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https://www.readbyqxmd.com/read/29351171/spinal-pkc-erk-signal-pathway-mediates-hyperalgesia-priming
#1
Wei-Hsin Chen, Ya-Ting Chang, Yong-Cyuan Chen, Sin-Jhong Cheng, Chien-Chang Chen
Chronic pain can be initiated by one or more acute stimulations to sensitize neurons into the primed state. In the primed state, the basal nociceptive thresholds of the animal are normal, but in response to another hyperalgesic stimulus, the animal develops enhanced and prolonged hyperalgesia. The exact mechanism of how primed state is formed is not completely understood. Here we showed that spinal PKC/ERK signal pathway is required for neuronal plasticity change, hyperalgesic priming formation and the development of chronic hyperalgesia using acid-induced muscle pain (AIMP) model in mice...
January 18, 2018: Pain
https://www.readbyqxmd.com/read/29348476/animal-models-of-obesity-and-diabetes-mellitus
#2
REVIEW
Maximilian Kleinert, Christoffer Clemmensen, Susanna M Hofmann, Mary C Moore, Simone Renner, Stephen C Woods, Peter Huypens, Johannes Beckers, Martin Hrabe de Angelis, Annette Schürmann, Mostafa Bakhti, Martin Klingenspor, Mark Heiman, Alan D Cherrington, Michael Ristow, Heiko Lickert, Eckhard Wolf, Peter J Havel, Timo D Müller, Matthias H Tschöp
More than one-third of the worldwide population is overweight or obese and therefore at risk of developing type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more potent therapeutics are urgently required. This necessitates the continued use of animal models to discover, validate and optimize novel therapeutics for their safe use in humans. In order to improve the transition from bench to bedside, researchers must not only carefully select the appropriate model but also draw the right conclusions...
January 19, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29347928/chronic-obstructive-pulmonary-disease-guidelines-in-europe-a-look-into-the-future
#3
REVIEW
Marc Miravitlles, Nicolas Roche, João Cardoso, David Halpin, Zaurbek Aisanov, Hannu Kankaanranta, Vladimir Kobližek, Paweł Śliwiński, Leif Bjermer, Michael Tamm, Francesco Blasi, Claus F Vogelmeier
Clinical practice guidelines are ubiquitous and are developed to provide recommendations for the management of many diseases, including chronic obstructive pulmonary disease. The development of these guidelines is burdensome, demanding a significant investment of time and money. In Europe, the majority of countries develop their own national guidelines, despite the potential for overlap or duplication of effort. A concerted effort and consolidation of resources between countries may alleviate the resource-intensity of maintaining individual national guidelines...
January 18, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29347043/scaling-laws-for-the-mechanics-of-loose-and-cohesive-granular-materials-based-on-baxter-s-sticky-hard-spheres
#4
Johan Gaume, Henning Löwe, Shurun Tan, Leung Tsang
We have conducted discrete element simulations (pfc3d) of very loose, cohesive, granular assemblies with initial configurations which are drawn from Baxter's sticky hard sphere (SHS) ensemble. The SHS model is employed as a promising auxiliary means to independently control the coordination number z_{c} of cohesive contacts and particle volume fraction ϕ of the initial states. We focus on discerning the role of z_{c} and ϕ for the elastic modulus, failure strength, and the plastic consolidation line under quasistatic, uniaxial compression...
September 2017: Physical Review. E
https://www.readbyqxmd.com/read/29346635/a-scoping-study-of-frameworks-for-adapting-public-health-evidence-based-interventions
#5
Cam Escoffery, Erin Lebow-Skelley, Hallie Udelson, Elaine A Böing, Richard Wood, Maria E Fernandez, Patricia D Mullen
Evidence-based public health translation of research to practice is essential to improve the public's health. Dissemination and implementation researchers have explored what happens once practitioners adopt evidence-based interventions (EBIs) and have developed models and frameworks to describe the adaptation process. This scoping study identified and summarized adaptation frameworks in published reports and grey literature. We followed the recommended steps of a scoping study: (a) identifying the research question; (b) identifying relevant studies; (c) selecting studies; (d) charting the data; (e) collating, summarizing, and reporting the results; and (f) consulting with experts...
January 16, 2018: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/29346627/severe-and-protracted-sleep-disruptions-in-mouse-model-of-post-traumatic-stress-disorder
#6
Rishi Sharma, Pradeep Sahota, Mahesh M Thakkar
Increasing evidences suggest that the predator threat model is a valid animal model of post-traumatic stress disorder (PTSD). However, sleep has never been examined in this model. Since sleep disturbances, including insomnia and excessive daytime sleepiness, are severe and protracted symptoms of PTSD, we hypothesized that mice exposed to predator odor trauma (POT) will display contextual fear conditioning along with severe and protracted sleep disruptions.Adult male C57BL/6J mice, instrumented with wire electrodes [to record hippocampal field potentials (LFP) and nuchal muscle (EMG) activity], were exposed to contextual conditioning using soiled cat litter as unconditional stimulus (US)...
January 13, 2018: Sleep
https://www.readbyqxmd.com/read/29346582/it-s-not-just-what-you-do-it-s-also-the-way-that-you-do-it-patient-and-public-involvement-in-the-development-of-health-research
#7
Tracey J Devonport, Wendy Nicholls, Lynne H Johnston, Robin Gutteridge, Angela Watt
Purpose: This article presents a reflective account of Patient and Public Involvement (PPI) in the development of obesity and binge eating research. Method: We established Patient Advisory Groups (PAGs) at two English regional National Health Service (NHS) weight management services. PPI was evaluated as follows: (i) PAG members completed a Post Participation Evaluation Questionnaire, (ii) PAG meetings captured group discussion on PPI involvement, (iii) practitioner and researchers produced written reflections on PPI and (iv) sources one to three were consolidated during reflections that took place via e-mail and telephone correspondence between researchers and practitioners, culminating in a summary SKYPE meeting between one practitioner and one researcher involved in the PAGs...
January 16, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29346007/the-rise-and-fall-of-universal-health-coverage-as-a-goal-of-international-health-politics-1925-1952
#8
Martin Gorsky, Christopher Sirrs
The UN Sustainable Development Goals of 2015 have restored universal health coverage (UHC) to prominence in the international health agenda. Can understanding the past illuminate the prospects for UHC in the present? This article traces an earlier history of UHC as an objective of international health politics. Its focus is the efforts of the International Labor Organization (ILO), whose Philadelphia Declaration (1944) announced the goal of universal social security, including medical coverage and care. After World War II, the ILO attempted to enshrine this in an international convention, which nation states would ratify...
January 18, 2018: American Journal of Public Health
https://www.readbyqxmd.com/read/29344622/barriers-to-and-facilitators-of-implementing-enhanced-recovery-pathways-using-an-implementation-framework-a-systematic-review
#9
Alexander B Stone, Christina T Yuan, Michael A Rosen, Michael C Grant, Lauren E Benishek, Elizabeth Hanahan, Lisa H Lubomski, Clifford Ko, Elizabeth C Wick
Importance: Enhanced recovery pathways (ERPs) have the potential to reduce length of hospital stay, costs, and complications following surgery but can be challenging to implement. Objective: To examine the body of literature on ERPs to assess how authors describe barriers and facilitators of ERP implementation and identify, in aggregate, the best practices that should be considered utilizing the Consolidated Framework for Implementation Research (CFIR) to extract these elements and summarize common barriers and facilitators according to its 5 major domains: (1) intervention characteristics, (2) inner setting, (3) outer setting, (4) characteristics of the individuals, and (5) the process of implementation...
January 17, 2018: JAMA Surgery
https://www.readbyqxmd.com/read/29343286/diagnosis-and-management-of-transthyretin-familial-amyloid-polyneuropathy-in-japan-red-flag-symptom-clusters-and-treatment-algorithm
#10
REVIEW
Yoshiki Sekijima, Mitsuharu Ueda, Haruki Koike, Sonoko Misawa, Tomonori Ishii, Yukio Ando
Hereditary ATTR (ATTRm) amyloidosis (also called transthyretin-type familial amyloid polyneuropathy [ATTR-FAP]) is an autosomal-dominant, adult-onset, rare systemic disorder predominantly characterized by irreversible, progressive, and persistent peripheral nerve damage. TTR gene mutations (e.g. replacement of valine with methionine at position 30 [Val30Met (p.Val50Met)]) lead to destabilization and dissociation of TTR tetramers into variant TTR monomers, which form amyloid fibrils that deposit in peripheral nerves and various organs, giving rise to peripheral and autonomic neuropathy and several non-disease specific symptoms...
January 17, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29340439/-origin-of-the-scientific-arguments-underlying-qualitative-research
#11
Maria Cecília de Souza Minayo
This article analyzes the origin of the primary arguments that underpin the qualitative approach, covering the birthplace of comprehensive and dialectical thought in Germany, its expansion into other countries such as France and the United States, and its spread into Latin America. The historical journey of the text starts with the development of modern science, examining the first empirical works in the Chicago School and the subsequent period of ostracism of qualitative research. The text also evidences a revival of comprehensive theoretical and empirical perspectives from the 1960s onwards, accompanying the cultural movement that came to question the great theoretical narratives and give rise to reflections on subjectivity...
October 2017: Salud Colectiva
https://www.readbyqxmd.com/read/29339562/sleep-dependent-reductions-in-reality-monitoring-errors-arise-from-more-conservative-decision-criteria
#12
Carmen E Westerberg, Christopher A Hawkins, Lauren Rendon
Reality-monitoring errors occur when internally generated thoughts are remembered as external occurrences. We hypothesized that sleep-dependent memory consolidation could reduce them by strengthening connections between items and their contexts during an afternoon nap. Participants viewed words and imagined their referents. Pictures of the referents also accompanied half of the words. After a 2-h break filled with sleep (n = 31) or wakefulness (n = 32), participants indicated if they previously viewed a picture of each word...
February 2018: Learning & Memory
https://www.readbyqxmd.com/read/29339558/does-sleep-facilitate-the-consolidation-of-allocentric-or-egocentric-representations-of-implicitly-learned-visual-motor-sequence-learning
#13
Jeremy Viczko, Valya Sergeeva, Laura B Ray, Adrian M Owen, Stuart M Fogel
Sleep facilitates the consolidation (i.e., enhancement) of simple, explicit (i.e., conscious) motor sequence learning (MSL). MSL can be dissociated into egocentric (i.e., motor) or allocentric (i.e., spatial) frames of reference. The consolidation of the allocentric memory representation is sleep-dependent, whereas the egocentric consolidation process is independent of sleep or wake for explicit MSL. However, it remains unclear the extent to which sleep contributes to the consolidation of implicit (i.e., unconscious) MSL, nor is it known what aspects of the memory representation (egocentric, allocentric) are consolidated by sleep...
February 2018: Learning & Memory
https://www.readbyqxmd.com/read/29339533/learning-dependent-chromatin-remodeling-highlights-noncoding-regulatory-regions-linked-to-autism
#14
John N Koberstein, Shane G Poplawski, Mathieu E Wimmer, Giulia Porcari, Charlly Kao, Bruce Gomes, Davide Risso, Hakon Hakonarson, Nancy R Zhang, Robert T Schultz, Ted Abel, Lucia Peixoto
Autism spectrum disorder (ASD) is a prevalent neurodevelopmental disorder that is associated with genetic risk factors. Most human disease-associated single-nucleotide polymorphisms (SNPs) are not located in genes but rather are in regulatory regions that control gene expression. The function of regulatory regions is determined through epigenetic mechanisms. Parallels between the cellular basis of development and the formation of long-term memory have long been recognized, particularly the role of epigenetic mechanisms in both processes...
January 16, 2018: Science Signaling
https://www.readbyqxmd.com/read/29339118/aerobic-and-anaerobic-cellulose-utilization-by-paenibacillus-sp-caa11-and-enhancement-of-its-cellulolytic-ability-by-expressing-a-heterologous-endoglucanase
#15
Eun Sook Kim, Byeong-Soo Kim, Ki-Yeon Kim, Han-Min Woo, Sun-Mi Lee, Youngsoon Um
For cost-effective lignocellulosic biofuel/chemical production, consolidated bioprocessing (CBP)-enabling microorganisms utilizing cellulose as well as producing biofuel/chemical are required. A novel strain Paenibacillus sp. CAA11 isolated from sediment was found to be not only as a cellulose degrader under both aerobic and strict anaerobic conditions but also as a producer of cellulosic biofuel/chemicals. Paenibacillus sp. CAA11 secreted cellulolytic enzymes by its own secretion system and produced ethanol as well as short-chain organic acids (formic acid, acetic acid, lactic acid) from cellulose...
January 12, 2018: Journal of Biotechnology
https://www.readbyqxmd.com/read/29338624/use-of-service-learning-to-increase-master-s-level-nursing-students-understanding-of-social-determinants-of-health-and-health-disparities
#16
Keneshia Bryant-Moore, Ashley Bachelder, Larronda Rainey, Kimberly Hayman, Alexa Bessette, Candace Williams
INTRODUCTION: It is important for graduate-level nursing students to be competent in the issues involved in the social determinants of health and health disparities and have the tools to address them as graduates. METHOD: As part of a nursing workforce diversity program, master's-level nursing students were required to participate in a service learning project exposing them to an issue not directly linked to health-long bus rides for students as a result of school consolidations-to achieve educational goals and objectives while providing a service to an advocacy agency...
January 1, 2018: Journal of Transcultural Nursing: Official Journal of the Transcultural Nursing Society
https://www.readbyqxmd.com/read/29338491/the-effect-of-ketamine-on-the-consolidation-and-extinction-of-contextual-fear-memory
#17
Nicholas E Clifton, Kerrie L Thomas, Jeremy Hall
Ketamine, principally an antagonist of N-methyl-ᴅ-aspartate receptors, induces schizophrenia-like symptoms in adult humans, warranting its use in the investigation of psychosis-related phenotypes in animal models. Genomic studies further implicate N-methyl-ᴅ-aspartate receptor-mediated processes in schizophrenia pathology, together with more broadly-defined synaptic plasticity and associative learning processes. Strong pathophysiological links have been demonstrated between fear learning and psychiatric disorders such as schizophrenia...
January 1, 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29337314/the-reconstruction-of-2-631-draft-metagenome-assembled-genomes-from-the-global-oceans
#18
Benjamin J Tully, Elaina D Graham, John F Heidelberg
Microorganisms play a crucial role in mediating global biogeochemical cycles in the marine environment. By reconstructing the genomes of environmental organisms through metagenomics, researchers are able to study the metabolic potential of Bacteria and Archaea that are resistant to isolation in the laboratory. Utilizing the large metagenomic dataset generated from 234 samples collected during the Tara Oceans circumnavigation expedition, we were able to assemble 102 billion paired-end reads into 562 million contigs, which in turn were co-assembled and consolidated in to 7...
January 16, 2018: Scientific Data
https://www.readbyqxmd.com/read/29336635/lymphomatoid-granulomatosis-in-a-14-year-old-boy-with-trisomy-21-and-history-of-b-lymphoblastic-leukemia-lymphoma
#19
Anna Paulina Matynia, Sherrie L Perkins, David Li
BACKGROUND: Lymphomatoid granulomatosis is a EBV-driven lymphoproliferative disorder that has been reported in association with immunodeficiency, but only exceptionally in patients with hematopoietic malignancy. CASE REPORT: A 14-year-old boy with trisomy-21 and a history of B-lymphoblastic leukemia/lymphoma (B-ALL) diagnosed 1.5 years prior, on maintenance chemotherapy, presented with fever and respiratory symptoms. Chest X-ray revealed right-lower-lobe consolidation...
January 16, 2018: Fetal and Pediatric Pathology
https://www.readbyqxmd.com/read/29336465/breast-cancer-stem-like-cells-are-sensitized-to-tamoxifen-induction-of-self-renewal-inhibition-with-enforced-let-7c-dependent-on-wnt-blocking
#20
Xin Sun, Chongwen Xu, Guodong Xiao, Jinying Meng, Jichang Wang, Shou-Ching Tang, Sida Qin, Ning Du, Gang Li, Hong Ren, Dapeng Liu
Let-7 microRNAs have been reported to have tumor suppressive functions; however, the effect of Let-7 when used in combination with chemotherapies is uncertain, but may have potential for use in clinical practice. In this study, we used RT-qPCR, western blot analysis, cell proliferation assay, flow cytometry analysis, immunohistochemistry (IHC) staining, luciferase assays, cell sorting analysis and xenografted tumor model to explore the role of Let-7 in the chemotherapy sensitivity of breast cancer stem cells...
January 15, 2018: International Journal of Molecular Medicine
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