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https://www.readbyqxmd.com/read/29429348/postoperative-antibiotics-following-cochlear-implantation-are-they-necessary
#1
Galit Almosnino, Daniel M Zeitler, Seth R Schwartz
OBJECTIVE: Evaluate whether prophylactic antibiotics administered following cochlear implant (CI) surgery impact short-term infection rates. DESIGN: Retrospective, concurrent, case-control. SETTING: Tertiary referral center. PATIENTS: All patients (range, 9 months-91 years) undergoing cochlear implantation between 2013 and 2017 (n = 188). INTERVENTION(S): Starting in 2015, one surgeon stopped prescribing postoperative antibiotics after CI surgery...
February 1, 2018: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29420640/disparities-in-availability-of-essential-medicines-to-treat-non-communicable-diseases-in-uganda-a-poisson-analysis-using-the-service-availability-and-readiness-assessment
#2
Mari Armstrong-Hough, Sandeep P Kishore, Sarah Byakika, Gerald Mutungi, Marcella Nunez-Smith, Jeremy I Schwartz
OBJECTIVE: Although the WHO-developed Service Availability and Readiness Assessment (SARA) tool is a comprehensive and widely applied survey of health facility preparedness, SARA data have not previously been used to model predictors of readiness. We sought to demonstrate that SARA data can be used to model availability of essential medicines for treating non-communicable diseases (EM-NCD). METHODS: We fit a Poisson regression model using 2013 SARA data from 196 Ugandan health facilities...
2018: PloS One
https://www.readbyqxmd.com/read/29393839/the-effect-of-time-since-loss-on-grief-resilience-and-depression-among-bereaved-emerging-adults
#3
Laura E Schwartz, Kathryn H Howell, Lacy E Jamison
Grief research has typically centered on one time point, without considering the impact of multiple losses over time. In this study, 546 bereaved emerging adults were divided into three groups: those who experienced a recent loss (0-2 years ago), a past loss (>2 years ago), or a combination of both recent and past losses. Differences between the groups on resilience, depression, and grief symptomatology were examined. Those who had experienced both losses (recent and past) and recent losses endorsed significantly more grief symptoms than those in the past loss group...
February 2, 2018: Death Studies
https://www.readbyqxmd.com/read/29389914/acute-illnesses-and-injuries-related-to-total-release-foggers-10-states-2007-2015
#4
Ruiling Liu, Walter A Alarcon, Geoffrey M Calvert, Kathleen G Aubin, John Beckman, Karen R Cummings, Lucia S Graham, Sheila A Higgins, Prakash Mulay, Ketki Patel, Joanne B Prado, Abby Schwartz, Derry Stover, Justin Waltz
Total release foggers (TRFs) (also known as "bug bombs") are pesticide products often used indoors to kill insects. After an earlier report found that TRFs pose a risk for acute illness (1), the Environmental Protection Agency required improved labels on TRFs manufactured after September 2012 (2). To examine the early impact of relabeling, the magnitude and characteristics of acute TRF-related illness were evaluated for the period 2007-2015. A total of 3,222 TRF-related illnesses were identified in 10 participating states, based on three data sources: Sentinel Event Notification System for Occupational Risk-Pesticides (SENSOR) programs, the California Department of Pesticide Regulation (CDPR) program, and poison control centers (PCCs) in Florida, Texas, and Washington...
February 2, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29364886/safety-and-pharmacokinetics-of-the-fc-modified-hiv-1-human-monoclonal-antibody-vrc01ls-a-phase-1-open-label-clinical-trial-in-healthy-adults
#5
Martin R Gaudinski, Emily E Coates, Katherine V Houser, Grace L Chen, Galina Yamshchikov, Jamie G Saunders, LaSonji A Holman, Ingelise Gordon, Sarah Plummer, Cynthia S Hendel, Michelle Conan-Cibotti, Margarita Gomez Lorenzo, Sandra Sitar, Kevin Carlton, Carolyn Laurencot, Robert T Bailer, Sandeep Narpala, Adrian B McDermott, Aryan M Namboodiri, Janardan P Pandey, Richard M Schwartz, Zonghui Hu, Richard A Koup, Edmund Capparelli, Barney S Graham, John R Mascola, Julie E Ledgerwood
BACKGROUND: VRC01 is a human broadly neutralizing monoclonal antibody (bnMAb) against the CD4-binding site of the HIV-1 envelope glycoprotein (Env) that is currently being evaluated in a Phase IIb adult HIV-1 prevention efficacy trial. VRC01LS is a modified version of VRC01, designed for extended serum half-life by increased binding affinity to the neonatal Fc receptor. METHODS AND FINDINGS: This Phase I dose-escalation study of VRC01LS in HIV-negative healthy adults was conducted by the Vaccine Research Center (VRC) at the National Institutes of Health (NIH) Clinical Center (Bethesda, MD)...
January 2018: PLoS Medicine
https://www.readbyqxmd.com/read/29360876/longitudinal-network-structure-of-depression-symptoms-and-self-efficacy-in-low-income-mothers
#6
Hudson P Santos, Jolanda J Kossakowski, Todd A Schwartz, Linda Beeber, Eiko I Fried
Maternal depression was recently conceptualized as a network of interacting symptoms. Prior studies have shown that low self-efficacy, as an index of maternal functioning, is one important source of stress that worsens depression. We have limited information, however, on the specific relationships between depression symptoms and self-efficacy. In this study, we used regularized partial correlation networks to explore the multivariate relationships between maternal depression symptoms and self-efficacy over time...
2018: PloS One
https://www.readbyqxmd.com/read/29344318/noninvasive-long-term-monitoring-of-actinic-keratosis-and-field-cancerization-following-treatment-with-ingenol-mebutate-gel-0-015
#7
Orit Markowitz, Katie Wang, Amanda Levine, Michelle Schwartz, Sumeet Minhas, Eleanor Feldman, Daniel M Siegel
OBJECTIVE: To determine whether actinic keratosis and photodamaged perilesional areas (field cancerization) treated successfully with topical ingenol mebutate gel 0.015% remained clear one year later, and to treat actinic keratosis and perilesional skin not treated one year earlier. DESIGN: Single-center, single-arm, open-label extension of an original clinical study completed one year earlier. SETTING: An outpatient clinic. PARTICIPANTS: Fifteen of the original 28 study patients enrolled in and who completed the extension phase...
October 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29336758/occult-appendiceal-neoplasms-in-acute-and-chronic-appendicitis-a-single-institution-experience-of-1793-appendectomies
#8
Jamie A Schwartz, Craig Forleiter, David Lee, Grace J Kim
The incidence of appendiceal neoplasms may have been underreported in the past. Patients undergoing incidental appendectomies or appendectomies for chronic appendicitis may be at higher risk for an incidental appendiceal neoplasm. To determine the incidence of occult appendiceal neoplasms and identify risk factors associated with this pathology, a retrospective review of a pathology specimen database was conducted from November 2007 to December 2011, in a single tertiary care hospital center. All patients with appendectomies were included for analysis (n = 1793)...
December 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/29311011/-screening-for-nephropathy-in-major-sickle-cell-syndromes-in-patients-monitored-at-the-national-reference-center-for-sickle-cell-disease-in-niamey-niger
#9
Moumouni Garba, Zeinabou Maiga Moussa Tondi, Hassan Diongoule, Samaila Aboubacar, Abdou Ide, Nadège Ruddy Biyao-Nelson, Illiassou Soumaila, Soumana Alido
BACKGROUND: Sickle cell anemia is the most common hereditary hemopathy in the world. It is a disease that attacks all the systems of the organism. The kidneys are among the most sensitive organs of this disease. The main objective of this study is to detect sickle cell nephropathy in patients followed at the National Reference Center for Sickle Cell Disease in Niamey. METHODS: It is a prospective study carried out over a period of one year (January to December 2016)...
January 5, 2018: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29298242/contemporary-management-of-high-grade-renal-trauma-results-from-the-american-association-for-the-surgery-of-trauma-aast-genitourinary-trauma-study
#10
Sorena Keihani, Yizhe Xu, Angela P Presson, James M Hotaling, Raminder Nirula, Joshua Piotrowski, Christopher M Dodgion, Cullen M Black, Kaushik Mukherjee, Bradley J Morris, Sarah Majercik, Brian P Smith, Ian Schwartz, Sean P Elliott, Erik S DeSoucy, Scott Zakaluzny, Peter B Thomsen, Bradley A Erickson, Nima Baradaran, Benjamin N Breyer, Brandi Miller, Richard A Santucci, Matthew M Carrick, Timothy Hewitt, Frank N Burks, Jurek F Kocik, Reza Askari, Jeremy B Myers
BACKGROUND: The rarity of renal trauma limits its study and the strength of evidence-based guidelines. Although management of renal injuries has shifted towards a non-operative approach, nephrectomy remains the most common intervention for high-grade renal trauma (HGRT). We aimed to describe the contemporary management of HGRT in the United States and also evaluate clinical factors associated with nephrectomy after HGRT. METHODS: From 2014 to 2017, data on HGRT (American Association for the Surgery of Trauma [AAST] grades III-V) were collected from 14 participating Level-1 trauma centers...
January 2, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29290737/abuse-and-misuse-of-selected-dietary-supplements-among-adolescents-a-look-at-poison-center-data
#11
Jessica M Biggs, Jill A Morgan, Allison B Lardieri, Omayma A Kishk, Wendy Klein-Schwartz
OBJECTIVE: The use of dietary supplements has increased and is associated with adverse effects. Indications for use include recreation, body image concerns, mood enhancement, or control of medical conditions. The risk of adverse effects may be enhanced if agents are used improperly. The objective of this study was to determine the frequency of abuse and misuse of 4 dietary substances among adolescents reported nationally to poison centers. Secondary outcomes included an assessment of medical outcomes, clinical effects, location of treatments provided, and treatments administered...
November 2017: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/29286434/mri-guided-focused-ultrasound-thalamotomy-for-patients-with-medically-refractory-essential-tremor
#12
Ying Meng, Yuexi Huang, Benjamin Solomon, Kullervo Hynynen, Nadia Scantlebury, Michael L Schwartz, Nir Lipsman
Essential tremor (ET) is the most common type of tremor in adults. While ET does not result in decreased life expectancy, the disabilities associated with ET can have a significant impact on quality of life, mood, functional activities, and socialization. Patients suffering from ET not sufficiently treated with first line medications may be eligible for alternative strategies such as deep brain stimulation, radiofrequency ablation, and MRI guided focused ultrasound (MRgFUS). High-intensity MRgFUS is an emerging modality to treat ET, its attraction for patients being that it is noninvasive and associated with short recovery time, as patients are home the day after treatment...
December 13, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29277619/epithelioid-granulomas-associate-with-increased-severity-and-progression-of-crohn-s-disease-based-on-6-year-follow-up
#13
Christopher M Johnson, Douglas J Hartman, Claudia Ramos-Rivers, Bhavana Bhagya Rao, Abhik Bhattacharya, Miguel Regueiro, Marc Schwartz, Jason Swoger, Jana Al Hashash, Arthur Barrie, Timothy P Pfanner, Michael Dunn, Ioannis E Koutroubakis, David G Binion
BACKGROUND & AIMS: Epithelioid granulomas are characteristics of a subset of patients with Crohn's disease (CD), but their significance, with regard to disease progression and severity, is unclear. We investigated the relationship between granulomas and CD severity over a 6-year time period in a large cohort of patients. METHODS: We performed a retrospective study of patients with CD seen at the Inflammatory Bowel Disease Center at the University of Pittsburgh; data were collected from 2009 through 2014 and patients were assigned to groups with and without histologic evidence of granuloma...
December 22, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29276022/brentuximab-vedotin-plus-bendamustine-in-relapsed-or-refractory-hodgkin-s-lymphoma-an-international-multicentre-single-arm-phase-1-2-trial
#14
Owen A O'Connor, Jennifer K Lue, Ahmed Sawas, Jennifer E Amengual, Changchun Deng, Matko Kalac, Lorenzo Falchi, Enrica Marchi, Ithamar Turenne, Renee Lichtenstein, Celeste Rojas, Mark Francescone, Lawrence Schwartz, Bin Cheng, Kerry J Savage, Diego Villa, Michael Crump, Anca Prica, Vishal Kukreti, Serge Cremers, Joseph M Connors, John Kurvuilla
BACKGROUND: Brentuximab vedotin is currently approved for patients with relapsed or refractory Hodgkin's lymphoma who previously received an autologous stem cell transplant or two previous multiagent chemotherapy regimens, and for patients with relapsed or refractory systemic anaplastic large-T-cell lymphoma who previously received at least one chemotherapy regimen. A high proportion of patients with CD30-expressing relapsed or refractory lymphomas have durable responses to single-agent brentuximab vedotin and show longer progression-free survival than do patients treated with chemotherapy...
December 21, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/29217376/safety-tolerability-and-immunogenicity-of-two-zika-virus-dna-vaccine-candidates-in-healthy-adults-randomised-open-label-phase-1-clinical-trials
#15
Martin R Gaudinski, Katherine V Houser, Kaitlyn M Morabito, Zonghui Hu, Galina Yamshchikov, Ro Shauna Rothwell, Nina Berkowitz, Floreliz Mendoza, Jamie G Saunders, Laura Novik, Cynthia S Hendel, LaSonji A Holman, Ingelise J Gordon, Josephine H Cox, Srilatha Edupuganti, Monica A McArthur, Nadine G Rouphael, Kirsten E Lyke, Ginny E Cummings, Sandra Sitar, Robert T Bailer, Bryant M Foreman, Katherine Burgomaster, Rebecca S Pelc, David N Gordon, Christina R DeMaso, Kimberly A Dowd, Carolyn Laurencot, Richard M Schwartz, John R Mascola, Barney S Graham, Theodore C Pierson, Julie E Ledgerwood, Grace L Chen
BACKGROUND: The Zika virus epidemic and associated congenital infections have prompted rapid vaccine development. We assessed two new DNA vaccines expressing premembrane and envelope Zika virus structural proteins. METHODS: We did two phase 1, randomised, open-label trials involving healthy adult volunteers. The VRC 319 trial, done in three centres, assessed plasmid VRC5288 (Zika virus and Japanese encephalitis virus chimera), and the VRC 320, done in one centre, assessed plasmid VRC5283 (wild-type Zika virus)...
December 4, 2017: Lancet
https://www.readbyqxmd.com/read/29214319/electrocardiographic-findings-in-national-basketball-association-athletes
#16
Marc P Waase, R Kannan Mutharasan, William Whang, Marco R DiTullio, John P DiFiori, Lisa Callahan, Jimmie Mancell, Dermot Phelan, Allan Schwartz, Shunichi Homma, David J Engel
Importance: While it is known that long-term intensive athletic training is associated with cardiac structural changes that can be reflected on surface electrocardiograms (ECGs), there is a paucity of sport-specific ECG data. This study seeks to clarify the applicability of existing athlete ECG interpretation criteria to elite basketball players, an athlete group shown to develop significant athletic cardiac remodeling. Objective: To generate normative ECG data for National Basketball Association (NBA) athletes and to assess the accuracy of athlete ECG interpretation criteria in this population...
December 6, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/29209658/surgical-pathology-resident-rotation-restructuring-at-a-tertiary-care-academic-center
#17
Chelsea R Mehr, Amrom E Obstfeld, Amanda C Barrett, Kathleen T Montone, Lauren E Schwartz
Changes in the field of pathology and resident education necessitate ongoing evaluation of residency training. Evolutionary change is particularly important for surgical pathology rotations, which form the core of anatomic pathology training programs. In the past, we organized this rotation based on subjective insight. When faced with the recent need to restructure the rotation, we strove for a more evidence-based process. Our approach involved 2 primary sources of data. We quantified the number of cases and blocks submitted per case type to estimate workload and surveyed residents about the time required to gross specimens in all organ systems...
January 2017: Academic Pathology
https://www.readbyqxmd.com/read/29205070/trends-in-types-of-calls-managed-by-u-s-poison-centers-2000-2015
#18
Bruce D Anderson, Hyunuk Seung, Wendy Klein-Schwartz
AIM: The number of cases reported to poison centers has decreased since 2008 but there is evidence that the complexity of calls is increasing. OBJECTIVES: The objectives are to evaluate national poison center data for trends in reason and how these changes effect management site, medical outcomes, and poison center workload. METHODS: Data regarding reason, age, management site, and medical outcome were extracted from annual reports of the National Poison Data System from 2000 to 2015...
December 5, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/29189523/bilateral-sacral-ala-fractures-are-strongly-associated-with-lumbopelvic-instability
#19
Julius A Bishop, Sean Dangelmajer, Ian Corcoran-Schwartz, Michael J Gardner, Milton L Chip Routt, Tiffany N Castillo
OBJECTIVES: To quantify the incidence of lumbopelvic instability in the setting of unilateral and bilateral sacral fractures and assess whether the presence of bilateral sacral fractures on axial imaging is a useful screening test for lumbopelvic instability. DESIGN: Retrospective case series. SETTING: Level I trauma center at an academic medical center. PATIENTS/PARTICIPANTS: A hospital database was used to identify patients diagnosed with a sacral fracture by The International Classification of Diseases, Ninth Revision (ICD-9) code from 2000 to 2014...
December 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29181796/risk-factors-for-an-elevated-ventricular-end-diastolic-pressure-prior-to-the-fontan-operation
#20
Matthew C Schwartz, Michael A Brock, David Nykanen, William DeCampli
Systemic ventricular end-diastolic pressure (SVEDP) is an important determinant of pulmonary artery pressure in those with a Fontan circulation. Predictors of an elevated SVEDP have been incompletely identified in this population. All who underwent the Fontan operation at our center between 1/2009 and 12/2013 were retrospectively identified. SVEDP at the pre-Fontan catheterization and other patient variables were extracted. We identified 61 patients. Pre-Fontan SVEDP was positively associated with systemic ventricular systolic pressure (β = 0...
November 27, 2017: Pediatric Cardiology
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