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https://www.readbyqxmd.com/read/29033240/single-nucleotide-polymorphisms-in-the-acylphosphatase-2-gene-and-the-snp-snp-interactions-on-the-risk-of-breast-cancer-in-chinese-han-women
#1
Junben Wu, Shujing Wang, Fanglan Liu, Shuluan Li
INTRODUCTION: The purpose of this study was to investigate the impact of single nucleotide polymorphisms (SNPs) in the acylphosphatase 2 gene and the SNP-SNP interactions on breast cancer (BC) risk in Chinese Han women. PATIENTS AND METHODS: A logistic regression model was used to examine the association between SNPs and BC risk. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated. Generalized multifactor dimensionality reduction was employed to analyze the SNP-SNP interaction...
September 19, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29030160/mobile-application-vs-paper-pictorial-blood-assessment-chart-to-track-menses-in-young-women-a-randomized-cross-over-design
#2
Amanda E Jacobson, Sara K Vesely, Fareeda Haamid, Myra Christian-Rancy, Sarah H O'Brien
BACKGROUND: /Objectives: Heavy menstrual bleeding is a common complaint reported by approximately 30% of women. The Pictorial Blood Assessment Chart (PBAC) score is often used to quantify severity of menstrual bleeding. However, the traditional PBAC paper diary may be subject to recall bias and compliance issues, especially in adolescents. We developed a mobile application (app) version of the PBAC score and evaluated patient satisfaction and compliance with app reporting vs paper reporting...
October 10, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/29030159/obstructive-m%C3%A3-llerian-anomalies-in-menstruating-adolescent-girls-a-report-of-22-cases
#3
Karina Kapczuk, Zbigniew Friebe, Kinga Iwaniec, Witold Kędzia
STUDY OBJECTIVE: To assess the clinical course of obstructive Müllerian anomalies found in girls after menarche DESIGN: A retrospective case series of adolescents who between 2009 and 2016 were treated for vaginal or uterine obstructive malformations diagnosed after menarche SETTING: Division of Gynecology, Poznań University of Medical Sciences, Poznań, Poland PARTICIPANTS: Twenty-two patients who, at the age of 11.4-18.2 (median 13.1) years, between 2 and 74 (median 7.5) months after menarche, underwent surgical repair of obstructive genital anomaly MAIN OUTCOME MEASURES: Müllerian defect type, presentation, radiologic findings, pre- and postoperative course RESULTS: Eighteen patients (81...
October 10, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/29028521/age-at-menarche-and-depressive-symptoms-in-older-southern-chinese-women-a-mendelian-randomization-study-in-the-guangzhou-biobank-cohort-study
#4
Shiu Lun Au Yeung, Chaoqiang Jiang, Kar Keung Cheng, Lin Xu, Weisen Zhang, Tai Hing Lam, Gabriel Matthew Leung, C Mary Schooling
To clarify the causal role of age at menarche in depressive symptoms we conducted a Mendelian randomization study using a large Southern Chinese cohort (n = 12,233). A genetic allele score was derived using stepwise regression with cross validation. Older age at menarche was not associated with geriatric depression scale score. Our findings suggest that higher rates of depression in women are likely attributable to other factors which require investigation.
September 19, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29026748/knowledge-and-awareness-regarding-menstruation-and-hiv-aids-among-schoolgoing-adolescent-girls
#5
Rakhi Jain, Puneet Anand, Anuj Dhyani, Deshant Bansal
INTRODUCTION: Menstruation in our country is associated with various myths and restrictions leading to lack of awareness among adolescent girls. Insufficient menstrual hygiene practices are the cause of stress associated with menstruation and reproductive tract infections. Sexually transmitted infections and HIV/AIDS are not openly discussed in our society making adolescents vulnerable to them. AIM: To assess the knowledge of school going adolescent girls regarding menstrual hygiene and HIV/AIDS...
January 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29023494/pooled-analysis-of-menstrual-irregularities-from-three-major-clinical-studies-evaluating-everolimus-for-the-treatment-of-tuberous-sclerosis-complex
#6
Steven Sparagana, David N Franz, Darcy A Krueger, John J Bissler, Noah Berkowitz, Karin Burock, J Christopher Kingswood
OBJECTIVES: To determine the impact of everolimus on female fertility, including menstrual irregularities, secondary amenorrhea, and luteinizing and follicle stimulating hormone levels in female patients. DESIGN: A pooled analysis from 3 prospective studies consisting of a core phase (≥6 months) and a long-term follow-up open-label extension. SETTING: One phase 2 single-center and two phase 3 multicenter studies. PARTICIPANTS: Data were obtained from female participants, restricted to those between 10 and 55 years of age, during 1 of 3 of the described clinical trials of everolimus...
2017: PloS One
https://www.readbyqxmd.com/read/29020129/maternal-pre-pregnancy-bmi-gestational-weight-gain-and-daughter-s-age-at-menarche-the-avon-longitudinal-study-of-parents-and-children
#7
Rebecca B Lawn, Debbie A Lawlor, Abigail Fraser
Earlier puberty and menarcheal age are associated with adverse health outcomes. Reported associations of maternal adiposity with daughters' menarcheal age are inconsistent. We examined associations between maternal pre-pregnancy body mass index (BMI) and gestational weight gain (GWG), and daughters' age at menarche (n = 3,935), pubarche (Tanner stage 2 for pubic hair) and thelarche (Tanner stage 2 for breast development) (n = 2,942) in the Avon Longitudinal Study of Parents and Children, a UK prospective pregnancy cohort (baseline 1991-1992)...
September 11, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28989924/epithelial-ovarian-tumors-in-a-premenarchal-girl-a-rare-case-report
#8
Pushpanjali Ojha, Jitendra Singh Nigam, Archana Hemant Deshpande, Chitrawati Bal Gargade
Ovarian tumors are relatively uncommon in paediatric age group and mostly occur in the period after menarche and are extremely rare prior to menarche. However, in children and adolescent, the epithelial ovarian tumors account approximately 10% to 28% of all ovarian tumors. In the present case, the patient was presented with abdominal pain for 1 day and no mass was felt on physical examination. Contrast-enhance computed tomography abdomen and pelvis showed a left ovarian cystic mass measuring 7.3×5.1 cm in size and unilateral oophorectomy was done...
September 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28977777/omega-3-polyunsaturated-fatty-acid-docosahexaenoic-acid-and-its-role-in-exhaustive-exercise-induced-changes-in-female-rat-ovulatory-cycle
#9
Abeer F Mostafa, Shereen M Samir, Reham M Nagib
INTRODUCTION: Exhaustive exercises can cause delayed menarche or menstrual cycle irregularities in female. Omega-3 polyunsaturated fatty acids (ω-3 PUFAs) are incorporated into a wide range of benefits in many physiological systems. AIM OF WORK: aimed to assess the role of ω-3 PUFA docosahexaenoic acid (DHA) on the deleterious effects of exhaustive exercise on female reproductive system in rats. MATERIALS AND METHODS: virgin female rats were randomly divided into four groups (12 rats in each): Control group (C), Omega 3 (ω-3) group treated with DHA, exhaustive exercise group (Ex), and exhaustive exercised rats treated with DHA...
October 4, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28977577/early-menarche-and-blood-pressure-in-adulthood-systematic-review-and-meta-analysis
#10
S Bubach, C Loret De Mola, R Hardy, J Dreyfus, A C Santos, B L Horta
Background: It has been reported that early menarche is associated with high blood pressure and hypertension. However, some studies have failed to observe such association. We carried out a systematic review and meta-analysis on the association of early menarche with hypertension and high blood pressure in adulthood. Methods: PUBMED, SciELO, Scopus and LILACS databases were searched. Studies that evaluated the association of early menarche with hypertension or high blood pressure, among women aged 20 years or more were included...
September 11, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/28974739/age-at-menarche-and-prevalence-of-preterm-birth-results-from-the-healthy-baby-cohort-study
#11
Hui Li, Lulu Song, Lijun Shen, Bingqing Liu, Xiaoxuan Zheng, Lina Zhang, Yuanyuan Li, Wei Xia, Bin Lu, Bin Zhang, Aifen Zhou, Zhongqiang Cao, Youjie Wang, Shunqing Xu
Little is known about the impact of age at menarche on preterm birth. The aim of this study was to examine the association between age at menarche and preterm birth. A total of 11,016 Chinese women who gave birth to live singleton infants were recruited from the Healthy Baby Cohort between 2012 and 2014 in the province of Hubei, China. Age at menarche was reported via face-to-face interviews and was categorized into five groups (≤11, 12, 13, 14 and ≥15 years). Gestational age was estimated using maternal last menstrual period...
October 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28972310/genetic-variation-in-the-progesterone-receptor-gene-and-susceptibility-to-recurrent-pregnancy-loss-a-case-control-study
#12
Wael Bahia, Ramzi R Finan, Mariam Al-Mutawa, Anis Haddad, Aymen Soua, Faouzi Janhani, Touhami Mahjoub, Wassim Y Almawi
OBJECTIVE: To investigate the association of progesterone receptor (PGR) gene variants with the susceptibility to recurrent pregnancy loss (RPL). DESIGN: Retrospective case-control study. SETTING: Outpatient obstetrics/gynecology clinics. POPULATION: Women with RPL (396), defined as ≥3 consecutive miscarriages of unknown etiology, and 361 control women. METHODS: PGR genotyping was done by allelic exclusion method (real-time PCR)...
October 3, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28970854/the-effect-of-reproductive-factors-on-breast-cancer-presentation-in-women-who-are-brca-mutation-carrier
#13
Ju-Yeon Kim, Hyeong-Gon Moon, Young-Joon Kang, Wonshik Han, Woo-Chul Noh, Yongsik Jung, Byung-In Moon, Eunyoung Kang, Sung-Shin Park, Min Hyuk Lee, Bo Young Park, Jong Won Lee, Dong-Young Noh
PURPOSE: Germline mutations in the BRCA1 and BRCA2 genes confer increased risks for breast cancers. However, the clinical presentation of breast cancer among women who are carriers of the BRCA1 or BRCA2 (BRCA1/2 carriers) mutations is heterogenous. We aimed to identify the effects of the reproductive histories of women with the BRCA1/2 mutations on the clinical presentation of breast cancer. METHODS: We retrospectively analyzed clinical data on women with proven BRCA1 and BRCA2 mutations who were recruited to the Korean Hereditary Breast Cancer study, from 2007 to 2014...
September 2017: Journal of Breast Cancer
https://www.readbyqxmd.com/read/28970852/clinicopathologic-characteristics-of-pregnancy-associated-breast-cancer-results-of-analysis-of-a-nationwide-breast-cancer-registry-database
#14
Yun Gyoung Kim, Ye Won Jeon, Byung Kyun Ko, Guiyun Sohn, Eun-Kyu Kim, Byung-In Moon, Hyun Jo Youn, Hyun-Ah Kim
PURPOSE: This study aimed to evaluate the clinicopathological characteristics of pregnancy-associated breast cancer (PABC) in comparison with non-pregnancy associated breast cancer (non-PABC). METHODS: A total of 344 eligible patients with PABC were identified in the Korean Breast Cancer Society Registry database. PABC was defined as ductal carcinoma in situ, invasive ductal carcinoma, or invasive lobular carcinoma diagnosed during pregnancy or within 1 year after the birth of a child...
September 2017: Journal of Breast Cancer
https://www.readbyqxmd.com/read/28963633/there-is-no-association-between-vitamin-d-status-and-characteristics-of-central-precocious-puberty-in-girls
#15
Gwénaëlle Duhil de Bénazé, Raja Brauner, Jean-Claude Souberbielle
Vitamin D deficiency has been associated with several pathologies in humans and has recently been linked to idiopathic central precocious puberty in girls. We evaluated this potential link in a retrospective study. Among 493 girls with idiopathic central precocious puberty previously described, we selected 145 girls for whom a plasma sample at the initial evaluation was available to determine the concentration of 25OHD and 1,25(OH)2D. We analyzed the correlation between different puberty characteristics (BMI, growth rate the year before the onset of puberty, bone age, LH and FSH peaks, LH/FSH peak ratio, and estradiol concentration) and the concentration of 25OHD and 1,25(OH)2D...
September 29, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28962650/developing-a-risk-prediction-model-for-breast-cancer-a-statistical-utility-to-determine-affinity-of-neoplasm-sudan-ca-breast
#16
Alaaddin M Salih, Dafallah M Alam-Elhuda, Musab M Alfaki, Adil E Yousif, Momin M Nouradyem
BACKGROUND: Breast cancer risk prediction models are widely used in clinical settings. Although most of the well-known models were designed based on data collected from western population, yet they have been utilized for surveillance purposes in many limited-resource countries. Given the genetic variations in risk factors that exist between different races, we therefore aimed to develop and validate a tool for breast cancer risk assessment among Sudanese women. METHODS: Using cross-sectional design, 153 subjects were eligible to participate in our study...
September 29, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/28960803/clinical-report-warsaw-breakage-syndrome-with-small-radii-and-fibulae
#17
Sarah Eppley, Robert J Hopkin, Bryce Mendelsohn, Anne M Slavotinek
We present two new cases of Warsaw Breakage Syndrome (WABS), an autosomal recessive cohesinopathy, in sisters aged 13 and 11 years who both had compound heterozygous mutations in DDX11. After exclusion of Fanconi anemia, Bloom syndrome and Nijmegen breakage syndrome, whole exome sequencing revealed two novel variants-c.1523T>G, predicting (p.Leu508Arg) and c.1949-1G>A (IVS19-1G>A), that were confirmed with Sanger sequencing in both affected individuals. DDX11 encodes an iron-sulfur-containing DNA helicase, and mutations in this gene have been reported in the five WABS cases previously identified to date...
September 28, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28960326/birth-weight-and-prepubertal-body-size-predict-menarcheal-age-in-india-peru-and-vietnam
#18
Elisabetta Aurino, Whitney Schott, Mary E Penny, Jere R Behrman
Evidence on the associations of birth weight and prepubertal nutritional status with menarcheal age for low- and middle-income countries is limited. We investigated these relationships using the Young Lives younger cohort for 2001 Indian, Peruvian, and Vietnamese girls born in 2001-2002. Girls were followed at approximately ages 1, 5, 8, and 12 years. Weibull survival models estimated hazards of earlier menarche on the basis of birth weight Z-scores (BWZ), and age-8 BMI-for-age Z-scores (BMIZ) and height-for-age Z-scores (HAZ)...
September 28, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28959377/higher-prevalence-of-clinical-cardiovascular-comorbidities-in-postmenopausal-women-with-self-reported-premenopausal-hirsutism-and-or-oligo-amenorrhea
#19
F V Comim, C S Wippel, R M Copês, F W Langer, J M Carvalho, R N Moresco, M O Premaor
Hirsutism is a common condition, being present in about 5-15% of women. It is characterized by the growth of terminal hair in a pattern typical for men, like as hair growth in upper lip, chin, cheek and lower and upper abdomen. Not infrequently, hirsutism is followed by other signs of hyerandrogenism such as alopecia, acne, and seborrhea. The current study evaluated the association between a self-reported history of hirsutism and oligo-amenorrhea during reproductive age and the presence of several comorbidities in women after menopause...
2017: Dermato-endocrinology
https://www.readbyqxmd.com/read/28958167/age-at-menarche-and-the-risk-of-operative-delivery
#20
Hsu Phern Chong, J Frederik Frøen, Sylvia Richardson, Benoit Liquet, D Stephen Charnock-Jones, Gordon C S Smith
OBJECTIVES: We sought to evaluate the impact of later menarche on the risk of operative delivery. POPULATION: We studied 38,069 eligible women (first labors at term with a singleton infant in a cephalic presentation) from the Norwegian Mothers and Child Cohort Study. The main exposures were the age at menarche and the duration of the interval between menarche and the first birth. METHODS: Poisson's regression with a robust variance estimator...
September 28, 2017: Journal of Maternal-fetal & Neonatal Medicine
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