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Functional echocardiography

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https://www.readbyqxmd.com/read/29666587/cardioprotective-effects-of-qishenyiqi-dripping-pills-on-transverse-aortic-constriction-induced-heart-failure-in-mice
#1
Guoran Ruan, Haojin Ren, Chi Zhang, Xiaogang Zhu, Chao Xu, Liyue Wang
QiShenYiQi dripping pills (QSYQ), a traditional Chinese medicine, are commonly used to treat coronary heart disease, and QSYQ was recently approved as a complementary treatment for ischemic heart failure in China. However, only few studies reported on whether QSYQ exerts a protective effect on heart failure induced by pressure overload. In this study, we explored the role of QSYQ in a mouse model of heart failure induced by transverse aortic constriction (TAC). Twenty-eight C57BL/6J mice were divided into four groups: Sham + NS group, Sham + QSYQ group, TAC + NS group, and TAC + QSYQ group...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29666035/anemia-and-its-effect-on-cardiovascular-findings-in-obese-adolescents
#2
Öner Yıldırım, Tülay Demircan, Özlem Tüfekçi, Özgür Kızılca, Pınar Kuyum, Mustafa Kır, Ayhan Abacı, Nurettin Ünal, Nur Arslan, Ece Böber, Şebnem Yılmaz, Hale Ören
OBJECTIVE: We assessed the effect of anemia on cardiovascular findings in obese adolescents. MATERIALS AND METHODS: We studied 29 anemic, 33 nonanemic obese adolescents, and 33 nonobese healthy adolescents. These three groups were investigated for clinical and laboratory features of anemia and obesity. Echocardiography was used to examine cardiac functions. RESULTS: The anemia was mild (mean hemoglobin 11.67±0.79g/dL), ferritin level was significantly low, and CRP and fibrinogen levels were significantly high in anemic obese patients...
April 18, 2018: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/29664405/longitudinal-assessment-of-vascular-function-with-sunitinib-in-patients-with-metastatic-renal-cell-carcinoma
#3
Anna B Catino, Rebecca A Hubbard, Julio A Chirinos, Ray Townsend, Stephen Keefe, Naomi B Haas, Igor Puzanov, James C Fang, Neeraj Agarwal, David Hyman, Amanda M Smith, Mary Gordon, Theodore Plappert, Virginia Englefield, Vivek Narayan, Steven Ewer, Chantal ElAmm, Daniel Lenihan, Bonnie Ky
BACKGROUND: Sunitinib, used widely in metastatic renal cell carcinoma, can result in hypertension, left ventricular dysfunction, and heart failure. However, the relationships between vascular function and cardiac dysfunction with sunitinib are poorly understood. METHODS AND RESULTS: In a multicenter prospective study of 84 metastatic renal cell carcinoma patients, echocardiography, arterial tonometry, and BNP (B-type natriuretic peptide) measures were performed at baseline and at 3...
March 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29663996/-establishment-and-evaluation-of-mouse-models-of-septic-myocardial-injury
#4
Liya Hu, Peijun Li, Chao Chang, Shan Liu, Yanqiu Song, Fumei Zhao, Ting Liu
OBJECTIVE: Mouse models of sepsis-induced myocardial injury by intraperitoneal injection of lipopolysaccharide (LPS) was established in order to provide a reliable method for the research of pathogenesis of sepsis-induced myocardial injury. METHODS: According to the method of random number table, a total of 150 male C57BL/6 mice were divided into five groups: NC group, sham group, and LPS 10, 12, 15 mg/kg groups, with 30 in each group. Septic myocardial injury was induced by intraperitoneal injection LPS in mice; sham group was injected with equal 0...
April 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29663994/-predictive-value-of-early-phrase-echocardiography-and-cardiac-biological-markers-in-patients-with-severe-sepsis-a-five-year-single-center-retrospective-study
#5
Xuefeng Zang, Wei Chen, Bo Sheng, Lei Zhao, Xuyun Gu, Jie Zhen, Ping Liu
OBJECTIVE: To assess the predictive value of early phrase echocardiography and cardiac biomarkers in patients with severe sepsis. METHODS: A retrospective analysis of severe septic patients (patients with acute coronary syndrome and end stage renal disease were excluded) in department of intensive care unit of Capital Medical University Affiliated Beijing Shijitan Hospital from January 2013 to December 2017 was conducted. The acute physiology and chronic health evaluation II (APACHE II) score, N-terminal prohormone of brain natriuretic peptide (NT-proBNP), cardiac troponin I (cTnI), myoglobin (MYO), creatine kinase (CK), MB isoenzyme of creatine kinase (CK-MB) within 6 hours after admission, and bedside echocardiography indexes [left ventricular ejection fraction (LVEF), the ratio of the peak blood flow velocity in the early stage of the mitral valve and the peak blood flow rate of the mitral valve (E/A ratio)] within 6 hours after diagnosis were recorded...
April 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29661795/machine-learning-analysis-of-left-ventricular-function-to-characterize-heart-failure-with-preserved-ejection-fraction
#6
Sergio Sanchez-Martinez, Nicolas Duchateau, Tamas Erdei, Gabor Kunszt, Svend Aakhus, Anna Degiovanni, Paolo Marino, Erberto Carluccio, Gemma Piella, Alan G Fraser, Bart H Bijnens
BACKGROUND: Current diagnosis of heart failure with preserved ejection fraction (HFpEF) is suboptimal. We tested the hypothesis that comprehensive machine learning (ML) of left ventricular function at rest and exercise objectively captures differences between HFpEF and healthy subjects. METHODS AND RESULTS: One hundred fifty-six subjects aged >60 years (72 HFpEF+33 healthy for the initial analyses; 24 hypertensive+27 breathless for independent evaluation) underwent stress echocardiography, in the MEDIA study (Metabolic Road to Diastolic Heart Failure)...
April 2018: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29660306/ablation-of-toll-like-receptor-4-attenuates-aging-induced-myocardial-remodeling-and-contractile-dysfunction-through-ncori-hdac1-mediated-regulation-of-autophagy
#7
Shuyi Wang, Wei Ge, Carrie Harns, Xianzhong Meng, Yingmei Zhang, Jun Ren
Aging is usually accompanied with overt structural and functional changes as well as suppressed autophagy in the heart although the precise regulatory mechanisms are somewhat unknown. Here we evaluated the role of the innate proinflammatory mediator toll-like receptor 4 (TLR4) in cardiac aging and the underlying mechanism with a focus on autophagy. Cardiac geometry and function were monitored in young or old wild-type (WT) and TLR4 knockout (TLR4-/- ) mice using echocardiography, IonOptix® edge-detection and fura-2 techniques...
April 13, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29659790/ratio-of-transmitral-early-filling-velocity-to-early-diastolic-strain-rate-predicts-long-term-risk-of-cardiovascular-morbidity-and-mortality-in-the-general-population
#8
Mats Christian Højbjerg Lassen, Sofie Reumert Biering-Sørensen, Flemming Javier Olsen, Kristoffer Grundtvig Skaarup, Kirsten Tolstrup, Atif Nazier Qasim, Rasmus Møgelvang, Jan Skov Jensen, Tor Biering-Sørensen
Aims: It has previously been demonstrated that the ratio of early mitral inflow velocity to global diastolic strain rate (E/e'sr) is a significant predictor of cardiac events in specific patient populations. The utility of this measurement to predict cardiovascular events in a general population has not been evaluated. Methods and results: A total of 1238 participants in a general population study underwent a health examination including echocardiography where global longitudinal strain (GLS) and E/e'sr were determined...
April 5, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29659777/number-of-pregnancies-and-subsequent-phenotype-in-a-cross-sectional-cohort-of-women-with-arrhythmogenic-cardiomyopathy
#9
Anna I Castrini, Øyvind H Lie, Ida S Leren, Mette E Estensen, Mathis K Stokke, Lars G Klæboe, Thor Edvardsen, Kristina H Haugaa
Aims: We aimed to assess the relation between number of pregnancies and cardiac structure, function, and arrhythmic events in women with arrhythmogenic cardiomyopathy (AC). Methods and results: We included female AC patients in a cross-sectional study. Number of pregnancies and pregnancy related symptoms were recorded. Ventricular arrhythmias were defined as aborted cardiac arrest, sustained ventricular tachycardia, or appropriate implantable cardioverter-defibrillator therapy...
April 6, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29658867/repair-of-partial-anomalous-pulmonary-venous-connection-a-rare-case-evaluated-by-multi-slice-computed-tomographic-angiography
#10
Yukun Cao, Tin Yang, Ma Hou, Hongcha Zhang, Xi Chen, Fe Zou
Partial anomalous pulmonary venous connection (PAPVC) is an uncommon congenital heart disease, which may be difficult to identify and often remains undiagnosed. Accurate diagnosis of major aortopulmonary collaterals and partial anomalous pulmonary venous drainage in patients with congenital heart disease is important but problematic. The goal of this publication is to present the diagnosis and surgical repair of this rare pathology in an eight-year-old boy. Atrial septal defect was found by echocardiography, but no anomalous pulmonary vein was found...
March 8, 2018: Heart Surgery Forum
https://www.readbyqxmd.com/read/29657239/application-of-a-fresh-decellularized-pulmonary-allograft-for-pulmonary-valve-replacement-in-japan
#11
Hideto Ozawa, Takayoshi Ueno, Masaki Taira, Koichi Toda, Toru Kuratani, Yoshiki Sawa
BACKGROUND: Tissue engineering has advanced the technique of decellularization of the heart valve. The valve is reseeded with the patient's own cells after implantation with suppression of immunologic reactions. The same advantage has been reported for fresh decellularized heart valves, and more than 10 years of excellent outcomes have been achieved. We began performing such heart valve implantations in 2013 as part of a clinical study at Osaka University. We report our evaluation of the safety and efficacy of heart valve implantation...
April 14, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29657057/ventricular-efficiency-in-pregnant-women-with-congenital-heart-disease
#12
Jun Muneuchi, Keiko Yamasaki, Mamie Watanabe, Azusa Fukumitsu, Takeshi Kawakami, Hiromasa Nakahara, Kunitaka Joo
BACKGROUNDS: Pregnant women with congenital heart disease (CHD) are at risk of cardiovascular events during pregnancy as well as postpartum. The aim of our study is to address the feasibility of echocardiography-derived ventricular-arterial coupling during pregnancy and postpartum among women with CHD. METHODS: In 31 pregnant women with CHD, we performed serial echocardiography at the first and third trimesters, early and late postpartum. The indices of contractility (single-beat determined end-systolic elastance, Eesab ) and afterload (effective arterial elastance, Ea) were approximated on the basis of the systemic blood pressure and systemic ventricular volume...
June 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29657045/the-relationship-between-left-ventricular-structure-and-function-in-the-elite-rugby-football-league-athlete-as-determined-by-conventional-echocardiography-and-myocardial-strain-imaging
#13
Lynsey Forsythe, David Hunter MacIver, Christopher Johnson, Keith George, John Somauroo, Michael Papadakis, Benjamin Brown, Mohammad Qasem, David Oxborough
AIMS: The aims of this study were to establish the left ventricular (LV) phenotype in rugby football league (RFL) athletes and to mathematically model the association between LV size, strain (ɛ) and ejection fraction (EF). METHODS AND RESULTS: 139 male athletes underwent echocardiographic LV evaluation including ɛ imaging. Non-athletic males were used for comparison. All absolute and scaled structural indices were significantly larger (P < 0.05) in athletes with a predominance for normal LV geometry...
June 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29655822/clinical-spectrum-and-management-of-heart-failure-in-hypertrophic-cardiomyopathy
#14
REVIEW
Barry J Maron, Ethan J Rowin, James E Udelson, Martin S Maron
Heart failure (HF), characterized by excessive exertional dyspnea, is a common complication within the broad clinical spectrum of hypertrophic cardiomyopathy (HCM). HF has become an increasingly prominent management issue with the reduction in sudden deaths due to use of implantable defibrillators in this disease. Exertional dyspnea ranges in severity from mild to severe (New York Heart Association functional classes II to IV) and not uncommonly becomes refractory to medical management, leading to progressive disability, but largely in the absence of pulmonary congestion and volume overload requiring hospitalization...
April 5, 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/29655509/reduced-right-ventricular-fractional-area-change-strain-and-strain-rate-before-bidirectional-cavopulmonary-anastomosis-is-associated-with-medium-term-mortality-for-children-with-hypoplastic-left-heart-syndrome
#15
Lily Q Lin, Jennifer Conway, Silvia Alvarez, Benjamin Goot, Jesus Serrano-Lomelin, Timothy Colen, Edythe B Tham, Shelby Kutty, Ling Li, Nee Scze Khoo
BACKGROUND: Ventricular dysfunction is associated with increased morbidity and mortality in children with hypoplastic left heart syndrome. The aim of this study was to assess the diagnostic performance of conventional and speckle-tracking echocardiographic measures of right ventricular (RV) function before bidirectional cavopulmonary anastomosis palliation in predicting death or need for heart transplantation (HTx). METHODS: RV fractional area change (RVFAC) and longitudinal and circumferential strain and strain rate (SR) were measured in 64 prospectively recruited patients with hypoplastic left heart syndrome from echocardiograms obtained before bidirectional cavopulmonary anastomosis surgery...
April 12, 2018: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29653363/trapidil-improves-hemodynamic-echocardiographic-and-redox-state-parameters-of-right-ventricle-in-monocrotaline-induced-pulmonary-arterial-hypertension-model
#16
Patrick Türck, Denise Santos Lacerda, Cristina Campos Carraro, Bruna Gazzi de Lima-Seolin, Rayane Brinck Teixeira, Jéssica Hellen Poletto Bonetto, Rafael Colombo, Paulo Cavalheiro Schenkel, Adriane Belló-Klein, Alex Sander da Rosa Araujo
BACKGROUND: Pulmonary arterial hypertension is a disease characterized by increased pulmonary vascular resistance and redox imbalance, leading to failure of right ventricle. Trapidil has been described to improve the redox balance and cardiac conditions. HYPOTHESIS: Trapidil can improve the redox balance and contribute to functional improvements of the RV in PAH. METHODS AND RESULTS: Male, 5week-old Wistar rats were divided into four groups: Control, Control + Trapidil, Monocrotaline and Monocrotaline + Trapidil...
April 10, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29652651/prediction-of-organ-involvement-in-systemic-sclerosis-by-serum-biomarkers-and-peripheral-endothelial-function
#17
Shin-Ya Kawashiri, Ayako Nishino, Takashi Igawa, Ayuko Takatani, Toshimasa Shimizu, Masataka Umeda, Shoichi Fukui, Akitomo Okada, Takahisa Suzuki, Tomohiro Koga, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Munetoshi Nakashima, Akinari Mizokami, Naoki Matsuoka, Kiyoshi Migita, Fumihide Ogawa, Satoshi Ikeda, Koji Maemura, Hideki Nakamura, Tomoki Origuchi, Takahiro Maeda, Atsushi Kawakami
OBJECTIVES: To identify prognostic factors among serum biomarkers and endothelial vasodilator function findings in patients with systemic sclerosis (SSc). METHODS: This is a clinical observational study. We assessed 60 consecutive SSc patients (44 limited cutaneous-type, 16 diffuse cutaneous-type). Circulating growth differentiation factor-15 (GDF-15), placenta growth factor (PlGF), endostatin, vascular endothelial growth factor (VEGF), and pentraxin 3 (PTX3) were measured by ELISA...
April 12, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29652546/ataxia-telangiectasia-mutated-kinase-deficiency-impairs-autophagic-response-early-during-myocardial-infarction
#18
Patsy R Thrasher, Stephanie L C Scofield, Suman Dalal, Claire C Crawford, Mahipal Singh, Krishna Singh
Ataxia-telangiectasia mutated kinase (ATM) is activated in response to DNA damage. We have previously shown that ATM plays a critical role in myocyte apoptosis and cardiac remodeling following myocardial infarction (MI). Here, we tested the hypothesis that ATM deficiency results in autophagic impairment in the heart early during MI. MI was induced in wild-type (WT) and ATM heterozygous knockout (hKO) mice by ligation of the left anterior descending artery (LAD). Structural and biochemical parameters of the heart were measured 4 hours following LAD ligation...
April 13, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29651618/effect-of-renal-sympathetic-denervation-on-ventricular-and-neural-remodeling
#19
L Wang, G Wei, L Song, C Li, F Zhang, Y Yang, C Lu
BACKGROUND: This study assessed the therapeutic effects of renal sympathetic denervation (RDN) on post-myocardial infarction (MI) ventricular remodeling and sympathetic neural remodeling in dogs. The possible mechanisms and optimal time for treatment are discussed. METHODS: We randomly assigned 30 dogs to five groups: RDN 1 week before MI (RDN1w + MI; n = 6), RDN 1 week after MI (MI1w + RDN; n = 6), RDN 2 weeks after MI (MI2w + RDN; n = 6), control (N; n = 6), and MI (n = 6)...
April 12, 2018: Herz
https://www.readbyqxmd.com/read/29651605/diagnostic-role-of-strain-imaging-in-atypical-myocarditis-by-echocardiography-and-cardiac-mri
#20
Bethany L Wisotzkey, Brian D Soriano, Erin L Albers, Mark Ferguson, Sujatha Buddhe
BACKGROUND: The diagnosis of myocarditis presenting as isolated acute chest pain with elevated troponins but normal systolic function is challenging with significant drawbacks even for the gold-standard endomyocardial biopsy. OBJECTIVE: This study aimed to evaluate the diagnostic role of strain imaging by echocardiography and cardiac MRI in these patients. MATERIALS AND METHODS: This was a retrospective review of children with cardiac MRI for acute chest pain with elevated troponins compared to normal controls...
April 13, 2018: Pediatric Radiology
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