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PET-CT endocarditis

Nidaa Mikail, Khadija Benali, Besma Mahida, Jonathan Vigne, Fabien Hyafil, François Rouzet, Dominique Le Guludec
PURPOSE OF REVIEW: This review analyzes recent studies evaluating the diagnostic value of18 F-FDG-PET/CT for the detection of peripheral emboli and secondary infectious foci in patients with infective endocarditis and cardiac device infections. RECENT FINDINGS: Detection of extracardiac septic localizations in patients with infective endocarditis and cardiac device infections is crucial, as it may impact the diagnosis, prognosis, and therapeutic management. Recent literature substantiated the clinical usefulness of18 F-FDG-PET/CT in this setting...
March 6, 2018: Current Cardiology Reports
S Aguadé Bruix, A Roque Pérez, H Cuéllar Calabria, M N Pizzi
Infective endocarditis (IE) is a serious pathology with a poor prognosis, whose mortality has not changed significantly despite advances in its diagnosis and treatment in the last 30years. The diagnostic capacity of the modified Duke criteria in prosthetic endocarditis and/or devices does not exceed 50%, so new tools are necessary for the diagnosis of this entity in this context. The18 F-FDG PET/CTA combines a highly sensitive technique to detect inflammatory-infectious activity and a technique with high anatomical resolution to assess the structural lesions associated with endocarditis...
February 26, 2018: Revista Española de Medicina Nuclear e Imagen Molecular
Daniel García-Arribas, Isidre Vilacosta, Aida Ortega Candil, Cristina Rodríguez Rey, Carmen Olmos, María Jesús Pérez Castejón, David Vivas, Carlos Nicolás Pérez-García, Manuel Carnero-Alcázar, Cristina Fernández-Pérez, Luis Maroto, José Luis Carreras
OBJECTIVE: Infection of valved aortic grafts is a rare entity whose diagnosis remains challenging. Positron emission tomography (PET)/CT has become a criterion for the diagnosis of infective endocarditis (IE) in prosthetic valves, but its role on ascending aortic graft infections remains unclear. This study aims to assess the diagnostic value of PET/CT in patients with valved aortic graft infection. METHODS: 12 episodes with a valved aortic graft who had undergone a PET/CT due to suspicion of IE were prospectively included (group I) and compared with five controls free of infection who underwent PET/CT for other reasons (group II)...
February 22, 2018: Heart: Official Journal of the British Cardiac Society
Laurens E Swart, Asbjørn M Scholtens, Wilco Tanis, Koen Nieman, Ad J J C Bogers, Fred J Verzijlbergen, Gabriel P Krestin, Jolien W Roos-Hesselink, Ricardo P J Budde
The timely diagnosis of prosthetic heart valve endocarditis remains challenging yet of utmost importance. 18F-fluorodeoxyglucose (18 F-FDG) positron emission/computed tomography (PET/CT) and cardiac computed tomography angiography (CTA) were recently introduced as additional diagnostic tools in the most recent ESC guidelines on infective endocarditis. However, how to interpret PET/CT findings with regard to what is to be considered abnormal, what the potential confounders may be, as well as which patients benefit most from these additional imaging techniques and how to best perform them in these often-complex patients, remains unclear...
January 16, 2018: European Heart Journal
Ümit Yaşar Sinan, Burcu Dirlik Serim, Rukiye Yıldırım, Özge Çetinarslan, Mehmet Serdar Küçükoğlu
Infective endocarditis (IE) is an infectious disease that affects the endothelium of the large intrathoracic vessels, heart valves, and intra-cardiac foreign body material. A 20-year-old woman was admitted to the cardiology department with complaints of fever and palpitations. Transthoracic echocardiography revealed a bicuspid aortic valve, aortic root enlargement, and aortic coarctation. Transesophageal echocardiography revealed a bicuspid aortic valve, but there was no vegetation. Methicillin-sensitive Staphylococcus aureus was identified on a blood culture...
January 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
Anne Christine Nordholm, Ruth Ottilia Birgitta Vøgg, Henrik Permin, Terese Katzenstein
BACKGROUND: Eikenella corrodens is one of the HACEK bacteria constituting part of the normal flora of the oropharynx, however, still an uncommon pathogen. We report a case of a large Eikenella corrodens liver abscess with simultaneously endocarditis in a previously healthy male. CASE PRESENTATION: A 49-year-old Danish man was admitted because of one-month malaise, fever, cough and unintentional weight loss. On admission there was elevated white blood cell count and C-reactive protein, as well as affected liver function tests...
January 12, 2018: BMC Infectious Diseases
Jelena Šaponjski, Dragana Šobić-Šaranović, Strahinja Odalović, Milica Stojiljković, Jelena Pantović, Nebojša Petrović, Isidora Grozdić-Milojević, Vera Artiko
INTRODUCTION: Positron emission tomography with computed tomography (18F-FDG PET/CT) is a nuclear medicine diagnostic method which, unlike other technological modalities that asses anatomical features, detects increased glucose metabolism inside the cells, thus is very helpful in diagnosing cardiovascular infection and inflammation and also in therapy planning. AIM: Aim of this study was to assess the significance of 18F-FDG PET/CT in detection of an active disease in patients with infection and inflammation of cardiovascular system...
September 2017: Hellenic Journal of Nuclear Medicine
Asbjørn M Scholtens, Hein J Verberne
No abstract text is available yet for this article.
January 10, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Martina Sollini, Chiara Lauri, Roberto Boni, Elena Lazzeri, Paola Anna Erba, Alberto Signore
There is an increased need to find non-invasive tools for early diagnosis and follow-up of infections. Nuclear medicine techniques may be used to diagnose, localize and evaluate the severity and the extent of infections before the occurrence of anatomical abnormalities. This review focuses on different approaches based on radiolabelled cells, peptides and antibodies or [18F]FDG to image infective diseases in agreement with what is being jointly evaluated by the European Association of Nuclear Medicine (EANM)...
January 9, 2018: Current Pharmaceutical Design
Maria Bonou, Chris J Kapelios, Michael Samarkos, George Benetos, Maria Tampaki, Nikoletta Pianou, Alexandros Georgakopoulos, Ioannis Moyssakis, Constantinos Anagnostopoulos, John Barbetseas
No abstract text is available yet for this article.
December 22, 2017: International Journal of Infectious Diseases: IJID
Jean-François Sarrazin, Mikaël Trottier, Michel Tessier
No abstract text is available yet for this article.
November 15, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Daniel Juneau, Mohammad Golfam, Samir Hazra, Fernanda Erthal, Lionel S Zuckier, Jordan Bernick, George A Wells, Rob S B Beanlands, Benjamin J W Chow
BACKGROUND: Infective endocarditis (IE) is a serious, potentially life-threatening condition. Currently, the modified Duke criteria is used to assist with the diagnosis of IE, but it can still remain difficult. Growing data supports the potential use of molecular imaging to assist in the diagnosis of IE. Our objective was to understand the potential utility of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography-computed tomography (PET-CT), 67Ga citrate and radiolabeled white blood cell (WBC) scintigraphy in the diagnosis of IE...
November 8, 2017: International Journal of Cardiology
Inbar Nardi Agmon, Elad Goldberg, Eytan Cohen, Ilan Krause
The potent immunosuppressive drugs used by transplant recipients place them at risk of infections. Data on infective endocarditis (IE) in the setting of renal transplantation (RT) are sparse. We describe a 36-year-old woman referred to a tertiary medical center for evaluation of elevated creatinine levels 1 month after a second RT. Work-up revealed the presence of all four of Duke's criteria: fever, persistent bacteremia, new-onset tricuspid regurgitation, and masses suspected to be vegetation attached to the tricuspid annulus...
December 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
María N Pizzi, L Dos-Subirà, Albert Roque, Nuria Fernández-Hidalgo, Hug Cuéllar-Calabria, Antonia Pijuan Domènech, María T Gonzàlez-Alujas, M T Subirana-Domènech, B Miranda-Barrio, Ignacio Ferreira-González, Juan J González-López, Albert Igual, Olga Maisterra-Santos, David García-Dorado, Joan Castell-Conesa, Benito Almirante, Manuel Escobar Amores, Pilar Tornos, Santiago Aguadé-Bruix
OBJECTIVES: Infective endocarditis (IE) and cardiac device infection (CDI) are a major complication in the growing number of patients with congenital heart disease (CHD) reaching adulthood. We aimed to evaluate the added value of (18)F-FDG-PET/CT angiography (PET/CTA) in the diagnosis of IE-CDI in adults with CHD and intravascular or intracardiac prosthetic material, in whom echocardiography (ECHO) and modified Duke Criteria (DC) have limitations because of the patients' complex anatomy...
December 1, 2017: International Journal of Cardiology
Bernd Salzberger, Gabriele Birkenfeld, Michael Iberer, Florian Hitzenbichler
Fever of unexplained (or unknown) origin (FUO) remains a relevant clinical problem even with modern diagnostic methods. In addition to the classical definition, new categories of FUO describe different clinical situations: nosocomial FUO, FUO in neutropenic/immundeficient patients and FUO in patients with HIV-infection. The new categories are defined by much shorter duration of fever, i. e. mostly three days. Each category of FUO shows a different spectrum of infectious diseases. Often, subacute bacterial endocarditis is very difficult to verify...
July 2017: Deutsche Medizinische Wochenschrift
Thomas H Schindler
No abstract text is available yet for this article.
June 5, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Asbjørn M Scholtens, Laurens E Swart, Henryk J Te Kolste, Ricardo P J Budde, Marnix G E H Lam, Hein J Verberne
BACKGROUND: The significance of and threshold values for the standardized uptake value (SUV) in FDG PET/CT to diagnose prosthetic heart valve (PHV) endocarditis (PVE) are unclear at present. METHODS: A literature search was performed in the PubMed and EMBASE medical databases, comprising the following terms: (FDG OR *fluorode* OR *fluoro-de*) AND (endocarditis OR prosthetic heart valve OR valve replacement). Studies reporting SUVs correlated to the diagnosis of PVE were selected for analysis...
June 5, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
A M Scholtens, R P J Budde, M G E H Lam, H J Verberne
No abstract text is available yet for this article.
October 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Carine Boulon, Noëlle Bernard, Fabrice Bonnet, Joël Constans
(18)Fluoro-desoxy-glucose positron-emission tomography (F-FDG-PET) may be useful to diagnose complications of endocarditis in difficult cases. We report the case of a young patient who had endocarditis and a painful leg. FDG PET/computed tomography showed hypermetabolism in the leg, and duplex ultrasound suggested an inflammatory aneurysm at the site of the hypermetabolism. The combination of FDG-PET/computed tomography and duplex ultrasound is useful to diagnose mycotic aneurysm in the setting of bacterial endocarditis...
May 24, 2017: Annals of Vascular Surgery
Ilse J E Kouijzer, Linda M Kampschreur, Peter C Wever, Corneline Hoekstra, Marjo E E van Kasteren, Monique G L de Jager-Leclercq, Marrigje H Nabuurs-Franssen, Marjolijn C A Wegdam-Blans, Heidi S M Ammerlaan, Jacqueline Buijs, Lioe-Fee de Geus-Oei, Wim J G Oyen, Chantal P Bleeker-Rovers
In 1%-5% of all acute Q fever infections, chronic Q fever develops, mostly manifesting as endocarditis, infected aneurysms, or infected vascular prostheses. In this study, we investigated the diagnostic value of18 F-FDG PET/CT in chronic Q fever at diagnosis and during follow-up. Methods: All adult Dutch patients suspected of chronic Q fever who were diagnosed since 2007 were retrospectively included until March 2015, when at least one18 F-FDG PET/CT scan was obtained. Clinical data and results from18 F-FDG PET/CT at diagnosis and during follow-up were collected...
January 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
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