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Exercise is medicine

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https://www.readbyqxmd.com/read/28916931/physical-exercise-prescription-in-metabolic-chronic-disease
#1
Laura Stefani, Giorgio Galanti
Metabolic syndrome as a consequence of the association to overweight, hypertension, and diabetes is at high risk of coronary events. Regular physical training has been recently promoted to reduce cardiovascular risks factors, by the improved lifestyle and also by the "anti-inflammatory effectiveness." A positive impact has been shown in case of cancer survived patients either with or without comorbidities and especially in those subjects where the inflammatory process is globally represented. The American College of Sports Medicine (ACSM) guidelines and more recently a new Italian model both support the role of "exercise as therapy" at moderate level of energy expenditure...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28911611/antifatigue-and-increasing-exercise-performance-of-actinidia-arguta-crude-alkaloids-in-mice
#2
Yangyang Liu, Changjiang Liu
Actinidia arguta (Siebold et Zucc.) Planch. ex. Miq. is one of the most recently domesticated fruit species with increasing commercial production worldwide. It is a well-known traditional Chinese medicine and is used to reduce blood glucose and treat atopic dermatitis. In addition, it possesses antioxidant, anticancer, and antiallergic properties. In this study, we investigated the physical antifatigue and exercise performance effects of A. arguta crude alkaloids (AACA) extracted with 70% ethanol. Four groups of male Kunming mice (n = 16) were orally administered AACA at doses of 0 mg/kg/d (vehicle), 50 mg/kg/d (AACA-50), 100 mg/kg/d (AACA-100), or 200 mg/kg/d (AACA-200) for 28 days...
October 2016: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28903545/the-road-from-development-to-approval-evaluating-the-body-of-evidence-to-confirm-biosimilarity
#3
Paul Declerck, Mourad Farouk Rezk
Biosimilars are products that contain a similar version of the active substance of an already authorized original biologic medicinal product (reference medicinal product). Their development requires special consideration, as similarity to the reference agent needs to be established through a comprehensive comparability exercise. Given the complex nature of these agents, minor structural differences may emerge, but the process of biosimilarity determination is designed to ascertain that the nature and impact of these differences are not clinically significant...
August 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28903544/the-process-defines-the-product-what-really-matters-in-biosimilar-design-and-production
#4
Arnold G Vulto, Orlando A Jaquez
Biologic drugs are highly complex molecules produced by living cells through a multistep manufacturing process. The key characteristics of these molecules, known as critical quality attributes (CQAs), can vary based on post-translational modifications that occur in the cellular environment or during the manufacturing process. The extent of the variation in each of the CQAs must be characterized for the originator molecule and systematically matched as closely as possible by the biosimilar developer to ensure bio-similarity...
August 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28903543/biosimilars-in-rheumatology-a-review-of-the-evidence-and-their-place-in-the-treatment-algorithm
#5
Hendrik Schulze-Koops, Alla Skapenko
Determining biosimilarity involves a comprehensive exercise with a focus on determining the comparability of the molecular characteristics and preclinical profile of the biosimilar and reference product, such that there is less need for extensive clinical testing to assure comparability of clinical outcomes. Three anti-TNF biosimilar agents are approved for patients with rheumatic diseases in the European Union. The infliximab (Remicade®) biosimilars CT-P13 (Remsima® and Inflectra®) and SB2 (Flixabi®) and the etanercept (Enbrel®) biosimilar SB4 (Benepali®) have shown close comparability to their reference medicinal products, having undergone extensive evaluations...
August 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28899714/qualitative-evaluation-of-a-narrative-reflection-program-to-help-medical-trainees-recognize-and-avoid-overuse-am-i-doing-what-s-right-for-the-patient
#6
Tanner Caverly, Daniel Matlock, Jocelyn Thompson, Brandon Combs
OBJECTIVE: The Do No Harm Project is a novel reflective writing program that encourages medical trainees to reflect on and write up clinical narratives about instances of avoidable medical overuse. Our goal is to describe this program and to explore the effect of the program on those participating. METHODS: Semi-structured interviews were conducted to explore how participating in the project influenced the thinking, attitudes, and behaviors of participating internal medicine residents...
September 8, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28895673/the-effect-of-interferential-current-therapy-on-patients-with-subacromial-impingement-syndrome-a-randomized-double-blind-sham-controlled-study
#7
Tuba Nazligul, Pinar Akpinar, Ilknur Aktas, Feyza Unlu Ozkan, Hulya Cagliyan Hartevioglu
BACKGROUND: Although interferential current (IFC) is a common electrotherapeutic modality used to treat musculoskeletal pain, there is not any randomized controlled trial investigating its clinical efficacy in subacromial impingement syndrome (SAIS). AIM: Investigation of effectiveness of IFC treatment in patients with SAIS. DESIGN: Randomized, double-blind, sham-controlled study. SETTING: Physical medicine and rehabilitation outpatient clinic...
September 11, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28891448/a-special-focus-on-selexipag-treatment-of-pulmonary-arterial-hypertension
#8
Louise Marqvard Sørensen, Markus Wehland, Marcus Krüger, Ulf Simonsen, Mohamed Zakaria Nassef, Manfred Infanger, Daniela Grimm
BACKGROUND: This review focuses on the treatment of pulmonary arterial hypertension (PAH) with selexipag and compares its drug-related therapeutic effects with those of prostacyclin analogues. METHODS: We searched the relevant literature and summarized the current clinical trials concerning selexipag and PAH. RESULTS: With only few cases per million, PAH is a rare disease, but when untreated it can be life threatening. PAH is linked to elevated levels of endothelin (ET-1) and decreased levels of nitric oxide (NO) and prostacyclin (PGI2)...
September 7, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28890833/gender-success-and-drop-out-during-a-resistance-exercise-program-in-community-dwelling-old-adults
#9
O G Geirsdottir, M Chang, K Briem, P V Jonsson, I Thorsdottir, A Ramel
BACKGROUND: Resistance exercise training can be effective against sarcopenia. We identified predictors of drop-out and compared physical outcomes between men and women after such training. METHODS: Subjects (N = 236, 73.7 ± 5.7 years) participated in a 12-week resistance exercise program. Outcome variables were measured at baseline and endpoint. RESULTS: Drop-out was 11.9% and not significantly different between genders. Drop-outs were significantly older and had poorer strength and physical function in comparison to completers...
2017: Journal of Aging Research
https://www.readbyqxmd.com/read/28887241/non-invasive-peripheral-artery-disease-screening-tools-a-deficient-knowledge-among-french-vascular-residents-from-four-medical-schools
#10
O Stivalet, L Omarjee, S Chaudru, C Hoffmann, L Bressollette, K P Cohoon, V Jaquinandi, G Mahe
BACKGROUND: Ankle-brachial index (ABI) at rest, Post-exercise ABI and Toe-Brachial Index (TBI) are essential diagnostic tools recommended for peripheral artery disease (PAD) diagnosis. Our study investigates the level of knowledge on these three tests among vascular medicine residents from four French medical schools in France. PATIENTS AND METHODS: We included nineteen vascular medicine residents in a cross-sectional study. During an annual obligatory seminar, all residents accepted to fill three questionnaires concerning knowledge about these three tests...
September 5, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28886820/gastrointestinal-conditions-in-the-female-athlete
#11
REVIEW
Barry Kent Diduch
Exercise can have significant effects on gastrointestinal diseases. Regular, moderate exercise can impart beneficial effects for the intestinal microbiome, irritable bowel syndrome symptoms, and inflammatory bowel disease. High-intensity training or prolonged endurance training, on the other hand, can have negative effects on these same entities. Female athletes report a higher prevalence of irritable bowel syndrome and celiac disease, and furthermore, have gastrointestinal symptoms modulated by the menstrual cycle...
October 2017: Clinics in Sports Medicine
https://www.readbyqxmd.com/read/28880460/cryopreserved-off-the-shelf-allogeneic-adipose-derived-stromal-cells-for-therapy-in-patients-with-ischemic-heart-disease-and-heart-failure-a-safety-study
#12
Jens Kastrup, Mandana Haack-Sørensen, Morten Juhl, Rebekka Harary Søndergaard, Bjarke Follin, Lisbeth Drozd Lund, Ellen Mønsted Johansen, Abbas Ali Qayyum, Anders Bruun Mathiasen, Erik Jørgensen, Steffen Helqvist, Jens Jørgen Elberg, Helle Bruunsgaard, Annette Ekblond
The present first-in-human clinical trial evaluated the safety and feasibility of a newly developed and cryopreserved Cardiology Stem Cell Centre adipose-derived stromal cell (CSCC_ASC) product from healthy donors for intramyocardial injection in ten patients with ischemic heart disease and ischemic heart failure (IHF). Batches of CSCC_ASC were isolated from three healthy donors by liposuction from abdominal adipose tissue. Adipose mesenchymal stromal cells were culture expanded in bioreactors without the use of animal constituents, cryopreserved, and stored in vials in nitrogen dry-storage containers until use...
September 7, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28876990/curriculum-redesign-in-veterinary-medicine-part-i
#13
Kristin P Chaney, Maria L Macik, Jacqueline S Turner, Jodi A Korich, Kenita S Rogers, Debra Fowler, Elizabeth M Scallan, Lisa M Keefe
Curricular review is considered a necessary component for growth and enhancement of academic programs and requires time, energy, creativity, and persistence from both faculty and administration. At Texas A&M College of Veterinary Medicine & Biomedical Sciences (TAMU), the faculty and administration partnered with the university's Center for Teaching Excellence to create a faculty-driven, data-enhanced curricular redesign process. The 8-step process begins with the formation of a dedicated faculty curriculum design team to drive the redesign process and to support the college curriculum committee...
2017: Journal of Veterinary Medical Education
https://www.readbyqxmd.com/read/28876380/portuguese-and-brazilian-guidelines-for-the-treatment-of-depression-exercise-as-medicine
#14
Lara F Carneiro, Maria P Mota, Felipe Schuch, Andrea Deslandes, José Vasconcelos-Raposo
Depression is a psychiatric disorder and major contributor to the burden of disease worldwide. The strength of evidence of the benefits of exercise as a therapeutic intervention for patients with depression has expanded in the last 30 years. In fact, the available evidence indicates exercise can not only help manage depressive symptoms, but also effect significant improvements in other health outcomes. Clinical guidelines including such recommendations have been issued by different agencies, namely the UK National Institute for Health and Clinical Excellence (NICE), the American Psychiatric Association (APA), and the Royal Australian and New Zealand College of Psychiatrists (RANZCP)...
August 30, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28872752/time-on-androgen-deprivation-therapy-and-adaptations-to-exercise-secondary-analysis-from-a-12-month-randomized-controlled-trial-in-men-with-prostate-cancer
#15
Dennis R Taaffe, Laurien M Buffart, Robert U Newton, Nigel Spry, James Denham, David Joseph, David Lamb, Suzanne K Chambers, Daniel A Galvão
OBJECTIVES: To explore if duration of prior exposure to androgen deprivation therapy (ADT) in men with prostate cancer (PCa) undertaking a yearlong exercise program moderates the exercise response on body composition and muscle performance. In addition, we explored the moderator effect of baseline testosterone, time since ADT, and baseline value of the outcome. PATIENTS AND METHODS: In a multicenter randomized controlled trial, 100 patients previously treated for either 6 months (short-term) or 18 months (long-term) ADT in combination with radiotherapy as part of the TROG 03...
September 5, 2017: BJU International
https://www.readbyqxmd.com/read/28869808/pediatric-emergency-in-brazil-the-consolidation-of-an-area-in-the-pediatric-field
#16
REVIEW
Jefferson P Piva, Patrícia M Lago, Pedro Celiny R Garcia
OBJECTIVE: The aim of this study was to present a review on the evolution, development, and consolidation of the pediatric emergency abroad and in Brazil, as well as to discuss the residency program in this key area for pediatricians. DATA SOURCES: This was a narrative review, in which the authors used pre-selected documents utilized as the minimum requirements for the Residency Program in Pediatric Emergency Medicine and articles selected by interest for the theme development, at the SciELO and Medline databases, between 2000 and 2017...
September 1, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28858917/why-do-we-fail-to-deliver-evidence-based-practice-in-critical-care-medicine
#17
Curtis H Weiss
PURPOSE OF REVIEW: The use of evidence-based practices in clinical practice is frequently inadequate. Recent research has uncovered many barriers to the implementation of evidence-based practices in critical care medicine. Using a comprehensive conceptual framework, this review identifies and classifies the barriers to implementation of several major critical care evidence-based practices. RECENT FINDINGS: The many barriers that have been recently identified can be classified into domains of the consolidated framework for implementation research (CFIR)...
October 2017: Current Opinion in Critical Care
https://www.readbyqxmd.com/read/28857391/estimated-peak-functional-capacity-an-accurate-method-for-assessing-change-in-peak-oxygen-consumption-after-cardiac-rehabilitation
#18
S Nichols, D O Gleadall-Siddall, R Antony, A L Clark, J G F Cleland, S Carroll, L Ingle
OBJECTIVE: Cardiopulmonary exercise testing (CPET) is the 'gold standard' method of determining VO2peak . When CPET is unavailable, VO2peak may be estimated from treadmill or cycle ergometer workloads and expressed as estimated metabolic equivalents (METs). Cardiac rehabilitation (CR) programmes use estimated VO2peak (METs) to report changes in cardiorespiratory fitness (CRF). However, the accuracy of determining changes in VO2peak based on estimated functional capacity is not known. METHODS: A total of 27 patients with coronary heart disease (88·9% male; age 59·5 ± 10·0 years, body mass index 29·6 ± 3·8 kg m(-2) ) performed maximal CPET before and after an exercise-based CR intervention...
August 30, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/28851351/community-pharmacists-knowledge-practices-and-beliefs-about-complementary-and-alternative-medicine-in-palestine-a-cross-sectional-study
#19
Naser Y Shraim, Ramzi Shawahna, Muna A Sorady, Banan M Aiesh, Ghadeer Sh Alashqar, Raghad I Jitan, Waed M Abu Hanieh, Yasmeen B Hotari, Waleed M Sweileh, Sa'ed H Zyoud
BACKGROUND: Complementary and alternative medicine (CAM) utilization is dramatically increasing among patients. As community pharmacies are a major provider of CAM products, community pharmacists need to have the sufficient knowledge and information to advice their patients, answer their inquiries and to be proactive in the healthcare process to ensure optimal therapy outputs and minimize both drug-drug and drug-herb interactions. Therefore, the main objective of this study was to assess the knowledge, beliefs, and practices of community pharmacists in Palestine about CAM...
August 29, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28845629/meeting-reports-exercise-is-medicine-israel-5th-annual-conference-endocrine-aspects-tel-aviv-israel-may-10th-2017
#20
Gal Dubnov-Raz, Jürgen M Steinacker, Yonit Marcus, Konstantina Dipla, Dror Dicker, Jay R Hoffman, Ilan Shimon, Yona Greenman, Liana Tripto-Shkolnik, Dania Hirsch, Assaf Buch, Mickey Arieli, Naama W Constantini
No abstract text is available yet for this article.
September 2017: Pediatric Endocrinology Reviews: PER
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