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Parechovirus

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https://www.readbyqxmd.com/read/28164489/multiplex-pcr-for-the-detection-of-10-viruses-causing-encephalitis-encephalopathy-and-its-application-to-clinical-samples-collected-from-japanese-children-with-suspected-viral
#1
Ngan T K Pham, Hiroshi Ushijima, Aksara Thongprachum, Quang D Trinh, Pattara Khamrin, Chikako Arakawa, Wakako Ishii, Shoko Okitsu, Shihoko Komine-Aizawa, Satoshi Hayakawa
BACKGROUND: Acute encephalitis is a serious neurological condition having a high mortality rate and affecting both children and adults. This study aimed to develop a multiplex PCR method for the simultaneous screening of clinical samples for the presence of the 10 viruses presently considered as the major viral causes of acute encephalitis/ encephalopathy in Asia. METHODS: Using previously published primers that have been widely used to screen for herpes virus-6, influenza A virus, human parechovirus, herpes simplex viruses 1 and 2, Japanese encephalitis virus, group A rotavirus, enterovirus, adenovirus, and dengue virus in clinical samples, a single-tube multiplex PCR assay was developed and was tested for its sensitivity and specificity...
January 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28134705/cutaneous-manifestations-of-systemic-viral-diseases-in-neonates-an-update
#2
Stephanie A Castillo, Anh Khoa Pham, James G Dinulos
PURPOSE OF REVIEW: Dermatologic findings may be the first signs of a neonatal viral infection. This review provides an update of the diagnostic features and therapies for selected viral illnesses [herpes simplex virus (HSV), varicella zoster virus, enterovirus, and Zika virus] that present with cutaneous manifestations in the neonate. RECENT FINDINGS: HSV DNA polymerase chain reaction of plasma and cerebrospinal fluid, routinely used in the diagnosis of neonatal HSV, may have expanded utility in assessing prognosis and acyclovir therapeutic efficacy...
January 27, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28134479/human-parechovirus-in-infants-an-emerging-virus-in-australia-with-severe-neurodevelopmental-implications
#3
Meghan Jones
No abstract text is available yet for this article.
January 30, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28112349/-correcci%C3%A3-n-al-abstract-del-art%C3%A3-culo-parechovirus-como-agente-etiol%C3%A3-gico-de-meningitis-y-o-sepsis-viral-en-lactantes-de-valentina-guti%C3%A3-rrez-y-cols
#4
(no author information available yet)
No abstract text is available yet for this article.
October 2016: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28081453/intertypic-recombination-of-human-parechovirus-4-isolated-from-infants-with-sepsis-like-disease
#5
Pekka Kolehmainen, Anu Siponen, Teemu Smura, Hannimari Kallio-Kokko, Olli Vapalahti, Anne Jääskeläinen, Sisko Tauriainen
BACKGROUND: Human parechoviruses (HPeVs) (family Picornaviridae), are common pathogens in young children. Despite their high prevalence, research on their genetic identity, diversity and evolution have remained scarce. OBJECTIVES: Complete coding regions of three previously reported HPeV-4 isolates from Finnish children with sepsis-like disease were sequenced in order to elucidate the phylogenetic relationships and potential recombination events during the evolution of these isolates...
January 3, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/27977558/intensive-care-admissions-for-children-with-enterovirus-and-human-parechovirus-infections-in-the-united-kingdom-and-the-republic-of-ireland-2010-2014
#6
Serena Braccio, Melpo Kapetanstrataki, Mike Sharland, Shamez N Ladhani
Enteroviruses and human parechoviruses usually cause mild, self-limiting illnesses in children but can occasionally cause severe disease. During 2010-2014, 104 children in the United Kingdom and the Republic of Ireland were admitted to a pediatric intensive care unit with severe enterovirus and human parechovirus infection; 40% had neurologic symptoms, 20% respiratory failure, 16% cardiac complications and 11% septic shock. Annual number of cases and incidence increased in the 5-year period, from 0.6/1000 pediatric intensive care unit admissions (12 cases) in 2010 to 1...
March 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27940759/human-parechovirus-as-a-cause-of-isolated-pediatric-acute-liver-failure
#7
Amee M Bigelow, John P Scott, Johnny C Hong, David C Cronin, Bernadette E Vitola, Roger A Fons, Tara L Petersen
Among infants, almost half of acute liver failure cases are classified as indeterminate, whereas only a small number of cases show a documented viral infection. We present the first reported case of isolated acute hepatic failure in an infant in the setting of a human parechovirus (HPeV) infection. HPeV also may have been contributory to the posttransplant complication of 2 intussusceptions. This is a 10-month-old girl who presented with only symptoms of fussiness and was noted to have progressive decline in synthetic liver function as well as worsening coagulopathy requiring a liver transplant...
November 2016: Pediatrics
https://www.readbyqxmd.com/read/27925289/seroepidemiology-of-human-parechovirus-types-1-3-and-6-in-yamagata-japan-in-2014
#8
Shizuka Tanaka, Yoko Aoki, Yohei Matoba, Kazue Yahagi, Tsutomu Itagaki, Yoko Matsuzaki, Katsumi Mizuta
To clarify the seroepidemiology of human parechovirus type 1 (HPeV1), 3 and 6, neutralizing antibodies (NT Abs) were measured in 214 serum specimens collected in 2014 in Yamagata, Japan. The seroprevalence against HPeV1 was 100% for all age groups, while that against HPeV3 and HPeV6 among all residents was 79.4% and 66.8%, respectively. The genometric mean titers of NT Abs against HPeV1, 3 and 6 among all residents were 755.2, 255.0 and 55.8, respectively. Our study indicated that HPeV1 is the most prevalent HPeV circulating in Yamagata, followed by HPeV3 and HPeV6...
December 7, 2016: Microbiology and Immunology
https://www.readbyqxmd.com/read/27914285/human-parechovirus-and-enterovirus-initiate-distinct-cns-innate-immune-responses-pathogenic-and-diagnostic-implications
#9
Danielle Fortuna, Ana María Cárdenas, Erin H Graf, Larry A Harshyne, D Craig Hooper, Michael Prosniak, John Shields, Mark T Curtis
BACKGROUND: Human parechovirus (HPeV) and enterovirus (EV) cause a range of human diseases including serious CNS infections. Little is known regarding the immune response to HPeV meningitis compared to EV meningitis or how the immune response to HPeV reflects its pathogenesis. OBJECTIVE: To characterize the innate immune response to HPeV CNS infection in order to increase our understanding of HPeV pathogenesis and possibly help identify HPeV in the clinical setting...
January 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/27905621/-parechovirus-as-etiologic-agent-of-meningitis-and-or-sepsis-like-illness-in-infants
#10
Valentina Gutiérrez, Constanza Martínez-Valdebenito, Luisa Montecinos, Romina Alarcón, Constanza Gárate, Marcela Ferrés
INTRODUCTION: Human parechovirus (HPeV) belongs to the Picornaviridae family and has been described in viral meningoencephalitis and sepsis like illness in infants. Until now, 16 genotypes have been recognized, the most common are HPEV 1, 2 and 3; type 3 is most severe. AIMS: To estimate the frequency of HPEV etiology in viral meningoencephalitis and sepsis in infants and characterize clinical and molecular aspects of infection. METHODS: Between October 2013 and March 2015 we collected CSF samples, plasma, nasopharyngeal swabs and/or stools of patients younger than two years with suspected sepsis and/or viral meningitis...
August 2016: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/27851439/1804-parechovirus-an-elusive-cause-of-neonatal-encephalopathy
#11
Jaime Jump, Ajit Mammen
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27826360/genome-analysis-revealed-novel-genotypes-and-recombination-of-the-human-parechoviruses-prevalent-in-children-in-eastern-china
#12
Xiangyang Zhao, Yongqiang Shi, Yu Xia
BACKGROUND: Human parechovirus (HPeV) is a genus of virus in the family Picornaviridae, having two species A and B. HPeVs are common infectious agents, usually causing mild diarrhea and respiratory disease in young children. RESULTS: Here, we collected and sequenced the near complete genome sequences of 17 novel HPeVs from children with diarrhea in eastern China, which showed significant nucleotide sequence divergence. Phylogenetic analysis based on the complete genomes of these HPeV strains revealed that they belonged to seven different genotypes (including three putative novel genotypes), suggesting that HPeVs showed genotype diversity in this area...
2016: Gut Pathogens
https://www.readbyqxmd.com/read/27826297/lipopolysaccharide-attenuates-induction-of-proallergic-cytokines-thymic-stromal-lymphopoietin-and-interleukin-33-in-respiratory-epithelial-cells-stimulated-with-polyi-c-and-human-parechovirus
#13
Tsang-Hsiung Lin, Chih-Chi Cheng, Hsing-Hao Su, Nan-Chieh Huang, Jih-Jung Chen, Hong-Yo Kang, Tsung-Hsien Chang
Epidemiological studies based on the "hygiene hypothesis" declare that the level of childhood exposure to environmental microbial products is inversely related to the incidence of allergic diseases in later life. Multiple types of immune cell-mediated immune regulation networks support the hygiene hypothesis. Epithelial cells are the first line of response to microbial products in the environment and bridge the innate and adaptive immune systems; however, their role in the hygiene hypothesis is unknown. To demonstrate the hygiene hypothesis in airway epithelial cells, we examined the effect of lipopolysaccharide (LPS; toll-like receptor 4 ligand) on the expression of the proallergic cytokines thymic stromal lymphopoietin (TSLP) and interleukin 33 (IL33) in H292 cells (pulmonary mucoepidermoid carcinoma cells)...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27816019/molecular-detection-of-human-parechovirus-in-under-five-year-old-children-with-gastroenteritis
#14
Massimiliano Bergallo, Ilaria Galliano, Paola Montanari, Martina Rosa Brusin, Clara Gabiano
BACKGROUND: Currently, RT-PCR is used widely and considered to be a convenient, useful, and powerful method for molecular diagnosis, to detect pathogens from clinical specimens. OBJECTIVES: In this work we describe the development of an in-house Real-time Taqman PCR assay for quantification of HPeV in stool specimens. STUDY DESIGNS: A total of 137 fecal specimens previously screened for rotavirus and adenovirus were tested for HPeV virus. RESULTS: A total of 11 out of 137 (8%) episodes of acute gastroenteritis were associated with HPeV genomic detection with median viral load 14678±28927 genomes/mg fecal specimens...
December 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/27749661/a-4-year-study-on-epidemiologic-and-molecular-characteristics-of-human-parechoviruses-and-enteroviruses-circulating-in-children-younger-than-5-years-in-northern-italy
#15
Laura Bubba, Marianna Martinelli, Laura Pellegrinelli, Valeria Primache, Elisabetta Tanzi, Elena Pariani, Sandro Binda
BACKGROUND: Human parechovirus (HPeV) and enterovirus (EV) infections are widespread and can lead to a broad range of symptoms, from the common cold to severe disease (SD). Because of the lack of Italian data, this 4-year retrospective cross-sectional study aimed to investigate the frequency, seasonality and molecular characteristics of EV and HPeV circulating in children younger than 5 years. METHODS: A total of 812 samples were collected from children ≤5 years (56...
January 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27736008/detection-of-gastroenteritis-viruses-among-pediatric-patients-in-hiroshima-prefecture-japan-between-2006-and-2013-using-multiplex-reverse-transcription-pcr-based-assays-involving-fluorescent-dye-labeled-primers
#16
Naoki Shigemoto, Yuri Hisatsune, Yasushi Toukubo, Yukie Tanizawa, Yukie Shimazu, Shinichi Takao, Tomoyuki Tanaka, Mamoru Noda, Shinji Fukuda
Multiplex reverse transcription (RT)-polymerase chain reaction (PCR)-based assays involving fluorescent dye-labeled primers were modified to detect 10 types of gastroenteritis viruses by adding two further assays to a previously developed assay. Then, these assays were applied to clinical samples, which were collected between January 2006 and December 2013. All 10 types of viruses were effectively detected in the multiplex RT-PCR-based assays. In addition, various viral parameters, such as the detection rates and age distributions of each viral type, were examined...
October 13, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27735999/multiplex-rt-pcr-for-rapid-detection-of-viruses-commonly-causing-diarrhea-in-pediatric-patients
#17
Aksara Thongprachum, Pattara Khamrin, Ngan Thi Kim Pham, Sayaka Takanashi, Shoko Okitsu, Hiroyuki Shimizu, Niwat Maneekarn, Satoshi Hayakawa, Hiroshi Ushijima
Multiplex RT-PCR method using five sets of panel primers was developed for the detection of diarrheal viruses, including rotavirus A, B, and C, adenovirus, astrovirus, norovirus GI and GII, sapovirus, Aichi virus, parechovirus, enterovirus, cosavirus, bocavirus, and Saffold virus. The sensitivity of the method was evaluated and tested with 751 fecal specimens collected from Japanese children with acute diarrhea. Several kinds of viruses were detected in 528 out of 751 (70.3%) fecal specimens. Mixed-infection with different viruses in clinical specimens could also be effectively detected...
October 13, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27690140/performance-of-a-real-time-pcr-based-approach-and-droplet-digital-pcr-in-detecting-human-parechovirus-type-3-rna
#18
Yuta Aizawa, Akihide Koyama, Tomohiko Ishihara, Osamu Onodera, Akihiko Saitoh
BACKGROUND: Human parechovirus type 3 (HPeV3) is an emerging virus that causes sepsis and meningoencephalitis in neonates and young infants. Correct diagnosis of HPeV3 infection is critical in determining appropriate management and predicting patients' clinical course. Real-time reverse transcription PCR (RT-PCR) analysis of serum and/or cerebrospinal fluid (CSF) has been used to diagnose HPeV3 infection; however, the assay detection limits have not been fully evaluated. OBJECTIVES: We tested the hypothesis that droplet digital RT-PCR (RT-ddPCR)-a novel technique that precisely quantitates low-copy target genes by diluting and partitioning samples into compartments-increases the detection rate of HPeV3 RNA as compared with real-time RT-PCR...
November 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/27686253/first-detection-of-human-parechovirus-infection-with-diarrhoea-india
#19
Krishna Chaaithanya Itta, Kirti Vittal Ghargi, Shanta Kalal, Tanmayi Patil, Subarna Roy
No abstract text is available yet for this article.
February 2017: Infectious Diseases
https://www.readbyqxmd.com/read/27636724/extreme-hyperferritinemia-in-dizygotic-twins-with-human-parechovirus-3-infection
#20
Dídac Casas-Alba, Antonio Martínez-Monseny, Laura Monfort, Carmen Muñoz-Almagro, María Cabrerizo, Àngela Deyà, Cristian Launes
Human parechovirus-3 has been associated with severe clinical manifestations in infants, such as sepsis-like illness and meningoencephalitis. Nevertheless, the vast majority of patients have a favorable outcome. We report the occurrence of this infection in dizygotic infants with extreme hyperferritinemia and a transient impairment of natural-killer cell cytotoxicity.
September 15, 2016: Pediatric Infectious Disease Journal
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