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calcium handling

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https://www.readbyqxmd.com/read/29030345/runx1-deficiency-protects-against-adverse-cardiac-remodeling-following-myocardial-infarction
#1
Charlotte S McCarroll, Weihong He, Kirsty Foote, Ashley Bradley, Karen McGlynn, Francesca Vidler, Colin Nixon, Katrin Nather, Caroline Fattah, Alexandra H Riddell, Peter Bowman, Elspeth B Elliott, Margaret Bell, Catherine Hawksby, Scott M MacKenzie, Liam J Morrison, Anne Terry, Karen Blyth, Godfrey L Smith, Martin W McBride, Thomas Kubin, Thomas Braun, Stuart A Nicklin, Ewan R Cameron, Christopher M Loughrey
Background -Myocardial infarction (MI) is a leading cause of heart failure and death worldwide. Preservation of contractile function and protection against adverse changes in ventricular architecture (cardiac remodeling) are key factors to limiting progression of this condition to heart failure. Consequently, new therapeutic targets are urgently required to achieve this aim. Expression of the Runx1 transcription factor is increased in adult cardiomyocytes following MI; however, the functional role of Runx1 in the heart is unknown...
October 13, 2017: Circulation
https://www.readbyqxmd.com/read/29027611/preparation-of-flexible-bone-tissue-scaffold-utilizing-sea-urchin-test-and-collagen
#2
Naga Vijaya Lakshmi Manchinasetty, Sho Oshima, Masanori Kikuchi
Gonads of sea urchin are consumed in Japan and some countries as food and most parts including its tests are discarded as marine wastes. Therefore, utilization of them as functional materials would reduce the waste as well as encourage Japanese fishery. In this study, magnesium containing calcite granules collected from sea urchin tests were hydrothermally phosphatized and the obtained granules were identified as approximately 82% in mass of magnesium containing β-tricalcium phosphate and 18% in mass of nonstoichiometric hydroxyapatite, i...
October 13, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29020304/identification-of-a-targeted-and-testable-antiarrhythmic-therapy-for-long-qt-syndrome-type-2-using-a-patient-specific-cellular-model
#3
Ashish Mehta, Chrishan J A Ramachandra, Pritpal Singh, Anuja Chitre, Chong Hui Lua, Manuela Mura, Lia Crotti, Philip Wong, Peter J Schwartz, Massimiliano Gnecchi, Winston Shim
Aims: Loss-of-function mutations in the hERG gene causes long-QT syndrome type 2 (LQT2), a condition associated with reduced IKr current. Four different mutation classes define the molecular mechanisms impairing hERG. Among them, Class 2 mutations determine hERG trafficking defects. Lumacaftor (LUM) is a drug acting on channel trafficking already successfully tested for cystic fibrosis and its safety profile is well known. We hypothesize that LUM might rescue also hERG trafficking defects in LQT2 and exert anti-arrhythmic effects...
July 21, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29018025/peptidyl-prolyl-isomerase-1-regulates-ca-2-handling-by-modulating-sarco-endo-plasmic-reticulum-calcium-atpase-and-na-2-ca-2-exchanger-1-protein-levels-and-function
#4
Veronica Sacchi, Bingyan J Wang, Dieter Kubli, Alexander S Martinez, Jung-Kang Jin, Roberto Alvarez, Nirmala Hariharan, Christopher Glembotski, Takafumi Uchida, James S Malter, Yijun Yang, Polina Gross, Chen Zhang, Steven Houser, Marcello Rota, Mark A Sussman
BACKGROUND: Aberrant Ca(2+) handling is a prominent feature of heart failure. Elucidation of the molecular mechanisms responsible for aberrant Ca(2+) handling is essential for the development of strategies to blunt pathological changes in calcium dynamics. The peptidyl-prolyl cis-trans isomerase peptidyl-prolyl isomerase 1 (Pin1) is a critical mediator of myocardial hypertrophy development and cardiac progenitor cell cycle. However, the influence of Pin1 on calcium cycling regulation has not been explored...
October 10, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28994249/molecular-pathways-of-estrogen-receptors-and-%C3%AE-adrenergic-receptors-in-cardiac-cells-recognition-of-their-similarities-interactions-and-therapeutic-value
#5
REVIEW
Machuki Ong'achwa Jeremiah, Hong-Yuan Zhang, Sian Harding, Hong Sun
Estrogen receptors (ERs) and β-adrenergic receptors (βARs) play important roles in the cardiovascular system. Moreover, these receptors are expressed in cardiac myocytes and vascular tissues. Numerous experimental observations support the hypothesis that similarities and interactions exist between the signaling pathways of ERs (ERα, ERβ, GPR30) and βARs (β1 , β2 , and β3 AR). The recently discovered estrogen receptor GPR30 shares structural features with the βARs, and this forms the basis for the interactions and functional overlap...
October 9, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28969191/an-attempt-to-make-platelet-rich-fibrin-from-bone-marrow-aspirate
#6
Soh Nishimoto, Kazutoshi Fujita, Toshihiro Fujiwara, Yohei Sotsuka, Maki Tonooka, Hisako Ishise, Kenichiro Kawai, Masao Kakibuchi
INTRODUCTION: Platelet Rich Fibrin (PRF) was developed as a new generation of platelet concentration from peripheral blood. Method to make PRF is simple. It is easy to handle with its moderate firmness. Histologically, platelets and nucleated cells are packed along the yellow-red border. Bone marrow aspirate contains bone marrow cells that potentially work for tissue regeneration, and platelets which contain growth factors. The specific gravities of them are comparable. It implies that, if it is possible to make PRF from bone marrow aspirate, then high concentration of platelets and bone marrow cells can be obtained simultaneously by taking out yellow-red interface of it...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28966992/hepatic-inositol-1-4-5-trisphosphate-receptor-type-1-mediates-fatty-liver
#7
Colleen N Feriod, Andre Gustavo Oliveira, Mateus T Guerra, Lily Nguyen, Kisha Mitchell Richards, Michael J Jurczak, Hai-Bin Ruan, Joao Paulo Camporez, Xiaoyong Yang, Gerald I Shulman, Anton M Bennett, Michael H Nathanson, Barbara E Ehrlich
Fatty liver is the most common type of liver disease, affecting nearly one third of the US population and more than half a billion people worldwide. Abnormalities in ER calcium handling and mitochondrial function each have been implicated in abnormal lipid droplet formation. Here we show that the type 1 isoform of the inositol 1,4,5-trisphosphate receptor (InsP3R1) specifically links ER calcium release to mitochondrial calcium signaling and lipid droplet formation in hepatocytes. Moreover, liver-specific InsP3R1 knockout mice have impaired mitochondrial calcium signaling, decreased hepatic triglycerides, reduced lipid droplet formation and are resistant to development of fatty liver...
February 2017: Hepatol Commun
https://www.readbyqxmd.com/read/28966262/development-of-functional-thin-polymer-films-using-a-layer-by-layer-deposition-technique
#8
Kentaro Yoshida
 Functional thin films containing insulin were prepared using layer-by-layer (LbL) deposition of insulin and negatively- or positively-charged polymers on the surface of solid substrates. LbL films composed of insulin and negatively-charged polymers such as poly(acrylic acid) (PAA), poly(vinylsulfate) (PVS), and dextran sulfate (DS) were prepared through electrostatic affinity between the materials. The insulin/PAA, insulin/PVS, and insulin/DS films were stable in acidic solutions, whereas they decomposed under physiological conditions as a result of a change in the net electric charge of insulin from positive to negative...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28963192/calcium-signaling-and-transcriptional-regulation-in-cardiomyocytes
#9
REVIEW
Matthias Dewenter, Albert von der Lieth, Hugo A Katus, Johannes Backs
Calcium (Ca(2+)) is a universal regulator of various cellular functions. In cardiomyocytes, Ca(2+) is the central element of excitation-contraction coupling, but also impacts diverse signaling cascades and influences the regulation of gene expression, referred to as excitation-transcription coupling. Disturbances in cellular Ca(2+)-handling and alterations in Ca(2+)-dependent gene expression patterns are pivotal characteristics of failing cardiomyocytes, with several excitation-transcription coupling pathways shown to be critically involved in structural and functional remodeling processes...
September 29, 2017: Circulation Research
https://www.readbyqxmd.com/read/28958611/clevidipine-for-hypertension-treatment-in-pheochromocytoma-surgery
#10
C Luis-García, E Arbonés-Aran, C Teixell-Aleu, L Lorente-Poch, L Trillo-Urrutia
Pheochromocytoma is a catecholamine-producing tumour and laparoscopic adrenalectomy is its treatment of choice. During pneumoperitoneum insufflation and tumour handling there is a high risk of massive catecholamine release and hypertensive crisis. After tumour excision, severe arterial hypotension is a common effect, due to relative vasodilation and the residual effect of antihypertensive drugs. We report the case of a patient with pheochromocytoma who was treated with laparoscopic adrenalectomy. During surgical manipulation there was a sudden hypertensive peak that could be controlled quickly with clevidipine infusion...
September 25, 2017: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/28956314/new-insights-in-cardiac-calcium-handling-and-excitation-contraction-coupling
#11
Jessica Gambardella, Bruno Trimarco, Guido Iaccarino, Gaetano Santulli
Excitation-contraction (EC) coupling denotes the conversion of electric stimulus in mechanic output in contractile cells. Several studies have demonstrated that calcium (Ca(2+)) plays a pivotal role in this process. Here we present a comprehensive and updated description of the main systems involved in cardiac Ca(2+) handling that ensure a functional EC coupling and their pathological alterations, mainly related to heart failure.
September 28, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28947942/discovery-of-an-isothiazole-based-phenylpropanoic-acid-gpr120-agonist-as-a-development-candidate-for-type-2-diabetes
#12
Xuqing Zhang, Chaozhong Cai, Zhihua Sui, Mark Macielag, Yuanping Wang, Wen Yan, Arthur Suckow, Hong Hua, Austin Bell, Peter Haug, Wilma Clapper, Celia Jenkinson, Joseph Gunnet, James Leonard, William V Murray
We have discovered a novel series of isothiazole-based phenylpropanoic acids as GPR120 agonists. Extensive structure-activity relationship studies led to the discovery of a potent GPR120 agonist 4x, which displayed good EC50 values in both calcium and β-arrestin assays. It also presented good pharmaceutical properties and a favorable PK profile. Moreover, it demonstrated in vivo antidiabetic activity in C57BL/6 DIO mice. Studies in WT and knockout DIO mice showed that it improved glucose handling during an OGTT via GPR120...
September 14, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28946496/ultrasonically-enhanced-preparation-characterization-of-cafe-layered-double-hydroxides-with-various-interlayer-halide-azide-and-oxo-anions-co3-2-no3-clo4
#13
Márton Szabados, Gábor Varga, Zoltán Kónya, Ákos Kukovecz, Stefan Carlson, Pál Sipos, István Pálinkó
An ultrasonically-enhanced mechanochemical method was developed to synthesize CaFe-layered double hydroxides (LDHs) with various interlayer anions (CO3(2-), NO3(-), ClO4(-), N3(-), F(-), Cl(-), Br(-) and I(-)). The duration of pre-milling and ultrasonic irradiation and the variation of synthesis temperature in the wet chemical step were investigated to obtain the optimal parameters of preparation. The main method to characterize the products was X-ray diffractometry, but infrared and synchrotron-based X-ray absorption spectroscopies as well as thermogravimetric measurements were also used to learn about fine structural details...
January 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28941705/severe-dcm-phenotype-of-patient-harboring-rbm20-mutation-s635a-can-be-modeled-by-patient-specific-induced-pluripotent-stem-cell-derived-cardiomyocytes
#14
Katrin Streckfuss-Bömeke, Malte Tiburcy, Andrey Fomin, Xiaojing Luo, Wener Li, Claudia Fischer, Cemil Özcelik, Andreas Perrot, Samuel Sossalla, Jan Haas, Ramon Oliveira Vidal, Sabine Rebs, Sara Khadjeh, Benjamin Meder, Stefan Bonn, Wolfgang A Linke, Wolfram-Hubertus Zimmermann, Gerd Hasenfuss, Kaomei Guan
The ability to generate patient-specific induced pluripotent stem cells (iPSCs) provides a unique opportunity for modeling heart disease in vitro. In this study, we generated iPSCs from a patient with dilated cardiomyopathy (DCM) caused by a missense mutation S635A in RNA-binding motif protein 20 (RBM20) and investigated the functionality and cell biology of cardiomyocytes (CMs) derived from patient-specific iPSCs (RBM20-iPSCs). The RBM20-iPSC-CMs showed abnormal distribution of sarcomeric α-actinin and defective calcium handling compared to control-iPSC-CMs, suggesting disorganized myofilament structure and altered calcium machinery in CMs of the RBM20 patient...
September 21, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28917714/mitochondria-in-the-nervous-system-from-health-to-disease-part-i
#15
EDITORIAL
Brian M Polster, Maria Teresa Carrì, Philip M Beart
In Part I of this Special Issue on "Mitochondria in the Nervous System: From Health to Disease", the editors bring together contributions from experts in brain mitochondrial research to provide an up-to-date overview of mitochondrial functioning in physiology and pathology. The issue provides cutting edge reviews on classical areas of mitochondrial biology that include energy substrate utilization, calcium handling, mitochondria-endoplasmic reticulum communication, and cell death regulation. Additional reviews and original research articles touch upon key mitochondrial defects seen across multiple neurodegenerative conditions, including fragmentation, loss of respiratory capacity, calcium overload, elevated reactive oxygen species generation, perturbed NAD(+) metabolism, altered protein acetylation, and compromised mitophagy...
October 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28915538/long-term-t3-and-t4-treatment-as-an-alternative-to-aerobic-exercise-training-in-improving-cardiac-function-post-myocardial-infarction
#16
Rayane Brinck Teixeira, Alexsandra Zimmer, Alexandre Luz de Castro, Bruna Gazzi de Lima-Seolin, Patrick Türck, Rafaela Siqueira, Adriane Belló-Klein, Pawan K Singal, Alex Sander da Rosa Araujo
Here we aimed to compare the beneficial effects of T3 and T4 hormone treatment to those provided by aerobic exercise training in Wistar rats post-myocardial infarction (MI). Rats in one group were SHAM-operated and in the other group were subjected to MI surgery. One week after surgery, the MI group animals either received T3 and T4 hormones by gavage or underwent a low intensity aerobic exercise training protocol on a treadmill, and both treatments lasted until 10 weeks after MI. Untreated SHAM-operated and MI groups were also followed for the same duration...
September 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28894423/%C3%AE-adrenergic-inhibition-prevents-action-potential-and-calcium-handling-changes-during-regional-myocardial-ischemia
#17
Shannon R Murphy, Lianguo Wang, Zhen Wang, Philip Domondon, Di Lang, Beth A Habecker, Rachel C Myles, Crystal M Ripplinger
β-adrenergic receptor (β-AR) blockers may be administered during acute myocardial infarction (MI), as they reduce energy demand through negative chronotropic and inotropic effects and prevent ischemia-induced arrhythmogenesis. However, the direct effects of β-AR blockers on ventricular electrophysiology and intracellular Ca(2+) handling during ischemia remain unknown. Using optical mapping of transmembrane potential (with RH237) and sarcoplasmic reticulum (SR) Ca(2+) (with the low-affinity indicator Fluo-5N AM), the effects of 15 min of regional ischemia were assessed in isolated rabbit hearts (n = 19)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28892318/-lipertance%C3%A2-the-ascot-single-pill-combination-has-finally-arrived
#18
REVIEW
R P Radermecker
The fixed association of atorvastatin, perindopril and amlodipine was recently launched by the firm SERVIER under the name of Lipertance®. It is the first fixed association of a statin, an ACE inhibitor and a calcium blocker present on the Belgian market to handle the risk factors that are hypertension and dyslipidemia which can be used both in primary and secondary cardiovascular prevention. The interests of such a triple combined therapy are many in terms of morbimortality reduction, as observed in ASCOT trial...
September 2017: Revue Médicale de Liège
https://www.readbyqxmd.com/read/28888328/a-population-based-approach-to-assess-the-heritability-and-distribution-of-renal-handling-of-electrolytes
#19
Flore Moulin, Belen Ponte, Menno Pruijm, Daniel Ackermann, Yassine Bouatou, Idris Guessous, Georg Ehret, Olivier Bonny, Antoinette Pechère-Bertschi, Jan A Staessen, Fred Paccaud, Pierre-Yves Martin, Michel Burnier, Bruno Vogt, Olivier Devuyst, Murielle Bochud
The handling of electrolytes by the kidney is essential for homeostasis. However, the heritability of these processes, the first step in gene discovery, is poorly known. To help clarify this, we estimated the heritability of serum concentration, urinary excretion, renal clearance, and fractional excretion of sodium, potassium, magnesium, calcium, phosphate, and chloride in a population-based study. Nuclear families were randomly selected from the general population in Lausanne, Geneva, and Bern, Switzerland, and urine collected over 24-hour periods...
September 6, 2017: Kidney International
https://www.readbyqxmd.com/read/28888007/nano%C3%A2-calcium-phosphate-bone-cement-based-on-si-stabilized-%C3%AE-tricalcium-phosphate-with-improved-mechanical-properties
#20
M Roozbahani, M Alehosseini, M Kharaziha, R Emadi
This study aimed to develop nano‑calcium phosphate cement (nCPC) and evaluate the effect of nanosized precursors on mechanical, physical and handling properties (injectability and setting time) as well as conversion rate of nano-reactants into nano-hydroxyapatite (nHA). In this study, while alpha tricalcium phosphate (α-TCP, 98wt%) and HA (2wt%) were applied as the powder phase, 2.5wt% NaH2PO4 solution was used as liquid phase of cement. Before nano-CPC preparation, Si-stabilized α-TCP nanopowder with particle size of 10±3...
December 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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