keyword
MENU ▼
Read by QxMD icon Read
search

Toxoplasmosis gondii

keyword
https://www.readbyqxmd.com/read/29221851/ccr5-chemokine-receptor-gene-polymorphisms-in-ocular-toxoplasmosis
#1
Geraldo M de Faria, Christiane M Ayo, Amanda P de Oliveira, Alessandro G Lopes, Fábio B Frederico, Aparecida P Silveira-Carvalho, Mariana Previato, Amanda P Barbosa, Fernando H A Murata, Gildásio Castello de Almeida, Rubens Camargo Siqueira, Luiz C de Mattos, Cinara C Brandão de Mattos
C-C chemokine receptor type 5 (CCR5) is a chemokine receptor that influences the immune response to infectious and parasitic diseases. This study aimed to determine whether the CCR5Δ32 and CCR5 59029 A/G polymorphisms are associated with the development of ocular toxoplasmosis in humans. Patients with positive serology for Toxoplasma gondii were analyzed and grouped as 'with ocular toxoplasmosis' (G1: n=160) or 'without ocular toxoplasmosis' (G2: n=160). A control group (G3) consisted of 160 individuals with negative serology...
December 5, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29218125/the-seroprevalence-and-risk-factors-of-toxoplasmosis-among-female-undergraduate-university-students-in-saudi-arabia
#2
Riyadh A Alzaheb, Osama Al-Amer
Objectives: Toxoplasma gondii (T. gondii) is a serious public health issue, but limited data has been published to date on the seroprevalence of T. gondii infection in Saudi Arabia. Therefore, this study aimed to establish the seroprevalence and risk factors of T. gondii infection using a sample of females enrolled at a university in Northern Saudi Arabia. Methods: Using a cross-sectional research approach, we recruited a convenience sample of 180 healthy females studying at the University of Tabuk between February and June 2016...
November 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/29216783/moving-towards-improved-vaccines-for-toxoplasma-gondii
#3
Yawen Li, Huaiyu Zhou
Toxoplasma gondii is an intracellular parasitic protozoan that infects almost all warm-blooded animals and humans, resulting in threats to public health and economic losses. Despite continuous research efforts, there are still very few effective strategies against toxoplasmosis. In the past few years, numerous vaccination experiments have been performed to control T. gondii infection. Areas covered: In this review, the authors summarize the development of T. gondii vaccines with proper adjuvants, ranging from live or live-attenuated vaccines to protein vaccines, DNA vaccines, epitope vaccines and novel vaccines...
December 8, 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/29216332/voltage-dependent-calcium-channel-signaling-mediates-gabaa-receptor-induced-migratory-activation-of-dendritic-cells-infected-by-toxoplasma-gondii
#4
Sachie Kanatani, Jonas M Fuks, Einar B Olafsson, Linda Westermark, Benedict Chambers, Manuel Varas-Godoy, Per Uhlén, Antonio Barragan
The obligate intracellular parasite Toxoplasma gondii exploits cells of the immune system to disseminate. Upon T. gondii-infection, γ-aminobutyric acid (GABA)/GABAA receptor signaling triggers a hypermigratory phenotype in dendritic cells (DCs) by unknown signal transduction pathways. Here, we demonstrate that calcium (Ca2+) signaling in DCs is indispensable for T. gondii-induced DC hypermotility and transmigration in vitro. We report that activation of GABAA receptors by GABA induces transient Ca2+ entry in DCs...
December 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29203146/toward-detection-of-toxoplasmosis-from-urine-in-mice-using-hydro-gel-nanoparticles-concentration-and-parallel-reaction-monitoring-mass-spectrometry
#5
Hannah E Steinberg, Paul Russo, Noelia Angulo, Raúl Ynocente, Cristina Montoya, Andrea Diestra, Cusi Ferradas, Francesca Schiaffino, Edgar Florentini, Juan Jimenez, Maritza Calderón, Vern B Carruthers, Robert H Gilman, Lance Liotta, Alessandra Luchini
Diagnosis of clinical toxoplasmosis remains a challenge, thus limiting the availability of human clinical samples. Though murine models are an approximation of human response, their definitive infection status and tissue availability makes them critical to the diagnostic development process. Hydrogel mesh nanoparticles were used to concentrate antigen to detectable levels for mass spectrometry. Seven T. gondii isolates were used to develop a panel of potential peptide sequences for detection by parallel reaction monitoring (PRM) mass spectrometry...
December 1, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29202747/seroprevalence-of-toxoplasmosis-and-risk-factors-of-toxoplasma-gondii-infection-among-pregnant-women-in-sri-lanka-a-cross-sectional-study
#6
Devika Iddawela, Sanura Malinda Pallegoda Vithana, Chathura Ratnayake
BACKGROUND: Toxoplasma gondii is an intracellular protozoan infecting humans and animals. Infection in adults usually causes mild disease but greater importance lies in preventing transplacental transmission which can cause major foetal anomalies and is vital to identify infection in pregnancy. Research on this regard in Sri Lanka is scarce and would be beneficial in developing antenatal care strategies for improved foetal outcome. METHODS: A random sample of 536 pregnant women attending antenatal care in Teaching Hospital Peradeniya from 2010 to 2013 was recruited for this study...
December 4, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29202176/distribution-and-evolution-of-peroxisomes-in-alveolates-apicomplexa-dinoflagellates-ciliates
#7
Ann-Kathrin Ludewig-Klingner, Victoria Michael, Michael Jarek, Henner Brinkmann, Jörn Petersen
The peroxisome was the last organelle to be discovered and five decades later it is still the Cinderella of eukaryotic compartments. Peroxisomes have a crucial role in the detoxification of reactive oxygen species, the beta-oxidation of fatty acids and the biosynthesis of etherphospholipids, and they are assumed to be present in virtually all aerobic eukaryotes. Apicomplexan parasites including the malaria and toxoplasmosis agents were decribed as the first group of mitochondriate protists devoid of peroxisomes...
November 29, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/29201121/assessment-of-toxoplasma-seropositivity-in-children-suffering-from-anxiety-disorders
#8
Shahla Afsharpaiman, Mohammad Hossein Khosravi, Mojtaba Mahmoodinejad, Shahnaz Shirbazoo, Susan Amirsalari, Mohammad Torkaman, Shokoofeh Radfar
Objective: This study aimed to assess the seroprevalence of Toxoplasma gondii in children with anxiety disorders. Materials & Methods: This cross-sectional study was conducted between Sep 2012 and May 2013 in Pediatrics Clinic of Baqiyatallah Hospital, Tehran, Iran. Children were assessed clinically. Diagnosis of patients with anxiety disorders was based on DSM-4 system, performed by child psychiatrist. Then their anti-Toxoplasma antibodies were measured. A questionnaire was verbally administered to all individuals' parents including demographic information and questions about life style, family history, medical history, economic situation, residence, nutritional patterns and contact with animals...
2017: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/29200930/survey-on-synergism-effect-of-ketotifen-in-combination-with-pyrimethamine-in-treatment-of-acute-murine-toxoplasmosis
#9
Mahbobeh Montazeri, Kian Rezaei, Mohammad Ali Ebrahimzadeh, Mehdi Sharif, Shahabeddin Sarvi, Ehsan Ahmadpour, Mohammad Taghi Rahimi, Abdol Satar Pagheh, Saeed Mehrzadi, Ahmad Daryani
Background: Standard treatment of toxoplasmosis is accompanied by severe side effects and low tolerability; accordingly, alternative medicines are critically needed. Ketotifen (KET) as a cell membrane stabilizer could be an appropriate inhibitor of Toxoplasma gondii (T. gondii) parasite entrance into the host cells. Therefore, the focus of current study is characterization of the anti-Toxoplasma activity of KET in the acute phase of toxoplasmosis in murine model as pre-treatment and post-treatment (before and after infection with RH strain)...
2017: Tropical Medicine and Health
https://www.readbyqxmd.com/read/29200288/novel-molecules-to-treat-chronic-central-nervous-system-toxoplasmosis
#10
Sandhya Kortagere
A major challenge in treating toxoplasmosis in immunocompromised patients is lack of therapeutic agents to clear chronic infection and stop the recrudescence of infection after therapy. CDKP1 has emerged as a novel target for treating chronic infections and eliminating latent bradyzoites in the brain. In a mouse model of toxoplasmosis, pyrazolopyrimidine inhibitors of Toxoplasma gondii CDPK1 demonstrated in vitro and in vivo efficacy.
December 4, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29197989/direct-genetic-characterization-of-toxoplasma-gondii-from-clinical-samples-from-denmark-not-only-genotypes-ii-and-iii
#11
P Jokelainen, J-B Murat, H V Nielsen
Genetic variation within Toxoplasma gondii can have both clinical and epidemiological significance, while the genotypes circulating in many parts of the world, including the Nordic country Denmark, are still unknown. We genetically characterized T. gondii strains that had been detected in human clinical samples in Denmark in 2011-2016. Samples that had tested positive for T. gondii DNA and had a quantification cycle value <33 were included in this study and subjected to direct genetic characterization of T...
December 3, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29193137/fatal-toxoplasmosis-in-a-southern-muriqui-brachyteles-arachnoides-from-s%C3%A3-o-paulo-state-brazil-pathological-immunohistochemical-and-molecular-characterization
#12
Stéfanie Vanessa Santos, Hilda F J Pena, Mauricio T Gomes, Rodrigo H F Teixeira, Cristina T Kanamura, Josué Diaz-Delgado, Solange M Gennari, José Luiz Catão-Dias
We report the pathological, immunohistochemical, and molecular features of fatal acute systemic toxoplasmosis in an adult, female, free-living southern muriqui (Brachyteles arachnoides) from São Paulo state, Brazil. PCR-RFLP genotyping analysis identified the #21 genotype of Toxoplasma gondii. This represents the first report of acute toxoplasmosis involving this genotype in humans and animals.
November 29, 2017: Journal of Medical Primatology
https://www.readbyqxmd.com/read/29191253/the-calcium-dependent-protein-kinase-1-from-toxoplasma-gondii-as-target-for-structure-based-drug-design
#13
Emily M Cardew, Christophe L M J Verlinde, Ehmke Pohl
The apicomplexan protozoan parasites include the causative agents of animal and human diseases ranging from malaria (Plasmodium spp.) to toxoplasmosis (Toxoplasma gondii). The complex life cycle of T. gondii is regulated by a unique family of calcium-dependent protein kinases (CDPKs) that have become the target of intensive efforts to develop new therapeutics. In this review, we will summarize structure-based strategies, recent successes and future directions in the pursuit of specific and selective inhibitors of T...
December 1, 2017: Parasitology
https://www.readbyqxmd.com/read/29187938/review-of-toxoplasmosis-in-morocco-seroprevalence-and-risk-factors-for-toxoplasma-infection-among-pregnant-women-and-hiv-infected-patients
#14
REVIEW
Majda Laboudi
Toxoplasmosis is a disease caused by a protozoal parasite: Toxoplasma gondii. This infection can cause severe illness when the organism is contracted congenitally or when it is reactivated in immunosuppressed people. In this paper we review for the first time prevalence and risk factors of T. gondii among pregnant women and HIV-infected adults in Morocco. A systematic review methodology was used to consult three databases: Pub Med, Science Direct and Google Scholar dated until 2015, regarding prevalence data and risk factors of infection among pregnant women and people living with HIV...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29179785/toxoplasma-gondii-reorganizes-the-host-cell-architecture-during-spontaneous-cyst-formation-in-vitro
#15
T C Paredes-Santos, E S Martins-Duarte, W de Souza, M Attias, R C Vommaro
Toxoplasma gondii is an intracellular protozoan parasite that causes toxoplasmosis, a prevalent infection related to abortion, ocular diseases and encephalitis in immuno-compromised individuals. In the untreatable (and life-long) chronic stage of toxoplasmosis, parasitophorous vacuoles (PVs, containing T. gondii tachyzoites) transform into tissue cysts, containing slow-dividing bradyzoite forms. While acute-stage infection with tachyzoites involves global rearrangement of the host cell cytoplasm, focused on favouring tachyzoite replication, the cytoplasmic architecture of cells infected with cysts had not been described...
November 28, 2017: Parasitology
https://www.readbyqxmd.com/read/29177397/-not-everything-is-zika-congenital-toxoplasmosis-still-prevalent-in-colombia
#16
Jorge L Alvarado-Socarras, Keyla Meneses-Silvera, Andrea Carolina Zarate-Vergara, Carlos Guerrero-Gomez, Alfonso J Rodriguez-Morales
Congenital toxoplasmosis continues to be a public health threat. Even existing guidelines, publicly known, its implementation and lack of appropriate interpretation of serological tests in pregnancy is often observed. This leds to failure in opportunities for positive and known interventions to decrease the fetal risk due to Toxoplasma gondii infection. We reported herein a case series, with variable neurological and systemic compromise (respiratory distress, hepatosplenomegaly, enterocolitis, brain calcifications, thrombocytopenia, ascites, shock), even fatal, calling for awareness about the fact that despite the Zika epidemics in 2015-2016 in Brazil, Colombia and other countries, precisely toxoplasmosis, is a differential diagnosis still prevalent in these territories, that can leds to severe consequences, with neurological disability and risk of ocular damage, even lately...
April 2017: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/29173620/loop-mediated-isothermal-amplification-lateral-flow-dipstick-lamp-lfd-to-detect-toxoplasma-gondii-oocyst-in-ready-to-eat-salad
#17
Marco Lalle, Alessia Possenti, Jitender P Dubey, Edoardo Pozio
The apicomplexan parasite Toxoplasma gondii is the causative agent of toxoplasmosis, a foodborne zoonosis with a global distribution and estimated to cause up to 20% of the total foodborne disease burden in Europe. Association between T. gondii infection and the consumption of unwashed raw fruits and vegetables contaminated with oocysts has been reported and the increasing habit to eat pre-washed ready-to-eat salads poses a new potential risk for consumers. It is therefore important to trace the occurrence of potential contamination with this parasite to guarantee the safety of ready-to-eat vegetables...
April 2018: Food Microbiology
https://www.readbyqxmd.com/read/29170005/high-heterogeneity-mixed-infections-and-new-genotypes-in-human-congenital-toxoplasmosis-cases-in-the-mega-metropolis-of-central-mexico
#18
Claudia Patricia Rico-Torres, Luis Fernando Valenzuela-Moreno, Héctor Luna-Pastén, Ricardo Figueroa-Damián, Valeria Gómez-Toscano, Lorena Hernández-Delgado, Mónica Patricia Escobedo-Torres, Dolores Correa
Mexico presents high prevalence of Toxoplasma gondii infection, including the congenital form, but there are few data about the genetic diversity of the parasite, so we attempted parasite isolation and genotyping in nine mother/children pairs with congenital toxoplasmosis (CT), living in the Valley of Mexico, who were part of a 30 cases cohort that started 12 years ago. They were recruited through research projects which included pre- and postnatal screening of congenital infections or directly CT, and cases referred to INP for management because they had clinical abnormalities...
November 20, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29163509/downregulated-il-21-response-and-t-follicular-helper-cell-exhaustion-correlate-with-compromised-cd8-t-cell-immunity-during-chronic-toxoplasmosis
#19
Magali M Moretto, SuJin Hwang, Imtiaz A Khan
CD8 T cells are important for maintaining the chronicity of Toxoplasma gondii infection. In a T. gondii encephalitis susceptible model, we recently demonstrated that CD4 T cells play an essential helper role in the maintenance of the effector response and CD8 T cell dysfunctionality was linked to CD4 T cell exhaustion. However, CD4 T cells are constituted of different subsets with various functions and the population(s) providing help to the CD8 T cells has not yet been determined. In the present study, T follicular helper cells (Tfh), which are known to be essential for B cell maturation and are one of the main sources of IL-21, were significantly increased during chronic toxoplasmosis...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29158278/characterization-of-plasmodium-atg3-atg8-interaction-inhibitors-identifies-novel-alternative-mechanisms-of-action-in-toxoplasma-gondii
#20
Joseph M Varberg, Kaice A LaFavers, Gustavo Arrizabalaga, William J Sullivan
Protozoan parasites, including the apicomplexan pathogens Plasmodium falciparum (malaria) and Toxoplasma gondii (toxoplasmosis) infect millions of people world-wide and represent a major human disease burden. Despite their prevalence, therapeutic strategies to treat these infections remain limited and are threatened by the emergence of drug resistance, highlighting the need for the identification of novel drug targets. Recently, homologues of the core autophagy proteins, including Atg8 and Atg3, were identified in many protozoan parasites...
November 20, 2017: Antimicrobial Agents and Chemotherapy
keyword
keyword
42533
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"