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https://www.readbyqxmd.com/read/29923713/controllable-supramolecular-chiral-twisted-nanoribbons-from-achiral-conjugated-oligoaniline-derivatives
#1
Chuanqiang Zhou, Yuanyuan Ren, Jie Han, Xiangxiang Gong, Zhixiang Wei, Ju Xie, Rong Guo
The fabrication of supramolecular chiral nanostructures from achiral materials without the need of pre-existing chirality is a major chal-lenge associated with the origin of life. Herein, supramolecular chiral twisted nanoribbons of achiral oligoaniline derivatives were prepared via simply performing the chemical oxidation of aniline in alcohol/water mixed solvent. In particular, the supramolecular chi-rality of the twisted nanoribbons could be controlled by facilely tuning the alcohol content in the mixed solvent...
June 20, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29909312/icariin-loaded-electrospun-pcl-gelatin-nanofiber-membrane-as-potential-artificial-periosteum
#2
Min Gong, Cheng Chi, Jingjing Ye, Meihong Liao, Wenqi Xie, Chengai Wu, Rui Shi, Liqun Zhang
Due to the significant role of the periosteum in bone regeneration, we hypothesised that using a specially engineered artificial periosteum could lead to an enhancement in osteogenesis in bone grafts. Herein, we describe our work aimed at fabricating an electrospun fibrous membrane as an artificial periosteum that exhibits flexibility, permeability and osteoinduction. This membrane was designed to cover the complex surface of bone grafts to facilitate and accelerate bone regeneration. The traditional Chinese medicine icariin (ICA) was subsequently introduced into poly (ε-caprolactone) (PCL) /gelatin nanofibers to fabricate an artificial periosteum for the first time...
June 14, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29851539/synthesis-characterization-and-in-vitro-evaluation-of-trail-modified-cabazitaxel-loaded-polymeric-micelles-for-achieving-synergistic-anticancer-therapy
#3
Caochuan Feng, Xiaoxiong Han, Lili Chi, Jing Sun, Feirong Gong, Yaling Shen
Combination therapy of two or more drugs has gradually become of outmost importance in cancer treatment. Cabazitaxel (CTX) is a taxoid drug and tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of TNF superfamily. In this study, we prepared TRAIL-modified and CTX-loaded polymer micelle (TRAIL-M-CTX). This nanoparticle was self-assembled from biodegradable amphiphilic copolymers, monomethoxyl poly(ethylene glycol)-b-poly(DL-lactide) (mPEG-PLA) and COOH-PEG-PLA, via a nanoprecipitation method and were modified with the TRAIL protein, resulting in a particle size of 39...
May 31, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29792233/antibiotic-resistance-and-molecular-characterization-of-diarrheagenic-escherichia-coli-and-non-typhoidal-salmonella-strains-isolated-from-infections-in-southwest-china
#4
Shun-Xian Zhang, Yong-Ming Zhou, Li-Guang Tian, Jia-Xu Chen, Rita Tinoco-Torres, Emmanuel Serrano, Shi-Zhu Li, Shao-Hong Chen, Lin Ai, Jun-Hu Chen, Shang Xia, Yan Lu, Shan Lv, Xue-Jiao Teng, Wen Xu, Wen-Peng Gu, Si-Tang Gong, Xiao-Nong Zhou, Lan-Lan Geng, Wei Hu
BACKGROUND: Bacterial diarrhea is one of the most common causes for medical consultations, mortality and morbidity in the world. Diarrheagenic Escherichia coli (DEC) and non-typhoidal Salmonella (NTS) are major intestinal pathogens in developing countries, and the indiscriminate use of antibiotics has greatly contributed to resistant strains. Hence, the aim of the present study is to identify the antimicrobial resistance patterns and the molecular characteristics of DEC and NTS in southwest, China...
May 7, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29788728/clinical-characteristics-and-treatments-of-patients-with-alpha-fetoprotein-producing-gastric-carcinoma
#5
W Gong, Y Su, A Liu, J Liu, D Sun, T Jiang, J Xiang, C Chi, P Sun
Alpha-fetoprotein (AFP) is a well-known tumor marker of hepatic carcinoma and yolk sac tumor. Alpha-fetoprotein producing gastric carcinoma (AFPGC) is a rare type of gastric cancer with high malignancy and poor prognosis, which make it different from other types of gastric cancer. This rare gastric cancer patient subgroup is likely frequently misdiagnosed which may be related to lack of knowledge of the disease. The purpose of this article is to summarize the mechanism of AFP positive gastric cancer, classification, biological behavior and treatment, in order to assist clinical practitioners to detect AFPGC earlier and treat it better...
March 14, 2018: Neoplasma
https://www.readbyqxmd.com/read/29736553/effects-of-tai-chi-on-balance-and-gait-in-stroke-survivors-a-systematic-meta-analysis-of-randomized-controlled-trials
#6
Gai Yan Li, Wei Wang, Gong Liang Liu, Ying Zhang
OBJECTIVE: To investigate the effects of tai chi on balance and gait in stroke survivors. METHODS: A systematic meta-analysis of randomized controlled trials on the effects of tai chi on balance and gait in stroke survivors. RESULTS: Five randomized controlled trials, with a total of 346 patients, were included in the meta-analysis. All of these studies had a high bias based on the Cochrane Collaboration recommendation, and a relatively small sample size...
May 8, 2018: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29675877/design-of-novel-wearable-stretchable-and-waterproof-cable-type-supercapacitors-based-on-high-performance-nickel-cobalt-sulfide-coated-etching-annealed-yarn-electrodes
#7
Yuejiao Chen, Bingang Xu, Jianfeng Wen, Jianliang Gong, Tao Hua, Chi-Wai Kan, Jiwei Deng
Rapid advances in functional electronics bring tremendous demands on innovation toward effective designs of device structures. Yarn supercapacitors (SCs) show advantages of flexibility, knittability, and small size, and can be integrated into various electronic devices with low cost and high efficiency for energy storage. In this work, functionalized stainless steel yarns are developed to support active materials of positive and negative electrodes, which not only enhance capacitance of both electrodes but can also be designed into stretchable configurations...
May 2018: Small
https://www.readbyqxmd.com/read/29671091/prolonged-phonation-impairs-the-integrity-and-barrier-function-of-porcine-vocal-fold-epithelium-a-preliminary-study
#8
Chi Zhang, Kieran Paddock, Adriana Chou, Austin Scholp, Ting Gong, Jack J Jiang
PURPOSE: Voice abuse is known to be a common risk factor of voice disorders and prolonged; high-intensity phonation has been shown to damage the vocal fold epithelium. We aim to evaluate the effects of phonation on the integrity and barrier function of vocal fold epithelium using a porcine laryngeal model. METHODS: Ex vivo porcine larynges were phonated at low intensity or high intensity for 15, 30, or 60 min within 4 h after harvest. Vocal fold epithelium was visualized using transmission electron microscopy (TEM)...
June 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29669855/squalene-epoxidase-drives-nafld-induced-hepatocellular-carcinoma-and-is-a-pharmaceutical-target
#9
Dabin Liu, Chi Chun Wong, Li Fu, Huarong Chen, Liuyang Zhao, Chuangen Li, Yunfei Zhou, Yanquan Zhang, Weiqi Xu, Yidong Yang, Bin Wu, Gong Cheng, Paul Bo-San Lai, Nathalie Wong, Joseph J Y Sung, Jun Yu
Nonalcoholic fatty liver disease (NAFLD)-induced hepatocellular carcinoma (HCC) is an emerging malignancy in the developed world; however, mechanisms that contribute to its formation are largely unknown, and targeted therapy is currently not available. Our RNA sequencing analysis of NAFLD-HCC samples revealed squalene epoxidase ( SQLE ) as the top outlier metabolic gene overexpressed in NAFLD-HCC patients. Hepatocyte-specific Sqle transgenic expression in mice accelerated the development of high-fat, high-cholesterol diet-induced HCC...
April 18, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29668038/photodynamic-therapy-induces-antifibrotic-alterations-in-primary-human-vocal-fold-fibroblasts
#10
Chi Zhang, Jiajia Wang, Adriana Chou, Ting Gong, Erin E Devine, Jack J Jiang
OBJECTIVES/HYPOTHESIS: Photodynamic therapy (PDT) is a promising treatment modality for laryngeal dysplasia, early-stage carcinoma, and papilloma, and was reported to have the ability to preserve laryngeal function and voice quality without clinical fibrotic response. We aimed to investigate the mechanism behind the antifibrotic effects of PDT on primary human vocal fold fibroblasts (VFFs) in vitro. STUDY DESIGN: In vitro analysis from one human donor. METHODS: Cell viability of VFFs in response to varying doses of PDT was investigated by the Cell Counting Kit-8 method...
April 18, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29657775/nanostructured-polyurethane-perylene-bisimide-ester-assemblies-with-tuneable-morphology-and-enhanced-stability
#11
Xiaoxiao Zhang, Tingyuan Gong, Hong Chi, Tianduo Li
Size control has been successfully achieved in inorganic materials, but it remains a challenge in polymer nanomaterials due to their polydispersity. Here, we report a facile approach to tailor the diameters of polyurethane (PU) nanoparticles (490 nm, 820 nm and 2.1 µm) via perylene bisimide (PBI) assisted self-assembly. The formed morphologies such as spindle, spherical and core-shell structures depend on the ratio of PBI and polymer concentrations. It is shown that the formation of PU nanoparticles is directed by π-π stacking of PBI and the morphology transition is not only affected by the amount of PBI incorporated, but also influenced by solvent, which controls the initial evaporation balance...
March 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29626564/dorsal-ca1-interneurons-contribute-to-acute-stress-induced-spatial-memory-deficits
#12
Jing-Ying Yu, Ping Fang, Chi Wang, Xing-Xing Wang, Kun Li, Qian Gong, Ben-Yan Luo, Xiao-Dong Wang
Exposure to severely stressful experiences disrupts the activity of neuronal circuits and impairs declarative memory. GABAergic interneurons coordinate neuronal network activity, but their involvement in stress-evoked memory loss remains to be elucidated. Here, we provide evidence that interneurons in area CA1 of the dorsal hippocampus partially modulate acute stress-induced memory deficits. In adult male mice, both acute forced swim stress and restraint stress impaired hippocampus-dependent spatial memory and increased the density of c-fos-positive interneurons in the dorsal CA1...
June 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29624802/serum-hepatitis-b-surface-antigen-correlates-with-fibrosis-and-necroinflammation-a-multicentre-perspective-in-china
#13
P Zhang, H B Du, G D Tong, X K Li, X H Sun, X L Chi, Y F Xing, Z H Zhou, Q Li, B Chen, H Wang, L Wang, H Jin, D W Mao, X B Wang, Q K Wu, F P Li, X Y Hu, B J Lu, Z Y Yang, M X Zhang, W B Shi, Q He, Y Li, K P Jiang, J D Xue, X D Li, J M Jiang, W Lu, G J Tian, Z B Hu, J C Guo, C Z Li, X Deng, X L Luo, F Y Li, X W Zhang, Y J Zheng, G Zhao, L C Wang, J H Wu, H Guo, Y Q Mi, Z J Gong, C B Wang, F Jiang, P Guo, X Z Yang, W Q Shi, H Z Yang, Y Zhou, N N Sun, Y T Jiao, Y Q Gao, D Q Zhou, Y A Ye
The kinetics of serum hepatitis B surface antigen (HBsAg) during the natural history of hepatitis B virus (HBV) infection has been studied, but the factors affecting them remain unclear. We aimed to investigate the factors affecting HBsAg titres, using data from multicentre, large-sized clinical trials in China. The baseline data of 1795 patients in 3 multicentre trials were studied, and the patients were classified into 3 groups: hepatitis B early antigen (HBeAg)-positive chronic HBV infection (n = 588), HBeAg-positive chronic hepatitis B (n = 596), and HBeAg-negative chronic hepatitis B (n = 611)...
April 6, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29621573/genomic-molecular-evolution-and-expression-analysis-of-nox-genes-in-soybean-glycine-max
#14
Zaibao Zhang, Yilin Zhao, Xiaobing Feng, Zhaoyi Luo, Shuwei Kong, Chi Zhang, Andong Gong, Hongyu Yuan, Lin Cheng, Xiangnan Wang
Reactive oxygen species (ROS) are versatile signaling molecules in sensing stresses and play critical roles in signaling and development. Plasma membrane NADPH oxidases (NOXs) are key producers of ROS, and play important roles in the regulation of plant-pathogen interactions. Here, we performed a comprehensive analysis of the NOX gene family in the soybean genome (Glycine max) and 17 NOX (GmNOX) genes were identified. Structural analysis revealed that the GmNOX proteins in soybean were as conserved as those in other plants...
April 3, 2018: Genomics
https://www.readbyqxmd.com/read/29619624/chinese-guidelines-for-treatment-of-adult-primary-immune-thrombocytopenia
#15
Xin-Guang Liu, Xiao-Chuan Bai, Fang-Ping Chen, Yun-Feng Cheng, Ke-Sheng Dai, Mei-Yun Fang, Jian-Ming Feng, Yu-Ping Gong, Tao Guo, Xin-Hong Guo, Yue Han, Luo-Jia Hong, Yu Hu, Bao-Lai Hua, Rui-Bing Huang, Yan Li, Jun Peng, Mi-Mi Shu, Jing Sun, Pei-Yan Sun, Yu-Qian Sun, Chun-Sen Wang, Shu-Jie Wang, Xiao-Min Wang, Cong-Ming Wu, Wen-Man Wu, Zhen-Yu Yan, Feng-E Yang, Lin-Hua Yang, Ren-Chi Yang, Tong-Hua Yang, Xu Ye, Guang-Sen Zhang, Lei Zhang, Chang-Cheng Zheng, Hu Zhou, Min Zhou, Rong-Fu Zhou, Ze-Ping Zhou, Hong-Li Zhu, Tie-Nan Zhu, Ming Hou
Primary immune thrombocytopenia (ITP) is a bleeding disorder commonly encountered in clinical practice. The International Working Group (IWG) on ITP has published several landmark papers on terminology, definitions, outcome criteria, bleeding assessment, diagnosis, and management of ITP. The Chinese consensus reports for diagnosis and management of adult ITP have been updated to the 4th edition. Based on current consensus positions and new emerging clinical evidence, the thrombosis and hemostasis group of the Chinese Society of Hematology issued Chinese guidelines for management of adult ITP, which aim to provide evidence-based recommendations for clinical decision making...
June 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29609937/can-aidi-injection-improve-overall-survival-in-patients-with-non-small-cell-lung-cancer-a-systematic-review-and-meta-analysis-of-25-randomized-controlled-trials
#16
REVIEW
Zheng Xiao, Chengqiong Wang, Rui Zhou, Shanshan Hu, Nian Yi, Jihong Feng, Minghua Zhou, Shiyu Liu, Ling Chen, Jie Ding, Qihai Gong, Fushan Tang, Xiaofei Li
OBJECTIVES: Aidi injection can significantly improve clinical response and reduce radiochemotherapy related toxicity. Can Aidi injection improve the survival in non-small-cell lung cancer (NSCLC)? Therefore, to further reveal it, we systematically evaluated all related studies. METHODS: We collected all studies about Aidi injection for NSCLC in Medline, Embase, Web of Science(ISI), China National Knowledge Infrastructure Database(CNKI), Chinese Scientific Journals Full-Text Database(VIP), Wanfang, China Biological Medicine Database (CBM), Cochrane Central Register of Controlled Trials (CENTRAL), Chinese clinical trial registry (Chi-CTR) and WHO International Clinical Trials Registry Platform (WHO-ICTRP), and US-clinical trials (established to June 2016)...
April 2018: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/29606452/quadruplex-gold-immunochromatogaraphic-assay-for-four-families-of-antibiotic-residues-in-milk
#17
Jinyu Zhou, Wei Nie, Yiqiang Chen, Chunjiang Yang, Lu Gong, Chi Zhang, Qian Chen, Lidong He, Xiaoyu Feng
In this study, we developed a quadruplex gold immunochromatogaraphic assay (GICA) for the simultaneous determination of four families of antibiotics including β-lactams, tetracyclines, streptomycin and chloramphenicol in milk. For qualitative analysis, the visual cut-off values were measured to be 2-100 ng/mL, 16-32 ng/mL, 50 ng/mL and 2.4 ng/mL for β-lactams, tetracyclines, streptomycin and chloramphenicol, respectively. For quantitative analysis, the detection ranges were 0.13-1 ng/mL for penicillin G, 0...
August 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29596388/genetic-variants-in-stat3-promoter-regions-and-their-application-in-molecular-breeding-for-body-size-traits-in-qinchuan-cattle
#18
Sen Wu, Yaning Wang, Yue Ning, Hongfang Guo, Xiaoyu Wang, Le Zhang, Rajwali Khan, Gong Cheng, Hongbao Wang, Linsen Zan
Signal transducer and activator of transcription 3 (STAT3) plays a critical role in leptin-mediated regulation of energy metabolism. This study investigated genetic variation in STAT3 promoter regions and verified their contribution to bovine body size traits. We first estimated the degree of conservation in STAT3, followed by measurements of its mRNA expression during fetal and adult stages of Qinchuan cattle. We then sequenced the STAT3 promoter region to determine genetic variants and evaluate their association with body size traits...
March 29, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29588594/the-quantification-and-assessment-of-depression-and-anxiety-in-patients-with-postoperative-gastroparesis-syndrome
#19
Li-Juan Zheng, Jia-Chi Ma, Dong Fang, Li-Gang Wu, Zhen-Qiang Gong, Jian-Bo Qi, Xiao-Dan Zhao, Jian-Bo Du, Pei-Lan Ma
Background: This study aimed to analyze the stage-situation depression and anxiety as well as independent influential factors in patients with postsurgical gastroparesis syndrome (PGS) and to provide dependent indications for treatment. Patients and methods: The self-rating depression scale (SDS) and self-rating anxiety scale (SAS) were used to test the depression and anxiety of 53 patients with PGS, who were treated in the Department of Gastroenterological Surgery of Gansu Provincial Hospital from January 2012 to October 2016...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29577029/hbsag-loss-with-peg-interferon-alfa-2a-in-hepatitis-b-patients-with-partial-response-to-nucleos-t-ide-analog-new-switch-study
#20
Peng Hu, Jia Shang, Wenhong Zhang, Guozhong Gong, Yongguo Li, Xinyue Chen, Jianning Jiang, Qing Xie, Xiaoguang Dou, Yongtao Sun, Yufang Li, Yingxia Liu, Guozhen Liu, Dewen Mao, Xiaoling Chi, Hong Tang, Xiaoou Li, Yao Xie, Xiaoping Chen, Jiaji Jiang, Ping Zhao, Jinlin Hou, Zhiliang Gao, Huimin Fan, Jiguang Ding, Dazhi Zhang, Hong Ren
Background and Aims: Hepatitis B surface antigen (HBsAg) loss is seldom achieved with nucleos(t)ide analog (NA) therapy in chronic hepatitis B patients but may be enhanced by switching to finite pegylated-interferon (Peg-IFN) alfa-2a. We assessed HBsAg loss with 48- and 96-week Peg-IFN alfa-2a in chronic hepatitis B patients with partial response to a previous NA. Methods: Hepatitis B e antigen (HBeAg)-positive patients who achieved HBeAg loss and hepatitis B virus DNA <200 IU/mL with previous adefovir, lamivudine or entecavir treatment were randomized 1:1 to receive Peg-IFN alfa-2a for 48 ( n = 153) or 96 weeks ( n = 150)...
March 28, 2018: Journal of Clinical and Translational Hepatology
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