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https://www.readbyqxmd.com/read/28235248/inhibition-of-shedding-of-low-density-lipoprotein-receptor-related-protein-1-reverses-cartilage-matrix-degradation-in-osteoarthritis
#1
Kazuhiro Yamamoto, Salvatore Santamaria, Kenneth A Botkjaer, Jayesh Dudhia, Linda Troeberg, Yoshifumi Itoh, Gillian Murphy, Hideaki Nagase
OBJECTIVES: The aggrecanase ADAMTS-5 and the collagenase MMP-13 are constitutively secreted by chondrocytes in normal cartilage, but rapidly endocytosed via the cell surface endocytic receptor low-density lipoprotein receptor-related protein 1 (LRP1) and subsequently degraded. This endocytic system is impaired in osteoarthritic (OA) cartilage due to increased ectodomain 'shedding' of LRP1. The aim of this study is to identify the LRP1 sheddase(s) in human cartilage, and to test whether inhibition of LRP1 shedding prevents the cartilage degradation in OA...
February 24, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28235183/diversity-of-nodular-bacteria-of-scorpiurus-muricatus-in-western-algeria-and-their-impact-on-plant-growth
#2
Zoulikha Bouchiba, Zineb Faiza Boukhatem, Zohra Ighilhariz, Nouria Derkaoui, Benaissa Kerdouh, Hanaa Abdelmoumen, Younes Abbas, Mustapha Missbah El Idrissi, Abdelkader Bekki
A total of 51 bacterial strains were isolated from root nodules of Scorpiurus muricatus sampled from six regions of western Algeria. Strains diversity was assessed by rep-PCR amplification fingerprinting which had allowed grouping the isolates into 28 different clusters. Partial Nucleotide sequencing of 16SrRNA gene and BLAST analysis revealed that root nodules of Scorpiurus muricatus were colonized by different species close to Rhizobium vignae, Rhizobium radiobacter, Rhizobium leguminosarum, Phyllobacterium ifriquiensis, Phyllobacterium endophyticum, Starkeya sp...
February 24, 2017: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/28235145/cardiac-transplantation-in-a-neonate-first-case-in-switzerland-and-european-overview
#3
Martin Schweiger, Brian Stiasny, F Immer, Christoph Bürki, M Schmiady, Hitendu Dave, Anna Cavigelli-Brunner, Oliver Kretschmar, Vincenzo Cannizzaro, Michael Hübler
Twenty-four percent of pediatric heart transplantations (pHTx) are carried out in infants. Neonatal heart transplantation is both rarely performed and challenging. We report on a newborn baby girl suffering from cardiac failure due to a huge tumor (24x52 mm) within the free wall of the left ventricle (LV) and subtotal obstruction of the main left bronchus. Following a surgical tumor resection, a Berlin Heart EXCOR left ventricular assist device was implanted as the bridge to the transplantation. In spite of an organ donor/recipient mismatch of >200%, both heart transplantation and the post-operative course were successful...
February 24, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28235135/allergenome-characterization-of-the-mosquito-aedes-aegypti
#4
J F Cantillo, L Puerta, P Puchalska, S Lafosse-Marin, J L Subiza, E Fernández-Caldas
BACKGROUND: Saliva and muscle derived mosquito allergens have been purified and characterized. However, the complete set of allergens remains to be elucidated. In this study, we identified and characterized IgE-binding proteins from the mosquito species A. aegypti. METHODS: Serum was obtained from 15 allergic individuals with asthma and/or rhinitis and sensitized to mosquito. IgE-binding was determined by ELISA. Total proteins from freeze dried bodies of A. aegypti were extracted and IgE reactive proteins were identified by 2D-gel electrophoresis, followed by Western blot with pooled or individual sera...
February 24, 2017: Allergy
https://www.readbyqxmd.com/read/28235105/correction-prevalence-of-dyslipidaemia-and-associated-risk-factors-in-a-rural-population-in-south-western-uganda-a-community-based-survey
#5
Gershim Asiki, Georgina A V Murphy, Kathy Baisley, Rebecca N Nsubuga, Dermot Maher, Alex Karabarinde, Robert Newton, Janet Seeley, Elizabeth H Young, Anatoli Kamali, Manjinder S Sandhu
[This corrects the article DOI: 10.1371/journal.pone.0126166.].
2017: PloS One
https://www.readbyqxmd.com/read/28235100/phase-specific-expression-of-an-insulin-like-androgenic-gland-factor-in-a-marine-shrimp-lysmata-wurdemanni-implication-for-maintaining-protandric-simultaneous-hermaphroditism
#6
Dong Zhang, Min Sun, Xin Liu
BACKGROUND: Shrimp in the genus Lysmata have a unique and rare sexual system referred to as protandric simultaneous hermaphroditism, whereby individuals mature first as male (male phase), and then the female function may also develop as the shrimp grow, so that the gonad is able to produce both eggs and sperms simultaneously, a condition called simultaneous hermaphroditism (euhermaphrodite phase). To date, the mechanisms of sex control in this sexual system still remain poorly understood...
2017: PloS One
https://www.readbyqxmd.com/read/28235037/canstatin-inhibits-hypoxia-induced-apoptosis-through-activation-of-integrin-focal-adhesion-kinase-akt-signaling-pathway-in-h9c2-cardiomyoblasts
#7
Hiroki Kanazawa, Keisuke Imoto, Muneyoshi Okada, Hideyuki Yamawaki
A hypoxic stress which causes apoptosis of cardiomyocytes is the main problem in the ischemic heart disease. Canstatin, a non-collagenous fragment of type IV collagen α2 chain, is an endogenous anti-angiogenic factor. We have previously reported that canstatin has a cytoprotective effect on cardiomyoblasts. In the present study, we examined the effects of canstatin on hypoxia-induced apoptosis in H9c2 cardiomyoblasts. Cell counting assay was performed to determine a cell viability. Western blotting was performed to detect expression of cleaved casepase-3 and phosphorylation of focal adhesion kinase (FAK) and Akt...
2017: PloS One
https://www.readbyqxmd.com/read/28235033/post-breeding-movements-of-ancient-murrelet-synthliboramphus-antiquus-family-groups-subsequent-migration-of-adults-and-implications-for-management
#8
Anthony J Gaston, Yuriko Hashimoto, Laurie Wilson
Increased shipping in British Columbia (BC) waters poses risks for marine birds from marine oil spills. Ancient Murrelets (Synthliboramphus antiquus), small marine diving birds of which half of the world's population breeds in BC, are especially susceptible to oiling immediately after departing from their breeding colonies, as their offspring are flightless, constraining their parents to remain with them. In 2014 we deployed geolocator loggers on Ancient Murrelets at four breeding colonies, two on the east and two on the west coast of Haida Gwaii to investigate patterns of post-breeding dispersal and subsequent migratory movements...
2017: PloS One
https://www.readbyqxmd.com/read/28235025/mitochondrial-dna-analysis-of-eneolithic-trypillians-from-ukraine-reveals-neolithic-farming-genetic-roots
#9
Alexey G Nikitin, Inna Potekhina, Nadin Rohland, Swapan Mallick, David Reich, Malcolm Lillie
The agricultural revolution in Eastern Europe began in the Eneolithic with the Cucuteni-Trypillia culture complex. In Ukraine, the Trypillian culture (TC) existed for over two millennia (ca. 5,400-2,700 BCE) and left a wealth of artifacts. Yet, their burial rituals remain a mystery and to date almost nothing is known about the genetic composition of the TC population. One of the very few TC sites where human remains can be found is a cave called Verteba in western Ukraine. This report presents four partial and four complete mitochondrial genomes from nine TC individuals uncovered in the cave...
2017: PloS One
https://www.readbyqxmd.com/read/28235006/genome-wide-effects-of-melk-inhibitor-in-triple-negative-breast-cancer-cells-indicate-context-dependent-response-with-p53-as-a-key-determinant
#10
Marisa Simon, Fahmi Mesmar, Luisa Helguero, Cecilia Williams
Triple-negative breast cancer (TNBC) is an aggressive, highly recurrent breast cancer subtype, affecting approximately one-fifth of all breast cancer patients. Subpopulations of treatment-resistant cancer stem cells within the tumors are considered to contribute to disease recurrence. A potential druggable target for such cells is the maternal embryonic leucine-zipper kinase (MELK). MELK expression is upregulated in mammary stem cells and in undifferentiated cancers, where it correlates with poor prognosis and potentially mediates treatment resistance...
2017: PloS One
https://www.readbyqxmd.com/read/28234991/severe-fever-with-thrombocytopenia-syndrome-virus-inhibits-exogenous-type-i-ifn-signaling-pathway-through-its-nss-invitro
#11
Xu Chen, Haiyan Ye, Shilin Li, Baihai Jiao, Jianqin Wu, Peibin Zeng, Limin Chen
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel bunyavirus (SFTS virus, SFTSV). At present there is still no specific antiviral treatment for SFTSV; To understand which cells support SFTSV life cycle and whether SFTSV infection activates host innate immunity, four different cell lines (Vero, Hela, Huh7.5.1, and Huh7.0) were infected with SFTSV. Intracellular/extracellular viral RNA and expression of IFNα, and IFNß were detected by real-time RT- PCR following infection...
2017: PloS One
https://www.readbyqxmd.com/read/28234983/comparison-of-the-hui3-and-the-eq-5d-3l-in-a-nursing-home-setting
#12
Tom Lung, Kirsten Howard, Christopher Etherton-Beer, Moira Sim, Gill Lewin, Glenn Arendts
BACKGROUND: Accurately assessing changes in the quality of life of older people living permanently in nursing homes is important. The multi-attribute utility instrument most commonly used and recommended to assess health-related quality of life in the nursing home population is the three-level EuroQol EQ-5D-3L. To date, there have been no studies using the Health Utilities Index Mark III (HUI3). The purpose of this study was to compare the level of agreement and sensitivity to change of the EQ-5D-3L and HUI3 in a nursing home population...
2017: PloS One
https://www.readbyqxmd.com/read/28234979/assessment-of-laboratory-and-daily-energy-expenditure-estimates-from-consumer-multi-sensor-physical-activity-monitors
#13
Enhad A Chowdhury, Max J Western, Thomas E Nightingale, Oliver J Peacock, Dylan Thompson
Wearable physical activity monitors are growing in popularity and provide the opportunity for large numbers of the public to self-monitor physical activity behaviours. The latest generation of these devices feature multiple sensors, ostensibly similar or even superior to advanced research instruments. However, little is known about the accuracy of their energy expenditure estimates. Here, we assessed their performance against criterion measurements in both controlled laboratory conditions (simulated activities of daily living and structured exercise) and over a 24 hour period in free-living conditions...
2017: PloS One
https://www.readbyqxmd.com/read/28234960/twenty-years-of-ecosystem-response-after-clearcutting-and-slashburning-in-conifer-forests-of-central-british-columbia-canada
#14
Julia R Chandler, Sybille Haeussler, Evelyn H Hamilton, Michael Feller, Gary Bradfield, Suzanne W Simard
Forests are being clearcut over extensive areas of western North America, but plant community response to harvesting and slashburning under varying climatic conditions in central British Columbia, Canada is still largely unknown. Evaluation of resilience is hampered by the short history of logging, lack of long-term experiments and methodological limitations. To test the effect of clearcut logging, prescribed burning and reforestation on forest resilience, we recorded vascular plant cover repeatedly after treatment between 1981 and 2008 in 16 permanent research installations in three biogeoclimatic zones: Engelmann Spruce-Subalpine Fir, Interior Cedar-Hemlock and Sub-Boreal Spruce...
2017: PloS One
https://www.readbyqxmd.com/read/28234951/association-of-maternal-age-with-child-health-a-japanese-longitudinal-study
#15
Tsuguhiko Kato, Takashi Yorifuji, Michiyo Yamakawa, Sachiko Inoue, Hiroyuki Doi, Akira Eboshida, Ichiro Kawachi
Average maternal age at birth has been rising steadily in Western and some Asian countries. Older maternal age has been associated with adverse pregnancy and birth outcomes; however, studies on the relationship between maternal age and young children's health remain scarce. Therefore, we sought to investigate the association of maternal age with child health outcomes in the Japanese population. We analyzed data from two birth cohorts of the nationwide Japanese Longitudinal Survey of Babies in 21st Century (n2001 = 47,715 and n2010 = 38,554)...
2017: PloS One
https://www.readbyqxmd.com/read/28234940/the-prevalence-of-insomnia-in-the-general-population-in-china-a-meta-analysis
#16
Xiao-Lan Cao, Shi-Bin Wang, Bao-Liang Zhong, Ling Zhang, Gabor S Ungvari, Chee H Ng, Lu Li, Helen F K Chiu, Grace K I Lok, Jian-Ping Lu, Fu-Jun Jia, Yu-Tao Xiang
: This is the first meta-analysis of the pooled prevalence of insomnia in the general population of China. A systematic literature search was conducted via the following databases: PubMed, PsycINFO, EMBASE and Chinese databases (China National Knowledge Interne (CNKI), WanFang Data and SinoMed). Statistical analyses were performed using the Comprehensive Meta-Analysis program. A total of 17 studies with 115,988 participants met the inclusion criteria for the analysis. The pooled prevalence of insomnia in China was 15...
2017: PloS One
https://www.readbyqxmd.com/read/28234910/hyperthermia-influences-fate-determination-of-neural-stem-cells-with-lncrnas-alterations-in-the-early-differentiation
#17
Lei Wang, Yujia Deng, Da Duan, Shuaiqi Sun, Lite Ge, Yi Zhuo, Ting Yuan, Pei Wu, Hao Wang, Ming Lu, Ying Xia
BACKGROUND: Temperature is an important parameter in the microenvironment of neural stem cells (NSCs); however, little is known about the precise effects of hyperthermia on fate determination in NSCs or the role of long non-coding (lnc)RNAs in this process. This was addressed in the present study using NSCs cultured at two different temperatures. METHODS: NSCs were divided into 37NSC and 40NSC groups that were cultured at 37°C or 40°C, respectively, for 72 h. Neuronal or glial cell differentiation was evaluated by flow cytometry and western blotting...
2017: PloS One
https://www.readbyqxmd.com/read/28234890/mir-200bc-429-inhibits-osteosarcoma-cell-proliferation-and-invasion-by-targeting-pmp22
#18
Xiaodong Li, Han Jiang, Lianping Xiao, Shusen Wang, Jinxin Zheng
BACKGROUND MicroRNAs (miRNAs) are small non-coding RNAs which play a crucial role in diverse biological processes and could contribute to cancer development and progression. MiR-200bc/429 have been found to be aberrantly expressed in osteosarcoma (OS). However, the features of miR-200bc/429 in the tumorigenesis and progress of OS remain poorly understood. MATERIAL AND METHODS The miR-200bc/429 expression was firstly identified in human OS clinical samples and cell lines by quantitative real-time PCR (qRT-PCR)...
February 24, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28234792/hydrogen-gas-protects-against-intestinal-injury-in-wild-type-but-not-nrf2-knockout-mice-with-severe-sepsis-by-regulating-ho-1-and-hmgb1-release
#19
Yang Yu, Yongyan Yang, Yingxue Bian, Yuan Li, Lingling Liu, Hongtao Zhang, Keliang Xie, Guolin Wang, Yonghao Yu
The intestine plays an important role in the pathogenesis of sepsis. Hydrogen gas (H2), which has anti-oxidative, anti-inflammatory, and anti-apoptotic effects, can be effectively used to treat septic mice. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a redox-sensitive master switch that regulates the expression of antioxidant and protective enzymes. This study investigated the effects of 2% H2 on intestinal injuries and the underlying mechanisms in a mouse model of severe sepsis. Male Nrf2-KO and wild-type (WT) mice were randomized into four groups: sham, sham+H2, cecal ligation and puncture (CLP), and CLP+H2...
February 23, 2017: Shock
https://www.readbyqxmd.com/read/28234688/placental-mitochondrial-toxicity-oxidative-stress-apoptosis-and-adverse-perinatal-outcomes-in-hiv-pregnancies-under-antiretroviral-treatment-containing-zidovudine
#20
Sandra Hernández, Marc Catalán-Garcia, Constanza Morén, Laura García-Otero, Marta López, Mariona Guitart-Mampel, Jose Milisenda, Oriol Coll, Francesc Cardellach, Eduard Gratacós, Òscar Miró, Gloria Garrabou
OBJECTIVE: To determine whether mitochondrial, oxidative and apoptotic abnormalities in placenta derived from Human Immunodeficiency Virus (HIV) and combined antiretroviral therapy (cART) containing zidovudine (AZT) could be associated with adverse perinatal outcome. DESIGN: Cross-sectional, controlled, observational study. METHODS: We studied obstetric results and mitochondrial, oxidative and apoptotic state in placenta of 24 treated HIV-infected and 32 uninfected pregnant women...
February 20, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
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