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https://www.readbyqxmd.com/read/29775992/from-breaking-point-to-breakthrough-during-the-icu-stay-a-qualitative-study-of-family-members-experiences-of-long-term-intensive-care-patients-pathways-towards-survival
#1
Hege S Haugdahl, Regina Eide, Ingeborg Alexandersen, Tove Engan Paulsby, Berit Stjern, Stine Borgen Lund, Gørill Haugan
AIMS AND OBJECTIVES: To explore family members' experiences of long-term intensive care unit (ICU) patients' pathways towards survival and to highlight family members' efforts to promote the patient's health during the ICU stay. BACKGROUND: Although considerable research has been devoted to the substantial burden of long-term ICU patients, less attention has been paid to health promoting factors that facilitate patients' health and survival during ICU stays. Support from family members can improve patient outcome...
May 18, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29775731/targeted-and-controlled-drug-delivery-by-multifunctional-mesoporous-silica-nanoparticles-with-internal-fluorescent-conjugates-and-external-polydopamine-and-graphene-oxide-layers
#2
Anh-Vy Tran, KyuHwan Shim, Thu-Thao Vo Thi, Jeong-Keun Kook, Seong Soo A An, Sang-Wha Lee
This study demonstrated the targeted delivery and controlled release of cisplatin drug molecules from doubly decorated mesoporous silica nanoparticles (MSNs), which were internally grafted with fluorescent conjugates and externally coated with polydopamine (PDA) and graphene oxide (GO) layers. The brush-like internal conjugates conferred fluorescent functionality and high capacity of cisplatin loading into MSNs, as well as contributing to a sustained release of the cisplatin through a porous channel with the assistance of external PDA layer...
May 15, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29775405/the-mouse-heart-attack-research-tool-mhart-1-0-database
#3
Kristine Y DeLeon-Pennell, Rugmani Padmanabhan Iyer, Yonggang Ma, Andriy Yabluchanskiy, Rogelio Zamilpa, Ying Ann Chiao, Presley Cannon, Courtney Cates, Elizabeth R Flynn, Ganesh V Halade, Lisandra E de Castro Bras, Merry L Lindsey
The generation of Big Data has enabled systems-level dissections into the mechanisms of cardiovascular pathology. Integration of genetic, proteomic, and pathophysiological variables across platforms and laboratories fosters discoveries through multidisciplinary investigations and minimizes unnecessary redundancy in research efforts. The Mouse Heart Attack Research Tool (mHART) consolidates a large dataset of over 10 years of experiments from a single laboratory for cardiovascular investigators to generate novel hypotheses and identify new predictive markers of progressive left ventricular remodeling following myocardial infarction (MI) in mice...
May 18, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29775118/blood-flow-restricted-resistance-training-in-patients-with-sporadic-inclusion-body-myositis-a-randomized-controlled-trial
#4
A N Jørgensen, P Aagaard, U Frandsen, E Boyle, L P Diederichsen
OBJECTIVES: To investigate the effect of 12 weeks of low-load blood-flow restricted resistance (BFR) training on self-reported and objective physical function, and maximal muscle strength in patients with sporadic inclusion body myositis (sIBM). METHOD: Twenty-two patients with sIBM were randomized into a training group (BFR group) or a non-exercising control group, according to CONsolidated Standards Of Reporting Trials (CONSORT) guidelines. The BFR group performed 12 weeks of BFR training twice per week...
May 18, 2018: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/29774957/progress-and-challenges-in-consolidating-the-management-of-amazonian-protected-areas-and-indigenous-territories
#5
Raymond E Gullison, Jared Hardner
Achieving the effective management of all existing protected areas and indigenous territories in the Amazon Biome may be needed to avoid a deforestation "tipping point" beyond which regional climatic feedbacks and global climate change interact to catalyze irreversible drying and savannization of large portions of the biome. However, the time and money required to consolidate the effective management of all types of protected sites in the Amazon is still poorly understood. At present, protected areas and indigenous territories cover 45...
May 18, 2018: Conservation Biology: the Journal of the Society for Conservation Biology
https://www.readbyqxmd.com/read/29772766/in-situ-synthesis-of-al-based-mmcs-reinforced-with-aln-by-mechanical-alloying-under-nh%C3%A2-gas
#6
E S Caballero, F G Cuevas, F Ternero, R Astacio, J M Montes, J Cintas
Aluminum matrix composites (AMCs) reinforced by aluminum nitride were prepared by mechanical alloying followed by a simple press and sintering method. Milling began under vacuum and after a period of between 1 and 4 h, NH₃ gas flow (1 cm³/s) was incorporated until the total milling time of 5 h was reached. Results show that in addition to the strain hardening taking place during mechanical alloying, NH₃ plays an additional role in powder hardening. Thereby, the properties of the sintered compacts are strongly influenced by the amount of N incorporated into the powders during milling and the subsequent formation of AlN during the consolidation process...
May 17, 2018: Materials
https://www.readbyqxmd.com/read/29772229/polybacterial-community-analysis-in-human-conjunctiva-through-16s-rrna-gene-libraries
#7
Deepthi KrishnanNair Geetha, Jayasudha Rajagopalaboopathi, Girish Rameshan Nair, Manikandan Palanisamy, Ram Rammohan, Narendran Venkatapathy, Prabagaran Solai Ramatchandirane
The conjunctival sac of healthy human harbours a variety of microorganisms. When the eye is compromised, an occasional inadvertent spread happens to the adjacent tissue, resulting in bacterial ocular infections. Microbiological investigation of the conjunctival swab is one of the broadly used modality to study the aetiological agent of conjunctiva. However, most of the time such methods yield unsatisfactory results. Hence, the present study intends to identify the bacterial community in human conjunctiva of pre-operative subjects through 16S rRNA gene libraries...
May 14, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29772202/rnp-granule-assembly-via-ataxin-2-disordered-domains-is-required-for-long-term-memory-and-neurodegeneration
#8
Baskar Bakthavachalu, Joern Huelsmeier, Indulekha P Sudhakaran, Jens Hillebrand, Amanjot Singh, Arnas Petrauskas, Devasena Thiagarajan, M Sankaranarayanan, Laura Mizoue, Eric N Anderson, Udai Bhan Pandey, Eric Ross, K VijayRaghavan, Roy Parker, Mani Ramaswami
Human Ataxin-2 is implicated in the cause and progression of amyotrophic lateral sclerosis (ALS) and type 2 spinocerebellar ataxia (SCA-2). In Drosophila, a conserved atx2 gene is essential for animal survival as well as for normal RNP-granule assembly, translational control, and long-term habituation. Like its human homolog, Drosophila Ataxin-2 (Atx2) contains polyQ repeats and additional intrinsically disordered regions (IDRs). We demonstrate that Atx2 IDRs, which are capable of mediating liquid-liquid phase transitions in vitro, are essential for efficient formation of neuronal mRNP assemblies in vivo...
May 16, 2018: Neuron
https://www.readbyqxmd.com/read/29771839/application-of-autologous-human-bone-marrow-derived-mesenchymal-stem-cells-in-distraction-osteogenesis-for-the-treatment-of-bilateral-mandibular-hypoplasia
#9
Hun Jun Lim, Eui Mook Lee, Won Ki Kim, Han Jong Kim, Bong Chul Kim, Jun Lee
Distraction osteogenesis a surgical procedure conducted to improve craniofacial deformities. Compared with conventional operations, this technique has advantages such as the ability to lengthen the soft tissue and hard tissue. Therefore, this method is used to treat severe craniofacial abnormalities.The major disadvantage of distraction osteogenesis is the long treatment period. If the consolidation period is not sufficiently long after the distraction period, complications such as discontinuity or contraction of newly formed bone may occur...
May 15, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29771774/bronchoscopic-laser-interstitial-thermal-therapy-an-experimental-study-in-normal-porcine-lung-parenchyma
#10
Roberto F Casal, Garrett Walsh, Mark McArthur, Lori R Hill, Maria F Landaeta, Aristides J Armas Villalba, Philip Ong, Labib Debiane, Erik Vakil, Horiana B Grosu, Carlos A Jimenez, David Ost, Roberto Adachi, George A Eapen
BACKGROUND: Population aging and lung cancer screening strategies may lead to an increase in detection of early-stage lung cancer in medical inoperable patients. Recent advances in peripheral bronchoscopy have made it a suitable platform for ablation of small peripheral tumors. METHODS: We investigated the tissue-ablative effect of a diode laser bronchoscopically applied by a laser delivery fiber (LDF) with wide aperture on porcine lung parenchyma. Laser was tested ex vivo and in vivo to identify the most effective power settings and LDF...
May 16, 2018: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/29771695/scheduling-the-nonoperating-room-anesthesia-suite
#11
Mary E Warner, David P Martin
PURPOSE OF REVIEW: Nonoperating room anesthesia (NORA) and procedural services often are associated with dispersed geographic settings and small volumes of cases. These lead to scheduling challenges that, if not managed well, result in decreased patient and healthcare team satisfaction and reduced efficiency. This review describes recent studies and provides examples on how NORA scheduling issues have been addressed. RECENT FINDINGS: Increased use of blocked time for consolidated NORA services can lead to sufficiently large volumes of cases that allow improved scheduling and maintain patient and healthcare team satisfaction and better efficiency of care...
May 15, 2018: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/29771362/rates-of-cerebral-protein-synthesis-in-primary-visual-cortex-during-sleep-dependent-memory-consolidation-a-study-in-human-subjects
#12
Dante Picchioni, Kathleen C Schmidt, Kelly K McWhirter, Inna Loutaev, Adriana J Pavletic, Andrew M Speer, Alan J Zametkin, Ning Miao, Shrinivas Bishu, Kate M Turetsky, Anne S Morrow, Jeffrey L Nadel, Brittney C Evans, Diana M Vesselinovitch, Carrie A Sheeler, Thomas J Balkin, Carolyn B Smith
If protein synthesis during sleep is required for sleep-dependent memory consolidation, we might expect rates of cerebral protein synthesis (rCPS) to increase during sleep in the local brain circuits that support performance on a particular task following training on that task. To measure circuit-specific brain protein synthesis during a daytime nap opportunity, we used the L-[1-(11)C]leucine positron emission tomography (PET) method with simultaneous polysomnography. We trained subjects on the visual texture discrimination task (TDT)...
May 15, 2018: Sleep
https://www.readbyqxmd.com/read/29770804/publication-trends-in-spine-research-from-2007-to-2016-comparison-of-the-orthopaedic-research-society-spine-section-and-the-international-society-for-the-study-of-the-lumbar-spine
#13
John T Martin, Sarah E Gullbrand, Aaron J Fields, Devina Purmessur, Ashish D Diwan, Thomas R Oxland, Kazuhiro Chiba, Farshid Guilak, Judith A Hoyland, James C Iatridis
This study investigated current trends in spine publications of the membership of Orthopaedic Research Society Spine Section (ORS3) and the more global and clinically focused International Society for the Study of the Lumbar Spine (ISSLS). The PubMed database was probed to quantify trends in the overall number of articles published, the number of journals these articles were published in, and the number of active scientists producing new manuscripts. We also evaluated trends in flagship spine journals ( Spine , European Spine Journal , and The Spine Journal ) and in the Journal of Orthopaedic Research...
March 2018: JOR spine
https://www.readbyqxmd.com/read/29770791/effects-of-laparoscopic-and-conventional-methods-on-lung-functions-in-colorectal-surgery
#14
Sebahattin Celik, Eyüp M Yılmaz
BACKGROUND We aimed to compare the lung functions, complication rates, and durations of the hospital and intensive care unit stays of patients who had undergone laparoscopic colorectal resection and open colorectal resection. MATERIAL AND METHODS In this study, data were collected prospectively and then evaluated retrospectively. The study was carried out between January 2015 and November 2016 in 2 university hospitals. Pulmonary function tests (PFT) and chest radiography were performed in all patients preoperatively...
May 17, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29770586/surgical-infection-after-posterolateral-lumbar-spine-arthrodesis-ct-analysis-of-spinal-fusion
#15
Pablo Andrés-Cano, Ana Cerván, Miguel Rodríguez-Solera, Jose Antonio Ortega, Natividad Rebollo, Enrique Guerado
OBJECTIVE: To determine the incidence of infection after instrumented lumbar spine surgery, the demographic and surgical variables associated with acute infection, and the influence of infection and debridement on the consolidation of spinal fusion. METHODS: After obtaining approval from the hospital ethics committee, an observational study was made on a prospective cohort of consecutive patients surgically treated by posterolateral lumbar spine arthrodesis (n = 139, 2005-2011)...
May 16, 2018: Orthopaedic Surgery
https://www.readbyqxmd.com/read/29769080/a-complex-culturally-targeted-intervention-to-reduce-hispanic-disparities-in-living-kidney-donor-transplantation-an-effectiveness-implementation-hybrid-study-protocol
#16
Elisa J Gordon, Jungwha Lee, Raymond H Kang, Juan Carlos Caicedo, Jane L Holl, Daniela P Ladner, Michelle D Shumate
BACKGROUND: The shortage of organs for kidney transplantation for patients with end-stage renal disease (ESRD) is magnified in Hispanics/Latin Americans in the United States. Living donor kidney transplantation (LDKT) is the treatment of choice for ESRD. However, compared to their representation on the transplant waitlist, fewer Hispanics receive a LDKT than non-Hispanic whites. Barriers to LDKT for Hispanics include: lack of knowledge, cultural concerns, and language barriers. Few interventions have been designed to reduce LDKT disparities...
May 16, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29768934/a-safety-profile-of-medications-used-to-treat-waldenstr%C3%A3-m-s-macroglobulinemia
#17
Ramón García-Sanz, Cristina Jiménez, Verónica González de la Calle, María Eugenia Sarasquete
Waldenström's macroglobulinemia (WM) is a B-cell lymphoproliferative disease with serum IgM monoclonal component and bone marrow infiltration by lymphoplasmacytic lymphoma. Traditional therapy was based on that regimens used for closely related entities, such as chronic lymphocytic leukemia or multiple myeloma. This resulted in a lack of drugs specifically approved for WM, until the discovery of the BTK inhibitors. Areas covered. Two main therapeutic attitudes are possible: 1) conventional therapies based on combinations with alkylating agents or proteasome inhibitors with steroids and anti-CD20 monoclonal antibodies, or; 2) new approaches with BTK inhibitors, usually alone...
May 17, 2018: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/29768834/clay-nanoarchitectures-as-photocatalysts-by-in-situ-assembly-of-zno-nanoparticles-and-clay-minerals
#18
M Akkari, P Aranda, A Ben Haj Amara, E Ruiz-Hitzky
ZnO-clay nanoarchitectures have been prepared by In Situ generation of ZnO nanoparticles from zinc acetylacetonate in isopropanol under reflux in the presence of organoclays. Two layered clays, a commercial Wyoming montmorillonite and a smectite from Gafsa (Tunisia), and a fibrous clay, sepiolite from Vallecas-Vicalvaro (Spain), modified with cetyltrimethylammonium ions were the organoclay substrates for assembling the formed nanoparticles. After a convenient thermal treatment, the organic matter is eliminated and the ZnO/clay nanoarchitectures consolidated...
January 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29768201/activation-of-ephb2-forward-signaling-enhances-memory-consolidation
#19
Jessica M Alapin, Monica Dines, Maria Vassiliev, Tal Tamir, Alon Ram, Clifford Locke, Ji Yu, Raphael Lamprecht
EphB2 is involved in enhancing synaptic transmission and gene expression. To explore the roles of EphB2 in memory formation and enhancement, we used a photoactivatable EphB2 (optoEphB2) to activate EphB2 forward signaling in pyramidal neurons in lateral amygdala (LA). Photoactivation of optoEphB2 during fear conditioning, but not minutes afterward, enhanced long-term, but not short-term, auditory fear conditioning. Photoactivation of optoEphB2 during fear conditioning led to activation of the cAMP/Ca2+ responsive element binding (CREB) protein...
May 15, 2018: Cell Reports
https://www.readbyqxmd.com/read/29765744/spontaneous-resolution-and-crystal-structure-of-2-s-2-3-nitro-phen-yl-3-phenyl-2-3-5-6-tetra-hydro-4-h-1-3-thia-zin-4-one-crystal-structure-of-rac-2-4-nitro-phen-yl-3-phenyl-2-3-5-6-tetra-hydro-4-h-1-3-thia-zin-4-one
#20
Hemant P Yennawar, Heather G Bradley, Kristen C Perhonitch, Haley E Reppert, Lee J Silverberg
The crystal structures of isomeric rac -2-(4-nitro-phen-yl)-3-phenyl-2,3,5,6-tetra-hydro-4 H -1,3-thia-zin-4-one (C16 H14 N2 O3 S) ( 1 ) and (2 S )-2-(3-nitro-phen-yl)-3-phenyl-2,3,5,6-tetra-hydro-4 H -1,3-thia-zin-4-one (C16 H14 N2 O3 S) ( 2 ) are reported here. While 1 crystallizes in a centrosymmetric space group, the crystal of 2 chosen for data collection has mol-ecules only with (2 S ) chirality. This is the result of spontaneous resolution during crystallization, as the synthesis produces a racemic mixture...
April 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
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