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Parechovirus

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https://www.readbyqxmd.com/read/29223126/hpev-3-predominated-among-parechovirus-a-positive-infants-during-an-outbreak-in-2013-2014-in-queensland-australia
#1
Donna McNeale, Claire Y T Wang, Katherine E Arden, Ian M Mackay
BACKGROUND: Parechoviruses (HPeV) are endemic seasonal pathogens detected from the respiratory tract, gut, blood and central nervous system (CNS) of children and adults, sometimes in conjunction with a range of acute illnesses. HPeV CNS infection may lead to neurodevelopmental sequelae, especially following infection by HPeV-3, hence screening and genotyping are important to inform epidemiology, aetiology and prognosis. OBJECTIVES: To identify and characterise HPeVs circulating during an outbreak between November 2013 and April 2014 in Queensland, Australia...
December 6, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29207707/diagnostic-approach-to-viral-acute-encephalitis-syndrome-aes-in-paediatric-age-group-a-study-from-new-delhi
#2
Shipra Goel, Anita Chakravarti, Mukta Mantan, Surinder Kumar, Md Anzar Ashraf
Introduction: Acute Encephalitis Syndrome has heralded the emergence of multiple virulent pathogens, which may result in severe morbidity and mortality. In India, encephalitis is not notified and there has been a dearth of analysis for trends in encephalitis death rates and causation. A downward trend has been observed in encephalitis deaths, due to 'known' causes, which can be largely explained by improvement in diagnostic, treatment, and prevention methods. There is still a very high proportion of encephalitis deaths in developing countries, where the aetiological diagnosis of the pathogen is not established and thus, lies the importance of monitoring encephalitis morbidity and mortality with a view to improve pathogen diagnosis and identify emerging infectious diseases...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29205679/prevalence-and-characteristics-of-human-parechovirus-and-enterovirus-infections-in-febrile-infants
#3
Kentaro Sano, Hiromichi Hamada, Shoko Hirose, Kenta Sugiura, Satoko Harada, Mai Koizumi, Mayumi Hara, Haruna Nishijima, Masakatsu Taira, Atsushi Ogura, Tomoko Ogawa, Jun-Ichi Takanashi
BACKGROUND: Human parechovirus (HPeV) and human non-polio enterovirus (EV) are important causes of fever without sources (FWS) in young infants. Their prevalence and clinical characteristics are largely unknown in Asian countries. This study was conducted to elucidate the epidemiology and clinical characteristics of HPeV and EV infections in febrile young infants in Japan. METHODS: During February 2010 - August 2015, we obtained 53 stool, 44 throat swab, and 20 cerebrospinal fluid (CSF) samples from 56 infants (<3 months) with FWS at a single hospital...
December 5, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29205494/acral-accentuated-exanthem-in-an-infant-with-parechovirus-meningitis
#4
Dawn Lee, Sin Wee Loh, Juliet Tan, Jinho Chong
We report a case of an infant who had presented with fever and an acral-accentuated rash, for which his cerebrospinal fluid returned positive for parechovirus. He was treated symptomatically and discharged well, with no long-term complications.
December 4, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29173223/epidemiology-and-genetic-diversity-of-human-parechoviruses-circulating-among-children-hospitalised-with-acute-gastroenteritis-in-pune-western-india-a-5-years-study
#5
P R Patil, N N Ganorkar, V Gopalkrishna
Human parechoviruses (HPeVs) are known to cause various clinical manifestations including acute gastroenteritis. Although HPeV infections and their genotypes have been detected in human patients worldwide, no such reports are available from India to ascertain the association of HPeVs in acute gastroenteritis. The present study was conducted to determine the clinical features and genetic diversity of HPeVs detected in children hospitalised for acute gastroenteritis. Stool specimens (n = 979) collected from children aged ⩽5 years hospitalised for acute gastroenteritis in Pune, western India during January 2006-December 2010 were included...
November 27, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/29155163/antifungal-azoles-itraconazole-and-posaconazole-exhibit-potent-in-vitro-antiviral-activity-against-clinical-isolates-of-parechovirus-a3-picornaviridae
#6
Eric Rhoden, W Allan Nix, William C Weldon, Rangaraj Selvarangan
Parechovirus A3 (Par-A3, formerly human parechovirus 3) is an emerging viral infection of the central nervous system in children. We used an automated, homogeneous, cell based assay to identify itraconazole and posaconazole as inhibitors of Par-A3, with antiviral activity below concentrations clinically attainable in pediatric patients. Currently, there is no approved antiviral treatment for Par-A3 infection, despite numerous reports of serious Par-A3 disease in neonates and infants.
November 15, 2017: Antiviral Research
https://www.readbyqxmd.com/read/29149199/epidemiology-and-clinical-profile-of-pathogens-responsible-for-the-hospitalization-of-children-in-sousse-area-tunisia
#7
Ines Brini, Aida Guerrero, Naila Hannachi, Jihene Bouguila, Dorothea Orth-Höller, Amira Bouhlel, Lamia Boughamoura, Benjamin Hetzer, Wegene Borena, Britta Schiela, Dorothee Von Laer, Jalel Boukadida, Heribert Stoiber
This study aimed to identify a broad spectrum of respiratory pathogens from hospitalized and not-preselected children with acute respiratory tract infections in the Farhat Hached University-hospital of Sousse, Tunisia. Between September 2013 and December 2014, samples from 372 children aged between 1 month and 5 years were collected, and tested using multiplex real-time RT-PCR by a commercial assay for 21 respiratory pathogens. In addition, samples were screened for the presence of Streptococcus pneumoniae 16S rDNA using real-time PCR...
2017: PloS One
https://www.readbyqxmd.com/read/29142080/human-parechovirus-an-increasingly-recognized-cause-of-sepsis-like-illness-in-young-infants
#8
REVIEW
Laudi Olijve, Lance Jennings, Tony Walls
Human parechovirus (HPeV) is increasingly being recognized as a potentially severe viral infection in neonates and young infants. HPeV belongs to the family Picornaviridae and is currently divided into 19 genotypes. HPeV-1 is the most prevalent genotype and most commonly causes gastrointestinal and respiratory disease. HPeV-3 is clinically the most important genotype due to its association with severe disease in younger infants, which may partly be explained by its distinct virological properties. In young infants, the typical clinical presentation includes fever, severe irritability, and rash, often leading to descriptions of "hot, red, angry babies...
January 2018: Clinical Microbiology Reviews
https://www.readbyqxmd.com/read/29115952/no-evidence-of-enteric-viral-involvement-in-the-new-neonatal-porcine-diarrhoea-syndrome-in-danish-pigs
#9
N B Goecke, C K Hjulsager, H Kongsted, M Boye, S Rasmussen, F Granberg, T K Fischer, S E Midgley, L D Rasmussen, Ø Angen, J P Nielsen, S E Jorsal, L E Larsen
BACKGROUND: The aim of this study was to investigate whether the syndrome New Neonatal Porcine Diarrhoea Syndrome (NNPDS) is associated with a viral aetiology. Four well-managed herds experiencing neonatal diarrhoea and suspected to be affected by NNPDS were included in a case-control set up. A total of 989 piglets were clinically examined on a daily basis. Samples from diarrhoeic and non-diarrhoeic piglets at the age of three to seven days were selected for extensive virological examination using specific real time polymerase chain reactions (qPCRs) and general virus detection methods...
November 7, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29106347/epidemiology-and-molecular-characterization-of-influenza-viruses-human-parechoviruses-and-enteroviruses-in-children-up-to-5-years-with-influenza-like-illness-in-northern-italy-during-seven-consecutive-winter-seasons-2010-2017
#10
Laura Pellegrinelli, Laura Bubba, Cristina Galli, Giovanni Anselmi, Valeria Primache, Sandro Binda, Elena Pariani
Besides the influenza virus (IV), several other viruses are responsible for influenza-like illness (ILI). Although human parechoviruses (HPeVs) and enteroviruses (EVs) may impact on ILI, limited data on their epidemiological characteristics are available. During seven consecutive winter seasons (from 2010-2011 to 2016-2017), within the framework of an influenza surveillance system (InfluNet), 593 respiratory swabs were collected from children ≤5 years of age with ILIs. Molecular detection showed that 58...
November 2017: Journal of General Virology
https://www.readbyqxmd.com/read/29055866/high-diversity-of-human-parechovirus-including-novel-types-in-stool-samples-from-ghanaian-children
#11
Silke Graul, Sindy Böttcher, Daniel Eibach, Ralf Krumkamp, Julia Käsmaier, Yaw Adu-Sarkodie, Jürgen May, Egbert Tannich, Marcus Panning
BACKGROUND: Little is known on human parechovirus (HPeV) infections in Africa. OBJECTIVES: We aimed to determine the prevalence, genetic diversity, and association with diarrhea of HPeV in Ghanaian children. STUDY DESIGN: A total of 682 stool samples from a pediatric case-control study on causes of diarrhea collected in 2007-2008 were used. Laboratory analysis included HPeV real-time RT-PCR and sequencing partial viral protein (VP) 1 gene region of HPeV...
October 18, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28960646/high-prevalence-of-developmental-concern-amongst-infants-at-12-months-following-hospitalised-parechovirus-infection
#12
Philip N Britton, Gulam Khandaker, Ameneh Khatami, Suzy Teutsch, Stephanie Francis, Brendan J McMullan, Cheryl A Jones
AIM: The human parechovirus (HPeV) is an increasingly recognised cause of sepsis and central nervous system infection in young infants for which there are limited long-term outcome data. We aimed to assess neurodevelopmental outcome and quality of life in infants following hospitalised HPeV infection. METHODS: This cohort study was a 12-month follow-up of infants who were hospitalised with confirmed HPeV infection at the Sydney Children's Hospitals Network during an outbreak in Sydney in 2013...
September 28, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28935894/strain-dependent-neutralization-reveals-antigenic-variation-of-human-parechovirus-3
#13
Eveliina Karelehto, Sabine van der Sanden, James A Geraets, Aušra Domanska, Lonneke van der Linden, Dionne Hoogendoorn, Gerrit Koen, Hetty van Eijk, Shabih Shakeel, Tim Beaumont, Menno de Jong, Dasja Pajkrt, Sarah J Butcher, Katja C Wolthers
Human parechovirus 3 (HPeV3), a member of the Picornavirus family, is frequently detected worldwide. However, the observed seropositivity rates for HPeV3 neutralizing antibodies (nAbs) vary from high in Japan to low in the Netherlands and Finland. To study if this can be explained by technical differences or antigenic diversity among HPeV3 strains included in the serological studies, we determined the neutralizing activity of Japanese and Dutch intravenous immunoglobulin batches (IVIG), a rabbit HPeV3 hyperimmune polyclonal serum, and a human HPeV3-specific monoclonal antibody (mAb) AT12-015, against the HPeV3 A308/99 prototype strain and clinical isolates from Japan, the Netherlands and Australia, collected between 1989 and 2015...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28893485/-clinical-characteristics-and-course-of-hand-foot-and-mouth-disease
#14
A Mirand, H Peigue-Lafeuille
Hand, foot and mouth disease (HFMD) and herpangina (HA) are common childhood diseases mostly associated with human enteroviruses (EV). Although usually benign illnesses, neurological complications may be observed during large epidemics when enterovirus A71 (EV-A71) is involved, as observed in the Asia Pacific Region and in China since the late 1990s. The occurrence of these complications warrants reinforcing the surveillance of the emergence of EV-A71 infections in France and Europe. Monitoring EV infections associated with HFMD can be considered as an effective tool to detect an upsurge of EV-A71 infections in a timely manner...
September 8, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28891004/cerebral-imaging-and-neurodevelopmental-outcome-after-entero-and-human-parechovirus-sepsis-in-young-infants
#15
Eveline P de Jong, Herma C Holscher, Sylke J Steggerda, Jeanine M M Van Klink, Erika P M van Elzakker, Enrico Lopriore, Frans J Walther, Frank Brus
Enterovirus (EV) and human parechovirus (HPeV) are major causes of sepsis-like illness in infants under 90 days of age and have been identified as neurotropic. Studies about acute and long-term neurodevelopment in infants with sepsis-like illness without the need for intensive care are few. This study investigates cerebral imaging and neurodevelopmental outcome following EV and HPeV infection in these infants. We studied infants under 90 days of age who were admitted to a medium care unit with proven EV- or HPeV-induced sepsis-like illness...
December 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28886185/clinical-features-and-seasonality-of-parechovirus-infection-in-an-asian-subtropical-city-hong-kong
#16
Grace P K Chiang, Zigui Chen, Martin C W Chan, Simon H M Lee, Angela K Kwok, Apple C M Yeung, E Anthony S Nelson, Kam Lun Hon, Ting Fan Leung, Paul K S Chan
BACKGROUND: The epidemiology of human parechovirus (HPeV) in Asia remains obscure. We elucidated the prevalence, seasonality, type distribution and clinical presentation of HPeV among children in Hong Kong. METHODS: A 24-month prospective study to detect HPeV in children ≤36 months hospitalized for acute viral illnesses. RESULTS: 2.3% of the 3911 children examined had HPeV infection, with most (87.5%) concentrated in September-January (autumn-winter)...
2017: PloS One
https://www.readbyqxmd.com/read/28882730/complete-genome-sequence-of-the-first-human-parechovirus-type-3-isolated-in-taiwan
#17
Jenn-Tzong Chang, Chih-Shiang Yang, Bao-Chen Chen, Yao-Shen Chen, Tsung-Hsien Chang
The first human parechovirus 3 (HPeV3 VGHKS-2007) in Taiwan was identified from a clinical specimen from a male infant. The entire genome of the HPeV3 isolate was sequenced and compared to known HPeV3 sequences. Genome alignment data showed that HPeV3 VGHKS-2007 shares the highest nucleotide identity, 99%, with the Japanese strain of HPeV3 1361K-162589-Yamagata-2008. All HPeV3 isolates possess at least 97% amino acid identity. The analysis of the genome sequence of HPeV3 VGHKS-2007 will facilitate future investigations of the epidemiology and pathogenicity of HPeV3 infection...
September 4, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28855493/clinical-characteristics-of-17-adult-patients-with-epidemic-myalgia-associated-with-human-parechovirus-type-3-infection
#18
Tatsushi Yamakawa, Katsumi Mizuta, Katsurou Kurokawa, Hikaru Nagasawa, Takahiro Yamada, Emiko Suzuki, Manabu Wada
We investigated 17 adult cases (14 males and 3 females) of myalgia induced by human parechovirus type 3 (HPeV3) infection, treated during the summers of 2008, 2011, 2014, and 2016. The patients were aged between 21 and 50 years. The limbs and trunk of all patients were affected, and severe myalgia, muscle weakness, and decreased grip strength were observed. In addition to myalgia and muscle weakness, symptoms included fever in 14 (82%), upper respiratory inflammation in 8 (47%), gastroenteritis in 4 (24%), and scrotal pain in 4 (29% of males) patients...
September 30, 2017: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/28843546/ljungan-sebokele-like-picornavirus-in-birds-of-prey-common-kestrel-falco-tinnunculus-and-red-footed-falcon-f-vespertinus
#19
Péter Pankovics, Ákos Boros, Róbert Mátics, Beatrix Kapusinszky, Eric Delwart, Gábor Reuter
Ljungan and Sebokele viruses are thought to be rodent-borne (picorna)viruses in the genus Parechovirus. Using random amplification and next generation sequencing method a novel Ljungan/Sebokele-like picornavirus was identified in birds of prey. Viral RNA was detected in total of 1 (9%) of the 11 and 2 (28.6%) of the 7 faecal samples from common kestrels and red-footed falcons in Hungary, respectively. High faecal viral RNA load (4.77×10(6) genomic copies/ml) measured by qPCR. The complete genome of picornavirus strain falcon/HA18_080/2014/HUN (KY645497) is 7964-nucleotide (nt) long including a 867-nt 5'end and a 101-nt 3'end (excluding the poly(A)-tail)...
August 24, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28820382/myocarditis-caused-by-human-parechovirus-in-adult
#20
Khai Lin Kong, Jillian S Y Lau, Su Mei Goh, Heather L Wilson, Mike Catton, Tony M Korman
The infectious etiology of myocarditis often remains unidentified. We report a case of myocarditis associated with human parechovirus (HPeV) infection in an adult. HPeV is an emerging pathogen that can cause serious illness, including myocarditis, in adults. Testing for HPeV should be considered in differential diagnosis of myocarditis.
September 2017: Emerging Infectious Diseases
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