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https://www.readbyqxmd.com/read/29782431/the-influence-of-3d-in-single-port-laparoscopy-surgery-an-experimental-study
#1
Jaime Vilaça, Mariana Leite, Jorge Correia-Pinto, Gerrit Högemann, Patrício Costa, Pedro Leão
The aim of this experimental study was to analyze the effect of 3-dimensional (3D) imaging in laparoendoscopic single-site surgery. End points were time, errors, and preference. Twenty-six participants were enrolled in the study, and these were divided into Beginners and Experts, in exercises either with a 2-dimensional or a 3D system. The 4 phantom exercises were chosen from the E-BLUS-European Training in Basic Laparoscopic Urological Skills from the American Fundamentals of Laparoscopic Surgery (FLS) system...
May 18, 2018: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/29779214/cyanidin-3-glucoside-inhibits-inflammatory-activities-in-human-fibroblast-like-synoviocytes-and-in-mice-with-collagen-induced-arthritis
#2
Yan Sun, Lingling Li
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint tissue inflammation. Cyanidin-3-glucoside (C3G) is a major component in the flavonoid family and has shown anti-inflammatory, anti-oxidant and anti-tumor activity. In this study, we investigated the effects of C3G on lipopolysaccharides (LPS)-induced inflammation on human rheumatoid fibroblast-like synoviocytes (FLS) and on collagen-induced arthritis (CIA) mice model. We treated FLS with C3G followed by LPS induction, the expressions of tumor necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β) and IL-6 and the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathway were analyzed...
May 19, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29777367/effects-of-crocin-on-inflammatory-activities-in-human-fibroblast-like-synoviocytes-and-collagen-induced-arthritis-in-mice
#3
Longjie Li, Haiseng Zhang, Shengli Jin, Chang Liu
Rheumatoid arthritis (RA) is a systemic autoimmune disease, characterized by the irreversible joint destruction resulted from the attack of inflammatory cells to the joints. Recent studies demonstrated that crocin is able to alleviate arthritis and suppress inflammatory responses, implying crocin as a potential promising antiarthritic agent. In this study, we confirmed the effect of crocin on RA and revealed its underlying mechanism by measuring lipopolysaccharides (LPS)-stimulated cytokine production in presence or absence of crocin...
May 18, 2018: Immunologic Research
https://www.readbyqxmd.com/read/29777356/visuospatial-abilities-and-fine-motor-experiences-influence-acquisition-and-maintenance-of-fundamentals-of-laparoscopic-surgery-fls-task-performance
#4
Cuan M Harrington, Patrick Dicker, Oscar Traynor, Dara O Kavanagh
BACKGROUND: Minimally invasive surgery poses a unique learning curve due to the requirement for non-intuitive psychomotor skills. The fundamentals of laparoscopic surgery (FLS) program trains and certifies residents in such skills. However, innate predictors of FLS performance and maintenance remain to be described. This single-centre observational study aimed to assess for candidate factors influencing the acquisition and maintenance of FLS performance amongst a surgically naïve cohort...
May 18, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29775214/pressurized-hot-water-extraction-of-bioactive-compounds-from-artichoke-by-products
#5
Imma Pagano, Anna Lisa Piccinelli, Rita Celano, Luca Campone, Patrizia Gazzerro, Mariateresa Russo, Luca Rastrelli
Artichoke by-products are a suitable source of health-promoting ingredients for the production of dietary supplements and food additives. A pressurized hot water extraction (PHWE) was developed to recover caffeoylquinic acids (CQAs) and flavone glycosides (FLs) from agro-industrial artichoke by-products. The main factors influencing PHWE efficiency and CQA isomerization (temperature, numbers of cycles, modifier and extraction time) were carefully studied and optimized by response surface design. The proposed PHWE procedure provides an exhaustive extraction of CQAs and FLs (recoveries: 93-105 and 90-105%) from artichoke external bracts and leaves of different cultivars (p > 0...
May 18, 2018: Electrophoresis
https://www.readbyqxmd.com/read/29768212/mtor-senses-environmental-cues-to-shape-the-fibroblast-like-synoviocyte-response-to-inflammation
#6
Thomas Karonitsch, Richard K Kandasamy, Felix Kartnig, Barbara Herdy, Karolina Dalwigk, Birgit Niederreiter, Johannes Holinka, Florian Sevelda, Reinhard Windhager, Martin Bilban, Thomas Weichhart, Marcus Säemann, Thomas Pap, Günter Steiner, Josef S Smolen, Hans P Kiener, Giulio Superti-Furga
Accumulating evidence suggests that metabolic master regulators, including mTOR, regulate adaptive and innate immune responses. Resident mesenchymal tissue components are increasingly recognized as key effector cells in inflammation. Whether mTOR also controls the inflammatory response in fibroblasts is insufficiently studied. Here, we show that TNF signaling co-opts the mTOR pathway to shift synovial fibroblast (FLS) inflammation toward an IFN response. mTOR pathway activation is associated with decreased NF-κB-mediated gene expression (e...
May 15, 2018: Cell Reports
https://www.readbyqxmd.com/read/29765031/comprehensive-epigenetic-landscape-of-rheumatoid-arthritis-fibroblast-like-synoviocytes
#7
Rizi Ai, Teresina Laragione, Deepa Hammaker, David L Boyle, Andre Wildberg, Keisuke Maeshima, Emanuele Palescandolo, Vinod Krishna, David Pocalyko, John W Whitaker, Yuchen Bai, Sunil Nagpal, Kurtis E Bachman, Richard I Ainsworth, Mengchi Wang, Bo Ding, Percio S Gulko, Wei Wang, Gary S Firestein
Epigenetics contributes to the pathogenesis of immune-mediated diseases like rheumatoid arthritis (RA). Here we show the first comprehensive epigenomic characterization of RA fibroblast-like synoviocytes (FLS), including histone modifications (H3K27ac, H3K4me1, H3K4me3, H3K36me3, H3K27me3, and H3K9me3), open chromatin, RNA expression and whole-genome DNA methylation. To address complex multidimensional relationship and reveal epigenetic regulation of RA, we perform integrative analyses using a novel unbiased method to identify genomic regions with similar profiles...
May 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29761884/inhibitory-effects-of-tubeimoside-i-on-synoviocytes-and-collagen-induced-arthritis-in-rats
#8
Zhenzhou Liu, Lin Zhou, Xuemei Ma, Shengnan Sun, Haiwen Qiu, Hui Li, Jiake Xu, Mei Liu
Advancements in rheumatoid arthritis (RA) therapies have shown considerable progresses in the comprehension of disease. However, the development of new potential medicines with relative safety and efficacy continues and natural compounds have been considered as alternatives or complementary agents to gain immense attractions. Tubeimoside I (TBMS I), a main triterpenoid saponin isolated from Bolbostemma paniculatum, has been reported to possess antiviral and anticancer effects. However, its effect on RA remains unknown...
May 15, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29755657/regulatory-effect-of-anti-gp130-functional-mab-on-il-6-mediated-rankl-and-wnt5a-expression-through-jak-stat3-signaling-pathway-in-fls
#9
Ping Miao, Xiao Wei Zhou, Ping Wang, Rong Zhao, Ninan Chen, Chao Ying Hu, Xue Hua Chen, Liu Qian, Qi Wen Yu, Ji Ying Zhang, Rong Xu, Dong Yi He, Lian Bo Xiao, Pu Li, Mason Lu, Dong Qing Zhang
We investigated the effect on rheumatoid arthritis (RA) of an anti-gp130 monoclonal antibody (mAb) and its mechanism using RA fibroblast-like synoviocytes (FLS) and a collagen antibody-induced arthritis (CAIA) mouse model. We determined the interleukin 6 (IL-6), IL-6 receptor α (IL-6Rα), gp130, receptor activator of nuclear factor κB ligand (RANKL), matrix metalloproteinase 3 (MMP3), TIMP metallopeptidase inhibitor 1 (TIMP1), and Bcl-2 levels in RA and osteoarthritis (OA) serum and synovial fluid. RA FLS were cultured with or without IL-6/IL-6Rα; WNT5A and RANKL levels were detected...
April 17, 2018: Oncotarget
https://www.readbyqxmd.com/read/29754189/consensus-on-best-practice-standards-for-fracture-liaison-service-in-the-asia-pacific-region
#10
Ding-Cheng Derrick Chan, Lo-Yu Chang, Kristina E Akesson, Paul Mitchell, Chung-Hwan Chen, E Michael Lewiecki, Joon Kiong Lee, Tang Ching Lau, Thawee Songpatanasilp, Kin Bong Lee, Kwang Joon Kim, Jung-Fu Chen, Ko-En Huang, Yih-Lan Gau, Yin-Fan Chang, Peter Ebeling, Weibo Xia, Wei Yu, Atsushi Suzuki, Fen Lee Hew, Leilani B Mercado-Asis, Yoon-Sok Chung, Keh-Sung Tsai, Gau-Tyan Lin, Rong-Sen Yang, Chih-Hsing Wu
The Fracture Liaison Service (FLS) Consensus Meeting endorsed by the International Osteoporosis Foundation (IOF), Asian Federation of Osteoporosis Societies (AFOS), and Asia Pacific Osteoporosis Foundation (APOF) was hosted by the Taiwanese Osteoporosis Association on October 14, 2017. International and domestic experts reviewed the 13 Best Practice Framework (BPF) standards and concluded that all standards were generally applicable in the Asia-Pacific region and needed only minor modifications to fit the healthcare settings in the region...
May 12, 2018: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29748156/tl1a-mediates-fibroblast-like-synoviocytes-migration-and-indian-hedgehog-signaling-pathway-via-tnfr2-in-patients-with-rheumatoid-arthritis
#11
Mahmoud Al-Azab, Jing Wei, Xunli Ouyang, Abdalkhalig Elkhider, Williams Walana, Xiaotong Sun, Yawei Tang, Bing Wang, Xia Li
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joints inflammation. One of the aggressive characteristics of RA fibroblast-like synoviocytes (FLS) is the tendency for migration in the local environment, which plays a central role in the RA pathogenesis. Tumor Necrosis Factor (TNF)-like cytokine 1A (TL1A) is a member of TNF superfamily, which has a role in autoimmunity and influences the RA-FLS behavior through TNF receptor 2 (TNFR2). We investigated the effect of TNF-like cytokine 1A (TL1A) on RA-FLS migration using patients' samples...
March 1, 2018: European Cytokine Network
https://www.readbyqxmd.com/read/29747415/patient-related-factors-associated-with-adherence-to-recommendations-made-by-a-fracture-liaison-service-a-mixed-method-prospective-study
#12
Mireille Luc, Hélène Corriveau, Gilles Boire, Johanne Filiatrault, Marie-Claude Beaulieu, Isabelle Gaboury
A Fracture Liaison Service (FLS) has been calculated to be a cost-effective model of care for patients with fragility fracture (FF). Cost-effectiveness can be achieved when adherence to bone health recommendations from FLS staff is high. This prospective study combined participants’ telephone longitudinal survey data (intervention group, n = 354) and interviews with 16 individuals from FLS in three health regions of the province of Quebec (Canada). Participants were recruited between January 2013 and April 2015...
May 9, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29743895/osthole-improves-collagen-induced-arthritis-in-a-rat-model-through-inhibiting-inflammation-and-cellular-stress
#13
Renguo Xu, Zhen Liu, Jiande Hou, Tao Huang, Ming Yang
Background: Osthole is a natural product that has multiple bioactive functions and has been reported to exert potent immunosuppressive effects. However, the therapeutic effect of osthole on arthritis has not been explored. In the present study, a collagen-induced arthritis rat model, IL-1β-stimulated SW982 cells, and RA-like fibroblast-like synoviocytes (FLS) were employed to investigate the effect and possible mechanism of osthole on arthritis in vivo and in vitro. Results: 20 and 40 mg/kg osthole significantly alleviated collagen-induced arthritic symptoms based on histopathology and clinical arthritis scores, and improved erosion using HE staining...
2018: Cellular & Molecular Biology Letters
https://www.readbyqxmd.com/read/29731996/microrna-signatures-and-foxp3-cell-count-correlate-with-relapse-occurrence-in-follicular-lymphoma
#14
Giorgio Malpeli, Stefano Barbi, Corinna Greco, Simonetta Zupo, Anna Bertolaso, Maria Teresa Scupoli, Mauro Krampera, Paul Takam Kamga, Carlo Maria Croce, Aldo Scarpa, Alberto Zamò
First line drug treatment of follicular lymphoma (FL) patients is followed by a highly variable disease-free time before relapse in about one third of patients. No molecular marker is able to predict efficiently the risk of relapse. We investigated the expression profile of microRNAs (miRNAs) by microarrays and of the tumor microenvironment by immunohistochemistry in 26 FLs and 12 reactive lymph nodes (rLN) as reference. Twenty-nine miRNAs were differentially expressed in FLs compared to rLNs and some of them discriminated grade 1 from 3a FLs...
April 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29727860/comparative-transcriptome-analysis-of-genes-involved-in-anthocyanin-synthesis-in-blueberry
#15
Yang Lin, Yuehua Wang, Bin Li, Hui Tan, Dongnan Li, Li Li, Xuan Liu, Jichen Han, Xianjun Meng
Blueberry (Vaccinium, family Ericaceae) is well known for its strong antioxidant properties and abundant active ingredients including anthocyanins, flavonols, and proanthocyanidins. In this study, variations in anthocyanin and phenolic compounds content in Bluecrop and Northblue blueberry cultivar fruits were studied, and comparative transcriptome analysis was performed to analyze differences in the molecular mechanisms of anthocyanin biosynthesis. A total of 13 799 unique genes were identified by differential expression analysis, and further subjected to GO classification and pathway enrichment...
April 26, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29717129/gata4-regulates-angiogenesis-and-persistence-of-inflammation-in-rheumatoid-arthritis
#16
Wanwan Jia, Weijun Wu, Di Yang, Chenxi Xiao, Mengwei Huang, Fen Long, Zhenghua Su, Ming Qin, Xinhua Liu, Yi Zhun Zhu
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by abnormal inflammation, angiogenesis, and cartilage destruction. In RA, neoangiogenesis is an early and crucial event to promote the formation of pannus, causing further inflammatory cell infiltration. The transcription factor GATA4 is a critical regulator of cardiac differentiation-specific gene expression. We find that a higher level of GATA4 exists in synovium of rheumatoid arthritis (RA) patients, but the function of GATA4 in RA remains unclear...
May 2, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29713439/ann-and-fuzzy-logic-based-model-to-evaluate-huntington-disease-symptoms
#17
Andrius Lauraitis, Rytis Maskeliūnas, Robertas Damaševičius
We introduce an approach to predict deterioration of reaction state for people having neurological movement disorders such as hand tremors and nonvoluntary movements. These involuntary motor features are closely related to the symptoms occurring in patients suffering from Huntington's disease (HD). We propose a hybrid (neurofuzzy) model that combines an artificial neural network (ANN) to predict the functional capacity level (FCL) of a person and a fuzzy logic system (FLS) to determine a stage of reaction. We analyzed our own dataset of 3032 records collected from 20 test subjects (both healthy and HD patients) using smart phones or tablets by asking a patient to locate circular objects on the device's screen...
2018: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29709544/identification-and-suppression-of-epidermal-growth-factor-receptor-variant-iii-signaling-in-fibroblast-like-synoviocytes-from-aggressive-rheumatoid-arthritis-by-the-mimotope
#18
Jianying Niu, Changhong Li, Yinji Jin, Rui Xing, Lin Sun, Ruohan Yu, Leilei Jian, Xiangyuan Liu, Lin Yang
Epidermal growth factor receptor (EGFR) signaling has been reported to play a vital role in the pathogenesis of rheumatoid arthritis (RA). In current study, we sought to observe whether the active immunization induced by the mimotope could recognize EGFR, inhibit their signaling and disrupt the pathogenic behavior of fibroblast-like synoviocytes (FLS) from RA patients. We prepared a linked EGFR mimotope and performed series of experiments to detect whether the mimotope could induce the desired immune responses...
April 27, 2018: Immunology Letters
https://www.readbyqxmd.com/read/29706965/transcription-factor-sox5-promotes-the-migration-and-invasion-of-fibroblast-like-synoviocytes-in-part-by-regulating-mmp-9-expression-in-collagen-induced-arthritis
#19
Yumeng Shi, Qin Wu, Wenhua Xuan, Xiaoke Feng, Fang Wang, Betty P Tsao, Miaojia Zhang, Wenfeng Tan
Objectives: Fibroblast-like synoviocytes (FLS) exhibit a unique aggressive phenotype in rheumatoid arthritis (RA). Increased FLS migration and subsequent invasion of the extracellular matrix are essential to joint destruction in RA. Our previous research reported that transcription factor SOX5 was highly expressed in RA-FLS. Here, the effects of SOX5 in RA-FLS migration and invasion will be investigated. Methods: The migration and invasion of RA-FLS were evaluated using a transwell chamber assay...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29705333/shh-signaling-influences-the-phenotype-of-pitx1-hindlimbs
#20
Stephen Nemec, Aurélie Huang Sung, Jacques Drouin
Forelimbs (FLs) and hindlimbs (HLs) develop under the instructive and integrated guidance of signaling centers and transcription factor (TF) action. The development of structures specific to each limb type depends on the limb-specific modulation of these integrated components. Pitx1 is a transcription factor gene expressed in HL, absent in FL, and required for HL-specific patterning and development, in particular for formation of anterior HL skeletal elements. Pitx1 achieves this function by direct TF action on the core limb program, which is largely shared between FL and HL...
April 26, 2018: Developmental Biology
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