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https://www.readbyqxmd.com/read/28062554/prediction-of-resistance-to-intravenous-immunoglobulin-in-children-with-kawasaki-disease
#1
Maskit Bar-Meir, Itai Kalisky, Andrei Schwartz, Eli Somekh, Diana Tasher
BACKGROUND: Approximately 10%-20% of patients with Kawasaki disease (KD) are refractory to initial intravenous immunoglobulin (IVIg) therapy, and these "nonresponders" are at higher risk of coronary artery abnormalities. Early identification of these patients, who may benefit from additional therapy, is challenging. The aim of the present study is to identify predictors for IVIg resistance. METHODS: We reviewed clinical records of 312 consecutive KD patients from 9 medical centers in Israel (development dataset) and 186 patients from additional 5 centers (validation dataset)...
January 6, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28060178/assessment-of-splints-applied-for-pediatric-fractures-in-an-emergency-department-urgent-care-environment
#2
Joshua M Abzug, Brandon S Schwartz, Aaron J Johnson
BACKGROUND: Fractures are common in the pediatric population. The initial evaluation is rarely by an orthopaedic surgeon, but commonly an emergency room or urgent care center physician/extender. This typically involves splint application by a nonorthopaedist to immobilize the extremity and provide stabilization. Iatrogenic injuries from inappropriate splint placement are a potential public health and legal concern that can lead to complications. The primary purpose of this study was to prospectively evaluate the adequacy of all splints placed on patients who presented to a pediatric orthopaedic office; secondary outcomes included assessing prevalence and types of complications that were associated with inadequate splints...
January 5, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28057662/exploring-the-adoption-of-schwartz-center-rounds-as-an-organisational-innovation-to-improve-staff-well-being-in-england-2009-2015
#3
Glenn Robert, Julia Philippou, Mary Leamy, Ellie Reynolds, Shilpa Ross, Laura Bennett, Cath Taylor, Caroline Shuldham, Jill Maben
OBJECTIVES: Schwartz Center Rounds ('Rounds') are a multidisciplinary forum in which healthcare staff within an organisation discuss the psychological, emotional and social challenges associated with their work in a confidential and safe environment. Implemented in over 375 North American organisations, since 2009, they have been increasingly adopted in England. This study aimed to establish how many and what types of organisations have adopted Rounds in England, and to explore why they did so...
January 5, 2017: BMJ Open
https://www.readbyqxmd.com/read/28050259/support-for-compassionate-care-quantitative-and-qualitative-evaluation-of-schwartz-center-rounds-in-an-acute-general-hospital
#4
Raymond J Chadwick, Steven J Muncer, Bronagh C Hannon, Joanna Goodrich, Jocelyn Cornwell
OBJECTIVE: To evaluate the impact of Schwartz Center Rounds, a multi-disciplinary forum to reflect on the emotional consequences of working in healthcare, on the staff of a large acute general hospital over a three-year period. DESIGN: Evaluation data following each Round were collected routinely from all staff attending over this period and analysed quantitatively and qualitatively. SETTING: An integrated university teaching trust with both acute hospital and community services in the North East of England...
July 2016: JRSM Open
https://www.readbyqxmd.com/read/28029576/could-enzyme-replacement-therapy-promote-immune-tolerance-in-gaucher-disease-type-1
#5
Marina Cadena Matta, Filippo Vairo, Leuridan Cavalcante Torres, Ida Schwartz
Among the lysosomal storage disorders, Gaucher disease (GD) features some of the most striking alterations in the immune system, including increased levels of cytokines and chemokines. Although studies have demonstrated the efficacy of enzyme replacement therapy (ERT) for GD, the ideal dosage remains controversial. In this study, we report differences in levels of cytokines (IL-6, TNF-a, and IFN-y) and chemokines (IL-8, IP-10, and MCP-1) in patients with GD type 1 treated with different ERT dosages and treatment durations...
October 24, 2016: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/28003273/ebi2-overexpression-in-mice-leads-to-b1-b-cell-expansion-and-chronic-lymphocytic-leukemia-cll-like-b-cell-malignancies
#6
Kristine Niss Arfelt, Line Barington, Tau Benned-Jensen, Valentina Kubale, Alexander L Kovalchuk, Viktorija Daugvilaite, Jan Pravsgaard Christensen, Allan Randrup Thomsen, Kristoffer L Egerod, Maria R Bassi, Katja Spiess, Thue W Schwartz, Hongsheng Wang, Herbert C Morse, Peter J Holst, Mette M Rosenkilde
Human and mouse chronic lymphocytic leukemia (CLL) develop from CD5+ B cells that in mice and macaques are known to define the distinct B1a B cell lineage. B1a cells are characterized by lack of germinal center development and the B1a cell population is increased in mice with reduced germinal center formation. As a major mediator of follicular B cell migration, the G protein-coupled receptor (GPCR) Epstein Barr virus-induced gene 2 (EBI2 or GPR183) directs B cell migration in the lymphoid follicles in response to its endogenous ligands, oxysterols...
December 21, 2016: Blood
https://www.readbyqxmd.com/read/28002553/efficacy-of-staged-excision-with-permanent-section-margin-control-for-cutaneous-head-and-neck-melanoma
#7
Jeffrey S Moyer, Shannon Rudy, Philip S Boonstra, Casey Kraft, Steven B Chinn, Shan R Baker, Jennifer L Schwartz, Christopher K Bichakjian, Douglas Fullen, Alison B Durham, Lori Lowe, Timothy M Johnson
Importance: Melanoma arising in chronically photodamaged skin, especially on the head and neck, is often characterized by poorly defined clinical margins and unpredictable occult extension. Staged excision techniques have been described to treat these challenging melanomas. Objective: To investigate the local recurrence rates and margin to clearance end points using staged excision with comprehensive hematoxylin-eosin-stained permanent section margin control. Design, Setting, and Participants: In this observational cohort study performed from October 8, 1997, to December 31, 2006, with a median follow-up of 9...
December 21, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27988907/appraisal-assessment-in-patient-reported-outcome-research-methods-for-uncovering-the-personal-context-and-meaning-of-quality-of-life
#8
REVIEW
Carolyn E Schwartz, Joel A Finkelstein, Bruce D Rapkin
BACKGROUND: Recent work on patient-reported outcomes (PROs) focuses on precise, brief measures, which generally convey little about what an individual's rating actually means. Individual differences in appraisal are important and relevant to PRO research. This paper highlights the advantages of integrating appraisal assessment into clinical research. METHODS: The most comprehensive method for assessing appraisal, the quality of life (QOL) Appraisal Profile, includes open-ended and multiple choice questions to assess four appraisal parameters: frame of reference, sampling of experience, standards of comparison, and combinatory algorithm...
December 17, 2016: Quality of Life Research
https://www.readbyqxmd.com/read/27984354/predictors-of-suboptimal-follow-up-in-pediatric-cancer-survivors
#9
Leana May, David D Schwartz, Ernest Frugé, Larry Laufman, Suzanne Holm, Kala Kamdar, Lynnette Harris, Julienne Brackett, Sule Unal, Gulsah Tanyildiz, Rosalind Bryant, Hilary Suzawa, Zoann Dreyer, M Fatih Okcu
Attendance to follow-up care after completion of cancer treatment is an understudied area. We examined demographic, clinical, and socioeconomic predictors of follow-up by pediatric cancer patients at a large center in 442 newly diagnosed patients using multivariable logistic regression analyses. Patients who did not return to clinic for at least 1000 days were considered lost to follow-up. Two hundred forty-two (54.8%) patients were lost. In multivariable analyses, the following variables were independent predictors of being lost to follow-up: treatment with surgery alone (odds ratio [OR]=6...
December 14, 2016: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/27924361/prevalence-of-non-cardiovascular-findings-on-ct-angiography-in-children-with-congenital-heart-disease
#10
Archana Malik, Jeffrey C Hellinger, Sabah Servaes, Mathew C Schwartz, Marc S Keller, Monica Epelman
BACKGROUND: CT angiography is gaining broader acceptance in the evaluation of children with known or suspected congenital heart disease. These studies include non-cardiovascular structures such as the mediastinum, lung parenchyma and upper abdominal organs. It is important to inspect all these structures for potential abnormalities that might be clinically important and, in some cases, may impact care plans. OBJECTIVE: To determine the prevalence of non-cardiovascular findings in CT angiography of children with congenital heart disease...
December 6, 2016: Pediatric Radiology
https://www.readbyqxmd.com/read/27920145/three-small-receptive-field-ganglion-cells-in-the-mouse-retina-are-distinctly-tuned-to-size-speed-and-object-motion
#11
Jason Jacoby, Gregory W Schwartz
: Retinal ganglion cells (RGCs) are frequently divided into functional types by their ability to extract and relay specific features from a visual scene, such as the capacity to discern local or global motion, direction of motion, stimulus orientation, contrast or uniformity, or the presence of large or small objects. Here we introduce three previously uncharacterized, non-direction selective ON-OFF RGC types that represent a distinct set of feature detectors in the mouse retina. The three high definition (HD) RGCs possess small receptive field (RF) centers and strong surround suppression...
December 5, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27917575/efficacy-and-tolerability-of-a-new-topical-nitric-zinc-preparation-for-difficult-to-treat-warts
#12
Camila K Janniger, Robert A Schwartz
Treating plantar, periungual, and external genital warts can be challenging. A prospective study from four centers in Italy evaluated 37 immunocompetent patients with single or multiple warts and treated each lesion with a nitric-zinc topical solution composed of organic and inorganic acids meant to devitalize tissue and destroy HPV DNA in infected keratinocytes. Thirty of the 37 patients had external genital warts, two had plantar warts, two had palm and finger warts, and three had subungual warts for a total of 55 lesions treated...
December 5, 2016: Dermatologic Therapy
https://www.readbyqxmd.com/read/27898605/initial-results-of-a-safety-and-feasibility-study-of-auditory-brainstem-implantation-in-congenitally-deaf-children
#13
Eric P Wilkinson, Laurie S Eisenberg, Mark D Krieger, Marc S Schwartz, Margaret Winter, Jamie L Glater, Amy S Martinez, Laurel M Fisher, Robert V Shannon
OBJECTIVE: To determine the safety and feasibility of the auditory brainstem implant (ABI) in congenitally deaf children with cochlear aplasia and/or cochlear nerve deficiency. STUDY DESIGN: Phase I feasibility clinical trial of surgery in 10 children, ages 2 to 5 years, over a 3-year period. SETTING: Tertiary children's hospital and university-based pediatric speech/language/hearing center. INTERVENTION(S): ABI implantation and postsurgical programming...
November 24, 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27893080/travel-associated-zika-virus-disease-acquired-in-the-americas-through-february-2016-a-geosentinel-analysis
#14
Davidson H Hamer, Kira A Barbre, Lin H Chen, Martin P Grobusch, Patricia Schlagenhauf, Abraham Goorhuis, Perry J J van Genderen, Israel Molina, Hilmir Asgeirsson, Phyllis E Kozarsky, Eric Caumes, Stefan H Hagmann, Frank P Mockenhaupt, Gilles Eperon, Elizabeth D Barnett, Emmanuel Bottieau, Andrea K Boggild, Philippe Gautret, Noreen A Hynes, Susan Kuhn, R Ryan Lash, Karin Leder, Michael Libman, Denis J M Malvy, Cecilia Perret, Camilla Rothe, Eli Schwartz, Annelies Wilder-Smith, Martin S Cetron, Douglas H Esposito
Background: Zika virus has spread rapidly in the Americas and has been imported into many nonendemic countries by travelers. Objective: To describe clinical manifestations and epidemiology of Zika virus disease in travelers exposed in the Americas. Design: Descriptive, using GeoSentinel records. Setting: 63 travel and tropical medicine clinics in 30 countries. Patients: Ill returned travelers with a confirmed, probable, or clinically suspected diagnosis of Zika virus disease seen between January 2013 and 29 February 2016...
November 22, 2016: Annals of Internal Medicine
https://www.readbyqxmd.com/read/27876531/patient-centered-quality-of-life-measures-after-alloplastic-temporomandibular-joint-replacement-surgery
#15
X Alakailly, D Schwartz, N Alwanni, C Demko, M A Altay, Y Kilinc, D A Baur, F Quereshy
The purpose of this study was to evaluate patient-reported outcome measures of quality of life (QoL) for patients with end-stage temporomandibular joint (TMJ) disease who have undergone TMJ prosthetic replacement. The records of 36 patients who had undergone alloplastic total joint replacement procedures were analyzed. Patients were treated using either TMJ Concepts or Biomet/Lorenz prosthetics. Patients were asked to complete a 12-item TMJ-S-QoL survey, which encompassed questions pertaining to pain, speech, chewing function, and various aspects of social life and mental health...
February 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27870568/morbidity-and-mortality-differences-between-hematopoietic-cell-transplantation-survivors-and-other-cancer-survivors
#16
Eric J Chow, Kara L Cushing-Haugen, Guang-Shing Cheng, Michael Boeckh, Nandita Khera, Stephanie J Lee, Wendy M Leisenring, Paul J Martin, Beth A Mueller, Stephen M Schwartz, K Scott Baker
Purpose To compare the risks of serious health outcomes among hematopoietic cell transplantation (HCT) survivors versus a matched population of patients with cancer who did not undergo HCT, where the primary difference may be exposure to HCT. Methods Two-year HCT survivors treated at a comprehensive cancer center from 1992 through 2009 who were Washington State residents (n = 1,792; 52% allogeneic and 90% hematologic malignancies) were frequency matched by demographic characteristics and underlying cancer diagnosis (as applicable) to non-HCT 2-year cancer survivors, using the state cancer registry (n = 5,455) and the general population (n = 16,340) using driver's license files...
November 21, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27866323/measuring-compassion-in-healthcare-a-comprehensive-and-critical-review
#17
REVIEW
Shane Sinclair, Lara B Russell, Thomas F Hack, Jane Kondejewski, Richard Sawatzky
BACKGROUND: There is international concern about the lack of compassion in healthcare systems. A valid and reliable tool for measuring compassion in healthcare systems and educational institutions is required. This comprehensive and critical narrative synthesis identified and compared existing measures of compassionate care in clinical settings. METHODS: PubMed, MEDLINE, CINAHL and PsycINFO databases and grey literature were searched to identify studies that report information on instruments that measure compassion or compassionate care in clinicians, nurses, healthcare students and patients...
November 19, 2016: Patient
https://www.readbyqxmd.com/read/27834965/clinical-outcomes-of-gamma-irradiated-sterile-cornea-in-aqueous-drainage-device-surgery-a-multicenter-retrospective-study
#18
Q Pan, H D Jampel, P Ramulu, G F Schwartz, F Cotter, D Cute, Y J Daoud, P Murakami, W J Stark
PurposeThe purpose of the study was to evaluate the safety and efficacy of gamma-irradiated sterile cornea (GISC) for covering the tube in aqueous drainage device (ADD) surgery in a retrospective, multicenter case series.Patients and methodsParticipants included 297 patients (321 procedures) who had undergone ADD surgery for the first time using GISC patch at three clinic centers in the United States between April 2009 and July 2012. The medical records of those consecutive patients were reviewed. Preoperative, intraoperative, and postoperative parameters about GISC were collected and analyzed...
November 11, 2016: Eye
https://www.readbyqxmd.com/read/27824733/outcomes-of-bone-anchored-hearing-aids-baha-for-single-sided-deafness-in-nontraditional-candidates
#19
Seth R Schwartz, Deborah Kobylk
OBJECTIVE: To assess both quality of life (QOL) and hearing outcomes in bone anchored hearing aid (BAHA) users for single sided deafness with 1) less than total hearing loss in the deaf ear, or 2) some degree of hearing loss in the better ear and compare them to traditional candidates. STUDY DESIGN: Prospective comparative cohort study. SETTING: Tertiary referral center. PATIENTS: Patients with a BAHA for single sided deafness were assigned into groups based on hearing thresholds in the deaf ear (> or <90 dBHL) and the control ear (> or <25 dBHL)...
December 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27810938/post-9-11-2001-lung-function-trajectories-by-sex-and-race-in-world-trade-center-exposed-new-york-city-emergency-medical-service-workers
#20
Madeline Vossbrinck, Rachel Zeig-Owens, Charles B Hall, Theresa Schwartz, William Moir, Mayris P Webber, Hillel W Cohen, Anna Nolan, Michael D Weiden, Vasilios Christodoulou, Kerry J Kelly, Thomas K Aldrich, David J Prezant
OBJECTIVE: To determine whether lung function trajectories after 9/11/2001 (9/11) differed by sex or race/ethnicity in World Trade Center-exposed Fire Department of the City of New York emergency medical service (EMS) workers. METHOD: Serial cross-sectional study of pulmonary function tests (PFTs) taken between 9/11 and 9/10/2015. We used data from routine PFTs (forced expiratory volume in 1 s (FEV1) and FEV1% predicted), conducted at 12-18 month intervals. FEV1 and FEV1% predicted were assessed over time, stratified by sex, and race/ethnicity...
November 3, 2016: Occupational and Environmental Medicine
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