Lorenz Balcar, Benedikt Simbrunner, Rafael Paternostro, Mathias Jachs, Lukas Hartl, Georg Semmler, Benedikt Silvester Hofer, Albert Friedrich Stättermayer, Matthias Pinter, Ton Lisman, Michael Trauner, Peter Quehenberger, Thomas Reiberger, Bernhard Scheiner, Mattias Mandorfer
BACKGROUND & AIMS: Increased aggregation of individual platelets upon activation, as assessed by whole blood aggregometry standardised to platelet count (PLT), has recently been linked to progression of advanced chronic liver disease (ACLD). Moreover, changes in primary haemostasis have been implicated in bleeding and thrombosis in patients with ACLD.We aimed (i) to identify the determinants of the primary haemostatic capacity - as assessed by Platelet Function Analyzer 100 (PFA-100) (' in vitro bleeding time') - in patients with ACLD and (ii) to investigate its potential association with clinical outcomes...
January 2024: JHEP reports: innovation in hepatology