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https://www.readbyqxmd.com/read/27901493/has-aidi-injection-the-attenuation-and-synergistic-efficacy-to-gemcitabine-and-cisplatin-in-non-small-cell-lung-cancer-a-meta-analysis-of-36-randomized-controlled-trials
#1
Zheng Xiao, Chengqiong Wang, Ling Chen, Xuemei Tang, Lianhong Li, Nana Li, Jing Li, Qihai Gong, Fushan Tang, Jihong Feng, Xiaofei Li
Gemcitabine and cisplatin is the first line chemotherapy for non-small cell lung cancer with high toxicity. Aidi injection is a cantharidin and astragalu-based Chinese herbs injection in China. Has Aidi injection attenuation and synergistic efficacy to GP in NSCLC? There is lack of strong evidence to prove it. To further reveal it, we systematically evaluated all related studies. We collected all studies about Aidi injection plus GP for NSCLC in Medline, Embase, Web of Science, CNKI, VIP, Wanfang Database, CBM, CCRCT, Chi-CTR, and US-clinical trials (established to June 2015)...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27881011/adjuvant-chemotherapy-with-bevacizumab-i-p-can-prolong-survival-time-of-patients-with-advanced-ovarian-cancer-after-cytoreduction
#2
F DU, P Li, J Chen, Z Gong, C Chi, B Hu, H Chu
Objective To assess whether adjuvant chemotherapy with bevacizumab intraperitoneal (i.p.) is better than adjuvant chemotherapy with bevacizumab intravenous (i.v.) or adjuvant chemotherapy only for patients with advanced ovarian cancer after cytoreduction. Selected patients with advanced ovarian cancer after cytoreduction were divided into three groups depend on their will: adjuvant chemotherapy only; adjuvant chemotherapy combined with bevacizumab intravenous (i.v.); adjuvant chemotherapy combined with bevacizumab intraperitoneal (i...
November 24, 2016: Neoplasma
https://www.readbyqxmd.com/read/27873157/eicosapentaenoic-acid-triggers-ca-2-release-and-ca-2-influx-in-mouse-cerebral-cortex-endothelial-bend-3-cells
#3
King-Chuen Wu, Kar-Lok Wong, Mei-Ling Wang, Lian-Ru Shiao, Iat-Lon Leong, Chi-Li Gong, Ka-Shun Cheng, Paul Chan, Yuk-Man Leung
Eicosapentaenoic acid (EPA), an omega-3 fatty acid abundant in fish oil, protects endothelial cells (EC) from lipotoxicity and triggers EC NO release. The latter is related to an elevation of cytosolic Ca(2+). Although EPA has been shown to cause human EC cytosolic Ca(2+) elevation, the mechanism is unclear. Microfluorimetric imaging was used here to measure free cytosolic Ca(2+) concentration. EPA was shown to cause intracellular Ca(2+) release in mouse cerebral cortex endothelial bEND.3 cells; interestingly, the EPA-sensitive intracellular Ca(2+) pool(s) appeared to encompass and was larger than the Ca(2+) pool mobilized by sarcoplasmic-endoplasmic reticulum Ca(2+)-ATPase inhibition by cyclopiazonic acid...
November 21, 2016: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/27829869/interaction-between-thalamus-and-hippocampus-in-termination-of-amygdala-kindled-seizures-in-mice
#4
Zhen Zhang, Jia-Jia Li, Qin-Chi Lu, Hai-Qing Gong, Pei-Ji Liang, Pu-Ming Zhang
The thalamus and hippocampus have been found both involved in the initiation, propagation, and termination of temporal lobe epilepsy. However, the interaction of these regions during seizures is not clear. The present study is to explore whether some regular patterns exist in their interaction during the termination of seizures. Multichannel in vivo recording techniques were used to record the neural activities from the cornu ammonis 1 (CA1) of hippocampus and mediodorsal thalamus (MDT) in mice. The mice were kindled by electrically stimulating basolateral amygdala neurons, and Racine's rank standard was employed to classify the stage of behavioral responses (stage 1~5)...
2016: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/27810048/patient-specific-and-genome-edited-induced-pluripotent-stem-cell-derived-cardiomyocytes-elucidate-single-cell-phenotype-of-brugada-syndrome
#5
Ping Liang, Karim Sallam, Haodi Wu, Yingxin Li, Ilanit Itzhaki, Priyanka Garg, Ying Zhang, Vittavat Vermglinchan, Feng Lan, Mingxia Gu, Tingyu Gong, Yan Zhuge, Chunjiang He, Antje D Ebert, Veronica Sanchez-Freire, Jared Churko, Shijun Hu, Arun Sharma, Chi Keung Lam, Melvin M Scheinman, Donald M Bers, Joseph C Wu
BACKGROUND: Brugada syndrome (BrS), a disorder associated with characteristic electrocardiogram precordial ST-segment elevation, predisposes afflicted patients to ventricular fibrillation and sudden cardiac death. Despite marked achievements in outlining the organ level pathophysiology of the disorder, the understanding of human cellular phenotype has lagged due to a lack of adequate human cellular models of the disorder. OBJECTIVES: The objective of this study was to examine single cell mechanism of Brugada syndrome using induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs)...
November 8, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27809506/annulative-methods-enable-a-total-synthesis-of-the-complex-meroterpene-berkeleyone-a
#6
Chi P Ting, Gong Xu, Xianhuang Zeng, Thomas J Maimone
Synthetic pathways to complex meroterpenes derived from 3,5-dimethylorsellinic acid (DMOA) and farnesyl pyrophosphate have not been reported despite heavy biosynthetic and medicinal interest. Herein we report a concise, 13-step total synthesis of berkeleyone A, a potential gateway compound to a plethora of fungal-derived meroterpenes. In addition, we have developed a novel annulation reaction for the assembly of hydroxylated 1,3-cyclohexadiones in a single step.
November 3, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27748940/multivariate-analysis-of-metastasis%C3%A2-related-risk-factors-for-patients-with-gastroenteropancreatic-neuroendocrine-tumors-based-on-clinicopathological-and-endoscopic-features
#7
Caiyun Tang, Lingqi Gong, Wenli Zou, Jie Zhang, Yuqian Zhou, Xiaoping Wu, Fanggen Lu, Chunhui Ouyang, Xiaowei Liu
Gastroenteropancreatic neuroendocrine tumors (GEP‑NETs) are relatively uncommon. Unfortunately, epidemiological studies on the incidence of GEP‑NETs worldwide have reported a marked increase in the detection of these tumors. Although they often exhibit relatively indolent clinical courses, GEP‑NETs have the potential for lethal progression, especially in patients who present with advanced disease. Early detection and surgical removal is currently the only reliable curative treatment for GEP‑NET patients...
October 13, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27720395/fenofibrate-inhibits-cytochrome-p450-epoxygenase-2c-activity-to-suppress-pathological-ocular-angiogenesis
#8
Yan Gong, Zhuo Shao, Zhongjie Fu, Matthew L Edin, Ye Sun, Raffael G Liegl, Zhongxiao Wang, Chi-Hsiu Liu, Samuel B Burnim, Steven S Meng, Fred B Lih, John Paul SanGiovanni, Darryl C Zeldin, Ann Hellström, Lois E H Smith
Neovascular eye diseases including retinopathy of prematurity, diabetic retinopathy and age-related-macular-degeneration are major causes of blindness. Fenofibrate treatment in type 2 diabetes patients reduces progression of diabetic retinopathy independent of its peroxisome proliferator-activated receptor (PPAR)α agonist lipid lowering effect. The mechanism is unknown. Fenofibrate binds to and inhibits cytochrome P450 epoxygenase (CYP)2C with higher affinity than to PPARα. CYP2C metabolizes ω-3 long-chain polyunsaturated fatty acids (LCPUFAs)...
September 30, 2016: EBioMedicine
https://www.readbyqxmd.com/read/27688180/design-and-discovery-of-4-anilinoquinazoline-urea-derivatives-as-dual-tk-inhibitors-of-egfr-and-vegfr-2
#9
Hai-Qi Zhang, Fei-Hu Gong, Ji-Qing Ye, Chi Zhang, Xiao-Hong Yue, Chuan-Gui Li, Yun-Gen Xu, Li-Ping Sun
EGFR and VEGFR-2 are involved in pathological disorders and the progression of different kinds of tumors, the combined blockade of EGFR and VEGFR signaling pathways appears to be an attractive approach to cancer therapy. In this work, a series of 4-anilinoquinazoline derivatives containing substituted diaryl urea or glycine methyl ester moiety were designed and identified as EGFR and VEGFR-2 dual inhibitors. Compounds 19i, 19j and 19l exhibited the most potent inhibitory activities against EGFR (IC50 = 1 nM, 78 nM and 51 nM, respectively) and VEGFR-2 (IC50 = 79 nM, 14 nM and 14 nM, respectively), they showed good antiproliferative activities as well...
September 14, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27684953/quantitative-proteomic-profiling-the-molecular-signatures-of-annexin-a5-in-lung-squamous-carcinoma-cells
#10
Bing Sun, Yuxin Bai, Liyuan Zhang, Linlin Gong, Xiaoyu Qi, Huizhen Li, Faming Wang, Xinming Chi, Yulin Jiang, Shujuan Shao
Lung cancer remains the leading cancer killer around the world. It's crucial to identify newer mechanism-based targets to effectively manage lung cancer. Annexin A5 (ANXA5) is a protein kinase C inhibitory protein and calcium dependent phospholipid-binding protein, which may act as an endogenous regulator of various pathophysiological processes. However, its molecular mechanism in lung cancer remains poorly understood. This study was designed to determine the mechanism of ANXA5 in lung cancer with a hope to obtain useful information to provide a new therapeutic target...
2016: PloS One
https://www.readbyqxmd.com/read/27684936/correction-efficient-removal-of-co2-from-aqueous-solution-by-3-aminopropyltriethoxysilane-functionalized-montmorillonite-with-enhanced-adsorption-capacity
#11
Zhujian Huang, Pingxiao Wu, Beini Gong, Yaping Dai, Pen-Chi Chiang, Xiaolin Lai, Guangwei Yu
[This corrects the article DOI: 10.1371/journal.pone.0159802.].
2016: PloS One
https://www.readbyqxmd.com/read/27647066/-inventory-building-of-phages-against-extensively-drug-resistant-acinetobacter-baumannii-isolated-from-wounds-of-patients-with-severe-burn-and-related-characteristic-analysis
#12
Z C Yang, L Y Deng, Y L Gong, S P Yin, B Jiang, G T Huang, Y Z Peng, F Q Hu
Objective: To build inventory of phages against extensively drug-resistant Acinetobacter Baumannii isolated from wounds of inpatients of burn ICU and analyze related characteristics. Methods: In 2014 and 2015, 131 strains of extensively drug-resistant Acinetobacter Baumannii were isolated from wounds of inpatients of burn ICU from one hospital in Chongqing. In 2015, 98 strains of extensively drug-resistant Acinetobacter Baumannii were isolated from wounds of inpatients of burn ICU from 6 hospitals in Guangdong province...
September 20, 2016: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/27646279/mind-body-interventions-for-irritable-bowel-syndrome-patients-in-the-chinese-population-a-systematic-review-and-meta-analysis
#13
Weidong Wang, Fang Wang, Feng Fan, Ana Cristina Sedas, Jian Wang
PURPOSE: The aim of this study is to identify and assess evidence related to the efficacy of mind-body interventions on irritable bowel syndrome (IBS) in the Chinese population. METHOD: Drawn from Chinese databases, nine RCTs and three Q-E studies were included in the systematic review. The methodological quality of RCTs was evaluated based on the following criteria: adequate sequence generation, allocation concealment, blinding, completeness of outcome data, selective reporting, and other potential biases...
September 19, 2016: International Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/27633146/community-composition-of-photosynthetic-picoeukaryotes-in-a-subtropical-coastal-ecosystem-with-particular-emphasis-on-micromonas
#14
Yun-Chi Lin, Chih-Ching Chung, Liang-Yin Chen, Gwo-Ching Gong, Chin-Yi Huang, Kuo-Ping Chiang
Photosynthetic picoeukaryotes (PPEs) are important constituents in picoplankton communities in many marine ecosystems. However, little is known about their community composition in the subtropical coastal waters of the Northwestern Pacific Ocean. In order to study their taxonomic composition, this study constructed 18S rRNA gene libraries using flow cytometric sorting during the warm season. The results show that, after diatoms, prasinophyte clones are numerically dominant. Within prasinophytes, Micromonas produced the most common sequences, and included clades II, III, IV, and VI...
September 16, 2016: Journal of Eukaryotic Microbiology
https://www.readbyqxmd.com/read/27621633/investigation-on-internet-addiction-disorder-in-adolescents-in-anhui-people-s-republic-of-china
#15
Yan Chen, Yaowen Kang, Weizhi Gong, Lianping He, Yuelong Jin, Xiaoyue Zhu, Yingshui Yao
BACKGROUND AND AIM: The purpose of this study was to describe the characteristics and prevalence of Internet addiction (IA) in adolescents so as to provide a scientific basis for the communities, schools, and families. METHODS: We conducted a survey by randomized cluster sampling on 5,249 students, grades ranging from 7 to 12, in Anhui province, People's Republic of China. The questionnaire consisted of general information and IA test. Chi-square test was used to compare the status of IA disorder (IAD)...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27583423/complementary-integrative-therapies-that-work-a-review-of-the-evidence
#16
Benjamin Kligler, Raymond Teets, Melissa Quick
Significant evidence supports the effectiveness and safety of several complementary or integrative treatment approaches to common primary care problems. Acupuncture is effective in the management of chronic low back pain. Mind-body interventions such as cognitive behavior therapy, yoga, tai chi, qi gong, and music therapy may be helpful for treating insomnia. Exercise can reduce anxiety symptoms. Herbal preparations and nutritional supplements can be useful as first-line therapy for certain conditions, such as fish oil for hypertriglyceridemia, St...
September 1, 2016: American Family Physician
https://www.readbyqxmd.com/read/27566079/baicalin-scavenged-reactive-oxygen-species-and-protected-human-keratinocytes-against-uvb-induced-cytotoxicity
#17
Wen-Shin Chang, En-Yuan Lin, Shih-Wei Hsu, Pei-Shin Hu, Chin-Liang Chuang, Cheng-Hsi Liao, Chun-Kai Fu, Chung-Hao Su, Chi-Li Gong, Chieh-Lun Hsiao, DA-Tian Bau, Chia-Wen Tsai
Ultraviolet B (UVB), with a wavelength of 280-320 nm, represents one of the most important environmental factors for skin disorders, including sunburn, hyperpigmentation, solar keratosis, solar elastosis and skin cancer. Therefore, protection against excessive UVA-induced damage is useful for prevention of sunburn and other human diseases. Baicalin, a major component of traditional Chinese medicine Scutellaria baicalensis, has been reported to possess antioxidant and cytostatic capacities. In this study, we examined whether baicalin is also capable of protecting human keratinocytes from UVB irradiation...
September 2016: In Vivo
https://www.readbyqxmd.com/read/27548402/two-dimensional-chirality-transfer-via-on-surface-reaction
#18
Haiming Zhang, Zhongmiao Gong, Kewei Sun, Ruomeng Duan, Penghui Ji, Ling Li, Chen Li, Klaus Müllen, Lifeng Chi
Two-dimensional chirality transfer from self-assembled (SA) molecules to covalently bonded products was achieved via on-surface synthesis on Au(111) substrates by choosing 1,4-dibromo-2,5-didodecylbenzene (12DB) and 1,4-dibromo-2,5-ditridecylbenzene (13DB) as designed precursors. Scanning tunneling microscopy investigations reveal that their aryl-aryl coupling reaction occurs by connecting the nearest neighboring precursors and thus preserving the SA lamellar structure. The SA structures of 12(13)DB precursors determine the final structures of produced oligo-p-phenylenes (OPP) on the surface...
September 14, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27542262/elevated-eukaryotic-elongation-factor-2-expression-is-involved-in-proliferation-and-invasion-of-lung-squamous-cell-carcinoma
#19
Yang Song, Bing Sun, LiHong Hao, Jun Hu, Sha Du, Xin Zhou, LiYuan Zhang, Lu Liu, LinLin Gong, XinMing Chi, Qiang Liu, ShuJuan Shao
Eukaryotic elongation factor 2 (EF2), is a critical enzyme solely responsible for catalyzing the translocation of the elongated peptidyl-tRNA from the A to P sites of the ribosome during the process of protein synthesis. EF2 is found to be highly expressed in a variety of malignant tumors and is correlated with cancer cell progression and recurrence. The present study was designed to uncover the function of EF2 on lung squamous cell carcinoma (LSCC) cancer cell growth and progression. Our results from clinical tissue studies showed that EF2 protein was significantly overexpressed in LSCC tissues, compared with the adjacent normal lung tissues, which was confirmed by western blotting and tissue microarray...
August 16, 2016: Oncotarget
https://www.readbyqxmd.com/read/27524797/pharmacologic-activation-of-wnt-signaling-by-lithium-normalizes-retinal-vasculature-in-a-murine-model-of-familial-exudative-vitreoretinopathy
#20
Zhongxiao Wang, Chi-Hsiu Liu, Ye Sun, Yan Gong, Tara L Favazza, Peyton C Morss, Nicholas J Saba, Thomas W Fredrick, Xi He, James D Akula, Jing Chen
Familial exudative vitreoretinopathy (FEVR) is characterized by delayed retinal vascular development, which promotes hypoxia-induced pathologic vessels. In severe cases FEVR may lead to retinal detachment and visual impairment. Genetic studies linked FEVR with mutations in Wnt signaling ligand or receptors, including low-density lipoprotein receptor-related protein 5 (LRP5) gene. Here, we investigated ocular pathologies in a Lrp5 knockout (Lrp5(-/-)) mouse model of FEVR and explored whether treatment with a pharmacologic Wnt activator lithium could bypass the genetic defects, thereby protecting against eye pathologies...
October 2016: American Journal of Pathology
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