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https://www.readbyqxmd.com/read/28109079/silencing-of-ribosomal-protein-l34-rpl34-inhibits-the-proliferation-and-invasion-of-esophageal-cancer-cells
#1
Huijie Fan, Jing Li, Yongxu Jia, Jingjing Wu, Long Yuan, Mingjun Li, Jiangqi Wei, Benling Xu
Ribosomal protein L34 (RPL34) belongs to the L34E family of ribosomal proteins and contains a zinc finger motif. Aberrant expression of RPL34 has been reported in several human malignancies. However, the precise role and potential underlying mechanisms of RPL34 in human esophageal cancer remain largely unknown. Thus, the objective of this study was to investigate the role of RPL34 in esophageal cancer progression. Our results showed that the expression of RPL34 at both mRNA and protein levels was frequently up-regulated in esophageal cancer cell lines...
January 20, 2017: Oncology Research
https://www.readbyqxmd.com/read/28108950/t-cell-receptor-engineered-t-cells-for-cancer-treatment-current-status-and-future-directions
#2
REVIEW
Yu Ping, Chaojun Liu, Yi Zhang
T-cell receptor (TCR)-engineered T cells are a novel option for adoptive cell therapy used for the treatment of several advanced forms of cancer. Work using TCR-engineered T cells began more than two decades ago, with numerous preclinical studies showing that such cells could mediate tumor lysis and eradication. The success of these trials provided the foundation for clinical trials, including recent clinical successes using TCR-engineered T cells to target New York esophageal squamous cell carcinoma (NY-ESO-1)...
January 20, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28108314/mirna-638-promotes-autophagy-and-malignant-phenotypes-of-cancer-cells-via-directly-suppressing-dact3
#3
Yanli Ren, Yujie Chen, Xue Liang, Yan Lu, Wenting Pan, Ming Yang
Dyregulation of autophagy is implicated in human cancers and the mechanism details remains largely unclear. Herein we report the regulatory role of miR-638 in autophagy of esophageal squamous cell carcinoma (ESCC) and breast cancer cells. We found that miR-638 overexpression promotes starvation- and rapamycin-induced autophagy. In ESCC and breast cancer cells, miR-638 acts as an oncogene and promote cell proliferation, migration, as well as invasion in vitro and in vivo. In accordance with this, we observed significantly higher miR-638 expression in ESCC and breast cancer tissues compared to normal tissues...
January 17, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28107467/correction-routine-endoscopy-for-esophageal-cancer-is-suggestive-for-patients-with-oral-oropharyngeal-and-hypopharyngeal-cancer
#4
Shih-Han Hung, Ming-Chieh Tsai, Tsai-Ching Liu, Herng-Ching Lin, Shiu-Dong Chung
[This corrects the article DOI: 10.1371/journal.pone.0072097.].
2017: PloS One
https://www.readbyqxmd.com/read/28106227/can-ngal-be-employed-as-prognostic-and-diagnostic-biomarker-in-human-cancers-a-systematic-review-of-current-evidence
#5
Laura Roli, Valentina Pecoraro, Tommaso Trenti
BACKGROUND: Some studies have reported differentially altered neutrophil gelatinase-associated lipocalin (NGAL) levels in several malignancies. We evaluated NGAL measured in plasma or urine as both prognostic and diagnostic marker for different types of human tumors. METHODS: We performed systematic electronic searches in Medline, Embase and CRDTAS. Studies were included if they evaluated NGAL as a prognostic or diagnostic marker for human cancers. The selection of the studies, screening of the full texts and data extraction were conducted independently by 2 authors...
January 16, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28105355/evaluation-of-prognostic-markers-for-patients-with-curatively-resected-thoracic-esophageal-squamous-cell-carcinomas
#6
Masahide Ikeguchi, Yusuke Kouno, Kyoichi Kihara, Kazunori Suzuki, Kanenori Endo, Seiichi Nakamura, Takashi Sawada, Tetsu Shimizu, Tomoyuki Matsunaga, Yoji Fukumoto, Hiroaki Saito
The Glasgow Prognostic Score (GPS), neutrophil/lymphocyte ratio (NLR) and prognostic nutritional index (PNI) are prognostic parameters for malignancies. Additionally, serum squamous cell carcinoma antigen (SCC-Ag) and cytokeratin 19 fragments (CYFRA 21-1) are tumor markers for squamous cell carcinoma. In the present study, the prognostic importance of these markers in patients with resectable thoracic esophageal cancer was investigated. In this retrospective study, 84 enrolled patients diagnosed with resectable clinical stage I-III thoracic esophageal squamous cell carcinomas (ESCCs) underwent thoracic esophageal resection and three-field lymph node dissection at Tottori University Hospital between January 2007 and December 2013...
December 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28105341/changes-in-blood-concentrations-of-trace-metals-in-cancer-patients-receiving-cisplatin-based-chemotherapy
#7
Tsutomu Nakamura, Minoru Takahashi, Riho Niigata, Kazuhiko Yamashita, Manabu Kume, Midori Hirai, Hiroyuki Yasui
The administration of cisplatin (CDDP) may influence trace metal concentrations in body fluids. In order to test this hypothesis, the blood concentrations of trace metals were determined during the present study in eight Japanese esophageal and lung cancer patients receiving CDDP-based chemotherapy. The levels of manganese, iron (Fe), cobalt, copper, zinc (Zn), platinum and lead in the plasma were determined by inductively coupled plasma-mass spectrometry. In addition, the serum levels of Fe, transferrin and ferritin were evaluated...
December 2016: Biomedical Reports
https://www.readbyqxmd.com/read/28105186/upregulated-mir-193a-3p-as-an-oncogene-in-esophageal-squamous-cell-carcinoma-regulating-cellular-proliferation-migration-and-apoptosis
#8
Yunfeng Yi, Jianming Chen, Changjie Jiao, Jing Zhong, Zhiming Song, Xiaoping Yu, Xiujuan Lu, Baoli Lin
MicroRNAs (miRs) are small endogenous non-coding RNAs that play a vital role in carcinogenesis. miR-193a-3p has been described in multiple cancers. However, the function of miR-193a-3p in esophageal squamous cell carcinoma (ESCC) is still unclear. To explore the role of miR-193a-3p in ESCC, reverse transcription-quantitative polymerase chain reaction was used to evaluate the expression of miR-193a-3p in 48 paired ESCC and adjacent normal tissues. In addition, the impact of miR-193a-3p on cell proliferation, migration and apoptosis were analyzed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, wound scratch assay and flow cytometry, respectively...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28105174/improved-sensitization-effect-of-sunitinib-in-cancer-cells-of-the-esophagus-under-hypoxic-microenviroment
#9
Yu-Qiong Ding, Qin Qin, Yan Yang, Xin-Chen Sun, Xi Yang, Hong-Cheng Zhu, Xiao-Chen Chen, Hao Zhang, Yue-Hua Yang, Lei Gao, Ju-Dong Luo, Xi-Fa Zhou
Radiotherapy is widely used in esophageal squamous cell carcinoma (ESCC) treatment. Promoting the radiation sensitivity of cancer cells is required. Recent studies have shown that sunitinib can inhibit the growth of several cancer lines. However, few studies on the radiosensitive effect of sunitinib on ESCC cells under hypoxic conditions have been conducted. In the present study, the radiosensitive effects of sunitinib on human ESCC cells were assessed, and the underlying mechanisms were explored. ESCC cells were exposed to hypoxia and treated with sunitinib at different concentrations prior to irradiation...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28104797/not-all-esophageal-tumors-equal
#10
(no author information available yet)
Although squamous cell carcinomas and adenocarcinomas of the esophagus differ histologically, they are often lumped together in clinical trials. Genomic analysis shows that the two cancers are molecularly distinct. Esophageal adenocarcinomas are more similar to stomach adenocarcinomas, whereas esophageal squamous cell carcinomas are closer to head and neck squamous cell carcinomas.
January 19, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28104467/incidence-and-risk-factors-of-acute-kidney-injury-after-esophageal-cancer-surgery-a-nested-case-control-study
#11
Wen Wang, Tong Wang, Xiaoshuang Feng, Li Sun
BACKGROUND: Acute kidney injury (AKI) has been increasingly recognized as a common and serious postoperative complication. Although many studies have been conducted to investigate postoperative AKI after thoracic surgery, little is known about AKI after esophageal surgery. Thus, we conducted this study to determine the incidence and identify risk factors of postoperative AKI after esophageal cancer surgery. MATERIALS AND METHODS: A retrospective nested case-control study of patients undergoing elective esophageal cancer surgery between July 2013 and July 2016 in a single tertiary specialized cancer hospital was performed...
January 16, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28104297/brachytherapy-for-the-palliation-of-dysphagia-owing-to-esophageal-cancer-a-systematic-review-and-meta-analysis-of-prospective-studies
#12
Lorenzo Fuccio, Daniele Mandolesi, Andrea Farioli, Cesare Hassan, Leonardo Frazzoni, Alessandra Guido, Nicola de Bortoli, Savino Cilla, Chiara Pierantoni, Francesco Saverio Violante, Franco Bazzoli, Alessandro Repici, Alessio Giuseppe Morganti
BACKGROUND: The management of dysphagia owing to esophageal cancer is challenging. Brachytherapy has been proposed as an alternative option to stent placement. We performed a systematic review to examine its efficacy and safety in the resolution of dysphagia. METHODS: Prospective studies recruiting at least 20 patients with malignant dysphagia and published up to April 2016 were eligible. The dysphagia-free survival (DFS) and adverse event rates were pooled by means of a random effect model...
January 16, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28104037/-efficacy-of-esophageal-cancer-screening-in-high-risk-population-results-of-105-561-subjects-in-sichuan-province
#13
X Wang, B Li, Y Bao, Y Wang, A R Wang, L Qiao
Objective: To analyze the efficacy of endoscopic screening for esophageal cancer in high risk population from high risk areas in order to provide scientific basis for evaluation of the results of early diagnosis and treatment of esophageal cancer. Methods: Ten high incidence cities and counties of esophageal cancer in Sichuan province were included in this study. Subjects aged 40-69 years were selected to participate in the endoscopic screening based on the cluster sampling, and the screening-positive subjects were further confirmed by pathological examination...
January 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28104036/-analysis-of-cancer-incidence-and-mortality-in-elderly-population-in-china-2013
#14
W Q Chen, R S Zheng, S W Zhang, H M Zeng, X N Zou, J He
Objective: To estimate the cancer incidence and mortality in elderly Chinese population in 2013 based on the data from local cancer registries submitted to National Central Cancer Registry (NCCR). Methods: Data from 255 cancer registries submitted to NCCR with qualified data after checked and evaluated, were selected for this estimation. Cancer incidence and mortality were stratified by areas, sex, age groups and cancer site, combined with population data of the year 2013 to estimate cancer epidemiology in older people in China...
January 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28103974/-phase-i-study-of-etoposide-and-cisplatin-chemotherapy-dose-escalation-%C3%A2-with-concurrent-twice-daily-radiotherapy-for-patients-%C3%A2-with-limited-stage-small-cell-lung-cancer
#15
Jing You, Huiming Yu, Maxiaowei Song, Chen Shi, Xiaohang Wang, Ye Zheng, Rong Yu, Anhui Shi, Guangying Zhu
BACKGROUND: Concurrent twice-daily radiotherapy with chemotherapy of EP regimen is one of the current standard treatments for limited-stage small cell lung cancer. However, the safely tolerated dose of standard chemotherapy for Chinese patients is not decided. This study was to evaluate the toxicity and the maximum tolerated dose (MTD) of etoposide and cisplatin concurrent with thoracic radiation therapy for patients with limited-stage small cell lung cancer. METHODS: Patients with histologically proven limited-stage small cell lung cancer (LS-SCLC) were eligible...
January 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/28103970/-a-phase-i-ii-study-of-chemotherapy-concurrent-with-twice-daily-radiotherapy-%C3%A2-schedules-by-intensity-modulated-radiation-therapy-using-simultaneous-integrated-boost-for-limited-stage-small-cell-lung-cancer
#16
Jing You, Huiming Yu, Maxiaowei Song, Chen Shi, Xiaohang Wang, Ye Zheng, Rong Yu, Anhui Shi, Guangying Zhu
BACKGROUND: Twice-daily radiation concurrent with chemotherapy is one of the standard methods for limited-stage small cell lung cancer. The study was to evaluate the feasibility of chemotherapy concurrent with dose-escalating twice-daily radiotherapy by simultaneous integrated boost intensity-modulated radiation therapy (SIB-IMRT) approach in patients with limited-stage small cell lung cancer. METHODS: Patients with limited-stage small cell lung cancer were included, treated with twice-daily radiotherapy by SIB-IMRT concurrent with chemotherapy of etoposide plus cisplatin...
January 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/28103919/prognostic-values-of-apoptosis-stimulating-p53-binding-protein-1-and-2-and-their-relationships-with-clinical-characteristics-of-esophageal-squamous-cell-carcinoma-patients-a-retrospective-study
#17
Xiao-Feng Xie, Qing Yang, Jun Chi, Xian-Zi Yang, Hui-Yun Wang, Guo-Liang Xu
BACKGROUND: Esophageal squamous cell carcinoma (ESCC) is a leading cause of cancer-related death, and new prognostic biomarkers are urgently needed. Apoptosis-stimulating P53-binding protein 1 (ASPP1) and 2 (ASPP2) have been reported to play important roles in the development, progression, metastasis, and prognosis of cancers, but their roles in ESCC have not been elucidated. In this study, we examined the expression of ASPP1 and ASPP2 in ESCC to evaluate their prognostic values. METHODS: The protein expression of ASPP1, ASPP2, and P53 in 175 specimens of ESCC was detected using immunohistochemical staining; their expression in cancerous and noncancerous tissues was scored according to the staining intensity and the percentage of stained cells...
January 19, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28103517/a-noninvasive-cancer-detection-strategy-based-on-gold-nanoparticle-surface-enhanced-raman-spectroscopy-of-urinary-modified-nucleosides-isolated-by-affinity-chromatography
#18
Shangyuan Feng, Zuci Zheng, Yuanji Xu, Jinyong Lin, Guannan Chen, Cuncheng Weng, Duo Lin, Sufang Qiu, Min Cheng, Zufang Huang, Lan Wang, Rong Chen, Shusen Xie, Haishan Zeng
The search for tumor biomarkers in the urine for cancer diagnosis is currently a hot topic in clinical oncology, with potential for cancer screening and diagnosis. Modified nucleosides excreted through the urine are considered to be a general tumor marker for various cancer types. Herein, we explore a new method that utilizes surface-enhanced Raman scattering (SERS) spectroscopy to obtain a complete biochemical profile of urinary modified nucleosides. In our method, modified nucleosides are first isolated from urine sample utilizing the excellent separation ability of affinity chromatography; then supplemented with gold (Au) nanoparticles as substrate for SERS spectroscopy analysis...
January 5, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28103500/thoracoscopic-surgery-in-the-prone-position-for-esophageal-cancer-in-patients-with-situs-inversus-totalis-a-report-of-two-cases
#19
Toru Nakano, Takashi Kamei, Yu Onodera, Naoto Ujiie, Noriaki Ohuchi
INTRODUCTION: Situs inversus totalis (SIT) is a rare congenital condition characterized by a complete transposition of thoracic and abdominal organs. Here, we present two successful cases of left thoracoscopic esophagectomy in the prone position for SIT-associated esophageal cancer. PRESENTATION OF CASE: Our first case was of an 82-year-old man who underwent a left thoracoscopic esophagectomy in the prone position, followed by hand-assisted laparoscopic gastric mobilization...
January 6, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28100387/-economic-burden-of-esophageal-cancer-in-china-from-1996-to-2015-a-systematic-review
#20
L W Guo, C L Shi, H Y Huang, L Wang, X P Yue, S Z Liu, J Li, K Su, M Dai, X B Sun, J F Shi
Objective: To explore existing evidence of economic burden of esophageal cancer in China over the past 20 years. Methods: Based on PubMed, CNKI and Wanfang, literatures published from 1996 to 2015 were retrieved with the key words such as " economic burden" , "cost of illness" and so on. Then the information excerpted from those literatures were analyzed after several exclusionary procedures for non-esophageal cancer related literatures. The information about subjects and data source, methodology, main results were structurally abstracted and then analyzed...
January 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
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