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Ada 2014

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https://www.readbyqxmd.com/read/27899602/the-human-phenotype-ontology-in-2017
#1
Sebastian Köhler, Nicole A Vasilevsky, Mark Engelstad, Erin Foster, Julie McMurry, Ségolène Aymé, Gareth Baynam, Susan M Bello, Cornelius F Boerkoel, Kym M Boycott, Michael Brudno, Orion J Buske, Patrick F Chinnery, Valentina Cipriani, Laureen E Connell, Hugh J S Dawkins, Laura E DeMare, Andrew D Devereau, Bert B A de Vries, Helen V Firth, Kathleen Freson, Daniel Greene, Ada Hamosh, Ingo Helbig, Courtney Hum, Johanna A Jähn, Roger James, Roland Krause, Stanley J F Laulederkind, Hanns Lochmüller, Gholson J Lyon, Soichi Ogishima, Annie Olry, Willem H Ouwehand, Nikolas Pontikos, Ana Rath, Franz Schaefer, Richard H Scott, Michael Segal, Panagiotis I Sergouniotis, Richard Sever, Cynthia L Smith, Volker Straub, Rachel Thompson, Catherine Turner, Ernest Turro, Marijcke W M Veltman, Tom Vulliamy, Jing Yu, Julie von Ziegenweidt, Andreas Zankl, Stephan Züchner, Tomasz Zemojtel, Julius O B Jacobsen, Tudor Groza, Damian Smedley, Christopher J Mungall, Melissa Haendel, Peter N Robinson
Deep phenotyping has been defined as the precise and comprehensive analysis of phenotypic abnormalities in which the individual components of the phenotype are observed and described. The three components of the Human Phenotype Ontology (HPO; www.human-phenotype-ontology.org) project are the phenotype vocabulary, disease-phenotype annotations and the algorithms that operate on these. These components are being used for computational deep phenotyping and precision medicine as well as integration of clinical data into translational research...
November 28, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27882833/evaluation-of-real-world-experience-with-tofacitinib-compared-with-adalimumab-etanercept-and-abatacept-in-ra-patients-with-1-previous-biologic-dmard-data-from-a-u-s-administrative-claims-database
#2
James Harnett, Robert Gerber, David Gruben, Andrew S Koenig, Connie Chen
BACKGROUND: Real-world data comparing tofacitinib with biologic disease-modifying antirheumatic drugs (bDMARDs) are limited. OBJECTIVE: To compare characteristics, treatment patterns, and costs of patients with rheumatoid arthritis (RA) receiving tofacitinib versus the most common bDMARDs (adalimumab [ADA], etanercept [ETN], and abatacept [ABA]) following a single bDMARD in a U.S. administrative claims database. METHODS: This study was a retrospective cohort analysis of patients aged ≥ 18 years with an RA diagnosis (ICD-9-CM codes 714...
December 2016: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/27879076/drug-survival-rates-and-reasons-for-drug-discontinuation-in-psoriasis
#3
Tobias Arnold, Marthe-Lisa Schaarschmidt, Raphael Herr, Joachim E Fischer, Sergij Goerdt, Wiebke K Peitsch
BACKGROUND AND OBJECTIVES: Moderate-to-severe psoriasis frequently requires long-term systemic therapy. Reflecting efficacy, safety, and treatment satisfaction, drug survival is an indicator of therapeutic success. The objective of the present study was to assess drug survival rates and reasons for discontinuation of fumaric acid esters (FAE), methotrexate (MTX), acitretin (ACI), cyclosporine A (CyA), adalimumab (ADA), etanercept (ETA), infliximab (INF), and ustekinumab (UST) in patients with moderate-to-severe psoriasis...
November 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27879071/-drug-survival-raten-und-gr%C3%A3-nde-f%C3%A3-r-den-abbruch-von-systemtherapien-bei-psoriasis
#4
Tobias Arnold, Marthe-Lisa Schaarschmidt, Raphael Herr, Joachim E Fischer, Sergij Goerdt, Wiebke K Peitsch
HINTERGRUND UND ZIELE: Mittelschwere bis schwere Psoriasis erfordert häufig eine langfristige systemische Behandlung. Die Therapietreue bezüglich eines Medika-ments (Überlebensrate, "Drug Survival") reflektiert dessen Wirksamkeit, Sicherheit sowie die Zufriedenheit mit der Behandlung und ist ein Indikator für den Therapieerfolg. Das Ziel der vorliegenden Studie was die Ermittlung der "Drug-Survival"-Raten sowie der Gründe für den Abbruch einer Behandlung mit Fumarsäureestern (fumaric acid esters, FAE), Methotrexat (MTX), Acitretin (ACI), Cyclosporin A (CyA), Adalimumab (ADA), Etanercept (ETA), Infliximab (INF) und Ustekinumab (UST) bei Patienten mit mittelschwerer bis schwerer Psoriasis...
November 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27863809/efficacy-and-safety-of-tau-aggregation-inhibitor-therapy-in-patients-with-mild-or-moderate-alzheimer-s-disease-a-randomised-controlled-double-blind-parallel-arm-phase-3-trial
#5
Serge Gauthier, Howard H Feldman, Lon S Schneider, Gordon K Wilcock, Giovanni B Frisoni, Jiri H Hardlund, Hans J Moebius, Peter Bentham, Karin A Kook, Damon J Wischik, Bjoern O Schelter, Charles S Davis, Roger T Staff, Luc Bracoud, Kohkan Shamsi, John M D Storey, Charles R Harrington, Claude M Wischik
BACKGROUND: Leuco-methylthioninium bis(hydromethanesulfonate; LMTM), a stable reduced form of the methylthioninium moiety, acts as a selective inhibitor of tau protein aggregation both in vitro and in transgenic mouse models. Methylthioninium chloride has previously shown potential efficacy as monotherapy in patients with Alzheimer's disease. We aimed to determine whether LMTM was safe and effective in modifying disease progression in patients with mild to moderate Alzheimer's disease...
November 15, 2016: Lancet
https://www.readbyqxmd.com/read/27861691/-perceptions-and-attitudes-of-public-health-service-dentists-in-the-face-of-family-violence-in-24-municipalities-in-the-state-of-s%C3%A3-o-paulo-brazil-2013-2014
#6
Cléa Adas Saliba Garbin, Tânia Adas Saliba Rovida, Adriana Alves Costa, Artênio José Isper Garbin
OBJECTIVE: to describe the perceptions and attitudes of dentists working in Primary Healthcare Units in the face of family violence in 24 municipalities in the interior of São Paulo state, Brazil. METHOD: this is a descriptive study conducted between July 2013 and July 2014; the study population was comprised of 294 professionals; data were collected through a questionnaire containing objective and subjective questions. RESULTS: 111 dentists took part (37...
January 2016: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/27859570/diabetes-incidence-and-prevalence-in-hong-kong-china-during-2006-2014
#7
J Quan, T K Li, H Pang, C H Choi, S C Siu, S Y Tang, N M Wat, J Woo, J M Johnston, G M Leung
AIMS: To estimate recent secular changes in the incidence and prevalence of diabetes and pre-diabetes among Hong Kong Chinese adults, and thus show possible future trends for developing mainland China. METHODS: Based on a complete census of the public sector health records of 6.4 million people from 2006 to 2014, diabetes cases were ascertained using different methods including the World Health Organization (WHO) 2011 guidelines (HbA1c , fasting plasma glucose and glucose tolerance test), American Diabetes Association (ADA) 2015 guidelines (plus random plasma glucose), and additionally recorded diagnosis codes and medication dispensation...
November 12, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27845027/clinical-effectiveness-and-cost-effectiveness-of-use-of-therapeutic-monitoring-of-tumour-necrosis-factor-alpha-tnf-%C3%AE-inhibitors-lisa-tracker%C3%A2-enzyme-linked-immunosorbent-assay-elisa-kits-tnf-%C3%AE-blocker-elisa-kits-and-promonitor%C3%A2-elisa-kits-versus-standard-care
#8
Karoline Freeman, Martin Connock, Peter Auguste, Sian Taylor-Phillips, Hema Mistry, Deepson Shyangdan, Rachel Court, Ramesh Arasaradnam, Paul Sutcliffe, Aileen Clarke
BACKGROUND AND OBJECTIVES: Systematic reviews and economic modelling of clinical effectiveness and cost-effectiveness of therapeutic monitoring of tumour necrosis factor alpha (TNF-α) inhibitors [using LISA-TRACKER(®) enzyme-linked immunosorbent assay (ELISA) kits (Theradiag, Marne La Vallee, France, or Alpha Laboratories, Heriot, UK), TNF-α-Blocker ELISA kits (Immundiagnostik AG, Bensheim, Germany) and Promonitor(®) ELISA kits (Proteomika, Progenika Biopharma, Bizkaia, Spain)] versus standard care for Crohn's disease (CD)...
November 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27757251/surveillance-and-response-of-hepatitis-b-virus-in-hong-kong-special-administrative-region-1988-2014
#9
Ada Wai-Chi Lin, Ka-Hing Wong
No abstract text is available yet for this article.
January 2016: Western Pacific Surveillance and Response Journal: WPSAR
https://www.readbyqxmd.com/read/27753882/ish-ada-03-adequately-controlled-systolic-blood-pressure-is-significantly-associated-with-better-survival-rate-irrespective-of-number-of-antihypertensive-agents-in-prevalent-dialysis-patients
#10
Jong Hyun Jhee, Tae-Hyun Yoo, Su-Young Jung, Youn Kyung Kee, Jung Tak Park, Seung Hyeok Han, Shin-Wook Kang
OBJECTIVE: The object of this study is to investigate optimal BP target and adequate management of BP in prevalent dialysis patients group. DESIGN AND METHOD: The data were retrieved from End-stage Renal Disease-Clinical Research Center (ESRD-CRC) which dialysis patients were prospectively enrolled from 2009 to 2014. Total 2,299 prevalent dialysis patients were analyzed. Eligible patients were assigned to four groups according to distribution of systolic BP (SBP, group as SBP <120, 120-140, 140-160, and >160 mmHg, respectively)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753881/ish-ada-02-comparison-of-pulse-wave-velocity-and-pulse-pressure-amplification-in-the-association-with-target-organ-damages-in-the-community-based-elderly-the-northern-shanghai-study
#11
Bin Bai, Jin Xiong, Yuyan Lv, Shikai Yu, Jiadela Teliewubai, Chen Chi, Yiwu Zhou, Kai Wang, Le Wang, Yi Zhang, Yawei Xu
OBJECTIVE: To investigate the discrepancy between PWV and PPA in association with hypertensive TODs in the elderly population. DESIGN AND METHOD: From June 2014 to August 2015, a total of 1599 community-based elderly subjects (age > 65 years old) located in the northern Shanghai were recruited. The carotid-femoral pulse wave velocity (cfPWV), peripheral blood pressure (BP), central BP and other TODs indicators including the ratio of the early ventricular filling velocity (E) to the peak velocity of tissue Doppler velocity of septal mitral annulus (E/Ea), left ventricular mass index (LVMI), carotid intima-medium thickness (IMT), estimated glomerular filtration rate (eGFR), urinary albumin-creatinine rate (ACR) were assessed on each participant...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27725748/capturing-coupled-riparian-and-coastal-disturbance-from-industrial-mining-using-cloud-resilient-satellite-time-series-analysis
#12
Michael Alonzo, Jamon Van Den Hoek, Nabil Ahmed
The socio-ecological impacts of large scale resource extraction are frequently underreported in underdeveloped regions. The open-pit Grasberg mine in Papua, Indonesia, is one of the world's largest copper and gold extraction operations. Grasberg mine tailings are discharged into the lowland Ajkwa River deposition area (ADA) leading to forest inundation and degradation of water bodies critical to indigenous peoples. The extent of the changes and temporal linkages with mining activities are difficult to establish given restricted access to the region and persistent cloud cover...
October 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27651132/adalimumab-versus-infliximab-in-treating-post-operative-recurrence-of-crohn-s-disease-a-national-cohort-study
#13
Carmen-Monica Preda, Larisa Elena Fulger, Lucian Negreanu, Mircea Manuc, Irina Sandra, Mircea-Mihai Diculescu
AIM: Perform a comparison between adalimumab (ADA) and infliximab (IFX) in treating post-operative recurrence of Crohn's disease (a comparative analysis of efficacy and safety). METHODS: From the 267 patients treated with Adalimumab or Infliximab between January 2005 and June 2014 in Romania, 44 received anti- TNF (tumor necrosis factor) therapy for prevention of post-operative recurrence. A comparison between patients treated with IFX and ADA was made with the Chi- square and t- student test, with the aid of the statistical program Mini Tab 17...
October 2016: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/27643175/ish-ada-03-adequately-controlled-systolic-blood-pressure-is-significantly-associated-with-better-survival-rate-irrespective-of-number-of-antihypertensive-agents-in-prevalent-dialysis-patients
#14
Jong Hyun Jhee, Tae-Hyun Yoo, Su-Young Jung, Youn Kyung Kee, Jung Tak Park, Seung Hyeok Han, Shin-Wook Kang
OBJECTIVE: The object of this study is to investigate optimal BP target and adequate management of BP in prevalent dialysis patients group. DESIGN AND METHOD: The data were retrieved from End-stage Renal Disease-Clinical Research Center (ESRD-CRC) which dialysis patients were prospectively enrolled from 2009 to 2014. Total 2,299 prevalent dialysis patients were analyzed. Eligible patients were assigned to four groups according to distribution of systolic BP (SBP, group as SBP <120, 120-140, 140-160, and >160 mmHg, respectively)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27643174/ish-ada-02-comparison-of-pulse-wave-velocity-and-pulse-pressure-amplification-in-the-association-with-target-organ-damages-in-the-community-based-elderly-the-northern-shanghai-study
#15
Bin Bai, Jin Xiong, Yuyan Lv, Shikai Yu, Jiadela Teliewubai, Chen Chi, Yiwu Zhou, Kai Wang, Le Wang, Yi Zhang, Yawei Xu
OBJECTIVE: To investigate the discrepancy between PWV and PPA in association with hypertensive TODs in the elderly population. DESIGN AND METHOD: From June 2014 to August 2015, a total of 1599 community-based elderly subjects (age > 65 years old) located in the northern Shanghai were recruited. The carotid-femoral pulse wave velocity (cfPWV), peripheral blood pressure (BP), central BP and other TODs indicators including the ratio of the early ventricular filling velocity (E) to the peak velocity of tissue Doppler velocity of septal mitral annulus (E/Ea), left ventricular mass index (LVMI), carotid intima-medium thickness (IMT), estimated glomerular filtration rate (eGFR), urinary albumin-creatinine rate (ACR) were assessed on each participant...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27586104/predicting-crash-relevant-violations-at-stop-sign-controlled-intersections-for-the-development-of-an-intersection-driver-assistance-system
#16
John M Scanlon, Rini Sherony, Hampton C Gabler
OBJECTIVE: Intersection crashes resulted in over 5,000 fatalities in the United States in 2014. Intersection Advanced Driver Assistance Systems (I-ADAS) are active safety systems that seek to help drivers safely traverse intersections. I-ADAS uses onboard sensors to detect oncoming vehicles and, in the event of an imminent crash, can either alert the driver or take autonomous evasive action. The objective of this study was to develop and evaluate a predictive model for detecting whether a stop sign violation was imminent...
September 2016: Traffic Injury Prevention
https://www.readbyqxmd.com/read/27568359/use-of-standardised-patients-to-assess-antibiotic-dispensing-for-tuberculosis-by-pharmacies-in-urban-india-a-cross-sectional-study
#17
Srinath Satyanarayana, Ada Kwan, Benjamin Daniels, Ramnath Subbaraman, Andrew McDowell, Sofi Bergkvist, Ranendra K Das, Veena Das, Jishnu Das, Madhukar Pai
BACKGROUND: India's total antibiotic use is the highest of any country. Patients often receive prescription-only drugs directly from pharmacies. Here we aimed to assess the medical advice and drug dispensing practices of pharmacies for standardised patients with presumed and confirmed tuberculosis in India. METHODS: In this cross-sectional study in the three Indian cities Delhi, Mumbai, and Patna, we developed two standardised patient cases: first, a patient presenting with 2-3 weeks of pulmonary tuberculosis symptoms (Case 1); and second, a patient with microbiologically confirmed pulmonary tuberculosis (Case 2)...
November 2016: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/27440958/a-case-of-figurate-urticaria-by-etanercept
#18
Maurizio Sessa, Maria Giuseppa Sullo, Annamaria Mascolo, Daniela Cimmaruta, Francesca Romano, Rosa Valentina Puca, Annalisa Capuano, Francesco Rossi, Ada Lo Schiavo
Etanercept is a competitive inhibitor of tumor necrosis factor-alpha (TNF-α) a polypeptide hormone, involved in the development of the immune system, in host defense and immune surveillance. Even if the etanercept mechanism of action is not completely understood, it is supposed that it negatively modulates biological responses mediated by molecules (cytokines, adhesion molecules, or proteinases) induced or regulated by TNF. For this reason, it is widely used in the treatment of immunologicals diseases, such as rheumatoid and psoriatic arthritis, polyarticular juvenile idiopathic active, ankylosing spondylitis, and plaque psoriasis...
April 2016: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/27220829/infliximab-adalimumab-and-golimumab-for-treating-moderately-to-severely-active-ulcerative-colitis-after-the-failure-of-conventional-therapy-including-a-review-of-ta140-and-ta262-clinical-effectiveness-systematic-review-and-economic-model
#19
Rachel Archer, Paul Tappenden, Shijie Ren, Marrissa Martyn-St James, Rebecca Harvey, Hasan Basarir, John Stevens, Christopher Carroll, Anna Cantrell, Alan Lobo, Sami Hoque
BACKGROUND: Ulcerative colitis (UC) is the most common form of inflammatory bowel disease in the UK. UC can have a considerable impact on patients' quality of life. The burden for the NHS is substantial. OBJECTIVES: To evaluate the clinical effectiveness and safety of interventions, to evaluate the incremental cost-effectiveness of all interventions and comparators (including medical and surgical options), to estimate the expected net budget impact of each intervention, and to identify key research priorities...
May 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27191537/safety-of-antitumour-necrosis-factor-treatments-in-chronic-rheumatic-diseases-therapy-discontinuations-related-to-side-effects
#20
H Varela, E Villamañán, C Plasencia, J A Romero, M Ruano, A Balsa, A Herrero
WHAT IS KNOWN AND OBJECTIVE: The appearance of antitumor necrosis factor drugs (ATDs) has been a major advance in the management of these patients. However, due to the immunosuppressive effect of these therapies, side effects that require treatment discontinuations can appear. The purpose of this study was to evaluate the frequency of ATD discontinuation due to adverse drug effects (ADEs) and the influence of different factors such as diagnosis, ATD prescribed and concomitant disease-modifying antirheumatic drugs (DMARDs)...
June 2016: Journal of Clinical Pharmacy and Therapeutics
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