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https://www.readbyqxmd.com/read/28618915/coronary-artery-disease-risk-stratification-and-patient-selection-for-more-aggressive-secondary-prevention
#1
François Schiele, Fiona Ecarnot, Romain Chopard
In patients with stable coronary artery disease, clinical outcomes are predominantly characterized by the consequences of atherosclerosis on the myocardium, but also by complications of atherosclerosis, notably recurrent acute coronary syndrome or stroke. Secondary prevention therapy is therefore key in this patient population. Intensification of secondary prevention therapy is possible, at the price of a therapeutic risk or a high cost, therefore justifying careful selection of patients with a high residual risk and low therapeutic risk...
June 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28574177/review-of-basal-plus-insulin-regimen-options-for-simpler-insulin-intensification-in-people-with-type-2-diabetes-mellitus
#2
REVIEW
D Raccah, D Huet, A Dib, F Joseph, B Landers, J Escalada, H Schmitt
AIMS: To identify simple insulin regimens for people with Type 2 diabetes mellitus that can be accepted and implemented earlier in primary and specialist care, taking into consideration each individual's needs and capabilities. METHODS: Using randomized clinical trials identified by a search of the PubMed database, as well as systematic reviews, meta-analyses and proof-of-concept studies, this review addresses topics of interest related to the progressive intensification of a basal insulin regimen to a basal-plus regimen (one basal insulin injection plus stepwise addition of one to three preprandial short-acting insulin injections/day) vs a basal-bolus regimen (basal insulin plus three short-acting insulin injections per day) in people with Type 2 diabetes...
June 2, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28573408/practical-recommendations-for-transitioning-patients-with-type-2-diabetes-from-hospital-to-home
#3
REVIEW
Amy C Donihi
PURPOSE OF REVIEW: The purpose of this review is to provide practical evidence-based recommendations for transitioning hospitalized patients with type 2 diabetes (T2DM) to home. RECENT FINDINGS: Hospitalized patients who have newly diagnosed or poorly controlled T2DM require initiation or intensification of their outpatient diabetes regimen. Potential barriers to medication access and continuity of care should be identified early in the hospitalization. Throughout hospitalization, patients should receive diabetes education focused on basic survival skills and tailored to learning needs...
July 2017: Current Diabetes Reports
https://www.readbyqxmd.com/read/28555374/the-cisplatin-total-dose-and-concomitant-radiation-in-locoregionally-advanced-head-and-neck-cancer-any-recent-evidence-for-dose-efficacy
#4
REVIEW
Lindsay Carlsson, Scott V Bratman, Lillian L Siu, Anna Spreafico
Concurrent chemoradiotherapy (CRT) with high-dose (100 mg/m(2)), single-agent cisplatin is considered the standard of care for locoregionally advanced head and neck cancer (LAHNC). Poor compliance often due to significant treatment-related toxicities observed during CRT regimen has stimulated research efforts to examine for evidence of the optimal cumulative cisplatin dose and schedule. The findings from this systematic literature review demonstrate that there are insufficient prospective, randomized controlled data to determine the optimal total dose (and schedule) of cisplatin to administer concomitantly with radiotherapy in the treatment of LAHNC...
July 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/28553609/choice-of-insulin-in-type-2-diabetes-a-southeast-asian-perspective
#5
Sanjay Kalra, Hong Quang Thai, Chaicharn Deerochanawong, Goh Su-Yen, Mafauzy Mohamed, Tint Swe Latt, Than Than Aye, Zafar Ahmed Latif, Prasad Katulanda, Touch Khun, Sum Satha, Vadsana Vongvandy
Southeast Asia faces a diabetes epidemic, which has created significant challenges for health care. The unique Asian diabetes phenotype, coupled with peculiar lifestyle, diet, and healthcare-seeking behavior, makes it imperative to develop clinical pathways and guidelines which address local needs and requirements. From an insulin-centric viewpoint, the preparations prescribed in such pathways should be effective, safe, well tolerated, nonintrusive, and suitable for the use in multiple clinical situations including initiation and intensification...
May 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28551769/clinical-course-and-end-of-life-care-in-patients-who-have-died-after-allogeneic-stem-cell-transplantation
#6
Christoph Busemann, Andreas Jülich, Britta Buchhold, Vanessa Schmidt, Laila Schneidewind, Daniel Pink, Christian Andreas Schmidt, Thomas Neumann, William H Krüger
PURPOSE: Allogeneic stem cell transplantation may cure approximately 50% of patients, however, a significant part of the other half might benefit from a high-quality palliative care medicine at the end of life. Somatic, psychic and spiritual needs of these patients may differ from those of patients suffering from incurable solid tumours and are not comprehensively evaluated so far. METHODS: To address this question, data from charts of 123 patients who have died after allogeneic stem cell transplantation were extracted...
May 27, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28500214/efficacy-of-the-telemedical-lifestyle-intervention-program-telipro-in-advanced-stages-of-type-2-diabetes-a-randomized-controlled-trial
#7
Kerstin Kempf, Bernd Altpeter, Janine Berger, Oliver Reuß, Matthias Fuchs, Michael Schneider, Babette Gärtner, Katja Niedermeier, Stephan Martin
OBJECTIVE: Lifestyle interventions are the foundation of treatment in newly diagnosed type 2 diabetes. However, their therapeutic potential in advanced disease stages is unknown. We evaluated the efficacy of the Telemedical Lifestyle intervention Program (TeLiPro) in improving metabolic control in advanced-stage type 2 diabetes. RESEARCH DESIGN AND METHODS: In this single-blind, active comparator, intervention study, patients with type 2 diabetes (with glycated hemoglobin [HbA1c] ≥7...
May 12, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28490797/action-on-diabetic-macular-oedema-achieving-optimal-patient-management-in-treating-visual-impairment-due-to-diabetic-eye-disease
#8
R Gale, P H Scanlon, M Evans, F Ghanchi, Y Yang, G Silvestri, M Freeman, A Maisey, J Napier
This paper identifies best practice recommendations for managing diabetes and sight-threatening diabetic eye disease. The authors provide an update for ophthalmologists and allied healthcare professionals on key aspects of diabetes management, supported by a review of the pertinent literature, and recommend practice principles for optimal patient management in treating visual impairment due to diabetic eye disease. In people with diabetes, early optimal glycaemic control reduces the long-term risk of both microvascular and macrovascular complications...
May 2017: Eye
https://www.readbyqxmd.com/read/28475268/prospective-evaluation-of-quality-of-life-in-children-treated-in-ukall-2003-for-acute-lymphoblastic-leukaemia-a-cohort-study
#9
C Eiser, C B Stride, A Vora, N Goulden, C Mitchell, G Buck, M Adams, M E M Jenney
BACKGROUND: Health-related quality of life (HRQoL) from diagnosis until end of treatment for children with acute lymphoblastic leukaemia was investigated, examining effects of age, gender, risk-stratified treatment regimen, and therapy intensity (one vs. two 'delayed intensifications' [DIs]). METHOD: In a multi-centre prospective study, parents reported their child's generic and disease-specific HRQoL and their own care-giving burden at five time points. From 1,428 eligible patients, 874 parents completed questionnaires at least once during treatment...
May 5, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28460836/the-role-of-meat-in-strategies-to-achieve-a-sustainable-diet-lower-in-greenhouse-gas-emissions-a-review
#10
REVIEW
John J Hyland, Maeve Henchion, Mary McCarthy, Sinéad N McCarthy
Food consumption is responsible for a considerable proportion of greenhouse gas emissions (GHGE). Hence, individual food choices have the potential to substantially influence both public health and the environment. Meat and animal products are relatively high in GHGE and therefore targeted in efforts to reduce dietary emissions. This review first highlights the complexities regarding sustainability in terms of meat consumption and thereafter discusses possible strategies that could be implemented to mitigate its climatic impact...
April 21, 2017: Meat Science
https://www.readbyqxmd.com/read/28459925/effect-of-a-community-health-worker-intervention-among-latinos-with-poorly-controlled-type-2-diabetes-the-miami-healthy-heart-initiative-randomized-clinical-trial
#11
Olveen Carrasquillo, Cynthia Lebron, Yisel Alonzo, Hua Li, Aileen Chang, Sonjia Kenya
Importance: Community health worker (CHW) intervention is a promising approach to address type 2 diabetes among Latinos. However, evidence from randomized clinical studies is limited. Objective: To compare a CHW intervention with enhanced usual care. Design, Setting, and Participants: This 52-week, single-blind, randomized clinical trial included 300 Latino adults aged 18 to 65 years who were treated in 2 public hospital outpatient clinics in Miami-Dade County, Florida, from July 1, 2010, through October 31, 2013...
May 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28457028/consensus-on-insulin-dose-and-titration-algorithms-in-ambulatory-care-of-type-2-diabetes-in-india
#12
Rajiv Kovil, Manoj Chawla, Rajesh Rajput, A K Singh, Binayak Sinha, Samit Ghosal, Piya Ballani, Sunil Gupta, Snehal Tanna, S M Bandukwala, Tejas Shah, Vijay Negalur, Anil Bhoraskar, S R Aravind, Abdul H Zargar, Jothydev Kesavadev, Ashok Kumar Das
INSTRUCTION: Insulin is the oldest of the currently available treatment options in Type 2 diabetes mellitus (T2DM) and is considered as the most effective glucose lowering agent. Despite this, decision on starting insulin therapy is often delayed in India as well as worldwide due to various barriers at both patient and physician levels. Appropriate insulin dosing and titration is also critical to the successful achievement of tight glycaemic control. OBJECTIVE: To provide simple and easily implementable guidelines to primary care physicians on appropriate insulin dosing and titration of various insulin regimens for both initiation and intensification...
February 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28453521/soy-moratorium-impacts-on-soybean-and-deforestation-dynamics-in-mato-grosso-brazil
#13
Jude H Kastens, J Christopher Brown, Alexandre Camargo Coutinho, Christopher R Bishop, Júlio César D M Esquerdo
Previous research has established the usefulness of remotely sensed vegetation index (VI) data from the Moderate Resolution Imaging Spectroradiometer (MODIS) to characterize the spatial dynamics of agriculture in the state of Mato Grosso (MT), Brazil. With these data it has become possible to track MT agriculture, which accounts for ~85% of Brazilian Amazon soy production, across periods of several years. Annual land cover (LC) maps support investigation of the spatiotemporal dynamics of agriculture as they relate to forest cover and governance and policy efforts to lower deforestation rates...
2017: PloS One
https://www.readbyqxmd.com/read/28451850/drug-induced-hypertension-focus-on-mechanisms-and-management
#14
REVIEW
Alexandra R Lovell, Michael E Ernst
PURPOSE OF REVIEW: This review is intended to briefly describe the primary mechanistic pathways by which several common drugs can increase blood pressure. We also propose potential management strategies based on the underlying mechanisms responsible for the blood pressure elevation. RECENT FINDINGS: As hypertension is a significant risk factor for cardiovascular events, healthcare providers must evaluate patients' concomitant medications that may contribute to elevations in blood pressure...
May 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28442825/exploring-approaches-to-facilitate-diabetes-therapy-intensification-in-primary-care
#15
Jodi Krall, Kendra Durdock, Patricia Johnson, Justin Kanter, Janice Koshinsky, Margaret Thearle, Linda Siminerio
No abstract text is available yet for this article.
April 2017: Clinical Diabetes: a Publication of the American Diabetes Association
https://www.readbyqxmd.com/read/28441696/declining-blood-pressure-and-intensification-of-blood-pressure-management-among-people-over-80-years-cohort-study-using-electronic-health-records
#16
Rathi Ravindrarajah, Alex Dregan, Nisha C Hazra, Shota Hamada, Stephen H D Jackson, Martin C Gulliford
BACKGROUND: Management of high blood pressure (BP) in people over 80 years is controversial, but there is limited information available concerning the uptake of hypertension treatment at this age. OBJECTIVE: To evaluate use of antihypertensive drugs and changes in SBP and DBP from 2001 to 2014 in men and women aged 80 years and over. METHODS: Cohort study using primary care electronic health records of 265 225 participants from the UK Clinical Practice Research Datalink...
June 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28432585/patterns-of-care-and-treatment-outcomes-in-older-adults-with-low-grade-glioma-a-50-year-experience
#17
Ryan S Youland, David A Schomas, Paul D Brown, Ian F Parney, Nadia N I Laack
The purpose of this study was to identify changes in presentation, treatment and outcomes of older patients with low-grade glioma (LGG) over the past 50 years. 94 adults aged 55 or older upon diagnosis of a WHO grade II LGG at Mayo Clinic between 1960 and 2011 were included and grouped by those diagnosed before (group I: 1960-1989) and after (group II: 1990-2011) the routine use of post-operative MRI. Median follow-up was 11.4 years. Pathologic diagnoses included astrocytoma in 55%, mixed oligoastrocytoma in 18% and oligodendroglioma in 27%...
April 21, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28431670/use-of-glp-1-receptor-agonists-for-type-2-diabetes-treatment-intensification-after-basal-insulin-failure
#18
M Joubert, Y Reznik
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are part of the armamentarium for the treatment of type 2 diabetes (T2D), although recent guidelines have mainly recommended their use on top of oral treatments when a single or combination of two or three oral hypoglycaemic agents has failed to lower HbA1c levels below the individualized target range. In such situations, the decision to use GLP-1RAs is mostly driven by their high level of efficacy, their effect on body weight balance and their safety considerations, such as low hypoglycaemic risk...
April 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28395938/perceptions-of-general-practitioners-on-initiation-and-intensification-of-type-2-diabetes-injectable-therapies-a-quantitative-study-in-the-united-kingdom
#19
Daniel Sterzi, Sébastien Auziere, Divina Glah, Marie Markert Jensen
Most diabetes care is done by general practitioners (GPs) in the UK. This study aimed to determine GPs' comfort level in initiating and intensifying injectable therapies, identifying any associated barriers, and assessing reasons for referral to specialists. This web-interview included 128 general practitioners (GPs) experienced in type 2 diabetes (T2D) management, as well as 57 specialists and 30 nurses who were studied for secondary objectives. GPs felt more comfortable initiating the 1st injectable therapy - typically the glucagon-like peptide-1 receptor agonists (GLP-1 RA) - than the 2nd...
June 2017: Primary Care Diabetes
https://www.readbyqxmd.com/read/28391549/disease-burden-of-mild-asthma-findings-from-a-cross-sectional-real-world-survey
#20
Bo Ding, Mark Small
INTRODUCTION: Most asthma patients have mild disease, although the burden of mild asthma is not well understood nor studied. Some evidence suggests that many patients with mild asthma experience suboptimal symptom control and exacerbations. This study characterizes the burden of illness and treatment patterns among patients with a confirmed diagnosis of mild asthma, defined as GINA Step 1 or Step 2, and residing in China, France, Germany, Italy, Japan, Spain, the United Kingdom, or the United States...
May 2017: Advances in Therapy
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