keyword
MENU ▼
Read by QxMD icon Read
search

Toxoplasmosis gondii

keyword
https://www.readbyqxmd.com/read/28735668/ovine-toxoplasmosis-a-new-look-at-its-pathogenesis
#1
J Benavides, M Fernández, P Castaño, M C Ferreras, L Ortega-Mora, V Pérez
Conditions causing reproductive failure are a significant concern in the livestock industry, and amongst these, ovine toxoplasmosis is one of the most important. Despite decades of research, there remain gaps in knowledge about this disease, especially regarding the pathogenesis of abortion in sheep. As for other diseases causing ovine abortion, such as chlamydial abortion or border disease, the consequences of infection with Toxoplasma gondii depend largely on the stage of gestation, but the mechanisms involved are not well understood...
July 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28732033/spatial-and-simultaneous-representative-seroprevalence-of-anti-toxoplasma-gondii-antibodies-in-owners-and-their-domiciled-dogs-in-a-major-city-of-southern-brazil
#2
Aline do Nascimento Benitez, Felippe Danyel Cardoso Martins, Marcelle Mareze, Nelson Jessé Rodrigues Santos, Fernanda Pinto Ferreira, Camila Marinelli Martins, João Luis Garcia, Regina Mitsuka-Breganó, Roberta Lemos Freire, Alexander Welker Biondo, Italmar Teodorico Navarro
Toxoplasmosis, caused by Toxoplasma gondii, has traditionally been considered an important water and foodborne protozoonosis with important public health considerations. Although felids play a well-established role as definitive hosts, canine epidemiological involvement in the parasite's life cycle remains questionable and controversial. The increasing closeness of the human-dog bond, particularly seen in urban settings, has been recognized as a historically unprecedented worldwide movement. Sharing daily lives in the same households, dogs may be exposed to similar associated risks of T...
2017: PloS One
https://www.readbyqxmd.com/read/28720125/profiling-of-the-perturbed-metabolomic-state-of-mouse-spleen-during-acute-and-chronic-toxoplasmosis
#3
Xiao-Qing Chen, Chun-Xue Zhou, Hany M Elsheikha, Shuai He, Gui-Xue Hu, Xing-Quan Zhu
BACKGROUND: Toxoplasma gondii, a common opportunistic protozoan, is a leading cause of illness and mortality among immunosuppressed individuals and during congenital infections. Current therapeutic strategies for toxoplasmosis are not fully effective at curtailing disease progression in these cases. Given the parasite ability to influence host immunity and metabolism, understanding of the metabolic alterations in the host's immune organs during T. gondii infection may enhance the understanding of the molecular mechanisms that define the pathophysiology of T...
July 18, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28719949/seroprevalence-of-toxoplasmosis-with-elisa-and-rapid-diagnostic-test-among-residents-in-gyodong-do-inchon-city-korea-a-four-year-follow-up
#4
Yeong Hoon Kim, Ji Hoo Lee, Seong Kyu Ahn, Tong-Soo Kim, Sung-Jong Hong, Chom-Kyu Chong, Hye-Jin Ahn, Ho-Woo Nam
ELISA has been used for the diagnosis of toxoplasmosis, but it is being gradually replaced by a rapid diagnostic test (RDT). We compared and analyzed ELISA and RDT results using the sera collected during 4 consecutive years from residents of Gyodong-do (Island), Incheon-city, Korea. Sera from 921, 993, 940, and 838 adult residents were collected on a yearly basis (2010-2013). ELISA was performed by using a crude extract of T. gondii RH strain antigen and IgG/IgM RDT mounted with recombinant fragment of major surface antigen (SAG1), GST-linker-SAG1A, were applied to the sera...
June 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/28719288/evaluation-of-the-protective-effect-of-deoxyribonucleic-acid-vaccines-encoding-granule-antigen-2-and-5-against-acute-toxoplasmosis-in-balb-c-mice
#5
Xiao Teng Ching, Mun Yik Fong, Yee Ling Lau
AbstractToxoplasma gondii infects a broad range of warm-blooded hosts, including humans. Important clinical manifestations include encephalitis in immunocompromised patients as well as miscarriage and fetal damage during early pregnancy. Toxoplasma gondii dense granule antigen 2 and 5 (GRA2 and GRA5) are essential for parasitophorous vacuole development of the parasite. To evaluate the potential of GRA2 and GRA5 as recombinant DNA vaccine candidates, these antigens were cloned into eukaryotic expression vector (pcDNA 3...
June 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28713605/diarrhea-as-a-presenting-symptom-of-disseminated-toxoplasmosis
#6
Matthew Glover, Zhouwen Tang, Robert Sealock, Shilpa Jain
Disseminated toxoplasmosis is uncommon in both immunocompetent and immunocompromised hosts with gastrointestinal involvement being rarely described. We report a case of disseminated gastrointestinal toxoplasmosis in an immunocompromised man who presented with one month of diarrhea and abdominal pain. Imaging showed thickening of the ascending colon and cecum. Esophagogastroduodenoscopy and colonoscopy biopsies revealed Toxoplasma gondii, confirmed by immunostain. Symptoms completely resolved following treatment with pyrimethamine, sulfadiazine, and leucovorin...
2017: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/28710007/chronic-toxoplasmosis-treatment-with-diphenyl-diselenide-in-infected-mice-modulates-the-activity-of-purinergic-enzymes-and-reduces-inflammation-in-spleen
#7
Pedro H Doleski, Maura V Ten Caten, Daniela F Passos, Lívia G Castilhos, Daniela B R Leal, Vanessa S Machado, Nathieli B Bottari, Fernanda F Vogel, Ricardo E Mendes, Aleksandro Schafer da Silva
Toxoplasma gondii, an intracellular protozoan, may cause chronic infection in the brain tissue of the host inducing a systemic pro-inflammatory profile. Chronic infections can induce numerous physiological changes, such as alterations in the immune and oxidative profiles. Diphenyl diselenide (PhSe)2, an organoselenium compound, has shown antioxidant and immunomodulatory activities in recent studies. So, the aim of this study was to investigate the activity of purinergic enzymes and reactive oxygen species (ROS) in serum and spleen of mice chronically infected by T...
July 11, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28706936/impact-of-the-host-on-toxoplasma-stage-differentiation
#8
REVIEW
Carsten G K Lüder, Taibur Rahman
The unicellular parasite Toxoplasma gondii infects warm-blooded animals and humans, and it is highly prevalent throughout the world. Infection of immunocompetent hosts is usually asymptomatic or benign but leads to long-term parasite persistence mainly within neural and muscular tissues. The transition from acute primary infection towards chronic toxoplasmosis is accompanied by a developmental switch from fast replicating and metabolically highly active tachyzoites to slow replicating and largely dormant bradyzoites within tissue cysts...
June 22, 2017: Microbial Cell
https://www.readbyqxmd.com/read/28706518/immunization-with-toxoplasma-gondii-gra17-deletion-mutant-induces-partial-protection-and-survival-in-challenged-mice
#9
Jin-Lei Wang, Hany M Elsheikha, Wei-Ning Zhu, Kai Chen, Ting-Ting Li, Dong-Mei Yue, Xiao-Xuan Zhang, Si-Yang Huang, Xing-Quan Zhu
Toxoplasmosis remains a world-threatening disease largely because of the lack of a fully effective vaccine. Here, we created a ΔGRA17 mutant by disrupting the virulence factor GRA17 using CRISPR-Cas9 method. Then, we tested whether ΔGRA17 tachyzoites can be used as a live-attenuated vaccine against acute, chronic, and congenital Toxoplasma gondii infection in mice. Immune response evoked by ΔGRA17 immunization suggested a sequential Th1 and Th2 T cell response, indicated by high levels of Th1 and a mixed Th1/Th2 cytokines at 28 and 70 days after immunization, respectively...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28697873/toxoplasma-gondii-seroprevalence-and-association-with-equine-protozoal-myeloencephalitis-a-case-control-study-of-californian-horses
#10
K E James, W A Smith, A E Packham, P A Conrad, N Pusterla
While toxoplasmosis is not commonly considered a clinical disease of equines, previous seroprevalence studies have reported differing background rates of Toxoplasma gondii infection in horses globally. The objective of this study was to evaluate possible associations between T. gondii seroprevalence and clinical signs of equine protozoal myeloencephalitis (EPM) in horses. Using a case-control study design, 720 Californian horses with neurologic signs compatible with EPM were compared to healthy, non-neurologic horses for the presence of T...
June 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28697821/the-first-detection-of-toxoplasma-gondii-dna-in-environmental-air-samples-using-gelatine-filters-real-time-pcr-and-loop-mediated-isothermal-lamp-assays-qualitative-and-quantitative-analysis
#11
Anna Lass, Beata Szostakowska, Krzysztof Korzeniewski, Panagiotis Karanis
Toxoplasma gondii infections are acquired through the ingestion of oocysts present in the environment. However, there is no data about their occurrence in the air or about airborne transmission of these infections. In the present paper, we report on the identification of T. gondii using rapid molecular detection methods, supported by microscopic analysis, in environmental air samples. A total of 71 samples were collected, using gelatine filters, from kitchen gardens, recreational areas and sandpits located in northern and north-eastern Poland...
July 12, 2017: Parasitology
https://www.readbyqxmd.com/read/28697120/association-of-parasite-load-levels-in-amniotic-fluid-with-clinical-outcome-in-congenital-toxoplasmosis
#12
Lidia Yamamoto, Lília S Targa, Laura M Sumita, Paulo T Shimokawa, Jonatas C Rodrigues, Kelly A Kanunfre, Thelma S Okay
OBJECTIVE: To correlate neonatal and infant clinical outcome with parasite load in amniotic fluid (AF). METHODS: We conducted a retrospective cohort study of 122 children whose mothers had toxoplasmosis during pregnancy. The children were monitored from birth to 12 months old. Stored AF samples were obtained at maternal diagnosis and tested by quantitative polymerase chain reaction. Gestational age at maternal infection, quantitative polymerase chain reaction results, neonatal anti-Toxoplasma gondii immunoglobulin (Ig) M, and clinical outcome at 12 months were correlated...
July 7, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28696589/in-vitro-activity-of-the-interaction-between-taxifolin-dihydroquercetin-and-pyrimethamine-against-toxoplasma-gondii
#13
Daniel A Abugri, William H Witola, Albert E Russell, Roberta M Troy
Toxoplasmosis is one of the most neglected zoonotic foodborne parasitic diseases that cause public health and socio-economic concern worldwide. The current drugs used for the treatment of toxoplasmosis have been identified to have clinical limitations. Hence, new drugs are urgently needed to eradicate T.gondii infections globally. Here, an in vitro anti-Toxoplasma gondii activity of taxifolin (dihydroquercetin) and dihydrofolate inhibitor (pyrimethamine) alone and in combination with a fixed concentration of pyrimethamine were investigated against the rapidly proliferating T...
July 11, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28695827/experimental-toxoplasmosis-in-japanese-quails-coturnix-coturnix-japonica
#14
Ayhan Atasever, Cahit Babür, Abdullah İnci, Görkem Ekebaş, Anıl İça
OBJECTIVE: In this study, forming of experimental toxoplasmosis in quails; clinical, pathological, and serological determination of tissue lesions and bioassay techniques, which were aimed to compare them and determine pathogenesis. METHODS: A total of 120 one-year-old female quails (Coturnix coturnix japonica) were divided into oral infection, parenteral infection, and control groups. The oral group was infected with 0.5 ml inoculum suspension containing 106 tachyzoites of Toxoplasma gondii, whereas the control group was administered 0...
June 2017: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/28694187/a-more-sensitive-efficient-and-iso-17025-validated-magnetic-capture-real-time-pcr-method-for-the-detection-of-archetypal-toxoplasma-gondii-strains-in-meat
#15
Ignacio Gisbert Algaba, Manon Geerts, Malgorzata Jennes, Wim Coucke, Marieke Opsteegh, Eric Cox, Pierre Dorny, Katelijne Dierick, Stéphane De Craeye
Toxoplasma gondii is a globally prevalent, zoonotic parasite of major importance to public health. Various indirect and direct methods can be used for the diagnosis of toxoplasmosis. Whereas serological tests are useful to prove contact with the parasite has occurred, the actual presence of the parasite in the tissues of a seropositive animal is not demonstrated. For this, a bioassay is still the reference method. As an alternative, various PCR methods have been developed, but due to the limited amount of sample that can be tested, combined with a low tissue cyst density, those have proved to be insufficiently sensitive...
July 8, 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28693432/seroprevalence-and-risk-factors-of-toxoplasma-gondii-infection-in-pregnant-women-from-bobo-dioulasso-burkina-faso
#16
Sanata Bamba, Mamoudou Cissé, Ibrahim Sangaré, Adama Zida, Souleymane Ouattara, Robert T Guiguemdé
BACKGROUND: Toxoplasmosis is one of the common worldwide parasitic zoonosis due to Toxoplasma gondii (T. gondii). Toxoplasmosis during pregnancy can result in fetal and neonatal death or various congenital defects. The aim of this study was to assess the seroprevalence and risk factors of T. gondii infection in pregnant women following antenatal care (ANC) services at Bobo Dioulasso. METHODS: A cross-sectional study was conducted enrolling a sample of 316 pregnant women attending ANC at centers for maternal and child health of Bobo-Dioulasso town from March 2013 to February 2014...
July 11, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28692640/congenital-toxoplasmosis-in-austria-prenatal-screening-for-prevention-is-cost-saving
#17
Andrea-Romana Prusa, David C Kasper, Larry Sawers, Evelyn Walter, Michael Hayde, Eileen Stillwaggon
BACKGROUND: Primary infection of Toxoplasma gondii during pregnancy can be transmitted to the unborn child and may have serious consequences, including retinochoroiditis, hydrocephaly, cerebral calcifications, encephalitis, splenomegaly, hearing loss, blindness, and death. Austria, a country with moderate seroprevalence, instituted mandatory prenatal screening for toxoplasma infection to minimize the effects of congenital transmission. This work compares the societal costs of congenital toxoplasmosis under the Austrian national prenatal screening program with the societal costs that would have occurred in a No-Screening scenario...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28689893/evaluation-of-serological-and-molecular-tests-used-to-identify-toxoplasma-gondii-infection-in-pregnant-women-attended-in-a-public-health-service-in-s%C3%A3-o-paulo-state-brazil
#18
Fernando Henrique Antunes Murata, Marina Neves Ferreira, Vera Lucia Pereira-Chioccola, Lígia Cosentino Junqueira Franco Spegiorin, Cristina da Silva Meira-Strejevitch, Ricardo Gava, Aparecida Perpétuo Silveira-Carvalho, Luiz Carlos de Mattos, Cinara Cássia Brandão de Mattos
Toxoplasmosis during pregnancy can have severe consequences. The use of sensitive and specific serological and molecular methods is extremely important for the correct diagnosis of the disease. We compared the ELISA and ELFA serological methods, conventional PCR (cPCR), Nested PCR and quantitative PCR (qPCR) in the diagnosis of Toxoplasma gondii infection in pregnant women without clinical suspicion of toxoplasmosis (G1=94) and with clinical suspicion of toxoplasmosis (G2=53). The results were compared using the Kappa index, and the sensitivity, specificity, positive predictive value and negative predictive value were calculated...
June 17, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28688333/toxoplasmosis-accelerates-acquisition-of-epilepsy-in-rats-undergoing-chemical-kindling
#19
Jalal Babaie, Mohammad Sayyah, Samira Choopani, Tara Asgari, Majid Golkar, Kourosh Gharagozli
Epilepsy is one of the most common neurologic disorders worldwide with no distinguishable cause in 60% of patients. One-third of the world population has been infected with Toxoplasma gondii. This intracellular parasite has high tropism for excitable cells including neurons. We assessed impact of acute and chronic T. gondii infection on epileptogenesis in pentylenetetrazole (PTZ) kindling model in male rats. T. gondii cysts were administered to rats by intraperitoneal (i.p.) injection. The presence of T. gondii cysts in the brain of rats was verified by hematoxylin-eosin staining...
June 24, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28682771/seroprevalence-and-risk-factors-of-neospora-spp-and-toxoplasma-gondii-infections-among-horses-and-donkeys-in-nigeria-west-africa
#20
Eva Bártová, Kamil Sedlák, Kateřina Kobédová, Marie Budíková, Yakubu Joel Atuman, Joshua Kamani
Neospora spp. and Toxoplasma gondii are considered to be a globally distributed parasites affecting wide range of warm-blooded animals. Neosporosis has caused clinical illness in horses and consumption of horse meat has been epidemiologically linked to clinical toxoplasmosis in humans. This study was conducted to determine Neospora spp. and T. gondii antibodies and risk factors of infection in horses and donkeys from three states of Nigeria. A total of 144 samples were collected from clinically healthy animals (120 horses and 24 donkeys)...
September 26, 2017: Acta Parasitologica
keyword
keyword
42533
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"