis which is delineated as an accumulation of debris and fungal elements inside a paranasal sinus...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/28615428/increased-rate-of-venous-thrombosis-may-be-associated-with-inpatient-dihydroergotamine-treatment
#4
Amy R Tso, Irene R Patniyot, Amy A Gelfand, Peter J Goadsby
OBJECTIVE: To review whether the incidence of catheter-associated venous thromboses was higher in patients receiving IV dihydroergotamine compared to lidocaine. METHODS: We retrospectively reviewed all admissions at the University of California, San Francisco Headache Center from February 25, 2008, through October 31, 2014, for age, sex, diagnosis, aura, treatment dose, type of IV line used, days with line, superficial (SVT) or deep venous thrombosis (DVT), and pulmonary embolism (PE)...
June 14, 2017: Neurology
https://www.readbyqxmd.com/read/28615422/prognostic-factors-for-chronic-headache-a-systematic-review
#5
REVIEW
Katrin Probyn, Hannah Bowers, Fiona Caldwell, Dipesh Mistry, Martin Underwood, Manjit Matharu, Tamar Pincus
OBJECTIVE: To identify predictors of prognosis and trial outcomes in prospective studies of people with chronic headache. METHODS: This was a systematic review of published literature in peer-reviewed journals. We included (1) randomized controlled trials (RCTs) of interventions for chronic headache that reported subgroup analyses and (2) prospective cohort studies, published in English, since 1980. Participants included adults with chronic headache (including chronic headache, chronic migraine, and chronic tension-type headache with or without medication overuse headache)...
June 14, 2017: Neurology
https://www.readbyqxmd.com/read/28603893/allodynia-is-associated-with-initial-and-sustained-response-to-acute-migraine-treatment-results-from-the-american-migraine-prevalence-and-prevention-study
#6
Richard B Lipton, Sagar Munjal, Dawn C Buse, Alix Bennett, Kristina M Fanning, Rami Burstein, Michael L Reed
OBJECTIVE: In a population sample of persons with migraine treating with a single category of acute migraine medication, to identify rates and factors associated with acute treatment outcomes, including 2-hour pain freedom (2hPF), 24-hour pain response (24hPR), and 24-hour sustained pain response (24hSPR). Key predictors include acute treatment type (triptans and other medication categories), the influence of allodynia on response to medication, and the interaction between medication category and presence of allodynia in response to treatment among people with migraine...
June 11, 2017: Headache
https://www.readbyqxmd.com/read/28603429/development-and-validation-of-an-arabic-language-headache-questionnaire-for-population-based-surveys
#7
Naglaa A El-Sherbiny, Hatem Samir Shehata, Hanan Amer, Alaa Elmazny, Mohamed Masoud, Hanan Helmy, Nevin M Shalaby
BACKGROUND: The reported prevalence of headache disorders in Arab regions varies considerably between countries. This may be due to a lack of standardized survey instruments that capture the prevalence. PURPOSE OF THE STUDY: Our goal was to construct and validate a structured headache questionnaire for Arabic-speaking headache patients to be used as an epidemiological survey instrument. METHODS: We developed a culturally adapted interviewer-administered questionnaire in Arabic language comprising two sets of questions...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28598043/clinical-profile-of-hypertensive-emergencies-in-an-intensive-care-unit
#8
Shubhangi V Dhadke, Vithal N Dhadke, Dhruv S Batra
AIMS AND OBJECTIVE: To study the prevalence of hypertensive emergencies in an ICU set up and to study the clinical presentation of hypertensive emergencies related to cardiovascular, neurological and renovascular system. METHODS: Type of Study: Cross-sectional, descriptive study. DURATION OF STUDY: Two years from 1st December 2011 till 30th November 2013. SAMPLE SIZE: 50 patients of hypertensive emergencies admitted to the intensive care unit of Dr...
May 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28597113/headache-in-children-and-dynamic-thiol-disulfide-balance-evaluation-with-a-new-method
#9
Aysegül Nese Citak Kurt, Alperen Aydın, Hatice Demir, Özcan Erel
Headache is one of the most common causes of presentation to the physician in children. We aimed to evaluate the dynamic thiol/disulfide homeostasis with a new method in children with headache and also to investigate the relationship between the headache type, pain severity and duration in our study. We included 40 patients diagnosed with migraine, 40 patients diagnosed with tension-type headache (TTH) and 40 healthy children in the study. No significant difference was found between the total thiol, native thiol, and disulfide levels of the patient and control groups...
June 8, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28589110/citelli-s-abscess-following-otitis-media-a-case-report
#10
Anjan-Kumar Sahoo, Chappity Preetam, Dillip-Kumar Samal, Sourav Sarkar
INTRODUCTION: Citelli's abscess is an extratemporal complication of otitis media. It occurs when pus from the mastoid tip trickles down along the posterior belly of the digastric muscle to the occipital and cervical region. It is a very unusual presenting complication of chronic otitis media with no available data in the until now. CASE REPORT: A 10-year-old female was presented to our outpatient department with a 1 month history of hi-grade fever and headache and pain around the left half of the face...
May 2017: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28587507/adhd-is-comorbid-to-migraine-in-childhood-a-population-based-study
#11
Marco Antônio Arruda, Renato Arruda, Vincenzo Guidetti, Marcelo Eduardo Bigal
OBJECTIVE: Recurrent headaches and ADHD are prevalent in the pediatric population. Herein, we assess if ADHD is comorbid to headaches overall, to headache subtypes (e.g., migraine), and to headache frequency. METHOD: Informed consent and analyzable data were obtained for 5,671 children aged 5 to 12 years (65.9% of the target sample). Parents and teachers were interviewed using validated questionnaires based on the Diagnostic and Statistical Manual of Mental Disorders (5th ed...
June 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/28583000/suicide-in-primary-headaches-in-48-countries-a-physician-survey-based-study
#12
Jose Maria Trejo-Gabriel-Galan, Irene Aicua-Rapún, Esther Cubo-Delgado, Carmen Velasco-Bernal
Aim To investigate the relationship between primary headache types and accomplished or attempted suicide in countries from all world regions. Methods Data were obtained using a questionnaire about suicide due to headache in a face-to-face interview with 203 physicians with expertise in headaches. They came from 48 countries, and from all continents. Results Primary headaches cause one suicide per 1,000,000 population each year (1% of the suicide rate due to all causes). Cluster headache and migraines account for 70-80% of them...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28578816/characteristics-of-headaches-in-japanese-elementary-and-junior-high-school-students-a-school-based-questionnaire-survey
#13
Masahide Goto, Koji Yokoyama, Yasuyuki Nozaki, Koichi Itoh, Ryou Kawamata, Shizuko Matsumoto, Takanori Yamagata
PURPOSE: Few studies have investigated pediatric headaches in Japan. Thus, we examined the lifetime prevalence and characteristics of headaches among elementary and junior high school students in Japan. METHODS: In this school-based study, children aged 6-15years completed a questionnaire based on the diagnostic criteria of the International Classification of Headache Disorders-3β to assess headache characteristics and related disability. RESULTS: Of the 3285 respondents, 1623 (49...
May 31, 2017: Brain & Development
https://www.readbyqxmd.com/read/28578604/does-palliative-chemotherapy-provide-a-palliative-effect-on-symptoms-in-late-palliative-stages-an-interview-study-with-oncologists
#14
Peter Strang, Jenny Bergqvist
BACKGROUND: The possible chemotherapy effects on symptoms in late stages of palliative chemotherapy are seldom registered in clinical practice or investigated as primary outcomes. The aim was therefore to study physicians' opinions and experiences about chemotherapy effects on symptoms. MATERIAL AND METHODS: Thirty-five physicians (mainly oncologists) with variation as regards age, gender and experience were included in a qualitative study with semi-structured interviews...
June 3, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28576330/first-report-of-two-cases-of-cryptococcosis-in-tripoli-libya-infected-with-cryptococcus-neoformans-isolates-present-in-the-urban-area
#15
M S Ellabib, Z A Krema, A A Allafi, M Cogliati
Cryptococcosis is a potentially fatal fungal disease caused by the basidiomycetes yeasts Cryptococcus neoformans and C. gattii with high predilection to invade the central nervous system mainly in immunocompromised hosts. Skin can be secondarily involved in disseminated infection or be exceptionally involved as primary cutaneous infection by inoculation with contaminated materials. We report the first two Libyan cases of cryptococcal meningitis in HIV patients, in which one of them presented a secondary cutaneous involvement due to systemic dissemination...
May 30, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28573720/assessment-of-deep-dynamic-mechanical-sensitivity-in-individuals-with-tension-type-headache-the-dynamic-pressure-algometry
#16
M Palacios-Ceña, K Wang, M Castaldo, Á Guerrero-Peral, A B Caminero, C Fernández-de-Las-Peñas, L Arendt-Nielsen
BACKGROUND: To explore the validity of dynamic pressure algometry for evaluating deep dynamic mechanical sensitivity by assessing its association with headache features and widespread pressure sensitivity in tension-type headache (TTH). METHODS: One hundred and eighty-eight subjects with TTH (70% women) participated. Deep dynamic sensitivity was assessed with a dynamic pressure algometry set (Aalborg University, Denmark(©) ) consisting of 11 different rollers including fixed levels from 500 g to 5300 g...
June 2, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28573246/the-effect-of-body-awareness-therapy-and-aerobic-exercises-on-pain-and-quality-of-life-in-the-patients-with-tension-type-headache
#17
Meral Sertel, Yeşim Bakar, Tülay Tarsuslu Şimşek
BACKGROUND: This study is to investigate the effect of Body Awareness Therapy (BAT) and Aerobic Exercises on pain and quality of life in patients with Tension-Type Headache (TTH). MATERIALS AND METHOD: Sixty individuals with TTH diagnosis who referred Neurologist were incorporated into study. The individuals were randomly grouped into 3 as BAT (n=20), aerobic exercise (n=20) and control group (n=20). Pain severity of the individuals was evaluated by Visual Analog Scale (VAS) and pain diary, disability with ache; by Pain Disability Index (PDI) and Headache Impact Tests (HIT) and quality of life was evaluated by SF-36...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28569554/nsaid-related-upper-gastrointestinal-bleeding-types-of-drug-use-and-patient-profiles-in-real-clinical-practice
#18
Carlos Sostres, Patrica Carrera, Angel Lanas
BACKGROUND: The best available evidence regarding non-steroidal anti-inflammatory drug (NSAID)-related gastrointestinal (GI) bleeding comes from randomized controlled trials including patients who use NSAIDs to manage chronic rheumatic diseases; however, patients with varying background profiles commonly take NSAIDs for many other reasons, often without prescription, and such usage has not been well studied. OBJECTIVES AND METHODS: To define the characteristics of patients hospitalized for upper GI bleeding in clinical practice, we conducted a case-control study among patients with endoscopy-proven major upper GI bleeding due to gastroduodenal peptic lesions and control subjects...
June 1, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28559755/multimodal-chiropractic-care-for-pain-and-disability-in-a-patient-diagnosed-with-ehlers-danlos-syndrome-hypermobility-type-a-case-report
#19
Richard G Strunk
OBJECTIVE: The purpose of this article is to describe the clinical response to multimodal chiropractic treatment of a patient diagnosed with Ehlers-Danlos syndrome, hypermobility type (EDS-HT), and chronic pain. CLINICAL FEATURES: A 22-year-old woman presented with severe chronic neck and low back pain, headaches, and bilateral hand pain and stiffness. In addition to these pain complaints, the patient had a family history of EDS, weekly or daily recurring joint dislocations, and upper and lower extremity joint hypermobility...
June 2017: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/28553881/the-relationship-between-levels-of-plasma-soluble-urokinase-plasminogen-activator-receptor-supar-and-presence-of-migraine-attack-and-aura
#20
Nigar Yılmaz, Mustafa Yılmaz, Burcu Sirin, Sureyya Yılmaztekin, Gülnihal Kutlu
Migraine is one of the most common types of pain associated with sterile inflammatory conditions. Soluble urokinase plasminogen activator receptor (suPAR) is a potential novel inflammatory marker. We aim to determine the association between serum values of suPAR, procalcitonin, fibrinogen, and high-sensitivity C-reactive protein (hs-CRP) and migraine disease characteristics. The study involved a total of 60 migraine patients (33 patients in the interictal period, 27 patients in the attack period) and 30 healthy individuals...
May 29, 2017: Journal of Receptor and Signal Transduction Research
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