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Toxoplasmosis gondii

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https://www.readbyqxmd.com/read/28448521/immunization-with-toxoplasma-gondii-peroxiredoxin-1-induces-protective-immunity-against-toxoplasmosis-in-mice
#1
Ragab M Fereig, Yasuhiro Kuroda, Mohamad Alaa Terkawi, Motamed Elsayed Mahmoud, Yoshifumi Nishikawa
To develop a vaccine against Toxoplasma gondii, a vaccine antigen with immune-stimulating activity is required. In the present study, we investigated the immunogenicity and prophylactic potential of T. gondii peroxiredoxin 1 (TgPrx1). The TgPrx1 was detected in the ascitic fluid of mice 6 days postinfection, while specific antibody levels were low in the sera of chronically infected mice. Treatment of murine peritoneal macrophages with recombinant TgPrx1 triggered IL-12p40 and IL-6 production, but not IL-10 production...
2017: PloS One
https://www.readbyqxmd.com/read/28436740/major-immunodominant-region-of-hepatitis-b-virus-core-antigen-as-a-delivery-vector-to-improve-the-immunogenicity-of-the-fusion-antigen-rop2-sag1-multiepitope-from-toxoplasma-gondii-in-mice
#2
Wenhuan Wang, Fangfang Feng, Jinhui Lv, Zixin Xie, Jun Chen, Lifang Zhang, Wenshu Li
To prepare the dominant multiepitope fusion antigen ROP2-SAG1 (RSmultiepitope) from Toxoplasma gondii in a prokaryotic system, the major immunodominant region (MIR) of the human hepatitis B virus core antigen (HBcAg(MIR)) was used as a delivery vector. The gene encoding the RSmultiepitope was inserted into HBcAg(MIR), and rHBcAg(MIR)-RSmultiepitope was prepared, purified, and administered to BALB/c mice through intradermal injection. An indirect enzyme-linked immunosorbent assay analysis based on a multiepitope peptide facilitated the specific differentiation of sera obtained from mice immunized with the rHBcAg(MIR)-RSmultiepitope protein, and high titers (greater than 1:6,400) of specific anti-RSmultiepitope antibodies were obtained...
April 24, 2017: Viral Immunology
https://www.readbyqxmd.com/read/28432838/are-poikilothermic-animals-real-hosts-for-toxoplasma-gondii
#3
Henryka Długońska
The protozoan Toxoplasma gondii is believed to be a common parasite of almost all endothermic animals and humans. However, recent reports of toxoplasmosis in marine mammals raise concern that cold-blooded animals may also be a potential source of T. gondii infection. The article discusses the presence of T. gondii in aquatic and terrestrial poikilothermic animals, which may be important elements in the transmission of the parasite.
2017: Annals of Parasitology
https://www.readbyqxmd.com/read/28426411/toxoplasma-gondii-in-backyard-pigs-seroepidemiology-and-mouse-bioassay
#4
Erika Fernanda Torres Samico-Fernandes, Marcela Fernanda Torres Samico-Fernandes, Pedro Paulo Feitosa de Albuquerque, Jonatas Campos de Almeida, André de Souza Santos, André da Rocha Mota, Orestes Luiz de Souza Neto, Rinaldo Aparecido Mota
The aim of this study was to evaluate the occurrence of Toxoplasma gondii in backyard pigs destined for human consumption in Pernambuco state, Brazil. Blood and tissue samples (liver, heart, brain, lung and diaphragm) were collected from 224 pigs from legal slaughterhouses and tested for T. gondii infection. Antibodies to T. gondii were found in the sera of 37.9% (85/224) by using the immunofluorescence antibody test (cut-off - 1:64). Tissue samples from seropositive pigs were bioassayed in mice. Tissue samples from seropositive pigs and from mice of the bioassay were submitted to histopathology, immunohistochemistry, polymerase chain reaction (PCR) and sequencing; 14...
June 1, 2017: Acta Parasitologica
https://www.readbyqxmd.com/read/28424680/induction-of-protective-immunity-against-toxoplasma-gondii-in-mice-by-nucleoside-triphosphate-hydrolase-ii-ntpase-ii-self-amplifying-rna-vaccine-encapsulated-in-lipid-nanoparticle-lnp
#5
Fangjun Luo, Lina Zheng, Yue Hu, Shuxian Liu, Yan Wang, Zhongkui Xiong, Xin Hu, Feng Tan
RNA-based vaccine represents an irresistible and safe immunization strategy with decreasing theoretical risks of genomic integration and malignant cell transformation. To our knowledge, however, there is no report about development of RNA vaccine against Toxoplasma gondii infection. We have previously demonstrated that the recombinant T. gondii nucleoside triphosphate hydrolase-II (NTPase-II) protein is able to provide protective Th1 cell-mediated immunity against T. gondii. Herein, we evaluated the immunogenic potential of a self-amplifying RNA vaccine-encoding T...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28414523/presence-of-toxoplasma-gondii-in-drinking-water-from-an-endemic-region-in-southern-mexico
#6
Ivonne B Hernandez-Cortazar, Karla Y Acosta-Viana, Eugenia Guzman-Marin, Antonio Ortega-Pacheco, Jose C Segura-Correa, Matilde Jimenez-Coello
Toxoplasmosis can be acquired through the ingestion of contaminated drinking water with oocysts of Toxoplasma gondii, highly resistant to the routinely disinfection processes; based on chlorination commonly used in the water supply industry. The aim of this study was to determine the presence of T. gondii DNA in samples of public drinking water from an endemic region of southern Mexico. In total 74 samples of water (5 L each) were collected from the three well fields (I, II, and III) and 71 independent wells, distributing public drinking water to the city of Merida Yucatan, after passing through the chlorination process...
April 17, 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/28413330/toxoplasmosis-seroprevalence-in-iranian-women-and-risk-factors-of-the-disease-a-systematic-review-and-meta-analysis
#7
REVIEW
Azadeh Mizani, Abbas Alipour, Mehdi Sharif, Shahabeddin Sarvi, Afsaneh Amouei, Azar Shokri, Mohammad-Taghi Rahimi, Seyed Abdollah Hosseini, Ahmad Daryani
BACKGROUND: Toxoplasmosis is caused by an intracellular obligatory parasite, Toxoplasma gondii, and it has global distribution. The purposes of this systematic review and meta-analysis were to evaluate the seroprevalence of toxoplasmosis in Iranian pregnant women, and girls and women of childbearing age, and identify potentially preventable risk factors. METHODS: Between November 2014 and February 2017, nine electronic databases that reported data on the T. gondii seroprevalence in Iranian women were searched...
2017: Tropical Medicine and Health
https://www.readbyqxmd.com/read/28406972/disruption-of-outer-blood-retinal-barrier-by-toxoplasma-gondii-infected-monocytes-is-mediated-by-paracrinely-activated-fak-signaling
#8
Hyun Beom Song, Hyoung-Oh Jun, Jin Hyoung Kim, Young-Ha Lee, Min-Ho Choi, Jeong Hun Kim
Ocular toxoplasmosis is mediated by monocytes infected with Toxoplasma gondii that are disseminated to target organs. Although infected monocytes can easily access to outer blood-retinal barrier due to leaky choroidal vasculatures, not much is known about the effect of T. gondii-infected monocytes on outer blood-retinal barrier. We prepared human monocytes, THP-1, infected with T. gondii and human retinal pigment epithelial cells, ARPE-19, grown on transwells as an in vitro model of outer blood-retinal barrier...
2017: PloS One
https://www.readbyqxmd.com/read/28404997/novel-fitc-labeled-igy-antibody-fluorescence-imaging-toxoplasma-gondii-in-vitro
#9
Mehtap Sert, Rabia Cakir Koc, Yasemin Budama Kilinc
Toxoplasmosis is caused by T. gondii and can create serious health problems in humans and also worldwide economic harm. Because of the clinical and veterinary importance of toxoplasmosis, its timely and accurate diagnosis has a major impact on disease-fighting strategies. T. gondii surface antigen 1 (SAG1), an immunodominant-specific antigen, is often used as a diagnostic tool. Therefore, the aim of this study was the optimization of novel fluorescein isothiocyanate (FITC) labeling of the SAG1-specific IgY antibody to show the potential for immunofluorescence imaging of T...
April 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28403373/different-inoculum-loads-of-toxoplasma-gondii-induce-reduction-of-myenteric-neurons-of-the-rat-colon
#10
Rafael Isolani Ferezin, Suellen Lais Vicentino-Vieira, Marcelo Biondaro Góis, Eduardo José de Almeida Araújo, Gessilda de Alcântara Nogueira de Melo, João Luis Garcia, Débora de Mello Gonçales Sant'Ana
Toxoplasmosis, a disease caused by Toxoplasma gondii, is an important health problem, especially in immunocompromised hosts. T. gondii uses the gut wall as an infection gateway, with tropism for muscular and nervous tissues causing intestinal alterations, including some in the enteric nervous system. This study aims at investigating the colon of rats infected by T. gondii in order to understand how the amount of oocysts influences in myenteric neuronal changes. Sixty Wistar rats (Rattus norvegicus) were divided into six groups...
January 2017: Revista Brasileira de Parasitologia Veterinária, Brazilian Journal of Veterinary Parasitology
https://www.readbyqxmd.com/read/28397205/assessment-of-the-implementation-of-the-infectious-diseases-screening-programmes-among-pregnant-women-in-the-lesser-poland-region-and-comparison-with-similar-programmes-conducted-in-other-european-union-countries
#11
Małgorzata Radoń-Pokracka, Maciej Piasecki, Alicja Lachowska, Sebastian Baczkowski, Joanna Spaczyńska, Magdalena Górecka, Magdalena Nowak, Hubert Huras
OBJECTIVES: The aim of the study was to assess the level of implementation of recommendations of the Ministry of Health regarding infectious disease screening during pregnancy. MATERIAL AND METHODS: The study included 477 patients who were admitted to the delivery room between December 2015 and February 2016. Data on screening test results were collected based on medical records covering the period before the admission. RESULTS: The Human Immunodeficiency Virus (HIV) screening was conducted in 410 (86%)...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28394986/-intramedullary-toxoplasmosis-in-hiv-tuberculosis-co-infected-patient
#12
Giancarlo Pérez-Lazo, Raúl Castillo-Córdova, Julio Maquera-Afaray
The most common clinical presentation of Toxoplasma gondii in HIV patients is encephalitis; however, the intramedullary involvement has been reported in a few cases. We report a case of intramedullary toxoplasmosis in a female patient diagnosed with HIV/tuberculosis co-infection, and history of poor adherence to antiretroviral therapy. The patient developed subacute paraparesis with compromise of sensory function and urinary sphincter. The nuclear magnetic resonance evaluation showed a single intramedullary ring-enhanced lesion at the T-8 level which was solved after an anti-Toxoplasma therapy with trimethoprim/sulfamethoxazole...
February 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28394985/-chagas-disease-affecting-the-central-nervous-system-in-a-patient-with-aids-demonstrated-by-quantitative-molecular-methods
#13
Alberto Fica, Marcia Salinas, María Isabel Jercic, Jeannette Dabanch, Andrés Soto, Sergio Quintanilla, Carlos Flores
Although infrequent, Trypanosoma cruzi reactivation is possible among patients with HIV/AIDS infection that develop a tumor-like or granulomatous lesion in the CNS. We report the case of a 60 years old male patient with HIV/AIDS and low CD4 lymphocytes count with cerebellar symptoms and mild paresis, associated to supra and infratentorial hypodense lesions and positive serology tests both to T. gondii and Trypanosoma cruzi. Empirical therapy against toxoplasmosis was prescribed together with antiretroviral therapy but without a favorable response...
February 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28387529/toxoplasma-gondii-infection-in-farmed-wild-boars-sus-scrofa-in-three-cities-of-northeast-china
#14
Meng-Jie Bai, Yang Zou, Hany M Elsheikha, Jian-Gang Ma, Wen-Bin Zheng, Quan Zhao, Xiao-Xuan Zhang, Xing-Quan Zhu
The apicomplexan protozoan parasite Toxoplasma gondii is a widely distributed etiological agent of foodborne illness. This parasite can cause production losses in livestock and serious disease in humans through consumption of contaminated meat. Pig meat is the most likely source of human infection, and wild boars may play a role in the transmission of T. gondii by serving as a reservoir host. This study aimed to investigate the seroprevalence of antibodies to T. gondii among farmed wild boars in China. In an 11-month survey, a total of 882 serum samples were obtained from farmed wild boars from three cities (Jilin City, Siping City, and Baishan City) in Jilin province, Northeast China and were tested for antibodies specific for T...
April 7, 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/28376902/the-first-isolation-and-molecular-characterization-of-toxoplasma-gondii-from-horses-in-serbia
#15
Ivana Klun, Aleksandra Uzelac, Isabelle Villena, Aurélien Mercier, Branko Bobić, Aleksandra Nikolić, Irena Rajnpreht, Marieke Opsteegh, Dominique Aubert, Radu Blaga, Joke van der Giessen, Olgica Djurković-Djaković
BACKGROUND: Consumption of undercooked or insufficiently cured meat is a major risk factor for human infection with Toxoplasma gondii. Although horsemeat is typically consumed rare or undercooked, information on the risk of T. gondii from infected horse meat to humans is scarce. Here, we present the results of a study to determine the presence of T. gondii infection in slaughter horses in Serbia, and to attempt to isolate viable parasites. METHODS: The study included horses from all regions of Serbia slaughtered at two abattoirs between June 2013 and June 2015...
April 4, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28368078/genotyping-of-toxoplasma-gondii-strain-directly-from-human-csf-samples-of-congenital-toxoplasmosis-clinical-case
#16
Chiara Pagliuca, Gabiria Pastore, Elena Scaglione, Annalisa Migliucci, Giuseppe Maria Maruotti, Annunziata Gaetana Cicatiello, Elena Salvatore, Marco Picardi, Josè Camilla Sammartino, Maria Consiglio Buonocore, Pasquale Martinelli, Emilia Iaccarino, Roberta Colicchio, Paola Salvatore
This report describes a case of congenital toxoplasmosis in a newborn in Southern Italy. A pregnant mother had been admitted at the 20th week of her pregnancy on account of pharyngodynia and laterocervical lymphadenopathy. Although serological testing of the mother's serum documented a seroconversion with positive IgG and IgM anti-Toxoplasma antibodies during II trimester, the woman refused to perform prenatal diagnosis for congenital toxoplasmosis. Fetal ultrasound scan already showed mild asymmetrical triventricular hydrocephaly and cerebral calcifications...
April 3, 2017: New Microbiologica
https://www.readbyqxmd.com/read/28367800/vaccination-with-recombinant-adenovirus-expressing-multi-stage-antigens-of-toxoplasma-gondii-by-the-mucosal-route-induces-higher-systemic-cellular-and-local-mucosal-immune-responses-than-with-other-vaccination-routes
#17
Ting Wang, Huiquan Yin, Yan Li, Lingxiao Zhao, Xiahui Sun, Hua Cong
Toxoplasmosis caused by Toxoplasma gondii, an obligate intracellular protozoan, is a cause of congenital disease and abortion in humans and animals. Various vaccination strategies against toxoplasmosis in rodent models have been used in the past few decades; however, effective vaccines remain a challenge. A recombinant adenovirus vaccine expressing ubiquitin-conjugated multi-stage antigen segments (Ad-UMAS) derived from different life-cycle stages of T. gondii was constructed previously. Here, we compared the immune responses and protection effects in vaccination of mice with Ad-UMAS by five vaccination routes including intramuscular (i...
2017: Parasite: Journal de la Société Française de Parasitologie
https://www.readbyqxmd.com/read/28360866/from-toxoplasmosis-to-schizophrenia-via-nmda-dysfunction-peptide-overlap-between-toxoplasma-gondii-and-n-methyl-d-aspartate-receptors-as-a-potential-mechanistic-link
#18
Guglielmo Lucchese
The present work aims at investigating how Toxoplasma gondii (T. gondii) infection may be linked to N-methyl-d-aspartate receptor (NMDAR) dysfunction in schizophrenia and related disorders and puts forward the hypothesis that immune responses against T. gondii may involve NMDARs. Indeed, the analysis of the protozoan proteome and NMDAR subunits for peptide commonalities shows a massive peptide overlap and supports the possibility that anti-T. gondii immune responses raised during active protozoan infection may cross-react with host NMDARs, determining disruption of neural circuits and cognitive deficits...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28348050/differential-ifn-%C3%AE-and-tnf-%C3%AE-driven-cytokine-response-distinguishes-acute-infection-of-a-metatherian-host-with-toxoplasma-gondii-and-neospora-caninum
#19
Shannon L Donahoe, David N Phalen, Bronwyn M McAllan, Denis O'Meally, Milton M McAllister, John Ellis, Jan Šlapeta
Toxoplasma gondii and Neospora caninum (both Apicomplexa) are closely related cyst-forming coccidian parasites that differ significantly in their host range and ability to cause disease. Unlike eutherian mammals, Australian marsupials (metatherian mammals) have long been thought to be highly susceptible to toxoplasmosis and neosporosis because of their historical isolation from the parasites. In this study, the carnivorous fat-tailed dunnart (Sminthopsis crassicaudata) was used as a disease model to investigate the immune response and susceptibility to infection of an Australian marsupial to T...
March 27, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28344403/toxoplasma-gondii-infection-in-meat-animals-from-africa-systematic-review-and-meta-analysis-of-sero-epidemiological-studies
#20
Aretas Babatoundé Nounnagnon Tonouhewa, Yao Akpo, Philippe Sessou, Camus Adoligbe, Eric Yessinou, Yaovi Gildas Hounmanou, Marc Napoléon Assogba, Issaka Youssao, Souaïbou Farougou
AIM: Toxoplasma gondii is an ubiquitous apicomplexan parasite which causes toxoplasmosis in humans and animals. Felids especially cats are definitive hosts and almost all warm-blooded mammals, including livestock and human can serve as intermediate hosts. Food animals can be reservoirs for T. gondii and act as one of the sources for parasite transmission to humans. The objective of this study is to collect serological data on the prevalence of anti-T. gondii antibody, and risk factors for certain food animals from Africa to provide a quantitative estimate of T...
February 2017: Veterinary World
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