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https://www.readbyqxmd.com/read/28893485/-clinical-characteristics-and-course-of-hand-foot-and-mouth-disease
#1
A Mirand, H Peigue-Lafeuille
Hand, foot and mouth disease (HFMD) and herpangina (HA) are common childhood diseases mostly associated with human enteroviruses (EV). Although usually benign illnesses, neurological complications may be observed during large epidemics when enterovirus A71 (EV-A71) is involved, as observed in the Asia Pacific Region and in China since the late 1990s. The occurrence of these complications warrants reinforcing the surveillance of the emergence of EV-A71 infections in France and Europe. Monitoring EV infections associated with HFMD can be considered as an effective tool to detect an upsurge of EV-A71 infections in a timely manner...
September 8, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28891004/cerebral-imaging-and-neurodevelopmental-outcome-after-entero-and-human-parechovirus-sepsis-in-young-infants
#2
Eveline P de Jong, Herma C Holscher, Sylke J Steggerda, Jeanine M M Van Klink, Erika P M van Elzakker, Enrico Lopriore, Frans J Walther, Frank Brus
Enterovirus (EV) and human parechovirus (HPeV) are major causes of sepsis-like illness in infants under 90 days of age and have been identified as neurotropic. Studies about acute and long-term neurodevelopment in infants with sepsis-like illness without the need for intensive care are few. This study investigates cerebral imaging and neurodevelopmental outcome following EV and HPeV infection in these infants. We studied infants under 90 days of age who were admitted to a medium care unit with proven EV- or HPeV-induced sepsis-like illness...
September 10, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28886185/clinical-features-and-seasonality-of-parechovirus-infection-in-an-asian-subtropical-city-hong-kong
#3
Grace P K Chiang, Zigui Chen, Martin C W Chan, Simon H M Lee, Angela K Kwok, Apple C M Yeung, E Anthony S Nelson, Kam Lun Hon, Ting Fan Leung, Paul K S Chan
BACKGROUND: The epidemiology of human parechovirus (HPeV) in Asia remains obscure. We elucidated the prevalence, seasonality, type distribution and clinical presentation of HPeV among children in Hong Kong. METHODS: A 24-month prospective study to detect HPeV in children ≤36 months hospitalized for acute viral illnesses. RESULTS: 2.3% of the 3911 children examined had HPeV infection, with most (87.5%) concentrated in September-January (autumn-winter)...
2017: PloS One
https://www.readbyqxmd.com/read/28882730/complete-genome-sequence-of-the-first-human-parechovirus-type-3-isolated-in-taiwan
#4
Jenn-Tzong Chang, Chih-Shiang Yang, Bao-Chen Chen, Yao-Shen Chen, Tsung-Hsien Chang
The first human parechovirus 3 (HPeV3 VGHKS-2007) in Taiwan was identified from a clinical specimen from a male infant. The entire genome of the HPeV3 isolate was sequenced and compared to known HPeV3 sequences. Genome alignment data showed that HPeV3 VGHKS-2007 shares the highest nucleotide identity, 99%, with the Japanese strain of HPeV3 1361K-162589-Yamagata-2008. All HPeV3 isolates possess at least 97% amino acid identity. The analysis of the genome sequence of HPeV3 VGHKS-2007 will facilitate future investigations of the epidemiology and pathogenicity of HPeV3 infection...
September 4, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28855493/clinical-characteristics-of-17-adult-patients-with-epidemic-myalgia-associated-with-human-parechovirus-type-3-infection
#5
Tatsushi Yamakawa, Katsumi Mizuta, Katsurou Kurokawa, Hikaru Nagasawa, Takahiro Yamada, Emiko Suzuki, Manabu Wada
We investigated 17 adult cases (14 males and 3 females) of myalgia induced by human parechovirus type 3 (HPeV3) infection, treated during the summers of 2008, 2011, 2014, and 2016. The patients were aged between 21 and 50 years. The limbs and trunk of all patients were affected, and severe myalgia, muscle weakness, and decreased grip strength were observed. In addition to myalgia and muscle weakness, symptoms included fever in 14 (82%), upper respiratory inflammation in 8 (47%), gastroenteritis in 4 (24%), and scrotal pain in 4 (29% of males) patients...
August 31, 2017: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/28843546/ljungan-sebokele-like-picornavirus-in-birds-of-prey-common-kestrel-falco-tinnunculus-and-red-footed-falcon-f-vespertinus
#6
Péter Pankovics, Ákos Boros, Róbert Mátics, Beatrix Kapusinszky, Eric Delwart, Gábor Reuter
Ljungan and Sebokele viruses are thought to be rodent-borne (picorna)viruses in the genus Parechovirus. Using random amplification and next generation sequencing method a novel Ljungan/Sebokele-like picornavirus was identified in birds of prey. Viral RNA was detected in total of 1 (9%) of the 11 and 2 (28.6%) of the 7 faecal samples from common kestrels and red-footed falcons in Hungary, respectively. High faecal viral RNA load (4.77×10(6) genomic copies/ml) measured by qPCR. The complete genome of picornavirus strain falcon/HA18_080/2014/HUN (KY645497) is 7964-nucleotide (nt) long including a 867-nt 5'end and a 101-nt 3'end (excluding the poly(A)-tail)...
August 24, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28820382/myocarditis-caused-by-human-parechovirus-in-adult
#7
Khai Lin Kong, Jillian S Y Lau, Su Mei Goh, Heather L Wilson, Mike Catton, Tony M Korman
The infectious etiology of myocarditis often remains unidentified. We report a case of myocarditis associated with human parechovirus (HPeV) infection in an adult. HPeV is an emerging pathogen that can cause serious illness, including myocarditis, in adults. Testing for HPeV should be considered in differential diagnosis of myocarditis.
September 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28763426/epidemiology-of-sepsis-like-illness-in-young-infants-major-role-of-enterovirus-and-human-parechovirus
#8
Eveline P de Jong, Monique G A van den Beuken, Erika P M van Elzakker, K C Wolthers, Arwen J Sprij, E Lopriore, Frans J Walther, Frank Brus
BACKGROUND: Sepsis-like illness is a main cause for hospital admission in young infants. Our aim was to investigate incidence, epidemiology and clinical characteristics of enterovirus (EV) and human parechovirus (HPeV) infections in young infants with sepsis-like illness. METHODS: This is a prospective observational cohort study in which infants younger than 90 days of age, presenting with sepsis-like symptoms in a secondary care children's hospital, underwent a full sepsis work-up...
July 31, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28737006/unrecognized-viral-infections-and-chromosome-abnormalities-as-a-cause-of-fetal-death-examination-with-fluorescence-in%C3%A2-situ-hybridization-immunohistochemistry-and-polymerase-chain-reaction
#9
Bente Ediassen Opsjøn, Svein Arne Nordbø, Christina Vogt
Fifteen to 50% of fetal deaths remain unexplained after post-mortem examination depending on inclusion criteria and classification systems. Our aim was to examine a selection of unexplained fetal deaths in order to investigate whether any common chromosome aberrations or viral infections were present. Reports from 351 fetal autopsies performed at the Department of Pathology and Medical Genetics at St. Olavs University Hospital from 2001 through 2010 were reviewed. Of these, 105 fetal deaths were classified as unexplained...
September 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28710463/erratum-genomic-rna-folding-mediates-assembly-of-human-parechovirus
#10
Shabih Shakeel, Eric C Dykeman, Simon J White, Ari Ora, Joseph J B Cockburn, Sarah J Butcher, Peter G Stockley, Reidun Twarock
A correction has been published and is appended to both the HTML and PDF versions of this paper. The error has not been fixed in the paper.
July 14, 2017: Nature Communications
https://www.readbyqxmd.com/read/28696303/intestinal-virome-changes-precede-autoimmunity-in-type-i-diabetes-susceptible-children
#11
Guoyan Zhao, Tommi Vatanen, Lindsay Droit, Arnold Park, Aleksandar D Kostic, Tiffany W Poon, Hera Vlamakis, Heli Siljander, Taina Härkönen, Anu-Maaria Hämäläinen, Aleksandr Peet, Vallo Tillmann, Jorma Ilonen, David Wang, Mikael Knip, Ramnik J Xavier, Herbert W Virgin
Viruses have long been considered potential triggers of autoimmune diseases. Here we defined the intestinal virome from birth to the development of autoimmunity in children at risk for type 1 diabetes (T1D). A total of 220 virus-enriched preparations from serially collected fecal samples from 11 children (cases) who developed serum autoantibodies associated with T1D (of whom five developed clinical T1D) were compared with samples from controls. Intestinal viromes of case subjects were less diverse than those of controls...
July 25, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28639594/viral-aetiology-of-wheezing-in-children-under-five
#12
Prithi Sureka Mummidi, Radha Tripathy, Bhagirathi Dwibedi, Amarendra Mahapatra, Suryakanta Baraha
BACKGROUND & OBJECTIVES: Wheezing is a common problem in children under five with acute respiratory infections (ARIs). Viruses are known to be responsible for a considerable proportion of ARIs in children. This study was undertaken to know the viral aetiology of wheezing among the children less than five years of age, admitted to a tertiary care hospital in eastern India. METHODS: Seventy five children, under the age of five years admitted with wheezing, were included in the study...
February 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28634337/evolutionary-and-network-analysis-of-virus-sequences-from-infants-infected-with-an-australian-recombinant-strain-of-human-parechovirus-type-3
#13
Soren Alexandersen, Tiffanie M Nelson, Jason Hodge, Julian Druce
We present the near complete virus genome sequences with phylogenetic and network analyses of potential transmission networks of a total of 18 Australian cases of human parechovirus type 3 (HPeV3) infection in infants in the period from 2012-2015. Overall the results support our previous finding that the Australian outbreak strain/lineage is a result of a major recombination event that took place between March 2012 and November 2013 followed by further virus evolution and possibly recombination. While the nonstructural coding region of unknown provenance appears to evolve significantly both at the nucleotide and amino acid level, the capsid encoding region derived from the Yamagata 2011 lineage of HPeV3 appears to be very stable, particularly at the amino acid level...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28631594/human-picornaviruses-associated-with-neurological-diseases-and-their-neutralization-by-antibodies
#14
REVIEW
Maria Anastasina, Aušra Domanska, Kaia Palm, Sarah Butcher
Picornaviruses are the most commonly encountered infectious agents in mankind. They typically cause mild infections of the gastrointestinal or respiratory tract, but sometimes also invade the central nervous system. There, they can cause severe diseases with long-term sequelae and even be lethal. The most infamous picornavirus is poliovirus, for which significant epidemics of poliomyelitis were reported from the end of the nineteenth century. A successful vaccination campaign has brought poliovirus close to eradication, but neurological diseases caused by other picornaviruses have increasingly been reported since the late 1990s...
June 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28546477/the-complete-genome-sequence-of-a-human-parechovirus-from-a-child-with-diarrhea-in-china-revealed-intertypic-recombination
#15
Xiaoying Zhao, Chenglin Zhou, Xiaodan Zhang, Wang Li, Xinyu Wan, Yan Wang, Yuming Zeng, Wen Zhang
A human parechovirus (HPeV), CH-ZXY1, was detected in feces from a child with diarrhea. Phylogenetic trees over three different genomic regions revealed discordant topological structures. Recombination analysis indicates that CH-ZXY1 is a recombinant resulting from recombination between HPeV5 and HPeV1, which was confirmed by PCR covering the recombination breakpoint.
May 25, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28527677/human-parechovirus-sepsis-induced-coagulopathy-in-an-infant
#16
Jean-Francois Bonnet, Tara M Connelly, Guillermo H Vega, Alfonso Rodriguez Herrera
No abstract text is available yet for this article.
May 17, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/28524217/-importance-of-enteroviruses-in-neuropaediatrics-from-polioviruses-to-other-enteroviruses
#17
M Cabrerizo, Grupo Para El Estudio de Las Infecciones Por Enterovirus Y Parechovirus Grupo Para El Estudio de Las Infecciones Por Enterovirus Y Parechovirus
Enteroviruses are among the most common human viruses around the world. More than 100 different serotypes that can cause a range of clinical pathologies have been identified, although the most frequent are those that affect the central nervous system, such as aseptic meningitis, encephalitis or paralysis, which in some cases can be very severe or even fatal. In recent years, enterovirus outbreaks associated to new diseases have been reported all over the world, and as a result some serotypes have been considered 'emerging' pathogens...
May 17, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28511987/human-parechovirus-type-3-infection-an-emerging-infection-in-neonates-and-young-infants
#18
REVIEW
Yuta Aizawa, Ryohei Izumita, Akihiko Saitoh
Human parechoviruses (HPeVs) are RNA viruses that have characteristics similar to those of enteroviruses and usually cause mild respiratory or gastrointestinal symptoms. Human parechovirus type 3 (HPeV3), first reported in 2004, is exceptional because it can provoke sepsis and meningoencephalitis leading to neurological sequelae, and even death, in neonates and young infants. Pediatricians and researchers are increasingly aware that HPeV3 is responsible for serious disease in neonates and young infants. Retrospective studies and several reports of epidemics of HPeV3 infection have provided data on epidemiology, clinical symptoms and signs, laboratory findings, and outcomes...
May 13, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28498019/severe-human-parechovirus-type-3-infection-in-adults-associated-with-gastroenteritis-in-their-children
#19
Satoshi Tanaka, Yosuke Kunishi, Mitsuyasu Ota, Ayaka Ono, Natsuki Kanno, Yuichi Kurakami, Takafumi Yanagibashi, Mao Matsubayashi, Yoshiteru Hao, Keisuke Iwabuchi, Fumihiro Oshita, Koichiro Yoshie, Yoshio Kato
No abstract text is available yet for this article.
May 12, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28424887/a-metagenomics-study-for-the-identification-of-respiratory-viruses-in-mixed-clinical-specimens-an-application-of-the-iterative-mapping-approach
#20
Yu-Nong Gong, Shu-Li Yang, Guang-Wu Chen, Yu-Wen Chen, Yhu-Chering Huang, Hsiao-Chen Ning, Kuo-Chien Tsao
Metagenomic approaches to detect viral genomes and variants in clinical samples have various challenges, including low viral titers and bacterial and human genome contamination. To address these limitations, we examined a next-generation sequencing (NGS) and iterative mapping approach for virus detection in clinical samples. We analyzed 40 clinical specimens from hospitalized children diagnosed with acute bronchiolitis, croup, or respiratory tract infections in which virus identification by viral culture or polymerase chain reaction (PCR) was unsuccessful...
July 2017: Archives of Virology
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