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https://www.readbyqxmd.com/read/27913308/biodegradable-magnetic-silica-iron-oxide-nanovectors-with-ultra-large-mesopores-for-high-protein-loading-magnetothermal-release-and-delivery
#1
Haneen Omar, Jonas G Croissant, Kholod Alamoudi, Shahad Alsaiari, Ibrahim Alradwan, Majed A Majrashi, Dalaver H Anjum, Patricia Martins, Basem Moosa, Abdulaziz Almalik, Niveen M Khashab
The delivery of large cargos of diameter above 15nm for biomedical applications has proved challenging since it requires biocompatible, stably-loaded, and biodegradable nanomaterials. In this study, we describe the design of biodegradable silica-iron oxide hybrid nanovectors with large mesopores for large protein delivery in cancer cells. The mesopores of the nanomaterials spanned from 20 to 60nm in diameter and post-functionalization allowed the electrostatic immobilization of large proteins (e.g. mTFP-Ferritin, ~534kDa)...
November 29, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27903518/habituation-to-low-or-high-protein-intake-does-not-modulate-basal-or-postprandial-muscle-protein-synthesis-rates-a-randomized-trial
#2
Stefan Hm Gorissen, Astrid Mh Horstman, Rinske Franssen, Imre Wk Kouw, Benjamin T Wall, Nicholas A Burd, Lisette Cpgm de Groot, Luc Jc van Loon
BACKGROUND: Muscle mass maintenance is largely regulated by basal muscle protein synthesis rates and the ability to increase muscle protein synthesis after protein ingestion. To our knowledge, no previous studies have evaluated the impact of habituation to either low protein intake (LOW PRO) or high protein intake (HIGH PRO) on the postprandial muscle protein synthetic response. OBJECTIVE: We assessed the impact of LOW PRO compared with HIGH PRO on basal and postprandial muscle protein synthesis rates after the ingestion of 25 g whey protein...
November 30, 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27903298/meal-rich-in-carbohydrate-but-not-protein-or-fat-reveals-adverse-immunometabolic-responses-associated-with-obesity
#3
Ehsan Parvaresh Rizi, Sonia Baig, Muhammad Shabeer, Yvonne Teo, Shao Feng Mok, Tze Ping Loh, Faidon Magkos, Sam Virtue, Antonio Vidal-Puig, E Shyong Tai, Chin Meng Khoo, Sue-Anne Toh
BACKGROUND: Obesity-related insulin resistance is linked to inflammation. Immunometabolic function differs between lean and obese subjects, but whether macronutrient composition of ingested meals affects these responses is not well known. We examined the effects of a single meal rich in fat, protein, or carbohydrate on immunometabolic responses. METHODS: Nine lean insulin sensitive (LIS) men and 9 obese insulin resistant (OIR) men ingested high-carbohydrate (HC), high-fat (HF) or high-protein (HP) mixed meals in random order...
December 1, 2016: Nutrition Journal
https://www.readbyqxmd.com/read/27898909/protein-and-amino-acid-bioavailability-of-extruded-dog-food-with-protein-meals-of-different-quality-using-growing-mink-as-a-model
#4
M T Tjernsbekk, A-H Tauson, C F Matthiesen, Ø Ahlstrøm
The present study evaluated growing mink () as a model for dietary protein quality assessment of protein meals used in extruded dog foods. Three foods with similar CP content but of different protein quality were produced using different protein meals. The protein meals varied with respect to CP digestibility and AA composition and included lamb meal (LBM), poultry meal (PM), and fish meal (FM) with low, intermediate, and high protein quality, respectively. Nitrogen balance, BW gain, protein efficiency ratio (PER), and apparent total tract digestibility (ATTD) were used as measures of protein and AA bioavailability in growing mink...
September 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27898907/apparent-total-tract-macronutrient-digestibility-fecal-characteristics-and-fecal-fermentative-end-product-concentrations-of-healthy-adult-dogs-fed-bioprocessed-soy-protein
#5
A N Beloshapka, M R C de Godoy, K B Detweiler, M Newcomb, K H Ellegård, G C Fahey, K S Swanson
Animal proteins are commonly used in extruded dog foods. Plant-based proteins have a more consistent nutrient profile than animal sources but may contain antinutritional factors, including trypsin inhibitors and oligosaccharides. Bioprocessed soy protein (SP; HP-300; Hamlet Protein, Inc., Findlay, OH) is a processed soy-based product with low antinutritional factor concentrations and high protein quality. The objective was to evaluate the effects of SP on apparent total tract macronutrient digestibility, fecal characteristics, and fecal fermentative end products...
September 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27898811/de-novo-transcriptome-assembly-and-dynamic-spatial-gene-expression-analysis-in-red-clover
#6
Manohar Chakrabarti, Randy D Dinkins, Arthur G Hunt
Red clover ( L.) is a cool-season forage legume grown throughout the northeastern United States and is the most widely planted forage legume after alfalfa ( L.). Red clover provides high-value feed to the livestock because of high protein content and easy digestibility. To date, genomic resources for red clover are scarce. In the current study, a de novo transcriptome assembly of red clover was constructed representing different tissue types. The draft assembly consists of 37,565 contigs with N50 and average contig length of 1707 and 1262 bp, respectively...
July 2016: Plant Genome
https://www.readbyqxmd.com/read/27895003/effect-on-nitrogen-balance-thermogenesis-body-composition-satiety-and-circulating-branched-chain-amino-acid-levels-up-to-one-year-after-surgery-protocol-of-a-randomized-controlled-trial-on-dietary-protein-during-surgical-weight-loss
#7
Violeta Moizé, Xavier Pi-Sunyer, Josep Vidal, Patricia Miner, Yves Boirie, Blandine Laferrère
BACKGROUND: Bariatric surgery (BS), the most effective treatment for severe obesity, typically results in 40-50 kg weight loss in the year following the surgery. Beyond its action on protein metabolism, dietary protein intake (PI) affects satiety, thermogenesis, energy efficiency, and body composition (BC). However, the required amount of PI after surgical weight loss is not known. The current daily PI recommendation for diet-induced weight loss is 0.8 g/kg ideal body weight (IBW) per day, but whether this amount is sufficient to preserve fat-free mass during active surgical weight loss is unknown...
November 28, 2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27894094/met-expression-and-copy-number-status-in-clear-cell-renal-cell-carcinoma-prognostic-value-and-potential-predictive-marker
#8
Stephan Macher-Goeppinger, Martina Keith, Volker Endris, Roland Penzel, Katrin E Tagscherer, Sascha Pahernik, Markus Hohenfellner, Humphrey Gardner, Carsten Grüllich, Peter Schirmacher, Wilfried Roth
Multiple targeted therapy for advanced clear-cell renal cell carcinoma (RCC) has substantially improved patient outcome, but complete remission is uncommon and many tumors eventually develop resistance. Mechanistic, preclinical, and early clinical data highlight c-Met / hepatocyte growth factor receptor as a promising target for RCC therapeutic agents.We have examined MET expression, frequency of MET gene copy gains and MET gene mutation in a large, hospital-based series of renal cell carcinomas with long-term follow-up information...
November 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/27893064/effect-of-increased-enteral-protein-intake-on-growth-in-human-milk-fed-preterm-infants-a-randomized-clinical-trial
#9
Christoph Maas, Michaela Mathes, Christine Bleeker, Julia Vek, Wolfgang Bernhard, Cornelia Wiechers, Andreas Peter, Christian F Poets, Axel R Franz
Importance: Protein, supplied in currently available commercial fortifiers, may be inadequate to meet the requirements of very preterm infants; in addition, intraindividual and interindividual variability of human milk protein and energy content potentially contribute to unsatisfactory early postnatal growth. Objective: To determine effects on growth of different levels of enteral protein supplementation in predominantly human milk-fed preterm infants. Design, Setting, and Participants: This randomized clinical and partially blinded single-center trial was conducted in a neonatal tertiary referral center in Germany...
November 21, 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/27889602/toxicity-evaluation-and-initial-characterization-of-the-venom-of-a-colombian-latrodectus-sp
#10
Alexandra Rueda, Emilio Realpe, Alfredo Uribe
The genus Latrodectus has not been studied in Colombia even though it is medically important worldwide; there are three species for the country, this study focused on a non-identified species found in the Tatacoa Desert in the Huila Department. This research is the first approximation to the extraction, composition analysis and toxicity evaluation of the venom of a species of the genus Latrodectus in Colombia; and aims to evaluate the toxicity by the initial characterization of its venom. The venom extraction was accomplished with electrostimulation and total protein concentration was determined by the Lowry method and BCA assays from crude venom; with these methods, high protein concentration of the samples was measured...
November 23, 2016: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/27889387/diet-microbiome-interactions-in-health-are-controlled-by-intestinal-nitrogen-source-constraints
#11
Andrew J Holmes, Yi Vee Chew, Feyza Colakoglu, John B Cliff, Eline Klaassens, Mark N Read, Samantha M Solon-Biet, Aisling C McMahon, Victoria C Cogger, Kari Ruohonen, David Raubenheimer, David G Le Couteur, Stephen J Simpson
Diet influences health and patterns of disease in populations. How different diets do this and why outcomes of diets vary between individuals are complex and involve interaction with the gut microbiome. A major challenge for predicting health outcomes of the host-microbiome dynamic is reconciling the effects of different aspects of diet (food composition or intake rate) on the system. Here we show that microbial community assembly is fundamentally shaped by a dichotomy in bacterial strategies to access nitrogen in the gut environment...
November 15, 2016: Cell Metabolism
https://www.readbyqxmd.com/read/27888613/psmc2-is-up-regulated-in-osteosarcoma-and-regulates-osteosarcoma-cell-proliferation-apoptosis-and-migration
#12
Mingzhi Song, Yong Wang, Zhen Zhang, Shouyu Wang
Proteasome 26S subunit ATPase 2 (PSMC2) is a recently identified gene potentially associated with certain human carcinogenesis. However, the expressional correlation and functional importance of PSMC2 in osteosarcoma is still unclear. Current study was focused on elucidating the significance of PSMC2 on malignant behaviors in osteosarcoma including proliferation, apoptosis, colony formation, migration as well as invasion. The high protein levels of PSMC2 in osteosarcoma samples were identified by tissue microarrays analysis...
November 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27885970/cpt1a-gene-expression-in-peripheral-blood-mononuclear-cells-as-an-early-biomarker-of-diet-related-metabolic-alterations
#13
Rubén Díaz-Rúa, Andreu Palou, Paula Oliver
BACKGROUND: Research on biomarkers that provide early information about the development of future metabolic alterations is an emerging discipline. Gene expression analysis in peripheral blood mononuclear cells (PBMC) is a promising tool to identify subjects at risk of developing diet-related diseases. OBJECTIVE: We analysed PBMC expression of key energy homeostasis-related genes in a time-course analysis in order to find out early markers of metabolic alterations due to sustained intake of high-fat (HF) and high-protein (HP) diets...
2016: Food & Nutrition Research
https://www.readbyqxmd.com/read/27885677/chemical-composition-of-microalgae-heterochlorella-luteoviridis-and-dunaliella-tertiolecta-with-emphasis-on-carotenoids
#14
Andressa Bacalau Diprat, Tania Menegol, Juliana Ferreira Boelter, Ariane Zmozinski, Maria Goreti Rodrigues Vale, Eliseu Rodrigues, Rosane Rech
BACKGROUND: Microalgae have been used as food supplements due their high protein, polyunsaturated fatty acids and carotenoid contents. As different carotenoids have distinct properties, and carotenoid composition from microalgae were poorly explored in the literature, this study determined the complete carotenoid composition from two microalgae species, Heterochlorella luteoviridis and Dunaliella tertiolecta, using high-performance liquid chromatography coupled to diode array detector and a mass spectrometry (HPLC-DAD-MS(2) )...
November 24, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27867835/combined-13-c-assisted-metabolomics-and-metabolic-flux-analysis-reveals-the-impacts-of-glutamate-on-the-central-metabolism-of-high-%C3%AE-galactosidase-producing-pichia-pastoris
#15
Ping Liu, Mingzhi Huang, Menglei Guo, Jiangchao Qian, Weilu Lin, Ju Chu, Yingping Zhuang, Siliang Zhang
BACKGROUND: Pichia pastoris is a popular recombinant protein expression system for its accessibility of efficient gene manipulation and high protein production. Sufficient supply of precursors, energy, and redox cofactors is crucial for high recombinant protein production. In our present work, we found that the addition of glutamate improved the recombinant β-galactosidase (β-gal) production by P. pastoris G1HL. METHODS: To elucidate the impacts of glutamate on the central metabolism in detail, a combined (13)C-assisted metabolomics and (13)C metabolic flux analysis was conducted based on LC-MS/MS and GC-MS data...
2016: Bioresources and Bioprocessing
https://www.readbyqxmd.com/read/27865505/nitrogen-utilization-preweaning-nutrient-digestibility-and-growth-effects-of-holstein-dairy-calves-fed-2-amounts-of-a-moderately-high-protein-or-conventional-milk-replacer
#16
C E Chapman, T M Hill, D R Elder, P S Erickson
Studies have shown that calves fed milk replacers (MR) with crude protein (CP) concentrations greater than 20%, as typically found in conventional MR, have higher dry matter intakes (DMI) and greater average daily gains (ADG) but consume less starter, which can lead to stress during weaning and reduced rumen development. The greater amount of CP being fed to preweaned calves may alter their nitrogen (N) balance, and excess N may be excreted in the urine. The objective of this study was to determine N utilization in preweaned calves fed diets varying in the amount of CP and MR fed...
November 16, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27861962/quality-assessment-of-dried-okara-as-a-source-of-production-of-gluten-free-flour
#17
María V Ostermann-Porcel, Ana N Rinaldoni, Laura T Rodriguez-Furlán, Mercedes E Campderrós
BACKGROUND: Okara is a by-product of soymilk and of tofu elaboration which is rich in protein, fiber and vegetable oils as a source of gluten-free flour. In order to take advantage of the nutritional characteristics of Okara and to be able to determine an appropriate drying methodology, a microwave, a rotary dryer and freeze-drying were assessed. Furthermore, flour with an enzymatic treatment was characterized as well as its functional, physicochemical and textural properties. RESULTS: The results showed that the physiochemical characteristics of the flour were affected by the drying process, reaching adequate water content, high protein and fiber content...
November 9, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27861557/the-ability-of-a-non-egg-adapted-cell-like-a-h1n1-pdm09-virus-to-egg-adapt-at-ha-loci-other-than-222-and-223-and-its-effect-on-the-yield-of-viral-protein
#18
Carolyn Nicolson, Ruth Harvey, Othmar G Engelhardt, James S Robertson
Previous studies on influenza A(H1N1)pdm09 candidate vaccine viruses (CVVs) that had adapted to growth in embryonated chicken eggs by the acquisition of amino acid substitutions at HA positions 222 or 223 showed that improved protein yield could be conferred by additional amino acid substitutions in the haemagglutinin (HA) that arose naturally during passaging of the virus in eggs. In this study we investigated, by means of reverse genetics, the ability of a non-egg adapted (cell-like) A(H1N1)pdm09 virus to egg-adapt at HA loci other than 222/223, introducing amino acid substitutions previously identified as egg adaptations in pre-H1N1pdm09 H1N1 viruses and assessing their effect on protein yield and antigenicity...
2016: PloS One
https://www.readbyqxmd.com/read/27857027/determination-and-prediction-of-digestible-and-metabolizable-energy-concentrations-in-byproduct-feed-ingredients-fed-to-growing-pigs
#19
Ah Reum Son, Chan Sol Park, Beob Gyun Kim
Objective: An experiment was conducted to determine digestible energy (DE) and metabolizable energy (ME) of different byproduct feed ingredients fed to growing pigs, and to generate prediction equations for the DE and ME in feed ingredients. Methods: Twelve barrows with an initial mean body weight of 31.8 kg were individually housed in metabolism crates that were equipped with a feeder and a nipple drinker. A 12 × 10 incomplete Latin square design was employed with 12 dietary treatments, 10 periods, and 12 animals...
November 17, 2016: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/27855940/rheological-and-stability-aspects-of-dry-and-hydrothermally-heat-treated-aleurone-rich-wheat-milling-fraction
#20
Blanka Bucsella, Ágnes Takács, Walter von Reding, Urs Schwendener, Franka Kálmán, Sándor Tömösközi
Novel aleurone-rich wheat milling fraction developed and produced on industry scale is investigated. The special composition of the novel flour with high protein, dietary fiber and fat content results in a unique combination of the mixing and viscosity properties. Due to the high lipid concentration, the fraction is exposed to fast rancidity. Dry heat (100°C for 12min) and hydrothermal treatment processes (96°C for 6min with 0-20 L/h steam) were applied on the aleurone-rich flour to modify the technological properties...
April 1, 2017: Food Chemistry
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