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https://www.readbyqxmd.com/read/28805905/standardized-ileal-digestible-amino-acids-and-digestible-energy-contents-in-high-protein-distiller-s-dried-grains-with-solubles-fed-to-growing-pigs
#1
Y Rho, C Zhu, E Kiarie, C F M de Lange
Chemical composition and, therefore, potential nutritive value of corn distiller's dried grains with solubles (DDGS) is constantly evolving as the ethanol industry innovates processing techniques. We determined standardized ileal digestibility (SID) of AA (Exp. 1) and DE (Exp. 2) contents in high-protein (HP; >40% on a DM basis) DDGS samples. Two HP DDGS (HP-A and HP-B) samples and 1 conventional DDGS (CON) sample were selected for this study. Three semipurified corn starch-based diets (minimum 18% CP, as-fed basis) were formulated with DDGS as the sole source of AA...
August 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28803213/effect-of-salting-and-ripening-on-the-physicochemical-and-sensory-quality-of-goat-and-sheep-cured-legs
#2
Alfredo Teixeira, Aline Fernandes, Etelvina Pereira, Aristides Manuel, Sandra Rodrigues
Physicochemical and sensory characteristics of sheep and goat cured legs were evaluated. The pH values (5.7-5.8) and aw (0.87 and 0.83) found to be adequate to control meat deterioration, promoting safety and stability to shelf life of products with respect to microbial growth. The high protein (46.2 and 38.4%) and low fat (5.3 and 8.7%) percentages of the goat and sheep cured legs were the main evidence of the effect of salting and ripening processes. A low cholesterol content of 4.5% is particularly evident in sheep cured legs...
August 4, 2017: Meat Science
https://www.readbyqxmd.com/read/28795235/impact-of-seed-protein-alleles-from-three-soybean-sources-on-seed-composition-and-agronomic-traits
#3
Lillian F Brzostowski, Timothy I Pruski, James E Specht, Brian W Diers
Evaluation of seed protein alleles in soybean populations showed that an increase in protein concentration is generally associated with a decrease in oil concentration and yield. Soybean [Glycine max (L.) Merrill] meal is one of the most important plant-based protein sources in the world. Developing cultivars high in seed protein concentration and seed yield is a difficult task because the traits have an inverse relationship. Over two decades ago, a protein quantitative trait loci (QTL) was mapped on chromosome (chr) 20, and this QTL has been mapped to the same position in several studies and given the confirmed QTL designation cqSeed protein-003...
August 9, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/28794212/addition-of-rye-bran-and-pea-fiber-to-pork-meatballs-enhances-subjective-satiety-in-healthy-men-but-does-not-change-glycemic-or-hormonal-responses-a-randomized-crossover-meal-test-study
#4
Ursula Kehlet, Josephine Kofod, Jens J Holst, Christian Ritz, Margit D Aaslyng, Anne Raben
Background: The development of high-protein, fiber-rich foods targeting appetite control could be an efficient tool in obesity prevention.Objectives: We investigated whether ad libitum energy intake (EI), appetite, and metabolic markers in a meal context were affected by 1) fiber addition (rye bran and pea fiber) to pork meatballs, 2) the food matrix of the fiber (fiber meatballs compared with fiber bread), or 3) the protein source (animal compared with vegetable protein patties).Methods: In a crossover design, 40 healthy men [mean ± SD: body mass index (BMI; in kg/m(2)), 22...
August 9, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28792489/l-phenylalanine-modulates-gut-hormone-release-and-glucose-tolerance-and-suppresses-food-intake-through-the-calcium-sensing-receptor-in-rodents
#5
A Alamshah, E Spreckley, M Norton, J S Kinsey-Jones, A Amin, A Ramgulam, Y Cao, R Johnson, K Saleh, E Akalestou, Z Malik, N Gonzalez-Abuin, A Jomard, R Amarsi, A Moolla, P R Sargent, G W Gray, S R Bloom, K G Murphy
OBJECTIVE: High-protein diets (HPDs) are associated with greater satiety and weight loss than diets rich in other macronutrients. The exact mechanisms by which HPDs exert their effects are unclear. However, evidence suggests that the sensing of amino acids produced as a result of protein digestion may have a role in appetite regulation and satiety. We investigated the effects of l-phenylalanine (L-Phe) on food intake and glucose homeostasis in rodents. METHODS: We investigated the effects of the aromatic amino-acid and calcium-sensing receptor (CaSR) agonist l-phenylalanine (L-Phe) on food intake and the release of the gastrointestinal (GI) hormones peptide YY (PYY), glucagon-like peptide-1 (GLP-1) and ghrelin in rodents, and the role of the CaSR in mediating these effects in vitro and in vivo...
July 13, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28791293/differential-effects-of-high-protein-diets-derived-from-soy-and-casein-on-blood-brain-barrier-integrity-in-wild-type-mice
#6
Matthew Snelson, John C L Mamo, Virginie Lam, Corey Giles, Ryusuke Takechi
A number of studies report that a diet high in protein influences cognitive performance, but the results are inconsistent. Studies demonstrated that protein from different food sources has differential effects on cognition. It is increasingly recognized that the integrity of cerebrovascular blood-brain barrier (BBB) is pivotal for central nervous system function. However, to date, no studies have reported the effects of high-protein diets on BBB integrity. Therefore, in this study, the effects of diets enriched in casein or soy protein on BBB permeability were investigated...
2017: Frontiers in Nutrition
https://www.readbyqxmd.com/read/28782052/real-time-sensing-of-single-ligand-delivery-with-nanoaperture-integrated-microfluidic-devices
#7
W Elliott Martin, Ning Ge, Bernadeta R Srijanto, Emily Furnish, C Patrick Collier, Christine A Trinkle, Christopher I Richards
The measurement of biological events on the surface of live cells at the single-molecule level is complicated by several factors including high protein densities that are incompatible with single-molecule imaging, cellular autofluorescence, and protein mobility on the cell surface. Here, we fabricated a device composed of an array of nanoscale apertures coupled with a microfluidic delivery system to quantify single-ligand interactions with proteins on the cell surface. We cultured live cells directly on the device and isolated individual epidermal growth factor receptors (EGFRs) in the apertures while delivering fluorescently labeled epidermal growth factor...
July 31, 2017: ACS Omega
https://www.readbyqxmd.com/read/28780899/mapping-the-human-skeletal-muscle-proteome-progress-and-potential
#8
Daniele Capitanio, Manuela Moriggi, Cecilia Gelfi
Abtract Introduction: Human skeletal muscle represents 40% of our body mass and deciphering its proteome composition to further understand mechanisms regulating muscle function under physiological and pathological conditions has proved a challenge. The inter-individual variability, the presence of structurally and functionally different muscle types and the high protein dynamic range require carefully selected methodologies for the assessment of the muscle proteome. Furthermore, physiological studies are understandingly hampered by ethical issues related to biopsies on healthy subjects, making it difficult to recruit matched controls essential for comparative studies...
August 7, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28776163/characteristics-of-meningitis-following-transsphenoidal-endoscopic-surgery-a-case-series-and-a-systematic-literature-review
#9
Pasquale Pagliano, Chiara Caggiano, Tiziana Ascione, Domenico Solari, Giusy Di Flumeri, Luigi Maria Cavallo, Fabio Tortora, Paolo Cappabianca
BACKGROUND: Meningitis occurs in 0.8-1.5% of patients undergoing neurosurgery. The aim of the study was to evaluate the characteristics of meningitis after endoscopic endonasal transsphenoidal surgery (EETS) comparing the findings retrieved to those highlighted by literature search. MATERIALS AND METHODS: Patients treated by EETS during an 18-year period in the Department of Neurosurgery of 'Federico II' University of Naples were evaluated and included in the study if they fulfilled criteria for meningitis...
August 3, 2017: Infection
https://www.readbyqxmd.com/read/28765774/increase-in-dietary-protein-content-exacerbates-colonic-inflammation-and-tumorigenesis-in-azoxymethane-induced-mouse-colon-carcinogenesis
#10
Ka-Hee Tak, Eunyeong Ahn, Eunjung Kim
BACKGROUND/OBJECTIVE: The incidence of colorectal cancer (CRC) has been attributed to higher intake of fat and protein. However, reports on the relationship between protein intake and CRC are inconsistent, possibly due to the complexity of diet composition. In this study, we addressed a question whether alteration of protein intake is independently associated with colonic inflammation and colon carcinogenesis. MATERIALS/METHODS: Balb/c mice were randomly divided into 4 experimental groups: 20% protein (control, 20P, 20% casein/kg diet), 10% protein (10P, 10% casein/kg diet), 30% protein (30P, 30% casein/kg diet), and 50% protein (50P, 50% casein/kg diet) diet groups and were subjected to azoxymethane-dextran sodium sulfate induced colon carcinogenesis...
August 2017: Nutrition Research and Practice
https://www.readbyqxmd.com/read/28763030/the-binding-effect-of-proteins-on-medications-and-its-impact-on-electrochemical-sensing-antipsychotic-clozapine-as-a-case-study
#11
George E Banis, Thomas Winkler, Patricia Barton, Sheryl E Chocron, Eunkyoung Kim, Deanna L Kelly, Gregory F Payne, Hadar Ben-Yoav, Reza Ghodssi
Clozapine (CLZ), a dibenzodiazepine, is demonstrated as the optimal antipsychotic for patients suffering from treatment-resistant schizophrenia. Like many other drugs, understanding the concentration of CLZ in a patient's blood is critical for managing the patients' symptoms, side effects, and overall treatment efficacy. To that end, various electrochemical techniques have been adapted due to their capabilities in concentration-dependent sensing. An open question associated with electrochemical CLZ monitoring is whether drug-protein complexes (i...
August 1, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/28755991/optimization-of-high-concentration-endostatin-formulation-harmonization-of-excipients-contributions-on-colloidal-and-conformational-stabilities
#12
Shujing Wang, Xinyi Zhang, Guoliang Wu, Zhou Tian, Feng Qian
Recently, increasing research efforts have been devoted into developing high-concentration protein drugs for subcutaneous injection, especially for those with short half-lives and high-dose requirement. Proteins at high concentrations normally present increased colloidal and structural instability, such as aggregation, fibrillation and gelation, which significantly challenges the high-concentration formulation development of protein drugs. Here we used endostatin, a 20kD recombinant protein, as a model drug for high-concentration formulation optimization...
July 26, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28747486/modifying-the-dietary-carbohydrate-to-protein-ratio-alters-the-postprandial-macronutrient-oxidation-pattern-in-liver-of-ampk-deficient-mice
#13
Tristan Chalvon-Demersay, Patrick C Even, Catherine Chaumontet, Julien Piedcoq, Benoit Viollet, Claire Gaudichon, Daniel Tomé, Marc Foretz, Dalila Azzout-Marniche
Background: Hepatic AMP-activated kinase (AMPK) activity is sensitive to the dietary carbohydrate-to-protein ratio. However, the role of AMPK in metabolic adaptations to variations in dietary macronutrients remains poorly understood.Objective: The objective of this study was to determine the role of hepatic AMPK in the adaptation of energy metabolism in response to modulation of the dietary carbohydrate-to-protein ratio.Methods: Male 7-wk-old wild-type (WT) and liver AMPK-deficient (knockout) mice were fed either a normal-protein and normal-carbohydrate diet (NP-NC; 14% protein, 76% carbohydrate on an energy basis), a low-protein and high-carbohydrate diet (LP-HC; 5% protein, 85% carbohydrate), or a high-protein and low-carbohydrate diet (HP-LC; 55% protein, 35% carbohydrate) for 3 wk...
July 26, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28744731/plant-community-chemical-composition-influences-trembling-aspen-populus-tremuloides-intake-by-sheep
#14
Kristen Y Heroy, Samuel B St Clair, Elizabeth A Burritt, Juan J Villalba
Nutrients and plant secondary compounds in aspen (Populus tremuloides) may interact with nutrients in the surrounding vegetation to influence aspen use by herbivores. Thus, this study aimed to determine aspen intake and preference by sheep in response to supplementary nutrients or plant secondary compounds (PSC) present in aspen trees. Thirty-two lambs were randomly assigned to one of four molasses-based supplementary feeds to a basal diet of tall fescue hay (N = 8) during three experiments. The supplements were as follows: (1) high-protein (60% canola meal), (2) a PSC (6% quebracho tannins), (3) 25% aspen bark, and (4) control (100% molasses)...
July 25, 2017: Journal of Chemical Ecology
https://www.readbyqxmd.com/read/28743557/a-high-fat-high-protein-diet-attenuates-the-negative-impact-of-casein-induced-chronic-inflammation-on-testicular-steroidogenesis-and-sperm-parameters-in-adult-mice
#15
Jing-Lu Zhao, Yu-Yun Zhao, Wei-Jie Zhu
The interaction between obesity and chronic inflammation has been studied. Diet-induced obesity or chronic inflammation could reduce the testicular functions of males. However, the mechanism underlying the reproductive effects of fattening foods in males with or without chronic inflammation still needs further discussion. This study was aimed to investigate the effects of high-fat, high-protein diet on testicular steroidogenesis and sperm parameters in adult mice under physiological and chronic inflammatory conditions...
July 22, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28740977/effects-of-addition-of-hydrocolloids-on-the-textural-and-structural-properties-of-high-protein-intermediate-moisture-food-model-systems-containing-sodium-caseinate
#16
J Li, Y Wu, Y Ma, N Lu, J M Regenstein, P Zhou
High-protein intermediate moisture food (HPIMF) containing sodium caseinate (NaCN) often gave a harder texture compared with that made from whey proteins or soy proteins, due to the aggregation of protein particles. The objectives of this study were to explore whether the addition of hydrocolloids could soften the texture and illustrate the possible mechanism. Three kinds of hydrocolloids, xanthan gum, κ-carrageenan, and gum arabic were chosen, and samples including of these three kinds of hydrocolloids were studied through texture analysis using a TPA test and microstructure observation by confocal laser scanning microscopy (CLSM) and scanning electron microscopy (SEM)...
August 1, 2017: Food & Function
https://www.readbyqxmd.com/read/28740306/comparative-study-of-the-quality-characteristics-of-defatted-soy-flour-treated-by-supercritical-carbon-dioxide-and-organic-solvent
#17
Sung-Won Kang, M Shafiur Rahman, Ah-Na Kim, Kyo-Yeon Lee, Chan-Yang Park, William L Kerr, Sung-Gil Choi
Defatted soy flour is a potential source of food protein, amino acids, ash and isoflavones. The supercritical carbon dioxide (SC-CO2) and a traditional organic solvent extraction methods were used to remove fat from soy flour, and the quality characteristics of a control soy flour (CSF), defatted soy flour by SC-CO2 (DSFSC-CO2) and defatted soy flour by an organic solvent (DSF-OS) were compared. The SC-CO2 process was carried out at a constant temperature of 45 °C, and a pressure of 40 MPa for 3 h with a CO2 flow rate of 30 g/min...
July 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28735580/high-protein-goat-s-milk-diet-identified-through-newborn-screening-clinical-warning-of-a-potentially-dangerous-dietetic-practice
#18
Evelina Maines, Giorgia Gugelmo, Elisa Tadiotto, Angelo Pietrobelli, Natascia Campostrini, Andrea Pasini, Florina Ion-Popa, Monica Vincenzi, Francesca Teofoli, Marta Camilot, Andrea Bordugo
OBJECTIVE: Breast-feeding is an unequalled way of providing optimal food for infants' healthy growth and development and the WHO recommends that infants should be exclusively breast-fed for the first 6 months of life. For mothers who are unable to breast-feed or who decide not to, infant formulas are the safest alternative. Despite recommendations, it is possible that parents make potentially harmful nutritional choices for their children because of cultural beliefs or misinformation on infant nutrition...
July 24, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28731622/mechanistic-modeling-based-pat-implementation-for-ion-exchange-process-chromatography-of-charge-variants-of-monoclonal-antibody-products
#19
Vijesh Kumar, Anurag S Rathore
Process chromatography is typically used to remove product related impurities and variants that have very similar physicochemical properties to the product. Baseline separation may not be achieved in most cases due to high protein loading and thus, pooling of the elution peak can be challenging for maximizing yield and achieving consistency in product quality. Batch-to-batch variability in quality of the feed material also occurs in commercial manufacturing. Mechanistic modeling of process chromatography, though non-trivial, can be an enabler for implementation of Process Analytical Technology...
July 21, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28728000/tailor-made-purified-human-platelet-lysate-concentrated-in-neurotrophins-for-treatment-of-parkinson-s-disease
#20
Ming-Li Chou, Joe-Wei Wu, Flore Gouel, Aurélie Jonneaux, Kelly Timmerman, Ting-Yi Renn, Charlotte Laloux, Hung-Ming Chang, Liang-Tzung Lin, Jean-Christophe Devedjian, David Devos, Thierry Burnouf
Human platelet lysates (PLs), which contain multiple neurotrophins, have been proposed for treating neurodegenerative disorders, including Parkinson's disease (PD). However, current PLs suspended in plasma have high protein content and contain fibrinogen/fibrin and, following activation, also proteolytic and thrombogenic enzymes. Upon brain administration, such PLs may saturate the cerebrospinal fluid and exert neurotoxicity. We assessed whether purified PLs, concentrated in neurotrophins, protected dopaminergic neurons in PD models...
October 2017: Biomaterials
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