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adipocyte tissue macrophage

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https://www.readbyqxmd.com/read/29773671/targeted-inhibition-of-cd74-attenuates-adipose-cox-2-mif-mediated-m1-macrophage-polarization-and-retards-obesity-related-adipose-tissue-inflammation-and-insulin-resistance
#1
Pei-Chi Chan, Ting-Ni Wu, Ying-Chuan Chen, Chieh-Hua Lu, Martin Wabitsch, Yu-Feng Tian, Po-Shiuan Hsieh
Adipose tissue (AT) inflammation is crucial to the development of obesity-associated insulin resistance. Our aim was to investigate the contribution of COX-2/MIF-mediated crosstalk between hypertrophic adipocytes and macrophages to the etiology of AT inflammation and involvement of CD74 using human SGBS adipocytes, THP-1 macrophages and mice fed a high-fat (HF) diet. The MIF and CD74 mRNA levels in the adipocytes and SVCs (stromal vascular cells) of white fat were highly correlated with body weight, HOMA-IR and adipose macrophage marker expression levels, especially those in SVCs...
May 17, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29768045/mfe-hi-adipose-tissue-macrophages-compensate-for-tissue-iron-pertubations-in-mice
#2
Merla J Hubler, Keith M Erikson, Arion J Kennedy, Alyssa H Hasty
Resident adipose tissue macrophages (ATMs) play multiple roles to maintain tissue homeostasis, such as removing excess FFAs and regulation of extracellular matrix. The phagocytic nature and oxidative resiliency of macrophages not only allows them to function as innate immune cells but also to respond to specific tissue needs, such as iron homeostasis. MFehi ATMs are a subtype of resident ATMs that we recently identified to have twice the intracellular iron content as other ATMs and elevated expression of iron handling genes...
May 16, 2018: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29763526/extra-virgin-olive-oil-with-natural-phenolic-content-exerts-an-anti-inflammatory-effect-in-adipose-tissue-and-attenuates-the-severity-of-atherosclerotic-lesions-in-ldlr-leiden-mice
#3
Amparo Luque-Sierra, Leticia Alvarez-Amor, Robert Kleemann, Franz Martín, Lourdes M Varela
SCOPE: We evaluated the effect of olive oils with different phenolic content in high-fat diets (HFDs) on hypertrophy and inflammation in adipose tissue and associated atherosclerosis, in the context of obesity. METHODS AND RESULTS: We used Ldlr-/-.Leiden mice fed three different HFDs for 32 weeks and compared them with mice fed the standard low-fat diet (LFD). The different fats provided in the HFDs were: lard (HFD-L), extra-virgin olive oil (79 mg kg-1 of phenolic compounds, HFD-EVOO), or extra-virgin olive oil rich in phenolic compounds (444mg kg-1 of phenolic compounds, HFD-OL)...
May 15, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29762555/global-transcriptome-analysis-identifies-weight-regain-induced-activation-of-adaptive-immune-responses-in-white-adipose-tissue-of-mice
#4
D S Kyung, H R Sung, Y J Kim, K D Kim, S Y Cho, J H Choi, Y-H Lee, I Y Kim, J K Seong
OBJECTIVE: Studies have indicated that weight regain following weight loss predisposes obese individuals to metabolic disorders; however, the molecular mechanism of this potential adverse effect of weight regain is not fully understood. Here we investigated global transcriptome changes and the immune response in mouse white adipose tissue caused by weight regain. DESIGN: We established a diet switch protocol to compare the effects of weight regain with those of weight gain without precedent weight loss, weight loss maintenance and chow diet...
December 7, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29760084/distinct-macrophage-populations-direct-inflammatory-versus-physiological-changes-in-adipose-tissue
#5
David A Hill, Hee-Woong Lim, Yong Hoon Kim, Wesley Y Ho, Yee Hoon Foong, Victoria L Nelson, Hoang C B Nguyen, Kavya Chegireddy, Jihoon Kim, Andreas Habertheuer, Prashanth Vallabhajosyula, Taku Kambayashi, Kyoung-Jae Won, Mitchell A Lazar
Obesity is characterized by an accumulation of macrophages in adipose, some of which form distinct crown-like structures (CLS) around fat cells. While multiple discrete adipose tissue macrophage (ATM) subsets are thought to exist, their respective effects on adipose tissue, and the transcriptional mechanisms that underlie the functional differences between ATM subsets, are not well understood. We report that obese fat tissue of mice and humans contain multiple distinct populations of ATMs with unique tissue distributions, transcriptomes, chromatin landscapes, and functions...
May 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29750646/circulating-steroid-levels-as-correlates-of-adipose-tissue-phenotype-in-premenopausal-women
#6
Geneviève B Marchand, Anne-Marie Carreau, Sofia Laforest, Julie-Anne Côté, Marleen Daris, Katherine Cianflone, Cornelia Prehn, Jerzy Adamski, André Tchernof
Background Obesity-related alterations in the circulating steroid hormone profile remain equivocal in women. Our objective was to identify circulating steroid levels that relate to increased adiposity and altered adipose phenotype in premenopausal women. Materials and methods In a sample of 42 premenopausal women [age 46 ± 3 years; body mass index (BMI) 27.1 ± 4.2 kg/m2], 19 plasma steroids were quantified by electrospray ionization-liquid chromatography-tandem mass spectroscopy (ESI-LC-MS/MS). Body composition and fat distribution were assessed by dual-energy X-ray absorptiometry (DXA) and computed tomography (CT), respectively...
May 11, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29743341/involvement-of-adipose-tissue-inflammation-and-dysfunction-in-virus-induced-type-1-diabetes
#7
James C Needell, Madalyn Brown, Danny Zipris
The etiopathogenesis of type 1 diabetes (T1D) remains poorly understood. We used the LEW1.WR1 rat model of Kilham rat virus (KRV)-induced T1D to better understand the role of the innate immune system in the mechanism of virus-induced disease. We observed that infection with KRV results in cell influx into visceral adipose tissue soon following infection prior to insulitis and hyperglycemia. In sharp contrast, subcutaneous adipose tissue is free of cellular infiltration, whereas β-cell inflammation and diabetes are observed beginning on day 14 post-infection...
May 9, 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29743167/characterising-the-adipose-inflammatory-microenvironment-in-male-breast-cancer
#8
Tom Lees, Angharad Cullinane, Alexandra Condon, Abeer M Shaaban, Matthew Humphries, Valerie Speirs
Male breast cancer (MBC) incidence seems to parallel global increases in obesity. The stromal microenvironment contributes to carcinogenesis, yet the role of adipocytes in this is understudied in MBC. We identified 4 cohorts of male breast tissues diagnosed when obesity was rare (archival cohort) and more common (contemporary cohort). We examined the microenvironment of archival and contemporary cohorts of MBC, diagnosed 1940 - 1970 and 1998 - 2006, respectively, with 2 cohorts of, archival and contemporary gynaecomastia, diagnosed 1940 - 1979 and 1996 - 2011, respectively serving as controls...
May 9, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29740101/tissue-distribution-and-cell-tropism-of-brucella-canis-in-naturally-infected-canine-foetuses-and-neonates
#9
Tayse Domingues de Souza, Tatiane Furtado de Carvalho, Juliana Pinto da Silva Mol, João Vítor Menezes Lopes, Monique Ferreira Silva, Tatiane Alves da Paixão, Renato Lima Santos
Brucella canis infection is an underdiagnosed zoonotic disease. Knowledge about perinatal brucellosis in dogs is extremely limited, although foetuses and neonates are under risk of infection due to vertical transmission. In this study, immunohistochemistry was used to determine tissue distribution and cell tropism of B. canis in canine foetuses and neonates. Diagnosis of B. canis in tissues of naturally infected pups was based on PCR and sequencing of amplicons, bacterial isolation, and immunohistochemistry, whose specificity was confirmed by laser capture microdissection...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29738484/human-macrophages-preferentially-infiltrate-the-superficial-adipose-tissue
#10
Giuseppe Cappellano, Evi M Morandi, Johannes Rainer, Philipp Grubwieser, Katharina Heinz, Dolores Wolfram, David Bernhard, Susanne Lobenwein, Gerhard Pierer, Christian Ploner
Human abdominal subcutaneous adipose tissue consists of two individual layers—the superficial adipose tissue (SAT) and deep adipose tissue (DAT)—separated by the Scarpa’s fascia. The present study focuses on the analysis of morphological and immunological differences of primary adipocytes, adipose-derived stem cells (ASC), and tissue-infiltrating immune cells found in SAT and DAT. Adipocytes and stromal vascular fraction (SVF) cells were isolated from human SAT and DAT specimens and phenotypically characterized by in vitro assays...
May 8, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29736674/modulation-of-vascular-reactivity-by-perivascular-adipose-tissue-pvat
#11
REVIEW
Claudia Agabiti-Rosei, Anna Paini, Carolina De Ciuceis, Sarah Withers, Adam Greenstein, Anthony M Heagerty, Damiano Rizzoni
PURPOSE OF REVIEW: In this review, we discuss the role of perivascular adipose tissue (PVAT) in the modulation of vascular contractility and arterial pressure, focusing on the role of the renin-angiotensin-aldosterone system and oxidative stress/inflammation. RECENT FINDINGS: PVAT possesses a relevant endocrine-paracrine activity, which may be altered in several pathophysiological and clinical conditions. During the last two decades, it has been shown that PVAT may modulate vascular reactivity...
May 7, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29735414/adipocyte-derived-lysophosphatidylcholine-activates-adipocyte-and-adipose-tissue-macrophage-nod-like-receptor-protein-3-inflammasomes-mediating-homocysteine-induced-insulin-resistance
#12
Song-Yang Zhang, Yong-Qiang Dong, Pengcheng Wang, Xingzhong Zhang, Yu Yan, Lulu Sun, Bo Liu, Dafang Zhang, Heng Zhang, Huiying Liu, Wei Kong, Gang Hu, Yatrik M Shah, Frank J Gonzalez, Xian Wang, Changtao Jiang
The adipose Nod-like receptor protein 3 (NLRP3) inflammasome senses danger-associated molecular patterns (DAMPs) and initiates insulin resistance, but the mechanisms of adipose inflammasome activation remains elusive. In this study, Homocysteine (Hcy) is revealed to be a DAMP that activates adipocyte NLRP3 inflammasomes, participating in insulin resistance. Hcy-induced activation of NLRP3 inflammasomes were observed in both adipocytes and adipose tissue macrophages (ATMs) and mediated insulin resistance. Lysophosphatidylcholine (lyso-PC) acted as a second signal activator, mediating Hcy-induced adipocyte NLRP3 inflammasome activation...
April 27, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29733540/fabp4-suppresses-proliferation-and-invasion-of-hepatocellular-carcinoma-cells-and-predicts-a-poor-prognosis-for-hepatocellular-carcinoma
#13
Cheng-Qian Zhong, Xiu-Ping Zhang, Ning Ma, Er-Bin Zhang, Jing-Jing Li, Ya-Bo Jiang, Yu-Zhen Gao, Yan-Mei Yuan, Shi-Qian Lan, Dong Xie, Shu-Qun Cheng
Adipocyte fatty acid-binding protein (FABP4) is abundant in macrophage and adipocyte. It is known to be involved in lipid metabolism. The role of FABP4 has been reported in various cancers, such as non-small cell lung cancer, breast cancer, ovarian cancer, and prostatic cancer. However, its role remains unclear in hepatocellular carcinoma (HCC). In our study, we investigated the expression of FABP4 at both mRNA and protein levels, and by examining 175 cases of patients with cancer of the liver tissue microarray, the significance between the expression of FABP4 and clinical characteristics had been discussed...
May 7, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29730778/expression-of-genes-associated-with-inflammation-and-iron-metabolism-in-3t3-l1-cells-induced-with-macrophages-conditioned-medium-glucose-and-iron
#14
L Briones, M Andrews, F Pizarro, M Arredondo-Olguín
Obesity is characterized by a chronic inflammatory process, with an increased volume of total adipose tissue, especially visceral, which secretes pro-inflammatory cytokines such as TNF-α and IL-6. Hepcidin (Hpc), a main iron metabolism regulator, is synthetized by an IL-6 stimuli, among others, in liver and adipose tissue, favoring an association between the inflammatory process and iron metabolism. Still there are questions remain regarding the interaction of these factors. Our aim was to study the effect of a macrophage-conditioned medium (MCM) on adipocyte cells challenged with glucose and/or iron...
May 5, 2018: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/29729271/decreased-serum-estrogen-improves-fat-graft-retention-by-enhancing-early-macrophage-infiltration-and-inducing-adipocyte-hypertrophy
#15
Hsiaopei Mok, Jingwei Feng, Wansheng Hu, Jing Wang, Junrong Cai, Feng Lu
BACKGROUND: Fat grafting is a commonly used procedure; however, the mechanisms that regulate graft outcomes are not clear. Estrogen has been associated with vascularization, inflammation and fat metabolism, yet its role in fat grafting is unclear. METHODS: Mice were implanted with 17β-estradiol pellets (high estrogen, HE), underwent ovariectomy (low estrogen level, OVX) or sham surgery (normal estrogen level, CON). 45 days later, inguinal fat of mice was autografted subcutaneously...
May 2, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29721509/anthocyanins-function-as-anti-inflammatory-agents-in-a-drosophila-model-for-adipose-tissue-macrophage-infiltration
#16
Alice Valenza, Carola Bonfanti, Maria Enrica Pasini, Paola Bellosta
Epidemiological and preclinical studies have demonstrated that bioactive foods like flavonoids, polyphenolic compounds derived from fruits and vegetables, exert a protective action against obesity, cardiovascular disorders, and Adipocyte Tissue Macrophage infiltration (ATM). All these pathologies are characterized by increase in reactive oxygen species (ROS) and in proinflammatory cytokines that have been shown to favor the migration of immune cells, particularly of macrophages, in metabolically active organs like the liver and adipose tissue, that in Drosophila are constituted by a unique organ: the fat body...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29698883/a-role-for-tlr10-in-obesity-and-adipose-tissue-morphology
#17
Lily Boutens, Andreea-Manuela Mirea, Inge van den Munckhof, Marije Doppenberg-Oosting, Martin Jaeger, Anneke Hijmans, Mihai G Netea, Leo A B Joosten, Rinke Stienstra
Toll like receptors (TLRs) are expressed in adipose tissue and promote adipose tissue inflammation during obesity. Recently, anti-inflammatory properties have been attributed to TLR10 in myeloid cells, the only member of the TLR family with inhibitory activity. In order to assess whether TLR10-induced inhibition of inflammation may be protective during the development of obesity and metabolic abnormalities we used transgenic human TLR10 mice (hTLR10tg) and wild type (WT) controls on a C57B6J background. HFD-feeding enhanced TLR10 expression in the adipose tissue, and HFD-fed hTLR10tg mice displayed reduced adipocyte size, adipose tissue weight, and a trend toward lower plasma insulin levels compared to WT mice...
April 23, 2018: Cytokine
https://www.readbyqxmd.com/read/29669585/endoplasmic-reticulum-stress-in-perivascular-adipose-tissue-promotes-destabilization-of-atherosclerotic-plaque-by-regulating-gm-csf-paracrine
#18
Ru Ying, Sheng-Wei Li, Jia-Yuan Chen, Hai-Feng Zhang, Ying Yang, Zhen-Jie Gu, Yang-Xin Chen, Jing-Feng Wang
BACKGROUND: Perivascular adipose tissue (PVAT) accelerates plaque progression and increases cardiovascular risk. We tested the hypothesis that PVAT contributed to plaque vulnerability and investigated whether endoplasmic reticulum stress (ER stress) in PVAT played an important role in vulnerable plaque. METHODS: We transplanted thoracic aortic PVAT or subcutaneous adipose tissue as a control, from donor mice to carotid arteries of recipient apolipoprotein E deficient (apoE-/- ) mice after removing carotid artery collar placed for 6 weeks...
April 18, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29668871/transgenic-mice-overexpressing-srebp-1a-in-male-ob-ob-mice-exhibit-lipodystrophy-and-exacerbate-insulin-resistance
#19
Hiroshi Ohno, Takashi Matsuzaka, Nie Tang, Rahul Sharma, Kaori Motomura, Takuya Shimura, Aoi Satoh, Song-Iee Han, Yoshinori Takeuchi, Yuichi Aita, Hitoshi Iwasaki, Shigeru Yatoh, Hiroaki Suzuki, Motohiro Sekiya, Yoshimi Nakagawa, Hirohito Sone, Naoya Yahagi, Nobuhiro Yamada, Yoshikazu Higami, Hitoshi Shimano
Sterol regulatory element-binding protein-1a (SREBP-1a) is a key transcription factor which activates the expression of genes involved in the synthesis of fatty acids, triglycerides, and cholesterol. Transgenic mice that overexpress the nuclear form of SREBP-1a under the control of phosphoenolpyruvate carboxykinase (PEPCK) promoter (Tg-1a) were previously shown to display a lipodystrophic phenotype characterized by enlarged and fatty livers, diminished peripheral white adipose tissue (WAT), and insulin resistance...
April 12, 2018: Endocrinology
https://www.readbyqxmd.com/read/29663892/complement-components-c3-and-c4-and-the-metabolic-syndrome
#20
Melanie Copenhaver, Chack-Yung Yu, Robert P Hoffman
INTRODUCTION: Increased systemic inflammation is engaged likely plays a significant role in the development of adult cardiometabolic diseases such as insulin resistance, dyslipidemia, atherosclerosis, and hypertension. The complement system is part of the innate immune system and plays a key role in in regulation inflammation. Of particular importance is the activation of complement components C3 and C4. C3 is produced primarily by the liver but is also produced in adipocytes, macrophages and endothelial cells, all of which are present in adipose tissue...
April 17, 2018: Current Diabetes Reviews
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