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Parechovirus

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https://www.readbyqxmd.com/read/28081453/intertypic-recombination-of-human-parechovirus-4-isolated-from-infants-with-sepsis-like-disease
#1
Pekka Kolehmainen, Anu Siponen, Teemu Smura, Hannimari Kallio-Kokko, Olli Vapalahti, Anne Jääskeläinen, Sisko Tauriainen
BACKGROUND: Human parechoviruses (HPeVs) (family Picornaviridae), are common pathogens in young children. Despite their high prevalence, research on their genetic identity, diversity and evolution have remained scarce. OBJECTIVES: Complete coding regions of three previously reported HPeV-4 isolates from Finnish children with sepsis-like disease were sequenced in order to elucidate the phylogenetic relationships and potential recombination events during the evolution of these isolates...
January 3, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/27977558/intensive-care-admissions-for-children-with-enterovirus-and-human-parechovirus-infections-in-the-united-kingdom-and-the-republic-of-ireland-2010-14
#2
Serena Braccio, Melpo Kapetanstrataki, Mike Sharland, Shamez Ladhani
Enteroviruses and human parechoviruses (EV/HPeV) usually cause mild, self-limiting illnesses in children but can occasionally cause severe disease. During 2010-14, 104 children in the UK and the Republic of Ireland were admitted to a pediatric intensive care unit with severe EV/HPeV infection; 40% had neurologic symptoms, 20% respiratory failure, 16% cardiac complications and 11% septic shock. Annual number of cases and incidence increased in the five-year period, from 0.6/1,000 PICU admissions (12 cases) in 2010 to 1...
December 12, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27940759/human-parechovirus-as-a-cause-of-isolated-pediatric-acute-liver-failure
#3
Amee M Bigelow, John P Scott, Johnny C Hong, David C Cronin, Bernadette E Vitola, Roger A Fons, Tara L Petersen
Among infants, almost half of acute liver failure cases are classified as indeterminate, whereas only a small number of cases show a documented viral infection. We present the first reported case of isolated acute hepatic failure in an infant in the setting of a human parechovirus (HPeV) infection. HPeV also may have been contributory to the posttransplant complication of 2 intussusceptions. This is a 10-month-old girl who presented with only symptoms of fussiness and was noted to have progressive decline in synthetic liver function as well as worsening coagulopathy requiring a liver transplant...
November 2016: Pediatrics
https://www.readbyqxmd.com/read/27925289/seroepidemiology-of-human-parechovirus-types-1-3-and-6-in-yamagata-japan-in-2014
#4
Shizuka Tanaka, Yoko Aoki, Yohei Matoba, Kazue Yahagi, Tsutomu Itagaki, Yoko Matsuzaki, Katsumi Mizuta
To clarify the seroepidemiology of human parechovirus type 1 (HPeV1), 3 and 6, neutralizing antibodies (NT Abs) were measured in 214 serum specimens collected in 2014 in Yamagata, Japan. The seroprevalence against HPeV1 was 100% for all age groups, while that against HPeV3 and HPeV6 among all residents was 79.4% and 66.8%, respectively. The genometric mean titers of NT Abs against HPeV1, 3 and 6 among all residents were 755.2, 255.0 and 55.8, respectively. Our study indicated that HPeV1 is the most prevalent HPeV circulating in Yamagata, followed by HPeV3 and HPeV6...
December 7, 2016: Microbiology and Immunology
https://www.readbyqxmd.com/read/27914285/human-parechovirus-and-enterovirus-initiate-distinct-cns-innate-immune-responses-pathogenic-and-diagnostic-implications
#5
Danielle Fortuna, Ana María Cárdenas, Erin H Graf, Larry A Harshyne, D Craig Hooper, Michael Prosniak, John Shields, Mark T Curtis
BACKGROUND: Human parechovirus (HPeV) and enterovirus (EV) cause a range of human diseases including serious CNS infections. Little is known regarding the immune response to HPeV meningitis compared to EV meningitis or how the immune response to HPeV reflects its pathogenesis. OBJECTIVE: To characterize the innate immune response to HPeV CNS infection in order to increase our understanding of HPeV pathogenesis and possibly help identify HPeV in the clinical setting...
January 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/27905621/-parechovirus-as-etiologic-agent-of-meningitis-and-or-sepsis-like-illness-in-infants
#6
Valentina Gutiérrez, Constanza Martínez-Valdebenito, Luisa Montecinos, Romina Alarcón, Constanza Gárate, Marcela Ferrés
INTRODUCTION: Human parechovirus (HPeV) belongs to the Picornaviridae family and has been described in viral meningoencephalitis and sepsis like illness in infants. Until now, 16 genotypes have been recognized, the most common are HPEV 1, 2 and 3; type 3 is most severe. AIMS: To estimate the frequency of HPEV etiology in viral meningoencephalitis and sepsis in infants and characterize clinical and molecular aspects of infection. METHODS: Between October 2013 and March 2015 we collected CSF samples, plasma, nasopharyngeal swabs and/or stools of patients younger than two years with suspected sepsis and/or viral meningitis...
August 2016: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/27851439/1804-parechovirus-an-elusive-cause-of-neonatal-encephalopathy
#7
Jaime Jump, Ajit Mammen
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27826360/genome-analysis-revealed-novel-genotypes-and-recombination-of-the-human-parechoviruses-prevalent-in-children-in-eastern-china
#8
Xiangyang Zhao, Yongqiang Shi, Yu Xia
BACKGROUND: Human parechovirus (HPeV) is a genus of virus in the family Picornaviridae, having two species A and B. HPeVs are common infectious agents, usually causing mild diarrhea and respiratory disease in young children. RESULTS: Here, we collected and sequenced the near complete genome sequences of 17 novel HPeVs from children with diarrhea in eastern China, which showed significant nucleotide sequence divergence. Phylogenetic analysis based on the complete genomes of these HPeV strains revealed that they belonged to seven different genotypes (including three putative novel genotypes), suggesting that HPeVs showed genotype diversity in this area...
2016: Gut Pathogens
https://www.readbyqxmd.com/read/27826297/lipopolysaccharide-attenuates-induction-of-proallergic-cytokines-thymic-stromal-lymphopoietin-and-interleukin-33-in-respiratory-epithelial-cells-stimulated-with-polyi-c-and-human-parechovirus
#9
Tsang-Hsiung Lin, Chih-Chi Cheng, Hsing-Hao Su, Nan-Chieh Huang, Jih-Jung Chen, Hong-Yo Kang, Tsung-Hsien Chang
Epidemiological studies based on the "hygiene hypothesis" declare that the level of childhood exposure to environmental microbial products is inversely related to the incidence of allergic diseases in later life. Multiple types of immune cell-mediated immune regulation networks support the hygiene hypothesis. Epithelial cells are the first line of response to microbial products in the environment and bridge the innate and adaptive immune systems; however, their role in the hygiene hypothesis is unknown. To demonstrate the hygiene hypothesis in airway epithelial cells, we examined the effect of lipopolysaccharide (LPS; toll-like receptor 4 ligand) on the expression of the proallergic cytokines thymic stromal lymphopoietin (TSLP) and interleukin 33 (IL33) in H292 cells (pulmonary mucoepidermoid carcinoma cells)...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27816019/molecular-detection-of-human-parechovirus-in-under-five-year-old-children-with-gastroenteritis
#10
Massimiliano Bergallo, Ilaria Galliano, Paola Montanari, Martina Rosa Brusin, Clara Gabiano
BACKGROUND: Currently, RT-PCR is used widely and considered to be a convenient, useful, and powerful method for molecular diagnosis, to detect pathogens from clinical specimens. OBJECTIVES: In this work we describe the development of an in-house Real-time Taqman PCR assay for quantification of HPeV in stool specimens. STUDY DESIGNS: A total of 137 fecal specimens previously screened for rotavirus and adenovirus were tested for HPeV virus. RESULTS: A total of 11 out of 137 (8%) episodes of acute gastroenteritis were associated with HPeV genomic detection with median viral load 14678±28927 genomes/mg fecal specimens...
October 26, 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/27749661/a-4-year-study-on-epidemiologic-and-molecular-characteristics-of-human-parechoviruses-and-enteroviruses-circulating-in-children-younger-than-5-years-in-northern-italy
#11
Laura Bubba, Marianna Martinelli, Laura Pellegrinelli, Valeria Primache, Elisabetta Tanzi, Elena Pariani, Sandro Binda
BACKGROUND: Human parechovirus (HPeV) and enterovirus (EV) infections are widespread and can lead to a broad range of symptoms, from the common cold to severe disease (SD). Because of the lack of Italian data, this 4-year retrospective cross-sectional study aimed to investigate the frequency, seasonality and molecular characteristics of EV and HPeV circulating in children younger than 5 years. METHODS: A total of 812 samples were collected from children ≤5 years (56...
January 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27736008/detection-of-gastroenteritis-viruses-among-pediatric-patients-in-hiroshima-prefecture-japan-between-2006-and-2013-using-multiplex-reverse-transcription-pcr-based-assays-involving-fluorescent-dye-labeled-primers
#12
Naoki Shigemoto, Yuri Hisatsune, Yasushi Toukubo, Yukie Tanizawa, Yukie Shimazu, Shinichi Takao, Tomoyuki Tanaka, Mamoru Noda, Shinji Fukuda
Multiplex reverse transcription (RT)-polymerase chain reaction (PCR)-based assays involving fluorescent dye-labeled primers were modified to detect 10 types of gastroenteritis viruses by adding two further assays to a previously developed assay. Then, these assays were applied to clinical samples, which were collected between January 2006 and December 2013. All 10 types of viruses were effectively detected in the multiplex RT-PCR-based assays. In addition, various viral parameters, such as the detection rates and age distributions of each viral type, were examined...
October 13, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27735999/multiplex-rt-pcr-for-rapid-detection-of-viruses-commonly-causing-diarrhea-in-pediatric-patients
#13
Aksara Thongprachum, Pattara Khamrin, Ngan Thi Kim Pham, Sayaka Takanashi, Shoko Okitsu, Hiroyuki Shimizu, Niwat Maneekarn, Satoshi Hayakawa, Hiroshi Ushijima
Multiplex RT-PCR method using five sets of panel primers was developed for the detection of diarrheal viruses, including rotavirus A, B, and C, adenovirus, astrovirus, norovirus GI and GII, sapovirus, Aichi virus, parechovirus, enterovirus, cosavirus, bocavirus, and Saffold virus. The sensitivity of the method was evaluated and tested with 751 fecal specimens collected from Japanese children with acute diarrhea. Several kinds of viruses were detected in 528 out of 751 (70.3%) fecal specimens. Mixed-infection with different viruses in clinical specimens could also be effectively detected...
October 13, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27690140/performance-of-a-real-time-pcr-based-approach-and-droplet-digital-pcr-in-detecting-human-parechovirus-type-3-rna
#14
Yuta Aizawa, Akihide Koyama, Tomohiko Ishihara, Osamu Onodera, Akihiko Saitoh
BACKGROUND: Human parechovirus type 3 (HPeV3) is an emerging virus that causes sepsis and meningoencephalitis in neonates and young infants. Correct diagnosis of HPeV3 infection is critical in determining appropriate management and predicting patients' clinical course. Real-time reverse transcription PCR (RT-PCR) analysis of serum and/or cerebrospinal fluid (CSF) has been used to diagnose HPeV3 infection; however, the assay detection limits have not been fully evaluated. OBJECTIVES: We tested the hypothesis that droplet digital RT-PCR (RT-ddPCR)-a novel technique that precisely quantitates low-copy target genes by diluting and partitioning samples into compartments-increases the detection rate of HPeV3 RNA as compared with real-time RT-PCR...
November 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/27686253/first-detection-of-human-parechovirus-infection-with-diarrhoea-india
#15
Krishna Chaaithanya Itta, Kirti Vittal Ghargi, Shanta Kalal, Tanmayi Patil, Subarna Roy
No abstract text is available yet for this article.
February 2017: Infectious Diseases
https://www.readbyqxmd.com/read/27636724/extreme-hyperferritinemia-in-dizygotic-twins-with-human-parechovirus-3-infection
#16
Dídac Casas-Alba, Antonio Martínez-Monseny, Laura Monfort, Carmen Muñoz-Almagro, María Cabrerizo, Àngela Deyà, Cristian Launes
Human parechovirus-3 has been associated with severe clinical manifestations in infants, such as sepsis-like illness and meningoencephalitis. Nevertheless, the vast majority of patients have a favorable outcome. We report the occurrence of this infection in dizygotic infants with extreme hyperferritinemia and a transient impairment of natural-killer cell cytotoxicity.
September 15, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27589339/cluster-of-human-parechovirus-infections-as-the-predominant-cause-of-sepsis-in-neonates-and-infants-leicester-united-kingdom-8-may-to-2-august-2016
#17
Julian W Tang, Christopher W Holmes, Fadwa A Elsanousi, Ayushi Patel, Fazila Adam, Rachel Speight, Savitha Shenoy, Daniel Bronnert, Gary Stiefel, Premkumar Sundaram, Suchandra Pande, Arani Sridhar, Venkatesh Kairamkonda, Srini Bandi
We report an unusually high number of cases (n = 26) of parechovirus infections in the cerebrospinal fluid (CSF) of neonates and infants admitted with sepsis in the United Kingdom during 8 May to 2 August 2016. Although such infections in neonates and infants are well-documented, parechovirus has not been routinely included in many in-house and commercial PCR assays for CSF testing. Clinicians should consider routine parechovirus testing in young children presenting with sepsis.
August 25, 2016: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/27588032/distinctive-clinical-features-of-hpev-3-infection-in-2-neonates-with-a-sepsis-like-illness
#18
Jung Sook Yeom, Ji Sook Park, Ji-Hyun Seo, Eun Sil Park, Jae-Young Lim, Chan-Hoo Park, Hyang-Ok Woo, Hee-Shang Youn, Ok Jeong Lee, Tae-Hee Han, Ju-Young Chung
We report a human parechovirus-3 (HPeV-3) infection in 2 neonates who had prolonged fever (>5 days) with palmar-plantar erythema. This distinctive rash was observed 4-5 days after fever onset, just before defervescence. Elevated aspartate aminotransferase, lactate dehydrogenase, and ferritin levels were characteristic laboratory findings in the 2 cases, suggesting tissue damage caused by hypercytokinemia. Case 1 was treated with intravenous immunoglobulin, considering the possibility of severe systemic inflammatory responses...
July 2016: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/27571735/seropositivity-and-epidemiology-of-human-parechovirus-types-1-3-and-6-in-japan
#19
K Watanabe, C Hirokawa, T Tazawa
Human parechoviruses (HPeVs) mainly infect young children, causing mild gastrointestinal and respiratory diseases; however, HPeV type 3 (HPeV3) causes severe systemic diseases in young infants. To clarify the characteristics of HPeV infections from the aspects of seropositivity and epidemiology, we measured neutralizing antibody titres against HPeVs in individuals of in different age groups and isolated HPeVs from various clinical specimens in Niigata, Japan. The seropositivity to HPeV1, 3, and 6 was higher in older age group...
August 30, 2016: Epidemiology and Infection
https://www.readbyqxmd.com/read/27532333/nosocomial-outbreak-of-parechovirus-3-infection-among-newborns-austria-2014
#20
Volker Strenger, Sabine Diedrich, Sindy Boettcher, Susanne Richter, Peter Maritschnegg, Dietmar Gangl, Simone Fuchs, Gernot Grangl, Bernhard Resch, Berndt Urlesberger
In 2014, sepsis-like illness affected 9 full-term newborns in 1 hospital in Austria. Although results of initial microbiological testing were negative, electron microscopy identified picornavirus. Archived serum samples and feces obtained after discharge were positive by PCR for human parechovirus 3. This infection should be included in differential diagnoses of sepsis-like illness in newborns.
September 2016: Emerging Infectious Diseases
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