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https://www.readbyqxmd.com/read/28985037/postoperative-sinonasal-morbidity-in-sellar-reconstruction-mucosal-autograft-versus-acellular-dermal-allograft
#1
Christopher R Roxbury, J Trent Magruder, Murugappan Ramanathan, Michael Lim, Gary L Gallia, Masaru Ishii, Douglas D Reh
BACKGROUND: Sellar pathology is increasingly addressed using the expanded endonasal approach (EEA). Although avascular graft reconstruction is an acceptable means to prevent cerebrospinal fluid leak, there are few data regarding sinonasal morbidity in these patients. In this study we compare rates of persistent postoperative crusting (PPC) and rhinosinusitis in patients undergoing sellar reconstruction with mucosal autografting and acellular dermal allografting (ADA). METHODS: Patients undergoing the EEA between 2008 and 2014 were categorized into 2 subgroups: mucosal reconstruction and ADA reconstruction...
October 6, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28979981/genome-wide-association-studies-of-a-broad-spectrum-of-antisocial-behavior
#2
Jorim J Tielbeek, Ada Johansson, Tinca J C Polderman, Marja-Riitta Rautiainen, Philip Jansen, Michelle Taylor, Xiaoran Tong, Qing Lu, Alexandra S Burt, Henning Tiemeier, Essi Viding, Robert Plomin, Nicholas G Martin, Andrew C Heath, Pamela A F Madden, Grant Montgomery, Kevin M Beaver, Irwin Waldman, Joel Gelernter, Henry R Kranzler, Lindsay A Farrer, John R B Perry, Marcus Munafò, Devon LoParo, Tiina Paunio, Jari Tiihonen, Sabine E Mous, Irene Pappa, Christiaan de Leeuw, Kyoko Watanabe, Anke R Hammerschlag, Jessica E Salvatore, Fazil Aliev, Tim B Bigdeli, Danielle Dick, Stephen V Faraone, Arne Popma, Sarah E Medland, Danielle Posthuma
Importance: Antisocial behavior (ASB) places a large burden on perpetrators, survivors, and society. Twin studies indicate that half of the variation in this trait is genetic. Specific causal genetic variants have, however, not been identified. Objectives: To estimate the single-nucleotide polymorphism-based heritability of ASB; to identify novel genetic risk variants, genes, or biological pathways; to test for pleiotropic associations with other psychiatric traits; and to reevaluate the candidate gene era data through the Broad Antisocial Behavior Consortium...
October 4, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28928177/adherence-and-dosing-interval-of-subcutaneous-antitumour-necrosis-factor-biologics-among-patients-with-inflammatory-arthritis-analysis-from-a-canadian-administrative-database
#3
Peter Bhoi, Louis Bessette, Mary J Bell, Cathy Tkaczyk, Francois Nantel, Karina Maslova
OBJECTIVES: Subcutaneous tumour necrosis factor alpha TNFαinhibitors (SC-TNFis) such as golimumab (GLM), adalimumab (ADA), etanercept (ETA) and certolizumab pegol (CZP) have been used for many years for the treatment of inflammatory arthritis. Non-adherence to therapy is an important modifiable factor that may compromise patient outcomes. The aim of this analysis was to compare adherence and dosing interval of SC-TNFis in the treatment of people with inflammatory arthritis. DESIGN: We used the IMS Brogan database combining both Canadian private and public drug plan databases of Ontario and Quebec...
September 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28846528/effects-of-preoperative-tricuspid-valve-diameters-on-early-postoperative-surgical-outcomes-in-patients-undergoing-tricuspid-valve-surgery
#4
Fatih Ada, Kemalettin Ucanok, Ahmet Ruchan Akar, Mustafa Bahadir Inan, Serkan Durdu, Mustafa Sirlak, Levent Yazicioglu, Adnan Uysalel, Sadik Eryilmaz
BACKGROUND: Many of the previous studies on tricuspid valve surgery were on the materials that were used and the advantages and disadvantages of them. In this study, effects of preoperative tricuspid valve diameter on early postoperative outcomes were investigated. Methods: A total of 43 patients who underwent tricuspid valve repair surgery with the ring between the years 2012-2014 were included in this study. Tricuspid valve diameters and other cardiac functions of patients undergoing tricuspid intervention were evaluated with transthoracic echocardiography...
August 24, 2017: Heart Surgery Forum
https://www.readbyqxmd.com/read/28765451/ten-year-student-trends-in-u-s-dental-schools-2004-05-to-2014-15
#5
Allan J Formicola
This article provides an overview of the status of students applying to and enrolling in dental schools in the United States over a ten-year period from 2004-05 to 2014-15. The data are mainly drawn from published reports of the American Dental Association (ADA) and American Dental Education Association (ADEA). This overview includes trends on tuition levels, diversity in enrollment, and debt levels of students upon graduation as well as students' satisfaction with their education. This article was written as part of the project "Advancing Dental Education in the 21(st) Century...
August 2017: Journal of Dental Education
https://www.readbyqxmd.com/read/28763462/sativex-in-resistant-multiple-sclerosis-spasticity-discontinuation-study-in-a-large-population-of-italian-patients-sa-fe-study
#6
Silvia Messina, Claudio Solaro, Isabella Righini, Roberto Bergamaschi, Simona Bonavita, Roberto Bruno Bossio, Vincenzo Brescia Morra, Gianfranco Costantino, Paola Cavalla, Diego Centonze, Giancarlo Comi, Salvatore Cottone, Maura Chiara Danni, Ada Francia, Alberto Gajofatto, Claudio Gasperini, Mauro Zaffaroni, Loredana Petrucci, Elisabetta Signoriello, Giorgia Teresa Maniscalco, Gabriella Spinicci, Manuela Matta, Massimiliano Mirabella, Graziella Pedà, Letizia Castelli, Marco Rovaris, Edoardo Sessa, Daniele Spitaleri, Damiano Paolicelli, Alfredo Granata, Mario Zappia, Francesco Patti
BACKGROUND: The approval of Sativex for the management of multiple sclerosis (MS) spasticity opened a new opportunity to many patients. In Italy, the healthcare payer can be fully reimbursed by the involved pharma company with the cost of treatment for patients not responding after a 4 week (28 days) trial period (Payment by Results, PbR), and 50% reimbursed with the cost of 6 weeks (42 days) treatment for other patients discontinuing (Cost Sharing, CS). The aim of our study was to describe the Sativex discontinuation profile from a large population of spasticity treated Italian MS patients...
2017: PloS One
https://www.readbyqxmd.com/read/28737988/patterns-of-care-for-biologic-dosing-outliers-and-nonoutliers-in-biologic-naive-patients-with-rheumatoid-arthritis
#7
Thomas Delate, Roxanne Meyer, Daniel Jenkins
BACKGROUND: Although most biologic medications for patients with rheumatoid arthritis (RA) have recommended fixed dosing, actual biologic dosing may vary among real-world patients, since some patients can receive higher (high-dose outliers) or lower (low-dose outliers) doses than what is recommended in medication package inserts. OBJECTIVE: To describe the patterns of care for biologic-dosing outliers and nonoutliers in biologic-naive patients with RA. METHODS: This was a retrospective, longitudinal cohort study of patients with RA who were not pregnant and were aged ≥ 18 and < 90 years from an integrated health care delivery system...
August 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28728264/-exploratory-research-on-diagnostic-essentials-of-pediatric-tuberculous-pleurisy
#8
H Xu, J R Liu, S Y Zhao
Objective: To summarize the clinical diagnostic essentials of pediatric tuberculous pleurisy so as to reduce the misdiagnosis rate. Method: A retrospective study was conducted on 113 cases of tuberculous pleurisy who were seen from August 2006 to September 2014 in the second Department of Respiratory Medicine, Beijing Children's Hospital Affiliated to Capital Medical University. Meanwhile, another 113 cases of children over 5 years of age with mycoplasma pneumoniae pneumonia complicated with pleural effusion were randomly selected as control group...
July 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28701420/comparative-evaluation-of-subtyping-tools-for-surveillance-of-newly-emerging-hiv-1-strains
#9
Lavinia Fabeni, Giulia Berno, Joseph Fokam, Ada Bertoli, Claudia Alteri, Caterina Gori, Federica Forbici, Desiré Takou, Alessandra Vergori, Mauro Zaccarelli, Gaetano Maffongelli, Vanni Borghi, Alessandra Latini, Alfredo Pennica, Claudio Maria Mastroianni, Francesco Montella, Cristina Mussini, Massimo Andreoni, Andrea Antinori, Carlo Federico Perno, Maria Mercedes Santoro
HIV-1 non-B subtypes/circulating recombinant forms (CRFs) are increasing worldwide. Since subtype identification can be clinically relevant, we assessed the added value in HIV-1 subtyping using updated molecular phylogeny (Mphy) and the performance of routinely used automated tools. Updated Mphy (2015 updated reference sequences), used as a gold standard, was performed to subtype 13,116 HIV-1 protease/reverse transcriptase sequences and then compared with previous Mphy (reference sequences until 2014) and with COMET, REGA, SCUEAL, and Stanford subtyping tools...
September 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28586255/disparities-in-assisted-reproductive-technology-utilization-by-race-and-ethnicity-united-states-2014-a-commentary
#10
Ada C Dieke, Yujia Zhang, Dmitry M Kissin, Wanda D Barfield, Sheree L Boulet
Disparities in infertility and access to infertility treatments, such as assisted reproductive technology (ART), by race/ethnicity, have been reported. However, identifying disparities in ART usage may have been hampered by missing race/ethnicity information in ART surveillance. We review infertility prevalence and treatment disparities, use recent data to examine ART use in the United States by race/ethnicity and residency in states with mandated insurance coverage for in vitro fertilization (IVF), and discuss approaches for reducing disparities...
June 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28577692/ulcerative-colitis-treatment-patterns-and-cost-of-care
#11
COMPARATIVE STUDY
Kyle D Null, Yihua Xu, Margaret K Pasquale, Chinyu Su, Amy Marren, James Harnett, Jack Mardekian, Alireza Manuchehri, Paul Healey
OBJECTIVES: To examine treatment patterns, dosing, health care resource utilization, and cost of tumor necrosis factor inhibitors (TNFi), adalimumab (ADA) and infliximab (IFX), among patients enrolled in US Humana insurance plans who have been diagnosed with ulcerative colitis (UC). METHODS: This retrospective cohort study identified the first pharmacy or medical claim for ADA or IFX (from January 1, 2007, to December 31, 2014) in patients with continuous enrollment for 6 months or more preindex and 12 months or more postindex, with one or more UC diagnosis claim 6 months pre- or postindex...
June 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28507772/clinically-significant-depressive-symptoms-and-sexual-behaviour-among-men-who-have-sex-with-men
#12
Ada R Miltz, Alison J Rodger, Janey Sewell, Andrew Speakman, Andrew N Phillips, Lorraine Sherr, Richard J Gilson, David Asboe, Nneka C Nwokolo, Amanda Clarke, Mark M Gompels, Sris Allan, Simon Collins, Fiona C Lampe
BACKGROUND: The relationship between depression and sexual behaviour among men who have sex with men (MSM) is poorly understood. AIMS: To investigate prevalence and correlates of depressive symptoms (Patient Health Questionnaire-9 score ≥10) and the relationship between depressive symptoms and sexual behaviour among MSM reporting recent sex. METHOD: The Attitudes to and Understanding of Risk of Acquisition of HIV (AURAH) is a cross-sectional study of UK genitourinary medicine clinic attendees without diagnosed HIV (2013-2014)...
May 2017: BJPsych Open
https://www.readbyqxmd.com/read/28488283/switching-of-biologics-in-psoriasis-reasons-and-results
#13
Hiromi Honda, Yoshinori Umezawa, Sota Kikuchi, Koichi Yanaba, Osamu Fukuchi, Toshihiro Ito, Yoshimasa Nobeyama, Akihiko Asahina, Hidemi Nakagawa
Efficacy and safety profiles of biologics have been established for moderate to severe psoriasis. However, inefficacy or adverse events sometimes require changing the treatment to other biologics. Here, we examine the effectiveness of this strategy. We retrospectively investigated cases requiring switching biologics. We enrolled 275 psoriatic patients treated with biologics between January 2010 and December 2014 in our hospital. Of these, 51 required a switch to another biologic. First-line therapies were infliximab (IFX, n = 26), adalimumab (ADA, n = 18) and ustekinumab (UST, n = 7), and second-line therapies were IFX (n = 5), ADA (n = 21) and UST (n = 25)...
September 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28483337/individualised-prediction-model-of-seizure-recurrence-and-long-term-outcomes-after-withdrawal-of-antiepileptic-drugs-in-seizure-free-patients-a-systematic-review-and-individual-participant-data-meta-analysis
#14
REVIEW
Herm J Lamberink, Willem M Otte, Ada T Geerts, Milen Pavlovic, Julio Ramos-Lizana, Anthony G Marson, Jan Overweg, Letícia Sauma, Luigi M Specchio, Michael Tennison, Tania M O Cardoso, Shlomo Shinnar, Dieter Schmidt, Karin Geleijns, Kees P J Braun
BACKGROUND: People with epilepsy who became seizure-free while taking antiepileptic drugs might consider discontinuing their medication, with the possibility of increased quality of life because of the elimination of adverse events. The risk with this action, however, is seizure recurrence. The objectives of our study were to identify predictors of seizure recurrence and long-term seizure outcomes and to produce nomograms for estimation of individualised outcomes. METHODS: We did a systematic review and meta-analysis, and identified eligible articles and candidate predictors, using PubMed and Embase databases with a last update on Nov 6, 2014...
July 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28479884/prevalence-and-socioeconomic-correlates-of-autism-among-children-attending-primary-and-secondary-schools-in-south-east-nigeria
#15
Josephat M Chinawa, Pius C Manyike, Elias C Aniwada, Awoere T Chinawa, Herbert A Obu, Odutola I Odetunde, Ada Rc Nwokocha, Roland R Ibekwe
OBJECTIVES: The objectives of the study were to determine the prevalence and socio-economic determinants of autism among children attending primary and secondary schools in South East, Nigeria. METHODS: This was a cross-sectional study that assessed the prevalence and socio-economic pattern of childhood autism among children attending primary and secondary schools in Enugu and Ebonyi states, South East Nigeria. The questionnaire was adapted from American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR, 2000)...
December 2016: African Health Sciences
https://www.readbyqxmd.com/read/28406120/knowledge-of-hepatitis-b-virus-infection-among-traders
#16
U C Okonkwo, O E Ngim, H Osim, M A Inyama, M Kooffreh-Ada E Esu, R Ndoma-Egba, E Ezedinachi
INTRODUCTION: Hepatitis B virus (HBV) is a public health problem in Nigeria, with 13% of its general population having evidence of a previous or current infection. Lack of awareness of HBV, its risk factors, and its consequences are recognized as major deterrents to adopting positive preventive behavior including immunization among HBV high-risk groups. OBJECTIVE: The objective of this study is to evaluate the knowledge, attitude, and practice (KAP) of HBV infection among traders...
April 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28347721/extra-analytical-quality-indicators-and-laboratory-performances
#17
REVIEW
Laura Sciacovelli, Ada Aita, Mario Plebani
In the last few years much progress has been made in raising the awareness of laboratory medicine professionals about the effectiveness of quality indicators (QIs) in monitoring, and improving upon, performances in the extra-analytical phases of the Total Testing Process (TTP). An effective system for management of QIs includes the implementation of an internal assessment system and participation in inter-laboratory comparison. A well-designed internal assessment system allows the identification of critical activities and their systematic monitoring...
July 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28241357/effect-of-collaborative-care-vs-usual-care-on-depressive-symptoms-in-older-adults-with-subthreshold-depression-the-casper-randomized-clinical-trial
#18
RANDOMIZED CONTROLLED TRIAL
Simon Gilbody, Helen Lewis, Joy Adamson, Katie Atherton, Della Bailey, Jacqueline Birtwistle, Katharine Bosanquet, Emily Clare, Jaime Delgadillo, David Ekers, Deborah Foster, Rhian Gabe, Samantha Gascoyne, Lesley Haley, Jahnese Hamilton, Rebecca Hargate, Catherine Hewitt, John Holmes, Ada Keding, Amanda Lilley-Kelly, Shaista Meer, Natasha Mitchell, Karen Overend, Madeline Pasterfield, Jodi Pervin, David A Richards, Karen Spilsbury, Gemma Traviss-Turner, Dominic Trépel, Rebecca Woodhouse, Friederike Ziegler, Dean McMillan
Importance: There is little evidence to guide management of depressive symptoms in older people. Objective: To evaluate whether a collaborative care intervention can reduce depressive symptoms and prevent more severe depression in older people. Design, Setting, and Participants: Randomized clinical trial conducted from May 24, 2011, to November 14, 2014, in 32 primary care centers in the United Kingdom among 705 participants aged 65 years or older with Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) subthreshold depression; participants were followed up for 12 months...
February 21, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28221250/factors-associated-with-discontinuation-of-anti-tnf-inhibitors-among-persons-with-ibd-a-population-based-analysis
#19
Laura E Targownik, Aruni Tennakoon, Stella Leung, Lisa M Lix, Zoann Nugent, Harminder Singh, Charles N Bernstein
INTRODUCTION: Antitumor necrosis factor (anti-TNF) medications are known to be highly efficacious in persons with moderate-to-severe inflammatory bowel disease (IBD). There is a paucity of data from population-based sources to elucidate persistence with these medications in the general population of IBD. Discontinuation of anti-TNF therapy is a marker of lack of effectiveness, intolerance, and patient/physician practice preferences. METHODS: We identified all persons with IBD in Manitoba who were dispensed infliximab (IFX) and adalimumab (ADA) between 2001 and 2014...
March 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28160418/comparison-of-the-risk-of-infections-in-different-anti-tnf-agents-a-meta-analysis
#20
Hongxing Liao, Zhixiong Zhong, Zhanliang Liu, Xuenong Zou
BACKGROUND: Anti-tumor necrosis factor α (anti-TNF-α) treatments are widely used in patients with rheumatoid arthritis (RA); however, the increased risk of infections is one of the most important side effects of anti-TNF-α agents. This study evaluated the differences between monoclonal antibodies and the soluble receptor for infections in patients with RA by direct comparison of observation studies. METHODS: A systemic literature search was conducted in March 2014 and an up-to-date search was conducted in August 2014...
February 3, 2017: International Journal of Rheumatic Diseases
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