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18-FDG endocarditis

A Roque, M N Pizzi, H Cuéllar-Calàbria, S Aguadé-Bruix
PURPOSE OF REVIEW: This article reviews the current imaging role of (18)F-fluordeoxyglucose positron emission computed tomography ((18)F-FDG-PET/CT) combined with cardiac CT angiography (CTA) in infective endocarditis and discusses the strengths and limitations of this technique. RECENT FINDINGS: The diagnosis of infective endocarditis affecting prosthetic valves and intracardiac devices is challenging because echocardiography and, therefore, the modified Duke criteria have well-recognized limitations in this clinical scenario...
February 2017: Current Cardiology Reports
Trine K Lauridsen, Kasper K Iversen, Nikolaj Ihlemann, Philip Hasbak, Annika Loft, Anne K Berthelsen, Anders Dahl, Danijela Dejanovic, Elisabeth Albrecht-Beste, Jann Mortensen, Andreas Kjær, Henning Bundgaard, Niels Eske Bruun
The extra-cardiac work-up in infective endocarditis (IE) comprises a search for primary and secondary infective foci. Whether (18)FDG-PET/CT or WBC-SPECT/CT is superior in detection of clinically relevant extra-cardiac manifestations in IE is unexplored. The objectives of this study were to identify the numbers of positive findings detected by each imaging modality, to evaluate the clinical relevance of these findings and to define the reproducibility for extra-cardiac foci in patients with definite IE. Each modality was evaluated for numbers and location of positive extra-cardiac foci in patients with definite IE...
January 3, 2017: International Journal of Cardiovascular Imaging
Anna Gomes, Andor W J M Glaudemans, Daan J Touw, Joost P van Melle, Tineke P Willems, Alexander H Maass, Ehsan Natour, Niek H J Prakken, Ronald J H Borra, Peter Paul van Geel, Riemer H J A Slart, Sander van Assen, Bhanu Sinha
Sensitivity and specificity of the modified Duke criteria for native valve endocarditis are both suboptimal, at approximately 80%. Diagnostic accuracy for intracardiac prosthetic material-related infection is even lower. Non-invasive imaging modalities could potentially improve diagnosis of infective endocarditis; however, their diagnostic value is unclear. We did a systematic literature review to critically appraise the evidence for the diagnostic performance of these imaging modalities, according to PRISMA and GRADE criteria...
January 2017: Lancet Infectious Diseases
Jean-François Sarrazin, François Philippon, Mikaël Trottier, Michel Tessier
Cardiovascular implantable electronic device (CIED) infection and prosthetic valve endocarditis (PVE) remain a diagnostic challenge. Cardiac imaging plays an important role in the diagnosis and management of patients with CIED infection or PVE. Over the past few years, cardiac radionuclide imaging has gained a key role in the diagnosis of these patients, and in assessing the need for surgery, mainly in the most difficult cases. Both (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) and radiolabelled white blood cell single-photon emission computed tomography/computed tomography (WBC SPECT/CT) have been studied in these situations...
September 26, 2016: World Journal of Cardiology
Daniel Juneau, Fernanda Erthal, Atif Alzahrani, Ali Alenazy, Pablo B Nery, Rob S Beanlands, Benjamin J Chow
Cardiac inflammatory disorders, either primarily cardiac or secondary to a systemic process, are associated with significant morbidity and/or mortality. Their diagnosis can be challenging, especially due to significant overlap in their clinical presentation with other cardiac diseases. Recent publications have investigated the potential diagnostic role of positron emission tomography (PET) imaging in these patients. Most of the available literature is focused on Fluorine-18 fluorodeoxyglucose (FDG), a tracer which has already demonstrated its use in other inflammatory and infectious processes...
December 2016: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Ana Jiménez-Ballvé, María Jesús Pérez-Castejón, Roberto C Delgado-Bolton, Cristina Sánchez-Enrique, Isidre Vilacosta, David Vivas, Carmen Olmos, Manuel E Fuentes Ferrer, José L Carreras-Delgado
PURPOSE: The diagnosis of prosthetic valve (PV) infective endocarditis (IE) and infection of cardiac implantable electronic devices (CIEDs) remains challenging. The aim of this study was to assess the usefulness of (18)F-FDG PET/CT in these patients and analyse the interpretation criteria. METHODS: We included 41 patients suspected of having IE by the Duke criteria who underwent (18)F-FDG PET/CT. The criteria applied for classifying the findings as positive/negative for IE were: (a) visual analysis of only PET images with attenuation-correction (AC PET images); (b) visual analysis of both AC PET images and PET images without AC (NAC PET images); (c) qualitative analysis of NAC PET images; and (d) semiquantitative analysis of AC PET images...
December 2016: European Journal of Nuclear Medicine and Molecular Imaging
S Aguadé-Bruix, M N Pizzi, A Roque, H Cuellar Calabria, N Fernández-Hidalgo, M T González Alujas
No abstract text is available yet for this article.
January 2017: Revista Española de Medicina Nuclear e Imagen Molecular
Ulises Granados, David Fuster, Juan M Pericas, Jaime Llopis, Salvador Ninot, Eduard Quintana, Manel Almela, Carlos Pare, Jose M Tolosana, Carlos Falces, Asuncion Moreno, Francesca Pons, Francisco Lomeña, Jose M Miro
: Early diagnosis of infective endocarditis (IE) is based on the yielding of blood cultures and echocardiographic findings. However, they have limitations and sometimes the diagnosis is inconclusive, particularly in patients with prosthetic valves (PV) and implantable cardiac electronic devices (ICED). The primary aim of this study was to evaluate the diagnostic accuracy of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) in patients with suspected IE an ICED infection...
June 3, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
B Rodriguez-Alfonso, I Zegri, J Mucientes Rasilla, A Forteza, D Petite, A Ramos Martinez
No abstract text is available yet for this article.
November 2016: Revista Española de Medicina Nuclear e Imagen Molecular
Sana Amraoui, Ghoufrane Tlili, Manav Sohal, Laurence Bordenave, Pierre Bordachar
BACKGROUND: 18-Fluorodeoxyglucose positron emission tomography/computerized tomography (FDG PET/CT) scanning has recently been proposed as a diagnostic tool for lead endocarditis (LE). OBJECTIVE: FDG PET/CT might be also useful to localize associated septic emboli in patients with LE. CASE PRESENTATION: We report an interesting case of a LE patient with a prosthetic aortic valve in whom a trans-esophageal echocardiogram did not show associated aortic endocarditis...
May 5, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Sonja van Roeden, Hans Hartog, Vivian Bongers, Steven Thijsen, Sanjay Sankatsing
Abiotrophia species are relatively slow growing pathogens, which may be present as commensal flora. However, invasive infections are frequently reported, like endocarditis, septic arthritis, osteomyelitis, and many other types of infection. In this case report we describe a 65-year-old male patient with an intracardiac device- (ICD-) lead infection caused by Abiotrophia defectiva. Diagnosis was confirmed by (18)F-FDG-PET scanning. This is remarkable, since Abiotrophia defectiva is a slow growing pathogen causing low-grade infections...
2016: Case Reports in Cardiology
James Patrick Buteau, Jacques Morais, Khun Visith Keu
No abstract text is available yet for this article.
March 21, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Sana Amraoui, Ghoufrane Tlili, Manav Sohal, Benjamin Berte, Elif Hindié, Philippe Ritter, Sylvain Ploux, Arnaud Denis, Nicolas Derval, Christopher A Rinaldi, Charles Cazanave, Pierre Jais, Michel Haissaguerre, Laurence Bordenave, Pierre Bordachar
OBJECTIVES: The aim of this study was to investigate the role of 18-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) scanning in identifying septic embolism in patients with lead endocarditis. BACKGROUND: Lead endocarditis may be associated with septic embolism, in which case the administration mode, type, and duration of antibiotic therapy must be adapted. However, diagnosis can be challenging: magnetic resonance imaging (MRI) cannot be performed in the vast majority of patients with cardiac implantable electronic devices (CIEDs)...
March 2016: JACC. Cardiovascular Imaging
A Martínez-Esteve, F J García-Gómez, I Acevedo-Báñez
No abstract text is available yet for this article.
August 2016: Revista Clínica Española
David Chieng, Johan Janssen, Susan Benson, Jurgen Passage, Nat Lenzo
Chronic Q fever endocarditis is a rare but important infection associated with risk of morbidity and mortality. Echocardiography rarely visualises the vegetative lesion. We describe the first Australian report of chronic Q fever aortic valve endocarditis confirmed with the use of 18 -FDG PET/ CT scan. Following valvular replacement, the patient had ongoing high serological titres despite active treatment and he was managed with yearly serial PET/ CT scan to confirm the absence of active infection. The utility of serial PET /CT scan imaging as a follow-up management strategy has not been described in the literature previously and should be investigated further...
February 2016: Heart, Lung & Circulation
María N Pizzi, Albert Roque, Nuria Fernández-Hidalgo, Hug Cuéllar-Calabria, Ignacio Ferreira-González, María T Gonzàlez-Alujas, Gerard Oristrell, Laura Gracia-Sánchez, Juan J González, José Rodríguez-Palomares, Manuel Galiñanes, Olga Maisterra-Santos, David Garcia-Dorado, Joan Castell-Conesa, Benito Almirante, Santiago Aguadé-Bruix, Pilar Tornos
BACKGROUND: The diagnosis of infective endocarditis (IE) in prosthetic valves and intracardiac devices is challenging because both the modified Duke criteria (DC) and echocardiography have limitations in this population. The added value of (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET)/computed tomography (CT) and (18)F-FDG PET/CT angiography (PET/CTA) was evaluated in this complex scenario at a referral center with a multidisciplinary IE unit. METHODS AND RESULTS: Ninety-two patients admitted to our hospital with suspected prosthetic valve or cardiac device IE between November 2012 and November 2014 were prospectively included...
September 22, 2015: Circulation
Ismet Sarikaya
Routine use of cardiac positron emission tomography (PET) applications has been increasing but has not replaced cardiac single-photon emission computerized tomography (SPECT) studies yet. The majority of cardiac PET tracers, with the exception of fluorine-18 fluorodeoxyglucose (18F-FDG), are not widely available, as they require either an onsite cyclotron or a costly generator for their production. 18F-FDG PET imaging has high sensitivity for the detection of hibernating/viable myocardium and has replaced Tl-201 SPECT imaging in centers equipped with a PET/CT camera...
October 2015: Nuclear Medicine Communications
Anders Dahl, Bente K Schaadt, Eric Santoni-Rugiu, Niels E Bruun
We present a 54-year-old woman with systemic lupus erythematosus (SLE), fever, pericardial effusion and a mitral valve vegetation. (18)F-Fluorodesoxyglucose positron emission tomography CT ((18)F-FDG-PET-CT) showed very high accumulation of the isotope at the mitral valve. The patient underwent cardiothoracic surgery and pathologic examinations showed characteristic morphology of Libman-Sacks vegetations. All microbiological examinations including blood cultures, microscopy, culture and 16s PCR of the valve were negative and the diagnosis of Libman-Sacks endocarditis was convincing...
April 2015: Infectious Diseases
François Rouzet, Renata Chequer, Khadija Benali, Laurent Lepage, Walid Ghodbane, Xavier Duval, Bernard Iung, Alec Vahanian, Dominique Le Guludec, Fabien Hyafil
UNLABELLED: Echocardiography plays a key role in the diagnosis of infective endocarditis (IE) but can be inconclusive in patients in whom prosthetic valve endocarditis (PVE) is suspected. The incremental diagnostic value of (18)F-FDG PET and radiolabeled leukocyte scintigraphy in IE patients has already been reported. The aim of this study was to compare the respective performance of (18)F-FDG PET and leukocyte scintigraphy for the diagnosis of PVE in 39 patients. METHODS: (18)F-FDG PET and leukocyte scintigraphy were performed on 39 consecutive patients admitted because of clinically suspected PVE and inconclusive echocardiography results...
December 2014: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Alessandra Ricciardi, Pasquale Sordillo, Laura Ceccarelli, Gaetano Maffongelli, Giorgio Calisti, Barbara Di Pietro, Cristiana Ragano Caracciolo, Orazio Schillaci, Antonio Pellegrino, Luigi Chiariello, Massimo Andreoni, Loredana Sarmati
OBJECTIVES: To evaluate the role of 18-fluoro-2-deoxyglucose positron emission tomography-computed tomography ((18)F-FDG-PET-CT) in the diagnosis of infectious endocarditis (IE). METHODS: We retrospectively examined 27 consecutive patients who were admitted to the Infectious Diseases Department of Tor Vergata University Hospital between 2009 and 2013 with a suspicion of IE. The final IE diagnosis was defined according to the modified Duke criteria, and the microbiological and diagnostic results were collected for each patient...
November 2014: International Journal of Infectious Diseases: IJID
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