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https://www.readbyqxmd.com/read/28648041/-effects-of-hypoxia-on-the-phenotype-transformation-of-human-dermal-fibroblasts-to-myofibroblasts-and-the-mechanism
#1
B Zhao, F Han, W Zhang, X J Wang, J Zhang, F F Yang, J H Shi, L L Su, D H Hu
Objective: To investigate the effects of hypoxia on the phenotype transformation of human dermal fibroblasts to myofibroblasts and the mechanism. Methods: The third passage of healthy adult human dermal fibroblasts in logarithmic phase were cultured in DMEM medium containing 10% fetal bovine serum for the following five experiments. (1) In experiments 1, 2, and 3, cells were divided into normoxia group and hypoxia group according to the random number table, with 10 dishes in each group. Cells of normoxia group were cultured in incubator containing 21% oxygen, while those of hypoxia group with 1% oxygen...
June 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28648038/-effects-of-na-h-exchanger-1-inhibitor-on-intestinal-injury-of-rats-with-burn-sepsis-and-the-mechanism
#2
W P Li, G Y Zhao, X K Yang
Objective: To observe the effects of Na(+) /H(+) exchanger 1 (NHE1) inhibitor on intestinal injury of rats with burn sepsis, and to explore the possible mechanism preliminarily. Methods: Ninety SD rats were divided into control group, pure sepsis group, and NHE1 inhibitor group according to the random number table, with 30 rats in each group. Full-thickness scald (hereinafter referred to as burn) model with 20% total body surface area were reproduced on the back of rats in pure sepsis and NHE1 inhibitor groups, and then 50 μL liquid of Pseudomonas aeruginosa ATCC 27853 (2×10(5) colony forming unit/mL) were injected into the center of wounds on the back...
June 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28648037/-effects-of-activating-silent-information-regulator-1-on-early-kidney-damage-in-rats-with-severe-burn
#3
X Z Bai, T He, Y Liu, W Zhang, F Han, C Yang, W X Cai, Y H Jia, J H Shi, J T Han, L L Su, D H Hu
Objective: To investigate the effects of activating silent information regulator 1 (SIRT1) on the early kidney damage in rats with severe burn. Methods: Thirty healthy male SD rats were divided into sham injury group (SI), pure burn group (PB), and SIRT1 activator group (SA) according to the random number table, with 10 rats in each group. Rats in groups PB and SA were inflicted with 30% total body surface area full-thickness scald (hereinafter referred to as burn) on the back. Immediately after injury, rats in group PB were intraperitoneally injected with normal saline in the dosage of 50 mL/kg, and those in group SA with 1 mg/mL (final mass concentration) resveratrol in the dosage of 50 mL/kg...
June 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28648030/-effect-and-mechanism-of-intermittent-alkaline-stimulation-on-high-phosphorus-induced-calcification-in-vascular-smooth-muscle-cells-of-rats
#4
Y L Bai, J S Xu, T Tian, J X Zhang, L W Cui, H R Zhang, S L Zhang
Objective: To explore the effect and possible mechanisms of intermittent alkaline on rat vascular smooth muscle cells (VSMCs) calcification induced by high phosphorus. Methods: VSMCs were isolated from rat thoracic aorta and cultured in vitro. The fourth generation VSMCs were randomly divided into control group, high phosphorus+ pH7.4, high phosphorus+ pH7.5, high phosphorus+ pH7.6 and high phosphorus+ pH7.7 group with random number table. The control group was cultured in DMEM with 10% fetal bovine serum. Other groups were cultured in DMEM with 10 mmol/L β-glycerophosphate and alkalized by 7...
June 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28648028/-expression-changes-of-notch-and-nuclear-factor-%C3%AE%C2%BAb-signaling-pathways-in-the-rat-heart-with-myocardial-infarction
#5
J L Jin, Z T Deng, R G Lyu, X H Liu, J R Wei
Objective: To observe the expression changes of Notch and nuclear factor-κB (NF-κB) signaling pathways in rat myocardium post myocardial infarction. Methods: Myocardial infarction was established by ligation of the left anterior descending coronary artery(MI group), sham rats (similar surgical procedure without coronary artery ligation) served as control, the rats were sacrificed at first week, 4th and 8th week after operation, the non-infarct myocardial tissue in both groups was obtained to detect the mRNA expression of Notch1, Dll4 and Hes1 by RT-PCR, the protein expression of NICD1 was detected by Western blot, the nuclear protein p65 content was detected to reflect the activation degree of NF-κB signaling in the cardiomyocytes...
June 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28648027/-sirt1-signaling-pathway-mediated-the-protective-effects-on-myocardium-of-rats-after-endurance-training-and-acute-exhaustive-exercise
#6
X Y Li, X Han, H M Zhang, H Tan, S F Han
Objective: To detect the expression of SIRT1 and Ac-FOXO1 in rats after endurance training and acute exhaustive exercise, and explicit the myocardial protective effect of SIRT1. Methods: Rats were randomly divided into four groups: control group(n=20), exhaustive exercise group (E group, n=20), exhaustive exercise group + endurance training (TE group, n=18), exhaustive exercise group + endurance training + selective SIRT1 inhibitor (TSE group, n=17). The Control and E groups were fed routinely for 5 weeks. The TE and TSE groups were subjected to swimming exercise for 5 weeks for endurance exercising...
June 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28648016/-mechanisms-of-cytoskeleton-and-pi3k%C3%AE-rhoa-in-fine-particulate-matter-deteriorating-phagocytosis-defect-of-alveolar-macrophage-in-mice-with-chronic-obstructive-pulmonary-disease
#7
Q Xia, S T Hu, X L Zeng, H R Bao, X J Liu
Objective: To explore the mechanism of cytoskeleton and PI3Kδ-RhoA in fine particulate matter deteriorating phagocytosis defect of alveolar macrophage (AM) in chronic obstructive pulmonary disease (COPD) mice. Methods: Forty mice were randomly divided into four groups: health control group, COPD group, health PM2.5 group, COPD PM2.5 group and with ten in each group. A mouse model of COPD was established by cigarette smoke exposure, and health PM2.5 group and COPD PM2.5 group mice were given PM2.5 (588 μg/m(3)) aerosol inhalation for 90 days...
June 27, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28648006/-0-5-gy-x-ray-radiation-promotes-osteoblast-differentiation-by-wnt-%C3%AE-catenin-signaling
#8
M Chen, Q R Dong, Q Huang, C She, W Xu
Objective: To investigate the important roles of Wnt signaling in the processes of 0.5Gy X-ray promoting osteoblast differentiation, and make clear the molecular mechanisms involved. Methods: Flow cytometry was employed to detect the apoptosis after osteoblast exposure to 0.5 Gy X-ray radiation.The protein level of osteoblast differentiation markers, such as collagen Iα (Col1α), alkaline phosphatase (ALP), osteocalcin (OCN), were detected by Western-blot and ALP activity staining was performed. Real-time PCR and Western-blot were utilized to evaluate the variations of key factors in Wnt signaling pathways, while specific inhibitor of Wnt/β-Catenin, XAV939 was used to block the Wnt signaling...
June 20, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28647962/-effect-of-endoplasmic-reticulum-stress-in-trophocytes-on-the-pathogenesis-of-intrahepatic-cholestasis-of-pregnancy
#9
Y Yu, C L Zhou, T T Yu, X J Han, H Y Shi, H Z Wang, J J Shen, J He
Objective: To evaluate the effect of endoplasmic reticulum stress in trophocytes, in patients with intrahepatic cholestasis of pregnancy (ICP). Methods: Sixty-one pregnant women who were hospitalized in Women's Hospital, School of Medicine, Zhejiang University from January to December 2015 were recruited. Thirty-one women who were diagnosed as ICP were defined as the ICP group and 30 healthy pregnant women were defined as the control group. The localization and expression intensity of glucose regulated protein 78 (GRP-78) in placental tissues were detected by immunohistochemistry technique...
June 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28647911/religiosity-and-healthy-lifestyle-behaviours-in-malaysian-muslims-the-mediating-role-of-subjective-well-being-and-self-regulation
#10
Swan Ee Tey, Miriam Sang-Ah Park, Karen Jennifer Golden
Past research on healthy lifestyle behaviours has been primarily conducted within Western or Judeo-Christian contexts, while non-Western or Muslim contexts remain under-represented. This study examined predictors of healthy lifestyle behaviours (religiosity, goal-setting, impulse control, and subjective well-being) in Malaysian Muslims and explored the mechanisms underlying the relationship between religiosity and healthy lifestyle behaviours. Self-report survey responses from 183 healthy adults (M age = 28...
June 24, 2017: Journal of Religion and Health
https://www.readbyqxmd.com/read/28647906/exogenous-gdf11-induces-cardiac-and-skeletal-muscle-dysfunction-and-wasting
#11
Teresa A Zimmers, Yanling Jiang, Meijing Wang, Tiffany W Liang, Joseph E Rupert, Ernie D Au, Francesco E Marino, Marion E Couch, Leonidas G Koniaris
Growth differentiation factor 11 (GDF11), a TGF-beta superfamily member, is highly homologous to myostatin and essential for embryonic patterning and organogenesis. Reports of GDF11 effects on adult tissues are conflicting, with some describing anti-aging and pro-regenerative activities on the heart and skeletal muscle while others opposite or no effects. Herein, we sought to determine the in vivo cardiac and skeletal muscle effects of excess GDF11. Mice were injected with GDF11 secreting cells, an identical model to that used to initially identify the in vivo effects of myostatin...
July 2017: Basic Research in Cardiology
https://www.readbyqxmd.com/read/28647842/excellent-healing-rates-and-patient-satisfaction-after-arthroscopic-repair-of-medium-to-large-rotator-cuff-tears-with-a-single-row-technique-augmented-with-bone-marrow-vents
#12
Brian D Dierckman, Jake J Ni, Ronald P Karzel, Mark H Getelman
PURPOSE: This study evaluated the repair integrity and patient clinical outcomes following arthroscopic rotator cuff repair of medium to large rotator cuff tears using a single-row technique consisting of medially based, triple-loaded anchors augmented with bone marrow vents in the rotator cuff footprint lateral to the repair. METHODS: This is a retrospective study of 52 patients (53 shoulders) comprising 36 males and 16 females with a median age of 62 (range 44-82) with more than 24-month follow-up, tears between 2 and 4 cm in the anterior-posterior dimension and utilizing triple-loaded anchors...
June 24, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28647835/resveratrol-alleviates-inflammatory-hyperalgesia-by-modulation-of-reactive-oxygen-species-ros-antioxidant-enzymes-and-erk-activation
#13
Ajeet Kumar Singh, Manjula Vinayak
OBJECTIVES: Impact of ROS in development of hyperalgesia has recently motivated scientists to focus on ROS as novel target of anti-hyperalgesic interventions. However, role of ROS in molecular signaling of hyperalgesia is still poorly understood. The present study is aimed to analyze the effect of dietary antioxidant resveratrol on antioxidant defense system, ROS level and TNFR1-ERK signaling pathway during early and late phase of inflammatory hyperalgesia. METHODS AND MATERIALS: Hyperalgesia was assessed by paw withdrawal latency test in complete Freund's adjuvant-induced hyperalgesic rats...
June 24, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28647755/namib-desert-soil-microbial-community-diversity-assembly-and-function-along-a-natural-xeric-gradient
#14
Vincent Scola, Jean-Baptiste Ramond, Aline Frossard, Olivier Zablocki, Evelien M Adriaenssens, Riegardt M Johnson, Mary Seely, Don A Cowan
The hyperarid Namib desert is a coastal desert in southwestern Africa and one of the oldest and driest deserts on the planet. It is characterized by a west/east increasing precipitation gradient and by regular coastal fog events (extending up to 75 km inland) that can also provide soil moisture. In this study, we evaluated the role of this natural aridity and xeric gradient on edaphic microbial community structure and function in the Namib desert. A total of 80 individual soil samples were collected at 10-km intervals along a 190-km transect from the fog-dominated western coastal region to the eastern desert boundary...
June 24, 2017: Microbial Ecology
https://www.readbyqxmd.com/read/28647749/expression-of-high-mobility-group-box-1-protein-hmgb1-and-toll-like-receptor-9-tlr9-in-retinas-of-diabetic-rats
#15
Shuang Jiang, Xiaolong Chen
BACKGROUND Diabetic retinopathy (DR) and diabetic optic neuropathy are important complications of diabetes mellitus (DM) which can lead to blindness in diabetic patients. Recent studies showed that chronic low-grade inflammation is thought to be one of the important pathophysiological mechanisms in the occurrence and development of DR and diabetes optic neuropathy. This study explored the expressions of inflammatory factors HMGB-1 and TLR9. MATERIAL AND METHODS SD rats were randomly divided into a diabetic mellitus group and a control group...
June 25, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28647730/qiliqiangxin-attenuates-adverse-cardiac-remodeling-after-myocardial-infarction-in-ovariectomized-mice-via-activation-of-ppar%C3%AE
#16
Shutong Shen, Huimin Jiang, Yihua Bei, Jialiang Zhang, Haifeng Zhang, Hongsheng Zhu, Chenlin Zhang, Wenming Yao, Cong Wei, Hongcai Shang, Xinli Li
BACKGROUND/AIMS: This study was designed to investigate the therapeutic effect of traditional Chinese medication Qiliqiangxin (QLQX) on adverse cardiac remodeling after myocardial infarction (MI) in bilateral ovariectomized (OVX) female mice. METHODS: Eight-week old female C57BL/6 mice were operated to ligate the left anterior descending coronary artery seven days after bilateral ovariectomy and were orally administered either QLQX or vehicle. 21 days after ligation, echocardiography was performed to evaluate the heart function of all mice...
June 23, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28647699/proteomic-analysis-of-normal-and-cancer-cervical-cell-lines-reveals-deregulation-of-cytoskeleton-associated-proteins
#17
Kalliopi I Pappa, Vasiliki Lygirou, Georgia Kontostathi, Jerome Zoidakis, Manousos Makridakis, Konstantinos Vougas, George Daskalakis, Alexander Polyzos, Nicholas P Anagnou
BACKGROUND: Both HPV-positive and -negative cervical cancers are primarily associated with features of cell cycle and cytoskeletal disruption; however, the actual biological processes affected remain elusive. To this end, we systematically characterized the intracellular proteomic profiles of four distinct and informative cervical cell lines. MATERIALS AND METHODS: Cell extracts from a normal cervical (HCK1T) and three cervical cancer cell lines, one HPV-negative (C33A), and two HPV-positive, SiHa (HPV16+) and HeLa (HPV18+), were analyzed by 2-dimensional electrophoresis and differentially expressed proteins were identified by MALDI-TOF mass spectrometry, while differential expression was confirmed by western blot analysis...
July 2017: Cancer Genomics & Proteomics
https://www.readbyqxmd.com/read/28647679/factors-impacting-on-psychological-wellbeing-of-international-students-in-the-health-professions-a-scoping-review
#18
REVIEW
Lisa McKenna, Eddie Robinson, Joy Penman, Danny Hills
BACKGROUND: There are increasing numbers of international students undertaking health professional courses, particularly in Western countries. These courses not only expose students to the usual stresses and strains of academic learning, but also require students to undertake clinical placements and practice-based learning. While much is known about general issues facing international students, less is known about factors that impact on those studying in the health professions. OBJECTIVES: To explore what is known about factors that influence the psychological wellbeing of international students in the health professions...
June 17, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28647647/itraq-based-quantitative-analysis-of-alveolar-bone-resorption-in-rats-with-experimental-periodontitis
#19
Weidong Yang, Yafan Gao, Yajie Qian, Jingjing Li, Qingang Hu
OBJECTIVE: Periapical periodontitis results in alveolar bone resorption around the root apex. During the progression of inflammation, host cells release various inflammatory mediators and pro-inflammatory cytokines through immune responses. However, the pathological mechanisms associated with periapical bone destruction remain unclear. This study was objected to identify differentially regulated proteins in periapical periodontitis via a quantitative proteomics approach using isobaric tags for relative and absolute quantification (iTRAQ) labelling of peptides...
June 13, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28647618/genetic-and-ecological-processes-promoting-early-diversification-in-the-lowland-mesoamerican-bat-sturnira-parvidens-chiroptera-phyllostomidae
#20
Giovani Hernández-Canchola, Livia León-Paniagua
With 22 species, Sturnira is the most speciose genus of frugivorous Neotropical bats. Sturnira parvidens inhabits lowland tropical areas from Mexico to Central America. The elevation of this taxon to species level was recent, and discrepancies with respect to its geographic limits and phylogenetic position continue to exist. In order to identify genetic and ecological processes likely involved in the diversification and current distribution of S. parvidens, we evaluated relationships, researched phylogeographic and demographic history, and tested the divergence/conservatism of the climatic niche of this bat...
June 21, 2017: Molecular Phylogenetics and Evolution
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