keyword
https://read.qxmd.com/read/38492601/the-impact-of-global-climate-changes-on-trace-and-rare-earth-elements-mobilization-in-emerging-periglacial-terrains-insights-from-western-shore-of-admiralty-bay-king-george-island-antarctic
#21
JOURNAL ARTICLE
Andrzej R Reindl, Lidia Wolska, Agnieszka I Piotrowicz-Cieślak, Dominika Saniewska, Jerzy Bołałek, Michał Saniewski
In the rapidly changing climate, the biogeochemical behaviours of trace elements and Rare Earth Elements (REEs) in emerging periglacial environments assumes profound importance. This study provides pivotal insights into this dynamic by investigating the Antarctic's response to global climate change. The bedrock of King George Island is rich in REEs, with the presence of trace metals (TEs), with the highest concentrations of metals found in ornithogenic soil (∑REE 84.01-85.53 mg∙kg-1 dry weight)...
March 14, 2024: Science of the Total Environment
https://read.qxmd.com/read/38492534/comprehensive-analysis-of-transcription-factor-based-molecular-subtypes-and-their-correlation-to-clinical-outcomes-in-small-cell-lung-cancer
#22
JOURNAL ARTICLE
Sehhoon Park, Tae Hee Hong, Soohyun Hwang, Simon Heeke, Carl M Gay, Jiyeon Kim, Hyun-Ae Jung, Jong-Mu Sun, Jin Seok Ahn, Myung-Ju Ahn, Jong Ho Cho, Yong Soo Choi, Jhingook Kim, Young Mog Shim, Hong Kwan Kim, Lauren Averett Byers, John V Heymach, Yoon-La Choi, Se-Hoon Lee, Keunchil Park
BACKGROUND: Recent studies have reported the predictive and prognostic value of novel transcriptional factor-based molecular subtypes in small-cell lung cancer (SCLC). We conducted an in-depth analysis pairing multi-omics data with immunohistochemistry (IHC) to elucidate the underlying characteristics associated with differences in clinical outcomes between subtypes. METHODS: IHC (n = 252), target exome sequencing (n = 422), and whole transcriptome sequencing (WTS, n = 189) data generated from 427 patients (86...
March 15, 2024: EBioMedicine
https://read.qxmd.com/read/38492503/sink-source-connectivity-for-restocking-of-pinna-nobilis-in-the-western-mediterranean-sea
#23
JOURNAL ARTICLE
A Feria-Rodríguez, D March, B Mourre, I E Hendriks, M Vázquez-Luis
The critically endangered endemic bivalve Pinna nobilis from the Mediterranean Sea suffered a sudden population decline after a mass mortality event in early autumn 2016. Conservation efforts aimed at preventing extinction included safeguarding resistant individuals and implementing a breeding plan to contribute to the repopulation of the species. This study utilized a model combining Lagrangian dispersion and connectivity analyses to pinpoint optimal restocking sites in the Western Mediterranean. Our approach allowed to identify locations capable of sustaining and generating larvae for broader repopulation in key areas of the Western Mediterranean Sea prior to the mass mortality event...
March 11, 2024: Marine Environmental Research
https://read.qxmd.com/read/38492496/effects-of-radiofrequency-electromagnetic-field-rf-emf-exposure-on-male-fertility-a-systematic-review-of-experimental-studies-on-non-human-mammals-and-human-sperm-in-vitro
#24
JOURNAL ARTICLE
Eugenia Cordelli, Lucia Ardoino, Barbara Benassi, Claudia Consales, Patrizia Eleuteri, Carmela Marino, Maurizio Sciortino, Paola Villani, Martin H Brinkworth, Guangdi Chen, James P McNamee, Andrew W Wood, Lea Belackova, Jos Verbeek, Francesca Pacchierotti
BACKGROUND: The World Health Organization is coordinating an international project aimed at systematically reviewing the evidence regarding the association between radiofrequency electromagnetic field (RF-EMF) exposure and adverse health effects. Reproductive health outcomes have been identified among the priority topics to be addressed. OBJECTIVES: To evaluate the effect of RF-EMF exposure on male fertility of experimental mammals and on human sperm exposed in vitro...
February 19, 2024: Environment International
https://read.qxmd.com/read/38492457/how-clspn-could-demystify-its-prognostic-value-and-potential-molecular-mechanism-for-hepatocellular-carcinoma-a-crosstalk-study
#25
JOURNAL ARTICLE
Yanlong Shi, Yizhu Wang, Kaiyi Niu, Wenning Zhang, Qingpeng Lv, Yewei Zhang
BACKGROUND & AIMS: CLSPN, a critical component of the S-phase checkpoint in response to DNA replication stress, has been implicated in the pathogenesis of multiple tumor types. The rising incidence of hepatocellular carcinoma (HCC) poses a significant challenge to global public health. Despite this, the specific functions of CLSPN in the development of HCC remain poorly understood. METHODS: We systematically evaluated the expression of CLSPN, prognosis and immune infiltration in patients with HCC and identified a competing endogenous RNA (ceRNA) network by using public database...
March 11, 2024: Computers in Biology and Medicine
https://read.qxmd.com/read/38492330/alcohol-industry-sponsored-music-festivals-alcohol-marketing-and-drinking-practices-among-young-nigerians-implications-for-policy
#26
JOURNAL ARTICLE
Emeka W Dumbili
INTRODUCTION: The global alcohol industry sponsors social/music events targeting young people; however, existing literature focuses on Westernised contexts. Given the decline in young people's drinking in many Western countries, it appears that multinational alcohol companies are importing the strategies they have used in high-income countries to the Global South countries like Nigeria to recoup profits. This study aims to examine the Guinness Show- a free one-month annual music festival, alcohol marketing at the festival and the extent to which the event encourages diverse drinking practices among its attendees...
March 15, 2024: International Journal on Drug Policy
https://read.qxmd.com/read/38492245/peptide-om-lv20-promotes-arteriogenesis-induced-by-femoral-artery-ligature-via-the-mir-29b-3p-vegfa-axis
#27
JOURNAL ARTICLE
Yingxuan Zhang, Zijian Kang, Jianjun Wang, Sahua Liu, Xin Liu, Zhiruo Li, Yilin Li, Yinglei Wang, Zhe Fu, Jiayi Li, Yubing Huang, Zeqiong Ru, Ying Peng, Zhiyu Yang, Ying Wang, Xinwang Yang, Mingying Luo
BACKGROUND AND AIMS: Therapeutic arteriogenesis is a promising direction for the treatment of ischemic disease caused by atherosclerosis. However, pharmacological or biological approaches to stimulate functional collateral vessels are not yet available. Identifying new drug targets to promote and explore the underlying mechanisms for therapeutic arteriogenesis is necessary. METHODS: Peptide OM-LV20 (20 ng/kg) was administered for 7 consecutive days on rat hindlimb ischemia model, collateral vessel growth was assessed by H&E staining, liquid latex perfusion, and specific immunofluorescence...
February 28, 2024: Atherosclerosis
https://read.qxmd.com/read/38492244/systemic-loss-of-cd36-aggravates-nafld-related-hcc-through-mek1-2-erk1-2-signaling-pathway
#28
JOURNAL ARTICLE
Enze Zheng, Qianqian Chen, Anhua Xiao, Xiaoqing Luo, Qiannan Lu, Chuan Tian, Huan Liu, Jinqing Zhao, Li Wei, Ping Yang, Yaxi Chen
BACKGROUND & AIMS: CD36, a membrane protein widely present in various tissues, is crucial role in regulating energy metabolism. The rise of HCC as a notable outcome of NAFLD is becoming more apparent. Patients with hereditary CD36 deficiency are at increased risk of NAFLD. However, the impact of CD36 deficiency on NAFLD-HCC remains unclear. METHODS: Global CD36 knockout mice (CD36KO) and wild type mice (WT) were induced to establish NAFLD-HCC model by N-nitrosodiethylamine (DEN) plus high fat diet (HFD)...
March 12, 2024: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/38492198/characteristics-of-chronic-lymphocytic-leukemia-in-japan-comprehensive-analysis-of-the-cllrsg-01-study
#29
JOURNAL ARTICLE
Jun Takizawa, Ritsuro Suzuki, Koji Izutsu, Toru Kiguchi, Hideki Asaoku, Yoshio Saburi, Taro Masunari, Atae Utsunomiya, Kengo Takeuchi, Naoya Nakamura, Koichi Ohshima, Michaela Gruber, Ulrich Jäger, Sadao Aoki, Junji Suzumiya
Chronic lymphocytic leukemia (CLL) is rare in Japan. We conducted the nationwide, prospective observational study CLLRSG-01 to clarify the current state of CLL in Japan and to make accurate international comparisons by preparing naturally air-dried smears like those used in other countries. Of the 201 untreated patients enrolled and evaluated, 119 were diagnosed with CLL and 82 with non-CLL mature B-cell neoplasms, based on the WHO classification. Of the 119 CLL patients, 90 were classified as typical and 29 as atypical according to FAB classification morphology, with the proportion of atypical CLL consistent with reports from other countries...
March 16, 2024: International Journal of Hematology
https://read.qxmd.com/read/38492186/immunomodulatory-and-anti-inflammatory-effects-of-vitamin-a-and-tryptophan-on-monocyte-derived-dendritic-cells-stimulated-with-gliadin-in-celiac-disease-patients
#30
JOURNAL ARTICLE
Fatemeh Asgari, Abdolrahim Nikzamir, Kaveh Baghaei, Siamak Salami, Andrea Masotti, Mohammad Rostami-Nejad
Celiac Disease (CeD) is an autoimmune disorder with various symptoms upon gluten exposure. Dendritic cells (DCs) play a crucial role in gliadin-induced inflammation. Vitamin A (retinol; Ret) and its metabolite, retinoic acid (RA), along with tryptophan (Trp) and its metabolite, kynurenic acid (KYNA), are known to influence the immune function of DCs and enhance their tolerogenicity. This research aims to assess the impact of gliadin on DC maturation and the potential of vitamin A and tryptophan to induce immune tolerance in DCs...
March 16, 2024: Inflammation
https://read.qxmd.com/read/38492155/extraction-and-identification-of-exosomes-from-three-different-sources-of-human-ovarian-granulosa-cells-and-analysis-of-their-differential-mirna-expression-profiles
#31
JOURNAL ARTICLE
Xiaorong Li, Ting Gao, Xiaohong Ma, Jiawen Zhong, Ling Qin, Yan Nian, Xueyi Wang, Yuxue Luo
OBJECTIVE: As important functional cells in the ovary, ovarian granulosa cells are involved in the regulation of oocyte growth and development and play an important role in the study of female fertility preservation. Based on the importance of granulosa cell functionalism, in this study, we analyzed the exosome secretion capacity of human ovarian granulosa cells (SVOG/KGN-cell line, PGC-primary cells) and the differences in their miRNA expression. METHODS: Cells were identified by hematoxylin-eosin staining (HE) and FSHR immunofluorescence staining; CCK8 and colony-forming assay were performed to compare cell proliferation capacity; exosomes were extracted and identified by ultra-high speed centrifugation, transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), and western blot analysis (WB), and the expression profile of each cellular exosomal miRNA was analyzed by miRNA high-throughput sequencing...
March 16, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38492140/species-distribution-modeling-combined-with-environmental-dna-analysis-to-explore-distribution-of-invasive-alien-mosquitofish-gambusia-affinis-in-china
#32
JOURNAL ARTICLE
Xu Han, Jinxiao Chen, Lang Wu, Guo Zhang, Xiaoteng Fan, Tao Yan, Long Zhu, Yongjing Guan, Linjun Zhou, Tingting Hou, Xue Xue, Xiangju Li, Mingrong Wang, Haoran Xing, Xiaofan Xiong, Zaizhao Wang
China has become one of the most serious countries suffering from biological invasions in the world. In the context of global climate change, invasive alien species (IAS) are likely to invade a wider area, posing greater ecological and economic threats in China. Western mosquitofish (Gambusia affinis), which is known as one of the 100 most invasive alien species, has distributed widely in southern China and is gradually spreading to the north, causing serious ecological damage and economic losses. However, its distribution in China is still unclear...
March 16, 2024: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38492137/assessment-of-microplastic-contamination-in-some-commercial-fishes-of-the-southern-caspian-sea-and-its-potential-risks
#33
JOURNAL ARTICLE
Mohammad Gholizadeh, Tahereh Bagheri, Mohammad Harsij, Durali Danabas, Mohammad Zakeri, Mohammad Abdul Momin Siddique
This study examined the occurrence of microplastics (MPs) in the gastrointestinal tract (GIT) of 384 fishes classified into four species from 11 sites in 2022 from the southern part of the Caspian Sea. GITs of fishes were collected and digested in H2 O2 and KOH at 45 °C for 72 h. After filtration, extracted MPs were observed under a stereomicroscope, and selected MP particles were identified using FTIR. Presence of MPs was 68.98% in the GIT of the investigated fish. The mean abundance of MPs was 5...
March 16, 2024: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38492123/the-mechanism-of-lncrna-malat1-targeting-the-mir-124-3p-igf2bp1-axis-to-regulate-osteogenic-differentiation-of-periodontal-ligament-stem-cells
#34
JOURNAL ARTICLE
Nan Gu, Yao Wang, Lingfeng Li, Xin Sui, Zhihui Liu
OBJECTIVES: This study aimed to investigate the regulatory roles of lncRNA MALAT1, miR-124-3p, and IGF2BP1 in osteogenic differentiation of periodontal ligament stem cells (PDLSCs). MATERIALS AND METHODS: We characterized PDLSCs by employing quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot analyses to evaluate the expression of key osteogenic markers including ALPL, SPP1, and RUNX2. Manipulation of lncRNA MALAT1 and miR-124-3p expression levels was achieved through transfection techniques...
March 16, 2024: Clinical Oral Investigations
https://read.qxmd.com/read/38492062/relationship-between-increased-knee-joint-line-obliquity-after-medial-open-wedge-high-tibial-osteotomy-and-patient-reported-outcome-measures
#35
JOURNAL ARTICLE
Kazushi Horita, Shinichiro Okimura, Kodai Hamaoka, Yasutoshi Ikeda, Yohei Okada, Tomoaki Kamiya, Tomoyuki Suzuki, Atsushi Teramoto
INTRODUCTION: This study evaluated the correlation between postoperative knee joint line obliquity after medial open-wedge high tibial osteotomy and patient-reported outcome measures excluding excessively overcorrected knees. This study further identified preoperative radiological factors related to the increased postoperative knee joint line obliquity. MATERIALS AND METHODS: We retrospectively evaluated patients who underwent medial open-wedge high tibial osteotomy between March 2013 and March 2021...
March 16, 2024: Archives of Orthopaedic and Trauma Surgery
https://read.qxmd.com/read/38492053/dexamethasone-relieves-the-inflammatory-response-caused-by-inguinal-hernia-meshes-through-mir-155
#36
JOURNAL ARTICLE
Y Li, Y Lv, J Li, P Ling, X Guo, L Zhang, J Ni, Y Long
BACKGROUND: Inguinal hernia is a relatively common condition. Most patients with inguinal hernia require surgery. At present, mesh repair is one of the most effective methods to treat inguinal hernia, but insertion of the mesh can cause inflammation. Dexamethasone (DEX) can treat inflammation, but the mechanism by which DEX alleviates inflammation caused by inguinal hernia mesh placement remains unclear. METHOD: We randomly divided rats into groups: negative control (NC), inguinal hernia (IH), polypropylene mesh (PM), DEX treatment, and miR-155 treatment groups...
March 16, 2024: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://read.qxmd.com/read/38492047/the-effect-of-balance-exercises-on-central-sensitization-in-patients-with-knee-osteoarthritis
#37
JOURNAL ARTICLE
Emre Tirasci, Tunay Sarpel, Ilke Coskun Benlidayi, Volkan Deniz
The aim of this study was to evaluate the effectiveness of balance exercises on functional status, pain, balance, and central sensitization in patients with knee osteoarthritis (OA). Patients diagnosed with bilateral Kellgren-Lawrence grade ≥ 2 primary knee OA and associated central sensitization were included in the study. Patients were randomized into two groups. Both groups were provided with verbal and written information on knee OA. In addition, the intervention group received a supervised balance exercise program for 6 weeks, 3 days a week on alternating days...
March 16, 2024: Rheumatology International
https://read.qxmd.com/read/38491988/a-story-of-in-coherence-climate-adaptation-for-health-in-south-african-policies
#38
JOURNAL ARTICLE
Amanda V Quintana, Susannah H Mayhew, Sari Kovats, Lucy Gilson
Climate adaptation strengthens and builds the resilience of health systems to future climate-related shocks. Adaptation strategies and policies are necessary tools for governments to address the long-term impacts of climate change and enable the health system to respond to current impacts such as extreme weather events. Since 2011 South Africa has national climate change policies and adaptation strategies, yet there is uncertainty about: how these policies and plans are executed; the extent to which health policies include adaptation; and the extent of policy coherence across sectors and governance levels...
February 28, 2024: Health Policy and Planning
https://read.qxmd.com/read/38491972/platycodin-d-ameliorates-cognitive-impairment-in-type-2-diabetes-mellitus-mice-via-regulating-pi3k-akt-gsk3%C3%AE-signaling-pathway
#39
JOURNAL ARTICLE
Ya-Wei Lu, Li-Ya Xie, Meng-Han Qi, Shen Ren, Yue-Qi Wang, Jun-Nan Hu, Zi Wang, Shan Tang, Jing-Tian Zhang, Wei Li
Objectives: The aim of this study was to investigate the ameliorative effect of platycodin D (PD) on cognitive dysfunction in type 2 diabetes mellitus (T2DM) and its potential molecular mechanisms of action in vivo and in vitro. Materials and methods: An animal model of cognitive impairment in T2DM was established using a single intraperitoneal injection of streptozotocin (100 mg/kg) after 8 weeks of feeding a high-fat diet to C57BL/6 mice. In vitro, immunofluorescence staining and Western blot were employed to analyze the effects of PD on glucose-induced neurotoxicity in mouse hippocampal neuronal cells (HT22)...
March 16, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38491852/metabolomics-based-effects-of-a-natural-product-on-remyelination-after-cerebral-ischemia-injury-via-gababr-pcreb-bdnf-pathway
#40
JOURNAL ARTICLE
Xiaodi Fan, Min Zhan, Wenting Song, Mingjiang Yao, Guangrui Wang, Tian Li, Yehao Zhang, Jianxun Liu
BACKGROUND: Yi-Qi-Tong-Luo Granules (YQTLs) is a natural compound of Traditional Chinese Medicine authorized by China Food and Drug Administration (CFDA). These granules are employed in the convalescent stage of cerebral infarction and render notable clinical efficacy. This study aims to uncover the underlying mechanisms of YQTLs on remyelination after cerebral ischemia injury. MATERIALS AND METHODS: We established cerebral ischemia model in rats using microsphere-induced multiple cerebral infarction (MCI)...
March 16, 2024: Neurorehabilitation and Neural Repair
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