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Diogo F M Santos, Olívia S G P Soares, José L Figueiredo, Manuel Fernando R Pereira
Cryptomelane-type manganese oxides prepared by a solvent-free method were evaluated as catalysts for the oxidation of ethyl acetate, ethanol and toluene. The original catalyst (K-OMS-2) presented high catalytic activity for ethyl acetate and ethanol oxidation, achieving 90% conversion into CO2 around 200 °C for both pollutants. Toluene was much harder to oxidize, requiring a temperature near 270 °C for the same conversion. The original catalyst was mechanically treated in a ball mill at different intensities, in order to decrease the particle size for subsequent impregnation onto structured supports, as small particle sizes are usually recommended...
June 20, 2018: Environmental Technology
B W P Reeve, S M McFall, R Song, R Warren, K R Steingart, G Theron
SETTING: Eliminating tuberculosis in high-burden settings requires improved diagnostic capacity. Important tests such as Xpert® MTB/RIF and culture are often performed at centralised laboratories that are geographically distant from the point of specimen collection. Preserving specimen integrity during transportation, which could affect test performance, is challenging. OBJECTIVE: To conduct a systematic review of commercial products for specimen preservation for a World Health Organization technical consultation...
July 1, 2018: International Journal of Tuberculosis and Lung Disease
Jennifer L Moore, Kirsten Potter, Kathleen Blankshain, Sandra L Kaplan, Linda C OʼDwyer, Jane E Sullivan
BACKGROUND: Use of outcome measures (OMs) in adult neurologic physical therapy is essential for monitoring changes in a patient's status over time, quantifying observations and patient-reported function, enhancing communication, and increasing the efficiency of patient care. OMs also provide a mechanism to compare patient and organizational outcomes, examine intervention effectiveness, and generate new knowledge. This clinical practice guideline (CPG) examined the literature related to OMs of balance, gait, transfers, and patient-stated goals to identify a core set of OMs for use across adults with neurologic conditions and practice settings...
June 12, 2018: Journal of Neurologic Physical Therapy: JNPT
Laura Mori, Valeria Prada, Alessio Signori, Davide Pareyson, Giuseppe Piscosquito, Luca Padua, Costanza Pazzaglia, Gian M Fabrizi, Alessandro Picelli, Angelo Schenone
BACKGROUND: The outcome measures (OMs) in clinical trials for Charcot Marie Tooth disease (CMT) still represent an issue. A recent study highlighted that three additional clinical OMs, the 10 meters walk test (10MWT), 9 hole-peg test, and foot dorsal flexion dynamometry, further improve discrimination between severely and mildly affected patients. Another study recently assess the validity and reliability of the 6 Minutes Walking test (6MWT). AIM: To identify the most useful scales in the clinical evaluation of CMT1A patients...
June 11, 2018: European Journal of Physical and Rehabilitation Medicine
Marisa Sanchez, Zebin Xia, Elizabeth Rico-Bautista, Xihua Cao, Michael Cuddy, David J Castro, Ricardo G Correa, Liqun Chen, Jinghua Yu, Andrey Bobkov, Vivian Ruvolo, Michael Andreeff, Robert G Oshima, Shu-Ichi Matsuzawa, John C Reed, Xiao-Kun Zhang, Donna Hansel, Dieter A Wolf, Marcia I Dawson
Di(1 H -indol-3-yl)(4-trifluoromethylphenyl)methane (DIM-Ph-4-CF3 ) is an analog of orphan nuclear receptor 4A1 (NR4A1) ligand cytosporone B. We have synthesized several oxidation products of DIM-Ph-4-CF3 , focusing on analogs with electron-withdrawing or donating groups at their phenyl ring 4-positions, and examined their anti-cancer activity and mechanism-of-action. Mesylates (DIM-Ph-4-X+ OMs- s) having CF3 , CO2 Me and Cl groups were more effective inhibitors of cancer cell viability than their precursors...
May 18, 2018: Oncotarget
Kevin C Lee, Sidney B Eisig, Alia Koch
PURPOSE: Prospective applicants use residency program websites (PWs) to evaluate programs when deciding where to apply, interview, and rank. The purpose of this study was to evaluate the content of oral and maxillofacial surgery (OMS) PWs. MATERIALS AND METHODS: This is a cross-sectional study of all OMS programs accredited by the Commission on Dental Accreditation. PWs were identified through the American Association of Oral and Maxillofacial Surgeons Program Directory (AAOMS-PD) and a secondary internet search...
May 25, 2018: Journal of Oral and Maxillofacial Surgery
Tengfei Huang, Qiang Wang, Wenjie Yu, Xuefeng Wang, Lester Andrews
Infrared absorptions of the matrix isolated OMS, OM(η2-SO), and OM(η2-SO)(η2-O2S) (M = Ce, Th) molecules were observed following reactions of laser-ablated Ce and Th metal atoms with SO2 during condensation in excess argon and neon. Band assignments for the main vibrational modes were confirmed by appropriate 34SO2 and S18O2 isotopic shifts. B3LYP, BPW91 density functional and CASSCF/CASPT2 calculations were performed to characterize these new reaction products and to explore the admixture of f orbitals into the bonding giving stronger triple M≡O bonds...
May 30, 2018: Journal of Physical Chemistry. A
Jennifer L Moore, Svein Friis, Ian D Graham, Elisabeth Troøyen Gundersen, Jan E Nordvik
BACKGROUND: The South Eastern Health Region in Norway serves approximately 2.8 million people, which is more than half of Norway's population. Physical medicine and rehabilitation services are provided by 9 public hospital trusts and 30 private rehabilitation facilities. The purposes of this study were to conduct a psychometric analysis of the EBP Implementation Scale (EBPIS) and describe rehabilitation clinicians' self-reported 1) use of evidence-based practices (EBPs), 2) use of EBPs across hospitals, and 3) determine factors associated with use of EBPs in the South Eastern Health Region in Norway...
May 25, 2018: BMC Health Services Research
Andrew A Fingelkurts, Alexander A Fingelkurts
Background and Objective: Understanding how trauma impacts the self-structure of individuals suffering from the Post-Traumatic Stress Disorder (PTSD) symptoms is a complex matter and despite several attempts to explain the relationship between trauma and the "Self", this issue still lacks clarity. Therefore, adopting a new theoretical perspective may help understand PTSD deeper and to shed light on the underlying psychophysiological mechanisms. Methods: In this study, we employed the "three-dimensional construct model of the experiential selfhood" where three major components of selfhood (phenomenal first-person agency, embodiment, and reflection/narration) are related to three Operational Modules (OMs) of the self-referential brain network...
2018: Open Neuroimaging Journal
Thomas Simon, Emmanuel Cheuret, Léa Fiedler, Catherine Mengelle, Eloïse Baudou, Kumaran Deiva
Opso-myoclonus syndrome (OMS) is a very rare and severe condition. Ataxia, opsoclonus, myoclonus and/or behavioral and sleeping disturbances define that autoimmune disorder syndrome which is paraneoplastic or triggered by an infection. Here, we report a 3 year-old immunocompetent boy who developed an atypical OMS which was later complicated by an acute transverse myelitis. Screening for neuroblastoma was negative and extensive infectious screening revealed an active HHV-6 infection confirmed by blood and cerebrospinal fluid PCR...
May 8, 2018: European Journal of Paediatric Neurology: EJPN
Sarah J Cooper, Ganesh Krishnamoorthy, David Wolloscheck, John K Walker, Valentin V Rybenkov, Jerry M Parks, Helen I Zgurskaya
The permeability barrier of Gram-negative cell envelopes is the major obstacle in the discovery and development of new antibiotics. In Gram-negative bacteria, these difficulties are exacerbated by the synergistic interaction between two biochemically distinct phenomena, the low permeability of the outer membrane (OM) and active multidrug efflux. In this study, we used Pseudomonas aeruginosa and Escherichia coli strains with controllable permeability barriers, achieved through hyperporination of the OMs and varied efflux capacities, to evaluate the contributions of each of the barriers to protection from antibacterials...
May 25, 2018: ACS Infectious Diseases
Michael R Pranzatelli, Elizabeth D Tate, Nathan R McGee
BACKGROUND: Pediatric opsoclonus-myoclonus syndrome (OMS) presents a paradox of etiopathogenesis: A neuroblastic tumor (NB) is found in only one half of the cases, the others are ascribed to infections or designated as idiopathic. METHOD: From an IRB-approved observational study of 356 US children with OMS, secondary analysis of "etiology" and related factors was performed on a well-characterized cohort. The "Tumor" (n = 173) and "No Tumor" groups (n = 183), as defined radiologically, were compared according to multiple factors considered potentially differentiating...
May 4, 2018: Pediatric Blood & Cancer
An Tran-Duy, David C Smerdon, Philip M Clarke
BACKGROUND: While there is strong evidence showing the survival advantage of elite athletes, much less is known about those engaged in mind sports such as chess. This study aimed to examine the overall as well as regional survival of International Chess Grandmasters (GMs) with a reference to the general population, and compare relative survival (RS) of GMs with that of Olympic medallists (OMs). METHODS: Information on 1,208 GMs and 15,157 OMs, respectively, from 28 countries were extracted from the publicly available data sources...
2018: PloS One
Tai-Shuang Yin, Xin-You Lü, Liang-Liang Wan, Shang-Wu Bin, Ying Wu
We propose a scheme to significantly enhance the cross-Kerr (CK) nonlinearity between photons and phonons in a quadratically coupled optomechanical system (OMS) with two-photon driving. This CK nonlinear enhancement originates from the parametric-driving-induced squeezing and the underlying nonlinear optomechanical interaction. Moreover, the noise of the squeezed mode can be suppressed completely by introducing a squeezed vacuum reservoir. As a result of this dramatic nonlinear enhancement and the suppressed noise, we demonstrate the feasibility of the quantum nondemolition measurement of the phonon number in an originally weak coupled OMS...
May 1, 2018: Optics Letters
Jordi Berenguer, Tonny Lagerweij, Xi Wen Zhao, Sophie Dusoswa, Petra van der Stoop, Bart Westerman, Mark C de Gooijer, Marloes Zoetemelk, Anoek Zomer, Matheus H W Crommentuijn, Laurine E Wedekind, Àlan López-López, Alberta Giovanazzi, Marina Bruch-Oms, Ida H van der Meulen-Muileman, Rogier M Reijmers, Toin H van Kuppevelt, Juan-Jesús García-Vallejo, Yvette van Kooyk, Bakhos A Tannous, Pieter Wesseling, Danijela Koppers-Lalic, W Peter Vandertop, David P Noske, Victor W van Beusechem, Jacco van Rheenen, D Michiel Pegtel, Olaf van Tellingen, Thomas Wurdinger
Cancer cells release extracellular vesicles (EVs) that contain functional biomolecules such as RNA and proteins. EVs are transferred to recipient cancer cells and can promote tumour progression and therapy resistance. Through RNAi screening, we identified a novel EV uptake mechanism involving a triple interaction between the chemokine receptor CCR8 on the cells, glycans exposed on EVs and the soluble ligand CCL18. This ligand acts as bridging molecule, connecting EVs to cancer cells. We show that glioblastoma EVs promote cell proliferation and resistance to the alkylating agent temozolomide (TMZ)...
2018: Journal of Extracellular Vesicles
Michael R Pranzatelli, Nathan R McGee, Elizabeth D Tate
In 208 children with opsoclonus-myoclonus syndrome (OMS), CSF IgG oligoclonal bands (OCB) and 22 immunomarkers in CSF and 21 in serum/blood were measured. In 36 untreated OMS, 58% were OCB(+), whereas 55% of treated OMS were OCB(-). OCB positivity or negativity did not alter concentrations or frequencies of immunomarkers. The phenotypes of OCB(+) and OCB(-) patients were not distinctive. CSF B cells were expanded in untreated OMS regardless of OCB positivity. These data reveal a much higher frequency of OCB positivity in untreated OMS than previously realized and a disconnect between intrathecal OCB and inflammatory mediator production...
April 12, 2018: Journal of Neuroimmunology
Bruno R Chrcanovic, Ricardo S Gomez
The aim of the present study was to integrate the available data published on odontogenic myxoma (OM) into a comprehensive analysis of its clinical/radiological features. Electronic search undertaken in January/2018, looking for publications reporting cases of OM. A total of 377 publications were included. We identified 1,692 lesions, and 695 were used for the analysis of recurrence. There is a predominance of OMs in females and in mandibles. OMs usually present with bone expansion, asymptomatic cortical perforation, and a multilocular appearance...
April 23, 2018: Oral Diseases
M-C González-Galván, A Mosqueda-Taylor, R Bologna-Molina, A Setien-Olarra, X Marichalar-Mendia, J-M Aguirre-Urizar
BACKGROUND: Odontogenic myxoma (OM) is a benign intraosseous neoplasm that exhibits local aggressiveness and high recurrence rates. Osteoclastogenesis is an important phenomenon in the tumor growth of maxillary neoplasms. RANK (Receptor Activator of Nuclear Factor κappa B) is the signaling receptor of RANK-L (Receptor activator of nuclear factor kappa-Β ligand) that activates the osteoclasts. OPG (osteoprotegerin) is a decoy receptor for RANK-L that inhibits pro-osteoclastogenesis. The RANK / RANKL / OPG system participates in the regulation of osteolytic activity under normal conditions, and its alteration has been associated with greater bone destruction, and also with tumor growth...
May 1, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
Hanna Sternby, Federico Bolado, Héctor J Canaval-Zuleta, Carlos Marra-López, Ana I Hernando-Alonso, Adolfo Del-Val-Antoñana, Guillermo García-Rayado, Robin Rivera-Irigoin, Francisco J Grau-García, Lluís Oms, Judith Millastre-Bocos, Isabel Pascual-Moreno, David Martínez-Ares, Juan A Rodríguez-Oballe, Antonio López-Serrano, María L Ruiz-Rebollo, Alejandro Viejo-Almanzor, Belén González-de-la-Higuera, Aitor Orive-Calzada, Ignacio Gómez-Anta, José Pamies-Guilabert, Fátima Fernández-Gutiérrez-Del-Álamo, Isabel Iranzo-González-Cruz, Mónica E Pérez-Muñante, María D Esteba, Ana Pardillos-Tomé, Pedro Zapater, Enrique de-Madaria
OBJECTIVE: The aim of this study was to compare and validate the different classifications of severity in acute pancreatitis (AP) and to investigate which characteristics of the disease are associated with worse outcomes. SUMMARY OF BACKGROUND DATA: AP is a heterogeneous disease, ranging from uneventful cases to patients with considerable morbidity and high mortality rates. Severity classifications based on legitimate determinants of severity are important to correctly describe the course of disease...
April 18, 2018: Annals of Surgery
Fareedi Mukram Ali, Ghassan M Al-Iryani, Sultan Mohammed Namis, Asma Ali Hezam, Salma Abdu Swaid, Anas Esam Alomar
BACKGROUND: In many health services communities the scope of oral and maxillofacial surgery (OMFS) as a discipline is frequently not probably understood. Good awareness towards OMFS among different branches of health services providers is essential for better referral strategies and will be for the benefit of the patient. MATERIALS AND METHODS: The cross-sectional study was done using a specially prepared questionnaire distributed randomly to 125 general medical practitioners working in Jazan province...
March 15, 2018: Open Access Macedonian Journal of Medical Sciences
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