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https://www.readbyqxmd.com/read/28735502/regenerative-medicine-in-kidney-disease-where-we-stand-and-where-to-go
#1
REVIEW
Fernanda T Borges, Nestor Schor
The kidney is a complex organ with more than 20 types of specialized cells that play an important role in maintaining the body's homeostasis. The epithelial tubular cell is formed during embryonic development and has little proliferative capacity under physiological conditions, but after acute injury the kidney does have regenerative capacity. However, after repetitive or severe lesions, it may undergo a maladaptation process that predisposes it to chronic kidney injury. Regenerative medicine includes various repair and regeneration techniques, and these have gained increasing attention in the scientific literature...
July 22, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28735450/prescription-drug-price-paradox-cost-analysis-of-canadian-online-pharmacies-versus-us-medicare-beneficiaries-for-the-top-100-drugs
#2
Sean Hyungwoo Kim, Young Joo Ryu, Na-Eun Cho, Andy Eunwoo Kim, Jongwha Chang
BACKGROUND AND OBJECTIVES: Despite the introduction of Medicare Part D (MPD) and 2012 Affordable Care Act (ACA), patients have a cost burden due to increases in drug prices. To overcome cost barriers, some patients purchase their medications from Canadian online pharmacies as Canadian prescription drug prices are believed to be lower than US prescription drug prices. The objective of this study was to determine which top 100 Medicare drugs can be imported to the USA legally, and to determine which type of prescription drug would be more beneficial to be purchased from Canadian online pharmacies...
July 22, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28735447/cost-benefit-analysis-of-two-child-abuse-and-neglect-primary-prevention-programs-for-us-states
#3
Cora Peterson, Curtis Florence, Robert Thomas, Joanne Klevens
We assessed the US state-level budget and societal impact of implementing two child abuse and neglect (CAN) primary prevention programs. CAN cost estimates and data from two prevention programs (Child-Parent Centers and Nurse-Family Partnership) were combined with current population, cost, and CAN incidence data by US state. A cost-benefit mathematical model for each program by US state compared program costs with the future monetary value of benefits from reduced CAN. The models used a lifetime time horizon from government payer and societal perspectives...
July 22, 2017: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/28735376/the-socio-economic-impact-of-bariatric-surgery
#4
Arendse Tange Larsen, Betina Højgaard, Rikke Ibsen, Jakob Kjellberg
INTRODUCTION: A recurring argument for bariatric surgery is cost savings due to sustained weight loss and reductions in comorbidities. However, studies prompting this argument tend to focus only on health care costs, and in some of them, cost changes after surgery have been modelled. The aim of this study was to generate real-world evidence on the socio-economic impact of bariatric surgery, by evaluating the effect on both direct and indirect costs. MATERIALS AND METHODS: Using real-world data from national registries, predictions of health care costs, social transfer payments and income were performed for a surgically treated individual and compared to those for a similar but non-surgically treated individual 3 years before and after surgery...
July 22, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28735373/systematic-heuristic-evaluation-of-computerized-consultation-order-templates-clinicians-and-human-factors-engineers-perspectives
#5
April Savoy, Himalaya Patel, Mindy E Flanagan, Michael Weiner, Alissa L Russ
We assessed the usability of consultation order templates and identified problems to prioritize in design efforts for improving referral communication. With a sample of 26 consultation order templates, three evaluators performed a usability heuristic evaluation. The evaluation used 14 domain-independent heuristics and the following three supplemental references: 1 new domain-specific heuristic, 6 usability goals, and coded clinicians' statements regarding ease of use for 10 sampled templates. Evaluators found 201 violations, a mean of 7...
August 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28735089/biodeterioration-of-marble-in-an-underwater-environment
#6
Beatriz Cámara, Mónica Álvarez de Buergo, Manuel Bethencourt, Tomás Fernández-Montblanc, Mauro F La Russa, Michela Ricca, Rafael Fort
This study examines the deterioration of geomaterials used throughout history that today may be found lying on the ocean floor. Submerged archaeological sites including cargoes from shipwrecks or ancient city ruins have been a topic of interest from a perspective of in situ musealization, as a way of making underwater cultural heritage accessible to the public. In an experimental study conducted at an underwater archaeological site in the Bay of Cádiz (SW Spain), we subjected two types of marble (Carrara and Macael) to three conditions to which submerged archaeological objects are often exposed: full exposure to the water column, natural processes of burial and unearthing, or permanent burial...
July 20, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28734989/hydroxyvitamin-d-assays-an-historical-perspective-from-deqas
#7
G D Carter, J Berry, R Durazo-Arvizu, E Gunter, G Jones, J Jones, H L J Makin, P Pattni, C T Sempos, P Twomey, E L Williams, S A Wise
Recent years have seen a substantial increase in demand for 25-hydroxyvitamin D (25-OHD) assays. DEQAS (the Vitamin D External Quality Assessment Scheme) has been monitoring the performance of these assays since 1989. The first DEQAS distribution was in June 1989 and results were submitted by 13 laboratories in the UK, two of which used HPLC/UV; the rest used ligand binding assays with a tritium tracer. Inter-laboratory CVs (ALTM) ranged from 29.3% (42.7 nmol/L) to 53.7% (20.0 nmol/L). Currently the scheme has participants in 56 countries using 30 methods or variants of methods...
July 19, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28734964/removing-user-fees-for-health-services-a-multi-epistemological-perspective-on-access-inequities-in-senegal
#8
Philipa Mladovsky, Maymouna Ba
Plan Sésame (PS) is a user fee exemption policy launched in 2006 to provide free access to health services to Senegalese citizens aged 60 and over. Analysis of a large household survey evaluating PS echoes findings of other studies showing that user fee removal can be highly inequitable. 34 semi-structured interviews and 19 focus group discussions with people aged 60 and over were conducted in four regions in Senegal (Dakar, Diourbel, Matam and Tambacounda) over a period of six months during 2012. They were analysed to identify underlying causes of exclusion from/inclusion in PS and triangulated with the household survey...
July 6, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28734864/reasons-for-seeking-clinical-care-for-lower-urinary-tract-symptoms-a-mixed-methods-study
#9
James W Griffith, Emily E Messersmith, Brenda W Gillespie, Jonathan B Wiseman, Kathryn E Flynn, Ziya Kirkali, John W Kusek, Tamara Bavendam, David Cella, Karl J Kreder, Jasmine J Nero, Maria E Corona, Catherine S Bradley, Kimberly S Kenton, Brian T Helfand, Robert M Merion, Kevin P Weinfurt
PURPOSE: The primary objective of this study was to evaluate reasons for seeking care among men and women with lower urinary tract symptoms (LUTS). METHODS: Participants were recruited from urology and urogynecology clinics, and the community. The sample was enriched with persons expected to have abnormal or diminished bladder sensations (e.g., participants with lower back surgery, participants aged 65+). In-person interviews were conducted, beginning with an open-ended assessment of urinary symptoms and associated bother, followed by more directed questions, including reasons for seeking or not seeking treatment...
July 19, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28734518/influenza-a-global-perspective
#10
REVIEW
Elizabeth T Rotrosen, Kathleen M Neuzil
Influenza is a common respiratory illness in children and accounts for substantial morbidity and mortality on an annual basis. Inactivated and live influenza vaccines are approved for children and are safe and efficacious. The absolute effectiveness of vaccines varies by year and is influenced by several factors. The reason for recent reduced performance of live-attenuated influenza vaccines is poorly understood, and active research is ongoing. Vaccination programs are less common in tropical and subtropical countries, where unique logistical and feasibility challenges exist...
August 2017: Pediatric Clinics of North America
https://www.readbyqxmd.com/read/28734484/college-nursing-faculty-job-satisfaction-and-retention-a-national-perspective
#11
Peggy Lee, Michael T Miller, Thomas A Kippenbrock, Chris Rosen, Jan Emory
The need for registered nurses in the United States continues to grow. To meet this need for increased numbers of nurses, recruitment and retention of qualified nurse educators has become a priority. In addition, the factors associated with nursing faculties' intent to stay have emerged as important considerations for administrators. The concepts of job satisfaction and intent to stay become vital to recruiting and retaining nursing faculty. In the past decade few empirical studies have been conducted on a national scale to address job satisfaction and intent to stay in academia...
July 2017: Journal of Professional Nursing: Official Journal of the American Association of Colleges of Nursing
https://www.readbyqxmd.com/read/28734365/automatic-feed-phase-identification-in-multivariate-bioprocess-profiles-by-sequential-binary-classification
#12
Ramin Nikzad-Langerodi, Edwin Lughofer, Susanne Saminger-Platz, Thomas Zahel, Patrick Sagmeister, Christoph Herwig
In this paper, we propose a new strategy for retrospective identification of feed phases from online sensor-data enriched feed profiles of an Escherichia Coli (E. coli) fed-batch fermentation process. In contrast to conventional (static), data-driven multi-class machine learning (ML), we exploit process knowledge in order to constrain our classification system yielding more parsimonious models compared to static ML approaches. In particular, we enforce unidirectionality on a set of binary, multivariate classifiers trained to discriminate between adjacent feed phases by linking the classifiers through a one-way switch...
August 22, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28734289/perspective-photocatalytic-reduction-of-co2-to-solar-fuels-over-semiconductors
#13
Chao Peng, Glenn Reid, Haifeng Wang, P Hu
Increasing emissions of carbon dioxide and the depletion of finite fossil fuels have led to many concerns about global warming and energy crises. Consequently, a sustainable and alternative method, photocatalytic CO2 reduction to chemical fuels has received considerable attention. This perspective highlights recent knowledge and the main challenges in CO2 photoreduction primarily from the theoretical field. The fundamental understanding of CO2 adsorption and reaction mechanism at an atomic level is fully addressed, and the relevant effects dominating the process of CO2 photoreduction are also elucidated...
July 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28734220/effect-analysis-of-quantum-chemical-descriptors-and-substituent-characteristics-on-henry-s-law-constants-of-polybrominated-diphenyl-ethers-at-different-temperatures
#14
Jiang Long, Qiu Youli, Li Yu
Twelve substituent descriptors, 17 quantum chemical descriptors and 1/T were selected to establish a quantitative structure-property relationship (QSPR) model of Henry's law constants for 7 polybrominated diphenyl ethers (PBDEs) at five different temperatures. Then, the lgH of 202 congeners at different temperatures were predicted. The variation rule and regulating mechanism of lgH was studied from the perspectives of both quantum chemical descriptors and substituent characteristics. The R(2) for modeling and testing sets of the final QSPR model are 0...
July 19, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28734014/improving-postmortem-testing-for-perinatal-death-from-the-parents-perspective
#15
Lindsey J Wimmer, Claire Storey, Robert Silver
Parents experiencing the death of a baby through stillbirth, neonatal death, or other perinatal losses are required to make several decisions while under a great deal of emotional distress. One such decision is whether or not to pursue testing that could provide more information about their baby's death. Lewis and colleagues state that postmortem testing is the most valuable tool available to learn about cause of death and implications for future health and pregnancies. This article is protected by copyright...
July 22, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28734004/comparison-of-preferences-of-healthcare-professionals-and-ms-patients-for-attributes-of-disease-modifying-drugs-a-best-worst-scaling
#16
Ingrid E H Kremer, Silvia M A A Evers, Peter J Jongen, Mickaël Hiligsmann
BACKGROUND: The choice between disease-modifying drugs (DMDs) for the treatment of multiple sclerosis (MS) becomes more often a shared decision between the patient and the neurologist and MS nurse. This study aimed to assess which DMD attributes are most important for the healthcare professionals in selecting a DMD for a patient. Subsequently, within this perspective, the neurologists' and nurses' perspectives were compared. Lastly, the healthcare professionals' perspective was compared with the patients' perspective to detect any differences that may need attention in the communication about DMDs...
July 21, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/28733904/polyamines-therapeutic-perspectives-in-oxidative-stress-and-inflammatory-diseases
#17
REVIEW
Tarique Hussain, Bie Tan, Wenkai Ren, Najma Rahu, Rahim Dad, Dildar Hussain Kalhoro, Yulong Yin
Polyamines are naturally occurring aliphatic compounds, particularly essential elements for biological functions. These compounds play a central role in regulating molecular pathways which are responsible for cellular proliferation, growth, and differentiation. Importantly, excessive polyamine catabolism can lead to a prominent source of oxidative stress which increases inflammatory response and thought to be involved in several diseases including stroke, renal failure, neurological disease, liver disease, and even cancer...
July 21, 2017: Amino Acids
https://www.readbyqxmd.com/read/28733894/risk-and-maintenance-factors-for-young-women-s-dsm-5-eating-disorders
#18
Antonios Dakanalis, Massimo Clerici, Francesco Bartoli, Manuela Caslini, Cristina Crocamo, Giuseppe Riva, Giuseppe Carrà
Recent research with young women attending colleges, who are at the average age of eating disorder (ED) onset, established that the ED symptoms are not only prevalent but also relatively stable over the college period. Nonetheless, our knowledge regarding the course and modifiable factors associated with both the onset and maintenance of diagnosable (DSM-5) EDs in this population is limited. The objective of this report was to address these key research gaps. Data were examined from 2713 women who completed assessments of potential vulnerability factors and EDs in the autumn semester of the first (baseline) and fourth (follow-up) college years...
July 21, 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/28733796/beyond-integrating-social-sciences-reflecting-on-the-place-of-life-sciences-in-empirical-bioethics-methodologies
#19
Marcel Mertz, Jan Schildmann
Empirical bioethics is commonly understood as integrating empirical research with normative-ethical research in order to address an ethical issue. Methodological analyses in empirical bioethics mainly focus on the integration of socio-empirical sciences (e.g. sociology or psychology) and normative ethics. But while there are numerous multidisciplinary research projects combining life sciences and normative ethics, there is few explicit methodological reflection on how to integrate both fields, or about the goals and rationales of such interdisciplinary cooperation...
July 21, 2017: Medicine, Health Care, and Philosophy
https://www.readbyqxmd.com/read/28733787/gatekeepers-perceptions-of-the-quality-and-availability-of-services-for-breast-and-cervical-cancer-patients-in-the-english-speaking-windward-islands-an-exploratory-investigation
#20
Kamilah B Thomas-Purcell, Will L Tarver, Christine Richards, Marva Primus-Joseph
PURPOSE: Although extensive screening services for breast and cervical cancers are available in the Caribbean, these cancers continue to be the leading causes of cancer death among women in this region. The purpose of this study was to determine the quality and availability of breast and cervical cancer treatment care and support services from the perspective of the gatekeepers who provide care for the patients in the Windward Islands of Dominica, Grenada, St Lucia, and St. Vincent. METHODS: A qualitative research design using semi-structured, in-depth interviews was used to gather data from gatekeepers who provided oncology prevention and care services to patients for at least one year...
July 21, 2017: Cancer Causes & Control: CCC
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