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https://www.readbyqxmd.com/read/29932769/chronic-atorvastatin-and-exercise-can-partially-reverse-established-skeletal-muscle-microvasculopathy-in-metabolic-syndrome
#1
Kent A Lemaster, Stephanie J Frisbee, Luc DuBois, Nikolaos Tzemos, Fan Wu, Matthew T Lewis, Robert W Wiseman, Jefferson C Frisbee
It has been long known that chronic metabolic disease is associated with a parallel increase in the risk for developing peripheral vascular disease. Although more clinically relevant, our understanding about reversing established vasculopathy is limited in comparison to our understanding of the mechanisms and development of impaired vascular structure/function under these conditions. Using the 13-week old obese Zucker rat (OZR) model of the metabolic syndrome, where microvascular dysfunction is sufficiently established to contribute to impaired skeletal muscle function, we imposed a 7-week intervention of chronic atorvastatin (ATOR) treatment, chronic treadmill exercise (EXER), or both...
June 22, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29921306/pdgf-bb-regulates-the-pulmonary-vascular-tone-impact-of-prostaglandins-calcium-mapk-and-pi3k-akt-mtor-signalling-and-actin-polymerisation-in-pulmonary-veins-of-guinea-pigs
#2
Annette D Rieg, Said Suleiman, Carolin Anker, Eva Verjans, Rolf Rossaint, Stefan Uhlig, Christian Martin
BACKGROUND: Platelet-derived growth factor (PDGF)-BB and its receptor PDGFR are highly expressed in pulmonary hypertension (PH) and mediate proliferation. Recently, we showed that PDGF-BB contracts pulmonary veins (PVs) and that this contraction is prevented by inhibition of PDGFR-β (imatinib/SU6668). Here, we studied PDGF-BB-induced contraction and downstream-signalling in isolated perfused lungs (IPL) and precision-cut lung slices (PCLS) of guinea pigs (GPs). METHODS: In IPLs, PDGF-BB was perfused after or without pre-treatment with imatinib (perfused/nebulised), the effects on the pulmonary arterial pressure (PPA ), the left atrial pressure (PLA ) and the capillary pressure (Pcap ) were studied and the precapillary (Rpre ) and postcapillary resistance (Rpost ) were calculated...
June 19, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29899878/prostaglandins-in-the-pathogenesis-of-kidney-diseases
#3
REVIEW
Yuanyuan Li, Weiwei Xia, Fei Zhao, Zhaoying Wen, Aihua Zhang, Songming Huang, Zhanjun Jia, Yue Zhang
Prostaglandins (PGs) are important lipid mediators produced from arachidonic acid via the sequential catalyzation of cyclooxygenases (COXs) and specific prostaglandin synthases. There are five subtypes of PGs, namely PGE2, PGI2, PGD2, PGF2α, and thromboxane A2 (TXA2). PGs exert distinct roles by combining to a diverse family of membrane-spanning G protein-coupled prostanoid receptors. The distribution of these PGs, their specific synthases and receptors vary a lot in the kidney. This review summarized the recent findings of PGs together with the COXs and their specific synthases and receptors in regulating renal function and highlighted the insights into their roles in the pathogenesis of various kidney diseases...
May 29, 2018: Oncotarget
https://www.readbyqxmd.com/read/29849735/serum-metabolomics-study-based-on-lc-ms-and-antihypertensive-effect-of-uncaria-on-spontaneously-hypertensive-rats
#4
Ana Liu, Yan-Jun Chu, Xiaoming Wang, Ruixue Yu, Haiqiang Jiang, Yunlun Li, Honglei Zhou, Li-Li Gong, Wen-Qing Yang, Jianqing Ju
Our previous studies have shown that Uncaria has an important role in lowering blood pressure, but its intervention mechanism has not been clarified completely in the metabolic level. Therefore, in this study, a combination method of HPLC-TOF/MS-based metabolomics and multivariate statistical analyses was employed to explore the mechanism and evaluate the antihypertensive effect of Uncaria . Serum samples were analyzed and identified by HPLC-TOF/MS, while the acquired data was further processed by partial least squares discriminant analysis (PLS-DA) and orthogonal partial least squares discriminant analysis (OPLS-DA) to discover the perturbed metabolites...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29803832/acute-beneficial-effects-of-sodium-nitroprusside-in-a-rabbit-model-of-massive-pulmonary-embolism-associated-with-circulatory-shock
#5
Delong Yu, Yuting Wang, Yijun Yu, Yunqi Zhong, Lihua Huang, Mingjing Zhang, Liqun Hu, Xiaoyan Liu, Ye Gu
We established a rabbit model of acute massive pulmonary embolism with associated circulatory shock using autologous blood clots. Rabbits were randomly divided into sham operation group (S group), model group (M group, equal volume of saline, i.v. after shock), and sodium nitroprusside group (SNP group, sodium nitroprusside, i.v. after shock). SNP treatment significantly decreased mean pulmonary arterial pressure and increased mean arterial pressure and arterial partial pressure of oxygen (PaO2 ) and resulted in a partial reversal of the acute circulatory failure...
May 24, 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29793021/phosphoinositide-3-kinase-p110%C3%AE-negatively-regulates-thrombopoietin-mediated-platelet-activation-and-thrombus-formation
#6
T A Blair, S F Moore, T G Walsh, J L Hutchinson, T N Durrant, K E Anderson, A W Poole, I Hers
Phosphoinositide 3-kinase (PI3K) plays an important role in platelet function and contributes to platelet hyperreactivity induced by elevated levels of circulating peptide hormones, including thrombopoietin (TPO). Previous work established an important role for the PI3K isoform; p110β in platelet function, however the role of p110α is still largely unexplored. Here we sought to investigate the role of p110α in TPO-mediated hyperactivity by using a conditional p110α knockout (KO) murine model in conjunction with platelet functional assays...
May 21, 2018: Cellular Signalling
https://www.readbyqxmd.com/read/29771124/genistein-ameliorates-non-alcoholic-fatty-liver-disease-by-targeting-thromboxane-a2-pathway
#7
Wenzhe Wang, Junliang Chen, Jinyan Mao, Hongling Li, Mingfu Wang, Hao Zhang, Haitao Li, Wei Chen
Non-alcoholic fatty liver disease (NAFLD) is now a public health issue worldwide, but no drug has received approval yet. Genistein, an isoflavonoid derived from soybean, ameliorates high fat diet-induced NAFLD in mice, but the molecular underpinnings remain largely elusive. Arachidonic acid is a major ingredient of animal fats, and arachidonic acid cascade has been implicated in chronic inflammation. In this study, we investigated whether genistein against NAFLD by targeting arachidonic acid cascade. By using a mouse model, we showed that genistein supplementation improved high-fat diet induced NAFLD by normalizing hepatomegaly, liver steatosis, aminotransferase abnormalities and glucose tolerance...
May 17, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29682020/morphometric-analysis-of-dose-dependent-effect-of-progesterone-on-experimental-vasospasm-induced-rat-femoral-arteries
#8
Metin Kasap, Huseyin Canaz, Gokhan Canaz, Mehmet Tokmak, Alper Bingul, Ibrahim Alatas
Objective: Our aim of this study was to determine effective doses of progesterone which has a vasodilatory effect during the early stage of vasospasm. Cerebral vasospasm (CV) is a predominant cause of morbidity and mortality which develops following subarachnoidal hemorrhage (SAH). Etiopathogenesis of CV is multifactorial. Despite many previously performed studies on this issue, the mechanism by which blood and blood products in the subarachnoidal space induce CV has not been clarified yet...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29669967/the-impact-of-night-shift-work-on-platelet-function-in-healthy-medical-staff
#9
Tomoko Nakao, Atsushi Yasumoto, Suzumi Tokuoka, Yoshihiro Kita, Takuya Kawahara, Masao Daimon, Yutaka Yatomi
OBJECTIVES: Rotating shift work has been reported to increase the risk of cardiovascular diseases. Vascular endothelial dysfunction and platelet activation are among the leading causes of thrombus formation in patients with myocardial infarction or stroke. Endothelial function has been shown to be impaired immediately after night-shift work; however, it is not known whether platelets are also activated. The aim of this study was to investigate the acute impact of night-shift work on platelet function...
April 18, 2018: Journal of Occupational Health
https://www.readbyqxmd.com/read/29623931/associations-between-thromboxane-a-synthase-1-gene-polymorphisms-and-the-risk-of-ischemic-stroke-in-a-chinese-han-population
#10
Lei Li, Zhi-Yi He, Yan-Zhe Wang, Xu Liu, Li-Ying Yuan
Thromboxane A synthase 1 (TBXAS1) catalyses the synthesis of thromboxane A2 (TXA2), which plays an important role in the pathogenesis of ischemic stroke. Thus, the TBXAS1 gene was investigated as a candidate gene involved in the formation of atherosclerosis. This case-control study collected peripheral blood specimens and clinical data of 370 ischemic stroke patients and 340 healthy controls in the Northern Chinese Han population from October 2010 to May 2011. Two TBXAS1 single-nucleotide polymorphisms, rs2267682 and rs10487667, were analyzed using a SNaPshot Multiplex sequencing assay to explore the relationships between the single-nucleotide polymorphisms in TBXAS1 and ischemic stroke...
March 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29555597/oxygenation-of-polyunsaturated-fatty-acids-and-oxidative-stress-within-blood-platelets
#11
REVIEW
Michel Lagarde, Michel Guichardant, Nathalie Bernoud-Hubac, Catherine Calzada, Evelyne Véricel
The oxygenation metabolism of arachidonic acid (ArA) has been early described in blood platelets, in particular with its conversion into the potent labile thromboxane A2 that induces platelet aggregation and vascular smooth muscle cells contraction. In addition, the primary prostaglandins D2 and E2 have been mainly reported as inhibitors of platelet function. The platelet 12-lipoxygenase (12-LOX) product, i.e. the hydroperoxide 12-HpETE, appears to stimulate platelet ArA metabolism at the level of its release from membrane phospholipids through phospholipase A2 (cPLA2 ) and cyclooxygenase (COX-1) activities, the first enzymes in prostanoid production cascade...
June 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29512148/eicosanoids-in-platelets-and-the-effect-of-their-modulation-by-aspirin-in-the-cardiovascular-system-and-beyond
#12
REVIEW
Marilena Crescente, Laura Menke, Melissa V Chan, Paul C Armstrong, Timothy D Warner
Platelets are important players in thrombosis and haemostasis with their function being modulated by mediators in the blood and the vascular wall. Among these, eicosanoids can both stimulate and inhibit platelet reactivity. Platelet Cyclooxygenase (COX)-1-generated Thromboxane (TX)A2 is the primary prostanoid that stimulates platelet aggregation; its action is counter-balanced by prostacyclin, a product of vascular COX. Prostaglandin (PG)D2 , PGE2 and 12-hydroxyeicosatraenoic acid (HETE), or 15-HETE, are other prostanoid modulators of platelet activity, but some also play a role in carcinogenesis...
March 7, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29509372/lipid-derivatives-of-arachidonic-acid-used-as-markers-of-atherosclerotic-plaque-instability-a-pilot-study
#13
Aleksander Falkowski, Iwona Gorący, Mariusz Kaczmarczyk, Marcin Szemitko, Hubert Bogacki, Julia Kostka
BACKGROUND: To compare the results of computer estimation of atherosclerotic plaque with biochemical data and ascertain any relationship with the occurrence of stroke. METHODS: The study involved 20 atherosclerotic plaques causing 70-99% stenosis of internal carotid arteries (ICA). Ultrasonographic examination (USG) images of plaques were analyzed using a computer program. A histogram was obtained for each plaque and a gray scale median (GSM) was determined for each histogram in order to measure the echogenicity of an examined plaque...
March 6, 2018: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/29509264/efficacy-of-inhalational-sevoflurane-anesthesia-induction-on-inhibiting-the-stress-response-to-endotracheal-intubation-in-children-with-congenital-heart-disease
#14
C-H Wang, J Luo, J Li, J-Z Zhang, S-Y Huang, W Shao, H-S Ma
OBJECTIVE: To investigate the efficacy of inhalational sevoflurane anesthesia induction on inhibiting the stress response to endotracheal intubation in pediatric patients with congenital heart disease (CHD). PATIENTS AND METHODS: Forty ASA physical status I/II pediatric patients scheduled for interventricular septal defect repair or interatrial septal defect repair, were randomly divided into two groups (20 each): intravenous induction group (Group C) and inhalational sevoflurane anesthesia induction group (Group D)...
February 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29483877/participation-of-arachidonic-acid-metabolism-in-the-aortic-aneurysm-formation-in-patients-with-marfan-syndrome
#15
María E Soto, Verónica Guarner-Lans, Karla Y Herrera-Morales, Israel Pérez-Torres
Marfan syndrome (MFS) is a pleiotropic genetic disease involving the cardiovascular system where a fibrillin-1 mutation is present. This mutation is associated with accelerated activation of transforming growth factor β (TGFβ1) which contributes to the formation of aneurysms in the root of the aorta. There is an imbalance in the synthesis of thromboxane A2 (TXA2 ) and prostacyclin, that is a consequence of a differential protein expression of the isoforms of cyclooxygenases (COXs), suggesting an alteration of arachidonic acid (AA) metabolism...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29477033/involvement-of-thromboxane-a-2-in-interleukin-31-induced-itch-associated-response-in-mice
#16
Tsugunobu Andoh, Sikai Li, Daisuke Uta
BACKGROUND: Atopic dermatitis is a chronic and severe pruritic skin disease. Interlukin-31 (IL-31) has been recently demonstrated to be one of the key pruritogens in atopic dermatitis. However, the mechanisms underlying IL-31-induced itching remains unclear. In our previous study, we have shown that thromboxane (TX) A2 is involved in itch-associated responses in mice with atopy-like skin diseases. METHODS: IL-31 was given intradermally into the rostral back of ICR mice and the hind-paw scratching to the injection site were counted...
April 2018: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29425800/influence-of-the-selective-cox-2-inhibitor-celecoxib-on-sex-differences-in-blood-pressure-and-albuminuria-in-spontaneously-hypertensive-rats
#17
Ahmed A Elmarakby, Mohamed Katary, Jennifer S Pollock, Jennifer C Sullivan
We previously reported that female spontaneously hypertensive rats (SHR) have greater cyclooxygenase-2 (COX-2) expression in the renal medulla and enhanced urinary excretion of prostaglandin (PG) E2 (PGE2 ) metabolites compared to male SHR. Based on the role of COX-2-derived prostanoids in the regulation of cardiovascular health, the aim of the current study was to test the hypothesis that blood pressure (BP) in female SHR is more sensitive to COX-2 inhibition than in males. Seven week old male and female SHR were implanted with telemetry transmitters for continuous BP recording...
March 2018: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/29412230/protective-effect-of-dexmedetomidine-against-myocardial-ischemia-reperfusion-injury-in-rabbits
#18
Jianjun Ren, Changfa Li, Yan Liu, Haitao Liu, Zhenming Dong
PURPOSE: To investigate the influence of dexmedetomidine on myocardial ischemia-reperfusion injury (IRI) in rabbits. METHODS: Twenty-four New Zealand white rabbits were randomly divided into two equal-sized groups: IRI group (group IR) and dexmedetomidine group (group D). Systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP), left ventricular diastolic pressure (LVDP), +dp/dtmax, -dp/dtmax, and t-dp/dtmax were recorded and calculated at the following time points: before (T0) and after (T1) dexmedetomidine infusion, after 30-min ischemia (T2), and after 120-min reperfusion (T3)...
January 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29399191/effects-of-flurbiprofen-on-serum-level-of-interleukin-6-prostacyclin-and-corticosteroid-a2-in-patients-with-bone-metastases-of-cancer
#19
Yanwei Yin, Yusheng Yi, Junmin Yu, Xiuming Sun, Chuansheng Liu, Fenghe Xu
The present study aimed to investigate the effects of flurbiprofen on serum level of interleukin-6 (IL-6), prostacyclin (PGI2) and corticosteroid A2 (TXA2) in patients with bone metastases of cancer. A total of 210 patients with bone metastasis of cancer were randomly divided into two groups: Flurbiprofen axetil analgesia group (group A) and dezocine analgesia group (group B), 105 cases in each group. The analgesic effect was evaluated using visual analogue scale (VAS) scoring system at 1, 12, 24 and 48 h after treatment...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29378362/inhibitory-effects-of-an-orally-active-thromboxane-a2-receptor-antagonist-nstpbp5185-on-atherosclerosis-in-apoe-deficient-mice
#20
Shiu-Wen Huang, Jin-Cherng Lien, Sheng-Chu Kuo, Tur-Fu Huang
Thromboxane A2 (TXA2 ) activation of TP receptor has been shown contributing to the progression and acute complications of atherosclerosis including endothelial dysfunction, platelet hyperactivity and inflammation. Growing evidence suggests that TP receptor may represent as a therapeutic target in atherosclerosis and related cardiovascular diseases. We investigated whether nstpbp5185, an orally active TP receptor antagonist, exhibits protective effects against atherosclerotic progression. Nstpbp5185 and aspirin were orally administered daily for 12 weeks in high-cholesterol-fed ApoE-deficient mice to examine their anti-atherosclerosis effects...
February 2018: Thrombosis and Haemostasis
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