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Co morbids with tuberculosis

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https://www.readbyqxmd.com/read/27921633/healthcare-resources-are-inadequate-to-address-the-burden-of-illness-among-hiv-infected-male-prisoners-in-malaysia
#1
Joseph Bick, Gabriel Culbert, Haider A Al-Darraji, Clayton Koh, Veena Pillai, Adeeba Kamarulzaman, Frederick Altice
Purpose Criminalization of drug use in Malaysia has concentrated people who inject drugs (PWID) and people living with HIV into prisons where health services are minimal and HIV-related mortality is high. Few studies have comprehensively assessed the complex health needs of this population. The paper aims to discuss these issues. Design/methodology/approach From October 2012 through March 2013, 221 sequentially selected HIV-infected male prisoners underwent a comprehensive health assessment that included a structured history, physical examination, and clinically indicated diagnostic studies...
December 19, 2016: International Journal of Prisoner Health
https://www.readbyqxmd.com/read/27917198/diabetes-mellitus-among-tuberculosis-patients-a-cross-sectional-study-from-pakistan
#2
Zarfishan Tahir, Mansur-Ud-Din Ahmad, Abdul Majeed Akhtar, Tahir Yaqub, Muhammad Hassan Mushtaq, Hasnain Javed
BACKGROUND: The co-occurrence of diabetes mellitus (DM) and tuberculosis (TB) is largely associated with high frequency of morbidity. OBJECTIVE: To determine the prevalence of DM among TB patients and describe the socio-demographic and behavioral factors associated with TB-DM co-occurrence. METHODS: We enrolled 500 TB patients from September, 2014 to August 2015 at four major public sector hospitals of Lahore, Pakistan. A questionnaire was used to collect information regarding associated socio-demographic and behavioral factors of the patients...
September 2016: African Health Sciences
https://www.readbyqxmd.com/read/27915106/insights-gained-from-ancient-biomolecules-into-past-and-present-tuberculosis-a-personal-perspective
#3
REVIEW
Helen D Donoghue
Ancient and historical tuberculosis (TB) can be recognized by its typical paleopathology in human remains. Using paleomicrobiology, it is possible to detect many more individuals infected with TB but with no visible lesions. Due to advances in molecular analysis over the past two decades, it is clear that TB was widespread in humans from the Neolithic period until the present day. Past human populations were associated with different lineages of the Mycobacterium tuberculosis (MTB) complex, thereby elucidating early human migrations...
November 30, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27891359/diabetes-mellitus-among-newly-diagnosed-tuberculosis-patients-in-tribal-odisha-an-exploratory-study
#4
Magna Manjareeka, Subrata Kumar Palo, Subhashisa Swain, Sandipana Pati, Sanghamitra Pati
INTRODUCTION: The association between Diabetes Mellitus (DM) and Tuberculosis (TB) poses a strong public health challenge. Tribal ethnics possess a different propensity towards infectious and haematological diseases which may influence the inter-relationship of DM and TB and thus merit separate attention. AIM: To investigate the prevalence of diabetes in newly diagnosed pulmonary TB patients of tribal ethnicity in Odisha. MATERIALS AND METHODS: A cross-sectional study was carried out over a period of 9 months at four designated TB microscopic centres in a tribal district (Malkangiri) of Odisha...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27889593/prevalence-and-patterns-of-cigarette-smoking-among-patients-co-infected-with-human-immunodeficiency-virus-and-tuberculosis-in-tanzania
#5
Ramadhani Stephano Mwiru, Tumaini Joseph Nagu, Pamela Kaduri, Ferdinand Mugusi, Wafaie Fawzi
INTRODUCTION: Cigarette smoking is one of the major risk factors for non-AIDS related morbidities and is highly prevalent among HIV infected people. However, no reports exist from Tanzania, one of the countries highly affected by the HIV pandemic and one of Africa's biggest tobacco producer. METHODS: We examined the patterns and prevalence of cigarette smoking among HIV and TB co-infected adult patients in Dar es Salaam using a cross sectional study design. Proportions were used to describe the pattern of cigarette smoking...
November 12, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27867891/bangladesh-national-guidelines-on-the-management-of-tuberculosis-and-diabetes-mellitus-co-morbidity-summary
#6
REVIEW
Mohammad Delwar Hossain, Jamal Uddin Ahmed, Muhammad Abdur Rahim, A K M Musa, Zafar Ahmed Latif
Tuberculosis (TB) and diabetes mellitus (DM) have synergetic relationship. People with diabetes are 2-3 times at higher risk of getting active TB disease. On the other hand, TB or anti-TB treatment may cause glucose intolerance. The dual disease of DM and TB is more likely to be associated with atypical disease presentation, higher probability of treatment failure and complications. In most of the health-care delivery systems of the world, DM and TB are managed separately by two vertical health-care delivery programs in spite of clear interaction between the two diseases...
November 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27865391/modulation-of-dendritic-cell-and-monocyte-subsets-in-tuberculosis-diabetes-co-morbidity-upon-standard-tuberculosis-treatment
#7
Nathella Pavan Kumar, Kadar Moideen, Shanmugam Sivakumar, Pradeep A Menon, Vijay Viswanathan, Hardy Kornfeld, Subash Babu
Type 2 diabetes mellitus (DM) is a major risk factor for the development of active pulmonary tuberculosis (PTB), with development of DM pandemic in countries where tuberculosis (TB) is also endemic. However, the effect of anti-TB treatment on the changes in dentritic cell (DC) and monocyte subset phenotype in TB-DM co-morbidity is not well understood. In this study, we characterized the frequency of DC and monocyte subsets in individuals with PTB with (PTB-DM) or without coincident diabetes mellitus (PTB-NDM) before, during and after completion of anti-TB treatment...
December 2016: Tuberculosis
https://www.readbyqxmd.com/read/27856197/characterization-of-2-hydroxy-1-naphthaldehyde-isonicotinoyl-hydrazone-as-a-novel-inhibitor-of-methionine-aminopeptidases-from-mycobacterium-tuberculosis
#8
Sarah F John, Emmanuel Aniemeke, Ngan P Ha, Curtis R Chong, Peihua Gu, Jiangbing Zhou, Ying Zhang, Edward A Graviss, Jun O Liu, Omonike A Olaleye
Mycobacterium tuberculosis (Mtb) and the Human Immunodeficiency Virus (HIV) pose a major public health threat. The 2015 World Health Organization (WHO) report estimates that one in three HIV deaths is due to Mtb, the causative agent of Tuberculosis (TB). The lethal synergy between these two pathogens leads to a decline in the immune function of infected individuals as well as a rise in morbidity and mortality rates. The deadly interaction between TB and HIV, along with the heightened emergence of drug resistance, drug-drug interactions, reduced drug efficacy and increased drug toxicity, has made the therapeutic management of co-infected individuals a major challenge...
September 28, 2016: Tuberculosis
https://www.readbyqxmd.com/read/27846812/predictors-of-hospitalization-of-tuberculosis-patients-in-montreal-canada-a-retrospective-cohort-study
#9
Lisa A Ronald, J Mark FitzGerald, Andrea Benedetti, Jean-François Boivin, Kevin Schwartzman, Gillian Bartlett-Esquilant, Dick Menzies
BACKGROUND: Hospitalization is the most costly health system component of tuberculosis (TB) control programs. Our objectives were to identify how frequently patients are hospitalized, and the factors associated with hospitalizations and length-of-stay (LOS) of TB patients in a large Canadian city. METHODS: We extracted data from the Montreal TB Resource database, a retrospective cohort of all active TB cases reported to the Montreal Public Health Department between January 1996 and May 2007...
November 15, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27801499/six-month-therapy-for-abdominal-tuberculosis
#10
REVIEW
Sophie Jullien, Siddharth Jain, Hannah Ryan, Vineet Ahuja
BACKGROUND: Tuberculosis (TB) of the gastrointestinal tract and any other organ within the abdominal cavity is abdominal TB, and most guidelines recommend the same six-month regimen used for pulmonary TB for people with this diagnosis. However, some physicians are concerned whether a six-month treatment regimen is long enough to prevent relapse of the disease, particularly in people with gastrointestinal TB, which may sometimes cause antituberculous drugs to be poorly absorbed. On the other hand, longer regimens are associated with poor adherence, which could increase relapse, contribute to drug resistance developing, and increase costs to patients and health providers...
November 1, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27798659/double-trouble-prevalence-and-factors-associated-with-tuberculosis-and-diabetes-comorbidity-in-bangladesh
#11
Malabika Sarker, Mrittika Barua, Fiona Guerra, Avijit Saha, Afzal Aftab, A H M Mahbub Latif, Shayla Islam, Akramul Islam
BACKGROUND: Diabetes among tuberculosis patients increases the risk of tuberculosis treatment failure, death, and development of multidrug-resistant tuberculosis. Yet, there is no data is available in Bangladesh on the prevalence of diabetes among tuberculosis patients. The objective of the current study was to estimate prevalence and identify factors associated with tuberculosis-diabetes co-morbidity among TB patients enrolled in the Directly Observed Treatment, Short course program...
2016: PloS One
https://www.readbyqxmd.com/read/27790502/rifampicin-induced-concomitant-renal-injury-and-hepatitis
#12
Bharti Chogtu, Vyshak Uddur Surendra, Rahul Magazine, Preetam Rajgopal Acharya, Devesh Bhaskar Yerrapragada
Adverse drug reactions are not unusual during Anti-Tubercular Therapy (ATT). One of the common complications of anti-tubercular treatment is drug induced hepatitis and renal insufficiency has also been reported. Renal failure and/or hepatitis encountered during treatment of tuberculosis can have varied aetiologies: drug induced, concomitant viral infection, pre-existing co-morbidities or a combination of these. Since, hepatitis and/or renal insufficiency can be life threatening a prompt diagnosis is warranted, where drugs should be kept as one of the important cause...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27790320/surgical-management-in-elderly-patients-with-tuberculous-spondylodiscitis-ten-year-mortality-audit-study
#13
Manish Kundanmal Kothari, Kunal Chandrakant Shah, Agnivesh Tikoo, Abhay Madhusudan Nene
STUDY DESIGN: Retrospective study. PURPOSE: To evaluate the factors affecting immediate postoperative mortality in elderly patients with tuberculous spondylodiscitis. OVERVIEW OF LITERATURE: Treatment of spinal tuberculosis in the elderly involves consideration of age and co-morbidities, and often leads to an extended conservative management. Surgical intervention in these patients becomes a complex decision. There are no studies on risk factors of mortality in surgically treated elderly with tuberculous spondylodiscitis...
October 2016: Asian Spine Journal
https://www.readbyqxmd.com/read/27751168/antiretroviral-therapy-improves-survival-among-tb-hiv-co-infected-patients-who-have-cd4-t-cell-count-above-350cells-mm-3
#14
Simon Mutembo, Jane N Mutanga, Kebby Musokotwane, Lutangu Alisheke, Christopher C Whalen
BACKGROUND: Co-infection with Mycobacterium tuberculosis remains a leading cause of morbidity and mortality among HIV infected individuals especially in developing countries. Early initiation of cART in these patients when CD4+ T cell count is less than 200cells/mm(3) has reduced disease progression and mortality. However for patients with higher CD4+ T cell counts greater than 350cells/mm(3) evidence is conflicting. In this study we seek to evaluate the effectiveness of cART in reducing mortality among TB-HIV co-infected patients with CD4 + T cells above 350cells/mm(3) at the time of TB diagnosis...
October 17, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27732606/a-data-driven-evaluation-of-the-stop-tb-global-partnership-strategy-of-targeting-key-populations-at-greater-risk-for-tuberculosis
#15
Zoë M McLaren, Kathryn Schnippel, Alana Sharp
OBJECTIVE: Identifying those infected with tuberculosis (TB) is an important component of any strategy for reducing TB transmission and population prevalence. The Stop TB Global Partnership recently launched an initiative with a focus on key populations at greater risk for TB infection or poor clinical outcomes, due to housing and working conditions, incarceration, low household income, malnutrition, co-morbidities, exposure to tobacco and silica dust, or barriers to accessing medical care...
2016: PloS One
https://www.readbyqxmd.com/read/27717783/tuberculosis-diabetes-co-morbidity-is-characterized-by-heightened-systemic-levels-of-circulating-angiogenic-factors
#16
Nathella Pavan Kumar, Kadar Moideen, Shanmugam Sivakumar, Pradeep A Menon, Vijay Viswanathan, Hardy Kornfeld, Subash Babu
BACKGROUND: Tuberculosis-diabetes co-morbidity (TB-DM) is characterized by increased inflammation with elevated circulating levels of inflammatory cytokines and other factors. Circulating angiogenic factors are intricately involved in the angiogenesis-inflammation nexus. METHODS: To study the association of angiogenic factors with TB-DM, we examined the systemic levels of VEGF-A, VEGF-C, VEGF-D, VEGF-R1, VEGF-R2, VEGF-R3 in individuals with either TB-DM (n = 44) or TB alone (n = 44)...
October 4, 2016: Journal of Infection
https://www.readbyqxmd.com/read/27670679/tuberculous-spondylitis-diagnosed-through-xpert-mtb-rif-assay-in-urine-a-case-report
#17
George Sikalengo, Adria Ramirez, Diana Faini, Kim Mwamelo, Manuel Battegay, Levan Jugheli, Christoph Hatz, Klaus Reither, Emilio Letang
BACKGROUND: Extrapulmonary tuberculosis (EPTB) is associated with high rates of morbidity and mortality. Diagnosis of EPTB is challenging in resource-limited settings due to difficulties in obtaining samples, as well as the paucibacillarity of the specimens. Skeletal tuberculosis accounts for 10-35 % of EPTB cases, with vertebral osteomyelitis (Pott's disease) representing 50 % of the cases. We present two cases of suspected Pott's disease, diagnosed through GeneXpert MTB/RIF assay in urine at a rural Tanzanian hospital...
September 26, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27637104/persistent-infectious-and-tropical-diseases-in-immigrant-correctional-populations
#18
L Getaz, L Da Silva-Santos, H Wolff, M Vitoria, N Serre-Delcor, J C Lozano-Becerra, F Chappuis, P Albajar-Viñas
A number of infectious diseases amongst travelers and the immigrant populations are a major public health concern. Some have a long incubation period or remain asymptomatic or paucisymptomatic for many years before leading to significant clinical manifestations and/or complications. HIV, hepatitis B and C, tuberculosis or latent syphilis are among the most significant persistent diseases in migrants. Schistosomiasis and strongyloidiasis, for instance, are persistent helminthic infections that may cause significant morbidity, particularly in patients co-infected with HIV, hepatitis B and C...
October 2016: Revista Española de Sanidad Penitenciaria
https://www.readbyqxmd.com/read/27624908/occult-hepatitis-b-virus-infection-clinical-implications-in-tuberculosis-treatment
#19
C Trigo, P E A A do Brasil, M J M Costa, L de Castro
Occult hepatitis B virus infection (OBI) is characterized by the absence of HBsAg and persistence of the virus genome (HBV-DNA) in liver tissue and/or blood. OBI has been reported in several clinical contexts. However, the clinical significance of OBI in tuberculosis (TB) treatment is unknown. We investigated the OBI prevalence and its impact on the risk of drug-induced liver injury (DILI) during TB treatment. This was a prospective cohort study with one hundred patients who were treated for TB from 2008 to 2015...
September 13, 2016: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/27577087/modulation-of-the-immune-response-to-mycobacterium-tuberculosis-during-malaria-m-tuberculosis-co-infection
#20
R C Chukwuanukwu, C C Onyenekwe, L Martinez-Pomares, R Flynn, S Singh, G I Amilo, N R Agbakoba, J O Okoye
Tuberculosis (TB) causes significant morbidity and mortality on a global scale. The African region has 24% of the world's TB cases. TB overlaps with other infectious diseases such as malaria and HIV, which are also highly prevalent in the African region. TB is a leading cause of death among HIV-positive patients and co-infection with HIV and TB has been described as a syndemic. In view of the overlapping epidemiology of these diseases, it is important to understand the dynamics of the immune response to TB in the context of co-infection...
August 31, 2016: Clinical and Experimental Immunology
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