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Infant <90 days

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https://www.readbyqxmd.com/read/28906495/effects-of-a-transition-home-program-on-preterm-infant-emergency-room-visits-within-90-days-of-discharge
#1
B Vohr, E McGowan, L Keszler, M O'Donnell, K Hawes, R Tucker
OBJECTIVE: To evaluate effects of a transition home program (THP) and risk factors on emergency room (ER) use within 90 days of discharge for preterm (PT) infants <37 weeks gestation. STUDY DESIGN: This is a prospective 3-year cohort study of 804 mothers and 954 PT infants. Mothers received enhanced neonatal intensive care unit transition support services until 90 days postdischarge. Regression models were run to identify the effects of THP implementation year and risk factors on ER visits...
September 14, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28901944/vitamin-d-deficiency-in-pregnant-women-and-their-infants
#2
Abdurrahman Avar Özdemir, Yasemin Ercan Gündemir, Mustafa Küçük, Deniz Yıldıran Sarıca, Yusuf Elgörmüş, Yakup Çağ, Günal Bilek
OBJECTIVE: Vitamin D deficiency is a serious health problem although the improvement in socio-economic status in Turkey. The aim of this study was to evaluate the maternal vitamin D status and their effect on neonatal vitamin D status after support program for pregnant women and to detect risk factors for vitamin D deficiency in Bağcılar region in İstanbul. METHODS: A total of 97 pregnant women and 90 infants were included in this study between January and October 2016...
September 13, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28899472/-long-term-effect-of-oligodendrocyte-precursor-cell-transplantation-on-a-rat-model-of-white-matter-injury-in-the-preterm-infant
#3
Cheng-Jun Wu, Zhao-Yan Wang, Yin-Xiang Yang, Zuo Luan
OBJECTIVE: To investigate the long-term effect of oligodendrocyte precursor cell (OPC) transplantation on a rat model of white matter injury (WMI) in the preterm infant. METHODS: A total of 80 Sprague-Dawley rats aged 3 days were randomly divided into sham-operation group, model control group, 5-day ventricular/white matter transplantation group, 9-day ventricular/white matter transplantation group, 14-day ventricular/white matter transplantation group (n=10 each)...
September 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28894126/microbes-in-infant-gut-development-placing-abundance-within-environmental-clinical-and-growth-parameters
#4
Tanja Obermajer, Iztok Grabnar, Evgen Benedik, Tina Tušar, Tatjana Robič Pikel, Nataša Fidler Mis, Bojana Bogovič Matijašić, Irena Rogelj
Sound and timely microbial gut colonization completes newborn's healthy metabolic programming and manifests in infant appropriate growth and weight development. Feces, collected at 3, 30, and 90 days after birth from 60 breastfed Slovenian newborns, was submitted to microbial DNA extraction and qPCR quantification of selected gut associated taxa. Multivariate regression analysis was applied to evaluate microbial dynamics with respect to infant demographic, environmental, clinical characteristics and first year growth data...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28891004/cerebral-imaging-and-neurodevelopmental-outcome-after-entero-and-human-parechovirus-sepsis-in-young-infants
#5
Eveline P de Jong, Herma C Holscher, Sylke J Steggerda, Jeanine M M Van Klink, Erika P M van Elzakker, Enrico Lopriore, Frans J Walther, Frank Brus
Enterovirus (EV) and human parechovirus (HPeV) are major causes of sepsis-like illness in infants under 90 days of age and have been identified as neurotropic. Studies about acute and long-term neurodevelopment in infants with sepsis-like illness without the need for intensive care are few. This study investigates cerebral imaging and neurodevelopmental outcome following EV and HPeV infection in these infants. We studied infants under 90 days of age who were admitted to a medium care unit with proven EV- or HPeV-induced sepsis-like illness...
September 10, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28888967/twenty-five-gauge-sutureless-lensectomy-in-infants-with-congenital-cataract
#6
Marcia Beatriz Tartarella, João Borges Fortes Filho
PURPOSE: To evaluate the incidence of intra- and postoperative complications of transconjunctival 25-gauge (25G) sutureless pars plicata lensectomy. METHODS: The medical records of patients <12 months of age with congenital cataracts who underwent 25G sutureless lensectomy were reviewed retrospectively. Patients were evaluated at postoperative days 1, 7, 15, 30, 60, and 90 and every 3 months thereafter. Visual acuity outcomes and intra- and postoperative complications were described and analyzed...
September 6, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28885390/epidemiology-of-admissions-from-the-emergency-department-among-febrile-infants-younger-than-90-days-in-the-united-states-2002-to-2012
#7
Diana K Nguyen, Ross J Fleischman, Scott Friedlander, Kenneth M Zangwill
BACKGROUND AND OBJECTIVES: Febrile infants younger than 90 days are often subjected to invasive diagnostic evaluation and hospitalization to monitor for serious bacterial infection (SBI) despite recent changes in SBI risk and advances in diagnostics. Nationwide provider practices, over time, are unknown for this group. Our objective was to determine the likelihood of admission and associated complications of care for such infants, particularly those at lowest risk for SBI. METHODS: This is a retrospective cohort study including multisite emergency department (ED) visits using administrative data from the Pediatric Emergency Care Applied Research Network Core Data Project...
September 5, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28884229/time-to-event-analysis-of-surgically-treated-posthemorrhagic-hydrocephalus-in-preterm-infants-a-single-institution-retrospective-study
#8
Rowland H Han, Daniel Berger, Mohamed Gabir, Brandon S Baksh, Diego M Morales, Amit M Mathur, Christopher D Smyser, Jennifer M Strahle, David D Limbrick
PURPOSE: The purpose of this study is to report time points relevant to the neurosurgical management of posthemorrhagic hydrocephalus (PHH). METHODS: Data were collected retrospectively on 104 preterm infants with intraventricular hemorrhage (IVH) who received neurosurgical intervention for PHH at St. Louis Children's Hospital from 1994 to 2016. Kaplan-Meier curves were constructed for various endpoints. RESULTS: IVH grade on head ultrasound obtained through routine clinical care was II, III, and IV in 5 (4...
September 7, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28880379/red-blood-cell-alloimmunization-in-neonates-and-children-up-to-3-years-of-age
#9
Tugce Türkmen, Dan Qiu, Nina Cooper, Ulrich J Sachs, Wilhelm Wößmann, Dietmar Schranz, Klaus-Peter Zimmer, Harald Ehrhardt, Holger Hackstein, Gregor Bein
BACKGROUND: An alloimmune response to red blood cell (RBC) transfusion in neonates is a rare event. Several guidelines recommend limited pretransfusion testing in neonates. The evidence for these recommendations is based on small studies with sample sizes of between 30 and 90 infants. STUDY DESIGN AND METHODS: We conducted a retrospective cohort study among consecutive patients who received transfusions at a single university medical center. All non-alloimmunized patients who had received their first RBC transfusion between 1994 and 2013 and who underwent at least one antibody screening follow-up visit between 7 and 365 days after transfusion were included...
September 6, 2017: Transfusion
https://www.readbyqxmd.com/read/28875061/impact-of-caffeine-boluses-and-caffeine-discontinuation-on-apnea-and-hypoxemia-in-preterm-infants
#10
Christa R Tabacaru, Suk Young Jang, Manisha Patel, Faranek Davalian, Santina Zanelli, Karen D Fairchild
Background: Apnea of prematurity often occurs during and following caffeine therapy. We hypothesized that number of apnea events would be impacted by adjustments in caffeine therapy. Materials and Methods: An automated algorithm was used in all infants ≤32 weeks gestation admitted to a level IV Neonatal Intensive Care Unit from 2009 to 2014 to analyze chest impedance, electrocardiogram, and oxygen saturation data around the time of serum caffeine levels, caffeine boluses while on maintenance therapy, and caffeine discontinuation...
September 1, 2017: Journal of Caffeine Research
https://www.readbyqxmd.com/read/28873292/dose-exposure-simulation-for-piperacillin-tazobactam-dosing-strategies-in-infants-and-young-children
#11
Céline Thibault, Nastya Kassir, Yves Théorêt, France Varin, Catherine Litalien, Julie Autmizguine
BACKGROUND: Extended piperacillin-tazobactam (TZP) infusions have been associated with favourable outcomes. There are currently no pediatric dosing recommendations. OBJECTIVES: To determine appropriate TZP dosing strategies in children 2 months - 6 years according to age and different minimal inhibitory concentrations (MICs). METHODS: Age and weight were simulated for 1000 children. Post-hoc pharmacokinetic parameter estimates were generated using published clearance and volume of distribution data...
August 21, 2017: Journal of Population Therapeutics and Clinical Pharmacology
https://www.readbyqxmd.com/read/28871598/introducing-universal-ultrasound-screening-for-developmental-dysplasia-of-the-hip-doubled-the-treatment-rate
#12
Stine Feiring Olsen, Hans Christian Blom, Karen Rosendahl
AIM: There is no evidence on the effect of universal ultrasound screening on developmental dysplasia of the hip. We examined the impact of adding an ultrasound examination to a one examiner clinical screening strategy on treatment, follow-up rates and the number of cases detected late in a low-prevalence population. METHODS: All eligible babies born at Kongsberg Hospital, Norway, from 1998-2006 (n=4,245) underwent both clinical and ultrasound hip examinations within three days of life...
September 4, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28859083/short-term-effectiveness-of-a-community-health-worker-intervention-for-hiv-infected-pregnant-women-in-tanzania-to-improve-treatment-adherence-and-retention-in-care-a-cluster-randomized-trial
#13
Nerissa Nance, Prosper Pendo, Joseph Masanja, David Paul Ngilangwa, Karen Webb, Rita Noronha, Sandra I McCoy
INTRODUCTION: Community health workers (CHWs) are lay workers who have the potential to enhance services to prevent mother-to-child HIV transmission (PMTCT) and improve the health of women living with HIV infection. We conducted a cluster-randomized trial of an intervention to integrate CHWs with 'Option B+' PMTCT services in Shinyanga Region, Tanzania. METHODS: The intervention was implemented for 11 months and included four integrated components: 1) formal linkage of CHWs to health facilities; 2) CHW-led antiretroviral therapy (ART) adherence counseling; 3) loss to follow-up tracing by CHWs; and 4) distribution of Action Birth Cards (ABCs), a birth planning tool...
2017: PloS One
https://www.readbyqxmd.com/read/28836266/late-%C3%A2-7-days-inhalation-corticosteroids-to-reduce-bronchopulmonary-dysplasia-in-preterm-infants
#14
REVIEW
Wes Onland, Martin Offringa, Anton van Kaam
BACKGROUND: Bronchopulmonary dysplasia (BPD), defined as oxygen dependence at 36 weeks postmenstrual age (PMA), remains an important complication of prematurity. Pulmonary inflammation plays a central role in the pathogenesis of BPD. Attenuating pulmonary inflammation with postnatal systemic corticosteroids reduces the incidence of BPD in preterm infants but may be associated with an increased risk of adverse neurodevelopmental outcomes. Local administration of corticosteroids via inhalation might be an effective and safe alternative...
August 24, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28827241/assessment-of-healthcare-delivery-in-the-early-management-of-bacterial-meningitis-in-uk-young-infants-an-observational-study
#15
Ifeanyichukwu O Okike, Shamez N Ladhani, Mark Anthony, Nelly Ninis, Paul T Heath
OBJECTIVE: To define early presenting features of bacterial meningitis in young infants in England and to review the adequacy of individual case management as compared with relevant national guidelines and an expert panel review. DESIGN: Retrospective medical case note review and parental recall using standardised questionnaires. SETTING: England and Wales. PARTICIPANTS: Infants aged <90 days with bacterial meningitis diagnosed between July 2010 and July 2013...
August 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28815293/the-novel-preventive-effect-of-daikenchuto-tj-100-a-japanese-herbal-drug-against-neonatal-necrotizing-enterocolitis-in-rats
#16
Shin Shinyama, Tatsuru Kaji, Motoi Mukai, Kazuhiko Nakame, Hiroshi Matsufuji, Hideo Takamatsu, Satoshi Ieiri
PURPOSE: Necrotizing enterocolitis (NEC) is a devastating gastrointestinal disease of premature infants. Daikenchuto, a Japanese herbal drug, has several effects on the digestive system, so we investigated its preventive effects in a rat model of NEC. METHODS: NEC was induced in newborn rats via asphyxia (100% N2 for 90 s; every 4 h) + LPS (4 mg/kg/day [administered orally on days 0 and 1]). The effects of Daikenchuto were evaluated in four groups (control: 0 g/kg/day, I: 0...
August 16, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/28814616/the-yale-observation-scale-score-and-the-risk-of-serious-bacterial-infections-in-febrile-infants
#17
Lise E Nigrovic, Prashant V Mahajan, Stephen M Blumberg, Lorin R Browne, James G Linakis, Richard M Ruddy, Jonathan E Bennett, Alexander J Rogers, Leah Tzimenatos, Elizabeth C Powell, Elizabeth R Alpern, T Charles Casper, Octavio Ramilo, Nathan Kuppermann
OBJECTIVES: To assess the performance of the Yale Observation Scale (YOS) score and unstructured clinician suspicion to identify febrile infants ≤60 days of age with and without serious bacterial infections (SBIs). METHODS: We performed a planned secondary analysis of a prospective cohort of non-critically ill, febrile, full-term infants ≤60 days of age presenting to 1 of 26 participating emergency departments in the Pediatric Emergency Care Applied Research Network...
June 6, 2017: Pediatrics
https://www.readbyqxmd.com/read/28814255/current-evidence-on-the-evaluation-and-management-of-fever-without-a-source-in-infants-aged-0-90-days-a-review
#18
Joyee G Vachani, Kenya McNeal-Trice, Sowdhamini S Wallace
BACKGROUND: Despite development of risk stratification tools decades ago, the best strategy for evaluation and management of young infants with fever without a clear source remains uncertain. OBJECTIVE: To describe the variability in current practice and review recently published evidence in three key areas: inflammatory markers as a tool for risk stratification, impact of viral testing, and optimal observation time on antibiotics. METHODS: Articles were identified using PubMed, Scopus, and Cochrane databases and via experts...
August 16, 2017: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/28799220/c-reactive-protein-concentrations-can-help-to-determine-which-febrile-infants-under-three-months-should-receive-blood-cultures-during-influenza-seasons
#19
Weiran Li, Shuanghong Luo, Yu Zhu, Yang Wen, Min Shu, Chaomin Wan
AIM: We explored whether C-reactive protein (CRP) concentrations could indicate which infants with fever without source (FWS) should receive undergo blood culture tests during influenza seasons. METHODS: This retrospective study focused on patients under three months of age with FWS who had received blood culture tests at the West China Second University Hospital Paediatric Emergency Department during the influenza seasons from June 2013 to January 2015. The statistical analysis comprised: specificity, sensitivity, multilevel likelihood ratios, receiver operating characteristic analysis and a multivariate logistic regression model...
August 11, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28796856/detection-of-potentially-severe-retinopathy-of-prematurity-by-remote-image-grading
#20
Graham E Quinn, Gui-Shuang Ying, Wei Pan, Agnieshka Baumritter, Ebenezer Daniel
Importance: Telemedicine in retinopathy of prematurity (ROP) has the potential for delivering timely care to premature infants at risk for serious ROP. Objective: To describe the characteristics of eyes at risk for ROP to provide insights into what types of ROP are most easily detected early by image grading. Design, Setting, and Participants: Secondary analysis of eyes with referral-warranted (RW) ROP (stage 3 ROP, zone I ROP, plus disease) on diagnostic examination from the Telemedicine Approaches to Evaluating Acute-Phase Retinopathy of Prematurity (e-ROP) study was conducted from May 1, 2011, to October 31, 2013, in 1257 premature infants with birth weights less than 1251 g in 13 neonatal units in North America...
September 1, 2017: JAMA Ophthalmology
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