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Iron and blood sugar

Fuyuko Sasaki, Sumihiro Kawajiri, Sho Nakajima, Ai Yamaguchi, Yuji Tomizawa, Kazuyuki Noda, Nobutaka Hattori, Yasuyuki Okuma
BACKGROUND: Nonketotic hyperglycemia often causes seizures. Recently, seizures associated with nonketotic hyperglycemia have been found to be associated with subcortical T2 hypointensity on magnetic resonance imaging, especially in the occipital lobes. However, the mechanism remains unclear, although iron accumulation is suggested. We present a case of occipital lobe seizures associated with nonketotic hyperglycemia supporting the hypothesis that the mechanism of subcortical T2 hypointensity is iron accumulation using gradient-echo T2*-weighted magnetic resonance imaging...
2016: Journal of Medical Case Reports
Adel Eftekhari, Khadijeh Nasiriani, Samaneh Mirzaei, Somayeh Azimpour Ardakani
INTRODUCTION: The restless leg syndrome (RLS) is a neurologic disorder suffering the hemodialysis patients. Although the pathophysiology of this syndrome remains unknown yet, an investigation of the parameters pertinent to it may help to develop the related medical knowledge and to improve the therapeutic-care interventions in this regard. OBJECTIVES: The correlation between the RLSs on individual, clinical, and laboratory indices in patients undergoing hemodialysis...
2016: Journal of Renal Injury Prevention
Richard I Lowensohn, Diane D Stadler, Christie Naze
BACKGROUND: A nutrient-rich maternal diet before and during pregnancy is associated with improved fetal health, more appropriate birth weight, and increased rates of maternal and infant survival. Physicians need a better understanding of the role of diet in shaping fetal outcomes. Given this background, we reviewed and summarized articles on maternal nutrition found in MEDLINE since 1981, written in English, and limited to human subjects. FOR THE OFFSPRING: Maternal diets high in sugar and fat lead to an increased incidence of metabolic syndrome, diabetes, and cardiovascular disease later in life...
August 2016: Obstetrical & Gynecological Survey
Nicole K Bart, M Kate Curtis, Hung-Yuan Cheng, Sara L Hungerford, Ross McLaren, Nayia Petousi, Keith L Dorrington, Peter A Robbins
Sustained hypoxia over several hours induces a progressive rise in pulmonary artery systolic pressure (PASP). Administration of intravenous iron immediately prior to the hypoxia exposure abrogates this effect, suggesting that manipulation of iron stores may modify hypoxia-induced pulmonary hypertension. Iron (ferric carboxymaltose) administered intravenously has a plasma half-life of 7-12 h. Thus any therapeutic use of intravenous iron would require its effect on PASP to persist long after the iron-sugar complex has been cleared from the blood...
August 1, 2016: Journal of Applied Physiology
Nicholas P Vitko, Melinda R Grosser, Dal Khatri, Thurlow R Lance, Anthony R Richardson
UNLABELLED: Acquisition of numerous virulence determinants affords Staphylococcus aureus greater pathogenicity than other skin-colonizing staphylococci in humans. Additionally, the metabolic adaptation of S. aureus to nonrespiratory conditions encountered during infection (e.g., hypoxia, nitric oxide, iron chelation) has been implicated as contributing to S. aureus virulence. Specifically, S. aureus has been shown to ferment glycolytic substrates in nonrespiratory environments encountered within the host...
2016: MBio
T A Sultana, Z A Sheme, G S Sultana, B Sultana, F A Mishu, N Z Khan, B C Sarkar, M A Muttalib, S A Khan, S Choudhury, H Mahtab
Hemoglobin A1c (HbA(1)c) is a well-established indicator of mean glycemia. The presence of genetic variants of hemoglobin can profoundly affect the accuracy of HbA(1)c measurements. Variants of hemoglobin especially Hemoglobin E (HbE) is prevalent in South East Asia including Bangladesh. The objective of our study is to compare the HbA(1)c values measured on high performance liquid chromatography (HPLC) and Turbidimetric Inhibition Immunoassay (TINIA) in diabetic patients with variant hemoglobins including HbE...
April 2016: Mymensingh Medical Journal: MMJ
Queenie Chan, Jeremiah Stamler, Linda M Oude Griep, Martha L Daviglus, Linda Van Horn, Paul Elliott
Adverse blood pressure (BP) is a major independent risk factor for epidemic cardiovascular diseases affecting almost one-quarter of the adult population worldwide. Dietary intake is a major determinant in the development and progression of high BP. Lifestyle modifications, including recommended dietary guidelines, are advocated by the American Society of Hypertension, the International Society of Hypertension, the Japanese Society of Hypertension, and many other organisations for treating all hypertensive people, prior to initiating drug therapy and as an adjunct to medication in persons already on drug therapy...
2016: Journal of Atherosclerosis and Thrombosis
Mariko Nishikitani, Yasunobu Nohara, Partha Ghosh, Rafiqul Islam Maruf, Ashir Ahmed, Naoki Nakashima
The residents of several cities and villages in Bangladesh underwent e-health checkups. The distribution of Hb increased from the first hemoglobin (Hb) measurement to the second, and some women recovered from severe anemia. A strong effect was observed in subjects who were prescribed iron supplements. The mean blood pressure improved after the first health examination, and the blood sugar level increased. In countries with shortages of health practitioners and health care providers, e-health examinations and instructions may be useful interventions because they make people health conscious and improve their health status...
2015: Studies in Health Technology and Informatics
Filiz Eren, Nursel Türkmen Inanir, Recep Fedakar, Bülent Eren, Murat Serdar Gürses
Magnesite (MgCO3) is a mineral which is theoretically composed of 52.2% CO2, 47.8% MgO, and very scarce amounts of Fe2O3 with a degree of hardness varying between 3.4-4.5 kgf, and specific gravity of 2.9-3.1 g/cm(3). Its color varies between white, yellow or gray, and brown. Magnesite is used in agriculture, and drug industry, brick, iron-steel, paper, and sugar industries. Our case was a 30-year-old male whose dead was reportedly associated with exposure to 2700°C molten magnesite in the melting potansiyel of the plant where he was working as a metal worker...
March 2015: Mædica
Faiza Alam, Fasiha Fatima, Shehryar Orakzai, NajeehaTalat Iqbal, Syeda Sadia Fatima
OBJECTIVES: To measure the levels of high-sensitivity C-reactive protein and ferritin in blood and to assess their association with inflammation in people with Type 2 diabetes. METHOD: The case-control study was conducted between November 2012 to November 2013 at the Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre, Karachi, and comprised randomly selected patients and healthy controls. Fasting blood samples were analysed for blood glucose, insulin, high-sensitivity C-reactive protein and iron status...
December 2014: JPMA. the Journal of the Pakistan Medical Association
Robabeh Ghergherehchi, Afshin Habibzadeh
Iron overload is a common finding in chronically transfused β-thalassemia major (β-TM) patients with possible effect on β cell function and insulin resistance. In this study we aimed to evaluate glucose metabolism, insulin resistance and β cell function in β-TM patients. A total of 78 transfusion-dependent β-TM patients and 40 age and sex matched normal children were included. Oral glucose tolerance tests (OGTT) were performed in all subjects. Fasting plasma insulin level, insulin resistance index (IRI) and β cell function index (BFI) were also estimated...
2015: Hemoglobin
Samuel E Schriner, Steven Kuramada, Terry E Lopez, Stephanie Truong, Andrew Pham, Mahtab Jafari
Cinnamon is a spice commonly used worldwide to flavor desserts, fruits, cereals, breads, and meats. Numerous health benefits have been attributed to its consumption, including the recent suggestion that it may decrease blood glucose levels in people with diabetes. Insulin signaling is an integral pathway regulating the lifespan of laboratory organisms, such as worms, flies, and mice. We posited that if cinnamon truly improved the clinical signs of diabetes in people that it would also act on insulin signaling in laboratory organisms and increase lifespan...
December 2014: Experimental Gerontology
Juliana Félix-Silva, Thiago Souza, Rafael Barros Gomes Camara, Bárbara Cabral, Arnóbio Antônio Silva-Júnior, Ivanise Marina Moretti Rebecchi, Silvana Maria Zucolotto, Hugo Alexandre Oliveira Rocha, Matheus de Freitas Fernandes-Pedrosa
BACKGROUND: Jatropha gossypiifolia L. (Euphorbiaceae) is a medicinal plant largely used in folk medicine. Teas from the leaves are popularly used as an antithrombotic agent and the branches are frequently employed as a "thick blood" agent. Considering that the anticoagulant activity associated with antioxidant properties could be beneficial for various cardiovascular diseases, this study's aim is the evaluation of anticoagulant and antioxidant activities of J. gossypiifolia leaves, seeking new therapeutic purposes for this plant...
2014: BMC Complementary and Alternative Medicine
Wanxia Gao, Xueli Li, Zhonghong Gao, Hailing Li
Diabetic nephropathy is both a common and a severe complication of diabetes mellitus. Iron is an essential trace element. However, excess iron is toxic, playing a role in the pathogenesis of diabetic nephropathy. The present study aimed to determine the extent of the interaction between iron and type 2 diabetes in the kidney. Male rats were randomly assigned into four groups: control, iron (300-mg/kg iron dextran), diabetes (a single dose of intraperitoneal streptozotocin), and iron + diabetes group. Iron supplementation resulted in a higher liver iron content, and diabetic rats showed higher serum glucose compared with control rats, which confirmed the model as iron overload and diabetic...
September 2014: Biological Trace Element Research
Marcelo Betti Mascaro, Cristiane Miranda França, Kamilla F Esquerdo, Marx A N Lara, Nilsa S Y Wadt, Erna E Bach
This study evaluated the effect of the Agaricus sylvaticus (sun mushroom) on biochemical tests of the plasma and on the morphology of the pancreas in an experimental model of type I diabetes mellitus (DM1) induced by streptozotocin. One gram of dry A. sylvaticus was homogenized and mixed with the chow. Male Wistar rats were allocated as follows: normoglycemic control that received commercial chow; normoglycemic control group that received chow with A. sylvaticus; diabetic group that received commercial chow; and diabetic group that received chow with A...
2014: Evidence-based Complementary and Alternative Medicine: ECAM
Noha E Naem, Nawal M El-Sayed, Samia A Nossier, Azza A Abu Zeid
BACKGROUND AND OBJECTIVES: Deficiencies of protein, energy, and micronutrients are highly prevalent in developing countries and have major effects on pregnancy outcome. Low dietary intake is the most common reason for zinc deficiency. The present research is part of a larger double-blind randomized-controlled trial to evaluate the effect of zinc supplementation on the pregnancy outcome. The aim of the present study was to assess the zinc status and dietary intake of zinc and other macronutrients and micronutrients among pregnant women in Alexandria, Egypt...
April 2014: Journal of the Egyptian Public Health Association
André M N Silva, Paulo R H Sousa, João T S Coimbra, Natércia F Brás, Rui Vitorino, Pedro A Fernandes, Maria J Ramos, Maria Rangel, Pedro Domingues
The mechanisms involving iron toxicity in diabetes mellitus are not completely understood. However, the spontaneous reaction of reducing sugars with protein amino groups, known as glycation, has been shown to compromise the action of Tf (transferrin), the systemic iron transporter. In order to understand the structural alterations that impair its function, Tf was glycated in vitro and the modification sites were determined by MS. Iron binding to glycated Tf was assessed and a computational approach was conducted to study how glycation influences the iron-binding capacity of this protein...
July 1, 2014: Biochemical Journal
Thomas Nubila, Ernest O Ukaejiofo, Samuel O Ike, Elvis N Shu, Nkoyo I Nubila, Chioli P Chijioke, Ayodele C Ukaejiofo, Eghosa E Iyare, Chukwubuzor U Okwosa, Onyinye V Okwuowulu
BACKGROUND: The role of micronutrients and other predisposing factors associated with the aetiology of type 2 diabetes in Nigeria is not well established. The objectives of this study were to investigate predisposing factors associated with uncomplicated type 2 diabetes among a Nigerian adult population. METHODS: Predisposing factors associated with uncomplicated type 2 diabetes were investigated in 60 Igbo (a major tribe in Eastern Nigeria) adults aged 30-90 years...
April 2014: Transactions of the Royal Society of Tropical Medicine and Hygiene
Nadiah Ishak, Alexandra Tikhomirova, Stephen J Bent, Garth D Ehrlich, Fen Z Hu, Stephen P Kidd
BACKGROUND: Haemophilus influenzae colonizes the nasopharynx as a commensal. Strain-specific factors allow some strains to migrate to particular anatomical niches, such as the middle ear, bronchi or blood, and induce disease by surviving within the conditions present at these sites in the body. It is established that H. influenzae colonization and in some cases survival is highly dependent on their ability to form a biofilm. Biofilm formation is a key trait in the development of chronic infection by certain isolates...
2014: BMC Microbiology
Xu Zhang, Wei Zhang, Shwu-Fan Ma, Galina Miasniakova, Adelina Sergueeva, Tatiana Ammosova, Min Xu, Sergei Nekhai, Mehdi Nourai, Michael S Wade, Josef T Prchal, Joe G N Garcia, Roberto F Machado, Victor R Gordeuk
In congenital Chuvash polycythemia (CP), VHL(R200W) homozygosity leads to elevated hypoxia inducible factor (HIF) levels at normoxia. CP is often treated by phlebotomy resulting in iron deficiency, permitting us to examine the separate and synergistic effects of iron deficiency and HIF signaling on gene expression. We compared peripheral blood mononuclear cell gene expression profiles of eight VHL(R200W) homozygotes with 17 wildtype individuals with normal iron status and found 812 up-regulated and 2120 down-regulated genes at false discovery rate of 0...
January 2014: Blood Cells, Molecules & Diseases
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