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https://www.readbyqxmd.com/read/29656047/the-complex-association-between-metabolic-syndrome-and-male-hypogonadism
#1
Christina Dimopoulou, Dimitrios G Goulis, Giovanni Corona, Mario Maggi
BACKGROUND: The complex association between metabolic syndrome (MetS) and male hypogonadism is well established. A number of observational studies show that low testosterone is associated with insulin resistance and an increased risk for diabetes mellitus and MetS in men. AIMS: To elucidate the association between MetS and male hypogonadism, present epidemiological data on the co-existence of the two comorbidities, enlighten the underlying pathophysiology and appraise the effects of testosterone supplementation therapy (TTh) and lifestyle modifications on MetS and body composition in men...
April 12, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29655793/inhibition-of-nlrp9b-attenuates-acute-lung-injury-through-suppressing-inflammation-apoptosis-and-oxidative-stress-in-murine-and-cell-models
#2
Qiu Yanling, Cheng Xiaoning, Bai Fei, Fang Liyun, Hu Huizhong, Sun Daqing
Acute lung injury (ALI), known a severe disease along with high morbidity and mortality, is lacking of specific therapies. Inflammation, apoptosis and oxidative stress are critical pathologies that contribute to ALI. Recently, there is study indicated that NLRP9b, a NOD-like receptor (NLR) member, is critical in modulation of inflammatory response. However, the effects of NLRP9b on sepsis-associated ALI, and the underlying molecular mechanism have not been understood. In the present study, the wild type (WT) and NLRP9b-knockout (NLRP9b-/- ) mice with C57B/L6 background were subjected to a cecal ligation and puncture (CLP) for ALI murine model establishment...
April 12, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29655702/4-2-4-chlorophenyl-1-4-chlorophenyl-amino-ethyl-benzene-1-3-diol-is-a-potential-agent-for-gout-therapy-as-a-dual-inhibitor-of-xod-and-nlrp3
#3
Mengze Zhou, Suning Li, Ling Song, Qinghua Hu, Wentao Liu
BACKGOUND: Gout is an inflammatory arthritis characterized by abrupt self-limiting attacks of inflammation caused by precipitation of monosodium urate crystals (MSU) in the joint. Both anti-hyperuricemia and anti-inflammation could be gout therapeutic strategies, whereas ideal drugs for gout treatment are deficient. PURPOSE: 4-(2-(4-chlorophenyl)-1-((4-chlorophenyl)amino)ethyl)benzene-1, 3-diol (CBED) was obtained from a cluster of deoxybenzoins derivatives synthesized by our research group with potent anti-hyperuricemic and anti-inflammatory activities, which was expected to be a dual inhibitor of xanthine oxidase (XOD) and NOD-like receptor protein 3 (NLRP3)...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29655563/laboratory-evaluation-of-a-novel-rapid-tube-test-system-for-differentiation-of-mastitis-causing-pathogen-groups
#4
S Leimbach, V Krömker
Because clinical mastitis, one of the most common diseases in dairy cows, is routinely treated with antimicrobial substances, it offers a high potential for future reduction of antimicrobial usage. In fact, intramammary antibiotic administration is not advisable in cases of clinical mastitis caused by coliform bacteria, yeasts, or protothecae or in cases with no detectable mastitis pathogen. To avoid unnecessary treatments with antimicrobials for the benefit of animal health and public welfare, the rapid identification of the mastitis-causing pathogens becomes necessary...
April 11, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29655480/nontraditional-therapies-traditional-chinese-veterinary-medicine-and-chiropractic-in-exotic-animals
#5
REVIEW
Jessica A Marziani
The nontraditional therapies of Traditional Chinese Veterinary Medicine and chiropractic care are adjunct treatments that can be used in conjunction with more conventional therapies to treat a variety of medical conditions. Nontraditional therapies do not need to be alternatives to Western medicine but, instead, can be used simultaneously. Exotic animal practitioners should have a basic understanding of nontraditional therapies for both client education and patient referral because they can enhance the quality of life, longevity, and positive outcomes for various cases across multiple taxa...
May 2018: Veterinary Clinics of North America. Exotic Animal Practice
https://www.readbyqxmd.com/read/29655474/prudent-use-of-antimicrobials-in-exotic-animal-medicine
#6
REVIEW
Els M Broens, Ingeborg M van Geijlswijk
Reduction of antimicrobial use can result in reduction of resistance in commensal bacteria. In exotic animals, information on use of antimicrobials and resistance in commensals and pathogens is scarce. However, use of antimicrobials listed as critically important antimicrobials for human medicine seems high in exotic animals. Ideally, the selection of a therapy should be based on an accurate diagnosis and antimicrobial susceptibility testing. When prescribing antimicrobials based on empiricism, knowledge of the most common pathogens causing specific infections and the antimicrobial spectrum of antimicrobial agents is indispensable...
May 2018: Veterinary Clinics of North America. Exotic Animal Practice
https://www.readbyqxmd.com/read/29653287/detecting-the-functional-complexities-between-high-density-lipoprotein-mimetics
#7
Yoshitaka J Sei, Jungho Ahn, Taeyoung Kim, Eunjung Shin, Angel J Santiago-Lopez, Seung Soon Jang, Noo Li Jeon, Young C Jang, YongTae Kim
High-density lipoprotein (HDL) is a key regulator of lipid homeostasis through its native roles like reverse cholesterol transport. The reconstitution of this natural nanoparticle (NP) has become a nexus between nanomedicine and multi-disease therapies, for which a major portion of HDL functionality is attributed to its primary scaffolding protein, apolipoprotein A1 (apoA1). ApoA1-mimetic peptides were formulated as cost-effective alternatives to apoA1-based therapies; reverse-4F (r4F) is one such peptide used as part of a nanoparticle platform...
April 6, 2018: Biomaterials
https://www.readbyqxmd.com/read/29653222/gemcitabine-loaded-microbubbles-for-targeted-chemo-sonodynamic-therapy-of-pancreatic-cancer
#8
Heather Nesbitt, Yingjie Sheng, Sukanta Kamila, Keiran Logan, Keith Thomas, Bridgeen Callan, Mark A Taylor, Mark Love, Declan O'Rourke, Paul Kelly, Estelle Beguin, Eleanor Stride, Anthony P McHale, John F Callan
Pancreatic cancer remains one of the most lethal forms of cancer with a 10-year survival of <1%. With little improvement in survival rates observed in the past 40 years, there is a significant need for new treatments or more effective strategies to deliver existing treatments. The antimetabolite gemcitabine (Gem) is the most widely used form of chemotherapy for pancreatic cancer treatment, but is known to produce significant side effects when administered systemically. We have previously demonstrated the benefit of combined chemo-sonodynamic therapy (SDT), delivered using oxygen carrying microbubbles (O2 MB), as a targeted treatment for pancreatic cancer in a murine model of the disease...
April 10, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29653183/atropa-belladonna-neurotoxicity-implications-to-neurological-disorders
#9
REVIEW
Gunnar F Kwakye, Jennifer Jiménez, Jessica A Jiménez, Michael Aschner
Atropa belladonna, commonly known as belladonna or deadly nightshade, ranks among one of the most poisonous plants in Europe and other parts of the world. The plant contains tropane alkaloids, including atropine, scopolamine, and hyoscyamine, which are used as anticholinergics in Food and Drug Administration (FDA) approved drugs and homeopathic remedies. These alkaloids can be very toxic at high dose. The FDA has recently reported that Hyland's baby teething tablets contain inconsistent amounts of Atropa belladonna that may have adverse effects on the nervous system and cause death in children, thus recalled the product in 2017...
April 10, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29652901/early-postnatal-soluble-fgfr3-therapy-prevents-the-atypical-development-of-obesity-in-achondroplasia
#10
Celine Saint-Laurent, Stephanie Garcia, Vincent Sarrazy, Karine Dumas, Florence Authier, Sophie Sore, Albert Tran, Philippe Gual, Isabelle Gennero, Jean-Pierre Salles, Elvire Gouze
BACKGROUND: Achondroplasia is a rare genetic disease is characterized by abnormal bone development and early obesity. While the bone aspect of the disease has been thoroughly studied, early obesity affecting approximately 50% of them during childhood has been somewhat neglected. It nevertheless represents a major health problem in these patients, and is associated to life-threatening complications including increasing risk of cardiovascular pathologies. We have thus decided to study obesity in patients and to use the mouse model to evaluate if soluble FGFR3 therapy, an innovative treatment approach for achondroplasia, could also impact the development of this significant complication...
2018: PloS One
https://www.readbyqxmd.com/read/29652059/targeted-delivery-of-tungsten-oxide-nanoparticles-for-multifunctional-anti-tumor-therapy-via-macrophages
#11
Bin Zheng, Yang Bai, Hongbin Chen, Huizhuo Pan, Wanying Ji, Xiaoqun Gong, Xiaoli Wu, Hanjie Wang, Jin Chang
Tumor-associated macrophages are highly versatile effector cells that have been used to kill tumor cells. Herein, the macrophages as cell-based biocarriers are used for the targeted delivery of photothermal reagents for promoting the efficiency of killing tumor cells by activating the anti-tumor immune response and photothermal therapy (PTT). In this design, macrophages cause the phagocytosis of tumor cells and activate the anti-tumor immune response by secreting plenty of cytokines. Meanwhile, to improve the tumor-killing effect and track the collaborative therapy system in vivo, a novel nanoplatform based on tungsten oxide (W18O49, WO) nanoparticles and fluorescent dyes loaded in polylactic-co-glycolic acid (PLGA) for PTT has been successfully constructed...
April 13, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29651925/heptamer-peptide-disassembles-native-amyloid-in-human-plasma-via-heat-shock-protein-70
#12
Timothy James Cunningham, Jeffrey I Greenstein, Lihua Yao, Itzhak Fischer, Theresa Conners
Proteostasis, which includes the repair and disposal of misfolded proteins, depends in part on the activity of heat shock proteins, a well-known class of chaperone molecules. When this process fails abnormally folded proteins may accumulate in cells, tissues, and blood. These species are a hallmark of protein aggregation diseases but also amass during aging, often in the absence of an identified clinical disorder. We report that a neuroprotective cyclic heptapeptide, CHEC-7, which has been applied systemically as a therapeutic in animal neurodegeneration models, disrupts such aggregates and inhibits amyloidogenesis when added in nanomolar concentrations to human plasma...
April 13, 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29651825/feasibility-of-using-optical-coherence-tomography-to-detect-acute-radiation-induced-esophageal-damage-in-small-animal-models
#13
Pouya Jelvehgaran, Daniel Martijn de Bruin, F Javier Salguero, Gerben Roelof Borst, Ji-Ying Song, Ton G van Leeuwen, Johannes F de Boer, Tanja Alderliesten, Marcel van Herk
Lung cancer survival is poor, and radiation therapy patients often suffer serious treatment side effects. The esophagus is particularly sensitive leading to acute radiation-induced esophageal damage (ARIED). We investigated the feasibility of optical coherence tomography (OCT) for minimally invasive imaging of the esophagus with high resolution (10  μm) to detect ARIED in mice. Thirty mice underwent cone-beam computed tomography imaging for initial setup assessment and dose planning followed by a single-dose delivery of 4...
April 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29651746/human-neural-stem-progenitor-cells-derived-from-epileptic-human-brain-in-a-self-assembling-peptide-nanoscaffold-improve-traumatic-brain-injury-in-rats
#14
Ali Jahanbazi Jahan-Abad, Sajad Sahab Negah, Hassan Hosseini Ravandi, Sedigheh Ghasemi, Maryam Borhani-Haghighi, Walter Stummer, Ali Gorji, Maryam Khaleghi Ghadiri
Traumatic brain injury (TBI) is a disruption in the brain functions following a head trauma. Cell therapy may provide a promising treatment for TBI. Among different cell types, human neural stem cells cultured in self-assembling peptide scaffolds have been suggested as a potential novel method for cell replacement treatment after TBI. In the present study, we accessed the effects of human neural stem/progenitor cells (hNS/PCs) derived from epileptic human brain and human adipose-derived stromal/stem cells (hADSCs) seeded in PuraMatrix hydrogel (PM) on brain function after TBI in an animal model of brain injury...
April 12, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29651425/microrna-mediated-regulation-of-hmgb1-in-human-hepatocellular-carcinoma
#15
REVIEW
Jianing Yan, Shibo Ying, Xiujun Cai
High-mobility group box 1 (HMGB1) is a potential therapeutic target and novel biomarker in a variety of malignant tumors, including hepatocellular carcinoma (HCC). More recently, a number of microRNAs (miRNAs) are identified as a class of regulators for broad control of HMGB1-mediated biological actions in eukaryotic cells. In this review article we will describe representative miRNAs involved in regulating the HMGB1 signaling pathways in HCC cell lines and/or animal models. We also propose the possible mechanisms underlying the miRNA/HMGB1 axis and discuss the future clinical significance of miRNAs targeting HMGB1 molecule for HCC therapy...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29651391/the-wound-healing-effects-of-herbal-cream-containing-oliveria-decumbens-and-pelargonium-graveolens-essential-oils-in-diabetic-foot-ulcer-model
#16
Mohaddese Mahboubi, Mohsen Taghizadeh, Tahereh Khamechian, Omid Reza Tamtaji, Rasoul Mokhtari, Sayyed Alireza Talaei
BACKGROUND: The number of diabetic patients in adult population is increasing. All this population are at risk of developing diabetic foot ulcers (DFUs) that are associated with unwanted ailments and high mortality. In spite of current therapies for DFUs, further therapies are needed to help the patients. METHODS: The efficacy of herbal cream containing Pelargonium graveolens and Oliveria decombens essential oils was evaluated topically for treatment of DFUs in rat animal model in comparison with two other herbal formulas containing each essential oil alone, placebo (the basic formula without active ingredients) and normal saline as control groups...
January 2018: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29651283/mirnas-in-tuberculosis-new-avenues-for-diagnosis-and-host-directed-therapy
#17
REVIEW
Naveed Sabir, Tariq Hussain, Syed Zahid Ali Shah, Antonio Peramo, Deming Zhao, Xiangmei Zhou
Tuberculosis (TB) is one of the most fatal infectious diseases and a leading cause of mortality, with 95% of these deaths occurring in developing countries. The causative agent, Mycobacterium tuberculosis ( Mtb ), has a well-established ability to circumvent the host's immune system for its intracellular survival. microRNAs (miRNAs) are small, non-coding RNAs having an important function at the post-transcriptional level and are involved in shaping immunity by regulating the repertoire of genes expressed in immune cells...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29651165/the-mitochondrial-citrate-carrier-slc25a1-drives-stemness-and-therapy-resistance-in-non-small-cell-lung-cancer
#18
Harvey R Fernandez, Shreyas M Gadre, Mingjun Tan, Garrett T Graham, Rami Mosaoa, Martin S Ongkeko, Kyu Ah Kim, Rebecca B Riggins, Erika Parasido, Iacopo Petrini, Simone Pacini, Amrita Cheema, Rency Varghese, Habtom W Ressom, Yuwen Zhang, Christopher Albanese, Aykut Üren, Mikell Paige, Giuseppe Giaccone, Maria Laura Avantaggiati
Therapy resistance represents a clinical challenge for advanced non-small cell lung cancer (NSCLC), which still remains an incurable disease. There is growing evidence that cancer-initiating or cancer stem cells (CSCs) provide a reservoir of slow-growing dormant populations of cells with tumor-initiating and unlimited self-renewal ability that are left behind by conventional therapies reigniting post-therapy relapse and metastatic dissemination. The metabolic pathways required for the expansion of CSCs are incompletely defined, but their understanding will likely open new therapeutic opportunities...
April 12, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29651023/generation-of-autochthonous-mouse-models-of-clear-cell-renal-cell-carcinoma-mouse-models-of-renal-cell-carcinoma
#19
REVIEW
Weibin Hou, Zhigang Ji
Renal cell carcinoma (RCC) is one of the 10 most common cancers worldwide, and to date, a strong systemic therapy has not been developed to treat RCC, even with the remarkable modern advances in molecular medicine mostly due to our incomplete understanding of its tumorigenesis. There is a dire unmet need to understand the etiology and progression of RCC, especially the most common subtype, clear cell RCC (ccRCC), and to develop new treatments for RCC. Genetically engineered mouse (GEM) models are able to mimic the initiation, progression, and metastasis of cancer, thus providing valuable insights into tumorigenesis and serving as perfect preclinical platforms for drug testing and biomarker discovery...
April 13, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29651017/effects-of-different-doses-of-granulocyte-colony-stimulating-factor-mobilization-therapy-on-ischemic-cardiomyopathy
#20
Rongchong Huang, Haichen Lv, Kang Yao, Lei Ge, Zhishuai Ye, Huaiyu Ding, Yiqi Zhang, Hao Lu, Zheyong Huang, Shuning Zhang, Yunzeng Zou, Junbo Ge
G-CSF mobilization might be beneficial to ICM, but the relationship between effect/safety and the dosage of G-CSF remains unclear. In this study, 24 pigs were used to build ICM models and were randomized into four groups. Four weeks later, different dosages of G-CSF were given daily by subcutaneous injection for 5 days. Another 4 weeks later, all the animals were sacrificed. Electrocardiography, coronary arteriography, left ventriculography, transthoracic echocardiography, cardiac MRI, and SPECT, histopathologic analysis, and immunohistochemistry techniques were used to evaluate left ventricular function and myocardial infarct size...
April 12, 2018: Scientific Reports
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