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https://www.readbyqxmd.com/read/27920145/three-small-receptive-field-ganglion-cells-in-the-mouse-retina-are-distinctly-tuned-to-size-speed-and-object-motion
#1
Jason Jacoby, Gregory W Schwartz
: Retinal ganglion cells (RGCs) are frequently divided into functional types by their ability to extract and relay specific features from a visual scene, such as the capacity to discern local or global motion, direction of motion, stimulus orientation, contrast or uniformity, or the presence of large or small objects. Here we introduce three previously uncharacterized, non-direction selective ON-OFF RGC types that represent a distinct set of feature detectors in the mouse retina. The three high definition (HD) RGCs possess small receptive field (RF) centers and strong surround suppression...
December 5, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27917575/efficacy-and-tolerability-of-a-new-topical-nitric-zinc-preparation-for-difficult-to-treat-warts
#2
Camila K Janniger, Robert A Schwartz
Treating plantar, periungual, and external genital warts can be challenging. A prospective study from four centers in Italy evaluated 37 immunocompetent patients with single or multiple warts and treated each lesion with a nitric-zinc topical solution composed of organic and inorganic acids meant to devitalize tissue and destroy HPV DNA in infected keratinocytes. Thirty of the 37 patients had external genital warts, two had plantar warts, two had palm and finger warts, and three had subungual warts for a total of 55 lesions treated...
December 5, 2016: Dermatologic Therapy
https://www.readbyqxmd.com/read/27898605/initial-results-of-a-safety-and-feasibility-study-of-auditory-brainstem-implantation-in-congenitally-deaf-children
#3
Eric P Wilkinson, Laurie S Eisenberg, Mark D Krieger, Marc S Schwartz, Margaret Winter, Jamie L Glater, Amy S Martinez, Laurel M Fisher, Robert V Shannon
OBJECTIVE: To determine the safety and feasibility of the auditory brainstem implant (ABI) in congenitally deaf children with cochlear aplasia and/or cochlear nerve deficiency. STUDY DESIGN: Phase I feasibility clinical trial of surgery in 10 children, ages 2 to 5 years, over a 3-year period. SETTING: Tertiary children's hospital and university-based pediatric speech/language/hearing center. INTERVENTION(S): ABI implantation and postsurgical programming...
November 24, 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27893080/travel-associated-zika-virus-disease-acquired-in-the-americas-through-february-2016-a-geosentinel-analysis
#4
Davidson H Hamer, Kira A Barbre, Lin H Chen, Martin P Grobusch, Patricia Schlagenhauf, Abraham Goorhuis, Perry J J van Genderen, Israel Molina, Hilmir Asgeirsson, Phyllis E Kozarsky, Eric Caumes, Stefan H Hagmann, Frank P Mockenhaupt, Gilles Eperon, Elizabeth D Barnett, Emmanuel Bottieau, Andrea K Boggild, Philippe Gautret, Noreen A Hynes, Susan Kuhn, R Ryan Lash, Karin Leder, Michael Libman, Denis J M Malvy, Cecilia Perret, Camilla Rothe, Eli Schwartz, Annelies Wilder-Smith, Martin S Cetron, Douglas H Esposito
Background: Zika virus has spread rapidly in the Americas and has been imported into many nonendemic countries by travelers. Objective: To describe clinical manifestations and epidemiology of Zika virus disease in travelers exposed in the Americas. Design: Descriptive, using GeoSentinel records. Setting: 63 travel and tropical medicine clinics in 30 countries. Patients: Ill returned travelers with a confirmed, probable, or clinically suspected diagnosis of Zika virus disease seen between January 2013 and 29 February 2016...
November 22, 2016: Annals of Internal Medicine
https://www.readbyqxmd.com/read/27876531/patient-centered-quality-of-life-measures-after-alloplastic-temporomandibular-joint-replacement-surgery
#5
X Alakailly, D Schwartz, N Alwanni, C Demko, M A Altay, Y Kilinc, D A Baur, F Quereshy
The purpose of this study was to evaluate patient-reported outcome measures of quality of life (QoL) for patients with end-stage temporomandibular joint (TMJ) disease who have undergone TMJ prosthetic replacement. The records of 36 patients who had undergone alloplastic total joint replacement procedures were analyzed. Patients were treated using either TMJ Concepts or Biomet/Lorenz prosthetics. Patients were asked to complete a 12-item TMJ-S-QoL survey, which encompassed questions pertaining to pain, speech, chewing function, and various aspects of social life and mental health...
November 19, 2016: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27870568/morbidity-and-mortality-differences-between-hematopoietic-cell-transplantation-survivors-and-other-cancer-survivors
#6
Eric J Chow, Kara L Cushing-Haugen, Guang-Shing Cheng, Michael Boeckh, Nandita Khera, Stephanie J Lee, Wendy M Leisenring, Paul J Martin, Beth A Mueller, Stephen M Schwartz, K Scott Baker
Purpose To compare the risks of serious health outcomes among hematopoietic cell transplantation (HCT) survivors versus a matched population of patients with cancer who did not undergo HCT, where the primary difference may be exposure to HCT. Methods Two-year HCT survivors treated at a comprehensive cancer center from 1992 through 2009 who were Washington State residents (n = 1,792; 52% allogeneic and 90% hematologic malignancies) were frequency matched by demographic characteristics and underlying cancer diagnosis (as applicable) to non-HCT 2-year cancer survivors, using the state cancer registry (n = 5,455) and the general population (n = 16,340) using driver's license files...
November 21, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27866323/measuring-compassion-in-healthcare-a-comprehensive-and-critical-review
#7
REVIEW
Shane Sinclair, Lara B Russell, Thomas F Hack, Jane Kondejewski, Richard Sawatzky
BACKGROUND: There is international concern about the lack of compassion in healthcare systems. A valid and reliable tool for measuring compassion in healthcare systems and educational institutions is required. This comprehensive and critical narrative synthesis identified and compared existing measures of compassionate care in clinical settings. METHODS: PubMed, MEDLINE, CINAHL and PsycINFO databases and grey literature were searched to identify studies that report information on instruments that measure compassion or compassionate care in clinicians, nurses, healthcare students and patients...
November 19, 2016: Patient
https://www.readbyqxmd.com/read/27834965/clinical-outcomes-of-gamma-irradiated-sterile-cornea-in-aqueous-drainage-device-surgery-a-multicenter-retrospective-study
#8
Q Pan, H D Jampel, P Ramulu, G F Schwartz, F Cotter, D Cute, Y J Daoud, P Murakami, W J Stark
PurposeThe purpose of the study was to evaluate the safety and efficacy of gamma-irradiated sterile cornea (GISC) for covering the tube in aqueous drainage device (ADD) surgery in a retrospective, multicenter case series.Patients and methodsParticipants included 297 patients (321 procedures) who had undergone ADD surgery for the first time using GISC patch at three clinic centers in the United States between April 2009 and July 2012. The medical records of those consecutive patients were reviewed. Preoperative, intraoperative, and postoperative parameters about GISC were collected and analyzed...
November 11, 2016: Eye
https://www.readbyqxmd.com/read/27824733/outcomes-of-bone-anchored-hearing-aids-baha-for-single-sided-deafness-in-nontraditional-candidates
#9
Seth R Schwartz, Deborah Kobylk
OBJECTIVE: To assess both quality of life (QOL) and hearing outcomes in bone anchored hearing aid (BAHA) users for single sided deafness with 1) less than total hearing loss in the deaf ear, or 2) some degree of hearing loss in the better ear and compare them to traditional candidates. STUDY DESIGN: Prospective comparative cohort study. SETTING: Tertiary referral center. PATIENTS: Patients with a BAHA for single sided deafness were assigned into groups based on hearing thresholds in the deaf ear (> or <90 dBHL) and the control ear (> or <25 dBHL)...
December 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27810938/post-9-11-2001-lung-function-trajectories-by-sex-and-race-in-world-trade-center-exposed-new-york-city-emergency-medical-service-workers
#10
Madeline Vossbrinck, Rachel Zeig-Owens, Charles B Hall, Theresa Schwartz, William Moir, Mayris P Webber, Hillel W Cohen, Anna Nolan, Michael D Weiden, Vasilios Christodoulou, Kerry J Kelly, Thomas K Aldrich, David J Prezant
OBJECTIVE: To determine whether lung function trajectories after 9/11/2001 (9/11) differed by sex or race/ethnicity in World Trade Center-exposed Fire Department of the City of New York emergency medical service (EMS) workers. METHOD: Serial cross-sectional study of pulmonary function tests (PFTs) taken between 9/11 and 9/10/2015. We used data from routine PFTs (forced expiratory volume in 1 s (FEV1) and FEV1% predicted), conducted at 12-18 month intervals. FEV1 and FEV1% predicted were assessed over time, stratified by sex, and race/ethnicity...
November 3, 2016: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27782940/effects-of-obesity-and-leptin-deficiency-on-morphine-pharmacokinetics-in-a-mouse-model
#11
Nicholas M Dalesio, Craig W Hendrix, Douglas Hale McMichael, Carol B Thompson, Carlton K K Lee, Huy Pho, Rafael S Arias, Rachael Rzasa Lynn, Jeffrey Galinkin, Myron Yaster, Robert H Brown, Alan R Schwartz
BACKGROUND: Obesity causes multiorgan dysfunction, specifically metabolic abnormalities in the liver. Obese patients are opioid-sensitive and have high rates of respiratory complications after surgery. Obesity also has been shown to cause resistance to leptin, an adipose-derived hormone that is key in regulating hunger, metabolism, and respiratory stimulation. We hypothesized that obesity and leptin deficiency impair opioid pharmacokinetics (PK) independently of one another. METHODS: Morphine PK were characterized in C57BL/6J wild-type (WT), diet-induced obese (DIO), and leptin-deficient (ob/ob) mice, and in ob/ob mice given leptin-replacement (LR) therapy...
December 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27768856/elevated-serum-tetrac-in-graves-disease-potential-pathogenic-role-in-thyroid-associated-ophthalmopathy
#12
Roshini Fernando, Ekaterina Placzek, Edmund A Reese, Andrew T Placzek, Samantha Schwartz, Aaron Trierweiler, Leslie M Niziol, Stephen Atkins, Thomas S Scanlan, Terry J Smith
CONTEXT: The sources and biological impact of 3,3',5,5' tetraiodothyroacetic acid (TA4) are uncertain. CD34(+) fibrocytes express several proteins involved in the production of thyroid hormones. They infiltrate the orbit in Graves' disease (GD), an autoimmune process known as thyroid-associated ophthalmopathy. It appears that the thyrotropin receptor (TSHR) plays an important role in the pathogenesis of TAO. OBJECTIVE: To quantify levels of TA4 in healthy subjects and those with Graves' disease...
October 21, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27755361/tinnitus-suppression-after-auditory-brainstem-implantation-in-patients-with-neurofibromatosis-type-2
#13
Daniel S Roberts, Steve Otto, Brian Chen, Kevin A Peng, Marc S Schwartz, Derald E Brackmann, John W House
OBJECTIVE: To evaluate whether an auditory brainstem implant (ABI) can impact levels of tinnitus in neurofibromatosis type-2 (NF2) patients who have undergone translabyrinthine craniotomy for vestibular schwannoma (VS) removal and to evaluate the burden of tinnitus in these patients. STUDY DESIGN: A retrospective case series and patient survey. SETTING: Tertiary neurotologic referral center. PATIENTS: NF2 patients who underwent translabyrinthine removal of VS and ABI placement between 1994 and 2015...
October 12, 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27720568/the-impact-of-push-dose-phenylephrine-use-on-subsequent-preload-expansion-in-the-ed-setting
#14
Madison B Schwartz, Jason A Ferreira, Patrick M Aaronson
BACKGROUND: The utilization of bolus-dose phenylephrine (PHE) has transitioned to the emergency department (ED) for the treatment of acutely hypotensive patients, despite a paucity of literature in this setting. METHODS: This was a single center retrospective chart review of the utilization of bolus-dosed PHE for acute hypotension in the ED at an academic non-forprofit hospital. The primary objective of this study is to report the frequency of patients that were initiated on a continuous vasopressor infusion (CVI) within 30 minutes after the first administration of bolus-dose PHE...
September 22, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27716925/auditory-brainstem-implant-program-development
#15
Marc S Schwartz, Eric P Wilkinson
OBJECTIVE: Auditory brainstem implants (ABIs), which have previously been used to restore auditory perception to deaf patients with neurofibromatosis type 2 (NF2), are now being utilized in other situations, including treatment of congenitally deaf children with cochlear malformations or cochlear nerve deficiencies. Concurrent with this expansion of indications, the number of centers placing and expressing interest in placing ABIs has proliferated. Because ABI placement involves posterior fossa craniotomy in order to access the site of implantation on the cochlear nucleus complex of the brainstem and is not without significant risk, we aim to highlight issues important in developing and maintaining successful ABI programs that would be in the best interests of patients...
September 26, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27704027/clinical-characteristics-and-outcomes-among-individuals-with-spinal-implant-infections-a-descriptive-study
#16
Sanjiv M Baxi, Makeda L Robinson, Marie F Grill, Brian S Schwartz, Sarah B Doernberg, Catherine Liu
Little is known about the clinical presentation and outcomes associated with spinal implant infections. Here, we describe a single center's experience in a retrospective cohort of 109 individuals with spinal implant infections, including clinical, microbiological, therapeutic, and outcome data.
September 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27695987/variation-in-estimated-glomerular-filtration-rate-at-dialysis-initiation-in-children
#17
Allison B Dart, Michael Zappitelli, Manish M Sood, R Todd Alexander, Steven Arora, Robin L Erickson, Kristine Kroeker, Andrea Soo, Braden J Manns, Susan M Samuel
BACKGROUND: Data guiding the timing of dialysis initiation in children are limited. We sought to determine current practice and secular trends in Canada with respect to the timing of dialysis initiation in children based on estimated glomerular filtration rate (eGFR). METHODS: This observational study included incident chronic dialysis patients aged ≤21 years identified from the Canadian Organ Replacement Register who started dialysis in Canada between January 2001 and December 2010 at any of the nine participating Canadian centers (n = 583)...
October 1, 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/27695647/chemotherapy-for-elderly-ovarian-cancer-patients
#18
Sivraj Muralikrishnan, Christos Hatzis, Andrea Katz, Alessandro Santin, Peter E Schwartz, Maysa M Abu-Khalaf
OBJECTIVE: Ovarian cancer is the most lethal cancer involving the female pelvic reproductive system. Its incidence increases with age and with an aging population, its prevalence should also increase. The goal of our retrospective study is to report our experience in treating women over 65 years of age, with a diagnosis of primary ovarian cancer, using standard intravenous chemotherapy. METHODS: The medical records of 78 patients>65 years of age diagnosed with primary ovarian cancer at the Yale Cancer Center between 1996-2006 were retrospectively reviewed and included in our analysis...
August 2016: Gynecology & Obstetrics: Current Research
https://www.readbyqxmd.com/read/27661788/patient-centered-methadone-treatment-a-randomized-clinical-trial
#19
Robert P Schwartz, Sharon M Kelly, Shannon G Mitchell, Jan Gryczynski, Kevin E O'Grady, Devang Gandhi, Yngvild Olsen, Jerome H Jaffe
BACKGROUND AND AIMS: Methadone patients who discontinue treatment are at high risk of relapse, yet a substantial proportion discontinue treatment within the first year. We investigated whether a patient-centered approach to methadone treatment improved participant outcomes at 12 months following admission, compared with methadone treatment-as-usual. DESIGN: Two-arm open-label randomized trial. SETTING: Two methadone treatment programs (MTPs) in Baltimore, MD, USA...
September 23, 2016: Addiction
https://www.readbyqxmd.com/read/27660409/update-on-corticosteroids-for-diabetic-macular-edema
#20
REVIEW
Stephen G Schwartz, Ingrid U Scott, Michael W Stewart, Harry W Flynn
Diabetic macular edema (DME) remains an important cause of visual loss. Although anti-vascular endothelial growth factor (VEGF) agents are generally used as first-line treatments for patients with center-involving DME, there is an important role for corticosteroids as well. Corticosteroids may be especially useful in pseudophakic patients poorly responsive to anti-VEGF therapies, in patients wishing to reduce the number of required injections, and in pregnant patients. Intravitreal triamcinolone acetonide has been used for many years but is not approved for this indication...
2016: Clinical Ophthalmology
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