Xianan Zhang, Jing Wang, Yuansheng Liu, Hemin Wang, Bin Li, Qing Li, Yi Wang, Yuru Zong, Jiajia Wang, Qingtao Meng, Shenshen Wu, Rongzhang Hao, Xiaobo Li, Rui Chen, Hanqing Chen
Despite increasing concerns regarding the harmful effects of plastic-induced gut injury, mechanisms underlying the initiation of plastic-derived intestinal toxicity remain unelucidated. Here, mice were subjected to long-term exposure to polystyrene nanoplastics (PS-NPs) of varying sizes (80, 200, and 1000 nm) at doses relevant to human dietary exposure. PS-NPs exposure did not induce a significant inflammatory response, histopathological damage, or intestinal epithelial dysfunction in mice at a dosage of 0...
April 2, 2024: Science of the Total Environment