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https://www.readbyqxmd.com/read/29217376/safety-tolerability-and-immunogenicity-of-two-zika-virus-dna-vaccine-candidates-in-healthy-adults-randomised-open-label-phase-1-clinical-trials
#1
Martin R Gaudinski, Katherine V Houser, Kaitlyn M Morabito, Zonghui Hu, Galina Yamshchikov, Ro Shauna Rothwell, Nina Berkowitz, Floreliz Mendoza, Jamie G Saunders, Laura Novik, Cynthia S Hendel, LaSonji A Holman, Ingelise J Gordon, Josephine H Cox, Srilatha Edupuganti, Monica A McArthur, Nadine G Rouphael, Kirsten E Lyke, Ginny E Cummings, Sandra Sitar, Robert T Bailer, Bryant M Foreman, Katherine Burgomaster, Rebecca S Pelc, David N Gordon, Christina R DeMaso, Kimberly A Dowd, Carolyn Laurencot, Richard M Schwartz, John R Mascola, Barney S Graham, Theodore C Pierson, Julie E Ledgerwood, Grace L Chen
BACKGROUND: The Zika virus epidemic and associated congenital infections have prompted rapid vaccine development. We assessed two new DNA vaccines expressing premembrane and envelope Zika virus structural proteins. METHODS: We did two phase 1, randomised, open-label trials involving healthy adult volunteers. The VRC 319 trial, done in three centres, assessed plasmid VRC5288 (Zika virus and Japanese encephalitis virus chimera), and the VRC 320, done in one centre, assessed plasmid VRC5283 (wild-type Zika virus)...
December 4, 2017: Lancet
https://www.readbyqxmd.com/read/29214319/electrocardiographic-findings-in-national-basketball-association-athletes
#2
Marc P Waase, R Kannan Mutharasan, William Whang, Marco R DiTullio, John P DiFiori, Lisa Callahan, Jimmie Mancell, Dermot Phelan, Allan Schwartz, Shunichi Homma, David J Engel
Importance: While it is known that long-term intensive athletic training is associated with cardiac structural changes that can be reflected on surface electrocardiograms (ECGs), there is a paucity of sport-specific ECG data. This study seeks to clarify the applicability of existing athlete ECG interpretation criteria to elite basketball players, an athlete group shown to develop significant athletic cardiac remodeling. Objective: To generate normative ECG data for National Basketball Association (NBA) athletes and to assess the accuracy of athlete ECG interpretation criteria in this population...
December 6, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/29209658/surgical-pathology-resident-rotation-restructuring-at-a-tertiary-care-academic-center
#3
Chelsea R Mehr, Amrom E Obstfeld, Amanda C Barrett, Kathleen T Montone, Lauren E Schwartz
Changes in the field of pathology and resident education necessitate ongoing evaluation of residency training. Evolutionary change is particularly important for surgical pathology rotations, which form the core of anatomic pathology training programs. In the past, we organized this rotation based on subjective insight. When faced with the recent need to restructure the rotation, we strove for a more evidence-based process. Our approach involved 2 primary sources of data. We quantified the number of cases and blocks submitted per case type to estimate workload and surveyed residents about the time required to gross specimens in all organ systems...
January 2017: Academic Pathology
https://www.readbyqxmd.com/read/29205070/trends-in-types-of-calls-managed-by-u-s-poison-centers-2000-2015
#4
Bruce D Anderson, Hyunuk Seung, Wendy Klein-Schwartz
AIM: The number of cases reported to poison centers has decreased since 2008 but there is evidence that the complexity of calls is increasing. OBJECTIVES: The objectives are to evaluate national poison center data for trends in reason and how these changes effect management site, medical outcomes, and poison center workload. METHODS: Data regarding reason, age, management site, and medical outcome were extracted from annual reports of the National Poison Data System from 2000 to 2015...
December 5, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/29189523/bilateral-sacral-ala-fractures-are-strongly-associated-with-lumbopelvic-instability
#5
Julius A Bishop, Sean Dangelmajer, Ian Corcoran-Schwartz, Michael J Gardner, Milton L Chip Routt, Tiffany N Castillo
OBJECTIVES: To quantify the incidence of lumbopelvic instability in the setting of unilateral and bilateral sacral fractures and assess whether the presence of bilateral sacral fractures on axial imaging is a useful screening test for lumbopelvic instability. DESIGN: Retrospective case series. SETTING: Level I trauma center at an academic medical center. PATIENTS/PARTICIPANTS: A hospital database was used to identify patients diagnosed with a sacral fracture by The International Classification of Diseases, Ninth Revision (ICD-9) code from 2000 to 2014...
December 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29181796/risk-factors-for-an-elevated-ventricular-end-diastolic-pressure-prior-to-the-fontan-operation
#6
Matthew C Schwartz, Michael A Brock, David Nykanen, William DeCampli
Systemic ventricular end-diastolic pressure (SVEDP) is an important determinant of pulmonary artery pressure in those with a Fontan circulation. Predictors of an elevated SVEDP have been incompletely identified in this population. All who underwent the Fontan operation at our center between 1/2009 and 12/2013 were retrospectively identified. SVEDP at the pre-Fontan catheterization and other patient variables were extracted. We identified 61 patients. Pre-Fontan SVEDP was positively associated with systemic ventricular systolic pressure (β = 0...
November 27, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/29171802/is-the-chiasm-pituitary-corridor-size-important-for-achieving-gross-total-resection-during-endonasal-endoscopic-resection-of-craniopharyngiomas
#7
Sacit Bulent Omay, João Paulo Almeida, Yu-Ning Chen, Sathwik R Shetty, Buqing Liang, Shilei Ni, Vijay K Anand, Theodore H Schwartz
OBJECTIVE Craniopharyngiomas arise from the pituitary stalk, and in adults they are generally located posterior to the chiasm extending up into the third ventricle. The extended endonasal approach (EEA) can provide an ideal corridor between the bottom of the optic chiasm and the top of the pituitary gland (chiasm-pituitary corridor [CPC]) for their removal. A narrow CPC in patients with a prefixed chiasm and a large tumor extending up and behind the chiasm has been considered a contraindication to EEA, with a high risk of visual deterioration and subtotal resection...
November 24, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29164609/who-benefits-from-adolescent-sleep-interventions-moderators-of-treatment-efficacy-in-a-randomized-controlled-trial-of-a-cognitive-behavioral-and-mindfulness-based-group-sleep-intervention-for-at-risk-adolescents
#8
Matthew J Blake, Laura M Blake, Orli Schwartz, Monika Raniti, Joanna M Waloszek, Greg Murray, Julian G Simmons, Elizabeth Landau, Ronald E Dahl, Dana L McMakin, Paul Dudgeon, John Trinder, Nicholas B Allen
BACKGROUND: The aim of this study was to test moderators of therapeutic improvement in an adolescent cognitive-behavioral and mindfulness-based group sleep intervention. Specifically, we examined whether the effects of the program on postintervention sleep outcomes were dependent on participant gender and/or measures of sleep duration, anxiety, depression, and self-efficacy prior to the interventions. METHOD: Secondary analysis of a randomized controlled trial conducted with 123 adolescent participants (female = 59...
November 22, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29146571/using-schwartz-center-rounds-to-promote-compassionate-care-in-a-children-s-hospital
#9
Jan Hughes, Alistair J Duff, John W L Puntis
No abstract text is available yet for this article.
November 16, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29125649/milker-s-nodule-an-occupational-infection-and-threat-to-the-immunocompromised
#10
REVIEW
Nancy S Handler, M Z Handler, Andris Rubins, Silvestr Rubins, Marcis Septe, Camila K Janniger, Robert A Schwartz
Milker's nodule virus, also called paravaccinia virus is a DNA virus of the parapoxvirus genus transmitted from infected cows to humans. It results from contact with cattle, cattle byproducts, or fomites. Classified as an occupational disorder, those at risk of exposure include farmers, butchers, and agricultural tourists. The viral infection begins 5-15 days after inoculation as an erythematous-purple, round nodule with a clear depressed center, and a surrounding erythematous ring. While familiar to those in farming communities, the presence of the nodule may be concerning to others, particularly the immunosuppressed...
November 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29125446/suprasellar-and-recurrent-pediatric-craniopharyngiomas-expanding-indications-for-the-extended-endoscopic-transsphenoidal-approach
#11
Andrew F Alalade, Elizabeth Ogando-Rivas, Jerome Boatey, Mark M Souweidane, Vijay K Anand, Jeffrey P Greenfield, Theodore H Schwartz
OBJECTIVE The expanded endonasal endoscopic transsphenoidal approach has become increasingly used for craniopharyngioma surgery in the pediatric population, but questions still persist regarding its utility in younger children, in recurrent and irradiated tumors, and in masses primarily located in the suprasellar region. The narrow corridor, incomplete pneumatization, and fear of hypothalamic injury have traditionally relegated this approach to application in older children with mostly cystic craniopharyngiomas centered in the sella...
November 10, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29120515/the-effects-of-crew-resource-management-on-teamwork-and-safety-climate-at-veterans-health-administration-facilities
#12
Miriam E Schwartz, Deborah E Welsh, Douglas E Paull, Regina S Knowles, Lori D DeLeeuw, Robin R Hemphill, Keith E Essen, Gary L Sculli
Communication failure is a significant source of adverse events in health care and a leading root cause of sentinel events reported to the Joint Commission. The Veterans Health Administration National Center for Patient Safety established Clinical Team Training (CTT) as a comprehensive program to enhance patient safety and to improve communication and teamwork among health care professionals. CTT is based on techniques used in aviation's Crew Resource Management (CRM) training. The aviation industry has reached a significant safety record in large part related to the culture change generated by CRM and sustained by its recurrent implementation...
November 9, 2017: Journal of Healthcare Risk Management: the Journal of the American Society for Healthcare Risk Management
https://www.readbyqxmd.com/read/29116980/rethinking-the-educator-portfolio-an-innovative-criteria-based-model
#13
Kanade Shinkai, Chen Amy Chen, Brian S Schwartz, Helen Loeser, Cynthia Ashe, David M Irby
PROBLEM: Academic medical centers struggle to achieve parity in advancement and promotions between educators and discovery-oriented researchers in part because of narrow definitions of scholarship, lack of clear criteria for measuring excellence, and barriers to making educational contributions available for peer review. Despite recent progress in expanding scholarship definitions and identifying excellence criteria, these advances are not integrated into educator portfolio (EP) templates or curriculum vitae platforms...
November 7, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29112200/peripheral-eosinophilia-in-patients-with-inflammatory-bowel-disease-defines-an-aggressive-disease-phenotype
#14
Benjamin Click, Alyce M Anderson, Ioannis E Koutroubakis, Claudia Ramos Rivers, Dmitriy Babichenko, Jorge D Machicado, Douglas J Hartman, Jana G Hashash, Michael A Dunn, Marc Schwartz, Jason Swoger, Arthur Barrie Iii, Sally E Wenzel, Miguel Regueiro, David G Binion
OBJECTIVES: Peripheral blood eosinophilia (PBE) in inflammatory bowel disease (IBD) is associated with ulcerative colitis (UC) and active disease. Little data exist on the long-term impact of PBE on disease course. We aimed to investigate the multi-year patterns of PBE and its impact on disease severity in a large IBD cohort. METHODS: We performed a registry analysis of a consented, prospective, natural history IBD cohort at a tertiary center from 2009 to 2014. Demographics, comorbidities, disease activity, healthcare utilization, and time to hospitalization or surgical resection of patients who displayed PBE were compared to patients without PBE...
November 7, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29106329/the-naims-cooperative-pilot-project-design-implementation-and-future-directions
#15
Jiwon Oh, Rohit Bakshi, Peter A Calabresi, Ciprian Crainiceanu, Roland G Henry, Govind Nair, Nico Papinutto, R Todd Constable, Daniel S Reich, Daniel Pelletier, William Rooney, Daniel Schwartz, Ian Tagge, Russell T Shinohara, Jack H Simon, Nancy L Sicotte
The North American Imaging in Multiple Sclerosis (NAIMS) Cooperative represents a network of 27 academic centers focused on accelerating the pace of magnetic resonance imaging (MRI) research in multiple sclerosis (MS) through idea exchange and collaboration. Recently, NAIMS completed its first project evaluating the feasibility of implementation and reproducibility of quantitative MRI measures derived from scanning a single MS patient using a high-resolution 3T protocol at seven sites. The results showed the feasibility of utilizing advanced quantitative MRI measures in multicenter studies and demonstrated the importance of careful standardization of scanning protocols, central image processing, and strategies to account for inter-site variability...
October 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29099614/blood-leukocyte-concentrations-fev1-decline-and-airflow-limitation-a-15-year-longitudinal-study-of-wtc-exposed-firefighters
#16
Rachel Zeig-Owens, Ankura Singh, Thomas K Aldrich, Charles B Hall, Theresa Schwartz, Mayris P Webber, Hillel W Cohen, Kerry J Kelly, Anna Nolan, David J Prezant, Michael D Weiden
RATIONALE: Rescue/recovery work at the World Trade Center (WTC) disaster site caused a proximate decline in lung function in Fire Department of the City of New York (FDNY) firefighters. A subset of this cohort experienced an accelerated rate of lung function decline over 15 years of post-9/11 follow-up. OBJECTIVES: To determine if post-exposure inflammatory cell concentrations are biomarkers for subsequent forced expiratory volume (FEV1) decline and incident airflow limitation...
November 3, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29090534/challenges-and-advantages-in-wide-field-optical-coherence-tomography-angiography-imaging-of-the-human-retinal-and-choroidal-vasculature-at-1-7-mhz-a-scan-rate
#17
Raju Poddar, Justin V Migacz, Daniel M Schwartz, John S Werner, Iwona Gorczynska
We present noninvasive, three-dimensional, depth-resolved imaging of human retinal and choroidal blood circulation with a swept-source optical coherence tomography (OCT) system at 1065-nm center wavelength. Motion contrast OCT imaging was performed with the phase-variance OCT angiography method. A Fourier-domain mode-locked light source was used to enable an imaging rate of 1.7 MHz. We experimentally demonstrate the challenges and advantages of wide-field OCT angiography (OCTA). In the discussion, we consider acquisition time, scanning area, scanning density, and their influence on visualization of selected features of the retinal and choroidal vascular networks...
October 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29066191/low-gait-efficiency-is-the-primary-reason-for-the-increased-metabolic-demand-during-gait-in-children-with-cerebral-palsy
#18
Andrew J Ries, Michael H Schwartz
Children diagnosed with cerebral palsy (CP) use two to three times more metabolic energy to walk than their typically developing (TD) peers. The primary cause of the metabolic increase remains unknown. In this study, we analyzed metabolic energy, center of mass (COM) work, and gait efficiency for a large group of children diagnosed with diplegic CP in order to better understand the source of the excessive metabolic demand. Our primary hypothesis is that metabolic demand is increased in CP due to low efficiency conversion of metabolic energy into useful COM work...
October 21, 2017: Human Movement Science
https://www.readbyqxmd.com/read/29061283/liver-resection-for-metastases-not-of-colorectal-neuroendocrine-sarcomatous-or-ovarian-ncnso-origin-a-multicentric-study
#19
Ismail Labgaa, Ksenija Slankamenac, Erik Schadde, Ghalib Jibara, Kutaiba Alshebeeb, Gilles Mentha, Pierre-Alain Clavien, Myron Schwartz
BACKGROUND: Liver resection is a well-established treatment for colorectal, neuroendocrine and sarcomatous metastases but remains ill-defined for metastases from other primary sites. This study aimed to analyze the outcomes of hepatic resection for metastases not of colorectal, neuroendocrine, sarcomatous, or ovarian (NCNSO) origin and to identify predictors of outcome. METHODS: Retrospective analysis of patients undergoing resection for NCNSO metastases in three western centers...
October 7, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/29052816/depressive-symptoms-predict-anti-tumor-necrosis-factor-therapy-noncompliance-in-patients-with-inflammatory-bowel-disease
#20
Alexis Calloway, Robin Dalal, Dawn B Beaulieu, Caroline Duley, Kimberly Annis, Lawrence Gaines, Chris Slaughter, David A Schwartz, Sara Horst
BACKGROUND: Noncompliance in use of anti-tumor necrosis factor (anti-TNF) therapy in patients with moderate-to-severe inflammatory bowel disease (IBD) can be a factor in medication failure. Few studies have evaluated the contribution of depressive symptoms to medication noncompliance in anti-TNF therapies. METHODS: A retrospective chart review was performed in a single-center tertiary care IBD center for patients with Crohn's disease and ulcerative colitis starting anti-TNF therapy over a 2-year period...
December 2017: Digestive Diseases and Sciences
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