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https://www.readbyqxmd.com/read/28821002/modeling-the-fate-and-transport-of-17%C3%AE-estradiol-in-the-south-river-watershed-in-virginia
#1
Xiaomin Zhao, Wu-Seng Lung
Hormones excreted by livestock metabolisms often enter surface water through feces and urine and can potentially cause adverse impacts to aquatic biota. This study involved a modeling analysis of 17β-estradiol (E2), a prevalent estrogen, in the South River watershed located in Augusta County, Virginia from 2013 to 2015. Cattle manure, poultry litter, biosolids, septic systems, and wastewater treatment plants (WWTPs) were considered as sources of E2 in this study. The EPA's BASINS modeling framework was configured to track the fate and transport of E2...
August 13, 2017: Chemosphere
https://www.readbyqxmd.com/read/28818330/manufacturing-in-the-eye-of-the-storm-shen-hong-and-the-nine-great-installations-project-during-china-s-cultural-revolution
#2
Lie Sun, Danian Hu
The construction of nine high-end technical installations (hereafter Project NGI, for Nine Great Installations or ) in the 1960s and 1970s was an indispensable part of the development of China's defense and heavy industries. The project put more than 1400 machines into operation or trial operation during the Culture Revolution (1966-1976), and they served essential technical functions in sectors such as aviation, aerospace, machinery, metallurgy, and electronics, and directly advancing the development of these fields...
August 14, 2017: Endeavour
https://www.readbyqxmd.com/read/28817343/suppression-of-choroidal-neovascularization-in-mice-by-subretinal-delivery-of-multigenic-lentiviral-vectors-encoding-anti-angiogenic-micrornas
#3
Anne Louise Askou, Josephine Natalia Esther Benckendorff, Andreas Holmgaard, Tina Storm, Lars Aagaard, Toke Bek, Jacob Giehm Mikkelsen, Thomas Juhl Corydon
Lentivirus-based vectors have been used for the development of potent gene therapies. Here, application of a multigenic lentiviral vector (LV) producing multiple anti-angiogenic microRNAs following subretinal delivery in a laser-induced choroidal neovascularization (CNV) mouse model is presented. This versatile LV, carrying back-to-back RNApolII-driven expression cassettes, enables combined expression of microRNAs targeting vascular endothelial growth factor A (Vegfa) mRNA and fluorescent reporters. In addition, by including a vitelliform macular dystrophy 2 (VMD2) promoter, expression of microRNAs is restricted to the retinal pigment epithelial (RPE) cells...
August 2017: Human Gene Therapy Methods
https://www.readbyqxmd.com/read/28817194/prediction-and-prognosis-of-ventricular-tachycardia-recurrence-after-catheter-ablation-with-remote-magnetic-navigation-for-electrical-storm-in-patients-with-ischemic-cardiomyopathy
#4
Qi Jin, Peter Karl Jacobsen, Steen Pehrson, Xu Chen
BACKGROUND: Ventricular tachycardia (VT) recurrence after catheter ablation for electrical storm is commonly seen in patients with ischemic cardiomyopathy (ICM). HYPOTHESIS: We hypothesized that VT recurrence can be predicted and be related to the all-cause death after VT storm ablation guided by remote magnetic navigation (RMN) in patients with ICM. METHODS: A total of 54 ICM patients (87% male; mean age, 65 ± 7.1 years) presenting with VT storm undergoing acute ablation using RMN were enrolled...
August 17, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28816118/paroxysmal-sympathetic-hyperactivity-the-storm-after-acute-brain-injury
#5
REVIEW
Geert Meyfroidt, Ian J Baguley, David K Menon
A substantial minority of patients who survive an acquired brain injury develop a state of sympathetic hyperactivity that can persist for weeks or months, consisting of periodic episodes of increased heart rate and blood pressure, sweating, hyperthermia, and motor posturing, often in response to external stimuli. The unifying term for the syndrome-paroxysmal sympathetic hyperactivity (PSH)-and clear diagnostic criteria defined by expert consensus were only recently established. PSH has predominantly been described after traumatic brain injury (TBI), in which it is associated with worse outcomes...
September 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28814971/quality-of-life-in-anxious-adolescents
#6
Solfrid Raknes, Ståle Pallesen, Joseph A Himle, Jon Fauskanger Bjaastad, Gro Janne Wergeland, Asle Hoffart, Kari Dyregrov, Åshild Tellefsen Håland, Bente Storm Mowatt Haugland
PURPOSE: To examine associations between health-related quality of life (HRQoL) and anxiety symptoms across anxiety domains (obsessions/compulsions, social anxiety, panic disorder, agoraphobia, separation anxiety, physical injury fears, generalised anxiety, and posttraumatic stress) in a general adolescent population. Expanded knowledge about these associations can provide valuable information for improving interventions and prevention strategies for adolescent anxiety. METHODS: Cross-sectional data about anxiety were collected via a school survey from a community sample of Norwegian adolescents aged 12-17 (N = 1719)...
2017: Child and Adolescent Psychiatry and Mental Health
https://www.readbyqxmd.com/read/28813294/weathering-the-storm-the-impact-of-trauma-on-romantic-relationships
#7
REVIEW
Emma M Marshall, Roeline G Kuijer
The current paper reviews the recent literature examining the impact of trauma on romantic relationships. We introduce the Dyadic Responses to Trauma (DRT) Model as a framework for organizing existing research and guiding future research. A traumatic event affects romantic relationships for the better or for the worse depending on the diverse trauma-related experiences people can have, influencing the way partners interact with each other and ultimately the quality of the relationship. In addition, recent research demonstrates how romantic partners can demonstrate resiliency in spite of a negative trauma experience depending on how they interpret and cope with the experience individually and as a couple...
February 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/28811887/lessons-from-the-t%C3%A5-hoku-tsunami-a-model-for-island-avifauna-conservation-prioritization
#8
Michelle H Reynolds, Paul Berkowitz, John L Klavitter, Karen N Courtot
Earthquake-generated tsunamis threaten coastal areas and low-lying islands with sudden flooding. Although human hazards and infrastructure damage have been well documented for tsunamis in recent decades, the effects on wildlife communities rarely have been quantified. We describe a tsunami that hit the world's largest remaining tropical seabird rookery and estimate the effects of sudden flooding on 23 bird species nesting on Pacific islands more than 3,800 km from the epicenter. We used global positioning systems, tide gauge data, and satellite imagery to quantify characteristics of the Tōhoku earthquake-generated tsunami (11 March 2011) and its inundation extent across four Hawaiian Islands...
August 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28811662/fractal-properties-of-shoreline-changes-on-a-storm-exposed-island
#9
Xiaojing Zhong, Peng Yu, Shenliang Chen
Extreme storm events and their consequent shoreline changes are of great importance for understanding coastal evolution and assessing storm hazards. This work investigates the fractal properties of the spatial distributions of shoreline changes caused by storms. Wavelet analysis and upper-truncated power law (UTPL) fitting are used to study the power spectra of shoreline changes and to evaluate the upper limits of the cross-shore erosion and accretion. During a period affected by storms, the alongshore shoreline change patterns are strong on the 15 km scale but are weak with lower spectral power on the 20 km scale...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811494/on-the-shape-and-likelihood-of-oceanic-rogue-waves
#10
Alvise Benetazzo, Fabrice Ardhuin, Filippo Bergamasco, Luigi Cavaleri, Pedro Veras Guimarães, Michael Schwendeman, Mauro Sclavo, Jim Thomson, Andrea Torsello
We consider the observation and analysis of oceanic rogue waves collected within spatio-temporal (ST) records of 3D wave fields. This class of records, allowing a sea surface region to be retrieved, is appropriate for the observation of rogue waves, which come up as a random phenomenon that can occur at any time and location of the sea surface. To verify this aspect, we used three stereo wave imaging systems to gather ST records of the sea surface elevation, which were collected in different sea conditions...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28808944/effect-of-ha330-resin-directed-hemoadsorption-on-a-porcine-acute-respiratory-distress-syndrome-model
#11
Xuefeng Xu, Chune Jia, Sa Luo, Yanming Li, Fei Xiao, Huaping Dai, Chen Wang
BACKGROUND: Blood purification is an emerging approach to dampening the cytokine storm. This study aims to assess the efficacy of HA330 resin-directed hemoadsorption (HA) on endotoxin-induced porcine acute respiratory distress syndrome (ARDS) model. METHODS: Twenty-four Chinese domestic pigs were allocated into saline group receiving intravenous infusion of saline (N = 6) and endotoxin group receiving intravenous infusion of LPS (N = 18). When ALI model was initially diagnosed, six pigs in the LPS and saline group were killed for BALF and histopathological analysis...
August 14, 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28806490/challenges-and-resources-for-nurses-participating-in-a-hurricane-sandy-hospital-evacuation
#12
Nancy VanDevanter, Victoria H Raveis, Christine T Kovner, Meriel McCollum, Ronald Keller
PURPOSE: Weather-related disasters have increased dramatically in recent years. In 2012, severe flooding as a result of Hurricane Sandy necessitated the mid-storm patient evacuation of New York University Langone Medical Center. The purpose of this study was to explore, from the nurses' perspective, what the challenges and resources were to carrying out their responsibilities, and what the implications are for nursing education and preparation for disaster. DESIGN: This mixed-methods study included qualitative interviews with a purposive sample of nurses and an online survey of nurses who participated in the evacuation...
August 14, 2017: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/28806393/craf-gene-fusions-in-pediatric-low-grade-gliomas-define-a-distinct-drug-response-based-on-dimerization-profiles
#13
P Jain, T M Fierst, H J Han, T E Smith, A Vakil, P J Storm, A C Resnick, A J Waanders
Pediatric low-grade gliomas (PLGGs) are commonly associated with BRAF gene fusions that aberrantly activate the mitogen-activated protein kinase (MAPK) signaling pathway. This has led to PLGG clinical trials utilizing RAF- and MAPK pathway-targeted therapeutics. Whole-genome profiling of PLGGs has also identified rare gene fusions involving another RAF isoform, CRAF/RAF1, in PLGGs and cancers occuring in adults. Whereas BRAF fusions primarily dysregulate MAPK signaling, the CRAF fusions QKI-RAF1 and SRGAP3-RAF1 aberrantly activate both the MAPK and phosphoinositide-3 kinase/mammalian target of rapamycin (PI3K/mTOR) signaling pathways...
August 14, 2017: Oncogene
https://www.readbyqxmd.com/read/28805591/acute-presentation-of-nonmotor-symptoms-in-parkinson-s-disease
#14
Kimberly Kwei, Steven Frucht
There are a few syndromes involving the nonmotor symptoms of Parkinson's disease and other movement disorders that can quickly lead to severe morbidity and mortality, and, as such, need rapid identification and management. Among these are neuroleptic malignant syndrome, serotonin syndrome, dopamine agonist withdrawal syndrome, and dystonic storm. It is important to maintain a high index of suspicion for these disorders as lack of identification can lead to death. Many of these acutely occurring nonmotor syndromes are primarily the result of imbalances in dopaminergic and serotonergic systems due to changes in pharmacologic management of psychiatric disorders or Parkinson's disease...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28803583/cross-sectional-survey-of-long-term-care-facilities-in-the-rockaway-peninsula-preparedness-and-response-during-hurricane-sandy
#15
Lynn Jiang, Christopher Tedeschi, Saleena Subaiya
BACKGROUND: Few studies have described the challenges experienced by long-term care facilities (LTCFs) following Hurricane Sandy. This study examined LTCF preparedness and experiences during and after the storm. METHODS: A cross-sectional survey was conducted 2 years after Hurricane Sandy to assess LTCF demographics, preparation, and post-storm resources. Surveys were conducted at LTCFs located on the Rockaway Peninsula of New York City. All LTCFs located in a heavily affected area were approached...
August 14, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28803515/protocol-driven-remote-monitoring-of-cardiac-resynchronization-therapy-as-part-of-a-heart-failure-disease-management-strategy
#16
Christophe J P Smeets, Frederik H Verbrugge, Julie Vranken, Jo Van der Auwera, Wilfried Mullens, Matthias Dupont, Lars Grieten, Hélène De Cannière, Dorien Lanssens, Thijs Vandenberk, Valerie Storms, Inge M Thijs, Pieter Vandervoort
BACKGROUND: Cardiac resynchronisation therapy (CRT) is an established treatment for heart failure (HF) with reduced ejection fraction. CRT devices are equipped with remote monitoring functions, which are pivotal in the detection of device problems, but may also facilitate disease management. The aim of this study was to provide a comprehensive overview of the clinical interventions taken based on remote monitoring. METHODS: This is a single centre observational study of consecutive CRT patients (n = 192) participating in protocol-driven remote follow-up...
August 14, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28803153/comparison-of-sediment-and-nutrient-export-and-runoff-characteristics-from-watersheds-with-centralized-versus-distributed-stormwater-management
#17
Kristina G Hopkins, J V Loperfido, Laura S Craig, Gregory B Noe, Dianna M Hogan
Stormwater control measures (SCMs) are used to retain stormwater and pollutants. SCMs have traditionally been installed in a centralized manner using detention to mitigate peak flows. Recently, distributed SCM networks that treat runoff near the source have been increasingly utilized. The aim of this study was to evaluate differences among watersheds that vary in SCM arrangement by assessing differences in baseflow nutrient (NOx-N and PO4(-)) concentrations and fluxes, stormflow export of suspended sediments and particulate phosphorus (PP), and runoff characteristics...
August 9, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28802656/rethinking-papillary-muscle-resection-for-refractory-ventricular-tachycardia-in-the-lvad-era-a-case-report
#18
Zachary J Il'Giovine, Adam D DeVore, Chetan B Patel, Jason Koontz, Jacob Schroder
We report the case of a 57-year-old man with a history of ischemic cardiomyopathy who presented to the hospital with recurrent episodes of ventricular tachycardia refractory to antiarrhythmic medications. Mapping identified a deep premature ventricular contraction focus in the anterolateral papillary muscle, an area that has been previously identified as difficult to treat with radiofrequency catheter ablation. The hospital course was complicated by cardiogenic shock and VT-storm, and the patient ultimately underwent surgical resection of the anterolateral papillary muscle with left ventricular assist device placement as a successful bridge to cardiac transplantation...
July 12, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28802448/user-perception-and-interpretation-of-tornado-probabilistic-hazard-information-comparison-of-four-graphical-designs
#19
Seyed M Miran, Chen Ling, Joseph J James, Alan Gerard, Lans Rothfusz
Effective design for presenting severe weather information is important to reduce devastating consequences of severe weather. The Probabilistic Hazard Information (PHI) system for severe weather is being developed by NOAA National Severe Storms Laboratory (NSSL) to communicate probabilistic hazardous weather information. This study investigates the effects of four PHI graphical designs for tornado threat, namely, "four-color"," red-scale", "grayscale" and "contour", on users' perception, interpretation, and reaction to threat information...
November 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28801569/global-assessment-of-flood-and-storm-extremes-with-increased-temperatures
#20
Conrad Wasko, Ashish Sharma
There is overwhelming consensus that the intensity of heavy precipitation events is increasing in a warming world. It is generally expected such increases will translate to a corresponding increase in flooding. Here, using global data sets for non-urban catchments, we investigate the sensitivity of extreme daily precipitation and streamflow to changes in daily temperature. We find little evidence to suggest that increases in heavy rainfall events at higher temperatures result in similar increases in streamflow, with most regions throughout the world showing decreased streamflow with higher temperatures...
August 11, 2017: Scientific Reports
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