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https://www.readbyqxmd.com/read/28443168/an-iranian-version-of-the-fukushima-lumbar-spinal-stenosis-scale-fls-25-a-validation-study
#1
Parisa Azimi, Ali Montazeri
STUDY DESIGN: Cross-sectional study. PURPOSE: To translate and validate the Fukushima lumbar spinal stenosis (LSS) scale 25 (FLS-25) for use in Iran. OVERVIEW OF LITERATURE: Tools measuring patient-reported outcomes should satisfy certain psychometric properties. METHODS: FLS-25 is a self-administered scale for evaluating symptoms of LSS. A forward-backward procedure was applied to translate the questionnaire from English into Persian...
April 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/28428266/kca1-1-channels-regulate-%C3%AE-1-integrin-function-and-cell-adhesion-in-rheumatoid-arthritis-fibroblast-like-synoviocytes
#2
Mark R Tanner, Michael W Pennington, Teresina Laragione, Pércio S Gulko, Christine Beeton
Large-conductance calcium-activated potassium channel (KCa1.1; BK, Slo1, MaxiK, KCNMA1) is the predominant potassium channel expressed at the plasma membrane of fibroblast-like synoviocytes isolated from the synovium of patients with rheumatoid arthritis (RA-FLS). It is a critical regulator of RA-FLS migration and invasion and therefore represents an attractive target for the therapy of RA. However, the molecular mechanisms by which KCa1.1 regulates RA-FLS invasiveness have remained largely unknown. Here, we demonstrate that KCa1...
April 20, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28426444/fracture-liaison-services
#3
Karine Briot
PURPOSE OF REVIEW: The purpose of this review is to report the evidence of beneficial effects of Fracture Liaison Service (FLS) including data regarding their impact on subsequent fracture, mortality risk and cost-effectiveness. This review also discusses the limitations of these data and the challenges faced during the implementation of FLS. RECENT FINDINGS: Recent studies showed the beneficial impact of implementation of FLS on the prevention of subsequent fracture risk, reduced mortality and cost-effectiveness...
April 19, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28413632/is-in-vivo-laparoscopic-simulation-learning-a-step-forward-in-the-undergraduate-surgical-education
#4
Panteleimon Pantelidis, Michail Sideris, Georgios Tsoulfas, Efstratia-Maria Georgopoulou, Ismini Tsagkaraki, Nikolaos Staikoglou, Georgios Stagias, Nikolaos Psychalakis, Parmenion Tsitsopoulos, Thanos Athanasiou, Georgios Zografos, Apostolos Papalois
BACKGROUND: Essentials Skills in the Management of Surgical Cases - ESMSC is an International Combined Applied Surgical Science and Wet Lab course addressed at the Undergraduate level. Laparoscopic Skills is a fundamental element of Surgical Education and various Simulation-Based Learning (SBL) models have been endorsed. This study aims to explore if there is any significant difference in delegates' performance depending on whether they completed In Vivo module prior to the equivalent in the laparoscopic simulator...
April 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28411340/attainment-and-retention-of-force-moderation-following-laparoscopic-resection-training-with-visual-force-feedback
#5
Rafael Hernandez, Arzu Onar-Thomas, Francesco Travascio, Shihab Asfour
BACKGROUND: Laparoscopic training with visual force feedback can lead to immediate improvements in force moderation. However, the long-term retention of this kind of learning and its potential decay are yet unclear. METHODS: A laparoscopic resection task and force sensing apparatus were designed to assess the benefits of visual force feedback training. Twenty-two male university students with no previous experience in laparoscopy underwent relevant FLS proficiency training...
April 14, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28410619/foxo1-pxk-pycard-and-samd9l-are-differentially-expressed-by-fibroblast-like-cells-in-equine-synovial-membrane-compared-to-joint-capsule
#6
Line Nymann Thomsen, Preben Dybdahl Thomsen, Alison Downing, Richard Talbot, Lise Charlotte Berg
BACKGROUND: The synovial membrane lines the luminal side of the joint capsule in synovial joints. It maintains joint homeostasis and plays a crucial role in equine joint pathology. When trauma or inflammation is induced in a joint, the synovial membrane influences progression of joint damage. Equine synovial membrane research is hampered by a lack of markers of fibroblast-like synoviocytes (FLS) to distinguish FLS from other fibroblast-like cells in musculoskeletal connective tissues...
April 14, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28408914/transcriptome-analysis-reveals-candidate-genes-related-to-color-fading-of-red-bartlett-pyrus-communis-l
#7
Zhigang Wang, Hong Du, Rui Zhai, Linyan Song, Fengwang Ma, Lingfei Xu
The red color of fruit is an attractive plant trait for consumers. Plants with color-faded fruit have a lower commercial value, such as 'Red Bartlett' pears (Pyrus communis L.) that have dark-red fruit in the early stages of fruit development that subsequently fade to red-green at maturity. To identify the reason for color fading, we first analyzed the anthocyanin content of peel from 'Red Bartlett,' which displays the color fading phenomenon, and 'Starkrimson,' which has no color fading. Results showed that the anthocyanin content of 'Red Bartlett' peel decreased significantly late in fruit development, while in 'Starkrimson' there was no significant decrease...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28401267/paeonol-protects-against-tnf-%C3%AE-induced-proliferation-and-cytokine-release-of-rheumatoid-arthritis-fibroblast-like-synoviocytes-by-upregulating-foxo3-through-inhibition-of-mir-155-expression
#8
Ning Liu, Xue Feng, Wenbo Wang, Xingkai Zhao, Xia Li
BACKGROUND: Fibroblast-like synoviocytes (FLS) play an essential role in the pathogenesis of chronic inflammatory diseases, such as rheumatoid arthritis. Paeonol (Pae) is a phenolic compound found in many traditional Chinese medicine remedies. However, the effects of Pae on TNF-α-stimulated FLS and the underlying molecular mechanism are unknown. In this study, we aimed to investigate the anti-proliferative and anti-inflammatory effect of Pae against activated FLS. MATERIALS AND METHODS: Rheumatoid arthritis FLS (RA-FLS) were pre-treated with different doses (25, 50, and 100 µM) of Pae or miR-155 inhibitor for 30 min or transfected with miR-155 mimic, and then treated with 50 ng/mL of tumor necrosis factor alpha (TNF-α) for 1 h...
April 11, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28399896/glutaminase-1-plays-a-key-role-in-the-cell-growth-of-fibroblast-like-synoviocytes-in-rheumatoid-arthritis
#9
Soshi Takahashi, Jun Saegusa, Sho Sendo, Takaichi Okano, Kengo Akashi, Yasuhiro Irino, Akio Morinobu
BACKGROUND: The recent findings of cancer-specific metabolic changes, including increased glucose and glutamine consumption, have provided new therapeutic targets for consideration. Fibroblast-like synoviocytes (FLS) from rheumatoid arthritis (RA) patients exhibit several tumor cell-like characteristics; however, the role of glucose and glutamine metabolism in the aberrant proliferation of these cells is unclear. Here, we evaluated the role of these metabolic pathways in RA-FLS proliferation and in autoimmune arthritis in SKG mice...
April 11, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28389970/osteoporosis-a-discussion-on-the-past-5%C3%A2-years
#10
REVIEW
Kyle M Schweser, Brett D Crist
PURPOSE OF THE REVIEW: The purposes of this study are to examine the literature within the past 5 years regarding osteoporosis and offer a discussion on new topics and controversies. RECENT FINDINGS: Patient compliance with therapy remains an issue. The effectiveness of Vitamin D and calcium are being called into question Atypical femur fractures have been associated with bisphosphonate and denosumab use. Treatment is both surgical and pharmaceutical. A multidisciplinary approach to osteoporotic fractures is important and having some form of fracture liaison service (FLS) improves the efficacy of osteoporotic care and decreases secondary fractures...
April 7, 2017: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/28386531/draft-genome-sequence-of-cercospora-sojina-isolate-s9-a-fungus-causing-frogeye-leaf-spot-fls-disease-of-soybean
#11
Fanchang Zeng, Chaofan Wang, Guirong Zhang, Junmei Wei, Carl A Bradley, Ray Ming
Fungi are the causal agents of many of the world's most serious plant diseases causing disastrous consequences for large-scale agricultural production. Pathogenicity genomic basis is complex in fungi as multicellular eukaryotic pathogens. The fungus Cercospora sojina is a plant pathogen that threatens global soybean supplies. Here, we report the genome sequence of C. sojina strain S9 and detect genome features and predicted genomic elements. The genome sequence of C. sojina is a valuable resource with potential in studying the fungal pathogenicity and soybean host resistance to frogeye leaf spot (FLS), which is caused by C...
June 2017: Genomics Data
https://www.readbyqxmd.com/read/28383556/synovial-cell-death-is-regulated-by-tnf-%C3%AE-induced-expression-of-b-cell-activating-factor-through-an-erk-dependent-increase-in-hypoxia-inducible-factor-1%C3%AE
#12
Jae-Wook Lee, Jiyoung Lee, Sung Hee Um, Eun-Yi Moon
B-cell activating factor (BAFF) has a role in the maturation and maintenance of B cells and is associated with rheumatoid arthritis (RA). Here, we investigated whether tumor necrosis factor (TNF)-α-induced BAFF expression controls the survival of fibroblast-like synoviocytes (FLS) and whether their survival can be regulated by TNF-α-mediated upregulation of hypoxia-inducible factor (HIF)-1α using MH7A synovial cells transfected with the SV40 T antigen. More TNF-α-treated cells died compared with the control...
April 6, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28380935/graphene-q-switched-distributed-feedback-fiber-lasers-with-narrow-linewidth-approaching-the-transform-limit
#13
B C Yao, Y J Rao, S W Huang, Y Wu, Z Y Feng, C Choi, H Liu, H F Qi, X F Duan, G D Peng, C W Wong
A compact all-in-line graphene-based distributed feedback Bragg-grating fiber laser (GDFB-FL) with narrow linewidth of hundreds kHz is demonstrated and investigated in this study. Performing as an optical saturable absorber, graphene oscillates the initially kHz linewidth DFB-FL, and generates high-quality passively Q-switched pulses. Pumped with a 980 nm continuous-wave laser, the Q-switched GDFB-FL observes ~1 μs pulse durations, with pulse energies up to ~10 nJ and approaching the transform limit. The peak power is ~600 times higher than the original DFB-FL laser...
April 3, 2017: Optics Express
https://www.readbyqxmd.com/read/28371130/recommendations-on-the-implementation-of-genetic-algorithms-for-the-directed-evolution-of-enzymes-for-industrial-purposes
#14
Mark Howard Barley, Nicholas Turner, Roy Goodacre
Within Directed Evolution the assessment of candidate enzymes and their modification is essential. In this study we investigate Genetic Algorithms (GAs) within this context and conduct a systematic study of the behavior of GAs on 20 Fitness Landscapes (FLs) of varying complexity, which allowed the tuning of the GA to be explored. From this study recommendations for the best GA settings to use for a GA-directed High Throughput Experimental program (where populations and the number of generations is necessarily low) are reported...
March 29, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28365462/toward-understanding-the-role-of-cartilage-particulates-in-synovial-inflammation
#15
A M Silverstein, R M Stefani, E Sobczak, E L Tong, M G Attur, R P Shah, J C Bulinski, G A Ateshian, C T Hung
OBJECTIVE: Arthroscopy with lavage and synovectomy can remove tissue debris from the joint space and the synovial lining to provide pain relief to patients with osteoarthritis (OA). Here, we developed an in vitro model to study the interaction of cartilage wear particles with fibroblast-like synoviocytes (FLS) to better understand the interplay of cartilage particulates with cytokines on cells of the synovium. METHOD: In this study sub-10 μm cartilage particles or 1 μm latex particles were co-cultured with FLS ±10 ng/mL interleukin-1α (IL-1α) or tumor necrosis factor-α (TNF-α)...
March 30, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28337018/rheumatoid-arthritis-fibroblast-like-synoviocyte-suppression-mediated-by-pten-involves-survivin-gene-silencing
#16
Danna Chen, Dongdong Liu, Dan Liu, Min He, Anping Peng, Jiarui Xu, Li Lin, Fudong Luo, Lin Chen, Xianzhang Huang, Junhua Zhuang, Jianhua Xu
Survivin is a proto-oncogene biomarker known for its anti-apoptotic and cell cycle regulating properties induced by the activation of the phosphoinositide 3-kinase (PI3K)/Akt pathway. In the context of non-cancer pathology, such as rheumatoid arthritis (RA), survivin has emerged as a feature associated with severe joint damage and poor treatment response. Phosphatase and tensin homolog (PTEN) is a phosphatase antagonizing all classes of PI3K. The interplay between survivin oncogenic mechanisms and proliferation suppression networks in RA has remained largely elusive...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28330247/production-of-glucosinolates-phenolic-compounds-and-associated-gene-expression-profiles-of-hairy-root-cultures-in-turnip-brassica-rapa-ssp-rapa
#17
Ill-Min Chung, Kaliyaperumal Rekha, Govindasamy Rajakumar, Muthu Thiruvengadam
Turnip (Brassica rapa ssp. rapa) is an important vegetable crop producing glucosinolates (GSLs) and phenolic compounds. The GSLs, phenolic compound contents and transcript levels in hairy root cultures, as well as their antioxidant, antimicrobial and anticancer activity were studied in turnip. Transgenic hairy root lines were confirmed by polymerase chain reaction (PCR) and reverse transcription-PCR. GSLs levels (glucoallysin, glucobrassicanapin, gluconasturtiin, glucobrassicin, 4-methoxyglucobrassicin, neoglucobrassicin and 4-hydroxyglucobrassicin) and their gene expression levels (BrMYB28, BrMYB29, BrMYB34, BrMYB51, BrMYB122, CYP79 and CYP83) significantly increased in hairy roots compared with that in non-transformed roots...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28321538/microrna-192-suppresses-cell-proliferation-and-induces-apoptosis-in-human-rheumatoid-arthritis-fibroblast-like-synoviocytes-by-downregulating-caveolin-1
#18
Supin Li, Zhenmu Jin, Xiaobing Lu
Fibroblast-like synoviocytes (FLSs) play an important role in the pathogenesis of rheumatoid arthritis (RA). This study was conducted to explore the role of microRNA (miR)-192 in the regulation of the biology of RA-FLSs. The expression of miR-192 in RA and healthy synovial tissues was measured. The effects of overexpression of miR-192 on RA-FLS proliferation and apoptosis were investigated. Luciferase reporter assay and Western blot analysis were performed to identify direct target genes of miR-192. RA synovial tissues had significantly lower levels of miR-192 than healthy controls (P = 0...
March 20, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28314223/gv1001-immunotherapy-ameliorates-joint-inflammation-in-a-murine-model-of-rheumatoid-arthritis-by-modifying-collagen-specific-t-cell-responses-and-downregulating-antigen-presenting-cells
#19
In Ah Choi, Ji Yong Choi, Sundo Jung, Fathihah Basri, Seho Park, Eun Young Lee
This study investigated whether GV1001 may be useful for treating rheumatoid arthritis (RA). Two collagen-induced arthritis (CIA) experiments showed that therapeutic, but not preventive, GV1001 treatment reduced the severity of joint inflammation in CIA. The third CIA experiment indicated that, compared to vehicle treatment, therapeutic GV1001 treatment was associated with a significantly smaller area under the curve for the overall clinical joint score over the 98day observation period (p<0.05). GV1001 treatment was also associated with lower Day 98 serum IL-6 levels (p<0...
March 14, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28298375/knee-and-hip-intra-articular-adipose-tissues-iaats-compared-with-autologous-subcutaneous-adipose-tissue-a-specific-phenotype-for-a-central-player-in-osteoarthritis
#20
Florent Eymard, Audrey Pigenet, Danièle Citadelle, Joan Tordjman, Louise Foucher, Cindy Rose, Charles-Henri Flouzat Lachaniette, Christine Rouault, Karine Clément, Francis Berenbaum, Xavier Chevalier, Xavier Houard
OBJECTIVES: Compared with subcutaneous adipose tissue (SCAT), infrapatellar fat pad (IFP), the main knee intra-articular adipose tissue (IAAT), has an inflammatory phenotype in patients with osteoarthritis (OA). We phenotyped suprapatellar fat pad (SPFP) and hip acetabular fat pad (AFP), two other IAATs, to determinate the unique signature of IAATs compared with SCAT. METHODS: IFP, SPFP, AFP and autologous SCAT were obtained from patients with OA during total knee (n=38) or hip replacement (n=5)...
March 15, 2017: Annals of the Rheumatic Diseases
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