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https://www.readbyqxmd.com/read/28719421/lifelong-estradiol-exposure-and-risk-of-depressive-symptoms-during-the-transition-to-menopause-and-postmenopause
#1
Wendy K Marsh, Joyce T Bromberger, Sybil L Crawford, Katherine Leung, Howard M Kravitz, John F Randolph, Hadine Joffe, Claudio N Soares
OBJECTIVE: Depression risk increases during the menopausal transition (MT) and initial postmenopausal years-both times of significant fluctuations of estrogen. Research to date provides limited support for the hypothesis that estrogen fluctuations play a role in the greater susceptibility to midlife depression. Importantly, not all women report depressive symptoms during the MT, and recent reports suggest that duration of exposure to estradiol throughout the adult years may also play a role in vulnerability to depression...
July 17, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28716824/secular-trend-of-age-at-menarche-in-chinese-adolescents-born-from-1973-to-2004
#2
Xin Meng, Suyun Li, Wenhou Duan, Yanxin Sun, Chongqi Jia
OBJECTIVES: To estimate secular trend and factors influencing the age at menarche for Chinese girls born from 1973 to 2004. METHODS: Data were collected from the China Health and Nutrition Survey, a prospective open cohort and an ongoing nationwide health and nutrition survey, consisting of 3199 apparently healthy Chinese girls aged 6 to 18 years at entry from 1991 to 2011. Average age at menarche and its 95% confidence interval were estimated by weighted means of Kaplan-Meier survival analysis...
July 18, 2017: Pediatrics
https://www.readbyqxmd.com/read/28710506/obese-versus-normal-weight-late-adolescent-females-have-inferior-trabecular-bone-microarchitecture-a-pilot-case-control-study
#3
Joseph M Kindler, Norman K Pollock, Hannah L Ross, Christopher M Modlesky, Harshvardhan Singh, Emma M Laing, Richard D Lewis
Though still a topic of debate, the position that skeletal health is compromised with obesity has received support in the pediatric and adult literature. The limited data relating specifically to trabecular bone microarchitecture, however, have been relatively inconsistent. The aim of this pilot cross-sectional case-control study was to compare trabecular bone microarchitecture between obese (OB) and normal-weight (NW) late-adolescent females. A secondary aim was to compare diaphyseal cortical bone outcomes between these two groups...
July 14, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28705605/age-of-menarche-is-associated-with-knee-joint-replacement-due-to-primary-osteoarthritis-the-hunt-study-and-the-norwegian-arthroplasty-register
#4
A I Hellevik, L Nordsletten, M B Johnsen, A M Fenstad, O Furnes, K Storheim, J A Zwart, G Flugsrud, A Langhammer
OBJECTIVE: To investigate whether parity, age at menarche, menopausal status, age at menopause, use of oral contraceptives (OC) or use of hormone replacement therapy (HRT) were associated with total knee replacement (TKR) or total hip replacement (THR) due to primary osteoarthritis. METHOD: In a prospective cohort study of 30,289 women from the second and third surveys of the Nord-Trøndelag Health Study, data were linked to the Norwegian Arthroplasty Register (NAR) in order to identify TKR or THR due to primary osteoarthritis...
July 10, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28704413/association-of-insulin-resistance-with-near-peak-bone-mass-in-the-femur-and-lumbar-spine-of-korean-adults-aged-25-35-the-korean-national-health-and-nutrition-examination-survey-2008-2010
#5
Min Soo Choo, Se Rin Choi, Jun Hyun Han, Seong Ho Lee, Young Suk Shim
OBJECTIVE: This study aimed to evaluate the relationship between insulin resistance and the bone mineral density (BMD) of femur and lumbar spine in Korean adults who are expected to exhibit near peak bone mass. METHODS: Data from the Korean National Health and Nutrition Examination Survey 2008-2010 were analyzed. A total of 2,750 participants aged 25-35 years were included. Insulin resistance was assessed using a homeostatic model assessment of insulin resistance (HOMA-IR) and serum fasting insulin...
2017: PloS One
https://www.readbyqxmd.com/read/28701499/breastfeeding-ovulatory-years-and-risk-of-multiple-sclerosis
#6
Annette Langer-Gould, Jessica B Smith, Kerstin Hellwig, Edlin Gonzales, Samantha Haraszti, Corinna Koebnick, Anny Xiang
OBJECTIVE: To determine whether women who breastfeed their infants longer or have fewer ovulatory years are at lower risk of developing multiple sclerosis (MS). METHODS: We recruited women with newly diagnosed MS or its precursor, clinically isolated syndrome (CIS) (n = 397), and matched controls (n = 433) into the MS Sunshine Study from the membership of Kaiser Permanente Southern California. A structured in-person questionnaire was administered to collect the behavioral (pregnancies, breastfeeding, hormonal contraceptive use) and biological (age at menarche and menopause, amenorrhea) factors to make up ovulatory years...
July 12, 2017: Neurology
https://www.readbyqxmd.com/read/28698185/age-at-menarche-and-late-adolescent-adiposity-associated-with-mammographic-density-on-processed-digital-mammograms-in-24-840-women
#7
Stacey E Alexeeff, Nnaemeka Odo, Jafi A Lipson, Ninah Achacoso, Joseph H Rothstein, Martin J Yaffe, Rhea Y Liang, Luana Acton, Valerie McGuire, Alice S Whitmore, Daniel L Rubin, Weiva Sieh, Laurel A Habel
BACKGROUND: High mammographic density is strongly associated with increased breast cancer risk. Some, but not all, risk factors for breast cancer are also associated with higher mammographic density. METHODS: The study cohort (N=24,840) was drawn from the Research Program in Genes, Environment and Health of Kaiser Permanente Northern California and included non-Hispanic white females aged 40-74 years with a full-field digital mammogram (FFDM). Percent density (PD) and dense area (DA) were measured by a radiological technologist using Cumulus...
July 11, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28694347/menstrual-hygiene-management-among-bangladeshi-adolescent-schoolgirls-and-risk-factors-affecting-school-absence-results-from-a-cross-sectional-survey
#8
Mahbub-Ul Alam, Stephen P Luby, Amal K Halder, Khairul Islam, Aftab Opel, Abul K Shoab, Probir K Ghosh, Mahbubur Rahman, Therese Mahon, Leanne Unicomb
BACKGROUND: Many adolescent girls in low-income and middle-income countries lack appropriate facilities and support in school to manage menstruation. Little research has been conducted on how menstruation affects school absence. This study examines the association of menstrual hygiene management knowledge, facilities and practice with absence from school during menstruation among Bangladeshi schoolgirls. METHODS: We conducted a nationally representative, cross-sectional study in Bangladeshi schools from March to June 2013 among girls 11 to 17 years old who reached menarche...
July 9, 2017: BMJ Open
https://www.readbyqxmd.com/read/28685514/association-between-body-weight-changes-and-menstrual-irregularity-the-korea-national-health-and-nutrition-examination-survey-2010-to-2012
#9
Kyung Min Ko, Kyungdo Han, Youn Jee Chung, Kun Ho Yoon, Yong Gyu Park, Seung Hwan Lee
BACKGROUND: Menstrual irregularity is an indicator of endocrine disorders and reproductive health status. It is associated with various diseases and medical conditions, including obesity and underweight. We aimed to assess the association between body weight changes and menstrual irregularity in Korean women. METHODS: A total of 4,621 women 19 to 54 years of age who participated in the 2010 to 2012 Korea National Health and Nutrition Examination Survey were included in this study...
June 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28683515/profile-of-reproductive-issues-associated-with-different-sickle-cell-disease-genotypes
#10
Flávia Anchielle Carvalho, Ariani Impieri Souza, Ana Laura Carneiro Gomes Ferreira, Simone da Silva Neto, Ana Carolina Pessoa de Lima Oliveira, Maria Luiza Rodrigues Pinheiro Gomes, Manuela Freire Hazin Costa
Purpose To describe the reproductive variables associated with different sickle cell disease (SCD) genotypes and the influence of contraceptive methods on acute painful episodes among the women with the homozygous hemoglobin S (HbSS) genotype. Methods A cross-sectional study was conducted between September of 2015 and April of 2016 on 158 women afflicted with SCD admitted to a hematology center in the Northeast of Brazil. The reproduction-associated variables of different SCD genotypes were assessed using the analysis of variance (ANOVA) test to compare means, and the Kruskal-Wallis test to compare medians...
July 6, 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28678822/father-absence-and-gendered-traits-in-sons-and-daughters
#11
Lynda G Boothroyd, Catharine P Cross
Research has previously found a number of apparently contradictory patterns in the relationship between 'father absence' (having a non-resident father during childhood) and the expression of gender roles, as well as other sexually dimorphic traits such as aggression. In the current study we measured a battery of sexually differentiated traits in relation to family background. 133 men and 558 women from the United States and Australia completed the Bem Sex Role Inventory, the Barrett Impulsivity Scale, the Fear Survey Schedule and the Buss & Perry Aggression Questionnaire...
2017: PloS One
https://www.readbyqxmd.com/read/28676131/association-of-age-at-menopause-with-post-menopausal-symptoms-menarche-age-and-other-reproductive-factors-among-rural-females-in-shimla-himachal-pradesh
#12
Krishan Sharma, Mayuk Bansal
This study analysed the association between menopause, menarche and number of live births using cross-sectional primary data for 75 post-menopausal rural women from Shimla in the Indian state of Himachal Pradesh. The mean/median ages at menarche of the 75 women were 14.23/14 years, and those at menopause 45.35/45 years. There were no significant differences in these values between women in the age groups 40-55 and 56-65 years. Age at menopause was found to be significantly associated with age at menarche and maternal age at birth of the first and last child, but not with menopausal symptom severity score...
July 5, 2017: Journal of Biosocial Science
https://www.readbyqxmd.com/read/28672280/molecular-screening-of-mkrn3-dlk1-and-kcnk9-genes-in-girls-with-idiopathic-central-precocious-puberty
#13
Anna Grandone, Carlo Capristo, Grazia Cirillo, Marcella Sasso, Giuseppina Rosaria Umano, Michela Mariani, Emanuele Miraglia Del Giudice, Laura Perrone
BACKGROUND: Mutations in the imprinted gene MKRN3 have been described as a common genetic cause of idiopathic central precocious puberty (CPP), in particular in familial cases. However, the exact prevalence of mutations is unknown. Single nucleotide polymorphisms in 2 other imprinted genes, DLK1 and KCNK9, have been associated with age at menarche. We investigated the prevalence of mutations in MKRN3, DLK1, and KCNK9 genes in a cohort of girls with idiopathic CPP. METHODS: MKRN3, DLK1, and KCNK9 coding regions were sequenced in 60 girls with idiopathic CPP (familial in 23 cases)...
July 3, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28670784/gene-environment-interactions-involving-functional-variants-results-from-the-breast-cancer-association-consortium
#14
Myrto Barrdahl, Anja Rudolph, John L Hopper, Melissa C Southey, Annegien Broeks, Peter A Fasching, Matthias W Beckmann, Manuela Gago-Dominguez, J Esteban Castelao, Pascal Guénel, Thérèse Truong, Stig E Bojesen, Susan M Gapstur, Mia M Gaudet, Hermann Brenner, Volker Arndt, Hiltrud Brauch, Ute Hamann, Arto Mannermaa, Diether Lambrechts, Lynn Jongen, Dieter Flesch-Janys, Kathrin Thoene, Fergus J Couch, Graham G Giles, Jacques Simard, Mark S Goldberg, Jonine Figueroa, Kyriaki Michailidou, Manjeet K Bolla, Joe Dennis, Qin Wang, Ursula Eilber, Sabine Behrens, Kamila Czene, Per Hall, Angela Cox, Simon Cross, Anthony Swerdlow, Minouk J Schoemaker, Alison M Dunning, Rudolf Kaaks, Paul D P Pharoah, Marjanka Schmidt, Montserrat Garcia-Closas, Douglas F Easton, Roger L Milne, Jenny Chang-Claude
Investigating the most likely causal variants identified by fine-mapping analyses may improve the power to detect gene-environment interactions. We assessed the interplay between 70 SNPs identified by genetic fine-scale mapping of susceptibility loci and 11 epidemiological breast cancer risk factors in relation to breast cancer. Analyses were conducted on up to 58,573 subjects (26,968 cases, 31,605 controls) from the Breast Cancer Association Consortium (BCAC), in one of the largest studies of its kind. Analyses were carried out separately for estrogen receptor positive (ER+) and estrogen receptor negative (ER-) disease...
July 3, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28669518/impact-of-interaction-between-ppar-alpha-and-ppar-gamma-on-breast-cancer-risk-in-the-chinese-han-population
#15
Xiong Lianggeng, Liang Baiwu, Bai Maoshu, Liu Jiming, Li Youshan
BACKGROUND: Several studies have been conducted to investigate the association of the peroxisome proliferator-activated receptor (PPAR) alpha (PPAR A) and PPAR gamma (PPAR G) polymorphism and breast cancer (BC) risk, but the results were inconsistent, and, until now, no study focused on the impact of gene-gene interactions between PPAR A and PPAR G on BC risk; thus, the aim of this study was to investigate the impact of interaction between PPAR A and PPAR G on BC risk in the Chinese Han population...
October 19, 2016: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28666132/neuropsychological-function-in-relation-to-dysmenorrhea-in-adolescents
#16
Afsane Bahrami, Hamidreza Sadeghnia, Amir Avan, Seyed Jamal Mirmousavi, Alireza Moslem, Saeed Eslami, Masoud Heshmati, Hamidreza Bahrami-Taghanaki, Gordon A Ferns, Majid Ghayour-Mobarhan
OBJECTIVE: Hormonal variations during the menstrual cycle may affect emotional regulation. We aimed to investigate the association between dysmenorrhea (the severe abdominal pain and cramps associated with menstruation) and cognitive abilities, emotional function and sleep patterns in adolescent girls. Moreover, we evaluated the frequency of premenstrual syndrome (PMS) in our population and then divided them into 4 groups: subjects with only PMS; subjects with only dysmenorrhea; individuals with both PMS and dysmenorrhea and normal subjects...
June 21, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28661938/age-at-pubertal-onset-in-girls-and-tobacco-smoke-exposure-during-pre-and-post-natal-susceptibility-windows
#17
Gayle C Windham, Raymond Lum, Robert Voss, Mary Wolff, Susan M Pinney, Susan L Teteilbaum, Connie S Sosnoff, Dina Dobraca, Frank Biro, Robert A Hiatt, Louise C Greenspan, Maida Galvez, Lawrence H Kushi
BACKGROUND: Tobacco smoke contains known hormonally active chemicals and reproductive toxicants. Several studies have examined prenatal maternal smoking and offspring age at menarche, but few examined earlier pubertal markers, nor accounted for exposure during childhood. Our objective was to examine pre- and post-natal smoke exposure in relation to timing of early pubertal events. METHODS: An ethnically diverse cohort of 1239 girls was enrolled at age 6-8 years for a longitudinal study of puberty at three U...
June 28, 2017: Epidemiology
https://www.readbyqxmd.com/read/28661550/menstrual-hygiene-management-in-resource-poor-countries
#18
Anne Sebert Kuhlmann, Kaysha Henry, L Lewis Wall
Importance: Adequate management of menstrual hygiene is taken for granted in affluent countries; however, inadequate menstrual hygiene is a major problem for girls and women in resource-poor countries, which adversely affects the health and development of adolescent girls. Objective: The aim of this article is to review the current evidence concerning menstrual hygiene management in these settings. Evidence Acquisition: A PubMed search using MeSH terms was conducted in English, supplemented by hand searching for additional references...
June 2017: Obstetrical & Gynecological Survey
https://www.readbyqxmd.com/read/28660685/studying-the-relationship-between-a-woman-s-reproductive-lifespan-and-age-at-menarche-using-a-bayesian-multivariate-structured-additive-distributional-regression-model
#19
Elisa Duarte, Bruno de Sousa, Carmen Cadarso-Suárez, Nadja Klein, Thomas Kneib, Vítor Rodrigues
Studies addressing breast cancer risk factors have been looking at trends relative to age at menarche and menopause. These studies point to a downward trend of age at menarche and an upward trend for age at menopause, meaning an increase of a woman's reproductive lifespan cycle. In addition to studying the effect of the year of birth on the expectation of age at menarche and a woman's reproductive lifespan, it is important to understand how a woman's cohort affects the correlation between these two variables...
June 29, 2017: Biometrical Journal. Biometrische Zeitschrift
https://www.readbyqxmd.com/read/28658773/haemostatic-disorder-in-women-with-unexplained-menorrhagia-a-tertiary-care-centre-experience-from-northern-india
#20
Rashmi Kushwaha, Ashutosh Kumar, Kusum Lata Mishra, Pushp Lata Sankhwar, Renu Singh
INTRODUCTION: Menorrhagia is a common gynaecological problem and its cause remains unexplained in a significant proportion of females. AIM: The present study was done to diagnose a wide range of haemostatic disorders which can give rise to menorrhagia in women of adolescent, postadolescent and perimenopausal age group. MATERIALS AND METHODS: A total of 1100 women presenting to gynaecological emergency with complaints of menorrhagia underwent comprehensive evaluation...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
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