keyword
MENU ▼
Read by QxMD icon Read
search

Dose escalation

keyword
https://www.readbyqxmd.com/read/29031170/a-dose-escalation-study-of-bi-daily-once-weekly-oral-docetaxel-either-as-modradoc001-or-modradoc006-combined-with-ritonavir
#1
Vincent A de Weger, Frederik E Stuurman, Jeroen J M A Hendrikx, Johannes J Moes, Emilia Sawicki, Alwin D R Huitema, Bastiaan Nuijen, Bas Thijssen, Hilde Rosing, Marianne Keessen, Marja Mergui-Roelvink, Jos H Beijnen, Jan H M Schellens, Serena Marchetti
INTRODUCTION: Two solid dispersions of docetaxel (denoted ModraDoc001 capsule and ModraDoc006 tablet (both 10 mg)) were co-administered with 100 mg ritonavir (/r) and investigated in a bi-daily once weekly (BIDW) schedule. Safety, maximum tolerated dose (MTD), pharmacokinetics (PK) and preliminary activity were explored. METHODS: Adult patients with metastatic solid tumours were included in two dose-escalation arms. PK sampling was performed during the first week and the second or third week...
October 11, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29028616/simultaneous-determination-of-a-novel-c-met-axl-dual-target-small-molecule-inhibitor-bpi-9016m-and-its-metabolites-in-human-plasma-by-liquid-chromatography-tandem-mass-spectrometry-application-in-a-pharmacokinetic-study-in-chinese-advanced-solid-tumor-patients
#2
Xinge Cui, Xin Zheng, Ji Jiang, Fenlai Tan, Lieming Ding, Pei Hu
BPI-9016M is a novel dual-target small-molecule inhibitor targeting c-Met and AXL, which was developed by Betta Pharmaceuticals Co., Ltd (Hangzhou, China). It has great potential in the treatment of advanced cancer. A high throughput quantitation method, based on liquid chromatography-tandem mass spectrometry, was developed and validated for the simultaneous determination of BPI-9016M and its main metabolite, M1 and M2-2, in human plasma with a sample preparation method of precipitation of protein. Liquid chromatographic separation was performed with a gradient elution of formic acid-10mM ammonium acetate aqueous solution (1:1000, v/v) and acetonitrile at a flow rate of 0...
October 8, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29025851/investigating-bordetella-pertussis-colonisation-and-immunity-protocol-for-an-inpatient-controlled-human-infection-model
#3
Hans de Graaf, Diane Gbesemete, Andrew R Gorringe, Dimitri A Diavatopoulos, Kent E Kester, Saul N Faust, Robert C Read
INTRODUCTION: We summarise an ethically approved protocol for the development of an experimental human challenge colonisation model. Globally Bordetella pertussis is one of the leading causes of vaccine-preventable death. Many countries have replaced whole cell vaccines with acellular vaccines over the last 20 years during which pertussis appears to be resurgent in a number of countries in the developed world that boast high immunisation coverage. The acellular vaccine provides relatively short-lived immunity and, in contrast to whole cell vaccines, may be less effective against colonisation and subsequent transmission...
October 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/29024786/neurobiological-correlates-of-pain-avoidance-like-behavior-in-morphine-dependent-and-non-dependent-rats
#4
Amanda R Pahng, Rod I Paulsen, M Adrienne McGinn, Kimberly N Edwards, Scott Edwards
Repeated use of opioids can lead to the development of analgesic tolerance and dependence. Additionally, chronic opioid exposure can cause a paradoxical emergence of heightened pain sensitivity to noxious stimuli, termed hyperalgesia, which may drive continued or escalated use of opioids to manage worsening pain symptoms. Opioid-induced hyperalgesia has traditionally been measured in rodents via reflex-based assays, including the von Frey method. To better model the cognitive/motivational dimension of pain in a state of opioid dependence and withdrawal, we employed a recently developed non-reflex-based method for measuring pain avoidance-like behavior in animals (mechanical conflict avoidance test)...
October 9, 2017: Neuroscience
https://www.readbyqxmd.com/read/29023527/dose-escalated-radiotherapy-for-unresectable-or-locally-recurrent-pancreatic-cancer-dose-volume-analysis-toxicity-and-outcome-of-28-consecutive-patients
#5
Sebastian Zschaeck, Bibiana Blümke, Peter Wust, David Kaul, Marcus Bahra, Hanno Riess, Fritz Klein, Marianne Sinn, Uwe Pelzer, Volker Budach, Pirus Ghadjar
PURPOSE: The role of radiotherapy for unresectable pancreatic cancer is controversial. A benefit of additional radiotherapy is supported by some observations. A dose-effect relationship was recently found by dose escalation employing image guided and intensity modulated radiotherapy. METHODS: We retrospectively evaluated 28 consecutive patients, all with history of extensive prior therapies for unresectable locally advanced/ recurrent pancreatic cancer (LAPC/LRPC)...
2017: PloS One
https://www.readbyqxmd.com/read/29022484/prognostic-implication-of-simultaneous-anemia-and-lymphopenia-during-concurrent-chemoradiotherapy-in-cervical-squamous-cell-carcinoma
#6
Oyeon Cho, Mison Chun, Young-Taek Oh, O Kyu Noh, Suk-Joon Chang, Hee-Sug Ryu, Eun Ju Lee
Radioresistance often leads to poor survival in concurrent chemoradiotherapy-treated cervical squamous cell carcinoma, and reliable biomarkers can improve prognosis. We compared the prognostic potential of hemoglobin, absolute neutrophil count, and absolute lymphocyte count with that of squamous cell carcinoma antigen in concurrent chemoradiotherapy-treated squamous cell carcinoma. We analyzed 152 patients with concurrent chemoradiotherapy and high-dose-rate intracavitary brachytherapy-treated cervical squamous cell carcinoma...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29018897/lack-of-evidence-that-soluble-urate-directly-influences-bone-remodelling-a-laboratory-and-clinical-study
#7
Nicola Dalbeth, Bregina Pool, Ashika Chhana, Jian-Ming Lin, Mei Lin Tay, Paul Tan, Karen E Callon, Dorit Naot, Anne Horne, Jill Drake, Gregory D Gamble, Ian R Reid, Andrew Grey, Lisa K Stamp, Jillian Cornish
INTRODUCTION: Numerous observational studies have reported that serum urate concentration positively correlates with bone density and reduced risk of fractures. The aim of this study was to examine whether soluble urate directly influences bone remodelling. METHODS: In laboratory studies, the in vitro effects of soluble urate were examined in osteoclast, osteoblast and osteocyte assays at a range of urate concentrations consistent with those typically observed in humans (up to 0...
October 10, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/29018537/safety-pharmacokinetics-and-pharmacodynamics-of-amg-811-an-anti-interferon-%C3%AE-monoclonal-antibody-in-sle-subjects-without-or-with-lupus-nephritis
#8
Michael J Boedigheimer, David A Martin, Zahir Amoura, Jorge Sánchez-Guerrero, Juanita Romero-Diaz, Alan Kivitz, Cynthia Aranow, Tak Mao Chan, Yip Boon Chong, Kit Chiu, Christine Wang, Winnie Sohn, Gregory E Arnold, Michael A Damore, Andrew A Welcher, Barbara A Sullivan, Brian L Kotzin, James B Chung
OBJECTIVE: To evaluate safety, pharmacokinetics and pharmacodynamics of anti-interferon (IFN)-γ monoclonal antibody AMG 811 in subjects with SLE without or with lupus nephritis (LN). METHODS: In this phase Ib, randomised, multiple-dose escalation study (NCT00818948), subjects without LN were randomised to subcutaneous AMG 811 (6, 20 or 60 mg) or placebo and subjects with LN were randomised to subcutaneous AMG 811 (20, 60 or 120 mg) or placebo every four weeks for three total doses...
2017: Lupus Science & Medicine
https://www.readbyqxmd.com/read/29018077/efficacy-of-venetoclax-as-targeted-therapy-for-relapsed-refractory-t-11-14-multiple-myeloma
#9
Shaji Kumar, Jonathan L Kaufman, Cristina Gasparetto, Joseph Mikhael, Ravi Vij, Brigitte Pegourie, Lofti Benboubker, Thierry Facon, Martine Amiot, Philippe Moreau, Elizabeth A Punnoose, Stefanie Alzate, Martin Dunbar, Tu Xu, Suresh K Agarwal, Sari Heitner Enschede, Joel D Leverson, Jeremy A Ross, Paulo C Maciag, Maria Verdugo, Cyrille Touzeau
Venetoclax is a selective, orally bioavailable BCL-2 inhibitor that induces cell death in MM cells, particularly in those harboring t(11;14), which express high levels of BCL-2 relative to BCL-XL and MCL-1. In this phase I study, patients with relapsed/refractory MM received venetoclax monotherapy. After a 2-week lead-in with weekly dose escalation, daily venetoclax was given at 300, 600, 900, or 1200 mg in dose-escalation cohorts and 1200 mg in the safety expansion. Dexamethasone could be added upon progression during treatment...
October 10, 2017: Blood
https://www.readbyqxmd.com/read/29016893/efficacy-safety-and-feasibility-of-the-morphine-microdose-method-in-community-based-clinics
#10
Denise M Wilkes, Susan J Orillosa, Erik C Hustak, Courtney G Williams, Gulshan R Doulatram, Daneshvari R Solanki, Eduardo A Garcia, Li-Yen M Huang
Objectives: The goal of this study was to assess the success of the morphine microdose method in a community pain clinic setting by monitoring follow-up frequency, dose escalation, and monotherapy/polytherapy ratio. The morphine microdose method involves a pretrial reduction or elimination of systemic opioids followed by a period of abstinence. Intrathecal (IT) morphine is then started at doses of less than 0.2 mg per day. Systemic opioid abstinence is then continued after pump implant and IT morphine monotherapy...
June 13, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28993435/impact-of-intercurrent-illness-on-calcium-homeostasis-in-children-with-hypoparathyroidism-a-case-series
#11
A Chinoy, M Skae, A Babiker, D Kendall, M Z Mughal, R Padidela
BACKGROUND: Hypoparathyroidism is characterised by hypocalcaemia, and standard management is with an active vitamin D analogue and adequate oral calcium intake (dietary and/or supplements). Little is described in the literature about the impact of intercurrent illnesses on calcium homeostasis in children with hypoparathyroidism. METHODS: We describe three children with hypoparathyroidism in whom intercurrent illnesses led to hypocalcaemia and escalation of treatment with alfacalcidol (1-hydroxycholecalciferol) and calcium supplements...
November 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28993415/targeting-either-gh-or-igf-i-during-somatostatin-analogue-treatment-in-patients-with-acromegaly-a-randomized-multicentre-study
#12
Jakob Dal, Marianne Klose, Ansgar Heck, Marianne Skovsager Andersen, Caroline Kistorp, Eigil H Nielsen, Jens Bollerslev, Ulla Feldt-Rasmussen, Jens Otto L Jorgensen
CONTEXT: Discordant GH and IGF-I values are frequent in acromegaly. The clinical significance and its dependence on treatment modality and of glucose-suppressed GH (GHnadir) measurements remain uncertain. OBJECTIVE: To evaluate the effects of targeting either IGF-I or GH during somatostatin analog (SA) treatment. PATIENTS AND METHODS: 84 patients with controlled acromegaly after surgery (n=23) or SA (n=61) underwent a GH-profile including an OGTT, at baseline and after 12 months...
October 9, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28992562/a-phase-ib-dose-escalation-study-of-the-safety-and-pharmacokinetics-of-pictilisib-in-combination-with-either-paclitaxel-and-carboplatin-with-or-without-bevacizumab-or-pemetrexed-and-cisplatin-with-or-without-bevacizumab-in-patients-with-advanced-non-small-cell
#13
Jean-Charles Soria, Alex A Adjei, Rastilav Bahleda, Benjamin Besse, Charles Ferte, David Planchard, Jing Zhou, Joseph Ware, Kari Morrissey, Geetha Shankar, Wei Lin, Jennifer L Schutzman, Grace K Dy, Harry J M Groen
AIM: The phosphatidylinositol 3-kinase (PI3K) pathway is a potential therapeutic target in non-small cell lung cancer (NSCLC). This study aimed to evaluate the pan-PI3K inhibitor pictilisib in combination with first-line treatment regimens that were the standard of care at the time of study, in patients with NSCLC. PATIENTS AND METHODS: A 3 + 3 dose-escalation study was performed using a starting daily dose of 60 mg pictilisib on days 1-14 of a 21-day cycle...
October 6, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28992206/dose-escalation-via-brachytherapy-boost-for-nasopharyngeal-carcinoma-in-the-era-of-intensity-modulated-radiation-therapy-and-combined-chemotherapy
#14
Hsing-Lung Chao, Shao-Cheng Liu, Chih-Cheng Tsao, Kuen-Tze Lin, Steve P Lee, Cheng-Hsiang Lo, Wen-Yen Huang, Ming-Yueh Liu, Yee-Min Jen, Chun-Shu Lin
To investigate if dose escalation using intracavitary brachytherapy (ICBT) improves local control for nasopharyngeal carcinoma (NPC) in the era of intensity-modulated radiation therapy (IMRT) and concurrent chemoradiation treatment (CCRT). We retrospectively analyzed 232 patients with Stage T1-3 N0-3 M0 NPC who underwent definitive IMRT with or without additional ICBT boost between 2002 and 2013. For most of the 124 patients who had ICBT boost, the additional brachytherapy was given as 6 Gy in 2 fractions completed within 1 week after IMRT of 70 Gy...
July 7, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28990119/dual-src-and-egfr-inhibition-in-combination-with-gemcitabine-in-advanced-pancreatic-cancer-phase-i-results-a-phase-i-clinical-trial
#15
Dana B Cardin, Laura W Goff, Emily Chan, Jennifer G Whisenant, G Dan Ayers, Naoko Takebe, Lori R Arlinghaus, Thomas E Yankeelov, Jordan Berlin, Nipun Merchant
Pancreatic adenocarcinoma remains a major therapeutic challenge, as the poor (<8%) 5-year survival rate has not improved over the last three decades. Our previous preclinical data showed cooperative attenuation of pancreatic tumor growth when dasatinib (Src inhibitor) was added to erlotinib (EGFR inhibitor) and gemcitabine. Thus, this study was designed to determine the maximum-tolerated dose of the triplet combination. Standard 3 + 3 dose escalation was used, starting with daily oral doses of 70 mg dasatinib and 100 mg erlotinib with gemcitabine on days 1, 8, and 15 (800 mg/m(2)) of a 28-day cycle (L0)...
October 9, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/28989000/use-of-18-f-fdg-pet-ct-imaging-to-determine-internal-mammary-lymph-node-location-for-radiation-therapy-treatment-planning-in-breast-cancer-patients
#16
Tima Davidson, Merav Ben-David, Shira Galper, Tess Haskin, Megan Howes, Roland Scaife, Nayroz Kanana, Uri Amit, Noam Weizman, Bar Chikman, Elinor Goshen, Simona Ben-Haim, Zvi Symon, Jeffrey Goldstein
PURPOSE: Adjuvant internal mammary lymph node (IMN) radiation is often delivered with 2-dimensional techniques that use anatomic landmarks and predetermined depths for field placement and dose specification. In contrast, 3-dimensional planning uses the internal mammary vessels (IMVs) to localize the IMNs for planning. Our purpose was to determine if localization of the involved IMN (i-IMN) by (18)F-labeled fluorodeoxyglucose positron emission tomography-computed tomography ((18)F-FDG PET-CT) offers opportunities to improve treatment...
November 5, 2016: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28988377/phase-i-study-of-sorafenib-and-tipifarnib-for-recurrent-glioblastoma-nabtc-05-02
#17
Phioanh Leia Nghiemphu, Victoria Asuquo Ebiana, Patrick Wen, Mark Gilbert, Lauren E Abrey, F Lieberman, Lisa M DeAngelis, H Ian Robins, W K Alfred Yung, Susan Chang, Jan Drappatz, Minesh P Mehta, Victor A Levin, Kenneth Aldape, Janet E Dancey, J J Wright, Michael Prados, John Kuhn, Timothy F Cloughesy
Recurrent glioblastoma (GBM) has a very low 6-month progression free survival (PFS) with currently available treatments. Combination chemotherapy to target multiple cell signaling pathways is currently being investigated in order to improve prognosis for recurrent disease. The purpose of this phase I study was to determine the maximum tolerated dose (MTD) for the combination of tipifarnib and sorafenib for the treatment of recurrent GBM. Patients with pathologically proven WHO grade IV GBM and radiographically proven tumor recurrence were eligible for this study...
October 7, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28987747/treating-locally-advanced-lung-cancer-with-a-1-5t-mr-linac-effects-of-the-magnetic-field-and-irradiation-geometry-on-conventionally-fractionated-and-isotoxic-dose-escalated-radiotherapy
#18
Hannah E Bainbridge, Martin J Menten, Martin F Fast, Simeon Nill, Uwe Oelfke, Fiona McDonald
PURPOSE: This study investigates the feasibility and potential benefits of radiotherapy with a 1.5T MR-Linac for locally advanced non-small cell lung cancer (LA NSCLC) patients. MATERIAL AND METHODS: Ten patients with LA NSCLC were retrospectively re-planned six times: three treatment plans were created according to a protocol for conventionally fractionated radiotherapy and three treatment plans following guidelines for isotoxic target dose escalation. In each case, two plans were designed for the MR-Linac, either with standard (∼7mm) or reduced (∼3mm) planning target volume (PTV) margins, while one conventional linac plan was created with standard margins...
October 4, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28986924/physician-s-appraisal-versus-documented-signs-and-symptoms-in-the-interpretation-of-food-challenge-tests-the-europrevall-birth-cohort
#19
Linus B Grabenhenrich, Andreas Reich, Doreen McBride, Aline Sprikkelman, Graham Roberts, Kate E C Grimshaw, Alessandro G Fiocchi, Photini Saxoni-Papageorgiou, Nikolaos G Papadopoulos, Ana Fiandor, Santiago Quirce, Marek L Kowalski, Sigurveig T Sigurdardottir, Ruta Dubakiene, Jonathan O B Hourihane, Leonard Rosenfeld, Bodo Niggemann, Thomas Keil, Kirsten Beyer
BACKGROUND: Blinded food challenges are considered the current gold standard for the diagnosis of food allergies. We used data from a pan-European multicentre project to assess differences between study centres, aiming to identify the impact of subjective aspects for the interpretation of oral food challenges. METHODS: Nine study centres of the EuroPrevall birth cohort study on food allergy recruited 12,049 newborns and followed them for up to 30 months in regular intervals...
October 6, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28984010/safety-and-dose-dependency-of-eptacog-beta-activated-in-a-dose-escalation-study-of-non-bleeding-congenital-haemophilia-a-or-b-patients-with-or-without-inhibitors
#20
J Ducore, J B Lawrence, M Simpson, L Boggio, A Bellon, J Burggraaf, J Stevens, M Moerland, J Frieling, J Reijers, M Wang
INTRODUCTION: Varying initial doses of activated eptacog beta (recombinant human FVIIa, rhFVIIa) may provide therapeutic options when treating bleeding in patients with congenital haemophilia who have developed inhibitory antibodies to factor VIII (FVIII) or factor IX (FIX). This study evaluated escalated doses of a new rhFVIIa product as a prelude to selecting the doses for clinical efficacy evaluation in haemophilia patients. AIM: To assess the safety, pharmacokinetics, and laboratory pharmacodynamics of 3 doses of rhFVIIa in non-bleeding patients with congenital haemophilia A or B with or without inhibitors...
October 5, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
keyword
keyword
42481
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"