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https://www.readbyqxmd.com/read/29349543/saving-robots-improves-laparoscopic-performance-transfer-of-skills-from-a-serious-game-to-a-virtual-reality-simulator
#1
Wouter M IJgosse, Harry van Goor, Jan-Maarten Luursema
BACKGROUND: Residents find it hard to commit to structural laparoscopic skills training. Serious gaming has been proposed as a solution on the premise that it is effective and more motivating than traditional simulation. We establish construct validity for the laparoscopic serious game Underground by comparing laparoscopic simulator performance for a control group and an Underground training group. METHODS: A four-session laparoscopic basic skills course is part of the medical master students surgical internship at the Radboud University Medical Centre...
January 18, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29342969/feature-fusion-of-icp-aes-uv-vis-and-ft-mir-for-origin-traceability-of-boletus-edulis-mushrooms-in-combination-with-chemometrics
#2
Luming Qi, Honggao Liu, Jieqing Li, Tao Li, Yuanzhong Wang
Origin traceability is an important step to control the nutritional and pharmacological quality of food products. Boletus edulis mushroom is a well-known food resource in the world. Its nutritional and medicinal properties are drastically varied depending on geographical origins. In this study, three sensor systems (inductively coupled plasma atomic emission spectrophotometer (ICP-AES), ultraviolet-visible (UV-Vis) and Fourier transform mid-infrared spectroscopy (FT-MIR)) were applied for the origin traceability of 192 mushroom samples (caps and stipes) in combination with chemometrics...
January 15, 2018: Sensors
https://www.readbyqxmd.com/read/29328500/lair-1-shedding-from-human-fibroblast-like-synoviocytes-in-rheumatoid-arthritis-following-tnf-%C3%AE-stimulation
#3
Yuan Zhang, Song Wang, Haiying Dong, Xin Yi, Jinxue Zhang, Xueqin Liu, Ran Zhuang, Yong Ding
This study examined the expression of the inhibitory receptor, leukocyte-associated immunoglobulin (Ig)-like receptor-1 (LAIR-1) in fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA) patients to investigate its potential role in the modulation of inflammatory cytokines, metalloproteinases (MMPs), and invasiveness of synoviocytes. LAIR-1 expression in synovial tissues from RA patients, osteoarthritis patients, and healthy donors was analyzed by immunohistochemistry. The membrane-bound form (mLAIR-1) was detected by flow cytometry...
January 12, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29318481/transient-receptor-potential-ankyrin-1-trpa1-mediates-lipopolysaccharide-lps-induced-inflammatory-responses-in-primary-human-osteoarthritic-fibroblast-like-synoviocytes
#4
Songjiang Yin, Peimin Wang, Runlin Xing, Linrui Zhao, Xiaochen Li, Li Zhang, Yancheng Xiao
Transient receptor potential ankyrin 1 (TRPA1) is a membrane-associated cation channel, widely expressed in neuronal and non-neuronal cells. Recently, emerging evidences suggested the crucial role of TRPA1 in the disease progression of osteoarthritis (OA). Therefore, we aimed to investigate whether TRPA1 mediate lipopolysaccharide (LPS)-induced inflammatory responses in primary human OA fibroblast-like synoviocytes (OA-FLS). The expression of TRPA1 in LPS-treated OA-FLS was assessed by polymerase chain reaction (PCR) and western blot (WB), and the functionality of TRPA1 channel by Ca2+ influx measurements...
January 9, 2018: Inflammation
https://www.readbyqxmd.com/read/29318369/the-incidence-of-biopsy-proven-transformation-in-follicular-lymphoma-in-the-rituximab-era-a-retrospective-analysis-from-the-czech-lymphoma-study-group-clsg-database
#5
Andrea Janikova, Zbynek Bortlicek, Vit Campr, Natasa Kopalova, Katerina Benesova, Michaela Hamouzova, David Belada, Vit Prochazka, Robert Pytlik, Samuel Vokurka, Jan Pirnos, Juraj Duras, Heidi Mocikova, Jiri Mayer, Marek Trneny
The aim of this study is to assess the incidence, risk factors, and outcome of biopsy-proven transformation in follicular lymphoma (FL) patients in the rituximab era. Transformation was analyzed in 1233 patients with initially diagnosed FL grades 1-3A, identified between 2002 and 2012 in the prospectively maintained Czech Lymphoma Study Group database. Only patients with histologically proven transformation (HT) were included. HT occurred in 58 cases at a median of 3.0 years from the initial FL diagnosis; the HT rate was 4% at 5 years...
January 9, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29315644/solar-uv-light-regulates-flavonoid-metabolism-in-apple-malus-x-domestica
#6
Rebecca A Henry-Kirk, Blue Plunkett, Miriam Hall, Tony McGhie, Andrew C Allan, Jason J Wargent, Richard V Espley
Ultraviolet-B light (UV-B) is one environmental signal perceived by plants that affects the flavonoid pathway and influences the levels of anthocyanins, flavonols and proanthocyanidins. To understand the mechanisms underlying UV exposure, apple trees were grown under spectral filters that altered transmission of solar UV light. Fruit analysis showed that UV induced changes in physiology, metabolism and gene expression levels during development over a season. These changes were sustained after storage. Under low UV ripening was delayed, fruit size decreased, and anthocyanin and flavonols were reduced...
January 6, 2018: Plant, Cell & Environment
https://www.readbyqxmd.com/read/29310668/prior-to-extension-transcriptomes-of-fibroblast-like-synoviocytes-from-extended-and-polyarticular-juvenile-idiopathic-arthritis-are-indistinguishable
#7
AnneMarie C Brescia, Megan M Simonds, Suzanne M McCahan, Kathleen E Sullivan, Carlos D Rose
BACKGROUND: Our intent was to identify differences between the transcriptome of fibroblast-like synoviocytes (FLS) in oligoarticular juvenile idiopathic arthritis (JIA) before extension when compared to persistent subtype of JIA, when the two are clinically indistinguishable. Additionally, we sought to determine if differences between the transcriptomes of FLS from extended-to-be and polyarticular course JIA could be detected. Our hypothesis was that intrinsic differences in the transcriptome of the FLS from extended-to-be JIA would distinguish them from persistent oligoarticular JIA, before the course is clinically apparent...
January 8, 2018: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/29306209/retinoid-interferon-induced-mortality19-grim19-inhibits-proliferation-and-invasion-in-rheumatoid-arthritis-fibroblast-like-synoviocytes
#8
Dongkai Zhao, Zhiyu Jiang, Zhihui Wang, Jinliang Gao
Rheumatoid arthritis (RA) fibroblast-like synoviocytes (RA-FLS) are reportedly involved in RA initiation, progression, and perpetuation. Previously a study showed that retinoid interferon-induced mortality 19 (GRIM19) improved the clinical and histological features of collagen-induced arthritis (CIA),and also inhibited osteoclast formation. However, the role of GRIM19 in RA-FLS remains unclear. In this study, we explored the biological function and underlying mechanism of GRIM19 in cultured RA-FLS. The expression of GRIM19 in synovial tissues and RA-FLS was detected by real-time quantitative RT-PCR(qRT-PCR)...
January 3, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29306173/blocking-osteopontin-fibronectin-interactions-reduce-extracellular-fibronectin-deployment-and-arthritic-immunopathology
#9
Brij Bhushan Mehta, Saniya Sharma, Rakesh K Vasishta, Ramesh K Sen, Aman Sharma, Manni Luthra-Guptasarma
Elevated levels of a thrombin-cleaved fragment of osteopontin (OPNT) are seen in synovial fluid (SF) and tissues of rheumatoid arthritis (RA) patients. OPNT binds to integrins on cell surfaces, inducing adhesion, migration and survival of inflammatory cells in the synovial joints, where OPNT binds to fibronectin to link fibroblast-like synoviocytes (FLS) with B cells, stimulating the latter to produce inflammatory cytokines. Our aim was to block OPNT-fibronectin interactions and examine whether this reduces inflammation...
January 3, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29301931/translocator-protein-as-an-imaging-marker-of-macrophage-and-stromal-activation-in-ra-pannus
#10
Nehal Narayan, David Owen, Harpreet Mandhair, Erica Smyth, Francesco Carlucci, Azeem Saleem, Roger Gunn, Eugenii Ilan A Rabiner, Lisa Wells, Stephanie Dakin, Afsie Sabokbar, Peter Taylor
Positron Emission Tomography (PET) radioligands targeted to Translocator protein (TSPO), offer a highly sensitive and specific means of imaging joint inflammation in rheumatoid arthritis (RA). Through high expression of TSPO on activated macrophages, TSPO PET has been widely reported in several studies of RA as a means of imaging synovial macrophages in vivo. However, this premise does not take into account the ubiquitous expression of TSPO. This study aimed to investigate TSPO expression in major cellular constituents of RA pannus; monocytes, macrophages, fibroblast-like synoviocytes (FLS) and CD4+ T lymphocytes, to more accurately interpret TSPO PET signal from RA synovium...
January 4, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29301301/immunosuppressive-effect-of-geniposide-on-mitogen-activated-protein-kinase-signalling-pathway-and-their-cross-talk-in-fibroblast-like-synoviocytes-of-adjuvant-arthritis-rats
#11
Feng Li, Miaomiao Dai, Hong Wu, Ran Deng, Jun Fu, Zhengrong Zhang, Li Dai, Wenyu Wang, Xuejing Dai, Xiang Zhan, Yan Wang
Geniposide (GE), an iridoid glycoside compound derived from Gardenia jasminoides Ellis fruit, is known to have anti-inflammatory and immunoregulatory activities. The aim of this study was to investigate the protective mechanism of GE in the regulation of the mitogen-activated protein kinase (MAPK) signalling pathway and the cross-talk among the MAPK signalling pathway in fibroblast-like synoviocytes (FLS) of adjuvant arthritis (AA) rats. AA was induced by injecting with Freund's complete adjuvant. Male SD rats and FLS were subjected to treatment with GE (30, 60 and 120 mg/kg) in vivo from day 14 to 21 after immunization and GE (25, 50 and 100 μg/mL) in vitro, respectively...
January 2, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29287304/the-tumor-like-phenotype-of-rheumatoid-synovium-molecular-profiling-and-prospects-for-precision-medicine
#12
REVIEW
Sungyong You, Jung Hee Koh, Lin Leng, Wan-Uk Kim, Richard Bucala
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by a destructive hyperplasia of synovium. Fibroblast-like synoviocytes (FLS) are a major component of synovial pannus and actively participate in the pathologic progression of RA. How rheumatoid FLS acquire and sustain such a uniquely aggressive phenotype remains poorly understood. We describe the current state of knowledge of the molecular alterations in rheumatoid FLS at the genomic, epigenomic, transcriptomic, proteomic, and metabolomic levels, which offers a comprehensive and complementary reconstruction of the potential pathways leading to rheumatoid pannus...
December 29, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29285627/fracture-liaison-services-for-osteoporosis-in-the-asia-pacific-region-current-unmet-needs-and-systematic-literature-review
#13
REVIEW
Y -F Chang, C -F Huang, J -S Hwang, J -F Kuo, K -M Lin, H -C Huang, S Bagga, A Kumar, F -P Chen, C -H Wu
The analysis aimed to identify the treatment gaps in current fracture liaison services (FLS) and to provide recommendations for best practice establishment of future FLS across the Asia-Pacific region. The findings emphasize the unmet need for the implementation of new programs and provide recommendations for the refinement of existing ones. The study's objectives were to evaluate fracture liaison service (FLS) programs in the Asia-Pacific region and provide recommendations for establishment of future FLS programs...
December 28, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29260291/a-dedicated-fracture-liaison-service-telephone-program-and-use-of-bone-turnover-markers-for-evaluating-1-year-persistence-with-oral-bisphosphonates
#14
P van den Berg, P M M van Haard, E van der Veer, P P Geusens, J P van den Bergh, D H Schweitzer
Telephone call intervention did not improve alendronate persistence in Fracture Liaison Service (FLS) patients in this study. A bone turnover marker cut-off point for alendronate persistence is proposed for individual FLS patients. INTRODUCTION: FLS aims to prevent subsequent fractures, which should include improving patients' persistence with prescribed oral bisphosphonates. We studied the influence of telephone calls and the predictive value of changes in bone turnover markers (BTMs) for evaluating persistence with alendronate...
December 19, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29241159/oxymatrine-prevents-synovial-inflammation-and-migration-via-blocking-nf-%C3%AE%C2%BAb-activation-in-rheumatoid-fibroblast-like-synoviocytes
#15
Jiang Liang, Boyang Chang, Mingcheng Huang, Weichen Huang, Wukai Ma, Yang Liu, Wan Tai, Yi Long, Yun Lu
The fibroblast-like synoviocytes (FLSs) has the aggressive phenotype, which is very important for cartilage destruction in rheumatoid arthritis (RA). To the pathology of RA, the increased FLSs migration, activation and proliferation are essential factors. Oxymatrine is a traditional Chinese herb, which is the extraction from the root of Sophora flavescens and regarded as quinolizidine alkaloid compounds and has been shown to inhibit inflammation, proliferation and migration in vitro or vivo. However, whether oxymatrine effects in the treatment of RA FLSs is undefined...
December 11, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29236318/proliferation-and-apoptosis-of-rheumatoid-arthritis-fibroblast-like-synoviocytes-following-signal-transducer-and-activator-of-transcription-3-rna-interference-delivery
#16
Xuehui Sun, Yun Han, Ying Liu, Yanchun Tang, Jibo Wang
OBJECTIVE: In this study, we investigated the effects of delivering small interfering RNA (siRNA) for efficient STAT3 downregulation on propagation and apoptosis of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS). METHODS: The FLSs were transfected with three different siRNAs. RNAi-1 was selected for further experiments. The expression levels of both STAT3 mRNA and its protein were detected by RT-PCR and western blot. The proliferation of FLSs was examined by MTT assay...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29230540/preventing-future-fractures-effectiveness-of-an-orthogeriatric-fracture-liaison-service-compared-to-an-outpatient-fracture-liaison-service-and-the-standard-management-in-patients-with-hip-fracture
#17
Antonio Naranjo, Sonia Fernández-Conde, Soledad Ojeda, Laura Torres-Hernández, Carolina Hernández-Carballo, Idoia Bernardos, Sinforiano Rodríguez, Pedro Laynez
An observational study was carried out in two hospitals in patients > 65 years admitted for hip fracture. At 6 months, 15% of patients in the hospital with orthogeriatric standard care and 75% in the hospital with fracture liaison service were receiving bisphosphonates. PURPOSE: Many patients with fractures are discharged without preventive therapy against further fractures. We sought to compare the effectiveness of an orthogeriatric fracture liaison service (FLS), outpatient FLS, and the standard care after hip fractures in prevention of future fractures...
December 11, 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29228301/targeted-inhibition-of-janus-kinases-abates-interfon-gamma-induced-invasive-behaviour-of-fibroblast-like-synoviocytes
#18
Thomas Karonitsch, Denise Beckmann, Karolina Dalwigk, Birgit Niederreiter, Paul Studenic, Ruth A Byrne, Johannes Holinka, Florian Sevelda, Adelheid Korb-Pap, Günter Steiner, Josef S Smolen, Thomas Pap, Hans P Kiener
Objectives: The aim was to explore the function of the T-cell cytokine IFNγ for mesenchymal tissue remodelling in RA and to determine whether IFNγ signalling controls the invasive potential of fibroblast-like synoviocytes (FLS). Methods: To assess architectural responses, FLS were cultured in three-dimensional micromasses. FLS motility was analysed in migration and invasion assays. Signalling events relevant to cellular motility were defined by western blots. Baricitinib and small interfering RNA pools were used to suppress Janus kinase (JAK) functions...
December 7, 2017: Rheumatology
https://www.readbyqxmd.com/read/29226428/predictive-value-of-18-f-fdg-pet-ct-scanning-in-combination-with-clinical-parameters-in-patients-with-newly-diagnosed-multiple-myeloma
#19
Honglei Tu, Yong He, Tianhe Huang, Songguk Choe, Xiaoli Lan, Xiaoyi Duan, Haseeb Sattar, Chongjiao Li, Fuling Zhou
OBJECTIVE: To evaluate the association of 18 F-2'-deoxy 2'-fluorodeoxyglucose (18 F-FDG) PET/CT with clinical parameters in predicting patients with newly diagnosed multiple myeloma (MM). METHODS: 120 MM patients undergoing 18 F-FDG PET/CT scanning were analyzed in a retrospective cohort study. RESULTS: Based on multivariate analysis, β2M, LDH, number of focal lesions (FLs) and SUVmax were significantly correlated with OS. These 4 variables were used to construct a new staging system (NSS) based on the number of risk factors...
December 11, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/29226077/leptin-induced-migration-and-angiogenesis-in-rheumatoid-arthritis-is-mediated-by-reactive-oxygen-species
#20
Xiaotong Sun, Jing Wei, Yawei Tang, Bing Wang, Yan Zhang, Lei Shi, Jianping Guo, Fanlei Hu, Xia Li
Rheumatoid arthritis (RA) is a progressive autoimmune disease affecting the joints. In this study, we investigated the role of the pro-angiogenic factor leptin in regulating reactive oxygen species (ROS) to promote cell migration and angiogenesis in RA. We showed that leptin triggered RA fibroblast-like synoviocyte (FLS) migration by increased ROS expression. Additionally, leptin enhanced human umbilical vein endothelial cell (HUVEC) tube formation in a ROS/hypoxia-inducible factor-1α-dependent manner, accompanied by increased production of vascular endothelial growth factor and interleukin (IL)-6...
December 2017: FEBS Open Bio
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