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Functional echocardiography

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https://www.readbyqxmd.com/read/29222864/effects-of-cardiac-resynchronization-therapy-after-inferior-myocardial-infarction-on-secondary-mitral-regurgitation-and-mitral-valve-geometry
#1
Christos G Mihos, Evin Yucel, Romain Capoulade, Mary P Orencole, Gaurav A Upadhyay, Orlando Santana, Jagmeet P Singh, Michael H Picard
BACKGROUND: The effects of cardiac resynchronization therapy (CRT) on secondary mitral regurgitation (MR), and mitral valve (MV) and left ventricular (LV) geometry, in patients with prior inferior myocardial infarction is not clearly defined. We assessed these outcomes utilizing 2-dimensional echocardiography, and analyzed echocardiographic geometric variables that may correlate with follow-up MR severity. METHODS: Between 2009 and 2012, 229 CRT were implanted. Twenty-two had prior inferior myocardial infarction, ≥ mild MR at baseline, and serial echocardiography...
December 9, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29222822/coronary-microvascular-dysfunction-and-myocardial-contractile-reserve-in-women-with-angina-and-no-obstructive-coronary-artery-disease
#2
Marie M Michelsen, Adam Pena, Naja D Mygind, Jan Bech, Ida Gustafsson, Jens Kastrup, Henrik S Hansen, Nis Høst, Peter R Hansen, Eva Prescott
BACKGROUND: Coronary microvascular dysfunction (CMD) is a potential cause of myocardial ischemia and may affect myocardial function at rest and during stress. We investigated whether CMD was associated with left ventricular diastolic and systolic function at rest and during pharmacologically induced hyperemic stress. METHODS: In a prospective cohort study, we included 963 women with angina, left ventricular ejection fraction (LVEF) >45%, and an invasive coronary angiogram without significant stenosis (<50%)...
December 8, 2017: Echocardiography
https://www.readbyqxmd.com/read/29221138/gas-signaling-molecule-hydrogen-sulfide-attenuates-doxorubicin-induced-dilated-cardiomyopathy
#3
Zongliang Yu, Wei Zhang, Mengyao Zhang, Mengchao Jin, Weiting Xu, Xiang Zhou
Increasing evidence has revealed that hydrogen sulfide (H2S) has beneficial effects in the treatment of various cardiovascular diseases. However, whether H2S can attenuate the development of dilated cardiomyopathy (DCM) remains unclear. In this study, we generated a rat model of DCM induced by doxorubicin and investigated the protective effects of H2S against DCM. Cardiac structure and function were analyzed by two-dimensional echocardiography. Oxidative stress was evaluated by measuring malondialdehyde, superoxide dismutase, glutathione peroxidase and reactive oxygen species...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29218015/trimethylamine-n-oxide-supplementation-abolishes-the-cardioprotective-effects-of-voluntary-exercise-in-mice-fed-a-western-diet
#4
Hongqi Zhang, Jian Meng, Haiyan Yu
Excessive consumption of western diet (WD) induces obesity, resulting in cardiac dysfunction. Voluntary exercise ameliorates WD-induced obesity, but its effect on cardiac dysfunction remains unclear. Recent evidence suggests that elevated trimethylamine N-oxide (TMAO), a gut microbe-derived metabolite, can impair cardiac function in WD-induced obesity. We hypothesized that cardiac dysfunction in WD-induced obesity would be prevented by voluntary exercise but abolished by TMAO supplementation. Male CD1 mice fed a WD were assigned to sedentary, exercise or exercise with TMAO treatment for 8 weeks...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29218014/acute-effects-of-positive-airway-pressure-on-functional-mitral-regurgitation-in-patients-with-systolic-heart-failure
#5
Takao Kato, Takatoshi Kasai, Shoichiro Yatsu, Azusa Murata, Hiroki Matsumoto, Shoko Suda, Masaru Hiki, Nanako Shiroshita, Mitsue Kato, Fusae Kawana, Sakiko Miyazaki, Hiroyuki Daida
Background: Acute effects of positive airway pressure (PAP) [including continuous PAP (CPAP) and adaptive servo-ventilation, an advanced form of bi-level PAP] on functional mitral regurgitation (fMR) in patients with heart failure (HF) with left ventricular (LV) systolic dysfunction remain unclear. Thus, whether PAP therapy reduces fMR in such patients with HF was investigated. Methods and Results: Twenty patients with HF and LV systolic dysfunction defined as LV ejection fraction (LVEF) <50% (14 men; mean LVEF, 35...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29217244/intraoperative-transesophageal-and-postoperative-transthoracic-echocardiographic-evaluation-of-a-mechanical-heart-valve-prosthesis-implanted-at-aortic-position
#6
Saravana Babu, Rupa Sreedhar, Shrinivas V Gadhinglajkar, Prasanta Kumar Dash, Subin Sukesan, Vivek Pillai, Varghese T Panicker, Lovhale Pravin Shriram, Neelam Aggarwal
OBJECTIVE: The aims of this study were to evaluate the intraoperative transesophageal echocardiographic (iTEE) characteristics and Doppler flow profile of aortic Chitra heart valve prosthesis (CHVP) under stable hemodynamic and loading conditions, and to compare and correlate the iTEE data with the postoperative transthoracic echocardiography (TTE) data obtained at 48 hours (TTE1) and 3 months (TTE2) after the surgery. DESIGN: Prospective, observational study. SETTING: University-level tertiary referral hospital...
September 6, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29216977/noninvasive-cardiac-imaging-and-the-prediction-of-heart-failure-progression-in%C3%A2-preclinical-stage-a-b-subjects
#7
REVIEW
Fei Fei Gong, Duncan J Campbell, David L Prior
Heart failure (HF) continues to grow as a cause of morbidity and mortality in our community and presents a significant public health problem, predominantly in individuals ≥65 years of age. Early intervention in asymptomatic HF subjects (Stage A/B) at risk of progression to symptomatic HF (Stage C/D) may provide an opportunity to halt this epidemic. The ability of cardiac imaging to assess cardiac structure and function permits early identification of those at increased risk of developing symptomatic HF. Systolic, diastolic, and structural left ventricular parameters each predict symptomatic HF, but no single parameter has sufficient sensitivity for screening to identify individuals with Stage A/B HF who are at increased risk of disease progression...
December 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29216794/fragmented-qrs-complexes-are-associated-with-left-ventricular-dysfunction-in-patients-with-type-2-diabetes-mellitus-a-two-dimensional-speckle-tracking-echocardiography-study
#8
Adil Bayramoğlu, Hakan Taşolar, Yasemin Kaya, Osman Bektaş, Ahmet Kaya, Mehmet Yaman, Zeki Yüksel Günaydın
BACKGROUND: Heart failure may develop independently of coronary artery disease in diabetes mellitus (DM) patients. Fragmented QRS (fQRS) is a marker of myocardial fibrosis or scar tissue and is related to an increase in cardiovascular adverse events. In this study, we examined the utility of speckle tracking echocardiography (STE) in assessing LV function in DM patients with fQRS. METHODS AND RESULTS: The current study included 178 consecutive patients diagnosed with type-2 DM...
December 7, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/29216197/shift-toward-greater-pathologic-post-myocardial-infarction-remodeling-with-loss-of-the-adaptive-hypertrophic-signaling-of-alpha1-adrenergic-receptors-in-mice
#9
Che-Chung Yeh, Yanying Fan, Yanchun Xu, Yi-Lin Yang, Paul C Simpson, Michael J Mann
RATIONALE: We have hypothesized that post-infarction cardiac remodeling can be influenced by shifts in the balance between intracellular mediators of "pathologic" and "physiologic" hypertrophy. Although alpha1 adrenergic receptors (alpha1-ARs) mediate pro-adaptive hypertrophy during pressure overload, little is known about their role or downstream mediators after myocardial infarction. METHODS: We performed loss-of-function experiments via coronary ligation in alpha1A-AR knockout (AKO) mice...
2017: PloS One
https://www.readbyqxmd.com/read/29214833/living-with-functionally-univentricular-heart-beating-the-odds
#10
Safak Alpat, Metin Demircin
An unoperated 45-year-old man with double-inlet single left ventricle, transposed great arteries, ventricular septal defect, and pulmonary stenosis presented with mitral and pulmonary valvular vegetations unresponsive to antibiotic therapy. The initial diagnosis was made with echocardiography, and the morphology was delineated with computed tomography and magnetic resonance imaging. The patient underwent mitral valve replacement with a mechanical valve and pulmonary valve vegetectomy. He recovered well and he is currently well two years after the operation...
January 1, 2017: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/29214787/myocardial-layer-specific-strain-analysis-in-children-with-mitochondrial-disease
#11
Lucy Youngmin Eun, Young Mock Lee
PURPOSE: Children with mitochondrial disease (MD) have clinical phenotypes that are more severe than those found in adults. In this study, we assessed cardiac function in children with MD using conventional and advanced echocardiographic measurements, explored any unique patterns present, and investigated the development of early cardiomyopathy (CMP). MATERIALS AND METHODS: We retrospectively reviewed the medical records of 33 children with MD. All patients underwent transthoracic echocardiography with conventional and advanced myocardial analysis...
January 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29214686/myricetin-attenuated-lps-induced-cardiac-injury-in-vivo-and-in-vitro
#12
Nan Zhang, Hong Feng, Hai-Han Liao, Si Chen, Zheng Yang, Wei Deng, Qi-Zhu Tang
Sepsis induced myocardial dysfunction (SIMD) is a common complication and leads to an increased mortality. SIMD is closely related to inflammation and oxidative stress. Myricetin exhibits strong capacities of anti-inflammation and anti-oxidative stress, but its pharmacological effects for lipopolysaccharide (LPS) induced cardiac injury remains undefined. This study aimed to explore whether myricetin was efficient to alleviate SIMD in mice and neonatal rat cardiomyocytes injury. Mice administrated with myricetin (100 mg/kg, po, bid) or vehicle groups were challenged with LPS (10 mg/kg, ip), and cardiac functions examined by echocardiography after 12 hr LPS exposure...
December 7, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29214659/2d-speckle-tracking-echocardiography-of-the-right-ventricle-free-wall-in-scuba-divers-after-single-open-sea-dive
#13
Zora Susilovic-Grabovac, Ante Obad, Darko Duplančić, Ivana Banić, Denise Brusoni, Piergiuseppe Agostoni, Ivica Vuković, Zeljko Dujic, Darija Bakovic
The presence of circulating gas bubbles and their influence on pulmonary and right heart hemodynamics was reported after uncomplicated self-contained underwater breathing apparatus (SCUBA) dive(s). Improvements in cardiac imaging have recently focused great attention on the right ventricle (RV). The aim of our study was to evaluate possible effects of a single air SCUBA dive on RV function using 2D speckle tracking echocardiography in healthy divers after single open sea dive to 18 meters of seawater, followed by bottom stay of 47 minutes with a direct ascent to the surface...
December 7, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29212963/association-between-elevated-echocardiographic-index-of-left-ventricular-filling-pressure-and-acute-kidney-injury-after-off-pump-coronary-artery-surgery
#14
Min Hur, Karam Nam, Woo Young Jo, Gahyun Kim, Won Ho Kim, Jae-Hyon Bahk
BACKGROUND: The ratio of the early transmitral flow velocity to early diastolic velocity of the mitral annulus (E/e') is an echocardiographic index of mean left ventricular (LV) filling pressure. We investigated the association between the preoperative E/e' ratio and postoperative acute kidney injury (AKI) during off-pump coronary artery bypass surgery (OPCAB).Methods and Results:We reviewed 585 patients who underwent OPCAB and with preserved LV ejection fraction determined by preoperative echocardiography...
December 5, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29212899/novel-mutation-in-flnc-filamin-c-causes-familial-restrictive-cardiomyopathy
#15
Nathan R Tucker, Micheal A McLellan, Dongjian Hu, Jiangchuan Ye, Victoria A Parsons, Robert W Mills, Sebastian Clauss, Elena Dolmatova, Marisa A Shea, David J Milan, Nandita S Scott, Mark Lindsay, Steven A Lubitz, Ibrahim J Domian, James R Stone, Honghuang Lin, Patrick T Ellinor
BACKGROUND: Restrictive cardiomyopathy (RCM) is a rare cardiomyopathy characterized by impaired diastolic ventricular function resulting in a poor clinical prognosis. Rarely, heritable forms of RCM have been reported, and mutations underlying RCM have been identified in genes that govern the contractile function of the cardiomyocytes. METHODS AND RESULTS: We evaluated 8 family members across 4 generations by history, physical examination, electrocardiography, and echocardiography...
December 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/29212353/psoriasis-and-cardiovascular-risk-correlation-between-psoriasis-and-cardiovascular-functional-indices
#16
Giuseppe Dattilo, Egidio Imbalzano, Matteo Casale, Claudio Guarneri, Francesco Borgia, Stefania Mondello, Pasqualina Laganà, Pietro Romano, Giuseppe Oreto, Sarafinella Cannavò
Evidence suggests that psoriasis together with other cardiovascular (CV) risk factors is associated with increased vascular morbidity, but it is not clear whether psoriasis is an independent risk factor. Consecutive patients (n = 33; 35.6 ± 5.7 years; 13 females) with mild psoriasis (Psoriasis Area and Severity Index <10) without comorbidities and 33 healthy participants (36.3 ± 5.9 years; 15 females) were enrolled. Both groups underwent echocardiography, speckle tracking (2-dimensional strain echocardiography [2D-SE]), and pulse wave velocity (PWV) testing...
January 2018: Angiology
https://www.readbyqxmd.com/read/29212219/microrna-126a-5p-enhances-myocardial-ischemia-reperfusion-injury-through-suppressing-hspb8-expression
#17
Bimei Jiang, Yanjuan Liu, Pengfei Liang, Yuanbin Li, Zhenguo Liu, Zhongyi Tong, Qinglan Lv, Meidong Liu, Xianzhong Xiao
Previously, we found several genes are involved in myocardial ischemia-reperfusion (M-I/R) injury. In this report, we first developed a mouse model of M-I/R injury and demonstrated microRNA-126a-5p was associated with the M-I/R injury by using high-throughput microRNA expression analysis. We further investigated the expression and function of microRNA-126a-5p during mouse M-I/R injury. We observed high expression of microRNA-126a-5p in the M-I/R mice and increased levels of LDH and CK-MB (damage markers) in the serum...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29210202/amount-or-intensity-potential-targets-of-exercise-interventions-in-patients-with-heart-failure-with-preserved-ejection-fraction
#18
Anna Bobenko, Inke Bartels, Marlene Münch, Tobias Trippel, Ruhdja Lindhorst, Kathleen Nolte, Christoph Herrmann-Lingen, Martin Halle, André Duvinage, Hans-Dirk Düngen, Götz Gelbrich, Carsten Tschöpe, Gerd Hasenfuss, Rolf Wachter, Burkert Pieske, Frank Edelmann
AIMS: Heart failure with preserved ejection fraction (HFpEF) remains a common condition with no pharmacological treatment. Physical activity (PA) improves symptoms and quality of life (QoL), but no clear recommendations exist on PA in HFpEF patients. We investigated the association of PA (amount/intensity) on clinical phenotype in HFpEF. METHODS AND RESULTS: The Aldosterone in Diastolic Heart Failure trial investigated spironolactone vs. placebo in stable HFpEF patients...
December 6, 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/29210085/subclinical-systolic-and-diastolic-dysfunctions-in-patients-with-metabolic-syndrome-and-angiographically-normal-coronary-arteries-an-echocardiographic-study
#19
Niloufar Samiei, Maryam Bayat, Ata Firouzi, Faezeh Dehghani, Mozhgan Parsaee, Shahin Rahimi, Somayyeh Ahmadi, Maryam Pourmojib, Zahra Ghaemmaghami, Yousef Rezaei, Mohammad Mehdi Peighambari
BACKGROUND: The metabolic syndrome (MetS), as a combination of cardiovascular risk factors, is associated with subclinical cardiovascular diseases. We sought to evaluate the subclinical myocardial dysfunctions using echocardiography in patients with normal coronary arteries. MATERIALS AND METHODS: In this cross-sectional study, we assessed 50 consecutive patients with angiographically-proven normal coronary arteries and a left ventricular (LV) ejection fraction (EF) ≥55%...
December 6, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/29208858/correlation-of-troponin-i-level-with-left-ventricular-ejection-fraction-and-in-hospital-outcomes-after-first-attack-of-non-st-segment-elevation-myocardial-infarction
#20
M H Khan, M N Islam, G P Aditya, M Z Islam, A S Bhuiyan, B Saha, K Bhowmick, M Hassan, P K Paul, S Chowdhury, R Rahman
Coronary heart disease (CHD) is the most common cause of heart disease and is the single most important cause of premature death in developed world. Recognizing a patient with ACS is important because the diagnosis triggers both triage and management. cTnI is 100% tissue-specific for the myocardium and it has been shown to be a very sensitive and specific marker for acute myocardial infarction (AMI). Ventricular function is the best predictor of death after an acute coronary syndrome. It serves as a marker of myocardial damage, provides information on systolic function as well as diagnosis and prognosis...
October 2017: Mymensingh Medical Journal: MMJ
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