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Yuejiao Chen, Bingang Xu, Jianfeng Wen, Jianliang Gong, Tao Hua, Chi-Wai Kan, Jiwei Deng
Rapid advances in functional electronics bring tremendous demands on innovation toward effective designs of device structures. Yarn supercapacitors (SCs) show advantages of flexibility, knittability, and small size, and can be integrated into various electronic devices with low cost and high efficiency for energy storage. In this work, functionalized stainless steel yarns are developed to support active materials of positive and negative electrodes, which not only enhance capacitance of both electrodes but can also be designed into stretchable configurations...
April 19, 2018: Small
Chi Zhang, Kieran Paddock, Adriana Chou, Austin Scholp, Ting Gong, Jack J Jiang
PURPOSE: Voice abuse is known to be a common risk factor of voice disorders and prolonged; high-intensity phonation has been shown to damage the vocal fold epithelium. We aim to evaluate the effects of phonation on the integrity and barrier function of vocal fold epithelium using a porcine laryngeal model. METHODS: Ex vivo porcine larynges were phonated at low intensity or high intensity for 15, 30, or 60 min within 4 h after harvest. Vocal fold epithelium was visualized using transmission electron microscopy (TEM)...
April 18, 2018: European Archives of Oto-rhino-laryngology
Dabin Liu, Chi Chun Wong, Li Fu, Huarong Chen, Liuyang Zhao, Chuangen Li, Yunfei Zhou, Yanquan Zhang, Weiqi Xu, Yidong Yang, Bin Wu, Gong Cheng, Paul Bo-San Lai, Nathalie Wong, Joseph J Y Sung, Jun Yu
Nonalcoholic fatty liver disease (NAFLD)-induced hepatocellular carcinoma (HCC) is an emerging malignancy in the developed world; however, mechanisms that contribute to its formation are largely unknown, and targeted therapy is currently not available. Our RNA sequencing analysis of NAFLD-HCC samples revealed squalene epoxidase ( SQLE ) as the top outlier metabolic gene overexpressed in NAFLD-HCC patients. Hepatocyte-specific Sqle transgenic expression in mice accelerated the development of high-fat, high-cholesterol diet-induced HCC...
April 18, 2018: Science Translational Medicine
Chi Zhang, Jiajia Wang, Adriana Chou, Ting Gong, Erin E Devine, Jack J Jiang
OBJECTIVES/HYPOTHESIS: Photodynamic therapy (PDT) is a promising treatment modality for laryngeal dysplasia, early-stage carcinoma, and papilloma, and was reported to have the ability to preserve laryngeal function and voice quality without clinical fibrotic response. We aimed to investigate the mechanism behind the antifibrotic effects of PDT on primary human vocal fold fibroblasts (VFFs) in vitro. STUDY DESIGN: In vitro analysis from one human donor. METHODS: Cell viability of VFFs in response to varying doses of PDT was investigated by the Cell Counting Kit-8 method...
April 18, 2018: Laryngoscope
Xiaoxiao Zhang, Tingyuan Gong, Hong Chi, Tianduo Li
Size control has been successfully achieved in inorganic materials, but it remains a challenge in polymer nanomaterials due to their polydispersity. Here, we report a facile approach to tailor the diameters of polyurethane (PU) nanoparticles (490 nm, 820 nm and 2.1 µm) via perylene bisimide (PBI) assisted self-assembly. The formed morphologies such as spindle, spherical and core-shell structures depend on the ratio of PBI and polymer concentrations. It is shown that the formation of PU nanoparticles is directed by π-π stacking of PBI and the morphology transition is not only affected by the amount of PBI incorporated, but also influenced by solvent, which controls the initial evaporation balance...
March 2018: Royal Society Open Science
Jing-Ying Yu, Ping Fang, Chi Wang, Xing-Xing Wang, Kun Li, Qian Gong, Ben-Yan Luo, Xiao-Dong Wang
Exposure to severely stressful experiences disrupts the activity of neuronal circuits and impairs declarative memory. GABAergic interneurons coordinate neuronal network activity, but their involvement in stress-evoked memory loss remains to be elucidated. Here, we provide evidence that interneurons in area CA1 of the dorsal hippocampus partially modulate acute stress-induced memory deficits. In adult male mice, both acute forced swim stress and restraint stress impaired hippocampus-dependent spatial memory and increased the density of c-fos-positive interneurons in the dorsal CA1...
April 4, 2018: Neuropharmacology
Zhang Peng, Du Hong-Bo, Tong Guang-Dong, Li Xiao-Ke, Sun Xue-Hua, Chi Xiao-Ling, Xing Yu-Feng, Zhou Zhen-Hua, Li Qin, Chen Bin, Wang Hui, Wang Li, Jin Hua, Mao De-Wen, Wang Xian-Bo, Wu Qi-Kai, Li Fen-Ping, Hu Xiao-Yu, Lu Bing-Jiu, Yang Zhi-Yun, Zhang Ming-Xiang, Shi Wei-Bing, He Qing, Li Yong, Jiang Kai-Ping, Xue Jing-Dong, Li Xiao-Dong, Jiang Jun-Min, Lu Wei, Tian Guang-Jun, Hu Zhen-Bin, Guo Jian-Chun, Li Cheng-Zhong, Deng Xin, Luo Xin-la, Li Feng-Yi, Zhang Xin-Wei, Zheng Ying-Jun, Zhao Gang, Wang Li-Chun, Wu Jian-Hua, Guo Hui, Mi Yu-Qiang, Gong Zuo-Jiong, Wang Cheng-Bao, Jiang Feng, Guo Peng, Yang Xian-Zhao, Shi Wei-Qun, Yang Hong-Zhi, Zhou Yong, Sun Ning-Ning, Jiao Yun-Tao, Gao Yue-Qiu, Zhou Da-Qiao, Ye Yong-An
The kinetics of serum hepatitis B surface antigen (HBsAg) during the natural history of hepatitis B virus (HBV) infection has been studied, but the factors affecting them remain unclear. AIMS: We aimed to investigate the factors affecting HBsAg titers, using data from multi-center, large-sized clinical trials in China. The baseline data of 1,795 patients in three multi-center trials were studied, and the patients were classified into three groups: hepatitis B early antigen (HBeAg)-positive chronic HBV infection (n=588), HBeAg-positive chronic hepatitis B (n=596), and HBeAg-negative chronic hepatitis B (n=611)...
April 6, 2018: Journal of Viral Hepatitis
Zaibao Zhang, Yilin Zhao, Xiaobing Feng, Zhaoyi Luo, Shuwei Kong, Chi Zhang, Andong Gong, Hongyu Yuan, Lin Cheng, Xiangnan Wang
Reactive oxygen species (ROS) are versatile signaling molecules in sensing stresses and play critical roles in signaling and development. Plasma membrane NADPH oxidases (NOXs) are key producers of ROS, and play important roles in the regulation of plant-pathogen interactions. Here, we performed a comprehensive analysis of the NOX gene family in the soybean genome (Glycine max) and 17 NOX (GmNOX) genes were identified. Structural analysis revealed that the GmNOX proteins in soybean were as conserved as those in other plants...
April 2, 2018: Genomics
Xin-Guang Liu, Xiao-Chuan Bai, Fang-Ping Chen, Yun-Feng Cheng, Ke-Sheng Dai, Mei-Yun Fang, Jian-Ming Feng, Yu-Ping Gong, Tao Guo, Xin-Hong Guo, Yue Han, Luo-Jia Hong, Yu Hu, Bao-Lai Hua, Rui-Bing Huang, Yan Li, Jun Peng, Mi-Mi Shu, Jing Sun, Pei-Yan Sun, Yu-Qian Sun, Chun-Sen Wang, Shu-Jie Wang, Xiao-Min Wang, Cong-Ming Wu, Wen-Man Wu, Zhen-Yu Yan, Feng-E Yang, Lin-Hua Yang, Ren-Chi Yang, Tong-Hua Yang, Xu Ye, Guang-Sen Zhang, Lei Zhang, Chang-Cheng Zheng, Hu Zhou, Min Zhou, Rong-Fu Zhou, Ze-Ping Zhou, Hong-Li Zhu, Tie-Nan Zhu, Ming Hou
Primary immune thrombocytopenia (ITP) is a bleeding disorder commonly encountered in clinical practice. The International Working Group (IWG) on ITP has published several landmark papers on terminology, definitions, outcome criteria, bleeding assessment, diagnosis, and management of ITP. The Chinese consensus reports for diagnosis and management of adult ITP have been updated to the 4th edition. Based on current consensus positions and new emerging clinical evidence, the thrombosis and hemostasis group of the Chinese Society of Hematology issued Chinese guidelines for management of adult ITP, which aim to provide evidence-based recommendations for clinical decision making...
April 4, 2018: International Journal of Hematology
Zheng Xiao, Chengqiong Wang, Rui Zhou, Shanshan Hu, Nian Yi, Jihong Feng, Minghua Zhou, Shiyu Liu, Ling Chen, Jie Ding, Qihai Gong, Fushan Tang, Xiaofei Li
OBJECTIVES: Aidi injection can significantly improve clinical response and reduce radiochemotherapy related toxicity. Can Aidi injection improve the survival in non-small-cell lung cancer (NSCLC)? Therefore, to further reveal it, we systematically evaluated all related studies. METHODS: We collected all studies about Aidi injection for NSCLC in Medline, Embase, Web of Science(ISI), China National Knowledge Infrastructure Database(CNKI), Chinese Scientific Journals Full-Text Database(VIP), Wanfang, China Biological Medicine Database (CBM), Cochrane Central Register of Controlled Trials (CENTRAL), Chinese clinical trial registry (Chi-CTR) and WHO International Clinical Trials Registry Platform (WHO-ICTRP), and US-clinical trials (established to June 2016)...
April 2018: Complementary Therapies in Medicine
Jinyu Zhou, Wei Nie, Yiqiang Chen, Chunjiang Yang, Lu Gong, Chi Zhang, Qian Chen, Lidong He, Xiaoyu Feng
In this study, we developed a quadruplex gold immunochromatogaraphic assay (GICA) for the simultaneous determination of four families of antibiotics including β-lactams, tetracyclines, streptomycin and chloramphenicol in milk. For qualitative analysis, the visual cut-off values were measured to be 2-100 ng/mL, 16-32 ng/mL, 50 ng/mL and 2.4 ng/mL for β-lactams, tetracyclines, streptomycin and chloramphenicol, respectively. For quantitative analysis, the detection ranges were 0.13-1 ng/mL for penicillin G, 0...
August 1, 2018: Food Chemistry
Sen Wu, Yaning Wang, Yue Ning, Hongfang Guo, Xiaoyu Wang, Le Zhang, Rajwali Khan, Gong Cheng, Hongbao Wang, Linsen Zan
Signal transducer and activator of transcription 3 (STAT3) plays a critical role in leptin-mediated regulation of energy metabolism. This study investigated genetic variation in STAT3 promoter regions and verified their contribution to bovine body size traits. We first estimated the degree of conservation in STAT3, followed by measurements of its mRNA expression during fetal and adult stages of Qinchuan cattle. We then sequenced the STAT3 promoter region to determine genetic variants and evaluate their association with body size traits...
March 29, 2018: International Journal of Molecular Sciences
Li-Juan Zheng, Jia-Chi Ma, Dong Fang, Li-Gang Wu, Zhen-Qiang Gong, Jian-Bo Qi, Xiao-Dan Zhao, Jian-Bo Du, Pei-Lan Ma
Background: This study aimed to analyze the stage-situation depression and anxiety as well as independent influential factors in patients with postsurgical gastroparesis syndrome (PGS) and to provide dependent indications for treatment. Patients and methods: The self-rating depression scale (SDS) and self-rating anxiety scale (SAS) were used to test the depression and anxiety of 53 patients with PGS, who were treated in the Department of Gastroenterological Surgery of Gansu Provincial Hospital from January 2012 to October 2016...
2018: Therapeutics and Clinical Risk Management
Peng Hu, Jia Shang, Wenhong Zhang, Guozhong Gong, Yongguo Li, Xinyue Chen, Jianning Jiang, Qing Xie, Xiaoguang Dou, Yongtao Sun, Yufang Li, Yingxia Liu, Guozhen Liu, Dewen Mao, Xiaoling Chi, Hong Tang, Xiaoou Li, Yao Xie, Xiaoping Chen, Jiaji Jiang, Ping Zhao, Jinlin Hou, Zhiliang Gao, Huimin Fan, Jiguang Ding, Dazhi Zhang, Hong Ren
Background and Aims: Hepatitis B surface antigen (HBsAg) loss is seldom achieved with nucleos(t)ide analog (NA) therapy in chronic hepatitis B patients but may be enhanced by switching to finite pegylated-interferon (Peg-IFN) alfa-2a. We assessed HBsAg loss with 48- and 96-week Peg-IFN alfa-2a in chronic hepatitis B patients with partial response to a previous NA. Methods: Hepatitis B e antigen (HBeAg)-positive patients who achieved HBeAg loss and hepatitis B virus DNA <200 IU/mL with previous adefovir, lamivudine or entecavir treatment were randomized 1:1 to receive Peg-IFN alfa-2a for 48 ( n = 153) or 96 weeks ( n = 150)...
March 28, 2018: Journal of Clinical and Translational Hepatology
Shao-Chi Wang, Yun Yang, Jing Liu, Ai-Dou Jiang, Zhao-Xing Chu, Si-Ying Chen, Guo-Qing Gong, Guang-Wei He, Yun-Gen Xu, Qi-Hua Zhu
Novel series of limonin derivatives (V-A-1-V-A-8, V-B-1-V-B-8) were synthesized by adding various tertiary amines onto the C (7)-position of limonin. The synthesized compounds possessed favorable physicochemical property, and the intrinsic solubility of the novel compounds were significantly improved, compared with limonin. Different pharmacological models were used to evaluate the analgesic and anti-inflammatory activities of the target compounds. Compound V-A-8 exhibited the strongest in vivo activity among the novel limonin analogs; its analgesic activity was more potent than aspirin and its anti-inflammatory activity was stronger than naproxen under our testing conditions...
March 2018: Chinese Journal of Natural Medicines
Gong Chen, Ya-Chi Chen, Bernhard Reis, Anton Belousov, Lori Jukofsky, Christine Rossin, Axel Muehlig, Chao Xu, Laurent Essioux, Toshihiko Ohtomo, Laura Di Laurenzio, Oscar Puig, Ray Lee
Background: Codrituzumab, a monoclonal antibody targeting an oncofetal protein glypican-3 (GPC3) expressed on cell surface of hepatocellular carcinoma (HCC) induces antibody-dependent cellular cytotoxicity (ADCC) and inhibits tumor growth in preclinical studies. Based on this mechanism, tumor GPC3 expression and CD16 expression on NK cells, which are the effector cells of ADCC, were investigated to correlate with codrituzumab's clinical efficacy in patients with advanced HCC. Results: Joint analyses of the two biomarkers revealed that both high levels of GPC3 and CD16 were required for patients to benefit from codrituzumab; lack of either one of them would lead to a loss of the therapeutic effect...
February 13, 2018: Oncotarget
Jianing Tang, Deguang Kong, Qiuxia Cui, Kun Wang, Dan Zhang, Xing Liao, Yan Gong, Gaosong Wu
BACKGROUND: The incidence of thyroid cancer in black Americans is significantly lower than that in white Americans, and the impact of race on the prognosis of thyroid cancer remains controversial. The purpose of this study was to determine the risk factors for survival in black and white patients and to compare the survival of differentiated thyroid carcinoma subtypes between these two races. We further investigated the association of lymph node and distant metastases with races. METHODS: This is a retrospective analysis using data from the National Cancer Institute's Surveillance, Epidemiology, and End Results Program...
March 5, 2018: World Journal of Surgical Oncology
Zhen-Lang Guo, Jun-Yue Wang, Lei-Liang Gong, Shu Gan, Chi-Ming Gu, Shu-Sheng Wang
BACKGROUND: We performed a meta-analysis to determine whether a consistent relationship exists between cadmium exposure and urolithiasis in humans. Accordingly, we summarized and reviewed previously published quantitative studies. METHODS: Eligible studies with reference lists published before June 1, 2017 were obtained from searching several databases. Random effects models were used to summary the overall estimate of the multivariate adjusted odds ratios (ORs) with 95% confidence intervals (CIs)...
January 2018: Medicine (Baltimore)
Baoshan Tang, Zhi Gen Yu, Li Huang, Jianwei Chai, Swee Liang Wong, Jie Deng, Weifeng Yang, Hao Gong, Shijie Wang, Kah-Wee Ang, Yong-Wei Zhang, Dongzhi Chi
Here we present a method for substitutional p-type doping in monolayer (1L) and few-layer (FL) WS2 using highly reactive nitrogen atoms. We demonstrate that the nitrogen-induced lattice distortion in atomically thin WS2 is negligible due to its low kinetic energy. The electrical characteristics of 1L/FL WS2 field-effect transistors (FETs) clearly show an n-channel to p-channel conversion with nitrogen incorporation. We investigate the defect formation energy and the origin of p-type conduction using first-principles calculations...
March 5, 2018: ACS Nano
P Dong, W Q Qiu, J F Shi, A Y Mao, H Y Huang, Z X Sun, J W Huang, X Z Liao, G X Liu, D B Wang, Y N Bai, X J Sun, J S Ren, L W Guo, L Lan, Y Q Liu, J Y Gong, L Yang, X J Xing, B B Song, Q Zhou, L Mai, L Zhu, L B Du, Y Z Zhang, J Y Zhou, M F Qin, S L Wu, X Qi, X H Sun, P A Lou, B Cai, K Zhang, J He, M Dai
Objective: To explore the sustainability of cancer screening strategy from potential demander's perspective in Chinese country, we conducted a study on the use of cancer screening services and willingness-to-pay among the urban community residents. All the participants of this study had not been on the Cancer Screening Program in Urban China (CanSPUC) or any other national level cancer screening projects. Methods: Target communities and populations were selected from the 16 project provinces in China which were on the program between 2014 and 2015, by using the multi-center cross-sectional convenience sampling method...
February 10, 2018: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
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