Yangyi Liu, Jingjing Li, Yi Zhang, Fan Wang, Juanjuan Su, Chao Ma, Shuyi Zhang, Yanan Du, Chunhai Fan, Hongjie Zhang, Kai Liu
Cell mechanotransduction signals are important targets for physical therapy. However, current physiotherapy heavily relies on ultrasound, which is generated by high-power equipment or amplified by auxiliary drugs, potentially causing undesired side effects. To address current limitations, a robotic actuation-mediated therapy is developed that utilizes gentle mechanical loads to activate mechanosensitive ion channels. The resulting calcium influx precisely regulated the expression of recombinant tumor suppressor protein and death-associated protein kinase, leading to programmed apoptosis of cancer cell line through caspase-dependent pathway...
March 21, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)