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https://www.readbyqxmd.com/read/28431123/surgical-intervention-for-ground-glass-dominant-lesions-observation-or-outright-resection
#1
Mariko Fukui, Kenji Suzuki, Takeshi Matsunaga, Shiaki Oh, Kazuya Takamochi
Background: The management of ground glass opacity (GGO) on computed tomography (CT) remains controversial. Information of the relationship between clinical behavior and pathological invasiveness of GGO is valuable for management. We conducted this retrospective study to establish differences in the pathological invasiveness between GGO with and without changes. Methods: Among 1762 patients, the following criteria was used: (1) maximum tumor diameter of 3 cm or less, (2) tumor having 50% or more GGO and (3) resection after at least three months of follow up...
April 18, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28430397/respiratory-virus-detection-during-hospitalisation-for-lower-respiratory-tract-infection-in-children-under-2-years-in-south-auckland-new-zealand
#2
Adrian A Trenholme, Emma J Best, Alison M Vogel, Joanna M Stewart, Charissa J Miller, Diana R Lennon
AIM: To describe respiratory virus detection in children under 2 years of age in a population admitted with lower respiratory infection and to assess correlation with measures of severity. METHODS: Nasopharyngeal aspirates from infants admitted with lower respiratory tract infection (n = 1645) over a 3-year time period were tested by polymerase chain reaction. We collected epidemiological and clinical data on all children. We assessed the correlation of presence of virus with length of hospital stay, intensive care admission and consolidation on chest X-ray...
April 21, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28429379/retrospective-evaluation-of-thoracic-computed-tomography-findings-in-dogs-naturally-infected-by-angiostrongylus-vasorum
#3
Mark E Coia, Gawain Hammond, Daniel Chan, Randi Drees, David Walker, Kevin Murtagh, Janine Stone, Nicholas Bexfield, Lizzie Reeve, Jenny Helm
Angiostrongylus vasorum (A. vasorum) is an important emerging disease of canidae. Cardiorespiratory signs are common in affected dogs, therefore thoracic imaging is critical for diagnosing and monitoring disease. Descriptions of thoracic computed tomography (CT) findings in dogs naturally infected with A. vasorum are currently lacking. Aims of this multicenter, retrospective study were to describe thoracic CT findings in a group of dogs with confirmed disease, determine whether any changes were consistent among dogs, and propose standardized terms for describing thoracic CT findings...
April 20, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28428165/a-framework-for-the-study-of-complex-mhealth-interventions-in-diverse-cultural-settings
#4
Marion A Maar, Karen Yeates, Nancy Perkins, Lisa Boesch, Diane Hua-Stewart, Peter Liu, Jessica Sleeth, Sheldon W Tobe
BACKGROUND: To facilitate decision-making capacity between options of care under real-life service conditions, clinical trials must be pragmatic to evaluate mobile health (mHealth) interventions under the variable conditions of health care settings with a wide range of participants. The mHealth interventions require changes in the behavior of patients and providers, creating considerable complexity and ambiguity related to causal chains. Process evaluations of the implementation are necessary to shed light on the range of unanticipated effects an intervention may have, what the active ingredients in everyday practice are, how they exert their effect, and how these may vary among recipients or between sites...
April 20, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28427677/ultrasonic-hot-powder-compaction-of-ti-6al-4v
#5
Rezvan Abedini, Amir Abdullah, Yunes Alizadeh
Power ultrasonic has been recently employed in a wide variety of manufacturing processes among which ultrasonic assisted powder compaction is a promising powder materials processing technique with significant industrial applications. The products manufactured by the powder metallurgy commonly consist of residual porosities, material impurities, structural non-homogeneities and residual stress. In this paper, it is aimed to apply power ultrasonic to the hot consolidation process of Ti-6Al-4V titanium alloy powder in order to improve mechanical properties...
July 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28427529/primary-central-nervous-system-lymphoma
#6
REVIEW
Giovanni Citterio, Michele Reni, Gemma Gatta, Andrés José Maria Ferreri
Primary CNS lymphomas (PCNSL) represent a subgroup of malignancies with specific characteristics, aggressive course, and unsatisfactory outcome in contrast with other lymphomas comparable for tumour burden and/or histological type. Despite a high chemo- and radiosensitivity, remissions are frequently shortlasting, mainly because the blood brain-barrier limits the access of many drugs to the CNS. Moreover, survivor patients are at high risk of developing severe treatment-related toxicity, mainly disabling neurotoxicity, raising the question of how to balance therapy intensification with side-effects control...
May 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28427520/lymphoblastic-lymphoma
#7
REVIEW
Sergio Cortelazzo, Andrés Ferreri, Dieter Hoelzer, Maurilio Ponzoni
Lymphoblastic lymphoma (LBL) is a neoplasm of immature B cells committed to the B-(B-LBL) or T-cell lineage (T-LBL) that accounts for approximately 2% of all lymphomas. Although histological features are usually sufficient to distinguish lymphoblastic from mature B- or T-cell neoplasms, of greater importance for diagnosis is the characterization of immunophenotype by flow cytometry. LBL occurs more commonly in children than in adults, mostly in males. A bone marrow involvement <25% (or 20% according to WHO) formally distinguishes LBL from ALL...
May 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28427506/recent-advances-in-genitourinary-tumors-a-review-focused-on-biology-and-systemic-treatment
#8
REVIEW
Aránzazu González Del Alba, José Ángel Arranz, Javier Puente, María José Méndez-Vidal, Enrique Gallardo, Enrique Grande, Begoña Pérez-Valderrama, Enrique González-Billalabeitia, Martín Lázaro-Quintela, Álvaro Pinto, Nuria Lainez, Josep M Piulats, Emilio Esteban, José Pablo Maroto Rey, Jorge A García, Cristina Suárez
Updated information published up to 2016 regarding major advances in renal cancer, bladder cancer, and prostate cancer is here presented. Based on an ever better understanding of the genetic and molecular alterations that govern the initial pathogenic mechanisms of tumor oncogenesis, an improvement in the characterization and treatment of urologic tumors has been achieved in the past year. According to the Cancer Genome Atlas (ATLAS) project, alterations in the MET pathway are characteristics of type 1 papillary renal cell carcinomas, and activation of NRF2-ARE pathway is associated with the biologically distinct type 2...
May 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28427280/progress-in-terpene-synthesis-strategies-through-engineering-of-saccharomyces-cerevisiae
#9
Kalaivani Paramasivan, Sarma Mutturi
Terpenes are natural products with a remarkable diversity in their chemical structures and they hold a significant market share commercially owing to their distinct applications. These potential molecules are usually derived from terrestrial plants, marine and microbial sources. In vitro production of terpenes using plant tissue culture and plant metabolic engineering, although receiving some success, the complexity in downstream processing because of the interference of phenolics and product commercialization due to regulations that are significant concerns...
April 20, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28426969/chemogenetic-interrogation-of-a-brain-wide-fear-memory-network-in-mice
#10
Gisella Vetere, Justin W Kenney, Lina M Tran, Frances Xia, Patrick E Steadman, John Parkinson, Sheena A Josselyn, Paul W Frankland
Behavior depends on coordinated activity across multiple brain regions. Within such networks, highly connected hub regions are assumed to disproportionately influence behavioral output, although this hypothesis has not been systematically evaluated. Previously, by mapping brain-wide expression of the activity-regulated gene c-fos, we identified a network of brain regions co-activated by fear memory. To test the hypothesis that hub regions are more important for network function, here, we simulated node deletion in silico in this behaviorally defined functional network...
April 19, 2017: Neuron
https://www.readbyqxmd.com/read/28426955/the-small-world-of-a-fear-memory
#11
Nicholas I Woods, Mazen A Kheirbek
How are fear memories organized? In this issue of Neuron, Vetere et al. (2017) take a network-based approach to demonstrate the importance of highly interconnected hub regions in the consolidation of a fear memory. By doing so, they provide an elegant framework for predicting behavior from functional network properties.
April 19, 2017: Neuron
https://www.readbyqxmd.com/read/28426128/hippocampal-electrical-stimulation-disrupts-associative-learning-when-targeted-at-dentate-spikes
#12
Miriam S Nokia, Irina Gureviciene, Tomi Waselius, Heikki Tanila, Markku Penttonen
Hippocampal electrophysiological oscillations, namely theta and ripples, have been implicated in encoding and consolidation of new memories, respectively. According to existing literature, hippocampal dentate spikes are prominent, short-duration (<30 ms), large-amplitude (∼2-4 mV) fluctuations in hilar local-field potentials that take place during awake immobility and sleep. Interestingly, previous studies indicate that during dentate spikes dentate gyrus granule cells increase their firing while firing of CA1 pyramidal cells are suppressed, thus resulting in momentary uncoupling of the two hippocampal subregions...
April 20, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28425640/profiling-of-the-silica-induced-molecular-events-in-lung-epithelial-cells-using-the-rna-seq-approach
#13
Judy Y W Chan, Joseph C C Tsui, Patrick T W Law, Winnie K W So, Doris Y P Leung, Michael M K Sham, Stephen K W Tsui, Carmen W H Chan
Silicosis is a prolonged, irreversible and incurable occupational disease, and there is a significant number of newly diagnosed cases every year in Hong Kong. Due to the long latency of the disease, the diagnosis can be missed until detailed clinical examination at a later stage. For a better control of this deadly disease, detailing the pro-inflammatory and fibrotic events in the macrophage would be instrumental in understanding the pathogenesis of the disease and essential for the significant biomarkers discovery...
April 20, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28425574/factors-associated-with-sustainability-of-2-quality-improvement-programs-after-achieving-early-implementation-success-a-qualitative-case-study
#14
Stephanie M C Ament, Freek Gillissen, Albine Moser, José M C Maessen, Carmen D Dirksen, Maarten F von Meyenfeldt, Trudy van der Weijden
RATIONALE, AIMS, AND OBJECTIVES: Sustainability of innovations is a relatively new concept in health care research and has become an issue of growing interest. The current study explored factors related to the sustainability of 2 multidisciplinary hospital-based programs 3 to 6 years after achieving early implementation success. METHOD: An exploratory qualitative study was conducted into 2 implementation cases, an Enhanced Recovery After Surgery program for colorectal surgery and a short-stay program for breast cancer surgery...
April 20, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28424853/long-term-results-of-ankle-arthrodesis-in-children-and-adolescents-with-haemophilia
#15
Nicolas de l'Escalopier, Alina Badina, Jean Paul Padovani, Annie Harroche, Laurent Frenzel, Philippe Wicart, Christophe Glorion, Chantal Rothschild
INTRODUCTION: Ankle arthrodesis in patients with haemophilia is a joint-non-preserving treatment option often resulting in substantial pain relief and termination of haemarthrosis by osseous consolidating of the joint. However, limited data are available regarding ankle arthrodesis in young patients. AIM: The aim of this study was to evaluate the long-term clinical and radiographic results with a minimum follow-up of ten years in children with haemophilia who underwent ankle arthrodesis...
April 20, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28424596/non-interfering-effects-of-active-post-encoding-tasks-on-episodic-memory-consolidation-in-humans
#16
Samarth Varma, Atsuko Takashima, Sander Krewinkel, Maaike van Kooten, Lily Fu, W Pieter Medendorp, Roy P C Kessels, Sander M Daselaar
So far, studies that investigated interference effects of post-learning processes on episodic memory consolidation in humans have used tasks involving only complex and meaningful information. Such tasks require reallocation of general or encoding-specific resources away from consolidation-relevant activities. The possibility that interference can be elicited using a task that heavily taxes our limited brain resources, but has low semantic and hippocampal related long-term memory processing demands, has never been tested...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28424592/new-implications-for-the-melanocortin-system-in-alcohol-drinking-behavior-in-adolescents-the-glial-dysfunction-hypothesis
#17
Juan A Orellana, Waldo Cerpa, Maria F Carvajal, José M Lerma-Cabrera, Eduardo Karahanian, Cesar Osorio-Fuentealba, Rodrigo A Quintanilla
Alcohol dependence causes physical, social, and moral harms and currently represents an important public health concern. According to the World Health Organization (WHO), alcoholism is the third leading cause of death worldwide, after tobacco consumption and hypertension. Recent epidemiologic studies have shown a growing trend in alcohol abuse among adolescents, characterized by the consumption of large doses of alcohol over a short time period. Since brain development is an ongoing process during adolescence, short- and long-term brain damage associated with drinking behavior could lead to serious consequences for health and wellbeing...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28423576/solitary-ground-glass-opacity-nodules-of-stage-ia-pulmonary-adenocarcinoma-combination-of-18f-fdg-pet-ct-and-high-resolution-computed-tomography-features-to-predict-invasive-adenocarcinoma
#18
Jun Zhou, Yanli Li, Yiqiu Zhang, Guobing Liu, Hui Tan, Yan Hu, Jie Xiao, Hongcheng Shi
To investigate the performance of combined 18F-FDG Positron Emission Tomography/Computed Tomography with high-resolution CT for differentiating invasive adenocarcinoma from adenocarcinoma in situ (pre-invasive lesion) or minimally invasive adenocarcinoma in stage IA lung cancer patients with solitary ground-glass opacity nodules. This retrospective study enrolled 58 consecutive stage IA pulmonary adenocarcinoma patients with solitary ground-glass opacity nodules. The characteristics and measurements of the ground-glass opacity nodules as pure ground-glass opacity nodules and mixed ground-glass opacity nodules in the pre-invasive or minimally invasive adenocarcinoma and invasive adenocarcinoma groups on Positron Emission Tomography/Computed Tomography and high-resolution CT were compared and analyzed...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28423058/accurate-phenotyping-reconciling-approaches-through-bayesian-model-averaging
#19
Carla Chia-Ming Chen, Jonathan Macgregor Keith, Kerrie Lee Mengersen
Genetic research into complex diseases is frequently hindered by a lack of clear biomarkers for phenotype ascertainment. Phenotypes for such diseases are often identified on the basis of clinically defined criteria; however such criteria may not be suitable for understanding the genetic composition of the diseases. Various statistical approaches have been proposed for phenotype definition; however our previous studies have shown that differences in phenotypes estimated using different approaches have substantial impact on subsequent analyses...
2017: PloS One
https://www.readbyqxmd.com/read/28422976/reactivation-or-transformation-motor-memory-consolidation-associated-with-cerebral-activation-time-locked-to-sleep-spindles
#20
Stuart Fogel, Genevieve Albouy, Bradley R King, Ovidiu Lungu, Catherine Vien, Arnaud Bore, Basile Pinsard, Habib Benali, Julie Carrier, Julien Doyon
Motor memory consolidation is thought to depend on sleep-dependent reactivation of brain areas recruited during learning. However, up to this point, there has been no direct evidence to support this assertion in humans, and the physiological processes supporting such reactivation are unknown. Here, simultaneous electroencephalographic and functional magnetic resonance imaging (EEG-fMRI) recordings were conducted during post-learning sleep to directly investigate the spindle-related reactivation of a memory trace formed during motor sequence learning (MSL), and its relationship to overnight enhancement in performance (reflecting consolidation)...
2017: PloS One
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