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https://www.readbyqxmd.com/read/28214898/early-development-of-parvalbumin-somatostatin-and-cholecystokinin-expressing-neurons-in-rat-brain-following-prenatal-immune-activation-and-maternal-iron-deficiency
#1
Patricia Boksa, Ying Zhang, Dominique Nouel, Alice Wong, Tak Pan Wong
Prenatal maternal infection and maternal iron deficiency during pregnancy are 2 early environmental insults associated with increased risk for schizophrenia in offspring. Substantial evidence suggests that abnormalities in inhibitory γ-aminobutyric acid (GABA) interneuron function, especially in the parvalbumin subtype of GABA interneuron, both developmentally and in adulthood, may contribute mechanistically to cognitive deficits and psychotic symptoms in schizophrenia. This study used a rat model to test whether prenatal immune activation with lipopolysaccharide (LPS; at gestation days, GD, 15 and 16) or maternal iron deficiency (from GD2 to postnatal day P7) or the combination of both insults alters major subtypes of GABAergic interneurons (parvalbumin, somatostatin, cholecystokinin) in brain regions relevant to schizophrenia (medial and dorsolateral prefrontal cortex [PFC], hippocampal CA1 and dentate gyrus, ventral subiculum) in offspring at P14 or P28...
February 18, 2017: Developmental Neuroscience
https://www.readbyqxmd.com/read/28214602/impact-of-fill-level-in-twin-screw-granulation-on-critical-quality-attributes-of-granules-and-tablets
#2
Robin Meier, Klaus-Peter Moll, Markus Krumme, Peter Kleinebudde
In a previous study a change of the fill-level in the barrel exerted a huge influence on the twin-screw granulation (TSG) process of a high drug loaded, simplified formulation. The present work investigated this influence systematically. The specific feed load (SFL) indicating the mass per revolution as surrogate parameter for the fill-level was applied and the correlation to the real volumetric fill level of an extruder could be demonstrated by a newly developed method. A design of experiments was conducted to examine the combined influence of SFL and screw speed on the process and on critical quality attributes of granules and tablets...
February 15, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28213771/a-novel-spiroindoline-targets-cell-cycle-and-migration-via-modulation-of-microtubule-cytoskeleton
#3
Naveen Kumar, Santanu Hati, Parthapratim Munshi, Subhabrata Sen, Seema Sehrawat, Shailja Singh
Natural product-inspired libraries of molecules with diverse architectures have evolved as one of the most useful tools for discovering lead molecules for drug discovery. In comparison to conventional combinatorial libraries, these molecules have been inferred to perform better in phenotypic screening against complicated targets. Diversity-oriented synthesis (DOS) is a forward directional strategy to access such multifaceted library of molecules. From a successful DOS campaign of a natural product-inspired library, recently a small molecule with spiroindoline motif was identified as a potent anti-breast cancer compound...
February 17, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28213398/foxo-integration-of-insulin-signaling-with-glucose-and-lipid-metabolism
#4
Sojin Lee, Henry H Dong
The forkhead box O family consists of FoxO1, FoxO3, FoxO4 and FoxO6 proteins in mammals. Expressed ubiquitously in the body, the four FoxO isoforms share in common the amino DNA binding domain, known as "forkhead box" domain. They mediate the inhibitory action of insulin or insulin-like growth factor on key functions involved in cell metabolism, growth, differentiation, oxidative stress, senescence, autophagy and aging. Genetic mutations in FoxO genes or abnormal expression of FoxO proteins are associated with metabolic disease, cancer or altered lifespan in humans and animals...
February 17, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28213162/the-effect-of-lamotrigine-on-learning-in-mice-using-the-passive-avoidance-model
#5
Fatemeh Izadpanah, Fatemeh Arab, Amin Zarghami, Ali Bijani, Sohrab Kazemi, Ali Akbar Moghadamnia
INTRODUCTION: Lamotrigine (LTG) is an antiepileptic drug that inhibits the release of glutamate by blocking sodium channels. The present study was conducted to evaluate the effect of LTG in different stages of memory using a passive avoidance learning task in mice. METHODS: Male albino mice in the weight range 20-25g were used. They were divided into four groups (control group and three groups receiving various doses of LTG). LTG was given in three doses of 10, 25, and 50mg/kg as intraperitoneal (IP) injections...
February 14, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28212957/a-systematic-review-of-health-economics-simulation-models-of-chronic-obstructive-pulmonary-disease
#6
REVIEW
Zafar Zafari, Stirling Bryan, Don D Sin, Tania Conte, Rahman Khakban, Mohsen Sadatsafavi
BACKGROUND: Many decision-analytic models with varying structures have been developed to inform resource allocation in chronic obstructive pulmonary disease (COPD). OBJECTIVES: To review COPD models for their adherence to the best practice modeling recommendations and their assumptions regarding important aspects of the natural history of COPD. METHODS: A systematic search of English articles reporting on the development or application of a decision-analytic model in COPD was performed in MEDLINE, Embase, and citations within reviewed articles...
January 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28212946/divergent-effects-of-brain-interleukin-1%C3%A3-in-mediating-fever-lethargy-anorexia-and-conditioned-fear-memory
#7
Tamzyn L Baartman, Tanya Swanepoel, Ruth M Barrientos, Helen P Laburn, Duncan Mitchell, Lois M Harden
The influence of brain interleukin-1 (IL-1ß) on memory processes includes both detrimental and beneficial effects. To further explore the dynamics of brain IL-1ß in mediating learning and memory during acute sickness, we injected species-homologous rat IL-1ß (100ng/5μl) or vehicle (0.1% bovine serum albumin, 5μl) directly into the cisterna magna (i.c.m.) of male Sprague-Dawley rats. We measured, in parallel, body temperature, food intake, body mass, cage activity, as well as learning and memory using contextual fear conditioning...
February 14, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28212606/the-implementation-of-health-promotion-in-primary-and-community-care-a-qualitative-analysis-of-the-prescribe-vida-saludable-strategy
#8
Catalina Martinez, Gonzalo Bacigalupe, Josep M Cortada, Gonzalo Grandes, Alvaro Sanchez, Haizea Pombo, Paola Bully
BACKGROUND: The impact of lifestyle on health is undeniable and effective healthy lifestyle promotion interventions do exist. However, this is not a fundamental part of routine primary care clinical practice. We describe factors that determine changes in performance of primary health care centers involved in piloting the health promotion innovation 'Prescribe Vida Saludable' (PVS) phase II. METHODS: We engaged four primary health care centers of the Basque Healthcare Service in an action research project aimed at changing preventive health practices...
February 17, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28211489/sleep-supports-the-slow-abstraction-of-gist-from-visual-perceptual-memories
#9
Nicolas D Lutz, Susanne Diekelmann, Patricia Hinse-Stern, Jan Born, Karsten Rauss
Sleep benefits the consolidation of individual episodic memories. In the long run, however, it may be more efficient to retain the abstract gist of single, related memories, which can be generalized to similar instances in the future. While episodic memory is enhanced after one night of sleep, effective gist abstraction is thought to require multiple nights. We tested this hypothesis using a visual Deese-Roediger-McDermott paradigm, examining gist abstraction and episodic-like memory consolidation after 20 min, after 10 hours, as well as after one year of retention...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28210638/an-unusual-suspect-causing-hypoxemic-respiratory-failure
#10
Masooma Aqeel, Bjorn Batdorf, Horatiu Olteanu, Jayshil J Patel
Introduction: Antisynthetase syndrome (ASS) is characterized by the presence of anti-Jo-1 antibodies in conjunction with clinical findings of fever, polymyositis-dermatomyositis, and interstitial lung disease (ILD). Inflammatory myopathies carry a high risk of malignancy, but this association is less well outlined in ASS. We present the case of a patient with ASS who developed non-Hodgkin's lymphoma with acute hypoxemic respiratory failure. Case Presentation: A 44-year-old female with ASS presented with acute hypoxemic respiratory failure...
January 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/28210330/common-things-are-common-but-not-always-the-answer
#11
Kevin Conroy, Joe Mackenzie, Stephen Cowie
Infection and malignancy are common causes of consolidation but are not always the answer! http://ow.ly/p5LK301PziB.
December 2016: Breathe
https://www.readbyqxmd.com/read/28209514/plasma-metabolite-score-correlates-with-hypoxia-time-in-a-newly-born-piglet-model-for-asphyxia
#12
Julia Kuligowski, Rønnaug Solberg, Ángel Sánchez-Illana, Leonid Pankratov, Anna Parra-Llorca, Guillermo Quintás, Ola Didrik Saugstad, Máximo Vento
Hypoxic-ischemic encephalopathy (HIE) secondary to perinatal asphyxia is a leading cause of mortality and acquired long-term neurologic co-morbidities in the neonate. The most successful intervention for the treatment of moderate to severe HIE is moderate whole body hypothermia initiated within 6h from birth. The objective and prompt identification of infants who are at risk of developing moderate to severe HIE in the critical first hours still remains a challenge. This work proposes a metabolite score calculated based on the relative intensities of three metabolites (choline, 6,8-dihydroxypurine and hypoxanthine) that showed maximum correlation with hypoxia time in a consolidated piglet model for neonatal hypoxia-ischemia...
February 7, 2017: Redox Biology
https://www.readbyqxmd.com/read/28209041/-pulmonary-intravascular-large-b-cell-lymphomamanifesting-as-interstitial-pneumonias-report-of-2-cases-and-review-of-literature
#13
T T Zhao, M S Cao, Y W Zhang, J H Dai, F Q Meng, H R Cai
Objective: To investigate the clinical, radiographic characteristics and prognosis of pulmonary intravascular large B-cell lymphoma(IVLBCL) manifesting as interstitial pneumonias on HRCT. Methods: A retrospective analysis was carried out on clinical data of 2 patients with pulmonary IVLBCL admitted to the Affiliated Drum Tower Hospital of Nanjing University from March 2010 to May 2012. A literature research was performed with "pulmonary intravascular lymphoma" as the key word in Wanfang Database, China Knowledge Resource Integrated Database and Pubmed...
February 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28208433/nonorthogonal-central-moments-based-lattice-boltzmann-scheme-in-three-dimensions
#14
Alessandro De Rosis
We present an alternative three-dimensional lattice Boltzmann collision operator consisting of a nonorthogonal basis of central moments. Our formulation is characterized by an intelligible derivation with a relatively simple and quite general implementation. It is successfully validated against several established, well-consolidated, well-defined benchmark problems, showing excellent properties in terms of accuracy and convergence. If compared to the adoption of the classical Bhatnagar-Gross-Krook operator, our model possesses superior stability...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28207863/identification-of-age-dependent-motor-and-neuropsychological-behavioural-abnormalities-in-a-mouse-model-of-mucopolysaccharidosis-type-ii
#15
Hélène F E Gleitz, Claire O'Leary, Rebecca J Holley, Brian W Bigger
Severe mucopolysaccharidosis type II (MPS II) is a progressive lysosomal storage disease caused by mutations in the IDS gene, leading to a deficiency in the iduronate-2-sulfatase enzyme that is involved in heparan sulphate and dermatan sulphate catabolism. In constitutive form, MPS II is a multi-system disease characterised by progressive neurocognitive decline, severe skeletal abnormalities and hepatosplenomegaly. Although enzyme replacement therapy has been approved for treatment of peripheral organs, no therapy effectively treats the cognitive symptoms of the disease and novel therapies are in development to remediate this...
2017: PloS One
https://www.readbyqxmd.com/read/28207842/evaluating-evidence-based-health-care-teaching-and-learning-in-the-undergraduate-human-nutrition-occupational-therapy-physiotherapy-and-speech-language-and-hearing-therapy-programs-at-a-sub-saharan-african-academic-institution
#16
Anel Schoonees, Anke Rohwer, Taryn Young
BACKGROUND: It is important that all undergraduate healthcare students are equipped with evidence-based health care (EBHC) knowledge and skills to encourage evidence-informed decision-making after graduation. We assessed EBHC teaching and learning in undergraduate human nutrition (HN); occupational therapy (OT); physiotherapy (PT); and speech, language and hearing therapy (SPLH) programs at a sub-Saharan African university. METHODS: We used methodological triangulation to obtain a comprehensive understanding of EBHC teaching and learning: (1) through a document review of module guides, we identified learning outcomes related to pre-specified EBHC competencies; we conducted (2) focus group discussions and interviews of lecturers to obtain their perspectives on EBHC and on EBHC teaching and learning; and we (3) invited final year students (2013) and 2012 graduates to complete an online survey on EBHC attitudes, self-perceived EBHC competence, and their experience of EBHC teaching and learning...
2017: PloS One
https://www.readbyqxmd.com/read/28206646/acute-melamine-affects-spatial-memory-consolidation-via-inhibiting-hippocampal-nmdar-dependent-ltd-in-rats
#17
Lei An, Wei Sun
No abstract text is available yet for this article.
February 16, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28203657/presence-of-peierls-pairing-and-absence-of-insulator-to-metal-transition-in-vo2-a-a-structure-property-relationship-study
#18
S R Popuri, A Artemenko, R Decourt, A Villesuzanne, M Pollet
Layered vanadium oxides have been extensively explored due to their interesting metal-insulator transitions and energy conversion/storage applications. In the present study, we have successfully synthesized VO2 (A) polymorph powder samples by a single-step hydrothermal synthesis process and consolidated them using spark plasma sintering. The structural and electronic properties of VO2 (A) are measured over a large temperature range from liquid helium, across the structural transition (400-440 K) and up to 500 K...
February 16, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28203515/curvilinear-segmental-mandibular-reconstruction-utilizing-distraction-osteogenesis-and-early-open-callus-manipulation
#19
Alberto Rocha Pereira, Paulo Neves, José Rosa, Scott Bartlett
The authors present a new technique for reconstruction of large curvilinear mandibular defects with distraction osteogenesis and early open callus manipulation. In phase 1, transport disks are created from mandibular bone and distracted across the entire length of the defect, without the restriction from a mandible plate fixation. This allows for full-length distraction until enough regenerate is obtained to reconstruct the defect without the need for additional bone grafts. Taking advantage of the soft moldable regenerate, the second and final operative procedure allows for the manipulation, repositioning, and fixation of the transported segments in the ideal position creating perfect tridimensional form and symmetry of the mandible arch...
January 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28203410/relationship-between-radiologic-patterns-pulmonary-function-values-and-bronchoalveolar-lavage-fluid-cells-in-newly-diagnosed-sarcoidosis
#20
Regina Aleksonienė, Ingrida Zeleckienė, Mindaugas Matačiūnas, Roma Puronaitė, Laimutė Jurgauskienė, Radvilė Malickaitė, Edita Strumilienė, Vygantas Gruslys, Rolandas Zablockis, Edvardas Danila
BACKGROUND: The aim of the present study was to identify specious radiologic and/or physiologic prognostic marker(s), which lead to optimize of the patient follow-up frequency. METHODS: Eighty consecutive patients with newly diagnosed pulmonary sarcoidosis. Patients underwent chest radiography, high-resolution computed tomography (HRCT) examination, pulmonary function tests (PFT), bronchoscopy with bronchoalveolar lavage (BAL) and lung biopsy, and bronchoalveolar lavage fluid (BALF) cell examination...
January 2017: Journal of Thoracic Disease
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