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Caiyun Tang, Lingqi Gong, Wenli Zou, Jie Zhang, Yuqian Zhou, Xiaoping Wu, Fanggen Lu, Chunhui Ouyang, Xiaowei Liu
Gastroenteropancreatic neuroendocrine tumors (GEP‑NETs) are relatively uncommon. Unfortunately, epidemiological studies on the incidence of GEP‑NETs worldwide have reported a marked increase in the detection of these tumors. Although they often exhibit relatively indolent clinical courses, GEP‑NETs have the potential for lethal progression, especially in patients who present with advanced disease. Early detection and surgical removal is currently the only reliable curative treatment for GEP‑NET patients...
October 13, 2016: Oncology Reports
Yan Gong, Zhuo Shao, Zhongjie Fu, Matthew L Edin, Ye Sun, Raffael G Liegl, Zhongxiao Wang, Chi-Hsiu Liu, Samuel B Burnim, Steven S Meng, Fred B Lih, John Paul SanGiovanni, Darryl C Zeldin, Ann Hellström, Lois E H Smith
Neovascular eye diseases including retinopathy of prematurity, diabetic retinopathy and age-related-macular-degeneration are major causes of blindness. Fenofibrate treatment in type 2 diabetes patients reduces progression of diabetic retinopathy independent of its peroxisome proliferator-activated receptor (PPAR)α agonist lipid lowering effect. The mechanism is unknown. Fenofibrate binds to and inhibits cytochrome P450 epoxygenase (CYP)2C with higher affinity than to PPARα. CYP2C metabolizes ω-3 long-chain polyunsaturated fatty acids (LCPUFAs)...
September 30, 2016: EBioMedicine
Hai-Qi Zhang, Fei-Hu Gong, Ji-Qing Ye, Chi Zhang, Xiao-Hong Yue, Chuan-Gui Li, Yun-Gen Xu, Li-Ping Sun
EGFR and VEGFR-2 are involved in pathological disorders and the progression of different kinds of tumors, the combined blockade of EGFR and VEGFR signaling pathways appears to be an attractive approach to cancer therapy. In this work, a series of 4-anilinoquinazoline derivatives containing substituted diaryl urea or glycine methyl ester moiety were designed and identified as EGFR and VEGFR-2 dual inhibitors. Compounds 19i, 19j and 19l exhibited the most potent inhibitory activities against EGFR (IC50 = 1 nM, 78 nM and 51 nM, respectively) and VEGFR-2 (IC50 = 79 nM, 14 nM and 14 nM, respectively), they showed good antiproliferative activities as well...
September 14, 2016: European Journal of Medicinal Chemistry
Bing Sun, Yuxin Bai, Liyuan Zhang, Linlin Gong, Xiaoyu Qi, Huizhen Li, Faming Wang, Xinming Chi, Yulin Jiang, Shujuan Shao
Lung cancer remains the leading cancer killer around the world. It's crucial to identify newer mechanism-based targets to effectively manage lung cancer. Annexin A5 (ANXA5) is a protein kinase C inhibitory protein and calcium dependent phospholipid-binding protein, which may act as an endogenous regulator of various pathophysiological processes. However, its molecular mechanism in lung cancer remains poorly understood. This study was designed to determine the mechanism of ANXA5 in lung cancer with a hope to obtain useful information to provide a new therapeutic target...
2016: PloS One
Zhujian Huang, Pingxiao Wu, Beini Gong, Yaping Dai, Pen-Chi Chiang, Xiaolin Lai, Guangwei Yu
[This corrects the article DOI: 10.1371/journal.pone.0159802.].
2016: PloS One
Z C Yang, L Y Deng, Y L Gong, S P Yin, B Jiang, G T Huang, Y Z Peng, F Q Hu
Objective: To build inventory of phages against extensively drug-resistant Acinetobacter Baumannii isolated from wounds of inpatients of burn ICU and analyze related characteristics. Methods: In 2014 and 2015, 131 strains of extensively drug-resistant Acinetobacter Baumannii were isolated from wounds of inpatients of burn ICU from one hospital in Chongqing. In 2015, 98 strains of extensively drug-resistant Acinetobacter Baumannii were isolated from wounds of inpatients of burn ICU from 6 hospitals in Guangdong province...
September 20, 2016: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
Weidong Wang, Fang Wang, Feng Fan, Ana Cristina Sedas, Jian Wang
PURPOSE: The aim of this study is to identify and assess evidence related to the efficacy of mind-body interventions on irritable bowel syndrome (IBS) in the Chinese population. METHOD: Drawn from Chinese databases, nine RCTs and three Q-E studies were included in the systematic review. The methodological quality of RCTs was evaluated based on the following criteria: adequate sequence generation, allocation concealment, blinding, completeness of outcome data, selective reporting, and other potential biases...
September 19, 2016: International Journal of Behavioral Medicine
Yun-Chi Lin, Chih-Ching Chung, Liang-Yin Chen, Gwo-Ching Gong, Chin-Yi Huang, Kuo-Ping Chiang
Photosynthetic picoeukaryotes (PPEs) are important constituents in picoplankton communities in many marine ecosystems. However, little is known about their community composition in the subtropical coastal waters of the Northwestern Pacific Ocean. In order to study their taxonomic composition, this study constructed 18S rRNA gene libraries using flow cytometric sorting during the warm season. The results show that, after diatoms, prasinophyte clones are numerically dominant. Within prasinophytes, Micromonas produced the most common sequences, and included clades II, III, IV, and VI...
September 16, 2016: Journal of Eukaryotic Microbiology
Yan Chen, Yaowen Kang, Weizhi Gong, Lianping He, Yuelong Jin, Xiaoyue Zhu, Yingshui Yao
BACKGROUND AND AIM: The purpose of this study was to describe the characteristics and prevalence of Internet addiction (IA) in adolescents so as to provide a scientific basis for the communities, schools, and families. METHODS: We conducted a survey by randomized cluster sampling on 5,249 students, grades ranging from 7 to 12, in Anhui province, People's Republic of China. The questionnaire consisted of general information and IA test. Chi-square test was used to compare the status of IA disorder (IAD)...
2016: Neuropsychiatric Disease and Treatment
Benjamin Kligler, Raymond Teets, Melissa Quick
Significant evidence supports the effectiveness and safety of several complementary or integrative treatment approaches to common primary care problems. Acupuncture is effective in the management of chronic low back pain. Mind-body interventions such as cognitive behavior therapy, yoga, tai chi, qi gong, and music therapy may be helpful for treating insomnia. Exercise can reduce anxiety symptoms. Herbal preparations and nutritional supplements can be useful as first-line therapy for certain conditions, such as fish oil for hypertriglyceridemia, St...
September 1, 2016: American Family Physician
Wen-Shin Chang, En-Yuan Lin, Shih-Wei Hsu, Pei-Shin Hu, Chin-Liang Chuang, Cheng-Hsi Liao, Chun-Kai Fu, Chung-Hao Su, Chi-Li Gong, Chieh-Lun Hsiao, DA-Tian Bau, Chia-Wen Tsai
Ultraviolet B (UVB), with a wavelength of 280-320 nm, represents one of the most important environmental factors for skin disorders, including sunburn, hyperpigmentation, solar keratosis, solar elastosis and skin cancer. Therefore, protection against excessive UVA-induced damage is useful for prevention of sunburn and other human diseases. Baicalin, a major component of traditional Chinese medicine Scutellaria baicalensis, has been reported to possess antioxidant and cytostatic capacities. In this study, we examined whether baicalin is also capable of protecting human keratinocytes from UVB irradiation...
September 2016: In Vivo
Haiming Zhang, Zhongmiao Gong, Kewei Sun, Ruomeng Duan, Penghui Ji, Ling Li, Chen Li, Klaus Müllen, Lifeng Chi
Two-dimensional chirality transfer from self-assembled (SA) molecules to covalently bonded products was achieved via on-surface synthesis on Au(111) substrates by choosing 1,4-dibromo-2,5-didodecylbenzene (12DB) and 1,4-dibromo-2,5-ditridecylbenzene (13DB) as designed precursors. Scanning tunneling microscopy investigations reveal that their aryl-aryl coupling reaction occurs by connecting the nearest neighboring precursors and thus preserving the SA lamellar structure. The SA structures of 12(13)DB precursors determine the final structures of produced oligo-p-phenylenes (OPP) on the surface...
September 14, 2016: Journal of the American Chemical Society
Yang Song, Bing Sun, LiHong Hao, Jun Hu, Sha Du, Xin Zhou, LiYuan Zhang, Lu Liu, LinLin Gong, XinMing Chi, Qiang Liu, ShuJuan Shao
Eukaryotic elongation factor 2 (EF2), is a critical enzyme solely responsible for catalyzing the translocation of the elongated peptidyl-tRNA from the A to P sites of the ribosome during the process of protein synthesis. EF2 is found to be highly expressed in a variety of malignant tumors and is correlated with cancer cell progression and recurrence. The present study was designed to uncover the function of EF2 on lung squamous cell carcinoma (LSCC) cancer cell growth and progression. Our results from clinical tissue studies showed that EF2 protein was significantly overexpressed in LSCC tissues, compared with the adjacent normal lung tissues, which was confirmed by western blotting and tissue microarray...
August 16, 2016: Oncotarget
Zhongxiao Wang, Chi-Hsiu Liu, Ye Sun, Yan Gong, Tara L Favazza, Peyton C Morss, Nicholas J Saba, Thomas W Fredrick, Xi He, James D Akula, Jing Chen
Familial exudative vitreoretinopathy (FEVR) is characterized by delayed retinal vascular development, which promotes hypoxia-induced pathologic vessels. In severe cases FEVR may lead to retinal detachment and visual impairment. Genetic studies linked FEVR with mutations in Wnt signaling ligand or receptors, including low-density lipoprotein receptor-related protein 5 (LRP5) gene. Here, we investigated ocular pathologies in a Lrp5 knockout (Lrp5(-/-)) mouse model of FEVR and explored whether treatment with a pharmacologic Wnt activator lithium could bypass the genetic defects, thereby protecting against eye pathologies...
October 2016: American Journal of Pathology
Zhihong Gong, Chi-Chen Hong, Elisa V Bandera, Lucile L Adams-Campbell, Melissa A Troester, Song-Yi Park, Kathryn A McInerney, Gary Zirpoli, Andrew F Olshan, Julie R Palmer, Christine B Ambrosone, Lynn Rosenberg
The relationship between physical activity and breast cancer risk has been extensively studied among women of European descent, with most studies reporting inverse associations. However, data on American women of African ancestry (AA) and by tumor subtypes are sparse. Thus, we examined associations of vigorous exercise and breast cancer risk overall, and by estrogen receptor (ER) status, in the African American Breast Cancer Epidemiology and Risk Consortium. We pooled data from four large studies on 2482 ER+ cases, 1374 ER- cases, and 16,959 controls...
September 2016: Breast Cancer Research and Treatment
Huai-Yung Wang, Yu-Chieh Chi, Gong-Ru Lin
A novel millimeter-wave radio over fiber (MMW-RoF) link at carrier frequency of 35-GHz is proposed with the use of remotely beating MMW generation from reference master and injected slave colorless laser diode (LD) carriers at orthogonally polarized dual-wavelength injection-locking. The slave colorless LD supports lasing one of the dual-wavelength master modes with orthogonal polarizations, which facilitates the single-mode direct modulation of the quadrature amplitude modulation (QAM) orthogonal frequency division multiplexing (OFDM) data...
August 8, 2016: Optics Express
Young-Hee Jeong, Hanlin Lu, Chi-Hun Park, Meiyan Li, Huijuan Luo, Joung Joo Kim, Siyang Liu, Kyeong Hee Ko, Shujia Huang, In Sung Hwang, Mi Na Kang, Desheng Gong, Kang Bae Park, Eun Ji Choi, Jung Hyun Park, Yeon Woo Jeong, Changjong Moon, Sang-Hwan Hyun, Nam Hyung Kim, Eui-Bae Jeung, Huanming Yang, Woo Suk Hwang, Fei Gao
Somatic cell nuclear transfer (SCNT) provides an excellent model for studying epigenomic reprogramming during mammalian development. We mapped the whole genome and whole methylome for potential anomalies of mutations or epimutations in SCNT-generated dogs with XY chromosomal sex but complete gonadal dysgenesis, which is classified as 78, XY disorder of sex development (DSD). Whole genome sequencing revealed no potential genomic variations that could explain the pathogenesis of DSD. However, extensive but stochastic anomalies of genome-wide DNA methylation were discovered in these SCNT DSD dogs...
2016: Scientific Reports
(no author information available yet)
Due to an overlook on the author's side, author's affiliation in the article entitled as: "Methylphenidate on Cognitive Improvement in Patients with Traumatic Brain Injury: A Meta-Analysis" by Dr. Chi-Hsien Huang (Co-author) published in the journal "Current Neuropharmacology" Volume 14, No 3, Page no- 272-281 was incomplete.
2016: Current Neuropharmacology
Li Gong, Chongjuan Wang, Yuan Gao, Jie Wang
OBJECTIVE: MicroRNA-148a (MiR-148a) had been reported to take part in some cancer progresses, but its clinical significance in ovarian cancer had been rarely reported. The purpose of this study was to evaluate the prognostic value of miR-148a as well as its roles in ovarian cancer progression. METHODS: Relative expression of miR-148a in the plasma specimens of ovarian cancer patients was detected by qRT-PCR. Chi-square test was used to analyze the relationship between miR-148a expression and clinical characteristics...
June 22, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Maoxin Wang, Yilong Xu, Xianming Chen, Hui Chen, Hongxun Gong, Shiyan Chen
BACKGROUND: Nasopharyngeal carcinoma is the most frequently diagnosed primary tumor originating from the nasopharynx, and the preferred treatment modality is radiotherapy. AIMS: To identify nasopharyngeal carcinoma prognostic factors in patients with residual or recurrent cervical lymph node metastases after radiotherapy. PATIENTS AND METHODS: The clinicopathologic characteristics and prognoses of 67 nasopharyngeal carcinoma patients with residual or recurrent cervical lymph node metastases who were diagnosed and treated were analyzed retrospectively...
April 2016: Journal of Cancer Research and Therapeutics
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