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https://www.readbyqxmd.com/read/29235933/faster-ticking-rate-of-the-epigenetic-clock-is-associated-with-faster-pubertal-development-in-girls
#1
Alexandra M Binder, Camila Corvalan, Verónica Mericq, Ana Pereira, José Luis Santos, Steve Horvath, John Shepherd, Karin B Michels
Epigenetic age is an indicator of biological aging, capturing the impact of environmental and behavioral influences across time on cellular function. Deviance between epigenetic age and chronological age (AgeAccel) is a predictor of health. Pubertal timing has similarly been associated with cancer risk and mortality rate among females. We examined the association between AgeAccel and pubertal timing and adolescent breast composition in the longitudinal Growth and Obesity Cohort Study. AgeAccel was estimated in whole blood using the Horvath method at breast Tanner 2 (B2) and 4 (B4)...
December 13, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/29228056/back-and-neck-pain-and-function-in-females-with-adolescent-idiopathic-scoliosis-a-follow-up-at-least-23-years-after-conservative-treatment-with-a-milwaukee-brace
#2
Ewa Misterska, Jakub Głowacki, Adam Okręt, Maria Laurentowska, Maciej Głowacki
We aimed to explore the long-term outcomes of back and neck pain and functionality in adult females with adolescent idiopathic scoliosis (AIS), who had been treated with a Milwaukee brace, in a follow-up study a minimum of 23 years after the completion of the treatment, using radiological, clinical and socio-demographical data. Thirty AIS patients (scoliosis group-SG), were included in the study based on an extensive search of Pediatric Orthopedics and Traumatology Clinic charts. All treatments were successfully completed between 1974 and 1990...
2017: PloS One
https://www.readbyqxmd.com/read/29225941/beyond-menstrual-hygiene-addressing-vaginal-bleeding-throughout-the-life-course-in-low-and-middle-income-countries
#3
REVIEW
Marni Sommer, Penelope A Phillips-Howard, Therese Mahon, Sasha Zients, Meredith Jones, Bethany A Caruso
Girls and women experience numerous types of vaginal bleeding. These include healthy reproductive processes, such as menstruation and bleeding after childbirth, but also bleeding related to health conditions, such as fibroids or cancer. In most societies, the management of menstruation is handled covertly, something girls are often instructed about at menarche. The management of other vaginal bleeding is often similarly discreet, although behaviours are not well documented. In many societies, cultural taboos frequently hinder open discussion around vaginal bleeding, restricting information and early access to healthcare...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29214820/weight-management-behaviors-among-mexican-american-youth-cross-sectional-variation-by-timing-of-growth-and-maturation
#4
Jennifer L Gay, Eva V Monsma, Katie Darby Hein
PURPOSE: To assess the association between growth and maturation with weight management behaviors (WMBs) among Mexican American youth. DESIGN: A cross-sectional design was used to measure timing of growth and maturation as well as WMBs. SAMPLE: Students were recruited through physical education classes in south Texas schools. The sample included 623 participants (52.3% female; 49.8% with weight ≥85th percentile) in grades 4 through 12. Students in middle school were purposely oversampled to examine questions around timing of growth and maturation...
January 1, 2017: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/29211180/factors-associated-with-first-sexual-intercourse-among-mothers-with-14-16-years-of-age-from-porto-alegre-rs-brazil
#5
Mara Cristiany Rodrigues Spinola, Jorge Umberto Béria, Lígia Braun Schermann
This study analyzed the factors associated with first sexual intercourse among 427 mothers with 14-16 years of age from Porto Alegre (RS), Brazil. Data on adolescent socio-demographic status (skin color, religion and schooling gap) and reproductive aspects (age at menarche, age at first sexual intercourse, partnership in first sexual intercourse and partner's age) were collected through household survey. Data analysis was performed using bivariate and multivariate analysis through Poisson regression with robust variance...
November 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/29207971/comparison-of-the-association-of-mammographic-density-and-clinical-factors-with-ductal-carcinoma-in-situ-versus-invasive-ductal-breast-cancer-in-korean-women
#6
Hyeonyoung Ko, Jinyoung Shin, Jeong Eon Lee, Seok Jin Nam, Tuong Linh Nguyen, John Llewelyn Hopper, Yun-Mi Song
BACKGROUND: In spite of the increasing incidence of in situ breast cancer, the information about the risk factors of in situ breast cancer (DCIS) is scarce as compared to the information available for invasive ductal breast cancer (IDC), with inconsistent findings regarding the difference in risk factors between DCIS and IDC. METHODS: We enrolled 472 women with IDC and 90 women with DCIS and 1088 controls matching for age and menopausal status. Information on risk factors was collected through self-administered questionnaire...
December 5, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29206842/from-menarche-to-menopause-a-population-based-assessment-of-water-sanitation-and-hygiene-risk-factors-for-reproductive-tract-infection-symptoms-over-life-stages-in-rural-girls-and-women-in-india
#7
Kelly K Baker, Bijaya Padhi, Belen Torondel, Padmalaya Das, Ambarish Dutta, Krushna Chandra Sahoo, Bhabani Das, Robert Dreibelbis, Bethany Caruso, Matthew C Freeman, Lauren Sager, Pinaki Panigrahi
Women face greater challenges than men in accessing water, sanitation, and hygiene (WASH) resources to address their daily needs, and may respond to these challenges by adopting unsafe practices that increase the risk of reproductive tract infections (RTIs). WASH practices may change as women transition through socially-defined life stage experiences, like marriage and pregnancy. Thus, the relationship between WASH practices and RTIs might vary across female reproductive life stages. This cross-sectional study assessed the relationship between WASH exposures and self-reported RTI symptoms in 3,952 girls and women from two rural districts in India, and tested whether social exposures represented by reproductive life stage was an effect modifier of associations...
2017: PloS One
https://www.readbyqxmd.com/read/29204256/reproductive-disturbances-among-saudi-adolescent-girls-and-young-women-with-type-1-diabetes-mellitus
#8
Rim Braham, Asirvatham Alwin Robert, Maha Ali Musallam, Abdulaziz Alanazi, Nawaf Bin Swedan, Mohamed Abdulaziz Al Dawish
AIM: To identify reproductive disturbances among adolescent girls and young women with type 1 diabetes mellitus (T1DM) in Saudi Arabia. METHODS: This cross sectional study was conducted among 102 female with T1DM, (aged 13-29 years) who attended the Diabetes Clinic at Diabetes Treatment Center, Prince Sultan Military Medical City, Saudi Arabia between April 2015 to March 2016. Clinical history, anthropometric characteristics and reproductive disturbance were collected through a questionnaire...
November 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/29200174/predictability-of-supine-radiographs-for-determining-in-brace-correction-for-adolescent-idiopathic-scoliosis
#9
Jason Pui Yin Cheung, Karen Kar Lum Yiu, Srinivasa Vidyadhara, Peggy Pui Yee Chan, Prudence Wing Hang Cheung, Kin Cheung Mak
STUDY DESIGN: Retrospective radiographic study OBJECTIVE.: To assess whether flexibility as revealed by the supine radiograph, predicts in-brace curve correction. SUMMARY OF BACKGROUND DATA: Currently there is no consensus regarding a standard method to assess curve flexibility and immediate brace effectiveness in treating adolescent idiopathic scoliosis (AIS). Brace fabrication methods may be variable but ideally it should achieve maximal curve correction. Curve flexibility governs the degree of curve correction in-brace and hence dynamic radiographs are commonly performed prior to brace fitting...
December 1, 2017: Spine
https://www.readbyqxmd.com/read/29199923/micronutrient-status-in-middle-childhood-and-age-at-menarche-results-from-the-bogot%C3%A3-school-children-cohort
#10
Eduardo Villamor, Constanza Marín, Mercedes Mora-Plazas, Henry Oliveros
Childhood intake of animal foods is associated with age at first menstrual period (menarche). It is unknown whether the micronutrients present in these foods could explain this association. Our objective was to investigate the associations of micronutrient status biomarkers in middle childhood with age at menarche. We quantified circulating Hb, ferritin, mean corpuscular volume, Zn, vitamin B12, erythrocyte folate and retinol in 1464 pre-menarcheal girls aged 5-12 years in Bogotá, Colombia, and followed them for a median 5·7 years for the occurrence and date of menarche...
December 4, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/29199184/home-based-vibration-assisted-exercise-as-a-new-treatment-option-for-scoliosis-a-randomised-controlled-trial
#11
S Langensiepen, C Stark, R Sobottke, O Semler, J Franklin, M Schraeder, J Siewe, P Eysel, E Schoenau
OBJECTIVES: The aim of this study was to evaluate the effect of scoliosis specific exercises (SSE) on a side-alternating whole body vibration platform (sWBV) as a home-training program in girls with adolescent idiopathic scoliosis (AIS). METHODS: 40 female AIS patients (10-17 years) wearing a brace were randomly assigned to two groups. The intervention was a six months, home-based, SSE program on a sWBV platform five times per week. Exercises included standing, sitting and kneeling...
December 1, 2017: Journal of Musculoskeletal & Neuronal Interactions
https://www.readbyqxmd.com/read/29197760/lifetime-exposure-to-ambient-air-pollution-and-methylation-of-tumor-suppressor-genes-in-breast-tumors
#12
Catherine L Callahan, Matthew R Bonner, Jing Nie, Daikwon Han, Youjin Wang, Meng-Hua Tao, Peter G Shields, Catalin Marian, Kevin H Eng, Maurizio Trevisan, Jan Beyea, Jo L Freudenheim
BACKGROUND: We previously reported increased risk of breast cancer associated with early life exposure to two measures of air pollution exposure, total suspended particulates (TSP) and traffic emissions (TE), possible proxies for exposure to polycyclic aromatic hydrocarbons (PAHs). Exposure to PAHs has been shown to be associated with aberrant patterns of DNA methylation in peripheral blood of healthy individuals. Exposure to PAHs and methylation in breast tumor tissue has received little attention...
November 30, 2017: Environmental Research
https://www.readbyqxmd.com/read/29197239/age-at-menarche-in-polish-university-students-born-before-during-and-after-world-war-ii-economic-effects
#13
Grażyna Liczbińska, Zbigniew Czapla, Janusz Piontek, Robert M Malina
Although the relationships between economic conditions and biological variables over the past two centuries in Poland are reasonably well-documented, the influence of economic and political disruptions, including nutritional privation, during the years immediately before, during and shortly after World War II (WWII) has received less attention. This paper considers the association between age at menarche and body size of university students born before, during and after WWII and father's level of education, a commonly used indicator of family economic status in Poland...
November 21, 2017: Economics and Human Biology
https://www.readbyqxmd.com/read/29196492/high-fat-diet-exposure-from-pre-pubertal-age-induces-pcos-in-rats
#14
Roshni S Patel, Gaurang B Shah
Polycystic ovary syndrome (PCOS) is associated with hyperandrogenism, oligo-anovulation, polycystic ovaries and metabolic syndrome. Many researchers reported that PCOS often starts with menarche in adolescents. Presently available animal models focuses on ovarian but not metabolic features of PCOS. Therefore, we hypothesized that high fat diet feeding to pre-pubertal female rats results in both reproductive and metabolic features of PCOS. Pre-pubertal female rats were divided into two groups: group I received normal pellet diet and group II received high fat diet (HFD)...
December 1, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29193533/living-conditions-and-change-in-age-of-menarche-in-adult-maya-mothers-and-daughters-from-yucatan-mexico
#15
Hugo Azcorra, Luis Rodríguez, Sudip Datta Banik, Barry Bogin, Federico Dickinson, Maria Ines Varela-Silva
OBJECTIVES: To analyze whether living conditions, experienced by mothers and adult daughters during their childhood, are associated with age at menarche (AAM) in daughters. METHODS: From September, 2011, to January, 2014, AAM and childhood living conditions were collected from a sample of 246 dyads of Maya mothers (mean age = 59.60 years, SD = 8.64) and their adult daughters (mean age = 33.03 years, SD = 5.57) from the cities of Merida and Motul in Yucatan, Mexico...
November 27, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/29190387/chronic-hyperandrogenemia-in-the-presence-and-absence-of-a-western-style-diet-impairs-ovarian-and-uterine-structure-function-in-young-adult-rhesus-monkeys
#16
Cecily V Bishop, Emily C Mishler, Diana L Takahashi, Taylor E Reiter, Kise R Bond, Cadence A True, Ov D Slayden, Richard L Stouffer
STUDY QUESTION: Does chronic hyperandrogenemia beginning at menarche, in the absence and presence of a western-style diet (WSD), alter ovarian and uterine structure-function in young adult rhesus monkeys? SUMMARY ANSWER: Phenotypic alterations in ovarian and uterine structure/function were induced by exogenous testosterone (T), and compounded in the presence of a WSD (T+WSD). WHAT IS KNOWN ALREADY: Hyperandrogenemia is a well-established component of PCOS and is observed in adolescent girls, indicating a potential pubertal onset of disease symptoms...
November 28, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29184806/polycystic-ovary-syndrome-in-adolescence-diagnostic-and-therapeutic-strategies
#17
REVIEW
Manmohan K Kamboj, Andrea E Bonny
Controversy continues about the underlying etiopathogenesis, diagnostic criteria, and recommendations for polycystic ovary syndrome (PCOS) in adolescents. Recent literature has recognized these deficiencies and evidence based expert recommendations have become more available. The purpose of this chapter is to offer primary care providers a practical understanding and approach to the diagnosis and treatment of PCOS in adolescents. Although the presence of polycystic ovary morphology (PCOM) is included as a key diagnostic criterion of PCOS in adults, it is currently not recommended for the diagnosis in adolescents...
October 2017: Translational pediatrics
https://www.readbyqxmd.com/read/29174167/progress-in-the-diagnosis-and-management-of-adolescent-endometriosis-an-opinion
#18
REVIEW
Giuseppe Benagiano, Sun-Wei Guo, Patrick Puttemans, Stephan Gordts, Ivo Brosens
Increasing evidence indicates that early onset endometriosis (EOE), starting around menarche or early adolescence, may have an origin different from the adult variant, originating from neonatal uterine bleeding (NUB). This implies seeding of naïve endometrial progenitor cells into the pelvic cavity with NUB; these can then activate around thelarche. It has its own pathophysiology, symptomatology and risk factors, warranting critical management re-evaluation. It can also be progressive, endangering future reproductive capacity...
October 25, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29172285/body-mass-index-and-breast-cancer-risk-among-thai-premenopausal-women-a-case-control-study
#19
Wisit Chaveepojnkamjorn, Rungsinoppadol Thotong, Pratana Sativipawee, Supachai Pitikultang
Background: Breast cancer (BC) is the leading malignancy in women with high incidence and mortality worldwide. Obesity is one of several established risk factors for chronic diseases including cancer. The objective of this research was to determine the association of body mass index (BMI) with BC among Thai premenopausal women (TPW). Materials and Methods: A case-control study was conducted among TPW attending the National Cancer Institute in Bangkok, with 257 cases and 257 controls in 2013-2014. Cases and controls were matched by age (± 5 years), residential area and duration of attending...
November 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29172267/breast-cancer-risk-assessment-using-the-gail-model-and-it%C3%A2-s-predictors-in-saudi-women
#20
Hala Hazam Al Otaibi
Background: The Gail Model has been widely implemented in developed and developing countries and is considered to be the best available instrument to estimate breast cancer (BC) risk for early prevention. Objective: The goals of the study were to determine five-year and lifetime BC risks and to assess BC predictors among female Saudi teachers using the Gail model. Methods: A cross sectional study with convenience sampling was conducted among 180 female Saudi secondary school teachers. The Gail model was used to evaluate the five-year and lifetime risks of developing BC...
November 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
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