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https://www.readbyqxmd.com/read/28099079/lymphangioleiomyomatosis-a-monogenic-model-of-malignancy
#1
Vera P Krymskaya, Francis X McCormack
Lymphangioleiomyomatosis (LAM) is a rare, low-grade, metastasizing neoplasm that arises from an unknown source, spreads via the lymphatics, and targets the lungs. All pulmonary structures become infiltrated with benign-appearing spindle and epithelioid cells (LAM cells) that express smooth-muscle and melanocyte-lineage markers, harbor mTOR-activating mutations in tuberous sclerosis complex (TSC) genes, and recruit abundant stromal cells. Elaboration of lymphangiogenic growth factors and matrix remodeling enzymes by LAM cells enables their access to lymphatic channels and likely drives the cystic lung remodeling that often culminates in respiratory failure...
January 14, 2017: Annual Review of Medicine
https://www.readbyqxmd.com/read/28097202/distinct-effects-of-obesity-and-puberty-on-risk-and-age-at-onset-of-pediatric-ms
#2
Tanuja Chitnis, Jennifer Graves, Bianca Weinstock-Guttman, Anita Belman, Cody Olsen, Madhusmita Misra, Gregory Aaen, Leslie Benson, Meghan Candee, Mark Gorman, Benjamin Greenberg, Lauren Krupp, Timothy Lotze, Soe Mar, Jayne Ness, John Rose, Jennifer Rubin, Teri Schreiner, Jan Tillema, Amy Waldman, Moses Rodriguez, Charlie Casper, Emmanuelle Waubant
OBJECTIVE: The aim of this study was to examine the relative contributions of body mass index (BMI) and pubertal measures for risk and age of onset of pediatric MS. METHODS: Case-control study of 254 (63% female) MS cases (onset<18 years of age) and 420 (49% female) controls conducted at 14 U.S. Pediatric MS Centers. Sex- and age-stratified BMI percentiles were calculated using CDC growth charts from height and weight measured at enrollment for controls, and within 1 year of onset for MS cases...
December 2016: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/28093318/massive-vulvar-linear-verrucous-epidermal-nevus-presenting-at-menarche
#3
Jaclyn Morrison, Adrienne Bonham
BACKGROUND: Epidermal nevi are benign hamartomatous growths of the skin that present at birth and develop in early childhood often linearly along the "lines of Blaschko". Verrucous linear epidermal nevi are the most common epidermal nevi and often are located on the trunk or extremities. There is minimal evidence regarding vulvar involvement and subsequent management of the associated cosmetic deformity in this anatomic location. CASE: An 11 year-old menarchal female who underwent full-thickness dermal excision of a 9...
January 13, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28089920/g-protein-coupled-estrogen-receptor-mediated-non-genomic-facilitatory-effect-of-estrogen-on-cooling-induced-reduction-of-skin-blood-flow-in-mice
#4
Izumi Serizawa, Nozomi Iwasaki, Hirotake Ishida, Shin-Ya Saito, Tomohisa Ishikawa
An enhanced vasoconstrictor activity of cutaneous arteries participates in the reduction of skin blood flow induced by cooling stimulation. Raynaud's phenomenon, which is characterized by intense cooling-induced constriction of cutaneous arteries, is more common in women during the period from menarche to menopause. We thus investigated the effect of 17β-estradiol (E2) on cooling-induced reduction of plantar skin blood flow (PSBF) in mouse in vivo. Ovariectomized female ddY mice, anaesthetized with pentobarbital, were treated with tetrodotoxin for eliminating the sympathetic nerve tone and artificially ventilated...
January 12, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28089583/association-of-prenatal-and-childhood-pbde-exposure-with-timing-of-puberty-in-boys-and-girls
#5
Kim G Harley, Stephen A Rauch, Jonathan Chevrier, Katherine Kogut, Kimberly L Parra, Celina Trujillo, Robert H Lustig, Louise C Greenspan, Andreas Sjödin, Asa Bradman, Brenda Eskenazi
BACKGROUND: Polybrominated diphenyl ether (PBDE) flame retardants are endocrine-disrupting chemicals that exhibit estrogenic and androgenic properties and may affect pubertal timing. METHODS: Study subjects were participants between 1999 and 2013 in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS), a longitudinal cohort study of predominantly Mexican origin families in Northern California. We measured serum concentrations of four PBDEs (BDE-47, -99, -100, -153) in blood collected from mothers during pregnancy (N=263) and their children at age 9years (N=522)...
January 12, 2017: Environment International
https://www.readbyqxmd.com/read/28086982/reproductive-factors-and-the-risk-of-triple-negative-breast-cancer-in-white-women-and-african-american-women-a-pooled-analysis
#6
Huiyan Ma, Giske Ursin, Xinxin Xu, Eunjung Lee, Kayo Togawa, Lei Duan, Yani Lu, Kathleen E Malone, Polly A Marchbanks, Jill A McDonald, Michael S Simon, Suzanne G Folger, Jane Sullivan-Halley, Dennis M Deapen, Michael F Press, Leslie Bernstein
BACKGROUND: Early age at menarche, nulliparity, late age at first completed pregnancy, and never having breastfed, are established breast cancer risk factors. However, among breast cancer subtypes, it remains unclear whether all of these are risk factors for triple-negative breast cancer (TNBC). METHODS: We evaluated the associations of these reproductive factors with TNBC, in 2658 patients with breast cancer (including 554 with TNBC) and 2448 controls aged 20-64 years, who participated in one of the three population-based case-control studies: the Women's Contraceptive and Reproductive Experiences Study, the Women's Breast Carcinoma in situ Study, or the Women's Learning the Influence of Family and Environment Study...
January 13, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28057133/-association-between-age-at-menarche-and-height-and-leg-length-in-adult-women-findings-from-survey-in-10-areas-in-china
#7
L L Lin, B Zheng, J Lyu, Y Guo, Z Bian, C Q Yu, L Yang, H Y Zhou, Y L Tan, P Pei, J S Chen, Z M Chen, L M Li
Objective: To describe the regional differences and secular trend in age at menarche, height and leg length in adult women aged 30-79 years in 10 areas included in China Kadoorie Biobank study (CKB), and evaluate the association between age at menarche and height and leg length in adult women in China. Methods: A total of 285 187 women, who had data on age at menarche and who had their menarche at the age between 9-18 years, were included in the analysis. Multiple linear regression models were used to assess the association between age at menarche and height and leg length...
November 10, 2016: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28050402/association-of-age-at-menarche-with-anthropometric-measures-in-punjabi-bania-girls
#8
Pratibha Goyal, Zora Singh, Gurmeet Kaur Sethi
INTRODUCTION: Menarcheal age is the age at which menstruation begins. Menarcheal age is regarded as a sensitive indicator of physical, biological and psychological environment. AIM: 1) To determine the menarcheal age and to examine the relationship between current age at menarche with anthropometric measures in Punjabi bania girls. 2) To develop maturity standards for Bania girls. MATERIALS AND METHODS: The present cross-sectional survey was carried out on 200 bania girls at the age of onset of menarche...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28041598/premature-ovarian-insufficiency-and-perinatal-parameters-a-retrospective-case-control-study
#9
S Sadrzadeh, R C Painter, Y M van Kasteren, D D M Braat, C B Lambalk
OBJECTIVE: The peak number of oocytes is reached during intrauterine development, after which numbers decline until reserves are depleted and a woman enters menopause. In premature ovarian insufficiency (POI), the process of follicle depletion occurs at a young age (generally taken as 40 years); the condition affects about 1% of women. In this study, we investigate whether women with POI had experienced a different perinatal milieu, as reflected in their birth weight or prematurity. STUDY DESIGN: In this retrospective case-control study, we evaluated whether women diagnosed with POI had a different birth weight or prematurity rate (<37 weeks) compared with women aged over 40 at natural menopause (the controls)...
February 2017: Maturitas
https://www.readbyqxmd.com/read/28041589/ovarian-aging-in-women-with-diabetes-an-overview
#10
REVIEW
Melissa F Wellons, Juliana J Matthews, Catherine Kim
Type 2 diabetes is a global epidemic, and the prevalence and incidence of type 1 diabetes are increasing. The negative effects of diabetes on kidneys, nerves, and vessels are well established. The effect of diabetes on reproductive function is less well understood, but important to characterize, given the increasing numbers of young women with diabetes. In this review, we summarize the available literature on how women with diabetes experience ovarian aging, from menarche to menopause. We report that women with type 1 diabetes appear more likely to have ovarian dysfunction, manifested by delayed menses, menstrual irregularities, and possibly earlier menopause...
February 2017: Maturitas
https://www.readbyqxmd.com/read/28029675/an-overview-of-menopausal-symptoms-in-a-district-hospital-of-nepal
#11
S Gupta, K Acharya, P Srivastav, P K Gurung, N Gupta
INTRODUCTION: Menopause is a universal reproductive phenomenon which confirms the end of fertility of the women. The objectives of this study were to establish the age of natural menopause and to identify the prevalence of menopausal symptoms among the rural women attending district hospital of Nepal. METHODS: This present study is a hospital based, observational cross-sectional study conducted in Outpatient department of Lamjung District Hospital, Lamjung, Nepal...
October 2016: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/28027719/childhood-body-mass-index-at-5-5-years-mediates-the-effect-of-prenatal-maternal-stress-on-daughters-age-at-menarche-project-ice-storm
#12
A Duchesne, A Liu, S L Jones, D P Laplante, S King
Early pubertal timing is known to put women at greater risk for adverse physiological and psychological health outcomes. Of the factors that influence girls' pubertal timing, stress experienced during childhood has been found to advance age at menarche (AAM). However, it is not known if stress experienced by mothers during or in the months before conception can be similarly associated with earlier pubertal timing. Prenatal maternal stress (PNMS) is associated with metabolic changes, such as increased childhood adiposity and risk of obesity, that have been associated with earlier menarchal age...
December 28, 2016: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28017951/-the-effects-of-exercising-in-childhood-on-bone-health
#13
Kazuhiro Imai, Jun Iwamoto, Suguru Torii, Atsushi Masujima
In contemporary Japan, there is a polarizing trend in children who exercise more than 1,800 minutes a week and those who exercise less than 60 minutes a week. Quite a lot of girls in particular hate exercise,and therefore they don't get enough of it. Osteoporosis is a preventable disease from childhood. It is crucial for girls to exercise and to provide appropriate stimulation to bones before menarche, which increases bone mineral content. Exercise and sports in childhood are characterized as the ways to the lifelong prevention strategies against osteoporosis and fractures...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28013319/determinants-of-bmi-category-changes-during-middle-childhood-and-adolescence-in-girls
#14
Katarzyna Kliś, Anna Majcher, Monika Paluchowska, Iwona Wronka
The aim of the study was to analyse the changes in BMI category between 7 and 16-18 years of age on the basis of continuous studies and evaluate which factors are related to the increase and decrease in BMI category. Data were collected from 1008 secondary school students aged 16-18 y. Body height and weight were measured and BMI was calculated. Information on height and body mass in earlier periods of life was retrieved from medical records. Age at menarche and socio-economic status was established on the basis of a questionnaire...
2016: Folia Medica Cracoviensia
https://www.readbyqxmd.com/read/28012351/the-association-between-mental-health-problems-and-menstrual-cycle-irregularity-among-adolescent-korean-girls
#15
Mi Yu, Kyungdo Han, Ga Eun Nam
BACKGROUND: Menstrual cycle irregularity is common among adolescents and can induce mental health problems such as stress, depression, and suicidal ideation. We examined the association between mental health problems and menstrual cycle irregularity among adolescent Korean girls. METHODS: This population-based cross-sectional study was on 808 female adolescents (12-18 years of age) participating in the 2010-2012 Korean National Health and Nutrition Examination Survey...
November 30, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28011924/childhood-secondhand-smoke-exposure-and-pregnancy-loss-in-never-smokers-the-guangzhou-biobank-cohort-study
#16
Shanshan Yang, Lin Xu, Yao He, Chaoqiang Jiang, Yali Jin, Kar Keung Cheng, Weisen Zhang, Tai Hing Lam
OBJECTIVE: Studies of secondhand smoke (SHS) exposure especially childhood SHS exposure and pregnancy loss are limited. We used baseline data of the Guangzhou Biobank Cohort Study (GBCS) to examine the association of childhood SHS exposure with a history of pregnancy loss. METHODS: Never smoking women aged 50 years or above in GBCS from 2003 to 2008 were included. Propensity score matching (PSM) was used to control for confounding. Negative binomial regression and logistic regression were used to examine the association of childhood SHS, assessed by number of smokers in childhood household and frequency of exposure, with past pregnancy loss...
December 23, 2016: Tobacco Control
https://www.readbyqxmd.com/read/28009526/pubertal-progression-and-reproductive-hormones-in-healthy-girls-with-transient-thelarche
#17
Marie Lindhardt Johansen, Casper P Hagen, Mikkel G Mieritz, Ole D Wolthers, Carsten Heuck, Jørgen Holm Petersen, Anders Juul
CONTEXT: Detailed evaluation of pubertal progression in girls from longitudinal studies is sparse and the phenomenon of transient thelarche (TT), defined as the appearance, regression and subsequent reappearance of breast buds, in healthy girls remains undescribed. OBJECTIVE: To describe TT in terms of pubertal progression, growth, genotypes and reproductive hormones and to apply new puberty nomograms for breast stages, pubic hair and menarche. DESIGN: A prospective, longitudinal population-based study...
December 23, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28003316/projecting-individualized-absolute-invasive-breast-cancer-risk-in-us-hispanic-women
#18
Matthew P Banegas, Esther M John, Martha L Slattery, Scarlett Lin Gomez, Mandi Yu, Andrea Z LaCroix, David Pee, Rowan T Chlebowski, Lisa M Hines, Cynthia A Thompson, Mitchell H Gail
BACKGROUND: There is no model to estimate absolute invasive breast cancer risk for Hispanic women. METHODS: The San Francisco Bay Area Breast Cancer Study (SFBCS) provided data on Hispanic breast cancer case patients (533 US-born, 553 foreign-born) and control participants (464 US-born, 947 foreign-born). These data yielded estimates of relative risk (RR) and attributable risk (AR) separately for US-born and foreign-born women. Nativity-specific absolute risks were estimated by combining RR and AR information with nativity-specific invasive breast cancer incidence and competing mortality rates from the California Cancer Registry and Surveillance, Epidemiology, and End Results program to develop the Hispanic risk model (HRM)...
February 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28000465/difference-in-fatty-acids-composition-of-breast-adipose-tissue-in-women-with-breast-cancer-and-benign-breast-disease
#19
Lisiane Lopes da Conceição, Mariana De Moura Dias, Milene Cristine Pessoa, Geórgia Das Graças Pena, Maria Carolina Santos Mendes, Cristiane Vilas Boas Neves, Helen Hermana Miranda Hermsdorff, Renata Nascimento Freitas, Maria do Carmo Gouveia Peluzio
INTRODUCTION: Breast cancer is the second most common cancer in the world, and the most frequent cancer among women. Moreover, there are factors that influence the risk for breast cancer including the age, genetic and endocrine factors, and lifestyle. OBJECTIVES: To evaluate the consumption of fatty acids; compare the fatty acids composition in the breast adipose tissue of women with breast cancer and benign breast disease as well as potential risk factors; and describe the genotypic frequency of the Pro12Ala PPARγ polymorphism...
November 29, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/27996108/effect-of-reproductive-history-and-exogenous-hormone-use-on-cognitive-function-in-mid-and-late-life
#20
Roksana Karim, Ha Dang, Victor W Henderson, Howard N Hodis, Jan St John, Roberta D Brinton, Wendy J Mack
OBJECTIVES: To investigate the association between reproductive history indicators of hormonal exposure, including reproductive period, pregnancy, and use of hormonal contraceptives, and mid- and late-life cognition in postmenopausal women. DESIGN: Analysis of baseline data from two randomized clinical trials: the Women's Isoflavone Soy Health and the Early vs Late Intervention Trial of Estradiol. SETTING: University academic research center...
December 2016: Journal of the American Geriatrics Society
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