Zhixiang Zhu, Yanggan Luo, Hanjing Liao, Ran Guo, Doudou Hao, Zihan Lu, Manjing Huang, Chenghong Sun, Jingchun Yao, Ning Wei, Kewu Zeng, Pengfei Tu, Guiming Zhang
BACKGROUND: Vascular injury results in uncontrollable hemorrhage in hemorrhagic diseases and excessive antithrombotic therapy. Safe and efficient hemostatic agents which can be orally administered, are urgently needed. Platelets play indispensable roles in hemostasis, but there is no drug exerting hemostatic effects through enhancing platelet function. METHODS: The regulatory effects of icaritin, a natural compound isolated from Herba Epimedii, on the dense granule release, thromboxane A2 (TxA2) synthesis, α-granule release, activation of integrin αIIbβ3, and aggregation of platelets induced by multiple agonists were investigated...
January 15, 2024: Thrombosis and Haemostasis