Chang Hee Kim, Hae-Seong Nam, Eun Hee Lee, Seung Hun Han, Hyun Jung Cho, Hee Jin Chung, Nam Soo Lee, Suk Jin Choi, Hojoong Kim, Jeong Seon Ryu, Junhye Kwon, Hongtae Kim
NLBP (novel LZAP-binding protein) was recently shown to function as a tumor suppressor capable of inhibiting the NFκB signaling pathway. NLBP is also known as a negative regulator of cell invasion, and its expression is reduced in several cancer cell lines that have little invasive activity. Although these phenomena suggest that NLBP may be a potential tumor suppressor, its role as a tumor suppressor in human lung cancer is not well established. In contrast to our expectation, NLBP was highly expressed in the early stage of lung adenocarcinoma tissues, and overexpression of NLBP promoted proliferation of H1299 lung adenocarcinoma cells...
August 1, 2013: Cell Cycle