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https://www.readbyqxmd.com/read/29229205/cytotoxic-quinazoline-alkaloids-from-the-seeds-of-peganum-harmala
#1
Sheng-Ge Li, Kai-Bo Wang, Chi Gong, Yu Bao, Ning-Bo Qin, Da-Hong Li, Zhan-Lin Li, Jiao Bai, Hui-Ming Hua
Seventeen quinazoline alkaloids and derivatives, containing two pairs of new epimers, named as (S)- and (R)-1-(2-aminobenzyl)-3-hydroxypyrrolidin-2-one β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranoside (1, 2), (S)- and (R)-vasicinone β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranoside (3, 4), and a new enantiomer (12b), together with six known ones (5-8, 10, and 12a), and three pairs of known enantiomers (9, 11, and 13), were isolated from the ethanol extracts of the seeds of Peganum harmala L.. Their structures including the absolute configuration were elucidated by using 1D and 2D NMR, and ECD calculation approaches...
December 5, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29221703/four-new-compounds-from-the-roots-of-euphorbia-ebracteolata-and-their-inhibitory-effect-on-lps-induced-no-production
#2
Jiao Bai, Xue-Yan Huang, Zhi-Guo Liu, Chi Gong, Xin-Yu Li, Da-Hong Li, Hui-Ming Hua, Zhan-Lin Li
Three new diterpenoids, ebractenoids O~Q (1-3), and a new phenolic glucoside, γ-pyrone-3-O-β-d-(6-galloyl)-glucopyranoside (4), together with 6 known compounds, were isolated from the 95% ethanol extract of the roots of Euphorbia ebracteolata, and their structures were elucidated on the basis of spectroscopic data. The absolute configurations of 1-3 were determined by electronic circular dichroism (ECD) calculations. The inhibitory effects of all the isolates with exception of compounds 8 and 10 on the NO production in lipopolysaccharide (LPS)-induced macrophages were evaluated...
December 5, 2017: Fitoterapia
https://www.readbyqxmd.com/read/29211759/comparison-of-construct-validity-of-two-short-forms-of-stroke-specific-quality-of-life-scale
#3
Chia-Yeh Chou, Chien-Yu Huang, Yi-Jing Huang, Gong-Hong Lin, Sheau-Ling Huang, Shu-Chun Lee, Ching-Lin Hsieh
BACKGROUND: No studies have compared the 2-factor structures of Wong's and Post's versions of the short-form Stroke-Specific Quality of Life (i.e., 12-item SSQOL) scale. This study compared the construct validity of 2 short-forms of the 12-item-SSQOL (not the 12-domain-SSQOL). METHODS: Data were obtained from a previous validation study of the original 49-item SSQOL in 263 patients. Construct validity was tested by confirmatory factor analysis (CFA) to examine whether the two-factor structure, including psychosocial and physical domains, was supported in both versions...
2017: PloS One
https://www.readbyqxmd.com/read/29180355/photoreceptor-glucose-metabolism-determines-normal-retinal-vascular-growth
#4
Zhongjie Fu, Chatarina A Löfqvist, Raffael Liegl, Zhongxiao Wang, Ye Sun, Yan Gong, Chi-Hsiu Liu, Steven S Meng, Samuel B Burnim, Ivana Arellano, My T Chouinard, Rubi Duran, Alexander Poblete, Steve S Cho, James D Akula, Michael Kinter, David Ley, Ingrid Hansen Pupp, Saswata Talukdar, Ann Hellström, Lois Eh Smith
The neural cells and factors determining normal vascular growth are not well defined even though vision-threatening neovessel growth, a major cause of blindness in retinopathy of prematurity (ROP) (and diabetic retinopathy), is driven by delayed normal vascular growth. We here examined whether hyperglycemia and low adiponectin (APN) levels delayed normal retinal vascularization, driven primarily by dysregulated photoreceptor metabolism. In premature infants, low APN levels correlated with hyperglycemia and delayed retinal vascular formation...
November 27, 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/29180217/comparison-of-perioperative-complications-of-pedicled-island-flap-in-reconstruction-of-extremities
#5
Xu Gong, Jianli Cui, Ziping Jiang, Suraj Maharjan, Laijin Lu, Xiucun Li
PURPOSE: The aim of this study was to analyze the differences in perioperative complications for pedicled island flaps in the reconstruction of extremities and to identify the factors contributing to pedicled island flap necrosis. Furthermore, the flap indications based on these outcomes are summarized. METHODS: Based on the inclusion criteria, 228 skin flaps were included in this study. Univariate and multivariate analyses were used to identify the risk factors for pedicled island flap necrosis...
December 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/29133917/validation-of-self-reported-smoking-with-urinary-cotinine-levels-and-influence-of-second-hand-smoke-among-conscripts
#6
Yu-Lung Chiu, Shu-Jia Huang, Ching-Huang Lai, Chung-Chi Huang, Shiang-Huei Jiang, Shan-Ru Li, Shu-Ling Hwang, Fu-Gong Lin, Ya-Mei Tzeng, Senyeong Kao
Accurate identification of smoking behaviour is crucial to monitor the smoking rate. This study used urinary cotinine (UC) as a biomarker to verify the effectiveness of self-reported smoking behaviour among conscripts during recruit training. The influence of second-hand smoke (SHS) on the UC concentration was also analysed. A cross-sectional study was conducted from July 2014 to December 2014. The participants comprised a total of 621 military service and basic military training conscripts. A self-administered questionnaire survey and a urine test were performed to verify the participants' smoking behaviour...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29104623/microrna-155-regulates-the-proliferation-cell-cycle-apoptosis-and-migration-of-colon-cancer-cells-and-targets-cbl
#7
Hua Yu, Weiling Xu, Fangchao Gong, Baorong Chi, Junyi Chen, Ling Zhou
MicroRNA-155 (miR-155) is a well-studied miR and acts as an oncomiR in numerous cancer types. However, the biological functions of miR-155 in colon cancer as well as its target genes have remained to be fully elucidated. In order to investigate the biological functions of miR-155, MTT, colony formation and wound healing assays, cell cycle analysis and detection of apoptosis were performed. The results demonstrated that miR-155 promoted the proliferation of colon cancer cells and enhanced their colony formation capacity, promoted their cell cycle progression and inhibited apoptosis...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29102926/the-contribution-of-mmp-8-promoter-genotypes-to-childhood-leukemia
#8
Jen-Sheng Pei, Wen-Shin Chang, Pei-Chen Hsu, Yi-Wen Hung, Shun-Ping Cheng, Chia-Wen Tsai, DA-Tian Bau, Chi-Li Gong
BACKGROUND/AIM: Accumulated evidence has supported the notion that matrix metalloproteinase (MMP) genotypes are associated with the susceptibility of many types of cancers. However, few reports have studied the contribution of MMP genotypes to either diagnostic or prognostic potential in non-solid tumors such as leukemia. In this study, we firstly investigated the contribution of a polymorphism in the promoter region of MMP-8 (-799C/T) and two non-synonymous polymorphisms (Val436Ala and Lys460Thr) to childhood leukemia...
November 2017: In Vivo
https://www.readbyqxmd.com/read/29066914/upregulation-of-long-noncoding-rna-loc440040-promotes-tumor-progression-and-predicts-poor-prognosis-in-patients-with-prostate-cancer
#9
Cheng Zhang, Chunlin Liu, Jie Wu, Yuxiao Zheng, Haoxiang Xu, Gong Cheng, Lixin Hua
BACKGROUND/PURPOSE: Long noncoding RNAs (lncRNAs) play a functional role in the initiation and progression of prostate cancer (PCa). This study aimed to determine differentially expressed lncRNA through high-throughput sequencing technology and investigate its expression, biological function and clinical correlation with PCa. MATERIALS AND METHODS: Candidate lncRNAs were identified through microarray screening and bioanalysis. The expression of lncRNA LOC440040 in PCa tissues and cell lines was determined by reverse-transcription polymerase chain reaction...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29061145/effects-of-home-based-long-term-care-services-on-caregiver-health-according-to-age
#10
Ming-Chun Chen, Chi-Wen Kao, Yu-Lung Chiu, Tzu-Ying Lin, Yu-Ting Tsai, Yi-Ting Zhang Jian, Ya-Mei Tzeng, Fu-Gong Lin, Shu-Ling Hwang, Shan-Ru Li, Senyeong Kao
BACKGROUND: Caregiver health is a crucial public health concern due to the increasing number of elderly people with disabilities. Elderly caregivers are more likely to have poorer health and be a care recipient than younger caregivers. The Taiwan government offers home-based long-term care (LTC) services to provide formal care and decrease the burden of caregivers. This study examined the effects of home-based LTC services on caregiver health according to caregiver age. METHODS: This cross-sectional study included a simple random sample of care recipients and their caregivers...
October 23, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29056008/-clinical-effect-and-safety-of-pegylated-interferon-%C3%AE-2b-injection-y-shape-40-kd-in-treatment-of-hbeag-positive-chronic-hepatitis-b-patients
#11
F Q Hou, Y L Yin, L Y Zeng, J Shang, G Z Gong, C Pan, M X Zhang, C B Yin, Q Xie, Y Z Peng, S J Chen, Q Mao, Y P Chen, Q G Mao, D Z Zhang, T Han, M R Wang, W Zhao, J J Liu, Y Han, L F Zhao, G H Luo, J M Zhang, J Peng, D M Tan, Z W Li, H Tang, H Wang, Y X Zhang, J Li, L L Zhang, L Chen, J D Jia, C W Chen, Z Zhen, B S Li, J Q Niu, Q H Meng, H Yuan, Y T Sun, S C Li, J F Sheng, J Cheng, L Sun, G Q Wang
Objective: To investigate the clinical effect and safety of long-acting pegylated interferon-α-2b (Peg-IFN-α-2b) (Y shape, 40 kD) injection (180 μg/week) in the treatment of HBeAg-positive chronic hepatitis B (CHB) patients, with standard-dose Peg-IFN-α-2a as positive control. Methods: This study was a multicenter, randomized, open-label, and positive-controlled phase III clinical trial. Eligible HBeAg-positive CHB patients were screened out and randomized to Peg-IFN-α-2b (Y shape, 40 kD) trial group and Peg-IFN-α-2a control group at a ratio of 2:1...
August 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/29049179/genetic-polymorphisms-of-nat2-and-risk-of-acute-myeloid-leukemia-a-case-control-study
#12
Yunding Zou, Song Dong, Shuangnian Xu, Qiang Gong, Jieping Chen
Our purpose was to investigate the possible associations between N-acetyltransferase-2 (NAT2) gene polymorphisms and the risk of acute myeloid leukemia (AML) in Chinese Han population.A case-control study was conducted including 98 AML cases and 112 healthy controls. NAT2 gene 2 polymorphisms rs1799930 and rs1799931 were genotyped using direct sequencing. Chi-square test was performed to compare the genotype and allele distribution differences between groups. Odds ratio (OR) with 95% confidence interval (CI) was calculated to estimate the association between NAT2 gene polymorphisms and AML onset...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29041483/nanopatterned-luminescent-concentrators-for-visible-light-communications
#13
Yurong Dong, Meng Shi, Xilu Yang, Pan Zeng, Junyi Gong, Sunming Zheng, Mengjie Zhang, Rongqing Liang, Qiongrong Ou, Nan Chi, Shuyu Zhang
Visible light communication (VLC) is a promising candidate for high-speed wireless communication with numerous unlicensed spectrum. To achieve high-speed data communication, it requires intense light signals concentrated on a tiny fast photodiode. The common way of using focusing optics reduces the field of view (FoV) of the photodiode due to the conservation of étendue. Luminescent solar concentrators (LSC) provide a solution to enhance the signals without affecting the FoV. In this paper we demonstrate nanopatterned LSCs fabricated on flexible plastics that achieve a doubling of optical gain compared to its traditional rectangular counterparts...
September 4, 2017: Optics Express
https://www.readbyqxmd.com/read/29037809/prognostic-significance-of-high-yy1ap1-and-pcna-expression-in-colon-adenocarcinoma
#14
Yi-Jung Ho, Yueh-Min Lin, Yen-Chi Huang, Bingyang Shi, Kun-Tu Yeh, Zhiyuan Gong, Jeng-Wei Lu
To investigate the relationship between YY1AP1 and various clinicopathological features of colon adenocarcinoma (COAD), we conducted immunohistochemical (IHC) analyses of human tissue microarrays. We found that YY1AP1 protein expression was significantly higher in tumor tissue of the colon and liver, and was significantly lower in tumor tissue of the kidney. An analysis that employed the SurvExpress database indicated that increased expression of YY1AP1 mRNA was significantly associated with the overall survival of COAD patients...
October 15, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29031977/modeling-and-prediction-of-drug-dispersability-in-polyvinylpyrrolidone-vinyl-acetate-copolymer-using-a-molecular-descriptor
#15
Kevin DeBoyace, Ira S Buckner, Yuchuan Gong, Tzu-Chi Rob Ju, Peter L D Wildfong
The expansion of a novel in silico model for the prediction of the dispersability of 18 model compounds with polyvinylpyrrolidone-vinyl acetate copolymer (PVPva) is described. The molecular descriptor R3m (atomic mass weighted 3(rd) order autocorrelation index) is shown to be predictive of the formation of amorphous solid dispersions at two drug loadings (15% and 75% w/w) using two preparation methods (melt-quenching and solvent evaporation using a rotary evaporator). Co-solidified samples were characterized using a suite of analytical techniques, which included differential scanning calorimetry, powder X-ray diffraction, pair distribution function analysis, polarized light microscopy, and hot stage microscopy...
October 11, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29029491/bmi-and-serum-lipid-parameters-predict-increasing-risk-and-aggressive-prostate-cancer-in-chinese-people
#16
Ruizhe Zhao, Gong Cheng, Bing Wang, Chao Qin, Yun Liu, Yongsheng Pan, Jun Wang, Lixin Hua, Weidong Zhu, Zengjun Wang
OBJECTIVES: To determine if obesity and serum lipid parameters are associated with increased risk and more aggressive prostate cancer in Chinese population. MATERIALS AND METHODS: We conducted a retrospective cohort analysis including 3102 patients. Kruskal-Wallis test for continuous variables and the chi-squared tests for categorical variables were used for univariate comparison of the differences in patient characteristics across BMI categories between different groups...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28915274/prevalence-of-mind-and-body-exercises-mbe-in-relation-to-demographics-self-rated-health-and-purchases-of-prescribed-psychotropic-drugs-and-analgesics
#17
MULTICENTER STUDY
Lina Rådmark, Linda L Magnusson Hanson, Eva Bojner Horwitz, Walter Osika
This study aims to identify any differences regarding gender, age, socioeconomic status (SES), self-rated health, perceived stress and the purchase of prescribed drugs among people who practice mind and body exercises (MBE) extensively compared to people who do not. METHODS: The study includes 3,913 men and 4,803 women aged 20-72 who participated in the Swedish Longitudinal Occupational Survey of Health (SLOSH). The respondents were divided into three groups depending on frequency of MBE practice (never/seldom/often)...
2017: PloS One
https://www.readbyqxmd.com/read/28915257/outbreaks-of-epidemic-keratoconjunctivitis-caused-by-human-adenovirus-type-8-in-the-tibet-autonomous-region-of-china-in-2016
#18
Zhenqiang Lei, Zhen Zhu, Bai Ma Ci Wang, Hong Mei, Hong Li, Dan Zeng Gong Ga, Guo Jie, Mi Ma Bu Chi, Sheng Zhang, Chaofeng Ma, Wenbo Xu
From April to November 2016, two outbreaks of epidemic keratoconjunctivitis (EKC) occurred successively at primary and middle schools in the Tibet Autonomous Region of China, and a total of 197 clinically diagnosed cases were reported. Real-time PCR analyses confirmed that human adenovirus (HAdV) infection was related to these outbreaks. Further studies involving sequence determination and phylogenetic analysis based on the penton base, hexon, and fiber genes indicated that human adenovirus type 8 (HAdV-8), belonging to species D, was responsible for the outbreaks...
2017: PloS One
https://www.readbyqxmd.com/read/28913972/significance-of-histone-methyltransferase-setdb1-expression-in-colon-adenocarcinoma
#19
Yi-Jung Ho, Yueh-Min Lin, Yen-Chi Huang, Jungshan Chang, Kun-Tu Yeh, Liang-In Lin, Zhiyuan Gong, Tsai-Yu Tzeng, Jeng-Wei Lu
This study investigated the clinical implications of SETDB1 (also known as KMT1E) in human colon adenocarcinoma. Expression levels of SETDB1 proteins were analyzed by immunohistochemistry staining, and tissue microarrays were used to examine expression profiles in human patients. Our results revealed that SETDB1 protein expression was significantly higher in tumor tissue than in normal tissue for the breast, colon, liver, and lung (p < 0.05). Moreover, an analysis with SurvExpress software suggested that elevated expression of SETDB1 mRNA was significantly associated with the overall survival of colon adenocarcinoma patients (p < 0...
November 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28887321/lncrna-pagbc-acts-as-a-microrna-sponge-and-promotes-gallbladder-tumorigenesis
#20
Xiang-Song Wu, Fang Wang, Huai-Feng Li, Yun-Ping Hu, Lin Jiang, Fei Zhang, Mao-Lan Li, Xu-An Wang, Yun-Peng Jin, Yi-Jian Zhang, Wei Lu, Wen-Guang Wu, Yi-Jun Shu, Hao Weng, Yang Cao, Run-Fa Bao, Hai-Bin Liang, Zheng Wang, Yi-Chi Zhang, Wei Gong, Lei Zheng, Shu-Han Sun, Ying-Bin Liu
Long noncoding RNAs (lncRNAs) play roles in the development and progression of many cancers; however, the contributions of lncRNAs to human gallbladder cancer (GBC) remain largely unknown. In this study, we identify a group of differentially expressed lncRNAs in human GBC tissues, including prognosis-associated gallbladder cancer lncRNA (lncRNA-PAGBC), which we find to be an independent prognostic marker in GBC Functional analysis indicates that lncRNA-PAGBC promotes tumour growth and metastasis of GBC cells...
October 2017: EMBO Reports
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